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109 Member Publications for April

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TMC function, dysfunction, and restoration in mouse vestibular organs.
1. Front Neurol - published April 19, 2024
2. Ratzan EM, Lee J, Madison MA, Zhu H, Zhou W, Géléoc GSG, Holt JR
The SARM1 TIR domain produces glycocyclic ADPR molecules as minor products.
1. PLoS One - published April 18, 2024
2. Garb J, Amitai G, Lu A, Ofir G, Brandis A, Mehlman T, Kranzusch PJ, Sorek R
Treatment algorithms of relapsing multiple sclerosis: an exploration based on the available disease-modifying therapies in China.
1. Ther Adv Neurol Disord - published April 15, 2024
2. Guo J, Wu J, Wang L, Liu H, Wu X, Yang H, Li W, Wang H, Bu B, Yang C, Zhou H, Guo S, Zhao Y, Wang Z, Li C, Tian DC, Chen S, Xue H, Zhang Y, Xu Y, Liang H, Wu Z, Zhang Y, Dong Q, Wang J, Quan C
Induction of islet autoimmunity to defective ribosomal product of the insulin gene as neoantigen after anti-cancer immunotherapy leading to autoimmune diabetes.
1. Front Immunol - published April 10, 2024
2. van Tienhoven R, Jansen DTSL, Park M, Williams JC, Larkin J, Quezada SA, Roep BO
Hypothiocyanous acid reductase is critical for host colonization and infection by Streptococcus pneumoniae.
1. J Biol Chem - published April 9, 2024
2. Shearer HL, Currie MJ, Agnew HN, Trappetti C, Stull F, Pace PE, Paton JC, Dobson RCJ, Dickerhof N
The graduate school guide: How to prepare for the qualifying exam and assemble a thesis/graduate committee.
1. J Cell Physiol - published April 9, 2024
2. Rogers CD, Kirabo A, McReynolds M, Sweetwyne MT, Wanjalla C, Benjamin J, Williams EM, Gaddy JA, Williams CR, Damo SM, Murray SA, Hinton A Jr
Emerging strategies for prospective discovery of molecular glue degraders.
1. Curr Opin Struct Biol - published April 9, 2024
2. Wang B, Cao S, Zheng N
Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51.
1. Nat Cell Biol - published April 9, 2024
2. Liu A, Kage F, Abdulkareem AF, Aguirre-Huamani MP, Sapp G, Aydin H, Higgs HN
Intestinal inflammation marker calprotectin regulates epithelial intestinal zinc metabolism and proliferation in mouse jejunal organoids.
1. Biomed Pharmacother - published April 8, 2024
2. González R, Ceacero-Heras D, Tena-Garitaonaindia M, Álvarez-Mercado A, Gámez-Belmonte R, Chazin WJ, Sánchez de Medina F, Martínez-Augustin O
Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding.
1. Nat Neurosci - published April 8, 2024
2. Hacisuleyman E, Hale CR, Noble N, Luo JD, Fak JJ, Saito M, Chen J, Weissman JS, Darnell RB
The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers.
1. Cancer Discov - published April 8, 2024
2. Ryan MB, Quade B, Schenk N, Fang Z, Zingg M, Cohen SE, Swalm BM, Li C, Ozen A, Ye C, Ritorto MS, Huang X, Dar AC, Han Y, Hoeflich KP, Hale M, Hagel M
The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili.
1. Nat Commun - published April 8, 2024
2. Zyla DS, Wiegand T, Bachmann P, Zdanowicz R, Giese C, Meier BH, Waksman G, Hospenthal MK, Glockshuber R
Phase 1 trial evaluating safety and pharmacokinetics of HIV-1 broadly neutralizing mAbs 10E8VLS and VRC07-523LS.
1. JCI Insight - published April 8, 2024
2. Awan SF, Pegu A, Strom L, Carter CA, Hendel CS, Holman LA, Costner PJ, Trofymenko O, Dyer R, Gordon IJ, Rothwell RSS, Hickman SP, Conan-Cibotti M, Doria-Rose NA, Lin BC, O'Connell S, Narpala SR, Almasri CG, Liu C, Ko S, Kwon YD, Namboodiri AM, Pandey JP, Arnold FJ, Carlton K, Gall JG, Kwong PD, Capparelli EV, Bailer RT, McDermott AB, Chen GL, Koup RA, Mascola JR, Coates EE, Ledgerwood JE, Gaudinski MR, VRC 610 study team
Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics.
