Member Publications
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143 Member Publications for October 2023
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Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein.
- Cell Rep - published October 27, 2023
- Thai E, Murugan R, Binter Š, Burn Aschner C, Prieto K, Kassardjian A, Obraztsova AS, Kang RW, Flores-Garcia Y, Mathis-Torres S, Li K, Horn GQ, Huntwork RHC, Bolscher JM, de Bruijni MHC, Sauerwein R, Dennison SM, Tomaras GD, Zavala F, Kellam P, Wardemann H, Julien JP
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Germline landscape of RPA1, RPA2 and RPA3 variants in pediatric malignancies: identification of RPA1 as a novel cancer predisposition candidate gene.
- Front Oncol - published October 23, 2023
- Sharma R, Oak N, Chen W, Gogal R, Kirschner M, Beier F, Schnieders MJ, Spies M, Nichols KE, Wlodarski M
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Sec8 specifically interacts with the PDZ2 domain of synapse associated protein 102 (SAP102).
- Front Cell Dev Biol - published October 18, 2023
- Korbula K, Hammerschmid I, Lesigang J, Dong G
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A FRET-Based Assay and Computational Tools to Quantify Enzymatic Rates and Explore the Mechanisms of RNA Deadenylases in Heterogeneous Environments.
- Methods Mol Biol - published October 12, 2023
- Irwin R, Harkness RW, Forman-Kay JD
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Effects of customer relationship management (CRM) strategies and socio-cognitive constructs on the physical activity of individuals with arthritis over time.
- PLoS One - published October 10, 2023
- Newton FJ, Haregu TN, Newton JD, Donovan R, Mahal A, Mackenzie-Stewart R, Ewing MT, Bauman A, Manera KE, Smith BJ
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Histones with an unconventional DNA-binding mode in vitro are major chromatin constituents in the bacterium Bdellovibrio bacteriovorus.
- Nat Microbiol - published October 9, 2023
- Hocher A, Laursen SP, Radford P, Tyson J, Lambert C, Stevens KM, Montoya A, Shliaha PV, Picardeau M, Sockett RE, Luger K, Warnecke T
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Herpetic anterior uveitis following COVID-19 vaccines: a case series.
- Front Med (Lausanne) - published October 9, 2023
- Ott M, Nagamany T, Zandi S, Pichi F, Agarwal A, Carreño E, Gupta V, Grewal DS, Cunningham ET, Munk MR
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Antiviral responses are shaped by heterogeneity in viral replication dynamics.
- Nat Microbiol - published October 9, 2023
- Bruurs LJM, Müller M, Schipper JG, Rabouw HH, Boersma S, van Kuppeveld FJM, Tanenbaum ME
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Scaffold, mechanics and functions of nuclear lamins.
- FEBS Lett - published October 9, 2023
- Buxboim A, Kronenberg-Tenga R, Salajkova S, Avidan N, Shahak H, Thurston A, Medalia O
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Benchmarking AlphaMissense Pathogenicity Predictions Against Cystic Fibrosis Variants.
- bioRxiv - published October 9, 2023
- McDonald EF, Oliver KE, Schlebach JP, Meiler J, Plate L
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Side-Chain Dynamics of the α(1B) -Adrenergic Receptor determined by NMR via Methyl Relaxation.
- Protein Sci - published October 8, 2023
- Baumann C, Chiang WC, Valsecchi R, Jurt S, Deluigi M, Schuster M, Rosengren KJ, Plückthun A, Zerbe O
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Open structure and gating of the Arabidopsis mechanosensitive ion channel MSL10.
- Nat Commun - published October 7, 2023
- Zhang J, Maksaev G, Yuan P
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Prostate cancer progression relies on the mitotic kinase citron kinase.
- Cancer Res - published October 6, 2023
- Rawat C, Ben-Salem S, Singh N, Chauhan G, Rabljenovic A, Vaghela V, Venkadakrishnan VB, Macdonald JD, Dahiya UR, Ghanem Y, Bachour S, Su Y, DePriest AD, Lee S, Muldong M, Kim HT, Kumari S, Valenzuela MM, Zhang D, Hu Q, Cortes Gomez E, Dehm SM, Zoubeidi A, Jamieson CAM, Nicolas M, McKenney J, Willard B, Klein EA, Magi-Galluzzi C, Stauffer SR, Liu S, Heemers HV
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Exploring the Binding Pathway of Novel Nonpeptidomimetic Plasmepsin V Inhibitors.
- J Chem Inf Model - published October 6, 2023
- Bobrovs R, Drunka L, Kanepe I, Jirgensons A, Caflisch A, Salvalaglio M, Jaudzems K
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Bacterial RNA-free RNase P: structural and functional characterization of multiple oligomeric forms of a minimal protein-only ribonuclease P.
- J Biol Chem - published October 6, 2023
- Wilhelm CA, Mallik L, Kelly AL, Brotzman S, Mendoza J, Anders AG, Leskaj S, Castillo C, Ruotolo BT, Cianfrocco MA, Koutmos M
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Liquid-biopsy proteomics combined with AI identifies cellular drivers of eye aging and disease in vivo.
- Cell - published October 6, 2023
- Wolf J, Rasmussen DK, Sun YJ, Vu JT, Wang E, Espinosa C, Bigini F, Chang RT, Montague AA, Tang PH, Mruthyunjaya P, Aghaeepour N, Dufour A, Bassuk AG, Mahajan VB
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Control of the antitumour activity and specificity of CAR T cells via organic adapters covalently tethering the CAR to tumour cells.
- Nat Biomed Eng - published October 5, 2023
- Stepanov AV, Xie J, Zhu Q, Shen Z, Su W, Kuai L, Soll R, Rader C, Shaver G, Douthit L, Zhang D, Kalinin R, Fu X, Zhao Y, Qin T, Baran PS, Gabibov AG, Bushnell D, Neri D, Kornberg RD, Lerner RA
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Pass the 12-LOX!
