Member Publications

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130 Member Publications for December 2021

Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy.
1. Front Immunol - published December 31, 2021
2. Ye Z, Shi Y, Lees-Miller SP, Tainer JA
Decoding Cancer Variants of Unknown Significance for Helicase-Nuclease-RPA Complexes Orchestrating DNA Repair During Transcription and Replication.
1. Front Mol Biosci - published December 30, 2021
2. Tsutakawa SE, Bacolla A, Katsonis P, Bralić A, Hamdan SM, Lichtarge O, Tainer JA, Tsai CL
Rapid discovery of diverse neutralizing SARS-CoV-2 antibodies from large-scale synthetic phage libraries.
1. MAbs - published December 30, 2021
2. Yuan TZ, Garg P, Wang L, Willis JR, Kwan E, Hernandez AGL, Tuscano E, Sever EN, Keane E, Soto C, Mucker EM, Fouch ME, Davidson E, Doranz BJ, Kailasan S, Aman MJ, Li H, Hooper JW, Saphire EO, Crowe JE, Liu Q, Axelrod F, Sato AK
The aryl hydrocarbon receptor as a model PAS sensor.
1. Toxicol Rep - published December 24, 2021
2. Vazquez-Rivera E, Rojas B, Parrott JC, Shen AL, Xing Y, Carney PR, Bradfield CA
Early Drug Discovery and Development of Novel Cancer Therapeutics Targeting DNA Polymerase Eta (POLH).
1. Front Oncol - published December 13, 2021
2. Wilson DM, Duncton MAJ, Chang C, Lee Luo C, Georgiadis TM, Pellicena P, Deacon AM, Gao Y, Das D
Single-molecule imaging of von Willebrand factor reveals tension-dependent self-association.
1. Blood - published December 9, 2021
2. Fu H, Jiang Y, Wong WP, Springer TA
Structural and Functional Characterization of Fosfomycin Resistance Conferred by FosB from Enterococcus faecium.
1. Protein Sci - published December 9, 2021
2. Wiltsie V, Travis S, Shay MR, Simmons Z, Frantom P, Thompson MK
Insulin and glucose metabolism with olanzapine and a combination of olanzapine and samidorphan: exploratory phase 1 results in healthy volunteers.
1. Neuropsychopharmacology - published December 9, 2021
2. Toledo FGS, Martin WF, Morrow L, Beysen C, Bajorunas D, Jiang Y, Silverman BL, McDonnell D, Namchuk MN, Newcomer JW, Graham C
A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus.
1. Nat Med - published December 9, 2021
2. August A, Attarwala HZ, Himansu S, Kalidindi S, Lu S, Pajon R, Han S, Lecerf JM, Tomassini JE, Hard M, Ptaszek LM, Crowe JE, Zaks T
Cloud computing platforms to support cryo-EM structure determination.
1. Trends Biochem Sci - published December 9, 2021
2. Li Y, Cianfrocco MA
Attenuated response to SARS-CoV-2 vaccine in patients with asymptomatic precursor stages of multiple myeloma and Waldenstrom macroglobulinemia.
1. Cancer Cell - published December 9, 2021
2. Konishi Y, Sklavenitis-Pistofidis R, Yue H, Ferrari F, Redd RA, Lightbody ED, Russo M, Perry J, Horowitz E, Justis AV, Shayegh NA, Savell A, Prescott J, Varmeh S, Nowak RP, Hamilton M, Auclair D, Marinac CR, Trippa L, Fischer ES, Ghobrial IM
Bisphosphate nucleotidase 2 (BPNT2), a molecular target of lithium, regulates chondroitin sulfation patterns in the cerebral cortex and hippocampus.
1. Adv Biol Regul - published December 9, 2021
2. Eisele BS, Wu AJ, Luka Z, Hale AT, York JD
Stimulation of the steady state ATPase kinetics of the ABC exporter NaAtm1 by a transported substrate GSSG.
1. Protein Sci - published December 8, 2021
2. Fan C, Rees DC
Structures of the σ₂ receptor enable docking for bioactive ligand discovery.
1. Nature - published December 8, 2021
2. Alon A, Lyu J, Braz JM, Tummino TA, Craik V, O'Meara MJ, Webb CM, Radchenko DS, Moroz YS, Huang XP, Liu Y, Roth BL, Irwin JJ, Basbaum AI, Shoichet BK, Kruse AC
Structure and mechanism of the SGLT family of glucose transporters.
1. Nature - published December 8, 2021
2. Han L, Qu Q, Aydin D, Panova O, Robertson MJ, Xu Y, Dror RO, Skiniotis G, Feng L
Standardized two-step testing of antibody activity in COVID-19 convalescent plasma.
1. iScience - published December 8, 2021
2. Gilchuk P, Thomsen I, Yoder S, Brady E, Chappell JD, Stevens LJ, Denison MR, Sutton RE, Chen RE, VanBlargan LA, Suryadevara N, Zost SJ, Schmitz J, Pulley JM, Diamond MS, Rhoads JP, Bernard GR, Self WH, Rice TW, Wheeler AP, Crowe JE Jr, Carnahan RH
SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity.
