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98 Member Publications for June

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Automatic Bayesian Weighting for SAXS Data.
1. Front Mol Biosci - published June 21, 2021
2. Spill YG, Karami Y, Maisonneuve P, Wolff N, Nilges M
Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses.
1. Front Immunol - published June 17, 2021
2. Chuang GY, Shen CH, Cheung CS, Gorman J, Creanga A, Joyce MG, Leung K, Rawi R, Wang L, Yang ES, Yang Y, Zhang B, Zhang Y, Kanekiyo M, Zhou T, DeKosky BJ, Graham BS, Mascola JR, Kwong PD
Editorial: Mechanisms of Fluorescent Proteins.
1. Front Mol Biosci - published June 14, 2021
2. Fang C, Drobizhev M, Ng HL, Pantazis P
Activity-based, bioorthogonal imaging of phospholipase D reveals spatiotemporal dynamics of GPCR-Gq signaling.
1. Cell Chem Biol - published June 9, 2021
2. Liang D, Cheloha RW, Watanabe T, Gardella TJ, Baskin JM
Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine.
1. Nat Commun - published June 9, 2021
2. Prattes M, Grishkovskaya I, Hodirnau VV, Rössler I, Klein I, Hetzmannseder C, Zisser G, Gruber CC, Gruber K, Haselbach D, Bergler H
Inherited nuclear pore substructures template post-mitotic pore assembly.
1. Dev Cell - published June 9, 2021
2. Chou YY, Upadhyayula S, Houser J, He K, Skillern W, Scanavachi G, Dang S, Sanyal A, Ohashi KG, Di Caprio G, Kreutzberger AJB, Vadakkan TJ, Kirchhausen T
A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression.
1. Sci Transl Med - published June 9, 2021
2. Nagele P, Palanca BJ, Gott B, Brown F, Barnes L, Nguyen T, Xiong W, Salloum NC, Espejo GD, Lessov-Schlaggar CN, Jain N, Cheng WWL, Komen H, Yee B, Bolzenius JD, Janski A, Gibbons R, Zorumski CF, Conway CR
Loss of the Bacterial Flagellar Motor Switch Complex upon Cell Lysis.
1. mBio - published June 8, 2021
2. Kaplan M, Tocheva EI, Briegel A, Dobro MJ, Chang YW, Subramanian P, McDowall AW, Beeby M, Jensen GJ
Handling heme with care.
1. Nat Chem Biol - published June 8, 2021
2. Brown BL, Iverson TM
Generation of ordered protein assemblies using rigid three-body fusion.
1. Proc Natl Acad Sci U S A - published June 8, 2021
2. Vulovic I, Yao Q, Park YJ, Courbet A, Norris A, Busch F, Sahasrabuddhe A, Merten H, Sahtoe DD, Ueda G, Fallas JA, Weaver SJ, Hsia Y, Langan RA, Plückthun A, Wysocki VH, Veesler D, Jensen GJ, Baker D
Interaction hot spots for phase separation revealed by NMR studies of a CAPRIN1 condensed phase.
1. Proc Natl Acad Sci U S A - published June 8, 2021
2. Kim TH, Payliss BJ, Nosella ML, Lee ITW, Toyama Y, Forman-Kay JD, Kay LE
Differential immune imprinting by influenza virus vaccination and infection in nonhuman primates.
1. Proc Natl Acad Sci U S A - published June 8, 2021
2. McCarthy KR, Von Holle TA, Sutherland LL, Oguin TH 3rd, Sempowski GD, Harrison SC, Moody MA
An interdomain hydrogen bond in the Rag GTPases maintains stable mTORC1 signaling in sensing amino acids.
1. J Biol Chem - published June 8, 2021
2. Egri SB, Shen K
An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial membrane.
1. EMBO J - published June 8, 2021
2. Lv F, Qi F, Zhang Z, Wen M, Kale J, Piai A, Du L, Wang S, Zhou L, Yang Y, Wu B, Liu Z, Del Rosario J, Pogmore J, Chou JJ, Andrews DW, Lin J, OuYang B
Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants.
