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56 Member Publications for October

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Clamping Pol ε to the leading strand.
1. Nat Struct Mol Biol - published October 2, 2024
2. Singh N, Johansson E
Discovery of Truncated Cyclic Peptides Targeting an Induced-Fit Pocket on PCSK9.
1. ChemMedChem - published October 2, 2024
2. Grosche P, Flyer AN, Gattlen R, Xu M, Golosov AA, Vera V, Pickett S, Brousseau ME, Chopra R, Clairmont KB, Koch A, Liu E, Reid P, Perry L, Yang L, Yang Q, Monovich LG
Reconstitution of Rab11-FIP4 Expression Rescues Cellular Homeostasis in Cystinosis.
1. Mol Cell Biol - published October 2, 2024
2. Rahman F, Johnson JL, Ait Kbaich M, Meneses-Salas E, Shukla A, Chen D, Kiosses WB, Gavathiotis E, Cuervo AM, Cherqui S, Catz SD
DiffModeler: large macromolecular structure modeling for cryo-EM maps using a diffusion model.
1. Nat Methods - published October 2, 2024
2. Wang X, Zhu H, Terashi G, Taluja M, Kihara D
Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling.
1. Nat Commun - published October 2, 2024
2. Zhang R, Jagessar KL, Brownd M, Polasa A, Stein RA, Moradi M, Karakas E, Mchaourab HS
Conformation matters: siRNAs with antisense strands with 5'-(E)-vinyl-phosphonate-α-L-LNA elicit stronger RNAi-mediated gene silencing than those with 5'-(E)-vinyl-phosphonate-LNA.
1. Chem Commun (Camb) - published October 2, 2024
2. Datta D, Kumar P, Mandal S, Krampert M, Egli M, Hrdlicka PJ, Manoharan M
Dramatic changes in mitochondrial subcellular location and morphology accompany activation of the CO(2) concentrating mechanism.
1. Proc Natl Acad Sci U S A - published October 2, 2024
2. Findinier J, Joubert LM, Fakhimi N, Schmid MF, Malkovskiy AV, Chiu W, Burlacot A, Grossman AR
An interpretable deep learning framework identifies proteomic drivers of Alzheimer's disease.
1. Front Cell Dev Biol - published October 2, 2024
2. Panizza E, Cerione RA
Identification, characterization, and structure of a tRNA splicing enzyme RNA 5'-OH kinase from the pathogenic fungi Mucorales.
1. RNA - published October 2, 2024
2. Ghosh S, Wimberly-Gard G, Jacewicz A, Schwer B, Shuman S
Quinoline-based compounds can inhibit diverse enzymes that act on DNA.
1. Cell Chem Biol - published October 1, 2024
2. Zhou J, Chen Q, Ren R, Yang J, Liu B, Horton JR, Chang C, Li C, Maksoud L, Yang Y, Rotili D, Jain AK, Zhang X, Blumenthal RM, Chen T, Gao Y, Valente S, Mai A, Cheng X
Nanobodies: from high-throughput identification to therapeutic development.
1. Mol Cell Proteomics - published October 1, 2024
2. Fridy PC, Rout MP, Ketaren NE
Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase.
1. iScience - published October 1, 2024
2. Gedeon A, Yab E, Dinut A, Sadowski E, Capton E, Dreneau A, Petit J, Gioia B, Piveteau C, Djaout K, Lecat E, Wehenkel AM, Gubellini F, Mechaly A, Alzari PM, Deprez B, Baulard A, Aubry A, Willand N, Petrella S
Determination of Protein-Ligand Binding Affinities by Thermal Shift Assay.
1. ACS Pharmacol Transl Sci - published October 1, 2024
2. Khan MF, Rahman MM, Xin Y, Mustafa A, Smith BJ, Ottemann KM, Roujeinikova A
Structural insights into the DNA-binding mechanism of BCL11A: The integral role of ZnF6.
1. Structure - published October 1, 2024
2. Viennet T, Yin M, Jayaraj A, Kim W, Sun ZJ, Fujiwara Y, Zhang K, Seruggia D, Seo HS, Dhe-Paganon S, Orkin SH, Arthanari H
Comprehensive functional evaluation of head and neck squamous cell carcinoma with BH3-profiling demonstrates apoptotic competency and therapeutic efficacy of BH3-mimetics.
