Member Publications

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121 Member Publications for January 2022

Angiotensin-Converting Enzyme Genotype-Specific Immune Response Contributes to the Susceptibility of COVID-19: A Nested Case-Control Study.
1. Front Pharmacol - published January 31, 2022
2. Gong P, Mei F, Li R, Wang Y, Li W, Pan K, Xu J, Liu C, Li H, Cai K, Shi W
Corrigendum: Molecular Dissection of the Primase and Polymerase Activities of Deep-Sea Phage NrS-1 Primase-Polymerase.
1. Front Microbiol - published January 28, 2022
2. Huang F, Lu X, Yu C, Sliz P, Wang L, Zhu B
Structural Biology Illuminates Molecular Determinants of Broad Ebolavirus Neutralization by Human Antibodies for Pan-Ebolavirus Therapeutic Development.
1. Front Immunol - published January 27, 2022
2. Murin CD, Gilchuk P, Crowe JE Jr, Ward AB
Within and Beyond the Nucleotide Addition Cycle of Viral RNA-dependent RNA Polymerases.
1. Front Mol Biosci - published January 27, 2022
2. Gong P
Druggable Lipid Binding Sites in Pentameric Ligand-Gated Ion Channels and Transient Receptor Potential Channels.
1. Front Physiol - published January 24, 2022
2. Cheng WWL, Arcario MJ, Petroff JT 2nd
Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death.
1. Comput Struct Biotechnol J - published January 24, 2022
2. Margreiter MA, Witzenberger M, Wasser Y, Davydova E, Janowski R, Metz J, Habib P, Sahnoun SEM, Sobisch C, Poma B, Palomino-Hernandez O, Wagner M, Carell T, Jon Shah N, Schulz JB, Niessing D, Voigt A, Rossetti G
The Mysterious Multitude: Structural Perspective on the Accessory Subunits of Respiratory Complex I.
1. Front Mol Biosci - published January 20, 2022
2. Padavannil A, Ayala-Hernandez MG, Castellanos-Silva EA, Letts JA
Structural Basis of Antibody Conformation and Stability Modulation by Framework Somatic Hypermutation.
1. Front Immunol - published January 20, 2022
2. Sheng Z, Bimela JS, Katsamba PS, Patel SD, Guo Y, Zhao H, Guo Y, Kwong PD, Shapiro L
Absence of Cardiolipin From the Outer Leaflet of a Mitochondrial Inner Membrane Mimic Restricts Opa1-Mediated Fusion.
1. Front Mol Biosci - published January 10, 2022
2. Ge Y, Boopathy S, Nguyen TH, Lugo CM, Chao LH
Polyclonal Broadly Neutralizing Antibody Activity Characterized by CD4 Binding Site and V3-Glycan Antibodies in a Subset of HIV-1 Virus Controllers.
1. Front Immunol - published January 10, 2022
2. Nyanhete TE, Edwards RJ, LaBranche CC, Mansouri K, Eaton A, Dennison SM, Saunders KO, Goodman D, Janowska K, Spreng RL, Zhang L, Mudrak SV, Hope TJ, Hora B, Bradley T, Georgiev IS, Montefiori DC, Acharya P, Tomaras GD
NADH/NAD⁺ binding and linked tetrameric assembly of the oncogenic transcription factors CtBP1 and CtBP2.
1. FEBS Lett - published January 8, 2022
2. Erlandsen H, Jecrois AM, Nichols JC, Cole JL, Royer WE Jr
Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report.
1. Ann N Y Acad Sci - published January 8, 2022
2. Cable J, Weber-Ban E, Clausen T, Walters KJ, Sharon M, Finley DJ, Gu Y, Hanna J, Feng Y, Martens S, Simonsen A, Hansen M, Zhang H, Goodwin JM, Reggio A, Chang C, Ge L, Schulman BA, Deshaies RJ, Dikic I, Harper JW, Wertz IE, Thomä NH, Słabicki M, Frydman J, Jakob U, David DC, Bennett EJ, Bertozzi CR, Sardana R, Eapen VV, Carra S
A Structural Perspective on the RNA Editing of Plant Respiratory Complexes.
1. Int J Mol Sci - published January 8, 2022
2. Maldonado M, Abe KM, Letts JA
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex.
