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78 Member Publications for September

Previous Month

A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation.
1. Nat Metab - published September 9, 2021
2. Li L, Conradson DM, Bharat V, Kim MJ, Hsieh CH, Minhas PS, Papakyrikos AM, Durairaj AS, Ludlam A, Andreasson KI, Partridge L, Cianfrocco MA, Wang X
What's in the Black Box? - A Perspective on Software in Cryo-Electron Microscopy.
1. Biophys J - published September 9, 2021
2. Maji S, Frank J
Molecular investigation of artificial and natural sweeteners as potential anti-inflammatory agents.
1. J Biomol Struct Dyn - published September 9, 2021
2. Chontzopoulou E, Papaemmanouil CD, Chatziathanasiadou MV, Kolokouris D, Kiriakidi S, Konstantinidi A, Gerogianni I, Tselios T, Kostakis IK, Chrysina ED, Hadjipavlou-Litina D, Tzeli D, Tzakos AG, Mavromoustakos T
Structure of mitotic chromosomes.
1. Mol Cell - published September 8, 2021
2. Beel AJ, Azubel M, Matteï PJ, Kornberg RD
Imaging of retina cellular and subcellular structures using ptychographic hard X-ray tomography.
1. J Cell Sci - published September 8, 2021
2. Panneels V, Diaz A, Imsand C, Guizar-Sicairos M, Müller E, Bittermann AG, Ishikawa T, Menzel A, Kaech A, Holler M, Grimm C, Schertler G
Systematic engineering of optimized autonomous heavy-chain variable domains.
1. J Mol Biol - published September 8, 2021
2. Nilvebrant J, Ereño-Orbea J, Gorelik M, Julian MC, Tessier PM, Julien JP, Sidhu SS
Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies.
1. Cell Rep - published September 8, 2021
2. Jette CA, Cohen AA, Gnanapragasam PNP, Muecksch F, Lee YE, Huey-Tubman KE, Schmidt F, Hatziioannou T, Bieniasz PD, Nussenzweig MC, West AP Jr, Keeffe JR, Bjorkman PJ, Barnes CO
Bioaccumulation of therapeutic drugs by human gut bacteria.
1. Nature - published September 8, 2021
2. Klünemann M, Andrejev S, Blasche S, Mateus A, Phapale P, Devendran S, Vappiani J, Simon B, Scott TA, Kafkia E, Konstantinidis D, Zirngibl K, Mastrorilli E, Banzhaf M, Mackmull MT, Hövelmann F, Nesme L, Brochado AR, Maier L, Bock T, Periwal V, Kumar M, Kim Y, Tramontano M, Schultz C, Beck M, Hennig J, Zimmermann M, Sévin DC, Cabreiro F, Savitski MM, Bork P, Typas A, Patil KR
Open Reading Frame 1 Protein of the Human Long Interspersed Nuclear Element 1 Retrotransposon Binds Multiple Equivalents of Lead.
1. J Am Chem Soc - published September 8, 2021
2. Pinter TBJ, Ruckthong L, Stuckey JA, Deb A, Penner-Hahn JE, Pecoraro VL
Structure of SARS-CoV-2 spike protein.
1. Curr Opin Virol - published September 8, 2021
2. Zhang J, Xiao T, Cai Y, Chen B
Biochemical reconstitution defines new functions for membrane-bound glycosidases in assembly of the bacterial cell wall.
1. Proc Natl Acad Sci U S A - published September 7, 2021
2. Taguchi A, Page JE, Tsui HT, Winkler ME, Walker S
The enigmatic Placozoa part 2: Exploring evolutionary controversies and promising questions on earth and in space.
1. Bioessays - published September 7, 2021
2. Schierwater B, Osigus HJ, Bergmann T, Blackstone NW, Hadrys H, Hauslage J, Humbert PO, Kamm K, Kvansakul M, Wysocki K, DeSalle R
Targeting the Nuclear Receptor-Binding SET Domain Family of Histone Lysine Methyltransferases for Cancer Therapy: Recent Progress and Perspectives.