1. Oral Oncol - published October 1, 2024
2. Li D, Lopez A, Shrivastava N, Chan W, Thomas C, Burk R, Segall J, Augustine S, Rosenblatt G, Mehta V, Schiff BA, Smith RV, Prystowsky MB, Schlecht NF, Guha C, Gavathiotis E, Ow TJ
Phosphorylation regulates the chromatin remodeler SMARCAD1 in nucleosome binding, ATP hydrolysis, and histone exchange.
1. J Biol Chem - published October 1, 2024
2. Aboulache BL, Hoitsma NM, Luger K
Qingshen granules inhibits dendritic cell glycolipid metabolism to alleviate renal fibrosis via PI3K-AKT-mTOR pathway.
1. Phytomedicine - published October 1, 2024
2. Zhou WJ, Liang W, Hu MX, Ma YK, Yu S, Jin C, Li JQ, Wang C, Wang CZ, Gong P, Wu QQ, Wu CG, Wang YP, Liu TT
The homeodomain regulates stable DNA binding of prostate cancer target ONECUT2.
1. Nat Commun - published October 1, 2024
2. Chatterjee A, Gallent B, Katiki M, Qian C, Harter MR, Silletti S, Komives EA, Freeman MR, Murali R
A conserved fertilization complex bridges sperm and egg in vertebrates.
1. Cell - published October 1, 2024
2. Deneke VE, Blaha A, Lu Y, Suwita JP, Draper JM, Phan CS, Panser K, Schleiffer A, Jacob L, Humer T, Stejskal K, Krssakova G, Roitinger E, Handler D, Kamoshita M, Vance TDR, Wang X, Surm JM, Moran Y, Lee JE, Ikawa M, Pauli A
A flagellar accessory protein links chemotaxis to surface sensing.
1. J Bacteriol - published October 1, 2024
2. Salemi RI, Cruz AK, Hershey DM
An ILC2-chitinase circuit restores lung homeostasis after epithelial injury.
1. Sci Immunol - published October 1, 2024
2. Jung H, Kim DH, Díaz RE, White JM, Rucknagel S, Mosby L, Wang Y, Reddy S, Winkler ES, Hassan AO, Ying B, Diamond MS, Locksley RM, Fraser JS, Van Dyken SJ
MPXV Infection Stimulates a More Robust and Durable Neutralizing Antibody Response Compared to MVA-BN Vaccination.
1. J Infect Dis - published October 1, 2024
2. Selverian CN, Monticelli SR, Jaleta YM, Lasso G, DeMouth ME, Meola A, Berrigan J, Batchelor TG, Battini L, Guardado-Calvo P, Herbert AS, Chandran K, Meyerowitz E, Miller EH
SARS-CoV-2 ferritin nanoparticle vaccines produce hyperimmune equine sera with broad sarbecovirus activity.
1. iScience - published October 1, 2024
2. Martinez EJ, Chang WC, Chen WH, Hajduczki A, Thomas PV, Jensen JL, Choe M, Sankhala RS, Peterson CE, Rees PA, Kimner J, Soman S, Kuklis C, Mendez-Rivera L, Dussupt V, King J, Corbett C, Mayer SV, Fernandes A, Murzello K, Cookenham T, Hvizdos J, Kummer L, Hart T, Lanzer K, Gambacurta J, Reagan M, Duso D, Vasan S, Collins ND, Michael NL, Krebs SJ, Gromowski GD, Modjarrad K, Kaundinya J, Joyce MG
Notch induces transcription by stimulating release of paused RNA polymerase II.
1. Genes Dev - published October 1, 2024
2. Rogers JM, Mimoso CA, Martin BJE, Martin AP, Aster JC, Adelman K, Blacklow SC
Mechanism of bacterial predation via ixotrophy.
1. Science - published October 1, 2024
2. Lien YW, Amendola D, Lee KS, Bartlau N, Xu J, Furusawa G, Polz MF, Stocker R, Weiss GL, Pilhofer M
Chikungunya virus E2 B domain nanoparticle immunogen elicits homotypic neutralizing antibody in mice.
1. Vaccine - published October 1, 2024
2. Tong K, Hernandez EM, Basore K, Fremont DH, Lai JR
Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa.
1. Nucleic Acids Res - published October 1, 2024
2. He S, Taher NM, Simard AR, Hvorecny KL, Ragusa MJ, Bahl CD, Hickman AB, Dyda F, Madden DR
Total Synthesis and Structural Reassignment of the Antitubercular Natural Product Evybactin.
1. Chemistry - published October 1, 2024
2. Lysenko V, Son S, Theriault ME, Slingerland CJ, Hauk G, Cleenewerk L, Speer A, Berger JM, Lewis K, Martin N
Advances and challenges in RAS signaling targeted therapy in leukemia.