1. Sci Adv - published January 7, 2022
2. Hurdiss DL, El Kazzi P, Bauer L, Papageorgiou N, Ferron FP, Donselaar T, van Vliet ALW, Shamorkina TM, Snijder J, Canard B, Decroly E, Brancale A, Zeev-Ben-Mordehai T, Förster F, van Kuppeveld FJM, Coutard B
B cell overexpression of FCRL5 and PD-1 is associated with low antibody titers in HCV infection.
1. PLoS Pathog - published January 6, 2022
2. Ogega CO, Skinner NE, Flyak AI, Clark KE, Board NL, Bjorkman PJ, Crowe JE Jr, Cox AL, Ray SC, Bailey JR
Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3-PEX19 Interaction.
1. Front Cell Dev Biol - published January 6, 2022
2. Li M, Gaussmann S, Tippler B, Ott J, Popowicz GM, Schliebs W, Sattler M, Erdmann R, Kalel VC
Mechanism of CFTR correction by type I folding correctors.
1. Cell - published January 6, 2022
2. Fiedorczuk K, Chen J
Author Correction: Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex at 3.6 Å resolution.
1. Nature - published January 6, 2022
2. Sugita Y, Matsunami H, Kawaoka Y, Noda T, Wolf M
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant.
1. Cell - published January 6, 2022
2. Garcia-Beltran WF, St Denis KJ, Hoelzemer A, Lam EC, Nitido AD, Sheehan ML, Berrios C, Ofoman O, Chang CC, Hauser BM, Feldman J, Roederer AL, Gregory DJ, Poznansky MC, Schmidt AG, Iafrate AJ, Naranbhai V, Balazs AB
High-resolution structures of mitochondrial glutaminase C tetramers indicate conformational changes upon phosphate binding.
1. J Biol Chem - published January 6, 2022
2. Nguyen TT, Ramachandran S, Hill MJ, Cerione RA
Effect of Cooling Rate on the Microstructure Evolution and Mechanical Properties of Iron-Rich Al-Si Alloy.
1. Materials (Basel) - published January 6, 2022
2. Shen X, Liu S, Wang X, Cui C, Gong P, Zhao L, Han X, Li Z
Defluorination Capability of l-2-Haloacid Dehalogenases in the HAD-Like Hydrolase Superfamily Correlates with Active Site Compactness.
1. Chembiochem - published January 5, 2022
2. Chan PWY, Chakrabarti N, Ing C, Halgas O, To TKW, Wälti M, Petit AP, Tran C, Savchenko A, Yakunin AF, Edwards EA, Pomès R, Pai EF
Multiscale Simulation of an Influenza A M2 Channel Mutant Reveals Key Features of Its Markedly Different Proton Transport Behavior.
1. J Am Chem Soc - published January 5, 2022
2. Watkins LC, DeGrado WF, Voth GA
Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity.
1. PLoS One - published January 5, 2022
2. Roggero CM, Esser V, Duan L, Rice AM, Ma S, Raj GV, Rosen MK, Liu ZP, Rizo J
Engineering a Dynamic Controllable Infectivity Switch in Bacteriophage T7.
1. ACS Synth Biol - published January 5, 2022
2. Chitboonthavisuk C, Luo CH, Huss P, Fernholz M, Raman S
Exon-independent recruitment of SRSF1 is mediated by U1 snRNP stem-loop 3.
1. EMBO J - published January 4, 2022
2. Jobbins AM, Campagne S, Weinmeister R, Lucas CM, Gosliga AR, Clery A, Chen L, Eperon LP, Hodson MJ, Hudson AJ, Allain FHT, Eperon IC
Lipid bilayer induces contraction of the denatured state ensemble of a helical-bundle membrane protein.
1. Proc Natl Acad Sci U S A - published January 4, 2022
2. Gaffney KA, Guo R, Bridges MD, Muhammednazaar S, Chen D, Kim M, Yang Z, Schilmiller AL, Faruk NF, Peng X, Jones AD, Kim KH, Sun L, Hubbell WL, Sosnick TR, Hong H
Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands.
1. Elife - published January 4, 2022
2. Nichols AL, Blumenfeld Z, Fan C, Luebbert L, Blom AE, Cohen BN, Marvin JS, Borden PM, Kim CH, Muthusamy AK, Shivange AV, Knox HJ, Campello HR, Wang JH, Dougherty DA, Looger LL, Gallagher T, Rees DC, Lester HA
Author Correction: Visualizing group II intron dynamics between the first and second steps of splicing.