1. J Med Chem - published September 7, 2021
2. Shrestha A, Kim N, Lee SJ, Jeon YH, Song JJ, An H, Cho SJ, Kadayat TM, Chin J
In Situ Covalent Functionalization of DNA Origami Virus-like Particles.
1. ACS Nano - published September 7, 2021
2. Knappe GA, Wamhoff EC, Read BJ, Irvine DJ, Bathe M
The structural basis of Salmonella A₂B₅ toxin neutralization by antibodies targeting the glycan-receptor binding subunits.
1. Cell Rep - published September 7, 2021
2. Nguyen T, Richards AF, Neupane DP, Feathers JR, Yang YA, Sim JH, Byun H, Lee S, Ahn C, Van Slyke G, Fromme JC, Mantis NJ, Song J
Clostridioides difficile infection induces a rapid influx of bile acids into the gut during colonization of the host.
1. Cell Rep - published September 7, 2021
2. Wexler AG, Guiberson ER, Beavers WN, Shupe JA, Washington MK, Lacy DB, Caprioli RM, Spraggins JM, Skaar EP
SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma.
1. Proc Natl Acad Sci U S A - published September 7, 2021
2. Andreano E, Piccini G, Licastro D, Casalino L, Johnson NV, Paciello I, Dal Monego S, Pantano E, Manganaro N, Manenti A, Manna R, Casa E, Hyseni I, Benincasa L, Montomoli E, Amaro RE, McLellan JS, Rappuoli R
Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
1. Proc Natl Acad Sci U S A - published September 7, 2021
2. Gonzalez-Del Pino GL, Li K, Park E, Schmoker AM, Ha BH, Eck MJ
Obligate movements of an active site-linked surface domain control RNA polymerase elongation and pausing via a Phe pocket anchor.
1. Proc Natl Acad Sci U S A - published September 7, 2021
2. Bao Y, Landick R
Cyclodextrins increase membrane tension and are universal activators of mechanosensitive channels.
1. Proc Natl Acad Sci U S A - published September 7, 2021
2. Cox CD, Zhang Y, Zhou Z, Walz T, Martinac B
Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens.
1. Nat Commun - published September 6, 2021
2. Hwang MS, Miller MS, Thirawatananond P, Douglass J, Wright KM, Hsiue EH, Mog BJ, Aytenfisu TY, Murphy MB, Aitana Azurmendi P, Skora AD, Pearlman AH, Paul S, DiNapoli SR, Konig MF, Bettegowda C, Pardoll DM, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S, Gabelli SB
Computational study of non-conductive selectivity filter conformations and C-type inactivation in a voltage-dependent potassium channel.
1. J Gen Physiol - published September 6, 2021
2. Li J, Shen R, Rohaim A, Mendoza Uriarte R, Fajer M, Perozo E, Roux B
New Advances in the Research of Resistance to Neoadjuvant Chemotherapy in Breast Cancer.
1. Int J Mol Sci - published September 6, 2021
2. An J, Peng C, Tang H, Liu X, Peng F
Structural basis for the recognition of deaminated nucleobases by an archaeal DNA polymerase.
1. Chembiochem - published September 6, 2021
2. Marx A, Kropp HM, Ludmann S, Diederichs K, Betz K
Publisher Correction: JunB is a key regulator of multiple myeloma bone marrow angiogenesis.
1. Leukemia - published September 6, 2021
2. Fan F, Malvestiti S, Vallet S, Lind J, Garcia-Manteiga JM, Morelli E, Jiang Q, Seckinger A, Hose D, Goldschmidt H, Stadlbauer A, Sun C, Mei H, Pecherstorfer M, Bakiri L, Wagner EF, Tonon G, Sattler M, Hu Y, Tassone P, Jaeger D, Podar K
Aurora A kinase activation: Different means to different ends.
