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80 Member Publications for May

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DNA recognition by an RNA-guided bacterial Argonaute.
1. PLoS One - published May 19, 2017
2. Doxzen KW, Doudna JA
SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands.
1. PLoS One - published May 17, 2017
2. Huber S, Casagrande F, Hug MN, Wang L, Heine P, Kummer L, Plückthun A, Hennig M
Relationship between recombinant protein expression and host metabolome as determined by two-dimensional NMR spectroscopy.
1. PLoS One - published May 10, 2017
2. Chae YK, Kim SH, Markley JL
Halogen bonding in medicinal chemistry: from observation to prediction.
1. Future Med Chem - published May 9, 2017
2. Ho PS
Functional mapping of yeast genomes by saturated transposition.
1. Elife - published May 8, 2017
2. Michel AH, Hatakeyama R, Kimmig P, Arter M, Peter M, Matos J, De Virgilio C, Kornmann B
Atypical interactions of integrin αVβ8 with pro-TGF-β1.
1. Proc Natl Acad Sci U S A - published May 8, 2017
2. Wang J, Dong X, Zhao B, Li J, Lu C, Springer TA
Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes.
1. Nat Chem Biol - published May 8, 2017
2. Park J, Gasparrini AJ, Reck MR, Symister CT, Elliott JL, Vogel JP, Wencewicz TA, Dantas G, Tolia NH
Biomolecular NMR: Past and future.
1. Arch Biochem Biophys - published May 8, 2017
2. Markley JL, Westler WM
Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion.
1. Elife - published May 6, 2017
2. Sitarska E, Xu J, Park S, Liu X, Quade B, Stepien K, Sugita K, Brautigam CA, Sugita S, Rizo J
Amphoteric Borylketenimines: Versatile Intermediates in the Synthesis of Borylated Heterocycles.
1. Chemistry - published May 5, 2017
2. Yudin AK, Kaldas SJ, O'Keefe KTV, Rodrigo MS
The molecular mechanism of the type IVa pilus motors.
1. Nat Commun - published May 5, 2017
2. McCallum M, Tammam S, Khan A, Burrows LL, Howell PL
MYB fusions and CD markers as tools for authentication and purification of cancer stem cells from salivary adenoid cystic carcinoma.
1. Stem Cell Res - published May 5, 2017
2. Panaccione A, Zhang Y, Ryan M, Moskaluk CA, Anderson KS, Yarbrough WG, Ivanov SV
Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico.
1. Cell - published May 4, 2017
2. Robbiani DF, Bozzacco L, Keeffe JR, Khouri R, Olsen PC, Gazumyan A, Schaefer-Babajew D, Avila-Rios S, Nogueira L, Patel R, Azzopardi SA, Uhl LFK, Saeed M, Sevilla-Reyes EE, Agudelo M, Yao KH, Golijanin J, Gristick HB, Lee YE, Hurley A, Caskey M, Pai J, Oliveira T, Wunder EA Jr, Sacramento G, Nery N Jr, Orge C, Costa F, Reis MG, Thomas NM, Eisenreich T, Weinberger DM, de Almeida ARP, West AP Jr, Rice CM, Bjorkman PJ, Reyes-Teran G, Ko AI, MacDonald MR, Nussenzweig MC
Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex.
1. Cell - published May 4, 2017
2. Bodnar NO, Rapoport TA
Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1.
1. Mol Cell - published May 4, 2017
2. Bednar J, Garcia-Saez I, Boopathi R, Cutter AR, Papai G, Reymer A, Syed SH, Lone IN, Tonchev O, Crucifix C, Menoni H, Papin C, Skoufias DA, Kurumizaka H, Lavery R, Hamiche A, Hayes JJ, Schultz P, Angelov D, Petosa C, Dimitrov S
RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes.
1. Mol Cell - published May 4, 2017
2. East-Seletsky A, O'Connell MR, Burstein D, Knott GJ, Doudna JA
Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.
1. Nature - published May 3, 2017
2. Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, Kuo CJ
ALDH1A3 in CSCs.
1. Aging (Albany NY) - published May 3, 2017
2. Sullivan KE, Cerione RA, Wilson KF
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling.