1. Nat Commun - published January 4, 2022
2. Manigrasso J, Chillón I, Genna V, Vidossich P, Somarowthu S, Pyle AM, De Vivo M, Marcia M
Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins.
1. Proc Natl Acad Sci U S A - published January 4, 2022
2. Ingólfsson HI, Neale C, Carpenter TS, Shrestha R, López CA, Tran TH, Oppelstrup T, Bhatia H, Stanton LG, Zhang X, Sundram S, Di Natale F, Agarwal A, Dharuman G, Kokkila Schumacher SIL, Turbyville T, Gulten G, Van QN, Goswami D, Jean-Francois F, Agamasu C, Chen, Hettige JJ, Travers T, Sarkar S, Surh MP, Yang Y, Moody A, Liu S, Van Essen BC, Voter AF, Ramanathan A, Hengartner NW, Simanshu DK, Stephen AG, Bremer PT, Gnanakaran S, Glosli JN, Lightstone FC, McCormick F, Nissley DV, Streitz FH
Independent Drug Action in Combination Therapy: Implications for Precision Oncology.
1. Cancer Discov - published January 4, 2022
2. Plana D, Palmer AC, Sorger PK
A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice.
1. J Exp Med - published January 3, 2022
2. Mao T, Israelow B, Lucas C, Vogels CBF, Gomez-Calvo ML, Fedorova O, Breban MI, Menasche BL, Dong H, Linehan M, Yale SARS-CoV-2 Genome Surveillance Initiative., Wilen CB, Landry ML, Grubaugh ND, Pyle AM, Iwasaki A
Advances toward structure-based drug discovery for inflammasome targets.
1. J Exp Med - published January 3, 2022
2. Wang L, Crackower MA, Wu H
Molecular Dissection of the Primase and Polymerase Activities of Deep-Sea Phage NrS-1 Primase-Polymerase.
1. Front Microbiol - published January 3, 2022
2. Huang F, Lu X, Yu C, Sliz P, Wang L, Zhu B
Protection of the prodomain α1-helix correlates with latency in the transforming growth factor-β family.
1. J Mol Biol - published January 3, 2022
2. Le VQ, Iacob RE, Zhao B, Su Y, Tian Y, Toohey C, Engen JR, Springer TA
The Pseudomonas aeruginosa homeostasis enzyme AlgL clears the periplasmic space of accumulated alginate during polymer biosynthesis.
1. J Biol Chem - published January 3, 2022
2. Gheorghita AA, Wolfram F, Whitfield GB, Jacobs HM, Pfoh R, Wong SSY, Guitor AK, Goodyear MC, Berezuk AM, Khursigara CM, Parsek MR, Howell PL
The global case fatality rate of coronavirus disease 2019 by continents and national income: A meta-analysis.
1. J Med Virol - published January 3, 2022
2. Abou Ghayda R, Lee KH, Han YJ, Ryu S, Hong SH, Yoon S, Jeong GH, Yang JW, Lee HJ, Lee J, Lee JY, Effenberger M, Eisenhut M, Kronbichler A, Solmi M, Li H, Jacob L, Koyanagi A, Radua J, Park MB, Aghayeva S, Ahmed MLCB, Al Serouri A, Al-Shamsi HO, Amir-Behghadami M, Baatarkhuu O, Bashour H, Bondarenko A, Camacho-Ortiz A, Castro F, Cox H, Davtyan H, Douglas K, Dragioti E, Ebrahim S, Ferioli M, Harapan H, Mallah SI, Ikram A, Inoue S, Jankovic S, Jayarajah U, Jesenak M, Kakodkar P, Kebede Y, Kifle M, Koh D, Males VK, Kotfis K, Lakoh S, Ling L, Llibre-Guerra J, Machida M, Makurumidze R, Mamun M, Masic I, Van Minh H, Moiseev S, Nadasdy T, Nahshon C, Ñamendys-Silva SA, Yongsi BN, Nielsen HB, Nodjikouambaye ZA, Ohnmar O, Oksanen A, Owopetu O, Parperis K, Perez GE, Pongpirul K, Rademaker M, Rosa S, Sah R, Sallam D, Schober P, Singhal T, Tafaj S, Torres I, Torres-Roman JS, Tsartsalis D, Tsolmon J, Tuychiev L, Vukcevic B, Wanghi G, Wollina U, Xu RH, Yang L, Zaidi Z, Smith L, Shin JI
Proteomics in uveal melanoma.
