The evolution of SBGrid tracks with advances in structural biology, and cryo-EM is at the forefront of that change. This article reflects on 3 pivotal papers that describe key advances in cryoEM, from member laboratories and software contributors who were early participants in SBGrid. Read the full story.
Image caption: A clathrin cage with a single triskelion highlighted in blue. CryoEM map EMD_5119 was rendered in UCSF Chimera and one clathrin triskelion was highlighted. Image courtesy of Mazuraan CC BY-SA 4.0 license.
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Join us for our monthly live webinar series in which we feature contributing developers demonstrating their software, highlighting new features, and previewing future developments. You'll hear the latest news and have opportunity to ask questions directly relevant to your research. Be sure to subscribe to SBGridTV to receive alerts when we post new recordings and view our full collection of past tutorials.
Up next: ISOLDE
September 24th at 12pm EDT
ISOLDE: Bringing structural biology to life
Tristan Croll
Research Fellow
University of Cambridge
Building high-quality macromolecular models into medium-low density maps (i.e. >2.5Å resolution) has historically been extremely challenging. In the absence of higher-resolution reference models, high rates of residual error in existing low-resolution models are the norm rather than the exception. ISOLDE (https://isolde ...
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Join us on May 22nd to hear from Giovanni Bussi from SISSA, Trieste and Massimiliano Bonomi, from the University of Cambridge, on Analyzing and enhancing molecular dynamics simulations with PLUMED.
Analyzing and enhancing molecular dynamics simulations with PLUMED
Tuesday, May 22nd at 12:00pm EDT
Giovanni Bussi -- Associate Professor, SISSA, Trieste, Italy
Massimiliano Bonomi -- Postdoc, University of Cambridge, Vendruscolo Group
Host: Jason Key
For more information on PLUMED, visit the website http://www.plumed.org/, browse the manual, check out Github: http://github.com/plumed, and read these publications:
- PLUMED: A portable plugin for free-energy calculations with molecular dynamics. [Abstract] (arxiv.org/abs/0902.0874)
- PLUMED 2: New feathers for an old bird. [Abstract] (arxiv.org/abs/1310.0980)
Webinar connection instructions: We are now using BlueJeans to ...
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Join us on November 14th to hear about the latest updates to EMAN2.2 from Baylor College of Medicine Professor, Steven Ludtke.
- EMAN2.2 for Single Particle Analysis and In-situ Structural Biology
Tuesday, November 14th at 12:00pm EST
Steven Ludtke, Ph.D.
Professor of Biochemistry - Baylor College of Medicine
Co-Director - National Center for Macromolecular Imaging
Co-Director - Center for Computational and Integrative Biomedical Research
EMAN2 has undergone dramatic changes in the last year, both in expanding its capabilities to in-situ (CryoET) segmentation and high-resolution high-speed subtomogram averaging, as well as with traditional single particle analysis. New deep-learning technology in EMAN2 permits automatic segmentation of cellular tomograms as well as highly accurate particle picking in single particle analysis. Even more recently, a novel computational approach based on robust invariants ...
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Our position postings page advertises open positions for postdocs, students, faculty, and staff in SBGrid member laboratories and institutions. Please send brief descriptions to Michelle. Postings will remain online for 60 days
SBGrid Advanced Research Computing Team
Harvard Medical School, Dept of Biological Chemistry and Molecular Pharmacology
Senior Research Computing Scientist: The structural biology Advanced Research Computing (ARC) team at SBGrid / Harvard Medical School has a position opening for a Senior Research Computing Scientist. The ARC team designs, implements, and maintains a specialized computing infrastructure to support all phases of macromolecular structure determination via CryoEM, X-ray Crystallography, and NMR. The infrastructure includes storage to support data acquisition as well as Linux workstations and OSX research desktops for data processing. We also support computational clusters and specialized research instrumentation ...
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