1. bioRxiv - published April 7, 2024
2. Carlson RJ, Patten JJ, Stefanakis G, Soong BY, Radhakrishnan A, Singh A, Thakur N, Amarasinghe GK, Hacohen N, Basler CF, Leung D, Uhler C, Davey RA, Blainey PC
The structure of the monobactam-producing thioesterase domain of SulM forms a unique complex with the upstream carrier protein domain.
1. bioRxiv - published April 6, 2024
2. Patel KD, Oliver RA, Lichstrahl MS, Li R, Townsend CA, Gulick AM
Uncovering Protein Ensembles: Automated Multiconformer Model Building for X-ray Crystallography and Cryo-EM.
1. bioRxiv - published April 6, 2024
2. Wankowicz SA, Ravikumar A, Sharma S, Riley BT, Raju A, Flowers J, Hogan D, van den Bedem H, Keedy DA, Fraser JS
Biochemical characterization of E. coli DnaC variants that alter DnaB helicase loading onto DNA.
1. J Biol Chem - published April 6, 2024
2. McMillan SD, Keck JL
NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation.
1. Cell Rep - published April 6, 2024
2. Yu T, Hou D, Zhao J, Lu X, Greentree WK, Zhao Q, Yang M, Conde DG, Linder ME, Lin H
The 3' UTR of vigR is required for virulence in Staphylococcus aureus and has expanded through STAR sequence repeat insertions.
1. Cell Rep - published April 6, 2024
2. Mediati DG, Dan W, Lalaouna D, Dinh H, Pokhrel A, Rowell KN, Michie KA, Stinear TP, Cain AK, Tree JJ
RNA genome packaging and capsid assembly of bluetongue virus visualized in host cells.
1. Cell - published April 5, 2024
2. Xia X, Sung PY, Martynowycz MW, Gonen T, Roy P, Zhou ZH
A highly optimized human in vitro translation system.
1. Cell Rep Methods - published April 5, 2024
2. Bothe A, Ban N
Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling.
1. Mol Cell - published April 5, 2024
2. Caveney NA, Rodriguez GE, Pollmann C, Meyer T, Borowska MT, Wilson SC, Wang N, Xiang X, Householder KD, Tao P, Su LL, Saxton RA, Piehler J, Garcia KC
Membrane Lipids Augment Cell Envelope Stress Signaling via the MadRS System to Defend Against Antimicrobial Peptides and Antibiotics in Enterococcus faecalis.
1. J Infect Dis - published April 5, 2024
2. Miller WR, Nguyen A, Singh KV, Rizvi S, Khan A, Erickson SG, Egge SL, Cruz M, Dinh AQ, Diaz L, Thornton PC, Zhang R, Xu L, Garsin DA, Shamoo Y, Arias CA
Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes.
1. Sci Adv - published April 5, 2024
2. Sauer PV, Cupellini L, Sutter M, Bondanza M, Domínguez Martin MA, Kirst H, Bína D, Koh AF, Kotecha A, Greber BJ, Nogales E, Polívka T, Mennucci B, Kerfeld CA
Nutritional, physicochemical, and functional properties of Hawaiian taro (Colocasia esculenta) flours: A comparative study.
1. J Food Sci - published April 5, 2024
2. Saxby SM, Dong L, Ho KKHY, Lee CN, Wall M, Li Y
De novo design of drug-binding proteins with predictable binding energy and specificity.
1. Science - published April 5, 2024
2. Lu L, Gou X, Tan SK, Mann SI, Yang H, Zhong X, Gazgalis D, Valdiviezo J, Jo H, Wu Y, Diolaiti ME, Ashworth A, Polizzi NF, DeGrado WF
Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors.
1. Cell Chem Biol - published April 4, 2024
2. Dates AN, Jones DTD, Smith JS, Skiba MA, Rich MF, Burruss MM, Kruse AC, Blacklow SC
Structural characterization of methylation-independent PP2A assembly guides Alphafold2Multimer prediction of family-wide PP2A complexes.
