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63 Member Publications for August

Previous Month

A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade.
1. Nat Commun - published August 9, 2019
2. Zheng Y, Qiu Y, Grace CRR, Liu X, Klionsky DJ, Schulman BA
Cryo-EM structure of the native rhodopsin dimer in nanodiscs.
1. J Biol Chem - published August 9, 2019
2. Zhao DY, Poege M, Morizumi T, Gulati S, Van Eps N, Zhang J, Miszta P, Filipek S, Mahamid J, Plitzko JM, Baumeister W, Ernst OP, Palczewski K
Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.
1. Elife - published August 9, 2019
2. Knott GJ, Cress BF, Liu JJ, Thornton BW, Lew RJ, Al-Shayeb B, Rosenberg DJ, Hammel M, Adler BA, Lobba MJ, Xu M, Arkin AP, Fellmann C, Doudna JA
A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites.
1. Nat Commun - published August 9, 2019
2. Koirala D, Shao Y, Koldobskaya Y, Fuller JR, Watkins AM, Shelke SA, Pilipenko EV, Das R, Rice PA, Piccirilli JA
In Vitro Assessment of Putative PD-1/PD-L1 Inhibitors: Suggestions of an Alternative Mode of Action.
1. ACS Med Chem Lett - published August 8, 2019
2. Blevins DJ, Hanley R, Bolduc T, Powell DA, Gignac M, Walker K, Carr MD, Hof F, Wulff JE
Manipulation by Methylation: Garnishing mRNAs with m6Am.
1. Mol Cell - published August 8, 2019
2. Doxtader KA, Nam Y
Dynamic regulatory features of the protein tyrosine kinases.
1. Biochem Soc Trans - published August 8, 2019
2. Amatya N, Lin DY, Andreotti AH
Strain-dependent Activation and Inhibition of Human Immunodeficiency Virus (HIV-1) Entry by a Specific PF-68742 Stereoisomer.
1. J Virol - published August 7, 2019
2. Zhao C, Princiotto AM, Nguyen HT, Zou S, Zhao ML, Zhang S, Herschhorn A, Farrell M, Pahil K, Melillo B, Sambasivarao SV, Abrams C, Smith AB 3rd, Madani N, Sodroski J
Aspartate Residues Far from the Active Site Drive O-GlcNAc Transferase Substrate Selection.
1. J Am Chem Soc - published August 7, 2019
2. Joiner CM, Levine ZG, Aonbangkhen C, Woo CM, Walker S
Opposing T cell responses in experimental autoimmune encephalomyelitis.
1. Nature - published August 7, 2019
2. Saligrama N, Zhao F, Sikora MJ, Serratelli WS, Fernandes RA, Louis DM, Yao W, Ji X, Idoyaga J, Mahajan VB, Steinmetz LM, Chien YH, Hauser SL, Oksenberg JR, Garcia KC, Davis MM
The structure of a highly conserved picocyanobacterial protein reveals a Tudor domain with an RNA binding function.
1. J Biol Chem - published August 7, 2019
2. Bauer KM, Dicovitsky R, Pellegrini M, Zhaxybayeva O, Ragusa MJ
Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2.
1. Biochemistry - published August 6, 2019
2. Srivastava D, Nandi S, Dey M
Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export.
1. Nat Commun - published August 6, 2019
2. Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomès R, Privé GG, Annaert W, Schwake M, Heeren J, Lüllmann-Rauch R, Grinstein S, Ikonen E, Saftig P, Neculai D
A strategy for the selection of monovalent antibodies that span protein dimer interfaces.
1. J Biol Chem - published August 6, 2019
2. Spangler JB, Moraga I, Jude KM, Savvides CS, Garcia KC
Neuregulin Signaling is a Mechanism of Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma.
1. Mol Cancer Ther - published August 6, 2019
2. Baro M, Lopez Sambrooks C, Burtness BA, Lemmon MA, Contessa JN
Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis.
1. Structure - published August 6, 2019
2. Zhou Y, Millott R, Kim HJ, Peng S, Edwards RA, Skene-Arnold T, Hammel M, Lees-Miller SP, Tainer JA, Holmes CFB, Glover JNM
Structural Basis for the Differential Regulatory Roles of the PDZ Domain in C-Terminal Processing Proteases.
1. MBio - published August 6, 2019
2. Chueh CK, Som N, Ke LC, Ho MR, Reddy M, Chang CI
The Molecular Function of σ Receptors: Past, Present, and Future.
