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123 Member Publications for May

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Molecular probes of spike ectodomain and its subdomains for SARS-CoV-2 variants, Alpha through Omicron.
1. PLoS One - published May 24, 2022
2. Teng IT, Nazzari AF, Choe M, Liu T, Oliveira de Souza M, Petrova Y, Tsybovsky Y, Wang S, Zhang B, Artamonov M, Madan B, Huang A, Lopez Acevedo SN, Pan X, Ruckwardt TJ, DeKosky BJ, Mascola JR, Misasi J, Sullivan NJ, Zhou T, Kwong PD
AreTomo: An integrated software package for automated marker-free, motion-corrected cryo-electron tomographic alignment and reconstruction.
1. J Struct Biol X - published May 23, 2022
2. Zheng S, Wolff G, Greenan G, Chen Z, Faas FGA, Bárcena M, Koster AJ, Cheng Y, Agard DA
SARS-CoV-2 Susceptibility and ACE2 Gene Variations Within Diverse Ethnic Backgrounds.
1. Front Genet - published May 16, 2022
2. Vadgama N, Kreymerman A, Campbell J, Shamardina O, Brugger C, Research Consortium GE, Deaconescu AM, Lee RT, Penkett CJ, Gifford CA, Mercola M, Nasir J, Karakikes I
A Surface Exposed, Two-Domain Lipoprotein Cargo of a Type XI Secretion System Promotes Colonization of Host Intestinal Epithelia Expressing Glycans.
1. Front Microbiol - published May 16, 2022
2. Grossman AS, Escobar CA, Mans EJ, Mucci NC, Mauer TJ, Jones KA, Moore CC, Abraham PE, Hettich RL, Schneider L, Campagna SR, Forest KT, Goodrich-Blair H
mTOR regulates aerobic glycolysis through NEAT1 and nuclear paraspeckle-mediated mechanism in hepatocellular carcinoma.
1. Theranostics - published May 13, 2022
2. Zhang H, Su X, Burley SK, Zheng XFS
Structural Basis for Allostery in PLP-dependent Enzymes.
1. Front Mol Biosci - published May 13, 2022
2. Tran JU, Brown BL
Editorial: Targeting Bruton Tyrosine Kinase.
1. Front Cell Dev Biol - published May 13, 2022
2. Brunner C, Betzler AC, Brown JR, Andreotti AH, Grassilli E
Cryo-EM structure of the plant 26S proteasome.
1. Plant Commun - published May 9, 2022
2. Kandolf S, Grishkovskaya I, Belačić K, Bolhuis DL, Amann S, Foster B, Imre R, Mechtler K, Schleiffer A, Tagare HD, Zhong ED, Meinhart A, Brown NG, Haselbach D
IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia.
1. Nat Cancer - published May 9, 2022
2. Aubrey BJ, Cutler JA, Bourgeois W, Donovan KA, Gu S, Hatton C, Perlee S, Perner F, Rahnamoun H, Theall ACP, Henrich JA, Zhu Q, Nowak RP, Kim YJ, Parvin S, Cremer A, Olsen SN, Eleuteri NA, Pikman Y, McGeehan GM, Stegmaier K, Letai A, Fischer ES, Liu XS, Armstrong SA
Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors.
1. Nat Commun - published May 9, 2022
2. Beyett TS, To C, Heppner DE, Rana JK, Schmoker AM, Jang J, De Clercq DJH, Gomez G, Scott DA, Gray NS, Jänne PA, Eck MJ
Synthesis and Structure-Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold.
1. Eur J Med Chem - published May 8, 2022
2. Li Z, Ishida R, Liu Y, Wang J, Li Y, Gao Y, Jiang J, Che J, Sheltzer JM, Robers MB, Zhang T, Westover KD, Nabet B, Gray NS
Dynamics of protein kinases and pseudokinases by HDX-MS.
1. Methods Enzymol - published May 7, 2022
2. Sheetz JB, Lemmon MA, Tsutsui Y
Structural and biophysical characterization of Tribbles homolog 1.
1. Methods Enzymol - published May 7, 2022
2. Jamieson SA, McMillan HD, Mace PD
Methods for discovering catalytic activities for pseudokinases.
1. Methods Enzymol - published May 7, 2022
2. Black MH, Gradowski M, Pawłowski K, Tagliabracci VS
A suite of in vitro and in vivo assays for monitoring the activity of the pseudokinase Bud32.