- Blood - published October 5, 2023
- Di Cera E
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Superiority of the Triple-Acting 5-HT(6)R/5-HT(3)R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT(6)R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats.
- J Med Chem - published October 5, 2023
- Grychowska K, López-Sánchez U, Vitalis M, Canet G, Satała G, Olejarz-Maciej A, Gołębiowska J, Kurczab R, Pietruś W, Kubacka M, Moreau C, Walczak M, Blicharz-Futera K, Bantreil X, Subra G, Bojarski AJ, Lamaty F, Becamel C, Zussy C, Chaumont-Dubel S, Popik P, Nury H, Marin P, Givalois L, Zajdel P
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Universal features of Nsp1-mediated translational shutdown by coronaviruses.
- Mol Cell - published October 5, 2023
- Schubert K, Karousis ED, Ban I, Lapointe CP, Leibundgut M, Bäumlin E, Kummerant E, Scaiola A, Schönhut T, Ziegelmüller J, Puglisi JD, Mühlemann O, Ban N
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Host receptor binding induces conformational changes in a PfEMP1 protein.
- Structure - published October 5, 2023
- Ma R, Tolia NH
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Heterozygous deletion of the autism-associated gene CHD8 impairs synaptic function through widespread changes in gene expression and chromatin compaction.
- Am J Hum Genet - published October 5, 2023
- Shi X, Lu C, Corman A, Nikish A, Zhou Y, Platt RJ, Iossifov I, Zhang F, Pan JQ, Sanjana NE
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Assembly-dependent structure formation shapes human interleukin-23 versus interleukin-12 secretion.
- J Mol Biol - published October 5, 2023
- Aschenbrenner I, Siebenmorgen T, Lopez A, Parr M, Ruckgaber P, Kerle A, Rührnößl F, Catici D, Haslbeck M, Frishman D, Sattler M, Zacharias M, Feige MJ
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Beyond the Surface: Investigation of Tumorsphere morphology using volume electron microscopy.
- J Struct Biol - published October 5, 2023
- Jadav N, Velamoor S, Huang D, Cassin L, Hazelton N, Eruera AR, Burga LN, Bostina M
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Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.
- Cell - published October 5, 2023
- Gall-Duncan T, Luo J, Jurkovic CM, Fischer LA, Fujita K, Deshmukh AL, Harding RJ, Tran S, Mehkary M, Li V, Leib DE, Chen R, Tanaka H, Mason AG, Lévesque D, Khan M, Razzaghi M, Prasolava T, Lanni S, Sato N, Caron MC, Panigrahi GB, Wang P, Lau R, Castel AL, Masson JY, Tippett L, Turner C, Spies M, La Spada AR, Campos EI, Curtis MA, Boisvert FM, Faull RLM, Davidson BL, Nakamori M, Okazawa H, Wold MS, Pearson CE
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Dissecting telomerase RNA structural heterogeneity in living human cells with DMS-MaPseq.
- bioRxiv - published October 5, 2023
- Forino NM, Woo JZ, Zaug AJ, Jimenez AG, Cech TR, Rouskin S, Stone MD
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Post-acute immunological and behavioral sequelae in mice after Omicron infection.
- bioRxiv - published October 4, 2023
- Ma T, Suryawanshi RK, Miller SR, Ly KK, Thomas R, Elphick N, Yin K, Luo X, Kaliss N, Chen IP, Montano M, Sreekumar B, Standker L, Münch J, Heath Damron F, Palop JJ, Ott M, Roan NR
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Sialoglycan binding triggers spike opening in a human coronavirus.
- Nature - published October 4, 2023
- Pronker MF, Creutznacher R, Drulyte I, Hulswit RJG, Li Z, van Kuppeveld FJM, Snijder J, Lang Y, Bosch BJ, Boons GJ, Frank M, de Groot RJ, Hurdiss DL
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Dynamic ultrasound molecular-targeted imaging of senescence in evaluation of lapatinib resistance in HER2-positive breast cancer.
- Cancer Med - published October 4, 2023
- Chen X, Li Y, Zhou Z, Zhang Y, Chang L, Gao X, Li Q, Luo H, Westover KD, Zhu J, Wei X
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Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE.
- Nat Commun - published October 4, 2023
- Chongsaritsinsuk J, Steigmeyer AD, Mahoney KE, Rosenfeld MA, Lucas TM, Smith CM, Li A, Ince D, Kearns FL, Battison AS, Hollenhorst MA, Judy Shon D, Tiemeyer KH, Attah V, Kwon C, Bertozzi CR, Ferracane MJ, Lemmon MA, Amaro RE, Malaker SA
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Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive antibody response against diverse coronavirus subgenera.
- Nat Commun - published October 4, 2023
- Hutchinson GB, Abiona OM, Ziwawo CT, Werner AP, Ellis D, Tsybovsky Y, Leist SR, Palandjian C, West A, Fritch EJ, Wang N, Wrapp D, Boyoglu-Barnum S, Ueda G, Baker D, Kanekiyo M, McLellan JS, Baric RS, King NP, Graham BS, Corbett-Helaire KS
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Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1.
- Nat Commun - published October 4, 2023
- Xue J, Zeng W, Han Y, John S, Ottolia M, Jiang Y
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PAM-flexible genome editing with an engineered chimeric Cas9.
- Nat Commun - published October 4, 2023
- Zhao L, Koseki SRT, Silverstein RA, Amrani N, Peng C, Kramme C, Savic N, Pacesa M, Rodríguez TC, Stan T, Tysinger E, Hong L, Yudistyra V, Ponnapati MR, Jacobson JM, Church GM, Jakimo N, Truant R, Jinek M, Kleinstiver BP, Sontheimer EJ, Chatterjee P
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Deciphering Evolutionary Trajectories of Lactate Dehydrogenases Provides New Insights into Allostery.