1. J Biol Chem - published April 4, 2024
2. Wachter F, Nowak RP, Ficarro S, Marto J, Fischer ES
Intrinsic disorder: A term to define the specific physicochemical characteristic of protein conformational heterogeneity.
1. Mol Cell - published April 4, 2024
2. Lemke EA, Babu MM, Kriwacki RW, Mittag T, Pappu RV, Wright PE, Forman-Kay JD
The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2.
1. PLoS Pathog - published April 4, 2024
2. de Sautu M, Herrmann T, Scanavachi G, Jenni S, Harrison SC
Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization.
1. Front Mol Neurosci - published April 4, 2024
2. Chofflet N, Naito Y, Pastore AJ, Padmanabhan N, Nguyen PT, Poitras C, Feller B, Yi N, Van Prooijen J, Khaled H, Coulombe B, Clapcote SJ, Bourgault S, Siddiqui TJ, Rudenko G, Takahashi H
Anaerobic cryoEM protocols for air-sensitive nitrogenase proteins.
1. Nat Protoc - published April 4, 2024
2. Warmack RA, Wenke BB, Spatzal T, Rees DC
Variable orthogonality of RDF - large serine integrase interactions within the ϕC31 family.
1. bioRxiv - published April 3, 2024
2. MacDonald AI, Baksh A, Holland A, Shin H, Rice PA, Stark WM, Olorunniji FJ
Sirt2 inhibition improves gut epithelial barrier integrity and protects mice from colitis.
1. Proc Natl Acad Sci U S A - published April 3, 2024
2. Hou D, Yu T, Lu X, Hong JY, Yang M, Zi Y, Ho TT, Lin H
Cell penetration of oxadiazole-containing macrocycles.
1. RSC Chem Biol - published April 3, 2024
2. Huh S, Batistatou N, Wang J, Saunders GJ, Kritzer JA, Yudin AK
Buffer Choice and pH Strongly Influence Phase Separation of SARS-CoV-2 Nucleocapsid with RNA.
1. Mol Biol Cell - published April 3, 2024
2. Kathe NC, Novakovic M, Allain FH
Therapeutic administration of a cross-reactive mAb targeting the fusion glycoprotein of Nipah virus protects nonhuman primates.
1. Sci Transl Med - published April 3, 2024
2. Zeitlin L, Cross RW, Woolsey C, West BR, Borisevich V, Agans KN, Prasad AN, Deer DJ, Stuart L, McCavitt-Malvido M, Kim DH, Pettitt J, Crowe JE Jr, Whaley KJ, Veesler D, Dimitrov A, Abelson DM, Geisbert TW, Broder CC
Combining Rosetta Sequence Design with Protein Language Model Predictions Using Evolutionary Scale Modeling (ESM) as Restraint.
1. ACS Synth Biol - published April 3, 2024
2. Ertelt M, Meiler J, Schoeder CT
Activating point mutations in the MET kinase domain represent a unique molecular subset of lung cancer and other malignancies targetable with MET inhibitors.
1. Cancer Discov - published April 3, 2024
2. Pecci F, Nakazawa S, Ricciuti B, Harada G, Lee JK, Alessi JV, Barrichello A, Vaz VR, Lamberti G, Di Federico A, Gandhi MM, Gazgalis D, Feng WW, Jiang J, Baldacci S, Locquet MA, Gottlieb FH, Chen MF, Lee E, Haradon D, Smokovich A, Voligny E, Nguyen T, Goel VK, Zimmerman Z, Atwal S, Wang X, Bahcall M, Heist RS, Iqbal S, Gandhi N, Elliott A, Vanderwalde AM, Ma PC, Halmos B, Liu SV, Che J, Schrock AB, Drilon A, Janne PA, Awad MM
Cryo-EM Structure of AAV2 Rep68 bound to integration site AAVS1: Insights into the mechanism of DNA melting.
1. bioRxiv - published April 2, 2024
2. Jaiswal R, Santosh V, Braud B, Washington A, Escalante CR
Covalent Polymer-RNA Conjugates for Potent Activation of the RIG-I Pathway.
1. Adv Healthc Mater - published April 2, 2024
2. Palmer CR, Pastora LE, Kimmel BR, Pagendarm HM, Kwiatkowski AJ, Stone PT, Arora K, Francini N, Fedorova O, Pyle AM, Wilson JT
Compositional Analysis of Complex Mixtures using Automatic MicroED Data Collection.