1. Trends Pharmacol Sci - published August 3, 2019
2. Schmidt HR, Kruse AC
The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10.
1. Open Biol - published August 3, 2019
2. Paulson CN, John K, Baxley RM, Kurniawan F, Orellana K, Francis R, Sobeck A, Eichman BF, Chazin WJ, Aihara H, Georg GI, Hawkinson JE, Bielinsky AK
Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose dehydratase.
1. J Biol Chem - published August 2, 2019
2. Eisemann T, Langelier MF, Pascal JM
Carboxyboronate: A Versatile C1-Building Block.
1. Angew Chem Int Ed Engl - published August 2, 2019
2. Yudin AK, Holownia A, Tien CH, Diaz DB, Larson RT
Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence.
1. Elife - published August 2, 2019
2. Yu L, O'Brien VP, Livny J, Dorsey D, Bandyopadhyay N, Colonna M, Caparon MG, Roberson ED, Hultgren SJ, Hannan TJ
Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA.
1. Nucleic Acids Res - published August 2, 2019
2. Solomon WC, Myint W, Hou S, Kanai T, Tripathi R, Kurt Yilmaz N, Schiffer CA, Matsuo H
Roles of HIFs and VEGF in angiogenesis in the retina and brain.
1. J Clin Invest - published August 1, 2019
2. Rattner A, Williams J, Nathans J
Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
1. ACS Chem Biol - published August 1, 2019
2. Henes M, Lockbaum GJ, Kosovrasti K, Leidner F, Nachum GS, Nalivaika EA, Lee SK, Spielvogel E, Zhou S, Swanstrom R, Bolon DNA, Kurt Yilmaz N, Schiffer CA
Structural characterization of Class 2 OLD family nucleases supports a two-metal catalysis mechanism for cleavage.
1. Nucleic Acids Res - published August 1, 2019
2. Schiltz CJ, Lee A, Partlow EA, Hosford CJ, Chappie JS
Direction of Chain Growth and Substrate Preferences of Shape, Elongation, Division, and Sporulation-Family Peptidoglycan Glycosyltransferases.
1. J Am Chem Soc - published August 1, 2019
2. Welsh MA, Schaefer K, Taguchi A, Kahne D, Walker S
Conformational Control of Macrocycles by Remote Structural Modification.
1. Chem Rev - published August 1, 2019
2. Appavoo SD, Huh S, Diaz DB, Yudin AK
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.
1. Sci Transl Med - published August 1, 2019
2. Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, Li Z, Del-Aguila JL, Dube U, Farias FG, Bradley J, Budde J, Ibanez L, Fernandez MV, Blennow K, Zetterberg H, Heslegrave A, Johansson PM, Svensson J, Nellgård B, Lleo A, Alcolea D, Clarimon J, Rami L, Molinuevo JL, Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Ewers M, Harari O, Haass C, Brett TJ, Benitez BA, Karch CM, Piccio L, Cruchaga C
Localized Electronic Structure of Nitrogenase FeMoco Revealed by Selenium K-Edge High Resolution X-ray Absorption Spectroscopy.
1. J Am Chem Soc - published August 1, 2019
2. Henthorn JT, Arias RJ, Koroidov S, Kroll T, Sokaras D, Bergmann U, Rees DC, DeBeer S
Ega3 from the fungal pathogen Aspergillus fumigatus is an endo-α-1,4-galactosaminidase that disrupts microbialbiofilms.
1. J Biol Chem - published August 1, 2019
2. Bamford NC, Le Mauff F, Subramanian AS, Yip P, Millán C, Zhang Y, Zacharias C, Forman A, Nitz M, Codée JDC, Usón I, Sheppard DC, Howell PL
Radiological and clinical predictors of scoliosis in patients with Chiari malformation type I and spinal cord syrinx from the Park-Reeves Syringomyelia Research Consortium.
1. J Neurosurg Pediatr - published August 1, 2019
2. Strahle JM, Taiwo R, Averill C, Torner J, Shannon CN, Bonfield CM, Tuite GF, Bethel-Anderson T, Rutlin J, Brockmeyer DL, Wellons JC, Leonard JR, Mangano FT, Johnston JM, Shah MN, Iskandar BJ, Tyler-Kabara EC, Daniels DJ, Jackson EM, Grant GA, Couture DE, Adelson PD, Alden TD, Aldana PR, Anderson RCE, Selden NR, Baird LC, Bierbrauer K, Chern JJ, Whitehead WE, Ellenbogen RG, Fuchs HE, Guillaume DJ, Hankinson TC, Iantosca MR, Oakes WJ, Keating RF, Khan NR, Muhlbauer MS, McComb JG, Menezes AH, Ragheb J, Smith JL, Maher CO, Greene S, Kelly M, O'Neill BR, Krieger MD, Tamber M, Durham SR, Olavarria G, Stone SSD, Kaufman BA, Heuer GG, Bauer DF, Albert G, Greenfield JP, Wait SD, Van Poppel MD, Eskandari R, Mapstone T, Shimony JS, Dacey RG, Smyth MD, Park TS, Limbrick DD
Conformationally stable peptide macrocycles assembled using the Petasis borono-Mannich reaction.
