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52 Member Publications for May

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Structure and evolution of the 4-helix bundle domain of Zuotin, a J-domain protein co-chaperone of Hsp70.
1. PLoS One - published May 16, 2019
2. Shrestha OK, Sharma R, Tomiczek B, Lee W, Tonelli M, Cornilescu G, Stolarska M, Nierzwicki L, Czub J, Markley JL, Marszalek J, Ciesielski SJ, Craig EA
DNA-guided DNA cleavage at moderate temperatures by Clostridium butyricum Argonaute.
1. Nucleic Acids Res - published May 9, 2019
2. Hegge JW, Swarts DC, Chandradoss SD, Cui TJ, Kneppers J, Jinek M, Joo C, van der Oost J
Effects of α-tubulin acetylation on microtubule structure and stability.
1. Proc Natl Acad Sci U S A - published May 9, 2019
2. Eshun-Wilson L, Zhang R, Portran D, Nachury MV, Toso DB, Löhr T, Vendruscolo M, Bonomi M, Fraser JS, Nogales E
Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach.
1. J Biomol NMR - published May 9, 2019
2. Kaur H, Hartmann JB, Jakob RP, Zahn M, Zimmermann I, Maier T, Seeger MA, Hiller S
INDRA-IPM: interactive pathway modeling using natural language with automated assembly.
1. Bioinformatics - published May 9, 2019
2. Todorov PV, Gyori BM, Bachman JA, Sorger PK
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs.
1. Nat Commun - published May 9, 2019
2. Kundert K, Lucas JE, Watters KE, Fellmann C, Ng AH, Heineike BM, Fitzsimmons CM, Oakes BL, Qu J, Prasad N, Rosenberg OS, Savage DF, El-Samad H, Doudna JA, Kortemme T
How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates.
1. Autophagy - published May 8, 2019
2. Turco E, Witt M, Abert C, Bock-Bierbaum T, Su MY, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, Gamper A, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens S
Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway.
1. Trends Biochem Sci - published May 8, 2019
2. Mullins EA, Rodriguez AA, Bradley NP, Eichman BF
Phosphorylation of Tyr950 in the proteasome scaffolding protein RPN2 modulates its interaction with theubiquitin receptor RPN13.
1. J Biol Chem - published May 7, 2019
2. Hemmis CW, Heard SC, Hill CP
Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor.
1. Cell - published May 6, 2019
2. Basore K, Kim AS, Nelson CA, Zhang R, Smith BK, Uranga C, Vang L, Cheng M, Gross ML, Smith J, Diamond MS, Fremont DH
Chemical disarming of isoniazid resistance in <i>Mycobacterium tuberculosis</i>.
1. Proc Natl Acad Sci U S A - published May 6, 2019
2. Flentie K, Harrison GA, Tükenmez H, Livny J, Good JAD, Sarkar S, Zhu DX, Kinsella RL, Weiss LA, Solomon SD, Schene ME, Hansen MR, Cairns AG, Kulén M, Wixe T, Lindgren AEG, Chorell E, Bengtsson C, Krishnan KS, Hultgren SJ, Larsson C, Almqvist F, Stallings CL
Characterization of rare NEIL1 variants found in East Asian populations.
1. DNA Repair (Amst) - published May 3, 2019
2. Minko IG, Vartanian VL, Tozaki NN, Linde OK, Jaruga P, Coskun SH, Coskun E, Qu C, He H, Xu C, Chen T, Song Q, Jiao Y, Stone MP, Egli M, Dizdaroglu M, McCullough AK, Lloyd RS
eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.
1. Science - published May 3, 2019
2. Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A
Q-FADD: A Mechanistic Approach for Modeling the Accumulation of Proteins at Sites of DNA Damage.
1. Biophys J - published May 3, 2019
2. Mahadevan J, Rudolph J, Jha A, Tay JW, Dragavon J, Grumstrup EM, Luger K
Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3.
1. Nat Commun - published May 2, 2019
2. Schneider T, Hung LH, Aziz M, Wilmen A, Thaum S, Wagner J, Janowski R, Müller S, Schreiner S, Friedhoff P, Hüttelmaier S, Niessing D, Sattler M, Schlundt A, Bindereif A
Targeting mitochondrial structure sensitizes acute myeloid leukemia to Venetoclax treatment.
1. Cancer Discov - published May 2, 2019
2. Chen X, Glytsou C, Zhou H, Narang S, Reyna DE, Lopez A, Sakellaropoulos T, Gong Y, Kloetgen A, Yap YS, Wang E, Gavathiotis E, Tsirigos A, Tibes R, Aifantis I
Computational prediction and in vitro validation of VEGFR1 as a novel protein target for 2,3,7,8-tetrachlorodibenzo-p-dioxin.