1. J Cell Biol - published September 6, 2021
2. Tavernier N, Sicheri F, Pintard L
Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism.
1. Nat Commun - published September 6, 2021
2. Maben Z, Arya R, Georgiadis D, Stratikos E, Stern LJ
The Macromolecular Complexes of Histones Affect Protein Arginine Methyltransferase Activities.
1. J Biol Chem - published September 4, 2021
2. Fulton MD, Cao M, Ho MC, Zhao X, Zheng YG
Cristae-dependent quality control of the mitochondrial genome.
1. Sci Adv - published September 3, 2021
2. Jakubke C, Roussou R, Maiser A, Schug C, Thoma F, Bunk D, Hörl D, Leonhardt H, Walter P, Klecker T, Osman C
Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile.
1. iScience - published September 2, 2021
2. Rujas E, Leaman DP, Insausti S, Carravilla P, García-Porras M, Largo E, Morillo I, Sánchez-Eugenia R, Zhang L, Cui H, Iloro I, Elortza F, Julien JP, Eggeling C, Zwick MB, Caaveiro JMM, Nieva JL
The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB.
1. Nat Commun - published September 2, 2021
2. Safarian S, Opel-Reading HK, Wu D, Mehdipour AR, Hards K, Harold LK, Radloff M, Stewart I, Welsch S, Hummer G, Cook GM, Krause KL, Michel H
Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells.
1. Mol Cell - published September 2, 2021
2. Donohoue PD, Pacesa M, Lau E, Vidal B, Irby MJ, Nyer DB, Rotstein T, Banh L, Toh MS, Gibson J, Kohrs B, Baek K, Owen ALG, Slorach EM, van Overbeek M, Fuller CK, May AP, Jinek M, Cameron P
SUV39 SET domains mediate crosstalk of heterochromatic histone marks.
1. Elife - published September 1, 2021
2. Stirpe A, Guidotti N, Northall SJ, Kilic S, Hainard A, Vadas O, Fierz B, Schalch T
Global Proximity Interactome of the Human Macroautophagy Pathway.
1. Autophagy - published September 1, 2021
2. Tu YXI, Sydor AM, Coyaud E, Laurent EMN, Dyer D, Mellouk N, St-Germain J, Vernon RM, Forman-Kay JD, Li T, Hua R, Zhao K, Ridgway ND, Kim PK, Raught B, Brumell JH
Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains.
1. Nat Commun - published September 1, 2021
2. Deneka D, Rutz S, Hutter CAJ, Seeger MA, Sawicka M, Dutzler R
An engineered IL-2 partial agonist promotes CD8⁺ T cell stemness.
1. Nature - published September 1, 2021
2. Mo F, Yu Z, Li P, Oh J, Spolski R, Zhao L, Glassman CR, Yamamoto TN, Chen Y, Golebiowski FM, Hermans D, Majri-Morrison S, Picton LK, Liao W, Ren M, Zhuang X, Mitra S, Lin JX, Gattinoni L, Powell JD, Restifo NP, Garcia KC, Leonard WJ
Advances in TRP channel drug discovery: from target validation to clinical studies.
1. Nat Rev Drug Discov - published September 1, 2021
2. Koivisto AP, Belvisi MG, Gaudet R, Szallasi A
Identifying digenic disease genes via machine learning in the Undiagnosed Diseases Network.
1. Am J Hum Genet - published September 1, 2021
2. Mukherjee S, Cogan JD, Newman JH, Phillips JA 3rd, Hamid R, Undiagnosed Diseases Network., Meiler J, Capra JA
Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites.
1. Cell Chem Biol - published September 1, 2021
2. Lee JH, Mosher EP, Lee YS, Bumpus NN, Berger JM
Synthesis of Oligoribonucleotides Containing a 2'-Amino-5'-S-phosphorothiolate Linkage.
