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43 Member Publications for August

Previous Month

High-Throughput Screening of a Functional Human CXCL12-CXCR4 Signaling Axis in a Genetically Modified S. cerevisiae: Discovery of a Novel Up-Regulator of CXCR4 Activity.
1. Front Mol Biosci - published August 9, 2020
2. Murphy JW, Rajasekaran D, Merkel J, Skeens E, Keeler C, Hodsdon ME, Lisi GP, Lolis E
The Effects of Framework Mutations at the Variable Domain Interface on Antibody Affinity Maturation in an HIV-1 Broadly Neutralizing Antibody Lineage.
1. Front Immunol - published August 9, 2020
2. Zhou JO, Zaidi HA, Ton T, Fera D
1H, 13C, and 15N backbone chemical shift assignments of the nucleic acid-binding domain of SARS-CoV-2 non-structural protein 3e.
1. Biomol NMR Assign - published August 8, 2020
2. Korn SM, Dhamotharan K, Fürtig B, Hengesbach M, Löhr F, Qureshi NS, Richter C, Saxena K, Schwalbe H, Tants JN, Weigand JE, Wöhnert J, Schlundt A
Structural insights into the Ca2+-dependent gating of the human mitochondrial calcium uniporter.
1. Elife - published August 7, 2020
2. Wang Y, Han Y, She J, Nguyen NX, Mootha VK, Bai XC, Jiang Y
Transient intracellular acidification regulates the core transcriptional heat shock response.
1. Elife - published August 7, 2020
2. Triandafillou CG, Katanski CD, Dinner AR, Drummond DA
Structure, function and assembly of the long, flexible tail of siphophages.
1. Curr Opin Virol - published August 7, 2020
2. Linares R, Arnaud CA, Degroux S, Schoehn G, Breyton C
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.
1. Elife - published August 7, 2020
2. Tsutsumi N, Mukherjee S, Waghray D, Janda CY, Jude KM, Miao Y, Burg JS, Aduri NG, Kossiakoff AA, Gati C, Garcia KC
Nuclear Egress of Herpesviruses.
1. Curr Issues Mol Biol - published August 7, 2020
2. Draganova EB, Thorsen MK, Heldwein EE
A molecular pore spans the double membrane of the coronavirus replication organelle.
1. Science - published August 6, 2020
2. Wolff G, Limpens RWAL, Zevenhoven-Dobbe JC, Laugks U, Zheng S, de Jong AWM, Koning RI, Agard DA, Grünewald K, Koster AJ, Snijder EJ, Bárcena M
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2.
1. Proc Natl Acad Sci U S A - published August 6, 2020
2. Kang YL, Chou YY, Rothlauf PW, Liu Z, Soh TK, Cureton D, Case JB, Chen RE, Diamond MS, Whelan SPJ, Kirchhausen T
Primary Role of the Nucleosome.
1. Mol Cell - published August 6, 2020
2. Kornberg RD, Lorch Y
A cross-reactive antibody protects against Ross River virus musculoskeletal disease despite rapid neutralization escape in mice.
1. PLoS Pathog - published August 6, 2020
2. Fox JM, Huang L, Tahan S, Powell LA, Crowe JE Jr, Wang D, Diamond MS
SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness.
1. Nature - published August 5, 2020
2. Corbett KS, Edwards DK, Leist SR, Abiona OM, Boyoglu-Barnum S, Gillespie RA, Himansu S, Schäfer A, Ziwawo CT, DiPiazza AT, Dinnon KH, Elbashir SM, Shaw CA, Woods A, Fritch EJ, Martinez DR, Bock KW, Minai M, Nagata BM, Hutchinson GB, Wu K, Henry C, Bahi K, Garcia-Dominguez D, Ma L, Renzi I, Kong WP, Schmidt SD, Wang L, Zhang Y, Phung E, Chang LA, Loomis RJ, Altaras NE, Narayanan E, Metkar M, Presnyak V, Liu C, Louder MK, Shi W, Leung K, Yang ES, West A, Gully KL, Stevens LJ, Wang N, Wrapp D, Doria-Rose NA, Stewart-Jones G, Bennett H, Alvarado GS, Nason MC, Ruckwardt TJ, McLellan JS, Denison MR, Chappell JD, Moore IN, Morabito KM, Mascola JR, Baric RS, Carfi A, Graham BS
Optimizing the anti-tumor efficacy of protein-drug conjugates by engineering the molecular size and half-life.
1. J Control Release - published August 5, 2020
2. Brandl F, Busslinger S, Zangemeister-Wittke U, Plückthun A
interferENZY: A Web-Based Tool for Enzymatic Assay Validation and Standardized Kinetic Analysis.