1. Curr Opin Ophthalmol - published January 3, 2022
2. Heiferman MJ, Mahajan VB, Mruthyunjaya P
TdfH selectively binds metal-loaded tetrameric calprotectin for zinc import.
1. Commun Biol - published January 3, 2022
2. Bera AK, Wu R, Harrison S, Cornelissen CN, Chazin WJ, Noinaj N
Well Put Together-A Guide to Accessorizing with the Herpesvirus gH/gL Complexes.
1. Viruses - published January 3, 2022
2. Gonzalez-Del Pino GL, Heldwein EE
Selective binding of small molecules to Vibrio cholerae DsbA offers a starting point for the design of novel antibacterials.
1. ChemMedChem - published January 2, 2022
2. Wang G, Mohanty B, Williams ML, Doak BC, Dhouib R, Totsika M, McMahon R, Sharma G, Zheng D, Bentley MR, Chin YK, Horne J, Chalmers DK, Heras B, Scanlon MJ
Sequence and functional characterization of a public HIV-specific antibody clonotype.
1. iScience - published January 2, 2022
2. Murji AA, Raju N, Qin JS, Kaldine H, Janowska K, Fechter EF, Mapengo R, Scheepers C, Setliff I, Acharya P, Morris L, Georgiev IS
From structure to sequence: Antibody discovery using cryoEM.
1. Sci Adv - published January 2, 2022
2. Antanasijevic A, Bowman CA, Kirchdoerfer RN, Cottrell CA, Ozorowski G, Upadhyay AA, Cirelli KM, Carnathan DG, Enemuo CA, Sewall LM, Nogal B, Zhao F, Groschel B, Schief WR, Sok D, Silvestri G, Crotty S, Bosinger SE, Ward AB
Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation.
1. Elife - published January 2, 2022
2. Case LB, De Pasquale M, Henry L, Rosen MK
YTHDC2 control of gametogenesis requires helicase activity but not m⁶A binding.
1. Genes Dev - published January 2, 2022
2. Saito Y, Hawley BR, Puno MR, Sarathy SN, Lima CD, Jaffrey SR, Darnell RB, Keeney S, Jain D
Karyopherin-mediated nucleocytoplasmic transport.
1. Nat Rev Mol Cell Biol - published January 2, 2022
2. Wing CE, Fung HYJ, Chook YM
Structural basis for substrate binding and catalysis by a self-alkylating ribozyme.
1. Nat Chem Biol - published January 2, 2022
2. Krochmal D, Shao Y, Li NS, DasGupta S, Shelke SA, Koirala D, Piccirilli JA
Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins.
1. Sci Adv - published January 2, 2022
2. Tsutsumi N, Maeda S, Qu Q, Vögele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC
De novo variants in AGO1 recapitulate a heterogeneous neurodevelopmental disorder phenotype.
1. Clin Genet - published January 2, 2022
2. Niu Y, Qian Q, Li J, Gong P, Jiao X, Mao X, Xiao B, Long L, Yang Z
Engineering pan-HIV-1 neutralization potency through multispecific antibody avidity.
1. Proc Natl Acad Sci U S A - published January 2, 2022
2. Rujas E, Cui H, Burnie J, Aschner CB, Zhao T, Insausti S, Muthuraman K, Semesi A, Ophel J, Nieva JL, Seaman MS, Guzzo C, Treanor B, Julien JP
Clonally Expanded B Cells in Multiple Sclerosis Bind EBV EBNA1 and GlialCAM.
1. Nature - published January 2, 2022
2. Lanz TV, Brewer RC, Ho PP, Moon JS, Jude KM, Fernandez D, Fernandes RA, Gomez AM, Nadj GS, Bartley CM, Schubert RD, Hawes IA, Vazquez SE, Iyer M, Zuchero JB, Teegen B, Dunn JE, Lock CB, Kipp LB, Cotham VC, Ueberheide BM, Aftab BT, Anderson MS, DeRisi JL, Wilson MR, Bashford-Rogers RJM, Platten M, Garcia KC, Steinman L, Robinson WH
Psychosocial Stressors and Coping Strategies Among African Americans During Early Stages of the COVID-19 Pandemic: a Qualitative Study.