1. J Org Chem - published September 1, 2021
2. Li NS, Koo SC, Piccirilli JA
Structural characterization of NrnC identifies unifying features of dinucleotidases.
1. Elife - published September 1, 2021
2. Lormand JD, Kim SK, Walters-Marrah GA, Brownfield BA, Fromme JC, Winkler WC, Goodson JR, Lee VT, Sondermann H
Measuring in vivo protein turnover and exchange in yeast macromolecular assemblies.
1. STAR Protoc - published September 1, 2021
2. Hakhverdyan Z, Molloy KR, Subbotin RI, Fernandez-Martinez J, Chait BT, Rout MP
HOW TIM PROTEINS DIFFERENTIALLY EXPLOIT MEMBRANE FEATURES TO ATTAIN ROBUST TARGET SENSITIVITY.
1. Biophys J - published September 1, 2021
2. Kerr D, Gong Z, Suwatthee T, Luoma A, Roy S, Scarpaci R, Hwang HL, Henderson JM, Cao KD, Bu W, Lin B, Tietjen GT, Steck TL, Adams EJ, Lee KYC
The biological and clinical significance of emerging SARS-CoV-2 variants.
1. Nat Rev Genet - published September 1, 2021
2. Tao K, Tzou PL, Nouhin J, Gupta RK, de Oliveira T, Kosakovsky Pond SL, Fera D, Shafer RW
Oncogenic truncations of ASXL1 enhance a motif for BRD4 ET-domain binding.
1. J Mol Biol - published September 1, 2021
2. Burgess AE, Kleffmann T, Mace PD
Characteristics and operation outcomes of neuro-oncology patients after COVID-19 pandemic - A case series.
1. Interdiscip Neurosurg - published September 1, 2021
2. Zou Y, Zhang J, Zhang T, Feng Y, Xiong Z, Xu C, Gong P, Si J, Chen J
Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species.
1. Cell Metab - published September 1, 2021
2. Zhang XJ, Liu X, Hu M, Zhao GJ, Sun D, Cheng X, Xiang H, Huang YP, Tian RF, Shen LJ, Ma JP, Wang HP, Tian S, Gan S, Xu H, Liao R, Zou T, Ji YX, Zhang P, Cai J, Wang ZV, Meng G, Xu Q, Wang Y, Ma XL, Liu PP, Huang Z, Zhu L, She ZG, Zhang X, Bai L, Yang H, Lu Z, Li H
Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA and monitors genome integrity.
1. Life Sci Alliance - published September 1, 2021
2. Mohanty BK, Karam JA, Howley BV, Dalton AC, Grelet S, Dincman T, Streitfeld WS, Yoon JH, Balakrishnan L, Chazin WJ, Long DT, Howe PH
A protocol for qualitative and quantitative measurement of endosomal processing using hot spot analysis.
1. STAR Protoc - published September 1, 2021
2. Clement CC, Nanaware PP, Stern LJ, Santambrogio L
Protocol for the use of focused ion-beam milling to prepare crystalline lamellae for microcrystal electron diffraction (MicroED).
1. STAR Protoc - published September 1, 2021
2. Martynowycz MW, Gonen T
Insights into modular polyketide synthase loops aided by repetitive sequences.
1. Proteins - published September 1, 2021
2. Hirsch M, Kumru K, Desai RR, Fitzgerald BJ, Miyazawa T, Ray KA, Saif N, Spears S, Keatinge-Clay AT
Higher-order assemblies in immune signaling: supramolecular complexes and phase separation.
1. Protein Cell - published September 1, 2021
2. Xia S, Chen Z, Shen C, Fu TM
In situ imaging of bacterial outer membrane projections and associated protein complexes using electron cryo-tomography.