1. Cell Rep - published December 8, 2021
2. Joyce MG, Chen WH, Sankhala RS, Hajduczki A, Thomas PV, Choe M, Martinez EJ, Chang WC, Peterson CE, Morrison EB, Smith C, Chen RE, Ahmed A, Wieczorek L, Anderson A, Case JB, Li Y, Oertel T, Rosado L, Ganesh A, Whalen C, Carmen JM, Mendez-Rivera L, Karch CP, Gohain N, Villar Z, McCurdy D, Beck Z, Kim J, Shrivastava S, Jobe O, Dussupt V, Molnar S, Tran U, Kannadka CB, Soman S, Kuklis C, Zemil M, Khanh H, Wu W, Cole MA, Duso DK, Kummer LW, Lang TJ, Muncil SE, Currier JR, Krebs SJ, Polonis VR, Rajan S, McTamney PM, Esser MT, Reiley WW, Rolland M, de Val N, Diamond MS, Gromowski GD, Matyas GR, Rao M, Michael NL, Modjarrad K
Voltage-gating and cytosolic Ca²⁺ activation mechanisms of Arabidopsis two-pore channel AtTPC1.
1. Proc Natl Acad Sci U S A - published December 7, 2021
2. Ye F, Xu L, Li X, Zeng W, Gan N, Zhao C, Yang W, Jiang Y, Guo J
CHARMM-GUI Drude prepper for molecular dynamics simulation using the classical Drude polarizable force field.
1. J Comput Chem - published December 7, 2021
2. Kognole AA, Lee J, Park SJ, Jo S, Chatterjee P, Lemkul JA, Huang J, MacKerell AD Jr, Im W
Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape.
1. Elife - published December 7, 2021
2. Mast FD, Fridy PC, Ketaren NE, Wang J, Jacobs EY, Olivier JP, Sanyal T, Molloy KR, Schmidt F, Rutkowska M, Weisblum Y, Rich LM, Vanderwall ER, Dambrauskas N, Vigdorovich V, Keegan S, Jiler JB, Stein ME, Olinares PDB, Herlands L, Hatziioannou T, Sather DN, Debley JS, Fenyö D, Sali A, Bieniasz PD, Aitchison JD, Chait BT, Rout MP
Linking function to global and local dynamics in an elevator-type transporter.
1. Proc Natl Acad Sci U S A - published December 7, 2021
2. Ciftci D, Martens C, Ghani VG, Blanchard SC, Politis A, Huysmans GHM, Boudker O
Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B.
1. Nat Commun - published December 7, 2021
2. Schoof M, Wang L, Cogan JZ, Lawrence RE, Boone M, Wuerth JD, Frost A, Walter P
Structural parasitology of the malaria parasite Plasmodium falciparum.
1. Trends Biochem Sci - published December 7, 2021
2. Anton L, Cobb DW, Ho CM
Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis.
1. J Exp Med - published December 6, 2021
2. Chen J, Jing H, Martin-Nalda A, Bastard P, Rivière JG, Liu Z, Colobran R, Lee D, Tung W, Manry J, Hasek M, Boucherit S, Lorenzo L, Rozenberg F, Aubart M, Abel L, Su HC, Soler Palacin P, Casanova JL, Zhang SY
Krabbe Disease: Prospects of Finding a Cure Using AAV Gene Therapy.
1. Front Med (Lausanne) - published December 6, 2021
2. Nasir G, Chopra R, Elwood F, Ahmed SS
Heterophilic and homophilic cadherin interactions in intestinal intermicrovillar links are species dependent.
1. PLoS Biol - published December 6, 2021
2. Gray ME, Johnson ZR, Modak D, Tamilselvan E, Tyska MJ, Sotomayor M
T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes.
1. Nat Biotechnol - published December 6, 2021
2. Ali M, Giannakopoulou E, Li Y, Lehander M, Virding Culleton S, Yang W, Knetter C, Odabasi MC, Bollineni RC, Yang X, Foldvari Z, Böschen ML, Taraldsrud E, Strønen E, Toebes M, Hillen A, Mazzi S, de Ru AH, Janssen GMC, Kolstad A, Tjønnfjord GE, Lie BA, Griffioen M, Lehmann S, Osnes LT, Buechner J, Garcia KC, Schumacher TN, van Veelen PA, Leisegang M, Jacobsen SEW, Woll P, Olweus J
Viral proteases: Structure, mechanism and inhibition.
1. Enzymes - published December 4, 2021
2. Zephyr J, Kurt Yilmaz N, Schiffer CA
De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex.
1. Sci Adv - published December 3, 2021
2. Chen KE, Guo Q, Hill TA, Cui Y, Kendall AK, Yang Z, Hall RJ, Healy MD, Sacharz J, Norwood SJ, Fonseka S, Xie B, Reid RC, Leneva N, Parton RG, Ghai R, Stroud DA, Fairlie DP, Suga H, Jackson LP, Teasdale RD, Passioura T, Collins BM
Transcriptional control of mycobacterial DNA damage response by sigma adaptation.