1. Adv Sci (Weinh) - published April 2, 2024
2. Unge J, Lin J, Weaver SJ, Sae Her A, Gonen T
GS-441524-Diphosphate-Ribose Derivatives as Nanomolar Binders and Fluorescence Polarization Tracers for SARS-CoV-2 and Other Viral Macrodomains.
1. ACS Chem Biol - published April 2, 2024
2. Peng K, Wallace SD, Bagde SR, Shang J, Anmangandla A, Jana S, Fromme JC, Lin H
NLRP inflammasomes in health and disease.
1. Mol Biomed - published April 2, 2024
2. Xu Z, Kombe Kombe AJ, Deng S, Zhang H, Wu S, Ruan J, Zhou Y, Jin T
A comprehensive dataset of protein-protein interactions and ligand binding pockets for advancing drug discovery.
1. Sci Data - published April 2, 2024
2. Moine-Franel A, Mareuil F, Nilges M, Ciambur CB, Sperandio O
Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex.
1. Proc Natl Acad Sci U S A - published April 2, 2024
2. Nguyen DM, Rath DH, Devost D, Pétrin D, Rizk R, Ji AX, Narayanan N, Yong D, Zhai A, Kuntz DA, Mian MUQ, Pomroy NC, Keszei AFA, Benlekbir S, Mazhab-Jafari MT, Rubinstein JL, Hébert TE, Privé GG
Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix.
1. Proc Natl Acad Sci U S A - published April 2, 2024
2. Bellone S, Jeong K, Halle MK, Krakstad C, McNamara B, Greenman M, Mutlu L, Demirkiran C, Hartwich TMP, Yang-Hartwich Y, Zipponi M, Buza N, Hui P, Raspagliesi F, Lopez S, Paolini B, Milione M, Perrone E, Scambia G, Altwerger G, Ravaggi A, Bignotti E, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz PE, Quick CM, Angioli R, Terranova C, Zaidi S, Nandi S, Alexandrov LB, Siegel ER, Choi J, Schlessinger J, Santin AD
Proof-of-concept studies with a computationally designed M(pro) inhibitor as a synergistic combination regimen alternative to Paxlovid.
1. Proc Natl Acad Sci U S A - published April 2, 2024
2. Papini C, Ullah I, Ranjan AP, Zhang S, Wu Q, Spasov KA, Zhang C, Mothes W, Crawford JM, Lindenbach BD, Uchil PD, Kumar P, Jorgensen WL, Anderson KS
Lipid scrambling is a general feature of protein insertases.
1. Proc Natl Acad Sci U S A - published April 2, 2024
2. Li D, Rocha-Roa C, Schilling MA, Reinisch KM, Vanni S
NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks.
1. Cell - published April 2, 2024
2. David L, Borges JP, Hollingsworth LR, Volchuk A, Jansen I, Garlick E, Steinberg BE, Wu H
Viral Receptor-Binding Protein Evolves New Function through Mutations That Cause Trimer Instability and Functional Heterogeneity.
1. Mol Biol Evol - published April 2, 2024
2. Strobel HM, Labador SD, Basu D, Sane M, Corbett KD, Meyer JR
Structural basis of ligand specificity and channel activation in an insect gustatory receptor.
1. Cell Rep - published April 2, 2024
2. Frank HM, Walujkar S, Walsh RM Jr, Laursen WJ, Theobald DL, Garrity PA, Gaudet R
Backbone chemical shift and secondary structure assignments for mouse siderocalin.
1. Biomol NMR Assign - published April 2, 2024
2. Moeller J, Bozhanova NG, Voehler M, Meiler J, Schoeder CT
Author Correction: Automating data analysis for hydrogen/deuterium exchange mass spectrometry using data-independent acquisition methodology.
1. Nat Commun - published April 2, 2024
2. Filandr F, Sarpe V, Raval S, Crowder DA, Khan MF, Douglas P, Coales S, Viner R, Syed A, Tainer JA, Lees-Miller SP, Schriemer DC
Structural basis for promiscuity in ligand recognition by yjdF riboswitch.