1. Methods Enzymol - published May 7, 2022
2. Beenstock J, Ona SM, Sicheri F
Structural mapping of antibody landscapes to human betacoronavirus spike proteins.
1. Sci Adv - published May 6, 2022
2. Bangaru S, Antanasijevic A, Kose N, Sewall LM, Jackson AM, Suryadevara N, Zhan X, Torres JL, Copps J, de la Peña AT, Crowe JE Jr, Ward AB
Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients.
1. Front Microbiol - published May 6, 2022
2. Dai L, Lu YC, Chen J, Plaisance-Bonstaff K, Mu S, Forrest JC, Whitby D, Post SR, Qin Z
Recall of B cell memory depends on relative locations of prime and boost immunization.
1. Sci Immunol - published May 6, 2022
2. Kuraoka M, Yeh CH, Bajic G, Kotaki R, Song S, Windsor I, Harrison SC, Kelsoe G
Racial and Ethnic Disparities Plague the Chain of Survival Even After Return of Spontaneous Circulation.
1. Resuscitation - published May 6, 2022
2. Bhardwaj A, Gaieski DF
Heterogeneity of the GFP fitness landscape and data-driven protein design.
1. Elife - published May 5, 2022
2. Gonzalez Somermeyer L, Fleiss A, Mishin AS, Bozhanova NG, Igolkina AA, Meiler J, Alaball Pujol ME, Putintseva EV, Sarkisyan KS, Kondrashov FA
Extracellular domain of PepT1 interacts with TM1 to facilitate substrate transport.
1. Structure - published May 5, 2022
2. Shen J, Hu M, Fan X, Ren Z, Portioli C, Yan X, Rong M, Zhou M
Systematic characterization of gene function in the photosynthetic alga Chlamydomonas reinhardtii.
1. Nat Genet - published May 5, 2022
2. Fauser F, Vilarrasa-Blasi J, Onishi M, Ramundo S, Patena W, Millican M, Osaki J, Philp C, Nemeth M, Salomé PA, Li X, Wakao S, Kim RG, Kaye Y, Grossman AR, Niyogi KK, Merchant SS, Cutler SR, Walter P, Dinneny JR, Jonikas MC, Jinkerson RE
Modulation of autoimmune diabetes by ENU-induced mutations in non-obese diabetic mice.
1. Dis Model Mech - published May 3, 2022
2. Chatenoud L, Marquet C, Valette F, Scott L, Quan J, Bu CH, Hildebrand S, Moresco EMY, Bach JF, Beutler B
A neutralizing antibody target in early HIV-1 infection was recapitulated in rhesus macaques immunized with the transmitted/founder envelope sequence.
1. PLoS Pathog - published May 3, 2022
2. Welbourn S, Chakraborty S, Yang JE, Gleinich AS, Gangadhara S, Khan S, Ferrebee C, Yagnik B, Burton S, Charles T, Smith SA, Williams D, Mopuri R, Upadhyay AA, Thompson J, Price MA, Wang S, Qin Z, Shen X, Williams LD, Eisel N, Peters T, Zhang L, Kilembe W, Karita E, Tomaras GD, Bosinger SE, Amara RR, Azadi P, Wright ER, Gnanakaran S, Derdeyn CA
Synergy of a STING agonist and an IL-2 superkine in cancer immunotherapy against MHC I-deficient and MHC I⁺ tumors.
1. Proc Natl Acad Sci U S A - published May 3, 2022
2. Wolf NK, Blaj C, Picton LK, Snyder G, Zhang L, Nicolai CJ, Ndubaku CO, McWhirter SM, Garcia KC, Raulet DH
RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice.
1. Proc Natl Acad Sci U S A - published May 3, 2022
2. Zhong X, Choi JH, Hildebrand S, Ludwig S, Wang J, Nair-Gill E, Liao TC, Moresco JJ, Liu A, Quan J, Sun Q, Zhang D, Zhan X, Choi M, Li X, Wang J, Gallagher T, Moresco EMY, Beutler B
Structural Basis for Control of Methylation Extent in Polyketide Synthase Metal-Dependent C-Methyltransferases.
1. ACS Chem Biol - published May 2, 2022
2. Lao Y, Skiba MA, Chun SW, Narayan ARH, Smith JL
Planar 2D wireframe DNA origami.