1. Sci Adv - published December 3, 2021
2. Müller AU, Kummer E, Schilling CM, Ban N, Weber-Ban E
Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice.
1. Sci Adv - published December 3, 2021
2. Mabrouk MT, Chiem K, Rujas E, Huang WC, Jahagirdar D, Quinn B, Surendran Nair M, Nissly RH, Cavener VS, Boyle NR, Sornberger TA, Kuchipudi SV, Ortega J, Julien JP, Martinez-Sobrido L, Lovell J
Socioeconomic and demographic factors in the diagnosis and treatment of Chiari malformation type I and syringomyelia.
1. J Neurosurg Pediatr - published December 3, 2021
2. Akbari SHA, Rizvi AA, CreveCoeur TS, Han RH, Greenberg JK, Torner J, Brockmeyer DL, Wellons JC, Leonard JR, Mangano FT, Johnston JM, Shah MN, Iskandar BJ, Ahmed R, Tuite GF, Kaufman BA, Daniels DJ, Jackson EM, Grant GA, Powers AK, Couture DE, Adelson PD, Alden TD, Aldana PR, Anderson RCE, Selden NR, Bierbrauer K, Boydston W, Chern JJ, Whitehead WE, Dauser RC, Ellenbogen RG, Ojemann JG, Fuchs HE, Guillaume DJ, Hankinson TC, O'Neill BR, Iantosca M, Oakes WJ, Keating RF, Klimo P, Muhlbauer MS, McComb JG, Menezes AH, Khan NR, Niazi TN, Ragheb J, Shannon CN, Smith JL, Ackerman LL, Jea AH, Maher CO, Narayan P, Albert GW, Stone SSD, Baird LC, Gross NL, Durham SR, Greene S, McKinstry RC, Shimony JS, Strahle JM, Smyth MD, Dacey RG, Park TS, Limbrick DD
Attenuation of NLRP3 Inflammasome Activation by Indirubin-Derived PROTAC Targeting HDAC6.
1. ACS Chem Biol - published December 3, 2021
2. Cao Z, Gu Z, Lin S, Chen D, Wang J, Zhao Y, Li Y, Liu T, Li Y, Wang Y, Lin H, He B
Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex.
1. Nat Commun - published December 3, 2021
2. Pennington LF, Gasser P, Kleinboelting S, Zhang C, Skiniotis G, Eggel A, Jardetzky TS
The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target.
1. Cell Death Differ - published December 3, 2021
2. Rona G, Zeke A, Miwatani-Minter B, de Vries M, Kaur R, Schinlever A, Garcia SF, Goldberg HV, Wang H, Hinds TR, Bailly F, Zheng N, Cotelle P, Desmaële D, Landau NR, Dittmann M, Pagano M
DeepRank: a deep learning framework for data mining 3D protein-protein interfaces.
1. Nat Commun - published December 3, 2021
2. Renaud N, Geng C, Georgievska S, Ambrosetti F, Ridder L, Marzella DF, Réau MF, Bonvin AMJJ, Xue LC
The role of the N-terminal amphipathic helix (N-AH) in bacterial YidC: Insights from functional studies, the crystal structure and molecular dynamics simulations.
1. Biochim Biophys Acta Biomembr - published December 3, 2021
2. Nass KJ, Ilie IM, Saller MJ, Driessen AJM, Caflisch A, Kammerer RA, Li X
Structure-activity relationships at a nucleobase-stacking tryptophan required for chemomechanical coupling in the DNA resecting motor-nuclease AdnAB.
1. Nucleic Acids Res - published December 3, 2021
2. Warren GM, Meir A, Wang J, Patel DJ, Greene EC, Shuman S
Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination.
1. Nucleic Acids Res - published December 3, 2021
2. Garg A, Shuman S, Schwer B
Bak Core Dimer Focusses Triacylglycerides in the Membrane.
1. Biophys J - published December 3, 2021
2. Smith NA, Wardak AZ, Cowan AD, Colman PM, Czabotar PE, Smith BJ
Stakeholder Views on Engagement, Trust, Performance, and Risk Considerations About Use of Gene Drive Technology in Agricultural Pest Management.
1. Health Secur - published December 3, 2021
2. Goldsmith CL, Kang KE, Heitman E, Adelman ZN, Buchman LW, Kerns D, Liu X, Medina RF, Vedlitz A
Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron.
1. Nature - published December 3, 2021
2. Carreño JM, Alshammary H, Tcheou J, Singh G, Raskin A, Kawabata H, Sominsky L, Clark J, Adelsberg DC, Bielak D, Gonzalez-Reiche AS, Dambrauskas N, Vigdorovich V, PSP/PARIS Study Group., Srivastava K, Sather DN, Sordillo EM, Bajic G, van Bakel H, Simon V, Krammer F
Epistasis at the SARS-CoV-2 RBD Interface and the Propitiously Boring Implications for Vaccine Escape.
1. bioRxiv - published December 2, 2021
2. Rochman ND, Faure G, Wolf YI, Freddolino PL, Zhang F, Koonin EV
Minor Alterations in Core Promoter Element Positioning Reveal Functional Plasticity of a Bacterial Transcription Factor.
