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122 Member Publications for June

Previous Month

Switching the Post-translational Modification of Translation Elongation Factor EF-P.
1. Front Microbiol - published June 11, 2019
2. Volkwein W, Krafczyk R, Jagtap PKA, Parr M, Mankina E, Macošek J, Guo Z, Fürst MJLJ, Pfab M, Frishman D, Hennig J, Jung K, Lassak J
2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin.
1. FEBS Lett - published June 8, 2019
2. Moseng MA, Nix JC, Page RC
Heteromeric neuronal nicotinic acetylcholine receptors with mutant beta subunits acquire sensitivity to α7-selective positive allosteric modulators.
1. J Pharmacol Exp Ther - published June 7, 2019
2. Stokes C, Garai S, Kulkarni AR, Cantwell LN, Noviello CM, Hibbs RE, Horenstein NA, Abboud KA, Thakur GA, Papke RL
Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase.
1. FEBS Lett - published June 7, 2019
2. Czyzyk DJ, Valhondo M, Jorgensen WL, Anderson KS
Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2.
1. Genes Dev - published June 6, 2019
2. Plys AJ, Davis CP, Kim J, Rizki G, Keenen MM, Marr SK, Kingston RE
REC114 Partner ANKRD31 Controls Number, Timing, and Location of Meiotic DNA Breaks.
1. Mol Cell - published June 6, 2019
2. Boekhout M, Karasu ME, Wang J, Acquaviva L, Pratto F, Brick K, Eng DY, Xu J, Camerini-Otero RD, Patel DJ, Keeney S
RNA-guided DNA insertion with CRISPR-associated transposases.
1. Science - published June 6, 2019
2. Strecker J, Ladha A, Gardner Z, Schmid-Burgk JL, Makarova KS, Koonin EV, Zhang F
Correction: Trinh, H.V., et al. Humoral Response to the HIV-1 Envelope V2 Region in a Thai Early Acute Infection Cohort. Cells 2019, 8, 365.
1. Cells - published June 6, 2019
2. Trinh HV, Gohain N, Pham PT, Hamlin C, Song H, Sanders-Buell E, Bose M, Eller LA, Jain S, Uritskiy G, Rao VB, Tovanabutra S, Michael NL, Robb ML, Joyce MG, Rao M
The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors.
1. Ann N Y Acad Sci - published June 6, 2019
2. Morgan RK, Anderson GR, Araç D, Aust G, Balenga N, Boucard A, Bridges JP, Engel FB, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Prömel S, Scholz N, Srivastava S, Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum U, Wright KM, Monk KR, Mogha A
Application of Omics and Bioinformatics Tools in Streptococcus Research.
1. Curr Issues Mol Biol - published June 5, 2019
2. Liao M, Tong T, Zong Y, Zhou X, Cheng L, Huang R, Ren B, Alterovitz G
A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology.
1. Sci Transl Med - published June 5, 2019
2. Gerez JA, Prymaczok NC, Rockenstein E, Herrmann US, Schwarz P, Adame A, Enchev RI, Courtheoux T, Boersema PJ, Riek R, Peter M, Aguzzi A, Masliah E, Picotti P
Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress.
1. Nat Chem Biol - published June 4, 2019
2. Tsvetkov P, Detappe A, Cai K, Keys HR, Brune Z, Ying W, Thiru P, Reidy M, Kugener G, Rossen J, Kocak M, Kory N, Tsherniak A, Santagata S, Whitesell L, Ghobrial IM, Markley JL, Lindquist S, Golub TR
I-PINE web server: an integrative probabilistic NMR assignment system for proteins.
1. J Biomol NMR - published June 4, 2019
2. Lee W, Bahrami A, Dashti HT, Eghbalnia HR, Tonelli M, Westler WM, Markley JL
ALS-Linked Mutations Affect UBQLN2 Oligomerization and Phase Separation in a Position- and Amino Acid-Dependent Manner.
1. Structure - published June 4, 2019
2. Dao TP, Martyniak B, Canning AJ, Lei Y, Colicino EG, Cosgrove MS, Hehnly H, Castañeda CA
Clamping Together Hemidesmosomes and Latching Them in Place.
1. Structure - published June 4, 2019
2. Boggon TJ
Molecular models should not be published without the corresponding atomic coordinates.