1. Cell Discov - published April 2, 2024
2. Krochmal D, Roman C, Lewicka A, Shao Y, Piccirilli JA
Correction: Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications.
1. Breast Cancer Res - published April 2, 2024
2. Bashari MH, Fan F, Vallet S, Sattler M, Arn M, Luckner-Minden C, Schulze-Bergkamen H, Zörnig I, Marme F, Schneeweiss A, Cardone MH, Opferman JT, Jäger D, Podar K
Author Correction: SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
1. Nature - published April 2, 2024
2. Barnes CO, Jette CA, Abernathy ME, Dam KA, Esswein SR, Gristick HB, Malyutin AG, Sharaf NG, Huey-Tubman KE, Lee YE, Robbiani DF, Nussenzweig MC, West AP Jr, Bjorkman PJ
Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway.
1. Nat Microbiol - published April 2, 2024
2. Yan Y, Xiao J, Huang F, Xian W, Yu B, Cheng R, Wu H, Lu X, Wang X, Huang W, Li J, Oyejobi GK, Robinson CV, Wu H, Wu D, Liu X, Wang L, Zhu B
Human Airway and Alveolar Organoids from Bronchoalveolar Lavage Fluid.
1. Am J Respir Crit Care Med - published April 2, 2024
2. Liu MY, Chen B, Borji M, Garcia de Alba Rivas C, Dost AFM, Moye AL, Movval Abdulla N, Paschini M, Rollins SD, Wang R, Schnapp LM, Khalil HA, Wu CJ, Sharma NS, Kim CF
Nanoparticle Retinoic Acid-Inducible Gene I Agonist for Cancer Immunotherapy.
1. ACS Nano - published April 2, 2024
2. Wang-Bishop L, Wehbe M, Pastora LE, Yang J, Kimmel BR, Garland KM, Becker KW, Carson CS, Roth EW, Gibson-Corley KN, Ulkoski D, Krishnamurthy V, Fedorova O, Richmond A, Pyle AM, Wilson JT
Structural basis for α-tubulin-specific and modification state-dependent glutamylation.
1. Nat Chem Biol - published April 2, 2024
2. Mahalingan KK, Grotjahn DA, Li Y, Lander GC, Zehr EA, Roll-Mecak A
PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association.
1. Elife - published April 2, 2024
2. Proske M, Janowski R, Bacher S, Kang HS, Monecke T, Koehler T, Hutten S, Tretter J, Crois A, Molitor L, Varela-Rial A, Fino R, Donati E, De Fabritiis G, Dormann D, Sattler M, Niessing D
Discovering mechanisms of human genetic variation and controlling cell states at scale.
1. Trends Genet - published April 2, 2024
2. Frenkel M, Raman S
Broadening the Utility of Farnesyltransferase-Catalyzed Protein Labeling Using Norbornene-Tetrazine Click Chemistry.
1. Bioconjug Chem - published April 2, 2024
2. Auger SA, Venkatachalapathy S, Suazo KFG, Wang Y, Sarkis AW, Bernhagen K, Justyna K, Schaefer JV, Wollack JW, Plückthun A, Li L, Distefano MD
NEIL3: A unique DNA glycosylase involved in interstrand DNA crosslink repair.
1. DNA Repair (Amst) - published April 2, 2024
2. Oswalt LE, Eichman BF
Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST.
1. bioRxiv - published April 1, 2024
2. Sprenger HG, Mittenbühler MJ, Sun Y, Van Vranken JG, Schindler S, Jayaraj A, Khetarpal SA, Vargas-Castillo A, Puszynska AM, Spinelli JB, Armani A, Kunchok T, Ryback B, Seo HS, Song K, Sebastian L, O'Young C, Braithwaite C, Dhe-Paganon S, Burger N, Mills EL, Gygi SP, Arthanari H, Chouchani ET, Sabatini DM, Spiegelman BM
Small-Molecule Inhibitors of the m7G-RNA Writer METTL1.
1. ACS Bio Med Chem Au - published April 1, 2024
2. Nai F, Flores Espinoza MP, Invernizzi A, Vargas-Rosales PA, Bobileva O, Herok M, Caflisch A
Automated liver volumetry and hepatic steatosis quantification with magnetic resonance imaging proton density fat fraction.