1. Nature - published June 7, 2021
2. Xu J, Xu K, Jung S, Conte A, Lieberman J, Muecksch F, Lorenzi JCC, Park S, Schmidt F, Wang Z, Huang Y, Luo Y, Nair M, Wang P, Schulz JE, Tessarollo L, Bylund T, Chuang GY, Olia AS, Stephens T, Teng IT, Tsybovsky Y, Zhou T, Munster V, Ho DD, Hatziioannou T, Bieniasz PD, Nussenzweig MC, Kwong PD, Casellas R
Synthesis-temperature-regulated multi-enzyme-mimicking activities of ceria nanozymes.
1. J Mater Chem B - published June 7, 2021
2. Liu X, Wu J, Liu Q, Lin A, Li S, Zhang Y, Wang Q, Li T, An X, Zhou Z, Yang M, Wei H
KRAS-dependent cancer cells promote survival by producing exosomes enriched in Survivin.
1. Cancer Lett - published June 7, 2021
2. Chang WH, Thi Nguyen TT, Hsu CH, Bryant KL, Kim HJ, Ying H, Erickson JW, Der CJ, Cerione RA, Antonyak MA
Physical Activity as a Predictor of Cognitive Decline in an Elderly Essential Tremor Cohort: A Prospective, Longitudinal Study.
1. Front Neurol - published June 7, 2021
2. Radler KH, Chapman S, Zdrodowska MA, Dowd HN, Liu X, Huey ED, Cosentino S, Louis ED
Altered selection on a single self-ligand promotes susceptibility to organ-specific T cell infiltration.
1. J Exp Med - published June 7, 2021
2. Klawon DEJ, Gilmore DC, Leonard JD, Miller CH, Chao JL, Walker MT, Duncombe RK, Tung KS, Adams EJ, Savage PA
3D Printed frames to enable reuse and improve the fit of N95 and KN95 respirators.
1. BMC Biomed Eng - published June 7, 2021
2. McAvoy M, Bui AN, Hansen C, Plana D, Said JT, Yu Z, Yang H, Freake J, Van C, Krikorian D, Cramer A, Smith L, Jiang L, Lee KJ, Li SJ, Beller B, Huggins K, Short MP, Yu SH, Mostaghimi A, Sorger PK, LeBoeuf NR
A Trimeric Hydrophobic Zipper Mediates the Intramembrane Assembly of SARS-CoV-2 Spike.
1. J Am Chem Soc - published June 4, 2021
2. Fu Q, Chou JJ
Structural basis of successive adenosine modifications by the conserved ribosomal methyltransferase KsgA.
1. Nucleic Acids Res - published June 4, 2021
2. Stephan NC, Ries AB, Boehringer D, Ban N
Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates.
1. PLoS Pathog - published June 4, 2021
2. Cai F, Chen WH, Wu W, Jones JA, Choe M, Gohain N, Shen X, LaBranche C, Eaton A, Sutherland L, Lee EM, Hernandez GE, Wu NR, Scearce R, Seaman MS, Moody MA, Santra S, Wiehe K, Tomaras GD, Wagh K, Korber B, Bonsignori M, Montefiori DC, Haynes BF, de Val N, Joyce MG, Saunders KO
Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins.
1. Nat Rev Mol Cell Biol - published June 4, 2021
2. Jia N, Patel DJ
SARS-CoV-2 proteins and anti-COVID-19 drugs induce lytic reactivation of an oncogenic virus.
1. Commun Biol - published June 3, 2021
2. Chen J, Dai L, Barrett L, James J, Plaisance-Bonstaff K, Post SR, Qin Z
From the Three-Dimensional Structure of Phosphotriesterase.
1. Biochemistry - published June 3, 2021
2. Holden HM, Raushel FM
Structural Characterization of Endogenous Tuberous Sclerosis Protein Complex Revealed Potential Polymeric Assembly.
1. Biochemistry - published June 3, 2021
2. Dai DL, Hasan SMN, Woollard G, Abbas YM, Bueler SA, Julien JP, Rubinstein JL, Mazhab-Jafari MT
Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis.
1. Elife - published June 3, 2021
2. Kern N, Dong R, Douglas S, Vale RD, Morrissey MA
The to and fro of Rho.
1. Structure - published June 3, 2021
2. Westover KD
Dimerization of Cadherin-11 involves multi-site coupled unfolding and strand swapping.
1. Structure - published June 2, 2021
2. Koss H, Honig B, Shapiro L, Palmer AG 3rd
Repression by the Arabidopsis TOPLESS corepressor requires association with the core Mediator complex.
