Our position postings page advertises open positions for postdocs, students, faculty, and staff in SBGrid member laboratories and institutions. Please send brief descriptions to Michelle. Postings will remain online for 60 days
Cryo-EM Specialist
Harvard Cryo-EM Center for Structural Biology
Harvard Medical School houses two core facilities providing access to negative stain and cryo-EM instrumentation; we are looking for a highly motivated scientist to join our team. The Harvard Cryo-EM Center for Structural Biology, formed as a consortium between HMS, Boston Children's Hospital, Dana-Farber Cancer Institute, and Massachusetts General Hospital, serves the consortium members and a variety of external academic and commercial users. The Molecular Electron Microscopy Suite is a training resource for Quad-based researchers at Harvard Medical School. The successful candidate will provide support and training for researchers seeking to learn cryo-EM and negative-stain EM in these two facilities, serving as an interface between the instrumentation and a vibrant scientific community. The candidate will work closely with a team of scientists to support COVID-19 and related projects in many research areas and will take on facility management responsibilities.
Key Roles:
- Serve as the technical interface between users and the Talos Arctica and Titan Krios microscopes by loading samples and checking microscope alignments.
- Train users to operate TEM microscopes, specifically the Tecnai T12, Talos Arctica, and Titan Krios; including sample preparation (negative stain and cryo-plunging), grid loading, sample screening, and data collection.
- Advise researchers on experimental strategy and, when appropriate, collaborate with them to assist in data acquisition, analysis and structure determination, particularly with COVID-19-related work.
- Interact closely with the core facilities’ team to manage microscope and equipment maintenance, coordinate user scheduling and training, and interface with SBGrid to assist with the computational needs of both facilities.
- This position will have a high degree of independence, opportunities to present at regional and national scientific symposia and workshops, and opportunities to develop collaborative relationships with Harvard community investigators.
Posting Date Aug 31, 2020
Computational Scientist
Sanofi - Protein Engineering Group, Large Molecule Research Department
The Protein Engineering group within Sanofi Large Molecule Research Department is seeking a highly talented Computational Scientist for a postdoctoral position. We use leading-edge structural biology and computational tools to support biologics project needs from Sanofi’s multi-targeting, multi-modality research pipeline. Our team has a great track record of patents and publications, including Science, Nature Cancer, and Nature Communications, in the area of biologics characterization, antibody engineering and multi-specific antibodies. This postdoc project will focus on developing a machine learning approach to predict epitope-paratope, given any antibody-antigen pair, by combining in-depth understanding of structure biology, antibody engineering, and large datasets both internally and externally. The successful candidate will be with Ph. D. degree in related area and has an advanced understanding and practical experience with developing and applying complex machine learning solutions for structural biology data. The successful candidate will gain deeper insight into drug development process and transform AI/ML algorithms into accelerating biologics discovery and development process.
About Sanofi: Every day, Sanofi's 100,000 employees are committed to improve the lives of people around the world, with sustainable and responsible solutions and initiatives. Sanofi is recognized as one of the leading biopharmaceutical companies in the world and is pioneering innovation in biologics with the first approved nanobody drug, the first clinical stage tri-specific antibody, and a novel genetic codon expansion platform for new engineering capabilities. Details of the organization and the company’s mission and goals can be found on our website (http://www.sanofi.us/l/us/en/index.jsp).
Posting Date Aug 6, 2020
Postdoctoral Position
Brown University, USA, Deaconescu Lab
The Deaconescu Lab at Brown University has one opening for a postdoctoral researcher. The laboratory's interests lie primarily in stress responses, with particular emphasis on responses to DNA damage and the mechanochemistry of DNA-based motors. We utilize a combination of biochemical, biophysical and structural techniques. (e.g. X-ray crystallography, small-angle X-ray scattering, transmission electron microscopy). Examples of work are: Brugger et al, Nature Communications (2020), Dorich et al, Genes & Development (2019), Vemu et al. Science (2018), Le TT et al. Cell (2018), Deaconescu et al. Photochemistry and Photobiology (2017), Kutter et al. JMB (2016), Szyk et al, Cell (2014), Deaconescu et al., PNAS (2012), Szyk et al., NSMB (2012) and Deaconescu et al., TIBS (2013) and Deaconescu et al., Cell (2006).
A successful candidate should have an established track-record of publications in peer-reviewed journals; solid experience with protein biochemistry (including their purification from E.coli/yeast, functional characterization and assay development). Prior knowledge of crystallography and/or single-particle electron microscopy is highly desirable. Must be highly motivated and work independently as well as in a team. Excellent spoken and written English are required. New Ph.D. graduates are encouraged to apply. Interested candidates should send a CV, a one page research experience summary and contact information for three references to alexandra_deaconescu[at]brown.edu. Please use “postdoctoral candidate” as a subject. Salary and starting date are negotiable.
Brown University, an Ivy League school, is located in Providence, Rhode Island less than one hour away by train from Boston. Rhode Island provides plenty of opportunities for outdoor recreation with beautiful beaches and sailing. Lab webpage: https://deaconesculab.com
Posting Date: Aug 6, 2020