- Mol Biol Evol - published October 4, 2023
- Robin AY, Brochier-Armanet C, Bertrand Q, Barette C, Girard E, Madern D
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MRT-ModSeq - Rapid Detection of RNA Modifications with MarathonRT.
- J Mol Biol - published October 4, 2023
- Araujo Tavares RC, Mahadeshwar G, Wan H, Pyle AM
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Structure of the bc(1)-cbb(3) respiratory supercomplex from Pseudomonas aeruginosa.
- Proc Natl Acad Sci U S A - published October 3, 2023
- Di Trani JM, Gheorghita AA, Turner M, Brzezinski P, Ädelroth P, Vahidi S, Howell PL, Rubinstein JL
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Bacterial SEAL domains undergo autoproteolysis and function in regulated intramembrane proteolysis.
- Proc Natl Acad Sci U S A - published October 3, 2023
- Brogan AP, Habib C, Hobbs SJ, Kranzusch PJ, Rudner DZ
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Ubiquitination detection techniques.
- Exp Biol Med (Maywood) - published October 3, 2023
- De Silva ARI, Page RC
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Identification of additional mechanistically important residues in the multidrug transporter styMdtM of Salmonella Typhi.
- J Biomol Struct Dyn - published October 3, 2023
- Shaheen A, Tariq A, Ismat F, Naveed H, De Zorzi R, Iqbal M, Storici P, Mirza O, Walz T, Rahman M
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Pseudomonas aeruginosa AlgF is a protein-protein interaction mediator required for acetylation of the alginate exopolysaccharide.
- J Biol Chem - published October 3, 2023
- Low KE, Gheorghita AA, Tammam SD, Whitfield GB, Li YE, Riley LM, Weadge JT, Caldwell SJ, Chong PA, Walvoort MTC, Kitova EN, Klassen JS, Codée JDC, Howell PL
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Development and Validation of Time-to-Event Models to Predict Metastatic Recurrence of Localized Cutaneous Melanoma.
- J Am Acad Dermatol - published October 3, 2023
- Wan G, Leung BW, DeSimone MS, Nguyen N, Rajeh A, Collier MR, Rashdan H, Roster K, Zhou X, Moseley CB, Nirmal AJ, Pelletier RJ, Maliga Z, Marko-Varga G, Németh IB, Tsao H, Asgari MM, Gusev A, Stagner AM, Lian CG, Hurlbert MS, Liu F, Yu KH, Sorger PK, Semenov YR
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Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2.
- Proc Natl Acad Sci U S A - published October 3, 2023
- Alderson TR, Pritišanac I, Kolarić Đ, Moses AM, Forman-Kay JD
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Structural basis for Tpt1-catalyzed 2'-PO(4) transfer from RNA and NADP(H) to NAD().
- Proc Natl Acad Sci U S A - published October 3, 2023
- Jacewicz A, Dantuluri S, Shuman S
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Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering.
- Proc Natl Acad Sci U S A - published October 3, 2023
- Lai Y, Zhao C, Tian Z, Wang C, Fan J, Hu X, Tu J, Li T, Leitz J, Pfuetzner RA, Liu Z, Zhang S, Su Z, Burré J, Li D, Südhof TC, Zhu ZJ, Liu C, Brunger AT, Diao J
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Publisher Correction: R-loop formation and conformational activation mechanisms of Cas9.
- Nature - published October 3, 2023
- Pacesa M, Loeff L, Querques I, Muckenfuss LM, Sawicka M, Jinek M
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Continually recruited naïve T cells contribute to the follicular helper and regulatory T cell pools in germinal centers.
- Nat Commun - published October 3, 2023
- Merkenschlager J, Berz RM, Ramos V, Uhlig M, MacLean AJ, Nowosad CR, Oliveira TY, Nussenzweig MC
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Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.
- Immunity - published October 3, 2023
- Miao R, Jiang C, Chang WY, Zhang H, An J, Ho F, Chen P, Zhang H, Junqueira C, Amgalan D, Liang FG, Zhang J, Evavold CL, Hafner-Bratkovič I, Zhang Z, Fontana P, Xia S, Waldeck-Weiermair M, Pan Y, Michel T, Bar-Peled L, Wu H, Kagan JC, Kitsis RN, Zhang P, Liu X, Lieberman J
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SARS-CoV-2 antibodies from children exhibit broad neutralization and belong to adult public clonotypes.
- Cell Rep Med - published October 3, 2023
- Wall SC, Suryadevara N, Kim C, Shiakolas AR, Holt CM, Irbe EB, Wasdin PT, Suresh YP, Binshtein E, Chen EC, Zost SJ, Canfield E, Crowe JE Jr, Thompson-Arildsen MA, Sheward DJ, Carnahan RH, Georgiev IS
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Crystal Structure of Inhibitor-Bound GII.4 Sydney 2012 Norovirus 3C-Like Protease.
- Viruses - published October 3, 2023
- Eruera AR, McSweeney AM, McKenzie-Goldsmith GM, Opel-Reading HK, Thomas SX, Campbell AC, Stubbing L, Siow A, Hubert JG, Brimble MA, Ward VK, Krause KL
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Structure and assembly of a bacterial gasdermin pore.
- bioRxiv - published October 2, 2023
- Johnson AG, Mayer ML, Schaefer SL, McNamara-Bordewick NK, Hummer G, Kranzusch PJ
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POT1 recruits and regulates CST-Polα/Primase at human telomeres.
- bioRxiv - published October 2, 2023
- Cai SW, Takai H, Walz T, de Lange T
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Project Strengthen: An STEMM-focused career development workshop to prepare underrepresented minority students for graduate school.