1. J Formos Med Assoc - published April 1, 2024
2. Chang YC, Yen KC, Liang PC, Ho MC, Ho CM, Hsiao CY, Hsiao CH, Lu CH, Wu CH
The making and breaking of tRNAs by ribonucleases.
1. Trends Genet - published April 1, 2024
2. Elder JJH, Papadopoulos R, Hayne CK, Stanley RE
Sulfate-reducing bacteria (SRB) mediated carbonate dissolution and arsenic release: Behavior and mechanisms.
1. Sci Total Environ - published April 1, 2024
2. Jiang Y, Gao X, Yang X, Gong P, Pan Z, Yi L, Ma S, Li C, Kong S, Wang Y
Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II.
1. Eur J Cell Biol - published April 1, 2024
2. Gebregiworgis T, Chan JY, Kuntz DA, Privé GG, Marshall CB, Ikura M
Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells.
1. Nat Biomed Eng - published April 1, 2024
2. Lee D, Huntoon K, Wang Y, Kang M, Lu Y, Jeong SD, Link TM, Gallup TD, Qie Y, Li X, Dong S, Schrank BR, Grippin AJ, Antony A, Ha J, Chang M, An Y, Wang L, Jiang D, Li J, Koong AC, Tainer JA, Jiang W, Kim BYS
Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis.
1. J Biol Chem - published April 1, 2024
2. Calver JF, Parmar NR, Harris G, Lithgo RM, Stylianou P, Zetterberg FR, Gooptu B, Mackinnon AC, Carr SB, Borthwick LA, Scott DJ, Stewart ID, Slack RJ, Jenkins RG, John AE
Ensuring a sustained workforce to combat antibiotic resistance in the 21st century: the critical need for training the next-gen of scientists at the pre-doctoral level.
1. Antimicrob Agents Chemother - published April 1, 2024
2. Shafer WM, Conn GL
The M3 muscarinic acetylcholine receptor can signal through multiple G protein families.
1. Mol Pharmacol - published April 1, 2024
2. Smith JS, Hilibrand AS, Skiba MA, Dates AN, Calvillo-Miranda VG, Kruse AC
Structural Basis of Non-Latent Signaling by the Anti-Müllerian Hormone Procomplex.
1. bioRxiv - published April 1, 2024
2. Howard JA, Hok L, Cate RL, Sanford NJ, Hart KN, Leach EA, Bruening AS, Pépin D, Donahoe PK, Thompson TB
A secreted bacterial protein protects bacteria from cationic antimicrobial peptides by entrapment in phase-separated droplets.
1. PNAS Nexus - published April 1, 2024
2. Ostan NKH, Cole GB, Wang FZ, Reichheld SE, Moore G, Pan C, Yu R, Lai CC, Sharpe S, Lee HO, Schryvers AB, Moraes TF
Discovery of Protease-Activated Receptor 4 (PAR4)-Tethered Ligand Antagonists Using Ultralarge Virtual Screening.
1. ACS Pharmacol Transl Sci - published April 1, 2024
2. Smith ST, Cassada JB, Von Bredow L, Erreger K, Webb EM, Trombley TA, Kalbfleisch JJ, Bender BJ, Zagol-Ikapitte I, Kramlinger VM, Bouchard JL, Mitchell SG, Tretbar M, Shoichet BK, Lindsley CW, Meiler J, Hamm HE
Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages.
1. Immunity - published April 1, 2024
2. Mandula JK, Sierra-Mondragon RA, Jimenez RV, Chang D, Mohamed E, Chang S, Vazquez-Martinez JA, Cao Y, Anadon CM, Lee SB, Das S, Rocha-Munguba L, Pham VM, Li R, Tarhini AA, Furqan M, Dalton W, Churchman M, Moran-Segura CM, Nguyen J, Perez B, Kojetin DJ, Obermayer A, Yu X, Chen A, Shaw TI, Conejo-Garcia JR, Rodriguez PC
RNA targeting and cleavage by the type III-Dv CRISPR effector complex.
1. Nat Commun - published April 1, 2024
2. Schwartz EA, Bravo JPK, Ahsan M, Macias LA, McCafferty CL, Dangerfield TL, Walker JN, Brodbelt JS, Palermo G, Fineran PC, Fagerlund RD, Taylor DW
Promiscuous G-protein activation by the calcium-sensing receptor.