1. Sci Adv - published May 2, 2022
2. Wang X, Li S, Jun H, John T, Zhang K, Fowler H, Doye JPK, Chiu W, Bathe M
Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
1. PLoS Pathog - published May 2, 2022
2. Krischuns T, Isel C, Drncova P, Lukarska M, Pflug A, Paisant S, Navratil V, Cusack S, Naffakh N
The CD3ζ adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling.
1. J Exp Med - published May 2, 2022
2. Aguilar OA, Fong LK, Ishiyama K, DeGrado WF, Lanier LL
Comparison of Medical Cannabis Use Reported on a Confidential Survey vs Documented in the Electronic Health Record Among Primary Care Patients.
1. JAMA Netw Open - published May 2, 2022
2. Lapham GT, Matson TE, Carrell DS, Bobb JF, Luce C, Oliver MM, Ghitza UE, Hsu C, Browne KC, Binswanger IA, Campbell CI, Saxon AJ, Vandrey R, Schauer GL, Pacula RL, Horberg MA, Bailey SR, McClure EA, Bradley KA
Concise Synthesis of Tunicamycin V and Discovery of a Cytostatic DPAGT1 Inhibitor.
1. Angew Chem Int Ed Engl - published May 2, 2022
2. Mitachi K, Mingle D, Effah W, Sánchez-Ruiz A, Hevener KE, Narayanan R, Clemons WM Jr, Sarabia F, Kurosu M
Moyamoya disease: diagnosis and interventions.
1. Lancet Neurol - published May 2, 2022
2. Ihara M, Yamamoto Y, Hattori Y, Liu W, Kobayashi H, Ishiyama H, Yoshimoto T, Miyawaki S, Clausen T, Bang OY, Steinberg GK, Tournier-Lasserve E, Koizumi A
Sub-3-Å cryo-EM structure of RNA enabled by engineered homomeric self-assembly.
1. Nat Methods - published May 2, 2022
2. Liu D, Thélot FA, Piccirilli JA, Liao M, Yin P
Formation of thyroid hormone revealed by a cryo-EM structure of native bovine thyroglobulin.
1. Nat Commun - published May 2, 2022
2. Marechal N, Serrano BP, Zhang X, Weitz CJ
Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K⁺ channel TMEM175.
1. Elife - published May 2, 2022
2. Oh S, Marinelli F, Zhou W, Lee J, Choi HJ, Kim M, Faraldo-Gómez JD, Hite RK
Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice.
1. NPJ Vaccines - published May 2, 2022
2. Grigoryan L, Lee A, Walls AC, Lai L, Franco B, Arunachalam PS, Feng Y, Luo W, Vanderheiden A, Floyd K, Wrenn S, Pettie D, Miranda MC, Kepl E, Ravichandran R, Sydeman C, Brunette N, Murphy M, Fiala B, Carter L, Coffman RL, Novack D, Kleanthous H, O'Hagan DT, van der Most R, McLellan JS, Suthar M, Veesler D, King NP, Pulendran B
Role of the SWIRM Domain in Regulating the HAT Module of the SAGA Complex.
1. FASEB J - published May 1, 2022
2. Haile ST, Wolberger C
PDB-101: Molecular Explorations through Biology and Medicine.
1. FASEB J - published May 1, 2022
2. Zardecki C, Goodsell DS, Dutta S, Voigt M, Burley SK
SHIP164 is a Chorein Motif Lipid Transfer Protein that Controls Endosome-Golgi Membrane Traffic.
1. FASEB J - published May 1, 2022
2. Hanna MG, Suen P, Wu Y, Reinisch KM, De Camilli P
Flavivirus NS1: Structure and Function of an Enigmatic Virulence Factor.
1. FASEB J - published May 1, 2022
2. Smith JL
Folding state as the Decision Maker in Detecting Misfolded Proteins by Hsp70.
1. FASEB J - published May 1, 2022
2. Karunanayake CS, DelVecchio R, Page RC
New insights into regulation of P-Rex1 autoinhibition.
1. FASEB J - published May 1, 2022
2. Ravala SK, Li S, Chen CL, Cianfrocco MA, Cash JN, Tesmer JJG
Structural basis for specific activation of the Rab11 GTPase by the TRAPPII complex.