1. Elife - published June 2, 2021
2. Leydon AR, Wang W, Gala HP, Gilmour S, Juarez-Solis S, Zahler ML, Zemke JE, Zheng N, Nemhauser JL
The nonreceptor tyrosine kinase SRMS inhibits autophagy and promotes tumor growth by phosphorylating the scaffolding protein FKBP51.
1. PLoS Biol - published June 2, 2021
2. Park JM, Yang SW, Zhuang W, Bera AK, Liu Y, Gurbani D, von Hoyningen-Huene SJ, Sakurada SM, Gan H, Pruett-Miller SM, Westover KD, Potts MB
Characterization of an aminotransferase from Acanthamoeba polyphaga Mimivirus.
1. Protein Sci - published June 2, 2021
2. Seltzner CA, Ferek JD, Thoden JB, Holden HM
Large Clostridial Toxins: Mechanisms and Roles in Disease.
1. Microbiol Mol Biol Rev - published June 2, 2021
2. Orrell KE, Melnyk RA
Identification and validation of selective deubiquitinase inhibitors.
1. Cell Chem Biol - published June 2, 2021
2. Varca AC, Casalena D, Chan WC, Hu B, Magin RS, Roberts RM, Liu X, Zhu H, Seo HS, Dhe-Paganon S, Marto JA, Auld D, Buhrlage SJ
In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains.
1. Nature - published June 2, 2021
2. Chen RE, Winkler ES, Case JB, Aziati ID, Bricker TL, Joshi A, Darling TL, Ying B, Errico JM, Shrihari S, VanBlargan LA, Xie X, Gilchuk P, Zost SJ, Droit L, Liu Z, Stumpf S, Wang D, Handley SA, Stine WB Jr, Shi PY, Davis-Gardner ME, Suthar MS, Knight MG, Andino R, Chiu CY, Ellebedy AH, Fremont DH, Whelan SPJ, Crowe JE Jr, Purcell L, Corti D, Boon ACM, Diamond MS
Key computational findings reveal proton transfer as driving the functional cycle in the phosphate transporter PiPT.
1. Proc Natl Acad Sci U S A - published June 2, 2021
2. Liu Y, Li C, Gupta M, Verma N, Johri AK, Stroud RM, Voth GA
An Overview of Microcrystal Electron Diffraction (MicroED).
1. Annu Rev Biochem - published June 2, 2021
2. Mu X, Gillman C, Nguyen C, Gonen T
A Fragment-Based Approach to Discovery of RAGE Inhibitors.
1. Proteins - published June 2, 2021
2. Kozlyuk N, Gilston BA, Salay LE, Gogliotti RD, Christov PP, Kim K, Ovee M, Waterson AG, Chazin WJ
Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface.
1. J Clin Invest - published June 2, 2021
2. Zost SJ, Dong J, Gilchuk IM, Gilchuk P, Thornburg NJ, Bangaru S, Kose N, Finn JA, Bombardi R, Soto C, Chen EC, Nargi RS, Sutton RE, Irving RP, Suryadevara N, Westover JB, Carnahan RH, Turner HL, Li S, Ward AB, Crowe JE Jr
Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal.
1. mBio - published June 2, 2021
2. Zheng Y, Schubert HL, Singh PK, Martins LJ, Engelman AN, D'Orso I, Hill CP, Planelles V
Dph3 Enables Aerobic Diphthamide Biosynthesis by Donating One Iron Atom to Transform a [3Fe-4S] to a [4Fe-4S] Cluster in Dph1-Dph2.
1. J Am Chem Soc - published June 2, 2021
2. Zhang Y, Su D, Dzikovski B, Majer SH, Coleman R, Chandrasekaran S, Fenwick MK, Crane BR, Lancaster KM, Freed JH, Lin H
Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization.
1. Commun Biol - published June 2, 2021
2. Stüber JC, Richter CP, Bellón JS, Schwill M, König I, Schuler B, Piehler J, Plückthun A
Single-molecule binding characterization of primosomal protein PriA involved in replication restart.
1. Phys Chem Chem Phys - published June 2, 2021
2. Lee TY, Li YC, Lin MG, Hsiao CD, Li HW
Exploring the druggability of conserved RNA regulatory elements in the SARS-CoV-2 genome.