1. Sci Rep - published May 2, 2019
2. Chitrala KN, Yang X, Busbee B, Singh NP, Bonati L, Xing Y, Nagarkatti P, Nagarkatti M
Late steps in bacterial translation initiation visualized using time-resolved cryo-EM.
1. Nature - published May 2, 2019
2. Kaledhonkar S, Fu Z, Caban K, Li W, Chen B, Sun M, Gonzalez RL Jr, Frank J
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
1. Nat Struct Mol Biol - published May 2, 2019
2. Yan C, Dodd T, He Y, Tainer JA, Tsutakawa SE, Ivanov I
Proteomic insight into the pathogenesis of CAPN5-vitreoretinopathy.
1. Sci Rep - published May 2, 2019
2. Velez G, Yang J, Li AS, Tsang SH, Bassuk AG, Mahajan VB
Author Correction: Tissue clearing of both hard and soft tissue organs with the PEGASOS method.
1. Cell Res - published May 2, 2019
2. Jing D, Zhang S, Luo W, Gao X, Men Y, Ma C, Liu X, Yi Y, Bugde A, Zhou BO, Zhao Z, Yuan Q, Feng JQ, Gao L, Ge WP, Zhao H
DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro.
1. Nucleic Acids Res - published May 2, 2019
2. Bian K, Lenz SAP, Tang Q, Chen F, Qi R, Jost M, Drennan CL, Essigmann JM, Wetmore SD, Li D
Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex.
1. Nucleic Acids Res - published May 2, 2019
2. Paul Solomon Devakumar LJ, Gaubitz C, Lundblad V, Kelch BA, Kubota T
The extracellular gate shapes the energy profile of an ABC exporter.
1. Nat Commun - published May 2, 2019
2. Hutter CAJ, Timachi MH, Hürlimann LM, Zimmermann I, Egloff P, Göddeke H, Kucher S, Štefanić S, Karttunen M, Schäfer LV, Bordignon E, Seeger MA
Emerging RNA-binding roles in the TRIM family of ubiquitin ligases.
1. Biol Chem - published May 2, 2019
2. Williams FP, Haubrich K, Perez-Borrajero C, Hennig J
The CXXC Motifs Are Essential for the Function of BosR in <i>Borrelia burgdorferi</i>.
1. Front Cell Infect Microbiol - published May 2, 2019
2. Mason C, Liu X, Prabhudeva S, Ouyang Z
ARF GTPases and their GEFs and GAPs: concepts and challenges.
1. Mol Biol Cell - published May 1, 2019
2. Sztul E, Chen PW, Casanova JE, Cherfils J, Dacks JB, Lambright DG, Lee FS, Randazzo PA, Santy LC, Schürmann A, Wilhelmi I, Yohe ME, Kahn RA
Clinical effect of postoperative chemoradiotherapy in resected advanced laryngeal squamous cell carcinoma.
1. Oncol Lett - published May 1, 2019
2. Zhang M, Deng W, Gong H, Li C, Wang Y, Liu X, Tao L, Zhou L
The cryo-EM method microcrystal electron diffraction (MicroED).
1. Nat Methods - published May 1, 2019
2. Nannenga BL, Gonen T
Go go gadget glycoprotein!: HSV-1 draws on its sizeable glycoprotein tool kit to customize its diverse entry routes.
1. PLoS Pathog - published May 1, 2019
2. Hilterbrand AT, Heldwein EE
Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.
1. Science - published May 1, 2019
2. Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK
Different genetic and morphological outcomes for phages targeted by single or multiple CRISPR-Cas spacers.
1. Philos Trans R Soc Lond B Biol Sci - published May 1, 2019
2. Watson BNJ, Easingwood RA, Tong B, Wolf M, Salmond GPC, Staals RHJ, Bostina M, Fineran PC
Switch-like activation of Bruton's tyrosine kinase by membrane-mediated dimerization.
1. Proc Natl Acad Sci U S A - published May 1, 2019
2. Chung JK, Nocka LM, Decker A, Wang Q, Kadlecek TA, Weiss A, Kuriyan J, Groves JT
Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.
1. Proc Natl Acad Sci U S A - published May 1, 2019
2. Ashraf U, Tengo L, Le Corre L, Fournier G, Busca P, McCarthy AA, Rameix-Welti MA, Gravier-Pelletier C, Ruigrok RWH, Jacob Y, Vidalain PO, Pietrancosta N, Crépin T, Naffakh N
Backbone resonance assignments and secondary structure of Ebola nucleoprotein 600-739 construct.
1. Biomol NMR Assign - published May 1, 2019
2. Lee W, Tonelli M, Wu C, Aceti DJ, Amarasinghe GK, Markley JL
Regulation of cyclic oligoadenylate synthesis by the S. epidermidis Cas10-Csm complex.
1. RNA - published May 1, 2019
2. Nasef M, Muffly MC, Beckman AB, Rowe SJ, Walker FC, Hatoum-Aslan A, Dunkle JA
Structures suggest a mechanism for energy coupling by a family of organic anion transporters.