1. FASEB J - published May 1, 2022
2. Bagde SR, Fromme JC
Chemical Tools for Understanding Phosphatidic Acid Signaling.
1. FASEB J - published May 1, 2022
2. Baskin JM
PLEKHA5 Regulates Mitotic Progression by Promoting APC/C Localization to Microtubules.
1. FASEB J - published May 1, 2022
2. Cao X, Shami Shah A, Sanford EJ, Smolka MB, Baskin JM
Structural studies of an androgen receptor complex reveal modes of allosteric regulation.
1. FASEB J - published May 1, 2022
2. Wasmuth EV, Vanden Broeck A, LaClair J, Lawrence KE, Hoover EA, Pappas K, Wang B, Manova-Todorova K, Weintraub ST, Klinge S, Sawyers CL
Global 1 km × 1 km gridded revised real gross domestic product and electricity consumption during 1992-2019 based on calibrated nighttime light data.
1. Sci Data - published May 1, 2022
2. Chen J, Gao M, Cheng S, Hou W, Song M, Liu X, Liu Y
The metaphorical swiss army knife: The multitude and diverse roles of HEAT domains in eukaryotic translation initiation.
1. Nucleic Acids Res - published May 1, 2022
2. Friedrich D, Marintchev A, Arthanari H
Structural Heteropolysaccharide Adhesion to the Corneal Glycocalyx.
1. FASEB J - published May 1, 2022
2. Liu BS, Liao M, Wagner W, Khalil H, Chen Z, Ackermann M, Mentzer SJ
Immune recall improves antibody durability and breadth to SARS-CoV-2 variants.
1. Sci Immunol - published May 1, 2022
2. Chen Y, Tong P, Whiteman N, Moghaddam AS, Zarghami M, Zuiani A, Habibi S, Gautam A, Keerti F, Bi C, Xiao T, Cai Y, Chen B, Neuberg D, Wesemann DR
AMIGOS III: pseudo-torsion angle visualization and motif-based structure comparison of nucleic acids.
1. Bioinformatics - published May 1, 2022
2. Shine M, Zhang C, Pyle AM
Membrane Phosphoinositides Stabilize GPCR-arrestin Complexes and Provide Temporal Control of Complex Assembly and Dynamics.
1. FASEB J - published May 1, 2022
2. Janetzko J, Kise R, Barsi-Rhyne B, Siepe DH, Heydenreich FM, Masureel M, Kawakami K, Garcia KC, von Zastrow M, Inoue A, Kobilka BK
HDX-MS performed on BtuB in E. coli outer membranes delineates the luminal domain's allostery and unfolding upon B12 and TonB binding.
1. Proc Natl Acad Sci U S A - published May 1, 2022
2. Zmyslowski AM, Baxa MC, Gagnon IA, Sosnick TR
Mechanistic basis for the allosteric activation of mitochondrial glutaminase C, a key driver of glutamine metabolism in cancer cells.
1. FASEB J - published May 1, 2022
2. Nguyen TT, Ramachandran S, Hill MJ, Cerione RA
Biocatalytic Carbene Transfer Using Diazirines.
1. J Am Chem Soc - published May 1, 2022
2. Porter NJ, Danelius E, Gonen T, Arnold FH
How do aerobic organisms solve the oxygen sensitivity problem of [4Fe-4S] in radical SAM enzymes?
1. FASEB J - published May 1, 2022
2. Lin H
Mapping Allosteric Sites on Protein Kinases Critical in MAPK Signaling.
1. FASEB J - published May 1, 2022
2. Fera D, Lin S, Naagaard D, Chen H, Finkelstein MT, Glatz G, Hayashi S, Hotan Q, Lau B, LeBlanc J, Li K, Parker Miller E, Ye M, Zaidi H
Loss of Biased Signaling Specificity of the Angiotensin II Type 1 Receptor in Overexpressed Systems.
1. FASEB J - published May 1, 2022
2. Li A, Liu S, Huang R, Ahn S, Lefkowitz RJ
Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.
1. Elife - published May 1, 2022
2. Hosfield DJ, Weber S, Li NS, Suavage M, Joiner CF, Hancock GR, Sullivan EA, Nduwke E, Han R, Cush S, Lainé M, Mader SC, Greene GL, Fanning SW
OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage.