1. mBio - published December 2, 2021
2. Chowdhury WP, Satyshur KA, Keck JL, Kiley PJ
Low affinity integrin states have faster ligand binding kinetics than the high affinity state.
1. Elife - published December 2, 2021
2. Li J, Yan J, Springer TA
Molecular architecture of the human tRNA ligase complex.
1. Elife - published December 2, 2021
2. Kroupova A, Ackle F, Asanović I, Weitzer S, Boneberg FM, Faini M, Leitner A, Chui A, Aebersold R, Martinez J, Jinek M
Discovery and Optimization of a Novel Series of Competitive and Central Nervous System-Penetrant Protease-Activated Receptor 4 (PAR4) Inhibitors.
1. ACS Chem Neurosci - published December 2, 2021
2. Bertron JL, Duvernay MT, Mitchell SG, Smith ST, Maeng JG, Blobaum AL, Davis DC, Meiler J, Hamm HE, Lindsley CW
ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function.
1. Commun Biol - published December 2, 2021
2. Cortés Sanchón A, Santhosh Kumar H, Mantovani M, Osinnii I, Mateos JM, Kaech A, Shcherbakov D, Akbergenov R, Böttger EC
Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity.
1. Nat Commun - published December 2, 2021
2. Kouba T, Vogel D, Thorkelsson SR, Quemin ERJ, Williams HM, Milewski M, Busch C, Günther S, Grünewald K, Rosenthal M, Cusack S
Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.
1. Nat Genet - published December 2, 2021
2. Ito T, Young MJ, Li R, Jain S, Wernitznig A, Krill-Burger JM, Lemke CT, Monducci D, Rodriguez DJ, Chang L, Dutta S, Pal D, Paolella BR, Rothberg MV, Root DE, Johannessen CM, Parida L, Getz G, Vazquez F, Doench JG, Zamanighomi M, Sellers WR
Symmetric activation and modulation of the human calcium-sensing receptor.
1. Proc Natl Acad Sci U S A - published December 2, 2021
2. Park J, Zuo H, Frangaj A, Fu Z, Yen LY, Zhang Z, Mosyak L, Slavkovich VN, Liu J, Ray KM, Cao B, Vallese F, Geng Y, Chen S, Grassucci R, Dandey VP, Tan YZ, Eng E, Lee Y, Kloss B, Liu Z, Hendrickson WA, Potter CS, Carragher B, Graziano J, Conigrave AD, Frank J, Clarke OB, Fan QR
Elusive structure of mammalian DGKs.
1. Adv Biol Regul - published December 2, 2021
2. Ma Q, Srinivasan L, Gabelli SB, Raben DM
Regulation of MLL1 Methyltransferase Activity in Two Distinct Nucleosome Binding Modes.
1. Biochemistry - published December 2, 2021
2. Ayoub A, Park SH, Lee YT, Cho US, Dou Y
Viral RNA N6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus.
1. PLoS Pathog - published December 2, 2021
2. Xue M, Zhang Y, Wang H, Kairis EL, Lu M, Ahmad S, Attia Z, Harder O, Zhang Z, Wei J, Chen P, Gao Y, Peeples ME, Sharma A, Boyaka P, He C, Hur S, Niewiesk S, Li J
Enzymology and Dynamics by Cryogenic Electron Microscopy.
1. Annu Rev Biophys - published December 2, 2021
2. Tsai MD, Wu WJ, Ho MC
Chaplain Leadership During COVID-19: An International Expert Panel.
1. J Pastoral Care Counsel - published December 2, 2021
2. Szilagyi C, Vandenhoeck A, Best MC, Desjardins CM, Drummond DA, Fitchett G, Harrison S, Haythorn T, Holmes C, Muthert H, Nuzum D, Verhoef JHA, Willander E
4-Deoxy-4-fluoro-GalNAz (4FGalNAz) Is a Metabolic Chemical Reporter of O-GlcNAc Modifications, Highlighting the Notable Substrate Flexibility of O-GlcNAc Transferase.
1. ACS Chem Biol - published December 2, 2021
2. Jackson EG, Cutolo G, Yang B, Yarravarapu N, Burns MWN, Bineva-Todd G, Roustan C, Thoden JB, Lin-Jones HM, van Kuppevelt TH, Holden HM, Schumann B, Kohler JJ, Woo CM, Pratt MR
A counter-enzyme complex regulates glutamate metabolism in Bacillus subtilis.
1. Nat Chem Biol - published December 2, 2021
2. Jayaraman V, Lee DJ, Elad N, Vimer S, Sharon M, Fraser JS, Tawfik DS
Computational investigation of the impact of core sequence on immobile DNA four-way junction structure and dynamics.
1. Nucleic Acids Res - published December 2, 2021
2. Adendorff MR, Tang GQ, Millar DP, Bathe M, Bricker WP
A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia.
1. Sci Transl Med - published December 2, 2021
2. Zhang Q, Hresko ME, Picton LK, Su L, Hollander MJ, Nunez-Cruz S, Zhang Z, Assenmacher CA, Sockolosky JT, Garcia KC, Milone MC
Overcoming IMiD Resistance in T-cell Lymphomas Through Potent Degradation of ZFP91 and IKZF1.
