Our job postings page advertises open positions for postdocs, students, faculty, and staff in SBGrid member laboratories and institutions. Please send brief descriptions to Michelle. Postings will remain online for 60 days.
Harvard Medical School
Harvard Medical School has an opening for an Electron Microscopy IT Coordinator
The Electron Microscopy IT Coordinator will be responsible for comprehensive support of all aspects of electron microscopy computations. The coordinator will: Design, implement and support electron microscopy IT resources, including small computing clusters, computational workstations, GPU farms, storage, and data archives.; Monitor and maintain data collection computers. Facilitate and coordinate access to external resources, including campus, national and/or commercial storage and compute systems, when appropriate. ;Direct EM data management efforts, including the management of data transfers between microscopes and storage elements, deployment of data management infrastructure (e.g. dataverse), and development of data management policies, including audits.; Engage with the SBGrid Consortium to maintain an up-to-date library of electron microscopy research software applications that is optimized to run on local resources. ; Test, validate and bench new electron microscopy software releases.; Support local users with all aspects of computations, including data collection, data management, structure determination, and data deposition.; Support research computing outreach, including maintenance of best-practice documentation, organization of computing workshops, and new user orientations.; The position will depend heavily on coordination with the SBGrid Team at Harvard Medical School, particularly for infrastructure design, software support, and development of best-practice recommendations. A strong team player who will collaborate to develop an efficient and productive computing infrastructure is essential.
Preferred Qualifications: PhD in Structural Biology, 2-3 years of research computing experience and at least 1 year of experience with electron microscopy. The successful candidate will have excellent organizational skills and proven project and/or program management skills. Excellent interpersonal and communications skills. Ability to work with discretion.
Technical qualifications: Understanding of python or other programming languages; understanding of structural biology applications (e.g. EMAN, Chimera, Relion, Frealign, or SPIDER) and structure determination/analysis workflows; strong knowledge of Linux and OSX operating systems.
SBGrid teams at Harvard Medical School support all aspect of electron microscopy computations through an international software support network (SBGrid.org) and a Boston-area structural biology research collaborative.
The Harvard EM IT Coordinator will be embedded within the Harvard Medical School Electron Microscopy Center, which is being equipped with new Titan Krios microscopes and will support faculty from Harvard and affiliated institutions, including Boston Children’s Hospital, Dana Farber Cancer Institute, and Massachusetts General Hospital.
For additional information or to apply, please contact SBGrid PI, Dr. Piotr Sliz at email@example.com.
Posting Date: November 6, 2017
POSTDOCTORAL POSITION at Brown University (Structural Biology) The Deaconescu Lab at Brown University is seeking a postdoctoral researcher. The laboratory's interest is the stress response and the interplay between DNA repair and other cellular processes including transcription and chromatin remodeling, and is focused on elucidating the function and mechanochemistry of DNA-based motors using a combination of biochemical, biophysical and structural techniques. (e.g. X-ray crystallography, small-angle X-ray scattering, transmission electron microscopy). For examples of work, please see Deaconescu et al., PNAS (2012), Szyk et al, Cell (2014), Szyk et al., NSMB (2012) and Deaconescu et al., TIBS (2013).
A successful candidate should have the following qualifications: a Ph.D. in the field of Molecular Biology, Cell Biology, Biochemistry or related field; an established track-record of publications in peer-reviewed journals; solid experience in the biochemistry of complex DNA-binding proteins (such as chromatin remodeling factors or DNA repair proteins), their purification from heterologous expression systems as well as their characterization using functional studies such as by isothermal titration calorimetry fluorescence, transcription assays.
Prior knowledge of crystallography is highly desirable. Must be highly motivated and work independently as well as in a team. Excellent spoken and written English are required. New Ph.D. graduates are encouraged to apply. More information at http://www.deaconesculab.com Interested candidates should send a CV, one page research experience summary and contact information for three references to firstname.lastname@example.org. Salary and starting date are negotiable. Please write Postdoctoral Candidate in the e-mail subject header. Brown University, an Ivy League school, is located less than one hour away by train from Boston.
Posting Date: November 8, 2017
RESEARCH TECHNICIAN POSITION At Brown University (Structural Biology) The Deaconescu Lab at Brown University (Providence, RI) is seeking a highly motivated individual to work as a Research Assistant. The Deaconescu Laboratory focuses on structural studies by X-ray crystallography, small-angle X-ray scattering and electron microscopy of protein-protein and protein-nucleic acid complexes, particularly those involved in DNA repair and transcriptional regulation. The desired candidate will be responsible for performing routine lab work including media preparation, the preparation of solutions and stocks, cloning, large-scale protein expression, protein purification using an Akta chromatographic system, protein characterization using functional and biophysical methods (fluorescence, activity assays, circular dichroism, ITC), and protein crystallization.
Additional responsibilities include performing general lab administration, which includes the organization and maintenance of lab databases and stocks, ordering, data entry and other duties as assigned. Applicant should be highly motivated with thorough, methodological and accurate work habits. The ideal candidate has a strong ability to multi-task and good communication skills. More information at http://www.deaconesculab.com
Qualifications: Bachelor's or Master’s degree in a biological science or chemistry is required. Biological laboratory experience is required. Previous experience with molecular biology techniques (PCR, vector construction, nucleic acid extraction), protein expression, biochemistry (protein purification, enzyme assays, immunoblotting), protein crystallization are highly desirable. To apply, please send a CV, undergraduate transcript and contact information for three references to email@example.com. Write “technician candidate” in the subject line. Position is available immediately, but start date is flexible.