1. Proc Natl Acad Sci U S A - published June 4, 2019
2. Graham SC, Nagar B, Privé GG, Deane JE
A Proteomic Screen of Neuronal Cell-Surface Molecules Reveals IgLONs as Structurally Conserved Interaction Modules at the Synapse.
1. Structure - published June 4, 2019
2. Ranaivoson FM, Turk LS, Ozgul S, Kakehi S, von Daake S, Lopez N, Trobiani L, De Jaco A, Denissova N, Demeler B, Özkan E, Montelione GT, Comoletti D
Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling.
1. Cell Rep - published June 4, 2019
2. Pascolutti R, Algisi V, Conte A, Raimondi A, Pasham M, Upadhyayula S, Gaudin R, Maritzen T, Barbieri E, Caldieri G, Tordonato C, Confalonieri S, Freddi S, Malabarba MG, Maspero E, Polo S, Tacchetti C, Haucke V, Kirchhausen T, Di Fiore PP, Sigismund S
Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity.
1. Cell Chem Biol - published June 3, 2019
2. Hafner M, Mills CE, Subramanian K, Chen C, Chung M, Boswell SA, Everley RA, Liu C, Walmsley CS, Juric D, Sorger PK
Peroxisome protein import recapitulated in Xenopus egg extracts.
1. J Cell Biol - published June 3, 2019
2. Romano FB, Blok NB, Rapoport TA
Heteroaryl Rings in Peptide Macrocycles.
1. Chem Rev - published June 3, 2019
2. Smolyar IV, Yudin AK, Nenajdenko VG
S-3-Carboxypropyl-L-cysteine specifically inhibits cystathionine γ-lyase-dependent hydrogen sulfide synthesis.
1. J Biol Chem - published June 3, 2019
2. Yadav PK, Vitvitsky V, Kim H, White A, Cho US, Banerjee R
Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
1. Mol Cell - published June 2, 2019
2. Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G
A TCR/superagonist/MHC complex shows similar interface and reduced flexibility compared to the complex with self-peptide.
1. Proteins - published June 2, 2019
2. Salutari I, Martin R, Caflisch A
A dedicated diribonucleotidase resolves a key bottleneck as the terminal step of RNA degradation.
1. Elife - published June 2, 2019
2. Kim SK, Lormand JD, Weiss CA, Eger KA, Turdiev H, Turdiev A, Winkler WC, Sondermann H, Lee VT
Structural Basis of an Asymmetric Condensin ATPase Cycle.
1. Mol Cell - published June 2, 2019
2. Hassler M, Shaltiel IA, Kschonsak M, Simon B, Merkel F, Thärichen L, Bailey HJ, Macošek J, Bravo S, Metz J, Hennig J, Haering CH
Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1).
1. Cancer Immunol Immunother - published June 2, 2019
2. Koumantou D, Barnea E, Martin-Esteban A, Maben Z, Papakyriakou A, Mpakali A, Kokkala P, Pratsinis H, Georgiadis D, Stern LJ, Admon A, Stratikos E
Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites.
1. Cell Chem Biol - published June 2, 2019
2. McNamara DE, Dovey CM, Hale AT, Quarato G, Grace CR, Guibao CD, Diep J, Nourse A, Cai CR, Wu H, Kalathur RC, Green DR, York JD, Carette JE, Moldoveanu T
STIM calcium sensing and conformational change.
1. J Physiol - published June 2, 2019
2. Gudlur A, Zeraik AE, Hirve N, Hogan PG
Activation and regulation of H2B-Ubiquitin-dependent histone methyltransferases.
1. Curr Opin Struct Biol - published June 2, 2019
2. Worden EJ, Wolberger C
In situ Structure of Rotavirus VP1 RNA-Dependent RNA Polymerase.
1. J Mol Biol - published June 2, 2019
2. Jenni S, Salgado EN, Herrmann T, Li Z, Grant T, Grigorieff N, Trapani S, Estrozi LF, Harrison SC
Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection.
1. PLoS Pathog - published June 2, 2019
2. Bensing BA, Li L, Yakovenko O, Wong M, Barnard KN, Iverson TM, Lebrilla CB, Parrish CR, Thomas WE, Xiong Y, Sullam PM
De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX.