1. J Mol Biol - published August 5, 2020
2. Pinto MF, Baici A, Pereira PJB, Macedo-Ribeiro S, Pastore A, Rocha F, Martins PM
The Enzyme-Free Release of Nucleotides from Phosphoramidates Depends Strongly on the Amino Acid.
1. Angew Chem Int Ed Engl - published August 5, 2020
2. Richert C, Jovanovic D, Tremmel P, Pallan SP, Egli M
CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis.
1. Immunity - published August 4, 2020
2. Morrissey MA, Kern N, Vale RD
Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing.
1. Cell Chem Biol - published August 4, 2020
2. Liu Y, Ferguson FM, Li L, Kuljanin M, Mills CE, Subramanian K, Harshbarger W, Gondi S, Wang J, Sorger PK, Mancias JD, Gray NS, Westover KD
Synthetic nanobodies as angiotensin receptor blockers.
1. Proc Natl Acad Sci U S A - published August 4, 2020
2. McMahon C, Staus DP, Wingler LM, Wang J, Skiba MA, Elgeti M, Hubbell WL, Rockman HA, Kruse AC, Lefkowitz RJ
Anti-influenza H7 human antibody targets antigenic site in hemagglutinin head domain interface.
1. J Clin Invest - published August 4, 2020
2. Dong J, Gilchuk I, Li S, Irving R, Goff MT, Turner HL, Ward AB, Carnahan RH, Crowe JE Jr
Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature.
1. Cell Rep - published August 4, 2020
2. Cheng C, Duan H, Xu K, Chuang GY, Corrigan AR, Geng H, O'Dell S, Ou L, Chambers M, Changela A, Chen X, Foulds KE, Sarfo EK, Jafari AJ, Hill KR, Kong R, Liu K, Todd JP, Tsybovsky Y, Verardi R, Wang S, Wang Y, Wu W, Zhou T, VRC Production Program., Arnold FJ, Doria-Rose NA, Koup RA, McDermott AB, Scorpio DG, Worobey M, Shapiro L, Mascola JR, Kwong PD
Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step.
1. PLoS Pathog - published August 3, 2020
2. Ye X, Su H, Wrapp D, Freed DC, Li F, Yuan Z, Tang A, Li L, Ku Z, Xiong W, Jaijyan D, Zhu H, Wang D, McLellan JS, Zhang N, Fu TM, An Z
A proof of concept for biomarker-guided targeted therapy against ovarian cancer based on patient-derived tumor xenografts.
1. Cancer Res - published August 3, 2020
2. Palmer AC, Plana D, Gao H, Korn JM, Yang G, Green J, Zhang X, Velazquez R, McLaughlin ME, Ruddy DA, Kowal C, Goldovitz J, Bullock C, Rivera S, Rakiec DP, Elliott G, Fordjour P, Meyer R, Loo A, Kurth E, Engelman JA, Bitter H, Sellers WR, Williams JA, Sorger PK
Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
1. Nat Struct Mol Biol - published August 3, 2020
2. Mahalingan KK, Keith Keenen E, Strickland M, Li Y, Liu Y, Ball HL, Tanner ME, Tjandra N, Roll-Mecak A
Integrated pipeline for the accelerated discovery of antiviral antibody therapeutics.
1. Nat Biomed Eng - published August 3, 2020
2. Gilchuk P, Bombardi RG, Erasmus JH, Tan Q, Nargi R, Soto C, Abbink P, Suscovich TJ, Durnell LA, Khandhar A, Archer J, Liang J, Fouch ME, Davidson E, Doranz BJ, Jones T, Larson E, Ertel S, Granger B, Fuerte-Stone J, Roy V, Broge T, Linnekin TC, Linde CH, Gorman MJ, Nkolola J, Alter G, Reed SG, Barouch DH, Diamond MS, Crowe JE Jr, Van Hoeven N, Thackray LB, Carnahan RH
Structural annotation of the conserved carbohydrate esterase vb_24B_21 from Shiga toxin-encoding bacteriophage Φ24B.
1. J Struct Biol - published August 3, 2020
2. Franke B, Veses-Garcia M, Diederichs K, Allison H, Rigden DJ, Mayans O
Domain cross-talk in regulation of histone modifications: Molecular mechanisms and targeting opportunities.
1. Curr Opin Chem Biol - published August 3, 2020
2. Longbotham JE, Zhang MY, Fujimori DG
The Structural Determinants of PH Domain-Mediated Regulation of Akt Revealed by Segmental Labeling.
1. Elife - published August 3, 2020
2. Chu N, Viennet T, Bae H, Salguero A, Boeszoermenyi A, Arthanari H, Cole PA
The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma.