1. Mol Cancer Ther - published October 1, 2024
2. Chen Y, Yin Z, Westover KD, Zhou Z, Shu L
Molecular basis of cell membrane adaptation in daptomycin-resistant Enterococcus faecalis.
1. JCI Insight - published October 1, 2024
2. Nguyen AH, Tran TT, Panesso D, Hood KS, Polamraju V, Zhang R, Khan A, Miller WR, Mileykovskaya E, Shamoo Y, Xu L, Vitrac H, Arias CA
GoToCloud optimization of cloud computing environment for accelerating cryo-EM structure-based drug design.
1. Commun Biol - published October 1, 2024
2. Moriya T, Yamada Y, Yamamoto M, Senda T
Characterization of conformational states of the homodimeric enzyme fluoroacetate dehalogenase by (19)F-(13)C two-dimensional NMR.
1. RSC Chem Biol - published October 1, 2024
2. Suleiman M, Frere GA, Törner R, Tabunar L, Bhole GV, Taverner K, Tsuchimura N, Pichugin D, Lichtenecker RJ, Vozny O, Gunning P, Arthanari H, Sljoka A, Prosser RS
TRPML1 gating modulation by allosteric mutations and lipids.
1. Elife - published October 1, 2024
2. Gan N, Han Y, Zeng W, Jiang Y
Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons.
1. Nat Biotechnol - published October 1, 2024
2. Hergenreder E, Minotti AP, Zorina Y, Oberst P, Zhao Z, Munguba H, Calder EL, Baggiolini A, Walsh RM, Liston C, Levitz J, Garippa R, Chen S, Ciceri G, Studer L
Fluorescent and bioluminescent bovine H5N1 influenza viruses for evaluation of antiviral interventions.
1. J Virol - published October 1, 2024
2. Trimarco JD, Spurrier MA, Skavicus S, Luo Z, Dutta M, Janowska K, Acharya P, Heaton BE, Heaton NS
Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation.
1. Proc Natl Acad Sci U S A - published October 1, 2024
2. Hu Y, Lopez VA, Xu H, Pfister JP, Song B, Servage KA, Sakurai M, Jones BT, Mendell JT, Wang T, Wu J, Lambowitz AM, Tomchick DR, Pawłowski K, Tagliabracci VS
Assessing Military Mental Health during the Pandemic: A Five Country Collaboration.
1. Curr Psychiatry Rep - published October 1, 2024
2. Lee JEC, Bennett C, Bennett N, Bouak F, Goldenberg I, Harrison K, Edge HM, Bell AM, Quartana PJ, Simms MA, Adler AB
Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.
1. Nat Commun - published October 1, 2024
2. Scott DC, Dharuman S, Griffith E, Chai SC, Ronnebaum J, King MT, Tangallapally R, Lee C, Gee CT, Yang L, Li Y, Loudon VC, Lee HW, Ochoada J, Miller DJ, Jayasinghe T, Paulo JA, Elledge SJ, Harper JW, Chen T, Lee RE, Schulman BA
Native Mass Spectrometry of Membrane Protein-Lipid Interactions in Different Detergent Environments.
1. Anal Chem - published October 1, 2024
2. Kumar S, Stover L, Wang L, Bahramimoghaddam H, Zhou M, Russell DH, Laganowsky A
Enhancing Spectrometer Performance with Unsupervised Machine Learning.
1. J Phys Chem B - published October 1, 2024
2. Harding BD, Hu Z, Hiett A, Delaglio F, Henzler-Wildman KA, Rienstra CM
Structures of the Foamy virus fusion protein reveal an unexpected link with the F protein of paramyxo- and pneumoviruses.
1. Sci Adv - published October 1, 2024
2. Fernández I, Bontems F, Brun D, Coquin Y, Goverde CA, Correia BE, Gessain A, Buseyne F, Rey FA, Backovic M
How bacteria initiate DNA replication comes into focus.
1. Bioessays - published October 1, 2024
2. Rashid F, Berger JM
Erratum: Studying Orthodontic Tooth Movement in Mice.
1. J Vis Exp - published October 1, 2024
2. Dukes MJ, Gilmore BL, Tanner JR, McDonald SM, Kelly DF
Molecular architecture and functional dynamics of the pre-incision complex in nucleotide excision repair.
1. Nat Commun - published October 1, 2024
2. Yu J, Yan C, Paul T, Brewer L, Tsutakawa SE, Tsai CL, Hamdan SM, Tainer JA, Ivanov I
Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition.
