Three weeks after most research on campus was paused in the first wave of the U.S. coronavirus pandemic, Yuh Min Chook learned that a cancer drug her group helped develop was going into a small global randomized clinical trial for hospitalized patients with COVID-19.
The drug works deep inside cells, blocking transport from the nucleus to the cytoplasm. As a cancer treatment, it seems to work by blocking the exit of native cancer-fighting molecules. Locked in the nucleus, the trapped proteins and RNA can counteract many oncogenic pathways that suppress tumors, growth, and inflammation.
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