1. Nature - published May 3, 2017
2. Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ, Garcia KC
Single-protein detection in crowded molecular environments in cryo-EM images.
1. Elife - published May 3, 2017
2. Rickgauer JP, Grigorieff N, Denk W
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes.
1. Neuron - published May 3, 2017
2. Twomey EC, Yelshanskaya MV, Grassucci RA, Frank J, Sobolevsky AI
Antibody-induced internalization of the human respiratory syncytial virus fusion protein.
1. J Virol - published May 3, 2017
2. Leemans A, De Schryver M, Van der Gucht W, Heykers A, Pintelon I, Hotard AL, Moore ML, Melero JA, McLellan JS, Graham BS, Broadbent L, Power UF, Caljon G, Cos P, Maes L, Delputte P
A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants.
1. Sci Transl Med - published May 3, 2017
2. Zhu Q, McLellan JS, Kallewaard NL, Ulbrandt ND, Palaszynski S, Zhang J, Moldt B, Khan A, Svabek C, McAuliffe JM, Wrapp D, Patel NK, Cook KE, Richter BWM, Ryan PC, Yuan AQ, Suzich JA
Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.
1. J Biol Chem - published May 2, 2017
2. Zhang J, Johnson JL, He J, Napolitano G, Ramadass M, Rocca C, Kiosses WB, Bucci C, Xin Q, Gavathiotis E, Cuervo AM, Cherqui S, Catz SD
Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6.
1. Sci Rep - published May 2, 2017
2. Brüser A, Zimmermann A, Crews BC, Sliwoski G, Meiler J, König GM, Kostenis E, Lede V, Marnett LJ, Schöneberg T
Discovery of a Prefusion RSV F-Specific Monoclonal Antibody that Provides Greater in vivo Protection than the Murine Precursor of Palivizumab.
1. J Virol - published May 2, 2017
2. Zhao M, Zheng ZZ, Chen M, Modjarrad K, Zhang W, Zhan LT, Cao JL, Sun YP, McLellan JS, Graham BS, Xia NS
Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells.
1. Sci Signal - published May 2, 2017
2. Severson E, Arnett KL, Wang H, Zang C, Taing L, Liu H, Pear WS, Shirley Liu X, Blacklow SC, Aster JC
Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor.
1. J Med Chem - published May 2, 2017
2. Zhao Y, Bai L, Liu L, McEachern D, Stuckey JA, Meagher JL, Yang CY, Ran X, Zhou B, Hu Y, Li X, Wen B, Zhao T, Li S, Sun D, Wang S
The COMPLEXity in herpesvirus entry.
1. Curr Opin Virol - published May 2, 2017
2. Sathiyamoorthy K, Chen J, Longnecker R, Jardetzky TS
Ensemble cryo-EM elucidates the mechanism of translation fidelity.
1. Nature - published May 2, 2017
2. Loveland AB, Demo G, Grigorieff N, Korostelev AA
The Individual and Population Genetics of Antibody Immunity.
1. Trends Immunol - published May 2, 2017
2. Watson CT, Glanville J, Marasco WA
A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases.
1. Elife - published May 2, 2017
2. Bradshaw N, Levdikov VM, Zimanyi CM, Gaudet R, Wilkinson AJ, Losick R
Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions.
1. PLoS Negl Trop Dis - published May 2, 2017
2. Sheikh A, Rashu R, Begum YA, Kuhlman FM, Ciorba MA, Hultgren SJ, Qadri F, Fleckenstein JM
pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase.
1. Nat Commun - published May 2, 2017
2. An J, Ponthier CM, Sack R, Seebacher J, Stadler MB, Donovan KA, Fischer ES
Induced Fit Is a Special Case of Conformational Selection.
1. Biochemistry - published May 2, 2017
2. Chakraborty P, Di Cera E
Composition-dependent electronic energy relaxation dynamics of metal domains as revealed by bimetallic Au144-xAgx(SC8H9)60 monolayer-protected clusters.
1. Phys Chem Chem Phys - published May 2, 2017
2. Zheng H, Tofanelli MA, Ackerson CJ, Knappenberger KL
Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus.