1. J Med Chem - published June 2, 2019
2. Tan J, Grouleff JJ, Jitkova Y, Diaz DB, Griffith EC, Shao W, Bogdanchikova AF, Poda G, Schimmer AD, Lee RE, Yudin AK
Protection of abasic sites during DNA replication by a stable thiazolidine protein-DNA cross-link.
1. Nat Struct Mol Biol - published June 2, 2019
2. Thompson PS, Amidon KM, Mohni KN, Cortez D, Eichman BF
Structural basis of tubulin detyrosination by vasohibins.
1. Nat Struct Mol Biol - published June 2, 2019
2. Li F, Hu Y, Qi S, Luo X, Yu H
Structural basis for adenylation and thioester bond formation in the ubiquitin E1.
1. Proc Natl Acad Sci U S A - published June 2, 2019
2. Hann ZS, Ji C, Olsen SK, Lu X, Lux MC, Tan DS, Lima CD
X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1‑deoxy‑d‑xylulose 5-phosphate synthase reaction coordinate.
1. J Biol Chem - published June 2, 2019
2. Chen PY, DeColli AA, Freel Meyers CL, Drennan CL
tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay.
1. Elife - published June 2, 2019
2. Peschek J, Walter P
Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes.
1. Nat Commun - published June 2, 2019
2. Di Venanzio G, Flores-Mireles AL, Calix JJ, Haurat MF, Scott NE, Palmer LD, Potter RF, Hibbing ME, Friedman L, Wang B, Dantas G, Skaar EP, Hultgren SJ, Feldman MF
APOBEC3s: DNA-Editing Human Cytidine Deaminases.
1. Protein Sci - published June 2, 2019
2. Silvas TV, Schiffer CA
Conformational transitions of a neurotensin receptor 1-Gi1 complex.
1. Nature - published June 2, 2019
2. Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G
Cross-Linked Elastin-like Polypeptide Membranes as a Model for Medial Arterial Calcification.
1. Biomacromolecules - published June 2, 2019
2. Gourgas O, Muiznieks LD, Bello DG, Nanci A, Sharpe S, Cerruti M
Liquid-Cell Electron Tomography of Biological Systems.
1. Nano Lett - published June 2, 2019
2. Dearnaley WJ, Schleupner B, Varano AC, Alden NA, Gonzalez F, Casasanta MA, Scharf BE, Dukes MJ, Kelly DF
NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations.
1. J Biomol NMR - published June 2, 2019
2. Ishima R, Kurt Yilmaz N, Schiffer CA
A unified structural model of the mammalian translocator protein (TSPO).
1. J Biomol NMR - published June 2, 2019
2. Xia Y, Ledwitch K, Kuenze G, Duran A, Li J, Sanders CR, Manning C, Meiler J
First-generation predictors of biological protein phase separation.
1. Curr Opin Struct Biol - published June 2, 2019
2. Vernon RM, Forman-Kay JD
Structure of the Cdc48 segregase in the act of unfolding an authentic substrate.
1. Science - published June 2, 2019
2. Cooney I, Han H, Stewart MG, Carson RH, Hansen DT, Iwasa JH, Price JC, Hill CP, Shen PS
Solution structure and biochemical characterization of a spare part protein that restores activity to an oxygen-damaged glycyl radical enzyme.
1. J Biol Inorg Chem - published June 2, 2019
2. Bowman SEJ, Backman LRF, Bjork RE, Andorfer MC, Yori S, Caruso A, Stultz CM, Drennan CL
ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.
1. Cell Host Microbe - published June 2, 2019
2. Hüttenhain R, Xu J, Burton LA, Gordon DE, Hultquist JF, Johnson JR, Satkamp L, Hiatt J, Rhee DY, Baek K, Crosby DC, Frankel AD, Marson A, Harper JW, Alpi AF, Schulman BA, Gross JD, Krogan NJ
SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility.
1. J Cell Biol - published June 2, 2019
2. Awadia S, Huq F, Arnold TR, Goicoechea SM, Sun YJ, Hou T, Kreider-Letterman G, Massimi P, Banks L, Fuentes EJ, Miller AL, Garcia-Mata R
A phase 3 study of tezacaftor in combination with ivacaftor in children aged 6 through 11 years with cystic fibrosis.