1. Angew Chem Int Ed Engl - published June 2, 2021
2. Sreeramulu S, Richter C, Berg H, Wirtz Martin MA, Ceylan B, Matzel T, Adam J, Altincekic N, Azzaoui K, Bains JK, Blommers MJJ, Ferner J, Fürtig B, Göbel M, Grün JT, Hengesbach M, Hohmann KF, Hymon D, Knezic B, Martins J, Mertinkus KR, Niesteruk A, Peter SA, Pyper DJ, Qureshi NS, Scheffer U, Schlundt A, Schnieders R, Stirnal E, Sudakov A, Tröster A, Vögele J, Wacker A, Weigand JE, Wirmer-Bartoschek J, Wöhnert J, Schwalbe H
Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils.
1. Nat Commun - published June 2, 2021
2. Zhao R, Dai H, Arias RJ, De Blas GA, Orta G, Pavarotti MA, Shen R, Perozo E, Mayorga LS, Darszon A, Goldstein SAN
Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs.
1. Nat Struct Mol Biol - published June 2, 2021
2. Kern DM, Sorum B, Mali SS, Hoel CM, Sridharan S, Remis JP, Toso DB, Kotecha A, Bautista DM, Brohawn SG
Correction to 'Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy'.
1. Nucleic Acids Res - published June 2, 2021
2. Wacker A, Weigand JE, Akabayov SR, Altincekic N, Bains JK, Banijamali E, Binas O, Castillo-Martinez J, Cetiner E, Ceylan B, Chiu LY, Davila-Calderon J, Dhamotharan K, Duchardt-Ferner E, Ferner J, Frydman L, Fürtig B, Gallego J, Grün JT, Hacker C, Haddad C, Hähnke M, Hengesbach M, Hiller F, Hohmann KF, Hymon D, de Jesus V, Jonker H, Keller H, Knezic B, Landgraf T, Löhr F, Luo L, Mertinkus KR, Muhs C, Novakovic M, Oxenfarth A, Palomino-Schätzlein M, Petzold K, Peter SA, Pyper DJ, Qureshi NS, Riad M, Richter C, Saxena K, Schamber T, Scherf T, Schlagnitweit J, Schlundt A, Schnieders R, Schwalbe H, Simba-Lahuasi A, Sreeramulu S, Stirnal E, Sudakov A, Tants JN, Tolbert BS, Vögele J, Weiß L, Wirmer-Bartoschek J, Wirtz Martin MA, Wöhnert J, Zetzsche H
Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease.
1. Structure - published June 2, 2021
2. Deshmukh MG, Ippolito JA, Zhang CH, Stone EA, Reilly RA, Miller SJ, Jorgensen WL, Anderson KS
Rapid, reliable, and reproducible cell fusion assay to quantify SARS-Cov-2 spike interaction with hACE2.
1. PLoS Pathog - published June 2, 2021
2. Zhao M, Su PY, Castro DA, Tripler TN, Hu Y, Cook M, Ko AI, Farhadian SF, Israelow B, Dela Cruz CS, Xiong Y, Sutton RE, Yale IMPACT Research Team.
"Just in Time": The Role of Cryo-Electron Microscopy in Combating Recent Pandemics.
1. Biochemistry - published June 2, 2021
2. Frank J
Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2.
1. ACS Infect Dis - published June 1, 2021
2. Biering SB, Van Dis E, Wehri E, Yamashiro LH, Nguyenla X, Dugast-Darzacq C, Graham TGW, Stroumza JR, Golovkine GR, Roberts AW, Fines DM, Spradlin JN, Ward CC, Bajaj T, Dovala D, Schulze-Gamen U, Bajaj R, Fox DM, Ott M, Murthy N, Nomura DK, Schaletzky J, Stanley SA
Molecular basis of CD-NTase nucleotide selection in CBASS anti-phage defense.
1. Cell Rep - published June 1, 2021
2. Govande AA, Duncan-Lowey B, Eaglesham JB, Whiteley AT, Kranzusch PJ
SIGLEC-3 (CD33) serves as an immune checkpoint receptor for HBV infection.
1. J Clin Invest - published June 1, 2021
2. Tsai TY, Huang MT, Sung PS, Peng CY, Tao MH, Yang HI, Chang WC, Yang AS, Yu CM, Lin YP, Bau CY, Huang CJ, Pan MH, Wu CY, Hsiao CD, Yeh YH, Duan S, Paulson JC, Hsieh SL
The chemistry and biology of phosphatidylinositol 4-phosphate at the plasma membrane.