1. Blood - published December 2, 2021
2. Wu W, Nelson G, Koch R, Donovan KA, Nowak RP, Heavican-Foral TB, Nirmal AJ, Liu H, Yang L, Duffy J, Powers F, Stevenson KE, Jones M, Ng SY, Wu G, Jain S, Xu R, Amaka S, Trevisani C, Donaldson N, Hagner PR, de Leval L, Gaulard P, Iqbal J, Thakurta A, Fischer ES, Adelman K, Weinstock DM
Prediction and Validation of a Protein's Free Energy Surface Using Hydrogen Exchange and (Importantly) Its Denaturant Dependence.
1. J Chem Theory Comput - published December 2, 2021
2. Peng X, Baxa M, Faruk N, Sachleben JR, Pintscher S, Gagnon IA, Houliston S, Arrowsmith CH, Freed KF, Rocklin GJ, Sosnick TR
Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism.
1. Nature - published December 2, 2021
2. Wang RY, Noddings CM, Kirschke E, Myasnikov AG, Johnson JL, Agard DA
Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2.
1. Elife - published December 2, 2021
2. Feng J, Dong X, DeCosta A, Su Y, Angrisano F, Sala KA, Blagborough AM, Lu C, Springer TA
Multifaceted Regulation of Akt by Diverse C-Terminal Post-translational Modifications.
1. ACS Chem Biol - published December 2, 2021
2. Salguero AL, Chen M, Balana AT, Chu N, Jiang H, Palanski BA, Bae H, Wright KM, Nathan S, Zhu H, Gabelli SB, Pratt MR, Cole PA
Structure of Hsp90-p23-GR reveals the Hsp90 client-remodelling mechanism.
1. Nature - published December 2, 2021
2. Noddings CM, Wang RY, Johnson JL, Agard DA
The fluorescent aptamer Squash extensively repurposes the adenine riboswitch fold.
1. Nat Chem Biol - published December 2, 2021
2. Truong L, Kooshapur H, Dey SK, Li X, Tjandra N, Jaffrey SR, Ferré-D'Amaré AR
Structure and ion-release mechanism of P_IB-4-type ATPases.
1. Elife - published December 2, 2021
2. Grønberg C, Hu Q, Mahato DR, Longhin E, Salustros N, Duelli A, Lyu P, Bågenholm V, Eriksson J, Rao KU, Henderson DI, Meloni G, Andersson M, Croll T, Godaly G, Wang K, Gourdon P
Molecular determinants of phase separation for Drosophila DNA replication licensing factors.
1. Elife - published December 2, 2021
2. Parker MW, Kao JA, Huang A, Berger JM, Botchan MR
Inhibition of p53 sulfoconjugation prevents oxidative hepatotoxicity and acute liver failure.
1. Gastroenterology - published December 2, 2021
2. Xu P, Xi Y, Wang P, Luka Z, Xu M, Tung HC, Wang J, Ren S, Feng D, Gao B, Singhi AD, Monga SP, York JD, Ma X, Huang Z, Xie W
Structural and mechanistic insight into CRISPR-Cas9 inhibition by anti-CRISPR protein AcrIIC4_Hpa.
1. J Mol Biol - published December 2, 2021
2. Hwang S, Pan C, Garcia B, Davidson AR, Moraes TF, Maxwell KL
The conformational state of the BTK substrate PLCγ contributes to Ibrutinib resistance.
1. J Mol Biol - published December 2, 2021
2. Joseph RE, Lowe J, Bruce Fulton D, Engen JR, Wales TE, Andreotti AH
New insights into the molecular mechanisms of glutaminase C inhibitors in cancer cells using serial room temperature crystallography.
1. J Biol Chem - published December 2, 2021
2. Milano SK, Huang Q, Nguyen TT, Ramachandran S, Finke A, Kriksunov I, Schuller D, Szebenyi M, Arenholz E, McDermott LA, Sukumar N, Cerione RA, Katt WP
RNAs Containing Carbocyclic Ribonucleotides.
1. Org Lett - published December 2, 2021
2. Akabane-Nakata M, Chickering T, Harp JM, Schlegel MK, Matsuda S, Egli M, Manoharan M
Differential effects of modified batrachotoxins on voltage-gated sodium channel fast and slow inactivation.
1. Cell Chem Biol - published December 2, 2021
2. MacKenzie TMG, Abderemane-Ali F, Garrison CE, Minor DL Jr, Bois JD
Acid-Catalyzed Synthesis of Isatoic Anhydride-8-Secondary Amides Enables IASA Transformations for Medicinal Chemistry.
1. J Org Chem - published December 2, 2021
2. Gondi SR, Shaik A, Westover KD
Identification of Evolutionary Trajectories Associated with Antimicrobial Resistance Using Microfluidics.
1. ACS Infect Dis - published December 2, 2021
2. Seo S, Disney-McKeethen S, Prabhakar RG, Song X, Mehta HH, Shamoo Y
Symmetry Reduction in a Hyperpolarization-Activated Homotetrameric Ion Channel.
