Our position postings page advertises open positions for postdocs, students, faculty, and staff in SBGrid member laboratories and institutions. Please send brief descriptions to Michelle. Postings will remain online for 60 days
Cryo-Electron Microscopy Research Center
University of Wisconsin, Madison, Dept of Biochemistry
Assistant Scientist, Cryo-EM Research Center: The UW-Madison Cryo-EM initiative is a cross-campus effort to provide modern cryo-electron microscopy capabilities to UW-Madison bioscience researchers. Current equipment includes a Tecnai TF-30 with a Gatan K2 Summit direct detector, a Tecnai T12 with a Gatan OneView CMOS detector, Vitrobot plunge-freezer, RMC HP 010 high-pressure freezer, a cryo-ultramicrotome, and a Leica EM ACE600 Carbon-Coating Device. A 300 kV Titan Krios, 200 kV Talos Arctica, 120 kV Talos L120C, and an Aquilos cryo-FIB-SEM will be added in the coming 12 months. New spaces are being renovated to house the microscopes, supporting equipment, computational workspace, and workspace for the new cryo-EM Scientist.
This is an annual (12-month) academic staff position.
Principal duties will include the following:
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The Cryo-EM Scientist will help identify research problems, design research methodologies/experiments to maximize use of the electron microscopes, perform and/or oversee research activities associated with the electron microscopes, and assist in preparing data results for professional presentation and/or publication. (10%)
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The Cryo-EM Scientist will develop skills through additional training on the cryo-electron microscopes and computational analysis methods to be able to use these microscopes and train investigators on the instruments. Processing and analysis of digital images is an intrinsic part of this process. The Cryo-EM facility will offer users either direct use of the instruments (with training) or indirect use for imaging conducted by the Cryo-EM Scientist. (20%)
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The Cryo-EM Scientist will facilitate use by UW-Madison bioscience researchers of the TF-30 and T12 microscopes in the UW-Madison Nanoscale Imaging and Analysis Center. (20%)
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The Cryo-EM Scientist will facilitate use by UW-Madison bioscience researchers of the 300 kV Titan Krios, 200 kV Talos Arctica, 120 kV Talos L120C, and an Aquilos cryo-FIB-SEM, once installed, including clipping of grids and their proper transfer in and out of the microscopes. (30%)
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The Cryo-EM Scientist will train new users in use of cryo-electron microscopes and periodic workshops or guest lectures in courses to acquaint bioscience researchers with cryo-EM methodologies. (5%)
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The Cryo-EM Scientist will coordinate researcher access to appropriate software for analysis of cryo-EM data. (10%)
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The Cryo-EM Scientist will communicate regularly and as needed - discussing operational updates, issues and concerns - directly with the Cryo-EM Center Director. (5%)
Apply here: https://jobs.hr.wisc.edu/cw/en-us/job/501668/assistant-scientist-cryoem-research-center
Posting Date: Aug 1, 2019
Cryo-Electron Microscopy Research Center
University of Wisconsin, Madison, Dept of Biochemistry
Computer Scientist / System Administrator: The Cryo-Electron Microscopy (Cryo-EM) Research Center in the Department of Biochemistry at the University of Wisconsin - Madison, seeks to hire an assistant, associate, or senior scientist as a computer scientist/system administrator. The Center will house a Titan Krios and a Talos Arctica (both instruments equipped with the Falcon III detector, the Gatan Bioquantum K3 energy filter-detector combination, and Volta phase plate system); a Talos 120 kV TEM; and an Aquilos cryo-Dual Beam system. A cryo-CLEM microscope for correlative microscopy pipelines will be available. Ancillary specimen preparation equipment is in place.
As a key member of the Cryo-EM Research Center, the primary responsibilities of the Computer Scientist/System Administrator are to identify Cryo-EM computational/imaging related research problems, provide computational expertise in experimental design and provide computational support for the Cryo-EM Research Center's activities. Working with the Center Director and staff, the Computer Scientist/System Administrator develops and uses existing software, pipelines, and database systems to analyze and manage Cryo-EM structural data.
Develops methodologies and provides support associated with the microscope and image detector computers and servers, the Cryo-EM Research Center cluster, and collaborates with other IT units at UW-Madison for cryo-EM structure determination and data interpretation.
The Cryo-EM Center Computer Scientist/System Administrator reports directly to the Cryo-EM Research Center Director.
Apply here: https://jobs.hr.wisc.edu/cw/en-us/job/502152/computer-scientistsystem-administrator
Posting Date: Aug 1, 2019
National Magnetic Resonance Facility
University of Wisconsin, Madison
Research Associate (Postdoctoral): A postdoctoral research associate position is immediately available at the National Magnetic Resonance Facility At Madison (NMRFAM) in the Department of Biochemistry at the University of Wisconsin-Madison. The successful candidate must have a Ph. D. in relevant computational multi-dimensional nuclear magnetic resonance (NMR) spectroscopy, or computer science and engineering fields. Expertise in developing software in a Linux environment using a variety of languages including PYTHON, C/C++, MATLAB and SQL is required. Knowledge in NMR-based structural biology and protein 3D structure is preferred. The successful candidate should be highly motivated researcher eager to communicate with the PI and have a track record of publication in quality peer-reviewed journals.
Job Duties: Under the guidance of Dr. Woonghee Lee, the Research Associate (Postdoctoral) will develop cyberinfrastructure of the computational solid-state NMR (ssNMR) for proteins that includes automated NMR spectral analysis methods, web servers and graphical user interfaces (GUIs). The researcher will participate in developing ssNMR versions analogous to popular solution NMR tools like I-PINE (http://i-pine.nmrfam.wisc.edu), PONDEROSA-C/S (http://ponderosa.nmrfam.wisc.edu) and NMRFAM-SPARKY (https://nmrfam.wisc.edu/nmrfam-sparky-distribution/). The NMRFAM provides many opportunities to interact with associated faculties including Profs. John Markley, Katherine Henzler-Wildman, Samuel Butcher and Chad Rienstra and also many collaboration opportunities with external on- and off-campus groups.
Please send CV with list of references to be sent to Woonghee Lee at whlee@nmrfam.wisc.edu
About NMRFAM: The National Magnetic Resonance Facility at Madison (NMRFAM) was established in 1987 as a NIH P41 facility under the National Center for Research Resources (NCRR), and it was transferred to NIGMS in 2012 after NCRR was phased out. NMRFAM currently occupies 20,400 ft2 in the wing of Biochemistry Department completed in 1999. It includes two server rooms, a conference room, more than ten offices for NMRFAM staff members, and cubicles for students. Major equipment at NMRFAM is located in the sub-basement of the Biochemistry Laboratories building. All nine spectrometers are equipped with cryogenic probes for solution NMR and three spectrometers have ssNMR capability with a variety of ssNMR probes. The facility has excellent temperature control (± 1 °C) and three layers of electrical backup for all critical instrumentation (battery, diesel generator, and plug for an external generator). A joint computer systems administrator for NMRFAM and BMRB manages computing servers in two server rooms with four cluster mount racks at NMRFAM. Percent Time: 100% Salary: NIH Stipend Rate
Posting Date: July 29, 2019