1. Chem Commun (Camb) - published August 1, 2019
2. Yamaguchi A, Kaldas SJ, Appavoo SD, Diaz DB, Yudin AK
Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways.
1. J Cell Biol - published August 1, 2019
2. Azoitei ML, Noh J, Marston DJ, Roudot P, Marshall CB, Daugird TA, Lisanza SL, Sandí MJ, Ikura M, Sondek J, Rottapel R, Hahn KM, Danuser G
Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints.
1. J Chem Inf Model - published August 1, 2019
2. Leidner F, Kurt Yilmaz N, Schiffer CA
Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED.
1. Structure - published August 1, 2019
2. Martynowycz MW, Zhao W, Hattne J, Jensen GJ, Gonen T
The impact of electrical injuries on long-term outcomes: A Burn Model System National Database study.
1. Burns - published August 1, 2019
2. Or S, Aw W, Lf E, Lc S, K K, Gj C, N G, Am B, W M, M R, L R, LE K, Cm R, Jc S
Ca2+-regulated Ca2+ channels with an RCK gating ring control plant symbiotic associations.
1. Nat Commun - published August 1, 2019
2. Kim S, Zeng W, Bernard S, Liao J, Venkateshwaran M, Ane JM, Jiang Y
Structure of the Centromere Binding Factor 3 Complex from Kluyveromyces lactis.
1. J Mol Biol - published August 1, 2019
2. Lee PD, Wei H, Tan D, Harrison SC
Tracking RNA with light: selection, structure, and design of fluorescence turn-on RNA aptamers.
1. Q Rev Biophys - published August 1, 2019
2. Trachman RJ, Ferré-D'Amaré AR
Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice.
1. Nat Biotechnol - published August 1, 2019
2. Mourtada R, Herce HD, Yin DJ, Moroco JA, Wales TE, Engen JR, Walensky LD
Co-crystal structure of the iMango-III fluorescent RNA aptamer using an X-ray free-electron laser.
1. Acta Crystallogr F Struct Biol Commun - published August 1, 2019
2. Trachman RJ 3rd, Stagno JR, Conrad C, Jones CP, Fischer P, Meents A, Wang YX, Ferré-D'Amaré AR
Crystal structure of the Schizosaccharomyces pombe U7BR E2-binding region in complex with Ubc7.
1. Acta Crystallogr F Struct Biol Commun - published August 1, 2019
2. Hann ZS, Metzger MB, Weissman AM, Lima CD
Inhibition of AKT signalling by benzoxazine derivative LTUR6 through the modulation of downstream kinases.
1. Invest New Drugs - published August 1, 2019
2. Suraj R, Al-Rawi J, Bradley C
Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases.
1. Nat Chem Biol - published August 1, 2019
2. Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE
The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.
1. Nat Struct Mol Biol - published August 1, 2019
2. Batki J, Schnabl J, Wang J, Handler D, Andreev VI, Stieger CE, Novatchkova M, Lampersberger L, Kauneckaite K, Xie W, Mechtler K, Patel DJ, Brennecke J
The Novel Interaction Between Neisseria gonorrhoeae TdfJ and Human S100A7 Allows Gonococci to Subvert Host Zinc Restriction.
1. PLoS Pathog - published August 1, 2019
2. Maurakis S, Keller K, Maxwell CN, Pereira K, Chazin WJ, Criss AK, Cornelissen CN
Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome.
1. Bone - published August 1, 2019
2. Gordon CM, Cleveland RH, Baltrusaitis K, Massaro J, D'Agostino RB Sr, Liang MG, Snyder B, Walters M, Li X, Braddock DT, Kleinman ME, Kieran MW, Gordon LB
EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer.