1. Biochemistry - published December 2, 2021
2. Dickinson MS, Pourmal S, Gupta M, Bi M, Stroud RM
Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216.
1. J Med Chem - published December 2, 2021
2. Teng M, Lu W, Donovan KA, Sun J, Krupnick NM, Nowak RP, Li YD, Sperling AS, Zhang T, Ebert BL, Fischer ES, Gray NS
GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity.
1. Cancer Cell - published December 2, 2021
2. Heitzeneder S, Bosse KR, Zhu Z, Zhelev D, Majzner RG, Radosevich MT, Dhingra S, Sotillo E, Buongervino S, Pascual-Pasto G, Garrigan E, Xu P, Huang J, Salzer B, Delaidelli A, Raman S, Cui H, Martinez B, Bornheimer SJ, Sahaf B, Alag A, Fetahu IS, Hasselblatt M, Parker KR, Anbunathan H, Hwang J, Huang M, Sakamoto K, Lacayo NJ, Klysz DD, Theruvath J, Vilches-Moure JG, Satpathy AT, Chang HY, Lehner M, Taschner-Mandl S, Julien JP, Sorensen PH, Dimitrov DS, Maris JM, Mackall CL
The ASCC2 CUE domain in the ALKBH3-ASCC DNA repair complex recognizes adjacent ubiquitins in K63-linked polyubiquitin.
1. J Biol Chem - published December 2, 2021
2. Lombardi PM, Haile S, Rusanov T, Rodell R, Anoh R, Baer JG, Burke KA, Gray LN, Hacker AR, Kebreau KR, Ngandu CK, Orland HA, Osei-Asante E, Schmelyun DP, Shorb DE, Syed SH, Veilleux JM, Majumdar A, Mosammaparast N, Wolberger C
It takes two to Tango: Two gates orchestrate the opening of human TRPM2.
1. Cell Calcium - published December 2, 2021
2. Rish AD, Shen Z, Fu TM
Minimal Pathway for the Regeneration of Redox Cofactors.
1. JACS Au - published December 2, 2021
2. Partipilo M, Ewins EJ, Frallicciardi J, Robinson T, Poolman B, Slotboom DJ
Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization.
1. Immunity - published December 2, 2021
2. Weber T, Potthoff J, Bizu S, Labuhn M, Dold L, Schoofs T, Horning M, Ercanoglu MS, Kreer C, Gieselmann L, Vanshylla K, Langhans B, Janicki H, Ströh LJ, Knops E, Nierhoff D, Spengler U, Kaiser R, Bjorkman PJ, Krey T, Bankwitz D, Pfeifer N, Pietschmann T, Flyak AI, Klein F
Preventing Pseudomonas aeruginosa Biofilms on Indwelling Catheters by Surface-Bound Enzymes.
1. ACS Appl Bio Mater - published December 2, 2021
2. Asker D, Awad TS, Raju D, Sanchez H, Lacdao I, Gilbert S, Sivarajah P, Andes DR, Sheppard DC, Howell PL, Hatton BD
Cleavage of talin by calpain promotes platelet-mediated fibrin clot contraction.
1. Blood Adv - published December 1, 2021
2. Fong KP, Molnar KS, Agard N, Litvinov RI, Kim OV, Wells JA, Weisel JW, DeGrado WF, Bennett JS
ATAD2 controls chromatin-bound HIRA turnover.
1. Life Sci Alliance - published December 1, 2021
2. Wang T, Perazza D, Boussouar F, Cattaneo M, Bougdour A, Chuffart F, Barral S, Vargas A, Liakopoulou A, Puthier D, Bargier L, Morozumi Y, Jamshidikia M, Garcia-Saez I, Petosa C, Rousseaux S, Verdel A, Khochbin S
Purification of full-length recombinant human huntingtin proteins with allelic series of polyglutamine lengths.
1. STAR Protoc - published December 1, 2021
2. Kim H, Hyun KG, Lloret A, Seong IS, Song JJ
There is a lock for every key.
1. Nat Chem Biol - published December 1, 2021
2. Yu W, Baskin JM
Metabolites with SARS-CoV-2 Inhibitory Activity Identified from Human Microbiome Commensals.
1. mSphere - published December 1, 2021
2. Piscotta FJ, Hoffmann HH, Choi YJ, Small GI, Ashbrook AW, Koirala B, Campbell EA, Darst SA, Rice CM, Brady SF
Structure of CRL2Lrr1, the E3 ubiquitin ligase that promotes DNA replication termination in vertebrates.
1. Nucleic Acids Res - published December 1, 2021
2. Zhou H, Zaher MS, Walter JC, Brown A
Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut.
1. Nat Commun - published December 1, 2021
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NAD+-consuming enzymes in immune defense against viral infection.
1. Biochem J - published December 1, 2021
2. Shang J, Smith MR, Anmangandla A, Lin H
Structures of neurokinin 1 receptor in complex with G_q and G_s proteins reveal substance P binding mode and unique activation features.
1. Sci Adv - published December 1, 2021
2. Thom C, Ehrenmann J, Vacca S, Waltenspühl Y, Schöppe J, Medalia O, Plückthun A
Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function.
