Inside cells, DNA is coiled around histone proteins, making spools of nucleosomes. Cynthia Wolberger studies the molecular machines that unwrap the chromatin packing to transcribe or repair genes.
The structures reveal complicated biological mechanisms that involve an alphabet soup of chemical bonds, epigenetic tags, amino acid positions, several proteins, and multiple protein domains.
A recent study investigated the way in which a protein called ubiquitin that is attached to a histone helps an enzyme that attaches another type of chemical tag to the histone core of a nucleosome. For those new to the field, Wolberger suggests …Find out More »