- iScience - published October 2, 2023
- Barongan T, Neikirk K, Shao B, Vue N, Spencer EC, Kabugi K, Conley Z, Vang L, Vue M, Vang N, Garza-Lopez E, Crabtree A, Alexander S, Dal A, Beasley HK, Marshall AG, Killion M, Stephens DC, Martinez D, Palavicino-Maggio CB, Jenkins F, Davis J, Damo SM, Morra CN, Murray SA, Vang C, Morton DJ, Vue Z, Shuler H, Hinton A Jr
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Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies.
- bioRxiv - published October 2, 2023
- Ratnapriya S, Pothula KR, Dam KA, Parthasarathy D, Benet HC, Parsons R, Huang X, Sammour S, Janowska K, Harris M, Ahmed S, Sacco S, Sodroski J, Bridges MD, Hubbell WL, Acharya P, Herschhorn A
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Biologically Representative Lipid-Coated Gold Nanoparticles and Phospholipid Vesicles for the Study of Alpha-Synuclein/Membrane Interactions.
- ACS Nano - published October 2, 2023
- McClain SM, Milchberg MH, Rienstra CM, Murphy CJ
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Autosomal dominant neovascular inflammatory vitreoretinopathy with CAPN5 c.731T > C gene mutation; clinical management of a family cohort and review of the literature.
- Ophthalmic Genet - published October 2, 2023
- Tabbaa T, Mehra AA, Kesav NP, Mahajan VB, Swanson RD, Zubricky R, Sobol WM
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Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8.
- Cell - published October 2, 2023
- Zimmerman O, Zimmerman MI, Raju S, Nelson CA, Errico JM, Madden EA, Holmes AC, Hassan AO, VanBlargan LA, Kim AS, Adams LJ, Basore K, Whitener BM, Palakurty S, Davis-Adams HG, Sun C, Gilliland T Jr, Earnest JT, Ma H, Ebel GD, Zmasek C, Scheuermann RH, Klimstra WB, Fremont DH, Diamond MS
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Structural foundation for the role of enterococcal PrgB in conjugation, biofilm formation, and virulence.
- Elife - published October 2, 2023
- Sun WS, Lassinantti L, Järvå M, Schmitt A, Ter Beek J, Berntsson RP
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Exploring Novel HIV-1 Reverse Transcriptase Inhibitors with Drug Resistant Mutants: A Double Mutant Surprise.
- Protein Sci - published October 2, 2023
- Hollander K, Chan AH, Frey KM, Hunker O, Ippolito JA, Spasov KA, Yeh YJ, Jorgensen WL, Ho YC, Anderson KS
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Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor.
- Commun Biol - published October 2, 2023
- Yu X, Abeywickrema P, Bonneux B, Behera I, Anson B, Jacoby E, Fung A, Adhikary S, Bhaumik A, Carbajo RJ, De Bruyn S, Miller R, Patrick A, Pham Q, Piassek M, Verheyen N, Shareef A, Sutto-Ortiz P, Ysebaert N, Van Vlijmen H, Jonckers THM, Herschke F, McLellan JS, Decroly E, Fearns R, Grosse S, Roymans D, Sharma S, Rigaux P, Jin Z
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Organic semiconductor based on N, S-containing Crown Ether enabling Efficient and Stable Perovskite Solar Cells.
- ChemSusChem - published October 2, 2023
- Chen K, Zeng Y, Gao X, Liu X, Zhu L, Wu F
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Discovery, Characterization, and Bioactivity of the Achromonodins: Lasso Peptides Encoded by Achromobacter.
- J Nat Prod - published October 2, 2023
- Carson DV, Zhang Y, So L, Cheung-Lee WL, Cartagena AJ, Darst SA, Link AJ
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Mechanism of histone H2B monoubiquitination by Bre1.
- Nat Struct Mol Biol - published October 2, 2023
- Zhao F, Hicks CW, Wolberger C
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Systematic Characterization of Antibody-Drug Conjugate Targets in Central Nervous System Tumors.
- Neuro Oncol - published October 2, 2023
- Coy S, Lee JS, Chan SJ, Woo T, Jones J, Alexandrescu S, Wen PY, Sorger PK, Ligon KL, Santagata S
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Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo.
- PLoS Pathog - published October 2, 2023
- Kordus SL, Kroh HK, Rodríguez RC, Shrem RA, Peritore-Galve FC, Shupe JA, Wadzinski BE, Lacy DB, Spiller BW
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Previous exposure to Spike-providing parental strains confers neutralizing immunity to XBB lineage and other SARS-CoV-2 recombinants in the context of vaccination.
- Emerg Microbes Infect - published October 2, 2023
- Suryawanshi RK, Taha TY, McCavitt-Malvido M, Silva I, Khalid MM, Syed AM, Chen IP, Saldhi P, Sreekumar B, Montano M, Foresythe K, Tabata T, Renuka Kumar G, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Kojima N, Arellanor T, Bussanich A, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Wang Y, Ghazarian S, Davis G, Rodriguez D, Doudna J, Spraggon L, Chiu CY, Ott M
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Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
- Nucleic Acids Res - published October 2, 2023
- Kefala Stavridi A, Gontier A, Morin V, Frit P, Ropars V, Barboule N, Racca C, Jonchhe S, Morten MJ, Andreani J, Rak A, Legrand P, Bourand-Plantefol A, Hardwick SW, Chirgadze DY, Davey P, De Oliveira TM, Rothenberg E, Britton S, Calsou P, Blundell TL, Varela PF, Chaplin AK, Charbonnier JB
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Author Correction: Real-world COVID-19 vaccine effectiveness against the Omicron BA.2 variant in a SARS-CoV-2 infection-naive population.
- Nat Med - published October 2, 2023
- Lau JJ, Cheng SMS, Leung K, Lee CK, Hachim A, Tsang LCH, Yam KWH, Chaothai S, Kwan KKH, Chai ZYH, Lo THK, Mori M, Wu C, Valkenburg SA, Amarasinghe GK, Lau EHY, Hui DSC, Leung GM, Peiris M, Wu JT
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The role of primary health care in long-term care facilities during the COVID-19 pandemic in 30 European countries: a retrospective descriptive study (Eurodata study).