1. Nature - published April 1, 2024
2. Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR
CryoEM structures reveal how the bacterial flagellum rotates and switches direction.
1. Nat Microbiol - published April 1, 2024
2. Singh PK, Sharma P, Afanzar O, Goldfarb MH, Maklashina E, Eisenbach M, Cecchini G, Iverson TM
DNA glycosylases provide antiviral defence in prokaryotes.
1. Nature - published April 1, 2024
2. Hossain AA, Pigli YZ, Baca CF, Heissel S, Thomas A, Libis VK, Burian J, Chappie JS, Brady SF, Rice PA, Marraffini LA
Modulation of peroxisomal import by the PEX13 SH3 domain and a proximal FxxxF binding motif.
1. Nat Commun - published April 1, 2024
2. Gaussmann S, Peschel R, Ott J, Zak KM, Sastre J, Delhommel F, Popowicz GM, Boekhoven J, Schliebs W, Erdmann R, Sattler M
HS-AFM single-molecule structural biology uncovers basis of transporter wanderlust kinetics.
1. Nat Struct Mol Biol - published April 1, 2024
2. Jiang Y, Miyagi A, Wang X, Qiu B, Boudker O, Scheuring S
Molecular basis of Gabija anti-phage supramolecular assemblies.
1. Nat Struct Mol Biol - published April 1, 2024
2. Yang XY, Shen Z, Xie J, Greenwald J, Marathe I, Lin Q, Xie WJ, Wysocki VH, Fu TM
Skin emitted volatiles analysis for noninvasive diagnosis: the current advances in sample preparation techniques for biomedical application.
1. RSC Adv - published April 1, 2024
2. S K, Saquib M, Poojary H, Illanad G, Valavan D, M S, Nayak R, Mazumder N, Ghosh C
Von Hippel Lindau tumor suppressor controls m6A-dependent gene expression in renal tumorigenesis.
1. J Clin Invest - published April 1, 2024
2. Zhang C, Yu M, Hepperla AJ, Zhang Z, Raj R, Zhong H, Zhou J, Hu L, Fang J, Liu H, Liang Q, Jia L, Liao C, Xi S, Simon JM, Xu K, Liu Z, Nam Y, Kapur P, Zhang Q
Plant-derived flavonoids are a potential source of drugs for the treatment of liver fibrosis.
1. Phytother Res - published April 1, 2024
2. Zhao B, Liu K, Liu X, Li Q, Li Z, Xi J, Xie F, Li X
Medicinal and edible polysaccharides from ancient plants: extraction, isolation, purification, structure, biological activity and market trends of sea buckthorn polysaccharides.
1. Food Funct - published April 1, 2024
2. Xu X, Liu X, Yu S, Wang T, Li R, Zhang Y, Liu Y
Structural basis for human Ca(v)3.2 inhibition by selective antagonists.
1. Cell Res - published April 1, 2024
2. Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments.
1. Nat Cell Biol - published April 1, 2024
2. Chidley C, Darnell AM, Gaudio BL, Lien EC, Barbeau AM, Vander Heiden MG, Sorger PK
An adaptive biomolecular condensation response is conserved across environmentally divergent species.
1. Nat Commun - published April 1, 2024
2. Keyport Kik S, Christopher D, Glauninger H, Hickernell CW, Bard JAM, Lin KM, Squires AH, Ford M, Sosnick TR, Drummond DA
Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer.
1. Nat Commun - published April 1, 2024
2. Fu J, Ling J, Li CF, Tsai CL, Yin W, Hou J, Chen P, Cao Y, Kang Y, Sun Y, Xia X, Jiang Z, Furukawa K, Lu Y, Wu M, Huang Q, Yao J, Hawke DH, Pan BF, Zhao J, Huang J, Wang H, Bahassi EIM, Stambrook PJ, Huang P, Fleming JB, Maitra A, Tainer JA, Hung MC, Lin C, Chiao PJ
A targetable receptor-binding site on PfCyRPA to aid in the fight against malaria.
1. Trends Parasitol - published April 1, 2024
2. Dickey TH, Tolia NH
DNA binding analysis of rare variants in homeodomains reveals homeodomain specificity-determining residues.