1. Nature - published May 1, 2022
2. Wu XS, He XY, Ipsaro JJ, Huang YH, Preall JB, Ng D, Shue YT, Sage J, Egeblad M, Joshua-Tor L, Vakoc CR
Structure-function analysis for development of peptide inhibitors for a Gram positive quorum sensing system.
1. Mol Microbiol - published May 1, 2022
2. Abdullah IT, Ulijasz AT, Girija UV, Tam S, Andrew P, Hiller NL, Wallis R, Yesilkaya H
A first-in-human Phase I trial of the oral p-STAT3 inhibitor WP1066 in patients with recurrent malignant glioma.
1. CNS Oncol - published May 1, 2022
2. Groot J, Ott M, Wei J, Kassab C, Fang D, Najem H, O'Brien B, Weathers SP, Matsouka CK, Majd NK, Harrison RA, Fuller GN, Huse JT, Long JP, Sawaya R, Rao G, MacDonald TJ, Priebe W, DeCuypere M, Heimberger AB
Phosphinic acid-based inhibitors of tubulin polyglycylation.
1. Chem Commun (Camb) - published May 1, 2022
2. Zhuang Z, Cummings SW, Roll-Mecak A, Tanner ME
Ciliary central apparatus structure reveals mechanisms of microtubule patterning.
1. Nat Struct Mol Biol - published May 1, 2022
2. Gui M, Wang X, Dutcher SK, Brown A, Zhang R
Cryo-EM structure of the human CST-Polα/primase complex in a recruitment state.
1. Nat Struct Mol Biol - published May 1, 2022
2. Cai SW, Zinder JC, Svetlov V, Bush MW, Nudler E, Walz T, de Lange T
A look under the hood of the machine that makes cilia beat.
1. Nat Struct Mol Biol - published May 1, 2022
2. Zehr EA, Roll-Mecak A
Structure of the IL-27 quaternary receptor signaling complex.
1. Elife - published May 1, 2022
2. Caveney NA, Glassman CR, Jude KM, Tsutsumi N, Garcia KC
Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination.
1. JCI Insight - published May 1, 2022
2. Matsui Y, Li L, Prahl M, Cassidy AG, Ozarslan N, Golan Y, Gonzalez VJ, Lin CY, Jigmeddagva U, Chidboy MA, Montano M, Taha TY, Khalid MM, Sreekumar B, Hayashi JM, Chen PY, Kumar GR, Warrier L, Wu AH, Song D, Jegatheesan P, Rai DS, Govindaswami B, Needens JM, Rincon M, Myatt L, Asiodu IV, Flaherman VJ, Afshar Y, Jacoby VL, Murtha AP, Robinson JF, Ott M, Greene WC, Gaw SL
Safety and immunogenicity of an egg-based inactivated Newcastle disease virus vaccine expressing SARS-CoV-2 spike: Interim results of a randomized, placebo-controlled, phase 1/2 trial in Vietnam.
1. Vaccine - published May 1, 2022
2. Duc Dang A, Dinh Vu T, Hai Vu H, Thanh Ta V, Thi Van Pham A, Thi Ngoc Dang M, Van Le B, Huu Duong T, Van Nguyen D, Lawpoolsri S, Chinwangso P, McLellan JS, Hsieh CL, Garcia-Sastre A, Palese P, Sun W, Martinez JL, Gonzalez-Dominguez I, Slamanig S, Manuel Carreño J, Tcheou J, Krammer F, Raskin A, Minh Vu H, Cong Tran T, Mai Nguyen H, Mercer LD, Raghunandan R, Lal M, White JA, Hjorth R, Innis BL, Scharf R
Epitope-focused immunogen design based on the ebolavirus glycoprotein HR2-MPER region.
1. PLoS Pathog - published May 1, 2022
2. Schoeder CT, Gilchuk P, Sangha AK, Ledwitch KV, Malherbe DC, Zhang X, Binshtein E, Williamson LE, Martina CE, Dong J, Armstrong E, Sutton R, Nargi R, Rodriguez J, Kuzmina N, Fiala B, King NP, Bukreyev A, Crowe JE Jr, Meiler J
Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination.
1. Nature - published May 1, 2022
2. Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Gascon R, Tsou CL, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, George AF, Fang X, Maishan M, Matthay M, Morris MK, Wadford D, Hanson C, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna JA, Ott M
Nucleotide-amino acid π-stacking interactions initiate photo cross-linking in RNA-protein complexes.