1. J Cyst Fibros - published June 2, 2019
2. Walker S, Flume P, McNamara J, Solomon M, Chilvers M, Chmiel J, Harris RS, Haseltine E, Stiles D, Li C, Ahluwalia N, Zhou H, Owen CA, Sawicki G, VX15-661-113 Investigator Group.
CRISPR Base Editing in Induced Pluripotent Stem Cells.
1. Methods Mol Biol - published June 2, 2019
2. Chang YJ, Xu CL, Cui X, Bassuk AG, Mahajan VB, Tsai YT, Tsang SH
Direct observation of intermediates in the SufS cysteine desulfurase reaction reveals functional roles of conserved active-site residues.
1. J Biol Chem - published June 2, 2019
2. Blahut M, Wise CE, Bruno MR, Dong G, Makris TM, Frantom PA, Dunkle JA, Outten FW
Sequence variants of human tropoelastin affecting assembly, structural characteristics and functional properties of polymeric elastin in health and disease.
1. Matrix Biol - published June 2, 2019
2. Reichheld SE, Muiznieks LD, Lu R, Sharpe S, Keeley FW
A Transient and Flexible Cation-π Interaction Promotes Hydrolysis of Nucleic Acids in DNA and RNA Nucleases.
1. J Am Chem Soc - published June 2, 2019
2. Genna V, Marcia M, Vivo M
Mechanism of β2AR regulation by an intracellular positive allosteric modulator.
1. Science - published June 2, 2019
2. Liu X, Masoudi A, Kahsai AW, Huang LY, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B
Molecular adaptations of NADP-malic enzyme for its function in C4 photosynthesis in grasses.
1. Nat Plants - published June 2, 2019
2. Alvarez CE, Bovdilova A, Höppner A, Wolff CC, Saigo M, Trajtenberg F, Zhang T, Buschiazzo A, Nagel-Steger L, Drincovich MF, Lercher MJ, Maurino VG
Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development.
1. Elife - published June 2, 2019
2. Cho C, Wang Y, Smallwood PM, Williams J, Nathans J
An Ontology for Facilitating Discussion of Catalytic Strategies of RNA-Cleaving Enzymes.
1. ACS Chem Biol - published June 2, 2019
2. Bevilacqua PC, Harris ME, Piccirilli JA, Gaines C, Ganguly A, Kostenbader K, Ekesan Ş, York DM
Influence of size and charge of unstructured polypeptides on pharmacokinetics and biodistribution of targeted fusion proteins.
1. J Control Release - published June 2, 2019
2. Brandl F, Merten H, Zimmermann M, Béhé M, Zangemeister-Wittke U, Plückthun A
High-Throughput Quantification of Surface Protein Internalization and Degradation.
1. ACS Chem Biol - published June 2, 2019
2. Stüber JC, Kast F, Plückthun A
Structure of the substrate-engaged SecA-SecY protein translocation machine.
1. Nat Commun - published June 2, 2019
2. Ma C, Wu X, Sun D, Park E, Catipovic MA, Rapoport TA, Gao N, Li L
Rapid assembly and profiling of an anticoagulant sulfoprotein library.
1. Proc Natl Acad Sci U S A - published June 2, 2019
2. Watson EE, Ripoll-Rozada J, Lee AC, Wu MCL, Franck C, Pasch T, Premdjee B, Sayers J, Pinto MF, Martins PM, Jackson SP, Pereira PJB, Payne RJ
Target sequence requirements of a type III-B CRISPR-Cas immune system.
1. J Biol Chem - published June 2, 2019
2. Johnson K, Learn BA, Estrella MA, Bailey S
Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.
1. Science - published June 2, 2019
2. Twomey EC, Ji Z, Wales TE, Bodnar NO, Ficarro SB, Marto JA, Engen JR, Rapoport TA
Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2.
1. Nat Commun - published June 2, 2019
2. Thavalingam A, Cheng Z, Garcia B, Huang X, Shah M, Sun W, Wang M, Harrington L, Hwang S, Hidalgo-Reyes Y, Sontheimer EJ, Doudna J, Davidson AR, Moraes TF, Wang Y, Maxwell KL
Structural identification of a hotspot on CFTR for potentiation.
