In structural biology. there are few more onerous tasks than coaxing reluctant proteins into crystals. “Unfortunately, that is really a huge bottleneck,” says Sarah E.J. Bowman, who heads the National High-Throughput Crystallization (HTX) Center in upstate New York. The center aims to increase the odds of success for this essential step in much of structural biology.
Sooner or later, by old-fashioned trial and error, many researchers find the magic recipe to crystallize their protein at their own lab benches. After all, nearly 90% of structures deposited in the Protein Data Bank (PDB) started as crystals of …Find out More »