1. Nat Commun - published May 1, 2022
2. Knörlein A, Sarnowski CP, de Vries T, Stoltz M, Götze M, Aebersold R, Allain FH, Leitner A, Hall J
Broad and ultra-potent cross-clade neutralization of HIV-1 by a vaccine-induced CD4 binding site bovine antibody.
1. Cell Rep Med - published May 1, 2022
2. Heydarchi B, Fong DS, Gao H, Salazar-Quiroz NA, Edwards JM, Gonelli CA, Grimley S, Aktepe TE, Mackenzie C, Wales WJ, van Gils MJ, Cupo A, Rouiller I, Gooley PR, Moore JP, Sanders RW, Montefiori D, Sethi A, Purcell DFJ
Human Monoclonal Antibodies to Escherichia coli Outer Membrane Protein A Porin Domain Cause Aggregation but Do Not Alter In Vivo Bacterial Burdens in a Murine Sepsis Model.
1. Infect Immun - published May 1, 2022
2. Fowler BD, Kose N, Reidy JX, Handal LS, Skaar EP, Crowe JE Jr
Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis.
1. Cell - published May 1, 2022
2. Weiss A, Murdoch CC, Edmonds KA, Jordan MR, Monteith AJ, Perera YR, Rodríguez Nassif AM, Petoletti AM, Beavers WN, Munneke MJ, Drury SL, Krystofiak ES, Thalluri K, Wu H, Kruse ARS, DiMarchi RD, Caprioli RM, Spraggins JM, Chazin WJ, Giedroc DP, Skaar EP
A novel membrane complex is required for docking and regulated exocytosis of lysosome-related organelles in Tetrahymena thermophila.
1. PLoS Genet - published May 1, 2022
2. Kuppannan A, Jiang YY, Maier W, Liu C, Lang CF, Cheng CY, Field MC, Zhao M, Zoltner M, Turkewitz AP
Conversion of a False Virtual Screen Hit into Selective JAK2 JH2 Domain Binders Using Convergent Design Strategies.
1. ACS Med Chem Lett - published May 1, 2022
2. Henry SP, Liosi ME, Ippolito JA, Cutrona KJ, Krimmer SG, Newton AS, Schlessinger J, Jorgensen WL
Structural insights into the assembly and the function of the plant oxidative phosphorylation system.
1. New Phytol - published May 1, 2022
2. Meyer EH, Letts JA, Maldonado M
Repeated exposure to heterologous hepatitis C viruses associates with enhanced neutralizing antibody breadth and potency.
1. J Clin Invest - published May 1, 2022
2. Frumento N, Figueroa A, Wang T, Zahid MN, Wang S, Massaccesi G, Stavrakis G, Crowe JE Jr, Flyak AI, Ji H, Ray SC, Shaw G, Cox AL, Bailey JR
Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation.
1. Nat Commun - published May 1, 2022
2. Bensing BA, Stubbs HE, Agarwal R, Yamakawa I, Luong K, Solakyildirim K, Yu H, Hadadianpour A, Castro MA, Fialkowski KP, Morrison KM, Wawrzak Z, Chen X, Lebrilla CB, Baudry J, Smith JC, Sullam PM, Iverson TM
Discovery proteomics analysis determines that driver oncogenes suppress antiviral defense pathways through reduction in interferon-b autocrine stimulation.
1. Mol Cell Proteomics - published May 1, 2022
2. Solomon PE, Kirkemo LL, Wilson GM, Leung KK, Almond MH, Sayles LC, Sweet-Cordero EA, Rosenberg OS, Coon JJ, Wells JA
Spn1 and its dynamic interactions with Spt6, histones and nucleosomes.
1. J Mol Biol - published May 1, 2022
2. Li S, Edwards G, Radebaugh CA, Luger K, A Stargell L
Modeling of protein conformational changes with Rosetta guided by limited experimental data.
1. Structure - published May 1, 2022
2. Sala D, Del Alamo D, Mchaourab HS, Meiler J
Principles and practical applications of structure-based vaccine design.
1. Curr Opin Immunol - published May 1, 2022
2. Byrne PO, McLellan JS
Physiology and biophysics of outer hair cells: The cells of Dallos.
1. Hear Res - published May 1, 2022
2. Santos-Sacchi J, Navaratnam D
Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC.