Posting Date: November 8, 2017
The Hospital For Sick Children Research Institute
Research Associate Position - Structure-based protein engineering - Hospital for Sick Children Research Institute, Toronto, Canada
Dr. Julien’s laboratory at The Hospital for Sick Children Research Institute (https://lab.research.sickkids.ca/julien/) is looking for a Computational Biologist to join our Structural Immunology team as a Research Associate. The successful candidate will participate in the design and engineering of antigens and antibodies in our quest to develop effective immunogens and immunotherapies. We are looking for a driven, enthusiastic and experienced scientist who demonstrates passion and creativity towards the structure/function study of important pathogenic targets and who can thrive in a highly-collaborative setting.
Roles & Responsibilities
_Use computational biology approaches to design and optimize proteins from available antibody-antigen crystal structures;
_Apply computational biology to engineer protein nanoparticles with optimal delivery properties;
_Interact across research teams to enhance computational biology applications related to vaccine design and antibody therapeutic development;
_Coordinate projects with international collaborators, including timely presentation of results and joint writing of reports.
Desired Skills and Experience
Computational/Structural Biologist with a PhD in Biochemistry, Computational Biology, Molecular Biology, Immunology, or related field. Post-doctoral experience is a plus;
_Demonstrated ability to participate in collaborative and productive scientific projects;
_Organization skills, efficiency and meticulous record keeping;
_Experience in supervising and mentoring junior members of a research team;
_Practical experience in using protein evolution or yeast/mammalian display approaches to improve antibody-antigen binding interfaces is a plus;
_Strong knowledge of using structural biology to study pathogens, especially in a context of structure-based vaccine design is a plus;
_Experience in molecular biology, protein expression in various systems, purification and biophysical characterization is a plus.
How to Apply? Send your CV and a letter of intent to firstname.lastname@example.org before Nov 20th 2017. Successful candidates will be notified for interviews, at which time two letters of references will also be required. Anticipated start date is early 2018.
About Us Dr. Julien's laboratory is interested in the structure/function study of B cell receptors and antibody interactions with antigens. A better understanding of the structures of B cell surface molecules and their secreted antibodies will serve towards the rational design of improved vaccine immunogens against a variety of pathogens, including malaria and HIV-1. Structure-based design is also applied to optimize antibody therapeutics to deplete dysregulated B cells in blood cancers and autoimmune disorders. Dr. Julien’s laboratory is located in The Peter Gilgan Centre for Research and Learning, a new 21-story, 750,000 square-foot facility that incorporates an open-concept design, state-of-the-art research facilities, and collaborative work spaces. As a member of the SickKids community, you will become part of a world-renowned organization dedicated to fulfilling a vision of Healthier Children, A Better World. For over 135 years, SickKids has worked hard to make the world a better place for children and their families. Each day, people around the organization are doing meaningful work that directly, and often indirectly, benefits children in Canada and around the world.
Posting Date: November 2, 2017
We welcome postdoctoral applicants who are interested in the structural biology of human innate immunity and viral replication, using techniques of crystallography, solution biochemistry and cryo-electron microscopy. The vibrant intellectual environment of Yale University, the diverse and collaborative nature of my lab, coupled with state-of-the-art biophysical instrumentation facilities on campus, make the Pyle laboratory an ideal environment for studying the machinery of host-pathogen interactions and RNA-protein complexes. As described on our website (http://pylelab.org), our cutting-edge projects on innate immune receptors, viral replication proteins, and RNA tertiary structures have opened up new areas of investigation that are being pursued in labs around the world. If you are interested in joining our team, please send your CV, the email addresses of two references, and a cover letter explaining your interests and fit with our lab to email@example.com.
Posting Date: August 21, 2017
UMass Medical School
A postdoctoral position is available in the Schiffer laboratory at UMass Medical School to work on structural biology of proteins related to viral infections and drug resistance. UMass Medical School is home to a newly built state-of-the-art cryo-EM facility, with a vibrant research community in structural biology. To learn about the Schiffer Lab and research program, please visit: http://www.umassmed.edu/schifferlab Applicant must have (or expect to obtain shortly) a Ph.D. in Biochemistry, Biophysics, or a related field. Previous experience and excellent skills in protein crystallography are required, including: protein expression/purification, protein crystallization, data collection, structure determination and analysis (and familiarity with the latest generation software in the field). Additional experience in the following areas is a plus: small molecule binding to proteins, molecular dynamics simulations, and enzyme kinetics. Crystal structures will include potential co-crystal structures with small molecules, nucleic acids and protein-protein complexes. The candidate is expected to complement crystallographic data with biochemical and biophysical assays, work closely with a diverse interdisciplinary research team, and be motivated to acquire new experimental and computational skills – including potentially cryo-EM. MINIMUM QUALIFICATIONS: A Ph.D. degree in Biochemistry, Biophysics, or a related field Proficient in Protein Crystallography (protein crystallization, data collection, structure determination and analysis) Experience in protein expression and purification Ability to work in a multidisciplinary team environment Please send a cover letter explaining your fit for the position and your CV to: SchifferLab@umassmed.edu
Posting Date: August 11, 2017