1. Bioorg Med Chem - published June 1, 2021
2. Batrouni AG, Baskin JM
Molecular determinants for α-tubulin methylation by SETD2.
1. J Biol Chem - published June 1, 2021
2. Kearns S, Mason FM, Rathmell WK, Park IY, Walker C, Verhey KJ, Cianfrocco MA
Structural basis for the ARF GAP activity and specificity of the C9orf72 complex.
1. Nat Commun - published June 1, 2021
2. Su MY, Fromm SA, Remis J, Toso DB, Hurley JH
Stepwise maturation of the peptidyl transferase region of human mitoribosomes.
1. Nat Commun - published June 1, 2021
2. Lenarčič T, Jaskolowski M, Leibundgut M, Scaiola A, Schönhut T, Saurer M, Lee RG, Rackham O, Filipovska A, Ban N
SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.
1. ACS Med Chem Lett - published June 1, 2021
2. Zhou H, Bai L, Xu R, McEachern D, Chinnaswamy K, Li R, Wen B, Wang M, Yang CY, Meagher JL, Sun D, Stuckey JA, Wang S
Structural interactions define assembly adapter function of a type II secretion system pseudopilin.
1. Structure - published June 1, 2021
2. Escobar CA, Douzi B, Ball G, Barbat B, Alphonse S, Quinton L, Voulhoux R, Forest KT
Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing.
1. Cell - published June 1, 2021
2. Kober DL, Radhakrishnan A, Goldstein JL, Brown MS, Clark LD, Bai XC, Rosenbaum DM
Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation.
1. J Biol Chem - published June 1, 2021
2. Wu K, Wu H, Lyu W, Kim Y, Furdui CM, Anderson KS, Koleske AJ
Selective Imaging of Lung Macrophages Using [¹¹C]PBR28-Based Positron Emission Tomography.
1. Mol Imaging Biol - published June 1, 2021
2. Chen DL, Agapov E, Wu K, Engle JT, Solingapuram Sai KK, Arentson E, Spayd KJ, Moreland KT, Toth K, Byers DE, Pierce RA, Atkinson JJ, Laforest R, Gelman AE, Holtzman MJ
Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers.
1. Nat Commun - published June 1, 2021
2. Rujas E, Kucharska I, Tan YZ, Benlekbir S, Cui H, Zhao T, Wasney GA, Budylowski P, Guvenc F, Newton JC, Sicard T, Semesi A, Muthuraman K, Nouanesengsy A, Aschner CB, Prieto K, Bueler SA, Youssef S, Liao-Chan S, Glanville J, Christie-Holmes N, Mubareka S, Gray-Owen SD, Rubinstein JL, Treanor B, Julien JP
The effect of surgery on radiation necrosis in irradiated brain metastases: extent of resection and long-term clinical and radiographic outcomes.
1. J Neurooncol - published June 1, 2021
2. Newman WC, Goldberg J, Guadix SW, Brown S, Reiner AS, Panageas K, Beal K, Brennan CW, Tabar V, Young RJ, Moss NS
Deciphering Antifungal Drug Resistance in Pneumocystis jirovecii DHFR with Molecular Dynamics and Machine Learning.
1. J Chem Inf Model - published June 1, 2021
2. Leidner F, Kurt Yilmaz N, Schiffer CA
A Prevalent Focused Human Antibody Response to the Influenza Virus Hemagglutinin Head Interface.
1. mBio - published June 1, 2021
2. McCarthy KR, Lee J, Watanabe A, Kuraoka M, Robinson-McCarthy LR, Georgiou G, Kelsoe G, Harrison SC
Designed Ankyrin Repeat Proteins as Novel Binders for Ultrasound Molecular Imaging.
1. Ultrasound Med Biol - published June 1, 2021
2. Kosareva A, Punjabi M, Ochoa-Espinosa A, Xu L, Schaefer JV, Dreier B, Plückthun A, Kaufmann BA
Divergent evolution toward sex chromosome-specific gene regulation in Drosophila.