1. Nat Commun - published May 2, 2017
2. Kotecha A, Wang Q, Dong X, Ilca SL, Ondiviela M, Zihe R, Seago J, Charleston B, Fry EE, Abrescia NGA, Springer TA, Huiskonen JT, Stuart DI
Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
1. Proc Natl Acad Sci U S A - published May 2, 2017
2. Shi Y, Hellinga HW, Beese LS
Molecular basis for PrimPol recruitment to replication forks by RPA.
1. Nat Commun - published May 2, 2017
2. Guilliam TA, Brissett NC, Ehlinger A, Keen BA, Kolesar P, Taylor EM, Bailey LJ, Lindsay HD, Chazin WJ, Doherty AJ
Unique identifiers for small molecules enable rigorous labeling of their atoms.
1. Sci Data - published May 2, 2017
2. Dashti H, Westler WM, Markley JL, Eghbalnia HR
Converting lymphoma cells into potent antigen-presenting cells for interferon-induced tumor regression.
1. Cancer Immunol Res - published May 2, 2017
2. Liao J, Luan Y, Ren Z, Liu X, Xue D, Xu H, Sun Z, Yang K, Peng H, Fu YX
Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.
1. Proc Natl Acad Sci U S A - published May 2, 2017
2. Huber FM, Greenblatt SM, Davenport AM, Martinez C, Xu Y, Vu LP, Nimer SD, Hoelz A
Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.
1. Nature - published May 2, 2017
2. Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G
Functional Analysis of Human Cytochrome P450 21A2 Variants Involved in Congenital Adrenal Hyperplasia.
1. J Biol Chem - published May 2, 2017
2. Wang C, Pallan PS, Zhang W, Lei L, Yoshimoto FK, Waterman MR, Egli M, Guengerich FP
A cryo-EM-based model of phosphorylation- and FKBP12.6-mediated allosterism of the cardiac ryanodine receptor.
1. Sci Signal - published May 2, 2017
2. Dhindwal S, Lobo J, Cabra V, Santiago DJ, Nayak AR, Dryden K, Samsó M
Observation of CH⋅⋅⋅π Interactions between Methyl and Carbonyl Groups in Proteins.
1. Angew Chem Int Ed Engl - published May 2, 2017
2. Perras FA, Marion D, Boisbouvier J, Bryce DL, Plevin MJ
Improved prefusion stability, optimized codon-usage, and augmented virion packaging enhance the immunogenicity of respiratory syncytial virus (RSV) fusion protein in a vectored vaccine candidate.
1. J Virol - published May 2, 2017
2. Liang B, Ngwuta JO, Surman S, Kabatova B, Liu X, Lingemann M, Liu X, Yang L, Herbert R, Swerczek J, Chen M, Moin SM, Kumar A, McLellan JS, Kwong PD, Graham BS, Collins PL, Munir S
An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors.
1. Nat Commun - published May 1, 2017
2. Scanlon DP, Bah A, Krzeminski M, Zhang W, Leduc-Pessah HL, Dong YN, Forman-Kay JD, Salter MW
Crystal structure of the new investigational drug candidate VT-1598 in complex with Aspergillus fumigatus sterol 14α-demethylase provides insights into its broad-spectrum antifungal activity.
1. Antimicrob Agents Chemother - published May 1, 2017
2. Hargrove TY, Garvey EP, Hoekstra WJ, Yates CM, Wawrzak Z, Rachakonda G, Villalta F, Lepesheva GI
Molecular Simulation and Biochemical Studies Support an Elevator-Type Transport Mechanism in EIIC.
1. Biophys J - published May 1, 2017
2. Lee J, Ren Z, Zhou M, Im W
Mammalian O-mannosylation of Cadherins and Plexins is Independent of Protein O-mannosyltransferase 1 and 2.
1. J Biol Chem - published May 1, 2017
2. Larsen ISB, Narimatsu Y, Joshi HJ, Yang Z, Harrison OJ, Brasch J, Shapiro L, Honig B, Vakhrushev SY, Clausen H, Halim A
Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop.