1. Science - published June 2, 2019
2. Liu F, Zhang Z, Levit A, Levring J, Touhara KK, Shoichet BK, Chen J
Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.
1. Mol Cell - published June 2, 2019
2. Ali I, Ruiz DG, Ni Z, Johnson JR, Zhang H, Li PC, Khalid MM, Conrad RJ, Guo X, Min J, Greenblatt J, Jacobson M, Krogan NJ, Ott M
Shaping Striated Muscles with Ubiquitin Proteasome System in Health and Disease.
1. Trends Mol Med - published June 2, 2019
2. Hnia K, Clausen T, Moog-Lutz C
Two-Component Sensing and Regulation: How Do Histidine Kinases Talk with Response Regulators at the Molecular Level?
1. Annu Rev Microbiol - published June 2, 2019
2. Buschiazzo A, Trajtenberg F
Molecular Mechanism of HIV-1 Entry.
1. Trends Microbiol - published June 2, 2019
2. Chen B
Molecular and cellular studies evaluating a potent 2-cyanoindolizine catechol diether NNRTI targeting wildtype and Y181C mutant HIV-1 reverse transcriptase.
1. Bioorg Med Chem Lett - published June 2, 2019
2. Sasaki T, Gannam ZTK, Kudalkar SN, Frey KM, Lee WG, Spasov KA, Jorgensen WL, Anderson KS
Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope.
1. Immunity - published June 1, 2019
2. Schoofs T, Barnes CO, Suh-Toma N, Golijanin J, Schommers P, Gruell H, West AP Jr, Bach F, Lee YE, Nogueira L, Georgiev IS, Bailer RT, Czartoski J, Mascola JR, Seaman MS, McElrath MJ, Doria-Rose NA, Klein F, Nussenzweig MC, Bjorkman PJ
Structural snapshots of actively transcribing influenza polymerase.
1. Nat Struct Mol Biol - published June 1, 2019
2. Kouba T, Drncová P, Cusack S
The structure of the yeast Ctf3 complex.
1. Elife - published June 1, 2019
2. Hinshaw SM, Dates AN, Harrison SC
MHC-I peptide binding activity assessed by exchange after cleavage of peptide covalently linked to β2-microglobulin.
1. Anal Biochem - published June 1, 2019
2. Jurewicz MM, Willis RA, Altman JD, Stern LJ
A driving test for oncogenic mutations.
1. J Biol Chem - published June 1, 2019
2. Heppner DE, Beyett TS, Eck MJ
Evolving SAXS versatility: solution X-ray scattering for macromolecular architecture, functional landscapes, and integrative structural biology.
1. Curr Opin Struct Biol - published June 1, 2019
2. Brosey CA, Tainer JA
Conformational switches control early maturation of the eukaryotic small ribosomal subunit.
1. Elife - published June 1, 2019
2. Hunziker M, Barandun J, Buzovetsky O, Steckler C, Molina H, Klinge S
CM01: a facility for cryo-electron microscopy at the European Synchrotron.
1. Acta Crystallogr D Struct Biol - published June 1, 2019
2. Kandiah E, Giraud T, de Maria Antolinos A, Dobias F, Effantin G, Flot D, Hons M, Schoehn G, Susini J, Svensson O, Leonard GA, Mueller-Dieckmann C
Structure of the Helicobacter pylori Cag Type IV secretion system.
1. Elife - published June 1, 2019
2. Chung JM, Sheedlo MJ, Campbell AM, Sawhney N, Frick-Cheng AE, Lacy DB, Cover TL, Ohi MD
GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase.
1. Nat Struct Mol Biol - published June 1, 2019
2. Kuchay S, Wang H, Marzio A, Jain K, Homer H, Fehrenbacher N, Philips MR, Zheng N, Pagano M
Genetic Variants in EGFR/PLCE1 Pathway Are Associated with Prognosis of Esophageal Squamous Cell Carcinoma after Radical Resection.
1. Curr Med Sci - published June 1, 2019
2. Wang YL, Yuan Y, Luo XX, Hu GY, Gong P
Potentiation of ABCA3 lipid transport function by ivacaftor and genistein.
