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  • The mobile element that conveys methicillin resistance to staph includes a gene that encodes for Cch. Learn more about Phoebe Rice's Chicago lab.

  • AlkD (grey) crystal structure bound to DNA containing 3-deaza-3-methyldeoxyadenosine (light green), from Brandt Eichman. Read the full story.

  • Jalview Developer Geoff Barton's desk with the JalviewAbacus (right) and displayed a dendrogram (tree) for the set of sequences shown in the alignment, using Jalview linked to Chimera. Read the full story here.

  • Project MAC display system, circa 1965,

    The Project MAC display system, circa 1965. Read more about the history of molecular graphics software and UCSF Chimera in our SBGrid Tale featuring Bob Langridge and Tom Ferrin.

  • You'll find SBGrid in ~350 structural biology labs located at over 100 different institutions in about 20 countries around the world. See full map and read more in eLIFE.

  • Daniel Panne's group, which relocated in 2018 to the University of Leicester, looks at the language of gene regulation and visualizes the catalytic core of p300. Read the full story.

  • Professor Catherine Drennan of MIT

    The SBGrid Consortium provides structural biologists worldwide with access to the software they need to discover the shapes of the molecules of life. Read more in eLIFE.

  • The AdipoR2 structure revealing the presence of a bound fatty acid at a zinc binding site, from Sebastien Granier's lab at the French National Institute of Health and Medical Research (INSERM), Institut de Génomique Fonctionnelle, Montpellier France. Read more.

  • Tom Rapoport's group at Harvard Medical School captured the crystal structure of the active translocon being pushed through the hourglass-shaped SecY protein-conducting channel. You can find out more about the science and learn some personal history in our Member Tale.

  • The first high-resolution (2.8 Å) X-ray crystal structure of the transcription initiation complex of Mycobacterium smegmatis, from the laboratory of Seth Darst at Rockefeller University.

    Image courtesy of E. Campbell.

  • In traditional X-ray crystallography, X-rays bombard 1 crystal 100s of times. This syringe, developed for a dynamic temperature experiment in James Fraser's lab at UCSF, shoots 1,000s of crystals into an X-ray-free electron laser beam, one at a time. Learn more.

    Image courtesy of Alexander Wolff.

Recent Software Updates

Oct 04 | topaz-filament

A pipeline for particle detection in cryo-electron microscopy images using convolutional neural networks trained from positive and unlabele… >>
Oct 04 | ModelAngelo

ModelAngelo is an automatic atomic model building program for cryo-EM maps. >>
Sep 29 | Scipion

an image processing framework to obtain 3D models of macromolecular complexes using 3D EM that allows you to execute workflows combining di… >>
Sep 29 | RELION

(REgularised LIkelihood OptimisatioN) a stand-alone computer program for Maximum A Posteriori (MAP) refinement of (multiple) 3D reconstruct… >>
Sep 27 | AlphaFold

an implementation of the inference pipeline of AlphaFold v2.0 using a completely new model that was entered in CASP14. >>
Sep 25 | ProteinMPNN

is a deep learning based protein sequence design method. >>
Sep 23 | BCFtools

a set of utilities that manipulate variant calls in the Variant Call Format (VCF) and its binary counterpart BCF. All commands work transpa… >>
Thanks to the National Science Foundation

With Partial Support from the National Science Foundation Research Coordination Network MCB #0639193 and NSF EAGER #1448069. Please cite SBGrid's eLife paper and follow our publication guidelines.

Latest news

SBGrid/Harvard Shield

SBGrid Webinar Series

Join us for our Software Webinar Series - Tuesdays at 12pm ET - hear from software developers about what's new in structural biology. Community members can connect via Zoom and …

Structure of Equity

Structure of Equity

Numbers speak clearly to Jamaine Davis. As a boy growing up on Long Island, math came so easy to him that one of his family nicknames was "the professor." Other …

Life and Death of a Cell

Life and Death of a Cell

About age 16, pondering his future, Evripidis (Evris) Gavathiotis decided he wanted to work as a chemist in drug discovery. It was personal. Growing up in Greece, he had witnessed …

Swimming with atoms

Swimming with atoms

Deb Kelly gets a lot of scientific mileage out of her dog Annie. Most mornings, they take long runs together in the rolling countryside near her Pennsylvania State University laboratory. …

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