1. Immunity - published May 1, 2017
2. Cale EM, Gorman J, Radakovich NA, Crooks ET, Osawa K, Tong T, Li J, Nagarajan R, Ozorowski G, Ambrozak DR, Asokan M, Bailer RT, Bennici AK, Chen X, Doria-Rose NA, Druz A, Feng Y, Joyce MG, Louder MK, O'Dell S, Oliver C, Pancera M, Connors M, Hope TJ, Kepler TB, Wyatt RT, Ward AB, Georgiev IS, Kwong PD, Mascola JR, Binley JM
The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands.
1. Cell Rep - published May 1, 2017
2. Hilton HG, McMurtrey CP, Han AS, Djaoud Z, Guethlein LA, Blokhuis JH, Pugh JL, Goyos A, Horowitz A, Buchli R, Jackson KW, Bardet W, Bushnell DA, Robinson PJ, Mendoza JL, Birnbaum ME, Nielsen M, Garcia KC, Hildebrand WH, Parham P
Signal Transduction: Notch catches a Jagged edge.
1. Nat Chem Biol - published May 1, 2017
2. Blacklow SC
Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.
1. Nat Commun - published May 1, 2017
2. de Opakua AI, Parag-Sharma K, DiGiacomo V, Merino N, Leyme A, Marivin A, Villate M, Nguyen LT, de la Cruz-Morcillo MA, Blanco-Canosa JB, Ramachandran S, Baillie GS, Cerione RA, Blanco FJ, Garcia-Marcos M
How HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design.
1. Curr Opin HIV AIDS - published May 1, 2017
2. Pancera M, Changela A, Kwong PD
Adaptation of HIV-1 to cells with low expression of the CCR5 coreceptor.
1. Virology - published May 1, 2017
2. Espy N, Pacheco B, Sodroski J
Selective BET bromodomain inhibition as an antifungal therapeutic strategy.
1. Nat Commun - published May 1, 2017
2. Mietton F, Ferri E, Champleboux M, Zala N, Maubon D, Zhou Y, Harbut M, Spittler D, Garnaud C, Courçon M, Chauvel M, d'Enfert C, Kashemirov BA, Hull M, Cornet M, McKenna CE, Govin J, Petosa C
Electron crystallography reveals that substrate release from the PTS IIC glucose transporter is coupled to a subtle conformational change.
1. J Struct Biol - published May 1, 2017
2. Kalbermatter D, Chiu PL, Jeckelmann JM, Ucurum Z, Walz T, Fotiadis D
Molecular assembly of rhodopsin with G protein-coupled receptor kinases.
1. Cell Res - published May 1, 2017
2. He Y, Gao X, Goswami D, Hou L, Pal K, Yin Y, Zhao G, Ernst OP, Griffin P, Melcher K, Xu HE
Pseudomonas aeruginosa Exolysin promotes bacterial growth in lungs, alveolar damage and bacterial dissemination.
1. Sci Rep - published May 1, 2017
2. Bouillot S, Munro P, Gallet B, Reboud E, Cretin F, Golovkine G, Schoehn G, Attrée I, Lemichez E, Huber P
Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome.
1. Nat Commun - published May 1, 2017
2. Jomaa A, Fu YH, Boehringer D, Leibundgut M, Shan SO, Ban N
ATP controls the crowd.
1. Science - published May 1, 2017
2. Rice AM, Rosen MK
The group II intron maturase: a reverse transcriptase and splicing factor go hand in hand.
1. Curr Opin Struct Biol - published May 1, 2017
2. Zhao C, Pyle AM
Induction of a Tier-1-like Phenotype in Diverse Tier-2 Isolates by Agents that Guide HIV-1 Env to Perturbation-sensitive, Non-native States.
1. J Virol - published May 1, 2017
2. Johnson J, Zhai Y, Salimi H, Espy N, Eichelberger N, DeLeon O, O'Malley Y, Courter J, Smith AB 3rd, Madani N, Sodroski J, Haim H
Neutron and Atomic Resolution X-ray Structures of a Lytic Polysaccharide Monooxygenase Reveal Copper-Mediated Dioxygen Binding and Evidence for N-Terminal Deprotonation.
1. Biochemistry - published May 1, 2017
2. Bacik JP, Mekasha S, Forsberg Z, Kovalevsky AY, Vaaje-Kolstad G, Eijsink VGH, Nix JC, Coates L, Cuneo MJ, Unkefer CJ, Chen JC
Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers.