1. Nat Commun - published May 1, 2022
2. Lam AKM, Rutz S, Dutzler R
Structure-function analysis of cysteine residues in the plasmodium falciparum chitinase, PfCHT1.
1. Protein Sci - published May 1, 2022
2. Kaur H, Garber L, Murphy JW, Vinetz JM
The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation.
1. Proc Natl Acad Sci U S A - published May 1, 2022
2. Wieland M, Holm M, Rundlet EJ, Morici M, Koller TO, Maviza TP, Pogorevc D, Osterman IA, Müller R, Blanchard SC, Wilson DN
Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women.
1. Nat Microbiol - published May 1, 2022
2. Worby CJ, Schreiber HL 4th, Straub TJ, van Dijk LR, Bronson RA, Olson BS, Pinkner JS, Obernuefemann CLP, Muñoz VL, Paharik AE, Azimzadeh PN, Walker BJ, Desjardins CA, Chou WC, Bergeron K, Chapman SB, Klim A, Manson AL, Hannan TJ, Hooton TM, Kau AL, Lai HH, Dodson KW, Hultgren SJ, Earl AM
A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane.
1. Proc Natl Acad Sci U S A - published May 1, 2022
2. Lin CW, Nocka LM, Stinger BL, DeGrandchamp JB, Lew LJN, Alvarez S, Phan HT, Kondo Y, Kuriyan J, Groves JT
Rhinoviruses usurp STING for replication.
1. Nat Microbiol - published May 1, 2022
2. Luteijn RD, van Kuppeveld FJM
Stickland metabolism in the gut.
1. Nat Microbiol - published May 1, 2022
2. Little AS, Light SH
C₃-Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity.
1. ACS Chem Biol - published May 1, 2022
2. Sun J, Zhao G, Bylund T, Lee M, Adibhatla S, Kwong PD, Chuang GY, Rawi R, Bewley CA
Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of pho1 Gene Expression.
1. mBio - published May 1, 2022
2. Benjamin B, Garg A, Jork N, Jessen HJ, Schwer B, Shuman S
Human Metapneumovirus Phosphoprotein Independently Drives Phase Separation and Recruits Nucleoprotein to Liquid-Like Bodies.
1. mBio - published May 1, 2022
2. Boggs KB, Edmonds K, Cifuentes-Munoz N, El Najjar F, Ossandón C, Roe M, Wu C, Moncman CL, Creamer TP, Amarasinghe GK, Leung DW, Dutch RE
Antibodies induced by ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.1.
1. Sci Immunol - published May 1, 2022
2. Windsor IW, Tong P, Lavidor O, Sanjari Moghaddam A, McKay LGA, Gautam A, Chen Y, MacDonald EA, Yoo DK, Griffiths A, Wesemann DR, Harrison SC
Evolution of Enterococcus faecium in Response to a Combination of Daptomycin and Fosfomycin Reveals Distinct and Diverse Adaptive Strategies.
1. Antimicrob Agents Chemother - published May 1, 2022
2. Supandy A, Mehta HH, Tran TT, Miller WR, Zhang R, Xu L, Arias CA, Shamoo Y
Structure of a TRAPPII-Rab11 activation intermediate reveals GTPase substrate selection mechanisms.
1. Sci Adv - published May 1, 2022
2. Bagde SR, Fromme JC
The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development.
1. Development - published May 1, 2022
2. Wang Y, Venkatesh A, Xu J, Xu M, Williams J, Smallwood PM, James A, Nathans J
Filling in the GAPs- Mapping the Spatiotemporal Kinetics of Arf1 and its Regulators.
1. FASEB J - published May 1, 2022
2. Manzer K, Fromme JC
IGF2BP2 Promotes Cancer Progression by Degrading the RNA Transcript Encoding a v-ATPase Subunit.
1. FASEB J - published May 1, 2022
2. Wang F, Latifkar A, Mullmann J, Panizza E, Fernandez I, Ling L, Miller A, Fischbach C, Weiss R, Lin H, Cerione R, Antonyak M
Mechanism of Activation of SgrAI via Enzyme Filamentation and Mechanism of DNA Sequence Specificity Expansion.
1. FASEB J - published May 1, 2022
2. Horton N, Ghadirian N, Shan Z, Lyumkis D
Visualizing the Gas Channel of a Monofunctional Carbon Monoxide Dehydrogenase.