1. J Cell Mol Med - published June 1, 2019
2. Kinting S, Li Y, Forstner M, Delhommel F, Sattler M, Griese M
Biomaterials in non-integer dimensions.
1. Nat Chem - published June 1, 2019
2. Young ID, Fraser JS
A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+ Treg cell development.
1. Nat Immunol - published June 1, 2019
2. Stadinski BD, Blevins SJ, Spidale NA, Duke BR, Huseby PG, Stern LJ, Huseby ES
Targeting BAX to drug death directly.
1. Nat Chem Biol - published June 1, 2019
2. Walensky LD
Sera Antibody Repertoire Analyses Reveal Mechanisms of Broad and Pandemic Strain Neutralizing Responses after Human Norovirus Vaccination.
1. Immunity - published June 1, 2019
2. Lindesmith LC, McDaniel JR, Changela A, Verardi R, Kerr SA, Costantini V, Brewer-Jensen PD, Mallory ML, Voss WN, Boutz DR, Blazeck JJ, Ippolito GC, Vinje J, Kwong PD, Georgiou G, Baric RS
Disrupting LILRB4/APOE interaction by an efficacious humanized antibody reverses T-cell suppression and blocks AML development.
1. Cancer Immunol Res - published June 1, 2019
2. Gui X, Deng M, Song H, Chen Y, Xie J, Li Z, He L, Huang F, Xu Y, Anami Y, Yu H, Yu C, Li L, Yuan Z, Xu X, Wang Q, Chai Y, Huang T, Shi Y, Tsuchikama K, Liao XC, Xia N, Gao GF, Zhang N, Zhang C, An Z
Peripheral myelin protein 22 modulates store operated calcium channel activity, providing insights into Charcot-Marie-Tooth disease etiology.
1. J Biol Chem - published June 1, 2019
2. Vanoye CG, Sakakura M, Follis RM, Trevisan AJ, Narayan M, Li J, Sanders CR, Carter BD
Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex.
1. Nat Commun - published June 1, 2019
2. Gauto DF, Estrozi LF, Schwieters CD, Effantin G, Macek P, Sounier R, Sivertsen AC, Schmidt E, Kerfah R, Mas G, Colletier JP, Güntert P, Favier A, Schoehn G, Schanda P, Boisbouvier J
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.
1. Nature - published June 1, 2019
2. Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, Golas AJ, Guinn KM, Kennedy S, Korn R, McConnell JA, Moss CE, Murphy KC, Nietupski RM, Papavinasasundaram KG, Pinkham JT, Pino PA, Proulx MK, Ruecker N, Song N, Thompson M, Trujillo C, Wakabayashi S, Wallach JB, Watson C, Ioerger TR, Lander ES, Hubbard BK, Serrano-Wu MH, Ehrt S, Fitzgerald M, Rubin EJ, Sassetti CM, Schnappinger D, Hung DT
Viral Capsid Trafficking along Treadmilling Tubulin Filaments in Bacteria.
1. Cell - published June 1, 2019
2. Chaikeeratisak V, Khanna K, Nguyen KT, Sugie J, Egan ME, Erb ML, Vavilina A, Nonejuie P, Nieweglowska E, Pogliano K, Agard DA, Villa E, Pogliano J
Telomerase structures and regulation: shedding light on the chromosome end.
1. Curr Opin Struct Biol - published June 1, 2019
2. Nguyen THD, Collins K, Nogales E
Composition of the holdfast polysaccharide from Caulobacter crescentus.
1. J Bacteriol - published June 1, 2019
2. Hershey DM, Porfírio S, Black I, Jaehrig B, Heiss C, Azadi P, Fiebig A, Crosson S
Nucleic Acid Detection of Plant Genes Using CRISPR-Cas13.
1. CRISPR J - published June 1, 2019
2. Abudayyeh OO, Gootenberg JS, Kellner MJ, Zhang F
Are opioids pediatric anesthesiologists' sword of Damocles? With great power comes great responsibility and risk.
1. Paediatr Anaesth - published June 1, 2019
2. Chalkiadis G, Goobie S, Walker S
HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP.
1. Mol Cell - published June 1, 2019
2. Lane EA, Choi DW, Garcia-Haro L, Levine ZG, Tedoldi M, Walker S, Danial NN
A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis.