1. iScience - published December 1, 2021
2. Rosier K, McDevitt MT, Smet J, Floyd BJ, Verschoore M, Marcaida MJ, Bingman CA, Lemmens I, Dal Peraro M, Tavernier J, Cravatt BF, Gounko NV, Vints K, Monnens Y, Bhalla K, Aerts L, Rashan EH, Vanlander AV, Van Coster R, Régal L, Pagliarini DJ, Creemers JWM
Subcortical-Cortical Functional Connectivity as a Potential Biomarker for Identifying Patients with Functional Dyspepsia.
1. Cereb Cortex - published December 1, 2021
2. Yin T, Sun R, He Z, Chen Y, Yin S, Liu X, Lu J, Ma P, Zhang T, Huang L, Qu Y, Suo X, Lei D, Gong Q, Liang F, Li S, Zeng F
Structural insights into metazoan pretargeting GET complexes.
1. Nat Struct Mol Biol - published December 1, 2021
2. Keszei AFA, Yip MCJ, Hsieh TC, Shao S
Structural basis of DNA methylation-dependent site selectivity of the Epstein-Barr virus lytic switch protein ZEBRA/Zta/BZLF1.
1. Nucleic Acids Res - published December 1, 2021
2. Bernaudat F, Gustems M, Günther J, Oliva MF, Buschle A, Göbel C, Pagniez P, Lupo J, Signor L, Müller CW, Morand P, Sattler M, Hammerschmidt W, Petosa C
Synthesis and Application of Constrained Amidoboronic Acids Using Amphoteric Boron-Containing Building Blocks.
1. J Org Chem - published December 1, 2021
2. Soor HS, Diaz DB, Tsui KY, Calvopiña K, Bielinski M, Tantillo DJ, Schofield CJ, Yudin AK
A model for the signal initiation complex between Arrestin-3 and the Src family kinase Fgr.
1. J Mol Biol - published December 1, 2021
2. Perez I, Berndt S, Agarwal R, Castro MA, Vishnivetskiy SA, Smith JC, Sanders CR, Gurevich VV, Iverson TM
Antibody screening at reduced pH enables preferential selection of potently neutralizing antibodies targeting SARS-CoV-2.
1. AIChE J - published December 1, 2021
2. Madan B, Reddem ER, Wang P, Casner RG, Nair MS, Huang Y, Fahad AS, de Souza MO, Banach BB, López Acevedo SN, Pan X, Nimrania R, Teng IT, Bahna F, Zhou T, Zhang B, Yin MT, Ho DD, Kwong PD, Shapiro L, DeKosky BJ
Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ.
1. Elife - published December 1, 2021
2. Mensa B, Polizzi NF, Molnar KS, Natale AM, Lemmin T, DeGrado WF
SARS-CoV-2 ferritin nanoparticle vaccine induces robust innate immune activity driving polyfunctional spike-specific T cell responses.
1. NPJ Vaccines - published December 1, 2021
2. Carmen JM, Shrivastava S, Lu Z, Anderson A, Morrison EB, Sankhala RS, Chen WH, Chang WC, Bolton JS, Matyas GR, Michael NL, Joyce MG, Modjarrad K, Currier JR, Bergmann-Leitner E, Malloy AMW, Rao M
Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.
1. Sci Adv - published December 1, 2021
2. Shubina-Oleinik O, Nist-Lund C, French C, Rockowitz S, Shearer AE, Holt JR
The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection.
1. PLoS Pathog - published December 1, 2021
2. Bieri M, Hendrickx R, Bauer M, Yu B, Jetzer T, Dreier B, Mittl PRE, Sobek J, Plückthun A, Greber UF, Hemmi S
InDeep: 3D fully convolutional neural networks to assist in silico drug design on protein-protein interactions.
1. Bioinformatics - published December 1, 2021
2. Mallet V, Checa Ruano L, Moine Franel A, Nilges M, Druart K, Bouvier G, Sperandio O
Nanoparticles and photochemistry for native-like transmembrane protein footprinting.
1. Nat Commun - published December 1, 2021
2. Sun J, Liu XR, Li S, He P, Li W, Gross ML
Effects of chameleon dispense-to-plunge speed on particle concentration, complex formation, and final resolution: A case study using the Neisseria gonorrhoeae ribonucleotide reductase inactive complex.
1. J Struct Biol - published December 1, 2021
2. Levitz TS, Brignole EJ, Fong I, Darrow MC, Drennan CL
A Chemoproteomics Approach to Profile Phospholipase D-Derived Phosphatidyl Alcohol Interactions.
1. ACS Chem Biol - published December 1, 2021
2. Yu W, Lin Z, Woo CM, Baskin JM
How to train your antibody to fight malaria.
1. Immunity - published December 1, 2021
2. Stalls V, Acharya P
Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α.
1. Nat Commun - published December 1, 2021
2. Le Thomas A, Ferri E, Marsters S, Harnoss JM, Lawrence DA, Zuazo-Gaztelu I, Modrusan Z, Chan S, Solon M, Chalouni C, Li W, Koeppen H, Rudolph J, Wang W, Wu TD, Walter P, Ashkenazi A
ER proteins decipher the tubulin code to regulate organelle distribution.