1. J Racial Ethn Health Disparities - published January 2, 2022
2. Gillyard T, Davis J, Parham I, Moss J, Barre I, Alexander L, Cunningham-Erves J
Neutrophil-associated responses to Vibrio cholerae infection in a natural host model.
1. Infect Immun - published January 2, 2022
2. Farr D, Nag D, Chazin WJ, Harrison S, Thummel R, Luo X, Raychaudhuri S, Withey JH
How the α-helix got its name.
1. Nat Rev Mol Cell Biol - published January 2, 2022
2. Egli M, Zhang S
The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in non-human primates and has an extended half-life in humans.
1. Sci Transl Med - published January 2, 2022
2. Loo YM, McTamney PM, Arends RH, Abram ME, Aksyuk AA, Diallo S, Flores DJ, Kelly EJ, Ren K, Roque R, Rosenthal K, Streicher K, Tuffy KM, Bond NJ, Cornwell O, Bouquet J, Cheng LI, Dunyak J, Huang Y, Rosenbaum AI, Reddy VP, Andersen H, Carnahan RH, Crowe JE Jr, Kuehne AI, Herbert AS, Dye JM, Bright H, Kallewaard NL, Pangalos MN, Esser MT
Mechanism of action of nucleotide excision repair machinery.
1. Biochem Soc Trans - published January 2, 2022
2. D'Souza A, Blee AM, Chazin WJ
Structure of the human ATM kinase and mechanism of Nbs1 binding.
1. Elife - published January 2, 2022
2. Warren C, Pavletich NP
Reconstitution of purified membrane protein dimers in lipid nanodiscs with defined stoichiometry and orientation using a split GFP tether.
1. J Biol Chem - published January 2, 2022
2. Bruguera ES, Mahoney JP, Weis WI
Structures of the peptidase-containing ABC transporter PCAT1 under equilibrium and nonequilibrium conditions.
1. Proc Natl Acad Sci U S A - published January 2, 2022
2. Kieuvongngam V, Chen J
Functional Irreplaceability of Escherichia coli and Shewanella oneidensis OxyRs Is Critically Determined by Intrinsic Differences in Oligomerization.
1. mBio - published January 2, 2022
2. Sun W, Fan Y, Wan F, Tao YJ, Gao H
Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter.
1. Sci Adv - published January 2, 2022
2. Chaptal V, Zampieri V, Wiseman B, Orelle C, Martin J, Nguyen KA, Gobet A, Di Cesare M, Magnard S, Javed W, Eid J, Kilburg A, Peuchmaur M, Marcoux J, Monticelli L, Hogbom M, Schoehn G, Jault JM, Boumendjel A, Falson P
Brilacidin, a COVID-19 Drug Candidate, demonstrates broad-spectrum antiviral activity against human coronaviruses OC43, 229E and NL63 through targeting both the virus and the host cell.
1. J Med Virol - published January 2, 2022
2. Hu Y, Jo H, DeGrado WF, Wang J
Regulation of the BCR signalosome by the class II peptide editor, H2-M, affects the development and repertoire of innate-like B cells.
1. Cell Rep - published January 2, 2022
2. Ghosh D, Pham TD, Nanaware PP, Sengupta D, Adler LN, Li CG, He X, O'Mara ME, Kantor AB, Nguyen KD, Yang Y, Eisenlohr LC, Jensen PE, Herzenberg LA, Stern LJ, Boyd SD, Ghosn EEB, Mellins ED
Ion currents through Kir potassium channels are gated by anionic lipids.
1. Nat Commun - published January 2, 2022
2. Jin R, He S, Black KA, Clarke OB, Wu D, Bolla JR, Johnson P, Periasamy A, Wardak A, Czabotar P, Colman PM, Robinson CV, Laver D, Smith BJ, Gulbis JM
Persistent bacteremia and psoas abscess caused by a lethal toxin-deficient Paeniclostridiumsordellii.