1. Cell Host Microbe - published June 1, 2019
2. Lee S, Liu H, Wilen CB, Sychev ZE, Desai C, Hykes BL Jr, Orchard RC, McCune BT, Kim KW, Nice TJ, Handley SA, Baldridge MT, Amarasinghe GK, Virgin HW
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.
1. Nat Commun - published June 1, 2019
2. Minuesa G, Albanese SK, Xie W, Kazansky Y, Worroll D, Chow A, Schurer A, Park SM, Rotsides CZ, Taggart J, Rizzi A, Naden LN, Chou T, Gourkanti S, Cappel D, Passarelli MC, Fairchild L, Adura C, Glickman JF, Schulman J, Famulare C, Patel M, Eibl JK, Ross GM, Bhattacharya S, Tan DS, Leslie CS, Beuming T, Patel DJ, Goldgur Y, Chodera JD, Kharas MG
Anthracycline dose optimisation in patients with diffuse large B-cell lymphoma: a multicentre, phase 3, randomised, controlled trial.
1. Lancet Haematol - published June 1, 2019
2. Xu PP, Fu D, Li JY, Hu JD, Wang X, Zhou JF, Yu H, Zhao X, Huang YH, Jiang L, Liu F, Su LP, Chen ZW, Zeng QS, Chen JP, Fang MY, Ma J, Liu T, Song YP, Yu K, Li Y, Qiu LG, Chen XQ, Gu J, Yan JS, Hou M, Huang HY, Wang L, Cheng S, Shen Y, Xiong H, Chen SJ, Zhao WL
DNA Microscopy: Optics-free Spatio-genetic Imaging by a Stand-Alone Chemical Reaction.
1. Cell - published June 1, 2019
2. Weinstein JA, Regev A, Zhang F
Gene Transfer with AAV9-PHP.B Rescues Hearing in a Mouse Model of Usher Syndrome 3A and Transduces Hair Cells in a Non-human Primate.
1. Mol Ther Methods Clin Dev - published June 1, 2019
2. György B, Meijer EJ, Ivanchenko MV, Tenneson K, Emond F, Hanlon KS, Indzhykulian AA, Volak A, Karavitaki KD, Tamvakologos PI, Vezina M, Berezovskii VK, Born RT, O'Brien M, Lafond JF, Arsenijevic Y, Kenna MA, Maguire CA, Corey DP
Convergent allostery in ribonucleotide reductase.
1. Nat Commun - published June 1, 2019
2. Thomas WC, Brooks FP 3rd, Burnim AA, Bacik JP, Stubbe J, Kaelber JT, Chen JZ, Ando N
Specific high affinity interaction of Helicobacter pylori CagL with integrin αV β6 promotes type IV secretion of CagA into human cells.
1. FEBS J - published June 1, 2019
2. Buß M, Tegtmeyer N, Schnieder J, Dong X, Li J, Springer TA, Backert S, Niemann HH
Severe influenza pneumonitis in children with inherited TLR3 deficiency.
1. J Exp Med - published June 1, 2019
2. Lim HK, Huang SXL, Chen J, Kerner G, Gilliaux O, Bastard P, Dobbs K, Hernandez N, Goudin N, Hasek ML, García Reino EJ, Lafaille FG, Lorenzo L, Luthra P, Kochetkov T, Bigio B, Boucherit S, Rozenberg F, Vedrinne C, Keller MD, Itan Y, García-Sastre A, Celard M, Orange JS, Ciancanelli MJ, Meyts I, Zhang Q, Abel L, Notarangelo LD, Snoeck HW, Casanova JL, Zhang SY
Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity.
1. J Med Chem - published June 1, 2019
2. Velagapudi UK, Langelier MF, Delgado-Martin C, Diolaiti ME, Bakker S, Ashworth A, Patel BA, Shao X, Pascal JM, Talele TT
In trans variant calling reveals enrichment for compound heterozygous variants in genes involved in neuronal development and growth.
1. Genet Res (Camb) - published June 1, 2019
2. Cox AJ, Grady F, Velez G, Mahajan VB, Ferguson PJ, Kitchen A, Darbro BW, Bassuk AG
Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome.
1. Elife - published June 1, 2019
2. Armache JP, Gamarra N, Johnson SL, Leonard JD, Wu S, Narlikar GJ, Cheng Y
Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins.