1. FASEB J - published May 1, 2022
2. Biester A, Dementin S, Drennan CL
Analysis of the interactions between the HIV-1 Spike and the F7-22 "cooperating" antibody.
1. FASEB J - published May 1, 2022
2. Parker Miller E, Fera D
Investigating the Interaction Interface between MEK and ERK Kinase.
1. FASEB J - published May 1, 2022
2. Lin S, Naagaard MD, Pham T, Fera D
Structurally investigating a niche pathway for chemical reversal of proline hydroxylation in the pathogen Clostridioides difficile.
1. FASEB J - published May 1, 2022
2. Backman LRF, Huang YY, Andorfer MC, Gold B, Raines RT, Balskus EP, Drennan CL
Auto-inhibitory interactions of Sec7, master regulator of the Golgi complex.
1. FASEB J - published May 1, 2022
2. Brownfield BA, Fromme JC
Biochemical analysis of human ERK2 mutants reveals important residues in MEK1-ERK2 binding and phosphorylation.
1. FASEB J - published May 1, 2022
2. Ye M, Hotan Q, Glatz G, Finkelstein MT, Hayashi S, Miller EP, Lau B, Li K, Chen H, LeBlanc J, Zaidi H, Fera D
Conserved structural elements specialize ATAD1 as a membrane protein extraction machine.
1. Elife - published May 1, 2022
2. Wang L, Toutkoushian H, Belyy V, Kokontis CY, Walter P
Structural basis for the activation of Arf1 at the Golgi complex by its GEF Gea2.
1. FASEB J - published May 1, 2022
2. Muccini A, Fromme JC
Bioinformatics and 3D Structural Analysis of the Coronavirus Main Protease Active Site Diversity.
1. FASEB J - published May 1, 2022
2. Wu Wu A, Lubin JH, Olivas C, Zardecki C, Balogun M, Bacorn ML, Khare SD, Burley SK
Looking lively: emerging principles of pseudokinase signaling.
1. Trends Biochem Sci - published May 1, 2022
2. Sheetz JB, Lemmon MA
Characterization of the DH475 cooperating antibody and its interaction with the HIV-1 spike.
1. FASEB J - published May 1, 2022
2. Finkelstein MT, Erdman MC, Fera D
Correlated motions in enzymes.
1. FASEB J - published May 1, 2022
2. Ando N, Meisburger SP, Case DA
Structural Investigation of Allosteric Regulation in Class III Ribonucleotide Reductases.
1. FASEB J - published May 1, 2022
2. Andree GA, Levitz TS, Funk MA, Dawson CD, Drennan CL
Some assembly required: structural and mechanistic studies of histone chaperones, nucleosome assembly factors and ATP dependent chromatin remodelers.
1. FASEB J - published May 1, 2022
2. Luger K, Zhou K, Markert J, Liu Y
Molecular Basis for Membrane Binding and Lipolysis Activation by ABHD5.
1. FASEB J - published May 1, 2022
2. Wu L, Sokolova V, Tan D, Airola M
Structure-Based Strategies for Rieske Oxygenase Catalysis.
1. FASEB J - published May 1, 2022
2. Bridwell-Rabb J, Liu J, Tian J, Dill Z
First-in-class Deubiquitylase Inhibitors Reveal New Enzyme Conformations.
1. FASEB J - published May 1, 2022
2. Chandler F, Walden M, Reddy PAN, Cassel J, Bell L, Campbell L, Foglizzo M, Sicheri F, Salvino JM, Greenberg RA, Zeqiraj E
Structure Insights into Biased Signaling of kappa Opioid Receptor.
1. FASEB J - published May 1, 2022
2. El Daibani A, Paggi J, Kim K, Laloudakis Y, Popov P, Bernhard S, Olsen RH, Diberto J, Katritch V, Wunsch B, Dror R, Che T
Molecular-scale structure of a high-curvature membrane.
1. FASEB J - published May 1, 2022
2. Frost A, Moss FR 3rd, Lincoff J, Tucker M, Mohammed A, Grabe M
Structural Investigation of AlsA, a Radical S-adenosylmethionine Enzyme Involved in the Biosynthesis of the Oxetane-containing Herbicide Albucidin.
1. FASEB J - published May 1, 2022
2. Avalos D, Fan PH, Geng Y, Liu HW, Drennan CL