1. Elife - published May 1, 2017
2. Moraga I, Spangler JB, Mendoza JL, Gakovic M, Wehrman TS, Krutzik P, Garcia KC
Implementation of Objective PASC-Derived Taxon Demarcation Criteria for Official Classification of Filoviruses.
1. Viruses - published May 1, 2017
2. Bào Y, Amarasinghe GK, Basler CF, Bavari S, Bukreyev A, Chandran K, Dolnik O, Dye JM, Ebihara H, Formenty P, Hewson R, Kobinger GP, Leroy EM, Mühlberger E, Netesov SV, Patterson JL, Paweska JT, Smither SJ, Takada A, Towner JS, Volchkov VE, Wahl-Jensen V, Kuhn JH
Probing the Effects of Gating on the Ion Occupancy of the K+ Channel Selectivity Filter Using Two-Dimensional Infrared Spectroscopy.
1. J Am Chem Soc - published May 1, 2017
2. Kratochvil HT, Maj M, Matulef K, Annen AW, Ostmeyer J, Perozo E, Roux B, Valiyaveetil FI, Zanni MT
Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer.
1. Nature - published May 1, 2017
2. Lim JS, Ibaseta A, Fischer MM, Cancilla B, O'Young G, Cristea S, Luca VC, Yang D, Jahchan NS, Hamard C, Antoine M, Wislez M, Kong C, Cain J, Liu YW, Kapoun AM, Garcia KC, Hoey T, Murriel CL, Sage J
Fundamental trade-offs between information flow in single cells and cellular populations.
1. Proc Natl Acad Sci U S A - published May 1, 2017
2. Suderman R, Bachman JA, Smith A, Sorger PK, Deeds EJ
Structural basis of cooperativity in kinesin revealed by 3D reconstruction of a two-head-bound state on microtubules.
1. Elife - published May 1, 2017
2. Liu D, Liu X, Shang Z, Sindelar CV
The mitochondrial respiratory chain is essential for haematopoietic stem cell function.
1. Nat Cell Biol - published May 1, 2017
2. Ansó E, Weinberg SE, Diebold LP, Thompson BJ, Malinge S, Schumacker PT, Liu X, Zhang Y, Shao Z, Steadman M, Marsh KM, Xu J, Crispino JD, Chandel NS
Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.
1. Nat Cell Biol - published May 1, 2017
2. Liu X, Zhang Y, Ni M, Cao H, Signer RAJ, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, Xu J
Structural insights into reptarenavirus cap-snatching machinery.
1. PLoS Pathog - published May 1, 2017
2. Rosenthal M, Gogrefe N, Vogel D, Reguera J, Rauschenberger B, Cusack S, Günther S, Reindl S
CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface.
1. J Mol Biol - published May 1, 2017
2. Liu Y, Pan J, Jenni S, Raymond DD, Caradonna T, Do KT, Schmidt AG, Harrison SC, Grigorieff N
Structural and Biochemical Insights into Dimethylsulfoniopropionate Cleavage by Cofactor-bound DddK from the Prolific Marine Bacterium Pelagibacter.
1. Biochemistry - published May 1, 2017
2. Schnicker NJ, De Silva SM, Todd JD, Dey M
Direct observation of structure and dynamics during phase separation of an elastomeric protein.
1. Proc Natl Acad Sci U S A - published May 1, 2017
2. Reichheld SE, Muiznieks LD, Keeley FW, Sharpe S
Functional RNA structures throughout the Hepatitis C Virus genome.
1. Curr Opin Virol - published May 1, 2017
2. Adams RL, Pirakitikulr N, Pyle AM
Response Heterogeneity of EGFR and HER2 Exon 20 Insertions to Covalent EGFR and HER2 Inhibitors.
1. Cancer Res - published May 1, 2017
2. Kosaka T, Tanizaki J, Paranal RM, Endoh H, Lydon C, Capelletti M, Repellin CE, Choi J, Ogino A, Calles A, Ercan D, Redig AJ, Bahcall M, Oxnard GR, Eck MJ, Jänne PA