1. Elife - published September 1, 2021
2. Kaplan M, Chreifi G, Metskas LA, Liedtke J, Wood CR, Oikonomou CM, Nicolas WJ, Subramanian P, Zacharoff LA, Wang Y, Chang YW, Beeby M, Dobro M, Zhu Y, McBride M, Briegel A, Shaffer C, Jensen GJ
Rational design of ASCT2 inhibitors using an integrated experimental-computational approach.
1. Proc Natl Acad Sci U S A - published September 1, 2021
2. Garibsingh RA, Ndaru E, Garaeva AA, Shi Y, Zielewicz L, Zakrepine P, Bonomi M, Slotboom DJ, Paulino C, Grewer C, Schlessinger A
The enigmatic Placozoa part 1: Exploring evolutionary controversies and poor ecological knowledge.
1. Bioessays - published September 1, 2021
2. Schierwater B, Osigus HJ, Bergmann T, Blackstone NW, Hadrys H, Hauslage J, Humbert PO, Kamm K, Kvansakul M, Wysocki K, DeSalle R
A design approach for layer-by-layer surface-mediated siRNA delivery.
1. Acta Biomater - published September 1, 2021
2. Chou JJ, Berger AG, Jalili-Firoozinezhad S, Hammond PT
A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects.
1. J Med Chem - published September 1, 2021
2. Chakraborty S, DiBerto JF, Faouzi A, Bernhard SM, Gutridge AM, Ramsey S, Zhou Y, Provasi D, Nuthikattu N, Jilakara R, Nelson MNF, Asher WB, Eans SO, Wilson LL, Chintala SM, Filizola M, van Rijn RM, Margolis EB, Roth BL, McLaughlin JP, Che T, Sames D, Javitch JA, Majumdar S
Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode.
1. Biochemistry - published September 1, 2021
2. Lockbaum GJ, Henes M, Lee JM, Timm J, Nalivaika EA, Thompson PR, Kurt Yilmaz N, Schiffer CA
Rapid prototyping of arbitrary 2D and 3D wireframe DNA origami.
1. Nucleic Acids Res - published September 1, 2021
2. Jun H, Wang X, Parsons MF, Bricker WP, John T, Li S, Jackson S, Chiu W, Bathe M
Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing.
1. Nucleic Acids Res - published September 1, 2021
2. Jahns H, Degaonkar R, Podbevsek P, Gupta S, Bisbe A, Aluri K, Szeto J, Kumar P, LeBlanc S, Racie T, Brown CR, Castoreno A, Guenther DC, Jadhav V, Maier MA, Plavec J, Egli M, Manoharan M, Zlatev I
Structural analysis of receptors and actin polarity in platelet protrusions.
1. Proc Natl Acad Sci U S A - published September 1, 2021
2. Sorrentino S, Conesa JJ, Cuervo A, Melero R, Martins B, Fernandez-Gimenez E, de Isidro-Gomez FP, de la Morena J, Studt JD, Sorzano COS, Eibauer M, Carazo JM, Medalia O
Diphthamide promotes TOR signaling by increasing the translation of proteins in the TORC1 pathway.
1. Proc Natl Acad Sci U S A - published September 1, 2021
2. Zhang Y, Lin Z, Zhu J, Wang M, Lin H
Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade.
1. Proc Natl Acad Sci U S A - published September 1, 2021
2. Qu C, Park JY, Yun MW, He QT, Yang F, Kim K, Ham D, Li RR, Iverson TM, Gurevich VV, Sun JP, Chung KY
Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens.
1. Sci Adv - published September 1, 2021
2. Monteith AJ, Miller JM, Maxwell CN, Chazin WJ, Skaar EP
The molecular mechanism of RIG-I activation and signaling.
1. Immunol Rev - published September 1, 2021
2. Thoresen D, Wang W, Galls D, Guo R, Xu L, Pyle AM
Compendium of Causative Genes and Their Encoded Proteins for Common Monogenic Disorders.