1. Oncotarget - published October 1, 2024
2. Rackear M, Quijano E, Ianniello Z, Colón-Ríos DA, Krysztofiak A, Abdullah R, Liu Y, Rogers FA, Ludwig DL, Dwivedi R, Bleichert F, Glazer PM
The molecular dissection of TRIM25's RNA-binding mechanism provides key insights into its antiviral activity.
1. Nat Commun - published October 1, 2024
2. Álvarez L, Haubrich K, Iselin L, Gillioz L, Ruscica V, Lapouge K, Augsten S, Huppertz I, Choudhury NR, Simon B, Masiewicz P, Lethier M, Cusack S, Rittinger K, Gabel F, Leitner A, Michlewski G, Hentze MW, Allain FHT, Castello A, Hennig J
The structural landscape of Microprocessor-mediated processing of pri-let-7 miRNAs.
1. Mol Cell - published October 1, 2024
2. Garg A, Shang R, Cvetanovic T, Lai EC, Joshua-Tor L
Factors associated with the choice of treatment for coronoid fractures.
1. Bone Joint J - published October 1, 2024
2. de Klerk HH, Verweij LPE, Doornberg JN, Jaarsma RL, Murase T, Chen NC, van den Bekerom MPJ, and the Elbow Injury Management Consortium, and the Elbow Injury Management Consortium (EIMC), Al K, Ar B, Ac W, A VT, Ac AP, A T, A B, B M, B T, B J, Cs M, Cm L, Cg L, Cg T, C R, D R, Ds R, D E, E AG, E K, Et E, Gi B, Jn L, Ja W, J P, J A, K S, K S, Al B, Ms C, M M, Ml R, Mj S, N A, N W, Nwl S, P A, P M, R B, Rj T, R VR, R G, S S, Sd D, S T, T M, Y C
Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking, and modulation of kinase activity.
1. Protein Sci - published October 1, 2024
2. Narayanan D, Larsen ASG, Gauger SJ, Adafia R, Hammershøi RB, Hamborg L, Bruus-Jensen J, Griem-Krey N, Gee CL, Frølund B, Stratton MM, Kuriyan J, Kastrup JS, Langkilde AE, Wellendorph P, Solbak SMØ
Analysis of EGFR binding hotspots for design of new EGFR inhibitory biologics.
1. Protein Sci - published October 1, 2024
2. Tydings CW, Singh B, Smith AW, Ledwitch KV, Brown BP, Lovly CM, Walker AS, Meiler J
Ternary structure of Plasmodium vivaxN-myristoyltransferase with myristoyl-CoA and inhibitor IMP-0001173.
1. Acta Crystallogr F Struct Biol Commun - published October 1, 2024
2. Bolling C, Mendez A, Taylor S, Makumire S, Reers A, Zigweid R, Subramanian S, Dranow DM, Staker B, Edwards TE, Tate EW, Bell AS, Myler PJ, Asojo OA, Chakafana G
Structural basis for adhesin secretion by the outer-membrane usher in type 1 pili.
1. Proc Natl Acad Sci U S A - published October 1, 2024
2. Bitter RM, Zimmerman MI, Summers BT, Pinkner JS, Dodson KW, Hultgren SJ, Yuan P
Alternating access of a bacterial homolog of neurotransmitter: sodium symporters determined from AlphaFold2 ensembles and DEER spectroscopy.
1. Proc Natl Acad Sci U S A - published October 1, 2024
2. Schwartz AC, Stein RA, Gil-Iturbe E, Quick M, Mchaourab HS
Biochemical simulation of mutation synthesis and repair during SARS-CoV-2 RNA polymerization.
1. Virology - published October 1, 2024
2. Oo A, Chen Z, Cao D, Cho YJ, Liang B, Schinazi RF, Kim B
Inherited PURA Pathogenic Variant Associated With a Mild Neurodevelopmental Disorder.
1. Neurol Genet - published October 1, 2024
2. Hildebrand MS, Braden RO, Lauretta ML, Kaspi A, Leventer RJ, Anderson M, Goel H, Bahlo M, Scheffer IE, Amor DJ, Janowski R, Niessing D, Morgan AT
Structural analysis and shape-based identification of novel inhibitors targeting the Trypanosoma cruzi proteasome.
1. Int J Biol Macromol - published October 1, 2024
2. Silva GM, Gomes SQ, Lopes CD, de Albuquerque S, de Paula da Silva CHT