Our position postings page advertises open positions for postdocs, students, faculty, and staff in SBGrid member laboratories and institutions. Please send brief descriptions to Michelle. Postings will remain online for 60 days
Staff Scientist – Structural Biology
Center for Structural Biology, Vanderbilt University
The Center for Structural Biology (CSB) at Vanderbilt University is seeking a full-time Staff Scientist to support high performance computing and storage needs for CSB investigators. Day to day operations will take place within the Advanced Computing Center for Research and Education (ACCRE). ACCRE is a shared Vanderbilt resource that runs an > 10,000 processor core Linux cluster comprised of multiple architectures and manages over 12 petabytes of parallel access, fault tolerant, distributed disk storage.
This position will focus on optimizing software installs, data management, scripting, and user support for the CSB research community in order to streamline workflows that utilize Vanderbilt’s growing HPC and data storage facilities. This environment provides the opportunity for a motivated individual to participate in and contribute significantly to a stimulating professional research and teaching environment at the cutting edge of structural biology and high performance computing. This position requires coordination with other scientists within ACCRE and the CSB. The CSB is a multi-disciplinary, trans-institutional center based in the Vanderbilt School of Medicine's Basic Sciences. It supports the technology required for elucidating the atomic structures of biomolecules and biomolecular assemblies: EPR and NMR spectroscopy, X-ray crystallography, Molecular Dynamics and Monte Carlo/Rosetta Modeling, and both Cryo-Electron Microscopy (cryo-EM) and Cryo-Electron Tomography (cryo-ET). The recent and planned expansion of the cryo-EM/cryo-ET facility, along with ongoing developments in computational modeling, have catalyzed the need for dedicated high-end computational support. Full Details Here
Posting Date March 31, 2021
Postdoc – Structural Biology of Genome Regulation
Panne Group, University of Leicester
The University of Leicester is home to the Leicester Institute for Structural and Chemical Biology (LISCB; https://le.ac.uk/liscb ) as a centre of research excellence. Research within LISCB targets the functioning of biological relevant molecules through integrated structural biology approaches including CryoEM, chemistry and functional studies. The Panne group focuses on signal processing on enhancers and how 3D genome organisation contributes to various aspects of genome function.
The successful candidate should have a background in Biochemistry, Biophysics or Molecular Biology. They must have a track record in conducting internationally competitive research, including peer-reviewed publications. We are looking for a creative and ambitious person with good communication skills and keen to work on challenging projects. Experience in biochemistry of protein complexes, insect cell expression systems, X-ray crystallography or cryo-electron microscopy would be particularly beneficial. The group is part of the Leicester Institute of Structural and Chemical Biology one of five flagship research institutes recently established by the University of Leicester, UK. We have excellent access to state-of-the-art structural biology technologies including a Krios cryo-EM microscope equipped with Falcon 3EC and GATAN K3 detectors as well the Diamond and ESRF Synchrotrons. This post is funded by the Wellcome Trust for up to 5 years. You can find out more about this vacancy by contacting daniel.panne@le.ac.uk Full details here: https://jobs.le.ac.uk/vacancies/2872/research-associate-structural-biology-of- genome-regulation.html
Posting Date March 8, 2021
Postdoc – Structural and functional analyses of ubiquitin ligase complexes
Sonja Lorenz's Group, Max Planck Institute for Biophysical Chemistry
The Lorenz laboratory aims to understand how ubiquitin − a single, small protein − achieves specificity in regulating virtually all aspects of eukaryotic cell biology. A major key lies in the action of ubiquitin ligases, the most diversified class of enzymes of the ubiquitination machinery. The immense potential of ubiquitin ligases as therapeutic targets is illustrated by the clinical efficacy of thalidomide and derivatives in the treatment of hematologic malignancies. However, progress towards manipulating ubiquitin ligases rationally has been impeded largely by our insufficient understanding of their structural underpinnings and functional integration into cellular pathways.
The Lorenz lab has establied dedicated tools to capture dynamic macromolecular complexes of ubiquitination enzymes and decipher the molecular basis of their specificities in substrate recognition and ubiquitin linkage formation. We combine chemical-biological, biochemical, cell biological, and structural approaches with a particular focus on exploiting the power of cryo-electron microscopy to resolve large macromolecular assemblies.
We have a fully funded postdoc position available for a talented individual to explore critical ubiquitin ligase complexes in infectious disease or tumor biology.
Qualifications
- You have a PhD or equivalent degree in a relevant subject area, such as structural biology, biochemistry or biophysics. - You have a proven track record and experience in cryo-EM and recombinant protein preparation, ideally using the baculovirus expression system. - Additional experience in X-ray crystallography would be beneficial. - You are curiosity-driven and passionate about science, and not afraid of tackling challenging protein complexes. - You are self-motivated and independent, and enjoy being part of an international and multidisciplinary work environment.Full details here: https://www.mpibpc.mpg.de/17641630/04-21R
Posting Date February 8, 2021