1. Protein Sci - published September 1, 2021
2. Apgar TL, Sanders CR
Characterization of modeled inhibitory binding sites on isoform one of the Na⁺/H⁺ exchanger.
1. Biochim Biophys Acta Biomembr - published September 1, 2021
2. Li X, Kim J, Yang J, Dutta D, Fliegel L
Simultaneous exposure to intracellular and extracellular photosensitizers for the treatment of Staphylococcus aureus infections.
1. Antimicrob Agents Chemother - published September 1, 2021
2. Drury SL, Miller AR, Laut CL, Walter AB, Bennett MR, Su M, Bai M, Jing B, Joseph SB, Metzger EJ, Bane CE, Black CC, Macdonald MT, Dutter BF, Romaine IM, Waterson AG, Sulikowski GA, Jansen ED, Crowe JE Jr, Sciotti RJ, Skaar EP
Magnetic Control and Real-Time Monitoring of Stem Cell Differentiation by the Ligand Nanoassembly.
1. Small - published September 1, 2021
2. Lee S, Kim MS, Patel KD, Choi H, Thangam R, Yoon J, Koo TM, Jung HJ, Min S, Bae G, Kim Y, Han SB, Kang N, Kim M, Li N, Fu HE, Jeon YS, Song JJ, Kim DH, Park S, Choi JW, Paulmurugan R, Kang YC, Lee H, Wei Q, Dravid VP, Lee KB, Kim YK, Kang H
Nucleolar maturation of the human small subunit processome.
1. Science - published September 1, 2021
2. Singh S, Vanden Broeck A, Miller L, Chaker-Margot M, Klinge S
A complete Protocadherin-19 ectodomain model for evaluating epilepsy-causing mutations and potential protein interaction sites.
1. Structure - published September 1, 2021
2. Hudson JD, Tamilselvan E, Sotomayor M, Cooper SR
Computational and biochemical analysis of type IV pilus dynamics and stability.
1. Structure - published September 1, 2021
2. Karami Y, López-Castilla A, Ori A, Thomassin JL, Bardiaux B, Malliavin T, Izadi-Pruneyre N, Francetic O, Nilges M
N-Terminal Modification of Gly-His-tagged Proteins with Azidogluconolactone.
1. Chembiochem - published September 1, 2021
2. Brune KD, Liekniņa I, Sutov G, Morris AR, Jovicevic D, Kalniņš G, Kazāks A, Kluga R, Kastaljana S, Zajakina A, Jansons J, Skrastiņa D, Spunde K, Cohen AA, Bjorkman PJ, Morris HR, Suna E, Tārs K
Lattice micropatterning for cryo-electron tomography studies of cell-cell contacts.
1. J Struct Biol - published September 1, 2021
2. Engel L, Vasquez CG, Montabana EA, Sow BM, Walkiewicz MP, Weis WI, Dunn AR
Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS.
1. Elife - published September 1, 2021
2. Sheedlo MJ, Durie CL, Chung JM, Chang L, Roberts J, Swanson M, Lacy DB, Ohi MD
Inosine Substitutions in RNA Activate Latent G-Quadruplexes.
1. J Am Chem Soc - published September 1, 2021
2. Hagen T, Laski A, Brümmer A, Pruška A, Schlösser V, Cléry A, Allain FH, Zenobi R, Bergmann S, Hall J
Distinctive Roles of Two Acinetobactin Isomers in Challenging Host Nutritional Immunity.
1. mBio - published September 1, 2021
2. Kim M, Kim DY, Song WY, Park SE, Harrison SA, Chazin WJ, Oh MH, Kim HJ
Trypanosoma brucei Tim50 Possesses PAP Activity and Plays a Critical Role in Cell Cycle Regulation and Parasite Infectivity.
1. mBio - published September 1, 2021
2. Tripathi A, Singha UK, Cooley A, Gillyard T, Krystofiak E, Pratap S, Davis J, Chaudhuri M