1. Mol Cancer Ther - published August 1, 2019
2. Viswanadhapalli S, Luo Y, Sareddy GR, Santhamma B, Zhou M, Li M, Ma S, Sonavane R, Pratap UP, Altwegg KA, Li X, Chang A, Chávez-Riveros A, Dileep KV, Zhang KYJ, Pan X, Murali R, Bajda M, Raj GV, Brenner AJ, Manthati V, Rao MK, Tekmal RR, Nair HB, Nickisch KJ, Vadlamudi RK
Targeted delivery and endosomal cellular uptake of DARPin-siRNA bioconjugates: Influence of linker stability on gene silencing.
1. Eur J Pharm Biopharm - published August 1, 2019
2. Lorenzer C, Streußnig S, Tot E, Winkler AM, Merten H, Brandl F, Sayers EJ, Watson P, Jones AT, Zangemeister-Wittke U, Plückthun A, Winkler J
Comparison of structural progression between ciliopathy and non-ciliopathy associated with autosomal recessive retinitis pigmentosa.
1. Orphanet J Rare Dis - published August 1, 2019
2. Takahashi VKL, Xu CL, Takiuti JT, Apatoff MBL, Duong JK, Mahajan VB, Tsang SH
Ligand retargeting by binding site analogy.
1. Eur J Med Chem - published August 1, 2019
2. Wiedmer L, Schärer C, Spiliotopoulos D, Hürzeler M, Śledź P, Caflisch A
Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations.
1. Nat Commun - published August 1, 2019
2. de Wispelaere M, Du G, Donovan KA, Zhang T, Eleuteri NA, Yuan JC, Kalabathula J, Nowak RP, Fischer ES, Gray NS, Yang PL
CRISPR Tools for Systematic Studies of RNA Regulation.
1. Cold Spring Harb Perspect Biol - published August 1, 2019
2. Engreitz J, Abudayyeh O, Gootenberg J, Zhang F
Open and cut: allosteric motion and membrane fission by dynamin superfamily proteins.
1. Mol Biol Cell - published August 1, 2019
2. Kalia R, Frost A
Disruption of IRE1α through its kinase domain attenuates multiple myeloma.
1. Proc Natl Acad Sci U S A - published August 1, 2019
2. Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen YA, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, Clark K, Kaufman S, Beresini MH, Laing ST, Sandoval W, Lorenzo M, Wu J, Ly J, De Bruyn T, Heidersbach A, Haley B, Gogineni A, Weimer RM, Lee D, Braun MG, Rudolph J, VanWyngarden MJ, Sherbenou DW, Gomez-Bougie P, Amiot M, Acosta-Alvear D, Walter P, Ashkenazi A
An evolutionary perspective on the first disulfide bond in members of the cholinesterase-carboxylesterase (COesterase) family: Possible outcomes for cholinesterase expression in prokaryotes.
1. Chem Biol Interact - published August 1, 2019
2. Chatonnet A, Brazzolotto X, Hotelier T, Lenfant N, Marchot P, Bourne Y
20-HETE synthesis inhibition promotes cerebral protection after intracerebral hemorrhage without inhibiting angiogenesis.
1. J Cereb Blood Flow Metab - published August 1, 2019
2. Han X, Zhao X, Lan X, Li Q, Gao Y, Liu X, Wan J, Yang Z, Chen X, Zang W, Guo AM, Falck JR, Koehler RC, Wang J
Introduction to a special issue on Frontiers of Aberration Corrected Electron Microscopy in honour of Christian Colliex, Archie Howie and Hannes Lichte on the occasion of their 75th, 85th and 75th birthdays.
1. Ultramicroscopy - published August 1, 2019
2. Dunin-Borkowski RE, Mayer J, Sachse C, Tillmann K
Structural characterization of the human membrane protein VDAC2 in lipid bilayers by MAS NMR.
1. J Biomol NMR - published August 1, 2019
2. Eddy MT, Yu TY, Wagner G, Griffin RG
A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary CaVβ subunits.
1. Elife - published August 1, 2019
2. Morgenstern T, Park J, Fan QR, Colecraft HM
Structure and chemistry of lysinoalanine crosslinking in the spirochaete flagella hook.
1. Nat Chem Biol - published August 1, 2019
2. Lynch MJ, Miller M, James M, Zhang S, Zhang K, Li C, Charon NW, Crane BR
CAPN5 genetic inactivation phenotype supports therapeutic inhibition trials.
1. Hum Mutat - published August 1, 2019
2. Wert KJ, Koch SF, Velez G, Hsu CW, Mahajan M, Bassuk AG, Tsang SH, Mahajan VB