- Prim Health Care Res Dev - published October 2, 2023
- Guisado-Clavero M, Ares-Blanco S, Serafini A, Del Rio LR, Larrondo IG, Fitzgerald L, Vinker S, van Pottebergh G, Valtonen K, Vaes B, Yilmaz CT, Torzsa P, Tilli P, Sentker T, Seifert B, Saurek-Aleksandrovska N, Sattler M, Petricek G, Petrazzuoli F, Petek D, Perjés Á, López NP, Neves AL, Murauskienė L, Lingner H, Nessler K, Heleno B, Krztoń-Królewiecka A, Kostić M, Korkmaz BÇ, Knežević S, Kirkovski A, Karathanos VT, Jandrić-Kočić M, Ivanna S, Ільков О, Hoffmann K, Hanževački M, Gómez-Johansson M, Gjorgjievski D, Domeyer PJ, Peña MD, Divjak AĆ, Busneag IC, Brutskaya-Stempkovskaya E, Bayen S, Bakola M, Adler L, Assenova R, Astier-Peña MP, Gómez Bravo R
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The directed evolution of NDM-1.
- Antimicrob Agents Chemother - published October 2, 2023
- Thomas CA, Cheng Z, Bethel CR, Hujer AM, Sturgill AM, Onuoha K, Page RC, Bonomo RA, Crowder MW
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In vitro reconstitution of herpes simplex virus 1 fusion identifies low pH as a fusion co-trigger.
- mBio - published October 2, 2023
- Ramirez JM, Calderon-Zavala AC, Balaram A, Heldwein EE
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Correction: Rho family GTPase signaling through type II p21-activated kinases.
- Cell Mol Life Sci - published October 2, 2023
- Chetty AK, Ha BH, Boggon TJ
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Structures of a sperm-specific solute carrier gated by voltage and cAMP.
- Nature - published October 2, 2023
- Kalienkova V, Peter MF, Rheinberger J, Paulino C
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Flexibility and distributive synthesis regulate RNA priming and handoff in human DNA polymerase α-primase.
- J Mol Biol - published October 2, 2023
- Cordoba JJ, Mullins EA, Salay LE, Eichman BF, Chazin WJ
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Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase.
- Eur J Med Chem - published October 2, 2023
- Prucha GR, Henry S, Hollander K, Carter ZJ, Spasov KA, Jorgensen WL, Anderson KS
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General science-technology orientation, specific benefit-risk assessment frame, and public acceptance of gene drive biotechnology.
- Risk Anal - published October 2, 2023
- Liu X, Goldsmith CL, Kang KE, Vedlitz A, Adelman ZN, Buchman LW, Heitman E, Medina RF
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Pseudomonas aeruginosa biofilm exopolysaccharides: Assembly, function, and degradation.
- FEMS Microbiol Rev - published October 2, 2023
- Gheorghita AA, Wozniak DJ, Parsek MR, Howell PL
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GSG1L-containing AMPA receptor complexes are defined by their spatiotemporal expression, native interactome and allosteric sites.
- Nat Commun - published October 2, 2023
- Perozzo AM, Schwenk J, Kamalova A, Nakagawa T, Fakler B, Bowie D
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Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain.
- Mol Cell - published October 2, 2023
- Small GI, Fedorova O, Olinares PDB, Chandanani J, Banerjee A, Choi YJ, Molina H, Chait BT, Darst SA, Campbell EA
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Total infectome investigation of diphtheritic stomatitis in yellow-eyed penguins (Megadyptes antipodes) reveals a novel and abundant megrivirus.
- Vet Microbiol - published October 2, 2023
- Wierenga JR, Grimwood RM, Taylor HS, Hunter S, Argilla LS, Webster T, Lim L, French R, Schultz H, Jorge F, Bostina M, Burga L, Swindells-Wallace P, Holmes EC, McInnes K, Morgan KJ, Geoghegan JL
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Human CD4-Binding Site Antibody Elicited by Polyvalent DNA Prime-Protein Boost Vaccine Neutralizes Cross-Clade Tier-2-HIV Strains.
- Res Sq - published October 2, 2023
- Wang S, Chan KW, Wei D, Ma X, Liu S, Hu G, Park S, Pan R, Gu Y, Nazzari AF, Olia AS, Xu K, Lin BC, Louder MK, Doria-Rose NA, Montefiori D, Seaman MS, Zhou T, Kwong PD, Arthos J, Kong XP, Lu S
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Proteases influence colony aggregation behavior in Vibrio cholerae.
- J Biol Chem - published October 2, 2023
- Detomasi TC, Batka AE, Valastyan JS, Hydorn MA, Craik CS, Bassler BL, Marletta MA
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ADP-ribose contributions to genome stability, and PARP enzyme trapping on sites of DNA damage; paradigm shifts for a coming-of-age modification.
- J Biol Chem - published October 2, 2023
- Rouleau-Turcotte É, Pascal JM
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Structural titration reveals Ca(2+)-dependent conformational landscape of the IP(3) receptor.
- Nat Commun - published October 2, 2023
- Paknejad N, Sapuru V, Hite RK
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Homotypic antibodies target novel E glycoprotein domains after natural DENV 3 infection/vaccination.
- Cell Host Microbe - published October 2, 2023
- Munt JE, Henein S, Adams C, Young E, Hou YJ, Conrad H, Zhu D, Dong S, Kose N, Yount B, Meganck RM, Tse LPV, Kuan G, Balmaseda A, Ricciardi MJ, Watkins DI, Crowe JE Jr, Harris E, DeSilva AM, Baric RS
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An mRNA-based platform for the delivery of pathogen-specific IgA into mucosal secretions.