1. Nat Commun - published April 1, 2024
2. Kock KH, Kimes PK, Gisselbrecht SS, Inukai S, Phanor SK, Anderson JT, Ramakrishnan G, Lipper CH, Song D, Kurland JV, Rogers JM, Jeong R, Blacklow SC, Irizarry RA, Bulyk ML
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.
1. Nature - published April 1, 2024
2. Du G, Healy LB, David L, Walker C, El-Baba TJ, Lutomski CA, Goh B, Gu B, Pi X, Devant P, Fontana P, Dong Y, Ma X, Miao R, Balasubramanian A, Puthenveetil R, Banerjee A, Luo HR, Kagan JC, Oh SF, Robinson CV, Lieberman J, Wu H
Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.
1. Nat Struct Mol Biol - published April 1, 2024
2. Adolf F, Du J, Goodall EA, Walsh RM Jr, Rawson S, von Gronau S, Harper JW, Hanna J, Schulman BA
From solution to structure: empowering inclusive cryo-EM with a pre-characterization pipeline for biological samples.
1. J Appl Crystallogr - published April 1, 2024
2. Mueller-Dieckmann C, Grinzato A, Effantin G, Fenel D, Flot D, Schoehn G, Leonard G, Kandiah E
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin.
1. Elife - published April 1, 2024
2. Cacho-Navas C, López-Pujante C, Reglero-Real N, Colás-Algora N, Cuervo A, Conesa JJ, Barroso S, de Rivas G, Ciordia S, Paradela A, D'Agostino G, Manzo C, Feito J, Andrés G, Molina-Jiménez F, Majano P, Correas I, Carazo JM, Nourshargh S, Huch M, Millán J
Bridging structural and cell biology with cryo-electron microscopy.
1. Nature - published April 1, 2024
2. Nogales E, Mahamid J
Development of a [89Zr]Zr-labeled Human Antibody using a Novel Phage-displayed Human scFv Library.
1. Clin Cancer Res - published April 1, 2024
2. Singh AK, Lewis CD, Boas CAWV, Diebolder P, Jethva PN, Rhee A, Song JH, Goo YA, Li S, Nickels ML, Liu Y, Rogers BE, Kapoor V, Hallahan DE
Efficient and economic protein labeling for NMR in mammalian expression systems: Application to a preT-cell and T-cell receptor protein.
1. Protein Sci - published April 1, 2024
2. Mallis RJ, Lee JJ, Berg AVD, Brazin KN, Viennet T, Zmuda J, Cross M, Radeva D, Rodriguez-Mias R, Villén J, Gelev V, Reinherz EL, Arthanari H
Integrating the analysis of human biopsies using post-translational modifications proteomics.
1. Protein Sci - published April 1, 2024
2. Bhardwaj S, Bulluss M, D'Aubeterre A, Derakhshani A, Penner R, Mahajan M, Mahajan VB, Dufour A
Structural determination and modeling of ciliary microtubules.
1. Acta Crystallogr D Struct Biol - published April 1, 2024
2. Walton T, Doran MH, Brown A
STING guides the STX17-SNAP29-VAMP8 complex assembly to control autophagy.
1. Cell Insight - published April 1, 2024
2. Song X, Xi Y, Dai M, Li T, Du S, Zhu Y, Li M, Li Y, Liu S, Ding X, Yao X, Lai Y, Liu X
Assembly of the Bacterial Ribosome with Circularly Permuted rRNA.
1. bioRxiv - published April 1, 2024
2. Dong X, Sheng K, Gebert LFR, Aiyer S, MacRae IJ, Lyumkis D, Williamson JR
Glia-derived secretory fatty acid binding protein Obp44a regulates lipid storage and efflux in the developing Drosophila brain.
1. bioRxiv - published April 1, 2024
2. Yin J, Chen HL, Grigsby-Brown A, He Y, Cotten ML, Short J, Dermady A, Lei J, Gibbs M, Cheng ES, Zhang D, Long C, Xu L, Zhong T, Abzalimov R, Haider M, Sun R, He Y, Zhou Q, Tjandra N, Yuan Q
Multiple pathways for licensing human replication origins.
1. bioRxiv - published April 1, 2024
2. Yang R, Hunker O, Wise M, Bleichert F