1. Nat Struct Mol Biol - published August 3, 2020
2. McBride MJ, Mashtalir N, Winter EB, Dao HT, Filipovski M, D'Avino AR, Seo HS, Umbreit NT, St Pierre R, Valencia AM, Qian K, Zullow HJ, Jaffe JD, Dhe-Paganon S, Muir TW, Kadoch C
Functional characterization of a PROTAC directed against BRAF mutant V600E.
1. Nat Chem Biol - published August 1, 2020
2. Posternak G, Tang X, Maisonneuve P, Jin T, Lavoie H, Daou S, Orlicky S, Goullet de Rugy T, Caldwell L, Chan K, Aman A, Prakesch M, Poda G, Mader P, Wong C, Maier S, Kitaygorodsky J, Larsen B, Colwill K, Yin Z, Ceccarelli DF, Batey RA, Taipale M, Kurinov I, Uehling D, Wrana J, Durocher D, Gingras AC, Al-Awar R, Therrien M, Sicheri F
Model-based analysis of chromatin interactions from dCas9-Based CAPTURE-3C-seq.
1. PLoS One - published August 1, 2020
2. Chen Y, Wang Y, Liu X, Xu J, Zhang MQ
Attaining atomic resolution from in situ data collection at room temperature using counter-diffusion-based low-cost microchips.
1. Acta Crystallogr D Struct Biol - published August 1, 2020
2. Gavira JA, Rodriguez-Ruiz I, Martinez-Rodriguez S, Basu S, Teychené S, McCarthy AA, Mueller-Dieckman C
Fragment-based determination of a proteinase K structure from MicroED data using ARCIMBOLDO_SHREDDER.
1. Acta Crystallogr D Struct Biol - published August 1, 2020
2. Richards LS, Millán C, Miao J, Martynowycz MW, Sawaya MR, Gonen T, Borges RJ, Usón I, Rodriguez JA
Fenretinide induces a new form of dynamin-dependent cell death in pediatric sarcoma.
1. Cell Death Differ - published August 1, 2020
2. Brack E, Wachtel M, Wolf A, Kaech A, Ziegler U, Schäfer BW
Characterization of missense mutations in the signal peptide and propeptide of FIX in hemophilia B by a cell-based assay.
1. Blood Adv - published August 1, 2020
2. Gao W, Xu Y, Liu H, Gao M, Cao Q, Wang Y, Cui L, Huang R, Shen Y, Li S, Yang H, Chen Y, Li C, Yu H, Li W, Shen G
Primate lentiviruses require Inositol hexakisphosphate (IP6) or inositol pentakisphosphate (IP5) for the production of viral particles.
1. PLoS Pathog - published August 1, 2020
2. Ricana CL, Lyddon TD, Dick RA, Johnson MC
The structural basis of Bcl-2 mediated cell death regulation in Hydra.
1. Biochem J - published August 1, 2020
2. Banjara S, D Sa J, Hinds MG, Kvansakul M
Antagonistic anti-LILRB1 monoclonal antibody regulates antitumor functions of natural killer cells.
1. J Immunother Cancer - published August 1, 2020
2. Chen H, Chen Y, Deng M, John S, Gui X, Kansagra A, Chen W, Kim J, Lewis C, Wu G, Xie J, Zhang L, Huang R, Liu X, Arase H, Huang Y, Yu H, Luo W, Xia N, Zhang N, An Z, Zhang CC
Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo.
1. Elife - published August 1, 2020
2. Fernandes RA, Li C, Wang G, Yang X, Savvides CS, Glassman CR, Dong S, Luxenberg E, Sibener LV, Birnbaum ME, Benoist C, Mathis D, Garcia KC
The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment.
1. Elife - published August 1, 2020
2. Shi X, Chang C, Yokom AL, Jensen LE, Hurley JH
Time-resolved cryo-EM using Spotiton.
1. Nat Methods - published August 1, 2020
2. Dandey VP, Budell WC, Wei H, Bobe D, Maruthi K, Kopylov M, Eng ET, Kahn PA, Hinshaw JE, Kundu N, Nimigean CM, Fan C, Sukomon N, Darst SA, Saecker RM, Chen J, Malone B, Potter CS, Carragher B
Hydroxamic Acids Immobilized on Resins (HAIRs): A Toolbox for the Synthesis of Dual-Targeting HDAC Inhibitors and HDAC Degraders (PROTACs).
1. Angew Chem Int Ed Engl - published August 1, 2020
2. Sinatra L, Bandolik JJ, Roatsch M, Sönnichsen M, Schoeder CT, Hamacher A, Schoeler A, Borkhardt A, Meiler J, Bhatia S, Kassack MU, Hansen FK
The Helicobacter pylori Cag Type IV Secretion System.
1. Trends Microbiol - published August 1, 2020
2. Cover TL, Lacy DB, Ohi MD