- Cell Rep Med - published October 2, 2023
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Cryo-electron tomography reveals the structural diversity of cardiac proteins in their cellular context.
- bioRxiv - published October 2, 2023
- Woldeyes RA, Nishiga M, Vander Roest AS, Engel L, Giri P, Montenegro GC, Wu AC, Dunn AR, Spudich JA, Bernstein D, Schmid MF, Wu JC, Chiu W
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Docking for molecules that bind in a symmetric stack with SymDOCK.
- bioRxiv - published October 2, 2023
- Smith MS, Knight IS, Kormos RC, Pepe JG, Kunach P, Diamond MI, Shahmoradian SH, Irwin JJ, DeGrado WF, Shoichet BK
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HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing.
- Viruses - published October 2, 2023
- Lyons DE, Kumar P, Roan NR, Defechereux PA, Feschotte C, Lange UC, Murthy N, Sameshima P, Verdin E, Ake JA, Parsons MS, Nath A, Gianella S, Smith DM, Kallas EG, Villa TJ, Strange R, Mwesigwa B, Furler O'Brien RL, Nixon DF, Ndhlovu LC, Valente ST, Ott M
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tRNA m(1)G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10.
- bioRxiv - published October 1, 2023
- Strassler SE, Bowles IE, Krishnamohan A, Kim H, Edgington CB, Kuiper EG, Hancock CJ, Comstock LR, Jackman JE, Conn GL
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Factorization and pseudofactorization of weighted graphs.
- Discrete Appl Math - published October 1, 2023
- Sheridan K, Berleant J, Bathe M, Condon A, Williams VV
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Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes.
- bioRxiv - published October 1, 2023
- Shao B, Killion M, Oliver A, Vang C, Zeleke F, Neikirk K, Vue Z, Garza-Lopez E, Shao JQ, Mungai M, Lam J, Williams Q, Altamura CT, Whiteside A, Kabugi K, McKenzie J, Koh A, Scudese E, Vang L, Marshall AG, Crabtree A, Tanghal JI, Stephens D, Koh HJ, Jenkins BC, Murray SA, Cooper AT, Williams C, Damo SM, McReynolds MR, Gaddy JA, Wanjalla CN, Beasley HK, Hinton A Jr
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Structure of the preholoproteasome reveals late steps in proteasome core particle biogenesis.
- Nat Struct Mol Biol - published October 1, 2023
- Walsh RM Jr, Rawson S, Schnell HM, Velez B, Rajakumar T, Hanna J
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Harnessing citizen science in health promotion: perspectives of policy and practice stakeholders in Australia.
- Health Promot Int - published October 1, 2023
- Laird Y, Marks L, Smith BJ, Walker P, Garvey K, Jose K, O'Rourke S, Pontifex K, Wardle K, Rowbotham S
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Dosimetric Analysis of CBCT-Based Weekly Online Adaptive Radiotherapy for Locally Advanced Non-Small Cell Lung Cancer.
- Int J Radiat Oncol Biol Phys - published October 1, 2023
- Li R, Montalvo SK, Zhuang T, Parsons DDM, Zhong X, Chen L, Iqbal Z, Kim H, Hrycushko BA, Westover KD, Zhang Y, Cai B, Lin MH, Iyengar P
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Tracking Changes in Global Longitudinal Strain in Lung Cancer Patients Receiving Thoracic Radiation.
- Int J Radiat Oncol Biol Phys - published October 1, 2023
- Montalvo SK, Lue B, Kakadiaris E, Zhang-Velten ER, Aliru ML, Westover KD, Iyengar P, Timmerman RD, Zaha V, Vallabhaneni S, Zhang K, Chandra A, Alluri PG
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Predictive Factors for Response to Adaptive Therapy in Thoracic Stereotactic Ablative Radiotherapy.
- Int J Radiat Oncol Biol Phys - published October 1, 2023
- Montalvo SK, Arbab M, Gonzalez Y, Lin MH, Parsons DDM, Zhuang T, Cai B, Pompos A, Hannan R, Westover KD, Zhang Y, Timmerman RD, Iyengar P
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Quality and Safety Considerations in Image Guided Radiation Therapy: An ASTRO Safety White Paper Update.
- Int J Radiat Oncol Biol Phys - published October 1, 2023
- Qi X, Albuquerque KV, Bailey S, Dawes S, Kashani R, Li H, Mak RH, Mundt AJ Jr, Sio TTW
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Could Poor Outcomes for Patients with Limited Lung Function Treated with SAbR Necessitate PULSAR?
- Int J Radiat Oncol Biol Phys - published October 1, 2023
- Aliru ML, Zhang Y, Westover KD, Timmerman RD, Iyengar P
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Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A.
- Nat Commun - published October 1, 2023
- Harjes S, Kurup HM, Rieffer AE, Bayarjargal M, Filitcheva J, Su Y, Hale TK, Filichev VV, Harjes E, Harris RS, Jameson GB
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Apoptotic stress causes mtDNA release during senescence and drives the SASP.
- Nature - published October 1, 2023
- Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF
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Asymmetric gating of a human hetero-pentameric glycine receptor.
- Nat Commun - published October 1, 2023
- Liu X, Wang W
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A sensor complements the steric gate when DNA polymerase ϵ discriminates ribonucleotides.
- Nucleic Acids Res - published October 1, 2023
- Parkash V, Kulkarni Y, Bylund GO, Osterman P, Kamerlin SCL, Johansson E
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Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor.
- Cell Chem Biol - published October 1, 2023
- Bhattacharjee D, Bakar J, Chitnis SP, Sausville EL, Ashtekar KD, Mendelson BE, Long K, Smith JC, Heppner DE, Sheltzer JM
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Rare antibody phage isolation and discrimination (RAPID) biopanning enables identification of high-affinity antibodies against challenging targets.