1. Sci Adv - published June 1, 2019
2. Yen TJ, Lolicato M, Thomas-Tran R, Du Bois J, Minor DL Jr
Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation.
1. Cancer Discov - published June 1, 2019
2. Gu Z, Liu Y, Cai F, Patrick M, Zmajkovic J, Cao H, Zhang Y, Tasdogan A, Chen M, Qi L, Liu X, Li K, Lyu J, Dickerson KE, Chen W, Ni M, Merritt ME, Morrison SJ, Skoda RC, DeBerardinis RJ, Xu J
iScore: A novel graph kernel-based function for scoring protein-protein docking models.
1. Bioinformatics - published June 1, 2019
2. Geng C, Jung Y, Renaud N, Honavar V, Bonvin AMJJ, Xue LC
Traumatic chorioretinitis sclopetaria: Risk factors, management, and prognosis.
1. Am J Ophthalmol Case Rep - published June 1, 2019
2. Ludwig CA, Shields RA, Do DV, Moshfeghi DM, Mahajan VB
Brucella Periplasmic Protein EipB Is a Molecular Determinant of Cell Envelope Integrity and Virulence.
1. J Bacteriol - published June 1, 2019
2. Herrou J, Willett JW, Fiebig A, Czyż DM, Cheng JX, Ultee E, Briegel A, Bigelow L, Babnigg G, Kim Y, Crosson S
The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy.
1. Nat Commun - published June 1, 2019
2. Fu Z, Indrisiunaite G, Kaledhonkar S, Shah B, Sun M, Chen B, Grassucci RA, Ehrenberg M, Frank J
[Evidence-based recommendations for the revision of the Austrian periodic health examination].
1. Wien Med Wochenschr - published June 1, 2019
2. Sommer I, Titscher V, Teufer B, Klerings I, Nußbaumer-Streit B, Szelag M, Affengruber L, Wagner G, Glechner A, Kien C, Ebenberger A, Schiller-Frühwirth I, Dorner TE, Siebenhofer A, Haditsch B, Bachler H, Siebert U, Gartlehner G
High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations.
1. Proc Natl Acad Sci U S A - published June 1, 2019
2. Jung J, Grant T, Thomas DR, Diehnelt CW, Grigorieff N, Joshua-Tor L
F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects.
1. J Allergy Clin Immunol - published June 1, 2019
2. Calzoni E, Platt CD, Keles S, Kuehn HS, Beaussant-Cohen S, Zhang Y, Pazmandi J, Lanzi G, Pala F, Tahiat A, Artac H, Heredia RJ, Dmytrus J, Reisli I, Uygun V, Uygun D, Bingol A, Basaran E, Djenouhat K, Benhalla N, Bendahmane C, Emiroglu M, Kirchhausen T, Pasham M, Jones J, Wallace JG, Zheng L, Boisson B, Porta F, Rosenzweig SD, Su H, Giliani S, Lenardo M, Geha RS, Boztug K, Chou J, Notarangelo LD
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
1. Proc Natl Acad Sci U S A - published June 1, 2019
2. Xie W, Lama L, Adura C, Tomita D, Glickman JF, Tuschl T, Patel DJ
Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases.
1. Elife - published June 1, 2019
2. Han H, Fulcher JM, Dandey VP, Iwasa JH, Sundquist WI, Kay MS, Shen PS, Hill CP
The EGFR Exon 19 Mutant L747-A750>P Exhibits Distinct Sensitivity to Tyrosine Kinase Inhibitors in Lung Adenocarcinoma.
1. Clin Cancer Res - published June 1, 2019
2. Truini A, Starrett JH, Stewart TF, Ashtekar KD, Walther Z, Wurtz A, Lu D, Park JH, DeVeaux M, Song X, Gettinger S, Zelterman D, Lemmon MA, Goldberg SB, Politi K
Fimbriae reprogram host gene expression - Divergent effects of P and type 1 fimbriae.
1. PLoS Pathog - published June 1, 2019
2. Ambite I, Butler DSC, Stork C, Grönberg-Hernández J, Köves B, Zdziarski J, Pinkner J, Hultgren SJ, Dobrindt U, Wullt B, Svanborg C