1. Genes Dev - published June 1, 2021
2. Villa R, Jagtap PKA, Thomae AW, Campos Sparr A, Forné I, Hennig J, Straub T, Becker PB
The linear ubiquitin chain assembly complex LUBAC generates heterotypic ubiquitin chains.
1. Elife - published June 1, 2021
2. Rodriguez Carvajal A, Grishkovskaya I, Gomez Diaz C, Vogel A, Sonn-Segev A, Kushwah MS, Schodl K, Deszcz L, Orban-Nemeth Z, Sakamoto S, Mechtler K, Kukura P, Clausen T, Haselbach D, Ikeda F
Molecular basis of mRNA transport by a kinesin-1-atypical tropomyosin complex.
1. Genes Dev - published June 1, 2021
2. Dimitrova-Paternoga L, Jagtap PKA, Cyrklaff A, Vaishali, Lapouge K, Sehr P, Perez K, Heber S, Löw C, Hennig J, Ephrussi A
Information-driven modeling of biomolecular complexes.
1. Curr Opin Struct Biol - published June 1, 2021
2. van Noort CW, Honorato RV, Bonvin AMJJ
Mapping electromechanical coupling pathways in voltage-gated ion channels: Challenges and the way forward.
1. J Mol Biol - published June 1, 2021
2. Cowgill J, Chanda B
Rapid assessment of DCLK1 inhibitors using a peptide substrate mobility shift assay.
1. STAR Protoc - published June 1, 2021
2. Liu Y, Westover KD
The evolution of interdependence in a four-way mealybug symbiosis.
1. Genome Biol Evol - published June 1, 2021
2. Garber AI, Kupper M, Laetsch DR, Weldon SR, Ladinsky MS, Bjorkman PJ, McCutcheon JP
Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action.
1. Nat Commun - published June 1, 2021
2. Kast F, Schwill M, Stüber JC, Pfundstein S, Nagy-Davidescu G, Rodríguez JMM, Seehusen F, Richter CP, Honegger A, Hartmann KP, Weber TG, Kroener F, Ernst P, Piehler J, Plückthun A
Hakai is required for stabilization of core components of the m⁶A mRNA methylation machinery.
1. Nat Commun - published June 1, 2021
2. Bawankar P, Lence T, Paolantoni C, Haussmann IU, Kazlauskiene M, Jacob D, Heidelberger JB, Richter FM, Nallasivan MP, Morin V, Kreim N, Beli P, Helm M, Jinek M, Soller M, Roignant JY
Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype.
1. Genet Med - published June 1, 2021
2. Polubothu S, Zecchin D, Al-Olabi L, Lionarons DA, Harland M, Horswell S, Thomas AC, Hunt L, Wlodarchak N, Aguilera P, Brand S, Bryant D, Carrera C, Chen H, Elgar G, Harwood CA, Howell M, Larue L, Loughlin S, MacDonald J, Malvehy J, Barberan SM, da Silva VM, Molina M, Morrogh D, Moulding D, Nsengimana J, Pittman A, Puig-Butillé JA, Parmar K, Sebire NJ, Scherer S, Stadnik P, Stanier P, Tell G, Waelchli R, Zarrei M, Puig S, Bataille V, Xing Y, Healy E, Moore GE, Di WL, Newton-Bishop J, Downward J, Kinsler VA
Pharmacological Advantage of SIRT2-Selective versus pan-SIRT1-3 Inhibitors.
1. ACS Chem Biol - published June 1, 2021
2. Hong JY, Fernandez I, Anmangandla A, Lu X, Bai JJ, Lin H
Finding the Ion in the RNA-Stack: Can Computational Models Accurately Predict Key Functional Elements in Large Macromolecular Complexes?
1. J Chem Inf Model - published June 1, 2021
2. Marcia M, Manigrasso J, De Vivo M
AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear.
1. Mol Ther Methods Clin Dev - published June 1, 2021
2. Ivanchenko MV, Hanlon KS, Hathaway DM, Klein AJ, Peters CW, Li Y, Tamvakologos PI, Nammour J, Maguire CA, Corey DP
Chaperone-mediated autophagy: a gatekeeper of neuronal proteostasis.
1. Autophagy - published June 1, 2021
2. Bourdenx M, Gavathiotis E, Cuervo AM
Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies.
1. Structure - published June 1, 2021
2. Cerutti G, Rapp M, Guo Y, Bahna F, Bimela J, Reddem ER, Yu J, Wang P, Liu L, Huang Y, Ho DD, Kwong PD, Sheng Z, Shapiro L
Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit.