- Commun Biol - published October 1, 2023
- Chung DH, Kong S, Young NJ, Chuo SW, Shiah JV, Connelly EJ, Rohweder PJ, Born A, Manglik A, Grandis JR, Johnson DE, Craik CS
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Experimental phasing opportunities for macromolecular crystallography at very long wavelengths.
- Commun Chem - published October 1, 2023
- El Omari K, Duman R, Mykhaylyk V, Orr CM, Latimer-Smith M, Winter G, Grama V, Qu F, Bountra K, Kwong HS, Romano M, Reis RI, Vogeley L, Vecchia L, Owen CD, Wittmann S, Renner M, Senda M, Matsugaki N, Kawano Y, Bowden TA, Moraes I, Grimes JM, Mancini EJ, Walsh MA, Guzzo CR, Owens RJ, Jones EY, Brown DG, Stuart DI, Beis K, Wagner A
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DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma.
- Cell Death Dis - published October 1, 2023
- Strubel A, Münick P, Hartmann O, Chaikuad A, Dreier B, Schaefer JV, Gebel J, Osterburg C, Tuppi M, Schäfer B, Buck V, Rosenfeldt M, Knapp S, Plückthun A, Diefenbacher ME, Dötsch V
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Plasmodium falciparum exploits CD44 as a co-receptor for erythrocyte invasion.
- Blood - published October 1, 2023
- Baro B, Kim CY, Lin C, Kongsomboonvech AK, Tetard M, Peterson NA, Salinas ND, Tolia NH, Egan ES
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Structural basis for triacylglyceride extraction from mycobacterial inner membrane by MFS transporter Rv1410.
- Nat Commun - published October 1, 2023
- Remm S, De Vecchis D, Schöppe J, Hutter CAJ, Gonda I, Hohl M, Newstead S, Schäfer LV, Seeger MA
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Integrative solution structure of PTBP1-IRES complex reveals strong compaction and ordering with residual conformational flexibility.
- Nat Commun - published October 1, 2023
- Dorn G, Gmeiner C, de Vries T, Dedic E, Novakovic M, Damberger FF, Maris C, Finol E, Sarnowski CP, Kohlbrecher J, Welsh TJ, Bolisetty S, Mezzenga R, Aebersold R, Leitner A, Yulikov M, Jeschke G, Allain FH
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Identifying quantitatively differential chromosomal compartmentalization changes and their biological significance from Hi-C data using DARIC.
- BMC Genomics - published October 1, 2023
- Kai Y, Liu N, Orkin SH, Yuan GC
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Recent developments in catalysis and inhibition of the Jumonji histone demethylases.
- Curr Opin Struct Biol - published October 1, 2023
- Sarah L, Fujimori DG
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Bifidobacteria metabolize lactulose to optimize gut metabolites and prevent systemic infection in patients with liver disease.
- Nat Microbiol - published October 1, 2023
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Pervasive, conserved secondary structure in highly charged protein regions.
- PLoS Comput Biol - published October 1, 2023
- Triandafillou CG, Pan RW, Dinner AR, Drummond DA
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Structural basis of the American mink ACE2 binding by Y453F trimeric spike glycoproteins of SARS-CoV-2.
- J Med Virol - published October 1, 2023
- Ahn H, Calderon BM, Fan X, Gao Y, Horgan NL, Jiang N, Blohm DS, Hossain J, Rayyan NWK, Osman SH, Lin X, Currier M, Steel J, Wentworth DE, Zhou B, Liang B
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Landscape of Clinical Resistance Mechanisms to FGFR Inhibitors in FGFR2-Altered Cholangiocarcinoma.
- Clin Cancer Res - published October 1, 2023
- Wu Q, Ellis H, Siravegna G, Michel AG, Norden BL, Fece de la Cruz F, Balasooriya ER, Zhen Y, Silveira VS, Che J, Corcoran RB, Bardeesy N
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Synthesis and Biophysical Studies of High-Affinity Morpholino Oligomers Containing G-Clamp Analogs.
- J Org Chem - published October 1, 2023
- Das A, Ghosh A, Kundu J, Egli M, Manoharan M, Sinha S
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The Tubulin Code, from Molecules to Health and Disease.
- Annu Rev Cell Dev Biol - published October 1, 2023
- McKenna ED, Sarbanes SL, Cummings SW, Roll-Mecak A
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HTS discovery of PARP1-HPF1 complex inhibitors in cancer.
- SLAS Discov - published October 1, 2023
- Kellett T, Noor R, Zhou Q, Esquer H, Sala R, Stojanovic P, Rudolph J, Luger K, LaBarbera DV
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Experimental evolution of Pseudomonas aeruginosa to colistin in spatially confined microdroplets identifies evolutionary trajectories consistent with adaptation in microaerobic lung environments.
- mBio - published October 1, 2023
- Disney-McKeethen S, Seo S, Mehta H, Ghosh K, Shamoo Y
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PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly.
- Mol Cell - published October 1, 2023
- Chou MC, Wang YH, Chen FY, Kung CY, Wu KP, Kuo JC, Chan SJ, Cheng ML, Lin CY, Chou YC, Ho MC, Firestine S, Huang JR, Chen RH
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Tn antigen interactions of macrophage galactose-type lectin (MGL) in immune function and disease.
- Glycobiology - published October 1, 2023
- Tumoglu B, Keelaghan A, Avci FY
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Distinct Conformations of Mirabegron Determined by MicroED.
- Adv Sci (Weinh) - published October 1, 2023
- Lin J, Unge J, Gonen T
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Developing a Prototype Pathogen Plan and Research Priorities for the Alphaviruses.
- J Infect Dis - published October 1, 2023
- Powers AM, Williamson LE, Carnahan RH, Crowe JE Jr, Hyde JL, Jonsson CB, Nasar F, Weaver SC
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Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys.
- J Infect - published October 1, 2023
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Defining the Conformational Ensembles Associated with Ligand Binding to Cyclooxygenase-2.