1. PLoS Biol - published May 1, 2019
2. Leano JB, Batarni S, Eriksen J, Juge N, Pak JE, Kimura-Someya T, Robles-Colmenares Y, Moriyama Y, Stroud RM, Edwards RH
Structure and assembly of pilotin-dependent and -independent secretins of the type II secretion system.
1. PLoS Pathog - published May 1, 2019
2. Howard SP, Estrozi LF, Bertrand Q, Contreras-Martel C, Strozen T, Job V, Martins A, Fenel D, Schoehn G, Dessen A
Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse.
1. Elife - published May 1, 2019
2. Zhang J, Li L, Huang H, Fang F, Webber HC, Zhuang P, Liu L, Dalal R, Tang PH, Mahajan VB, Sun Y, Li S, Zhang M, Goldberg JL, Hu Y
Receptor subtype discrimination using extensive shape complementary designed interfaces.
1. Nat Struct Mol Biol - published May 1, 2019
2. Dang LT, Miao Y, Ha A, Yuki K, Park K, Janda CY, Jude KM, Mohan K, Ha N, Vallon M, Yuan J, Vilches-Moure JG, Kuo CJ, Garcia KC, Baker D
Selective kinase inhibition shows that Bur1 (Cdk9) phosphorylates the Rpb1 linker in vivo.
1. Mol Cell Biol - published May 1, 2019
2. Chun Y, Joo YJ, Suh H, Batot G, Hill CP, Formosa T, Buratowski S
Solving the structure of Lgl2, a difficult blind test of unsupervised structure determination.
1. Proc Natl Acad Sci U S A - published May 1, 2019
2. Ufimtsev IS, Almagor L, Weis WI, Levitt M
Structural insights into the aPKC regulatory switch mechanism of the human cell polarity protein lethal giant larvae 2.
1. Proc Natl Acad Sci U S A - published May 1, 2019
2. Almagor L, Ufimtsev IS, Ayer A, Li J, Weis WI
Structure and functional reselection of the Mango-III fluorogenic RNA aptamer.
1. Nat Chem Biol - published May 1, 2019
2. Trachman RJ 3rd, Autour A, Jeng SCY, Abdolahzadeh A, Andreoni A, Cojocaru R, Garipov R, Dolgosheina EV, Knutson JR, Ryckelynck M, Unrau PJ, Ferré-D'Amaré AR
Highlight: young research groups in Germany.
1. Biol Chem - published May 1, 2019
2. GBM Young Investigators,., Hennig J, Feige MJ
Single and dual targeting of mutant EGFR with an allosteric inhibitor.
1. Cancer Discov - published May 1, 2019
2. To C, Jang J, Chen T, Park E, Mushajiang M, De Clercq DJH, Xu M, Wang S, Cameron MD, Heppner DE, Shin BH, Gero TW, Yang A, Dahlberg SE, Wong KK, Eck MJ, Gray NS, Janne PA
Self-tolerance curtails the B cell repertoire to microbial epitopes.
1. JCI Insight - published May 1, 2019
2. Watanabe A, Su KY, Kuraoka M, Yang G, Reynolds AE, Schmidt AG, Harrison SC, Haynes BF, St Clair EW, Kelsoe G
Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism.
1. Cell - published May 1, 2019
2. Watanabe A, McCarthy KR, Kuraoka M, Schmidt AG, Adachi Y, Onodera T, Tonouchi K, Caradonna TM, Bajic G, Song S, McGee CE, Sempowski GD, Feng F, Urick P, Kepler TB, Takahashi Y, Harrison SC, Kelsoe G
Selective inhibitors of FKBP51 employ conformational selection of dynamic invisible states.
1. Angew Chem Int Ed Engl - published May 1, 2019
2. Kumar Ankush Jagtap P, Asami S, Sippel C, Kaila V, Hausch F, Sattler M
Long-wavelength native-SAD phasing: opportunities and challenges.
1. IUCrJ - published May 1, 2019
2. Basu S, Olieric V, Leonarski F, Matsugaki N, Kawano Y, Takashi T, Huang CY, Yamada Y, Vera L, Olieric N, Basquin J, Wojdyla JA, Bunk O, Diederichs K, Yamamoto M, Wang M
Blood-Stage Malaria Parasite Antigens: Structure, Function, and Vaccine Potential.
1. J Mol Biol - published May 1, 2019
2. Salina ND, Tang WK, Tolia NH
Extensive loss of cell-cycle and DNA repair genes in an ancient lineage of bipolar budding yeasts.
1. PLoS Biol - published May 1, 2019
2. Steenwyk JL, Opulente DA, Kominek J, Shen XX, Zhou X, Labella AL, Bradley NP, Eichman BF, Čadež N, Libkind D, DeVirgilio J, Hulfachor AB, Kurtzman CP, Hittinger CT, Rokas A