1. Nature - published December 1, 2021
2. Zheng P, Obara CJ, Szczesna E, Nixon-Abell J, Mahalingan KK, Roll-Mecak A, Lippincott-Schwartz J, Blackstone C
Mapping of the fibrinogen-binding site on the staphylocoagulase C-terminal repeat region.
1. J Biol Chem - published December 1, 2021
2. Maddur AA, Voehler M, Panizzi P, Meiler J, Bock PE, Verhamme IM
Critical review of nucleic acid nanotechnology to identify gaps and inform a strategy for accelerated clinical translation.
1. Adv Drug Deliv Rev - published December 1, 2021
2. Afonin KA, Dobrovolskaia MA, Ke W, Grodzinski P, Bathe M
A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates.
1. Sci Transl Med - published December 1, 2021
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Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network.
1. Sci Adv - published December 1, 2021
2. Lopez A, Dahiya V, Delhommel F, Freiburger L, Stehle R, Asami S, Rutz D, Blair L, Buchner J, Sattler M
The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer.
1. Mol Cell - published December 1, 2021
2. Rudolph J, Muthurajan UM, Palacio M, Mahadevan J, Roberts G, Erbse AH, Dyer PN, Luger K
Distinct sequence features underlie microdeletions and gross deletions in the human genome.
1. Hum Mutat - published December 1, 2021
2. Qi M, Stenson PD, Ball EV, Tainer JA, Bacolla A, Kehrer-Sawatzki H, Cooper DN, Zhao H
Analysing an allelic series of rare missense variants of CACNA1I in a Swedish schizophrenia cohort.
1. Brain - published December 1, 2021
2. Baez-Nieto D, Allen A, Akers-Campbell S, Yang L, Budnik N, Pupo A, Shin YC, Genovese G, Liao M, Pérez-Palma E, Heyne H, Lal D, Lipscombe D, Pan JQ
Protein engineering strategies for rational immunogen design.
1. NPJ Vaccines - published December 1, 2021
2. Caradonna TM, Schmidt AG
A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis.
1. Nat Commun - published December 1, 2021
2. Yao F, Deng Y, Zhao Y, Mei Y, Zhang Y, Liu X, Martinez C, Su X, Rosato RR, Teng H, Hang Q, Yap S, Chen D, Wang Y, Chen MM, Zhang M, Liang H, Xie D, Chen X, Zhu H, Chang JC, You MJ, Sun Y, Gan B, Ma L
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant.
1. medRxiv - published December 1, 2021
2. Garcia-Beltran WF, St Denis KJ, Hoelzemer A, Lam EC, Nitido AD, Sheehan ML, Berrios C, Ofoman O, Chang CC, Hauser BM, Feldman J, Gregory DJ, Poznansky MC, Schmidt AG, Iafrate AJ, Naranbhai V, Balazs AB
Potent macrocycle inhibitors of the human SAGA deubiquitinating module.
1. Cell Chem Biol - published December 1, 2021
2. Morgan M, Ikenoue T, Suga H, Wolberger C
Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase.
1. Mol Cell - published December 1, 2021
2. Ji Z, Li H, Peterle D, Paulo JA, Ficarro SB, Wales TE, Marto JA, Gygi SP, Engen JR, Rapoport TA
Ferroptosis in Non-Small Cell Lung Cancer: Progression and Therapeutic Potential on It.
1. Int J Mol Sci - published December 1, 2021
2. Zou J, Wang L, Tang H, Liu X, Peng F, Peng C
Structural biology of cation channels important for lysosomal calcium release.
1. Cell Calcium - published December 1, 2021
2. Gan N, Jiang Y
Binding Affinity Determines Substrate Specificity and Enables Discovery of Substrates for N-Myristoyltransferases.
1. ACS Catal - published December 1, 2021
2. Su D, Kosciuk T, Yang M, Price IR, Lin H
Inositol Phosphates and Retroviral Assembly: A Cellular Perspective.
1. Viruses - published December 1, 2021
2. Ricaña CL, Dick RA
Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern.
1. Cell Rep - published December 1, 2021
2. Li W, Chen Y, Prévost J, Ullah I, Lu M, Gong SY, Tauzin A, Gasser R, Vézina D, Anand SP, Goyette G, Chaterjee D, Ding S, Tolbert WD, Grunst MW, Bo Y, Zhang S, Richard J, Zhou F, Huang RK, Esser L, Zeher A, Côté M, Kumar P, Sodroski J, Xia D, Uchil PD, Pazgier M, Finzi A, Mothes W
High-fidelity biosensing of dNTPs and nucleic acids by controllable subnanometer channel PaMscS.
1. Biosens Bioelectron - published December 1, 2021
2. Zhao C, Li K, Mou X, Zhu Y, Chen C, Zhang M, Wang Y, Zhou K, Sheng Y, Liu H, Bai Y, Li X, Zhou C, Deng D, Wu J, Wu HC, Bao R, Geng J