- Biochemistry - published October 1, 2023
- Dong L, Malkowski MG
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The SMN complex drives structural changes in human snRNAs to enable snRNP assembly.
- Nat Commun - published October 1, 2023
- Pánek J, Roithová A, Radivojević N, Sýkora M, Prusty AB, Huston N, Wan H, Pyle AM, Fischer U, Staněk D
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A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response.
- Nat Cell Biol - published October 1, 2023
- Subramanian A, Wang L, Moss T, Voorhies M, Sangwan S, Stevenson E, Pulido EH, Kwok S, Chalkley RJ, Li KH, Krogan NJ, Swaney DL, Burlingame AL, Floor SN, Sil A, Walter P, Mukherjee S
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Discovery of Nanosota-2, -3, and -4 as super potent and broad-spectrum therapeutic nanobody candidates against COVID-19.
- J Virol - published October 1, 2023
- Ye G, Pan R, Bu F, Zheng J, Mendoza A, Wen W, Du L, Spiller B, Wadzinski BE, Liu B, Perlman S, Li F
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Blocking of ebolavirus spread through intercellular connections by an MPER-specific antibody depends on BST2/tetherin.
- Cell Rep - published October 1, 2023
- Santos RI, Ilinykh PA, Pietzsch CA, Ronk AJ, Huang K, Kuzmina NA, Zhou F, Crowe JE, Bukreyev A
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Abl2 repairs microtubules and phase separates with tubulin to promote microtubule nucleation.
- Curr Biol - published October 1, 2023
- Duan D, Lyu W, Chai P, Ma S, Wu K, Wu C, Xiong Y, Sestan N, Zhang K, Koleske AJ
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Assembly of SARS-CoV-2 ribonucleosomes by truncated N* variant of the nucleocapsid protein.
- J Biol Chem - published October 1, 2023
- Adly AN, Bi M, Carlson CR, Syed AM, Ciling A, Doudna JA, Cheng Y, Morgan DO
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Promotion of neuroinflammation by the glymphatic system: a new insight into ethanol extracts from Alisma orientale in alleviating obesity-associated cognitive impairment.
- Phytomedicine - published October 1, 2023
- Zhan M, Liu X, Xia X, Yang Y, Xie Y, Zhang L, Lin C, Zhu J, Ding W, Xu S
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De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking.
- Cell - published October 1, 2023
- Chen Z, Shiozaki M, Haas KM, Skinner WM, Zhao S, Guo C, Polacco BJ, Yu Z, Krogan NJ, Lishko PV, Kaake RM, Vale RD, Agard DA
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Secretory Leukocyte Protease Inhibitor Protects Against Severe Urinary Tract Infection in Mice.
- bioRxiv - published October 1, 2023
- Rosen AL, Lint MA, Voelker DH, Gilbert NM, Tomera CP, Santiago-Borges J, Wallace MA, Hannan TJ, Burnham CD, Hultgren SJ, Kau AL
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Activation of automethylated PRC2 by dimerization on chromatin.
- bioRxiv - published October 1, 2023
- Sauer PV, Pavlenko E, Cookis T, Zirden LC, Renn J, Singhal A, Hunold P, Hoehne MN, van Ray O, Hänsel-Hertsch R, Sanbonmatsu KY, Nogales E, Poepsel S
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ASCT2 is the primary serine transporter in cancer cells.
- bioRxiv - published October 1, 2023
- Conger KO, Chidley C, Ozgurses ME, Zhao H, Kim Y, Semina SE, Burns P, Rawat V, Sheldon R, Ben-Sahra I, Frasor J, Sorger PK, DeNicola GM, Coloff JL
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Exploration of the Tunability of BRD4 Degradation by DCAF16 Trans-labelling Covalent Glues.
- bioRxiv - published October 1, 2023
- Hassan MM, Li YD, Ma MW, Teng M, Byun WS, Puvar K, Lumpkin R, Sandoval B, Rutter JC, Jin CY, Wang MY, Xu S, Schmoker AM, Cheong H, Groendyke BJ, Qi J, Fischer ES, Ebert BL, Gray NS
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Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly.
- Mol Cell - published October 1, 2023
- Keidel A, Kögel A, Reichelt P, Kowalinski E, Schäfer IB, Conti E
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Architecture and rearrangements of a sperm-specific Na(+)/H(+) exchanger.
- Res Sq - published October 1, 2023
- Chowdhury S, Pal K
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Red Blood Cell-Derived Extracellular Vesicles: An Overview of Current Research Progress, Challenges, and Opportunities.
- Biomedicines - published October 1, 2023
- Ma SR, Xia HF, Gong P, Yu ZL
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ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer.
- bioRxiv - published October 1, 2023
- Qian C, Yang Q, Rotinen M, Huang R, Kim H, Gallent B, Yan Y, Cadaneanu RM, Zhang B, Kaochar S, Freedland SJ, Posadas EM, Ellis L, Vizio DD, Morrissey C, Nelson PS, Brady L, Murali R, Campbell MJ, Yang W, Knudsen BS, Mostaghel EA, Ye H, Garraway IP, You S, Freeman MR
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Membrane Lipids Augment Cell Envelope Stress Signaling and Resistance to Antibiotics and Antimicrobial Peptides in Enterococcus faecalis.
- bioRxiv - published October 1, 2023
- Miller WR, Nguyen A, Singh KV, Rizvi S, Khan A, Erickson SG, Egge SL, Cruz M, Dinh AQ, Diaz L, Zhang R, Xu L, Garsin DA, Shamoo Y, Arias CA
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Development of covalent chemogenetic K(2P) channel activators.
- bioRxiv - published October 1, 2023
- Deal PE, Lee H, Mondal A, Lolicato M, de Mendonca PRF, Black H, El-Hilali X, Bryant C, Isacoff EY, Renslo AR, Minor DL Jr