1. J Infect Dis - published June 1, 2021
2. Hall MD, Anderson JM, Anderson A, Baker D, Bradner J, Brimacombe KR, Campbell EA, Corbett KS, Carter K, Cherry S, Chiang L, Cihlar T, de Wit E, Denison M, Disney M, Fletcher CV, Ford-Scheimer SL, Götte M, Grossman AC, Hayden FG, Hazuda DJ, Lanteri CA, Marston H, Mesecar AD, Moore S, Nwankwo JO, O'Rear J, Painter G, Saikatendu KS, Schiffer CA, Sheahan TP, Shi PY, Smyth HD, Sofia MJ, Weetall M, Weller SK, Whitley R, Fauci AS, Austin CP, Collins FS, Conley AJ, Davis MI
Crystal Structure of the [4Fe-4S] Cluster-Containing Adenosine-5'-phosphosulfate Reductase from Mycobacterium tuberculosis.
1. ACS Omega - published June 1, 2021
2. Feliciano PR, Carroll KS, Drennan CL
Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19.
1. Sci Rep - published June 1, 2021
2. Le BL, Andreoletti G, Oskotsky T, Vallejo-Gracia A, Rosales R, Yu K, Kosti I, Leon KE, Bunis DG, Li C, Kumar GR, White KM, García-Sastre A, Ott M, Sirota M
Antigen-Presenting, Self-Assembled Protein Nanobarrels as an Adjuvant-Free Vaccine Platform against Influenza Virus.
1. ACS Nano - published June 1, 2021
2. Kang S, Kim Y, Shin Y, Song JJ, Jon S
Random access DNA memory using Boolean search in an archival file storage system.
1. Nat Mater - published June 1, 2021
2. Banal JL, Shepherd TR, Berleant J, Huang H, Reyes M, Ackerman CM, Blainey PC, Bathe M
Early Returns on Small Molecule Therapeutics for SARS-CoV-2.
1. ACS Infect Dis - published June 1, 2021
2. Namchuk MN
Substrate and product complexes reveal mechanisms of Hedgehog acylation by HHAT.
1. Science - published June 1, 2021
2. Jiang Y, Benz TL, Long SB
Evolution of a virus-like architecture and packaging mechanism in a repurposed bacterial protein.
1. Science - published June 1, 2021
2. Tetter S, Terasaka N, Steinauer A, Bingham RJ, Clark S, Scott AJP, Patel N, Leibundgut M, Wroblewski E, Ban N, Stockley PG, Twarock R, Hilvert D
Characterization of SARS-CoV-2 N protein reveals multiple functional consequences of the C-terminal domain.
1. iScience - published June 1, 2021
2. Wu C, Qavi AJ, Hachim A, Kavian N, Cole AR, Moyle AB, Wagner ND, Sweeney-Gibbons J, Rohrs HW, Gross ML, Peiris JSM, Basler CF, Farnsworth CW, Valkenburg SA, Amarasinghe GK, Leung DW
Locating Macromolecular Assemblies in Cells by 2D Template Matching with cisTEM.
1. Elife - published June 1, 2021
2. Lucas BA, Himes BA, Xue L, Grant T, Mahamid J, Grigorieff N
Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain.
1. Commun Biol - published June 1, 2021
2. Javorsky A, Humbert PO, Kvansakul M
Complement Receptor 3 Forms a Compact High-Affinity Complex with iC3b.
1. J Immunol - published June 1, 2021
2. Jensen RK, Bajic G, Sen M, Springer TA, Vorup-Jensen T, Andersen GR
Ion channels: Intersection of Structure, Function, and Pharmacology.
1. J Mol Biol - published June 1, 2021
2. Moiseenkova-Bell V, Delemotte L, Minor DL Jr
Inroads into membrane physiology through transport nanomachines.
1. J Mol Biol - published June 1, 2021
2. Stockbridge RB, Gaudet R, Grabe M, Minor DL Jr
PspA adopts an ESCRT-III-like fold and remodels bacterial membranes.
1. Cell - published June 1, 2021
2. Junglas B, Huber ST, Heidler T, Schlösser L, Mann D, Hennig R, Clarke M, Hellmann N, Schneider D, Sachse C