1. Anaerobe - published January 2, 2022
2. Varley CD, Rogers LM, Dixon BR, Bernard SC, Lacy DB, Sulpizio E, Aronoff DM, Townes JM
The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites.
1. Nat Microbiol - published January 2, 2022
2. Campelo Morillo RA, Tong X, Xie W, Abel S, Orchard LM, Daher W, Patel DJ, Llinás M, Le Roch KG, Kafsack BFC
Modular peptide binders - development of a predictive technology as alternative for reagent antibodies.
1. Biol Chem - published January 2, 2022
2. Gisdon FJ, Kynast JP, Ayyildiz M, Hine AV, Plückthun A, Höcker B
Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor.
1. Sci Adv - published January 2, 2022
2. Welcker M, Wang B, Rusnac DV, Hussaini Y, Swanger J, Zheng N, Clurman BE
Structural basis for dysregulation of aminolevulinic acid synthase in human disease.
1. J Biol Chem - published January 2, 2022
2. Taylor JL, Brown BL
Rapid identification of neutralizing antibodies against SARS-CoV-2 variants by mRNA display.
1. Cell Rep - published January 2, 2022
2. Tanaka S, Olson CA, Barnes CO, Higashide W, Gonzalez M, Taft J, Richardson A, Martin-Fernandez M, Bogunovic D, Gnanapragasam PNP, Bjorkman PJ, Spilman P, Niazi K, Rabizadeh S, Soon-Shiong P
High-performance microbial opsins for spatially and temporally precise perturbations of large neuronal networks.
1. Neuron - published January 2, 2022
2. Sridharan S, Gajowa MA, Ogando MB, Jagadisan UK, Abdeladim L, Sadahiro M, Bounds HA, Hendricks WD, Turney TS, Tayler I, Gopakumar K, Oldenburg IA, Brohawn SG, Adesnik H
Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission.
1. Cell Host Microbe - published January 2, 2022
2. Escalera A, Gonzalez-Reiche AS, Aslam S, Mena I, Laporte M, Pearl RL, Fossati A, Rathnasinghe R, Alshammary H, van de Guchte A, Farrugia K, Qin Y, Bouhaddou M, Kehrer T, Zuliani-Alvarez L, Meekins DA, Balaraman V, McDowell C, Richt JA, Bajic G, Sordillo EM, Dejosez M, Zwaka TP, Krogan NJ, Simon V, Albrecht RA, van Bakel H, García-Sastre A, Aydillo T
DNA Polymerase-Parental DNA Interaction Is Essential for Helicase-Polymerase Coupling during Bacteriophage T7 DNA Replication.
1. Int J Mol Sci - published January 2, 2022
2. Lo CY, Gao Y
Midline epigastric scars can be associated with higher umbilical complications following DIEP flap harvest.
1. J Plast Reconstr Aesthet Surg - published January 2, 2022
2. Yang JH, Colakoglu S, Mureau MAM, Siddikoglu D, Johnson AC, Cohen JB, Lee BT, Chong TW, Mathes DW, Kaoutzanis C
RNA in biological condensates.
1. RNA - published January 1, 2022
2. Cech TR
Crystal structures of FolM alternative dihydrofolate reductase 1 from Brucella suis and Brucella canis.
1. Acta Crystallogr F Struct Biol Commun - published January 1, 2022
2. Porter I, Neal T, Walker Z, Hayes D, Fowler K, Billups N, Rhoades A, Smith C, Smith K, Staker BL, Dranow DM, Mayclin SJ, Subramanian S, Edwards TE, Myler PJ, Asojo OA
Crystal structure of a putative short-chain dehydrogenase/reductase from Paraburkholderia xenovorans.
1. Acta Crystallogr F Struct Biol Commun - published January 1, 2022
2. Davidson J, Nicholas K, Young J, Conrady DG, Mayclin S, Subramanian S, Staker BL, Myler PJ, Asojo OA
The crystal structure of DynF from the dynemicin-biosynthesis pathway of Micromonospora chersina.
1. Acta Crystallogr F Struct Biol Commun - published January 1, 2022
2. Kosgei AJ, Miller MD, Bhardwaj M, Xu W, Thorson JS, Van Lanen SG, Phillips GN Jr
Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules.
1. Proc Natl Acad Sci U S A - published January 1, 2022
2. LaFrance BJ, Roostalu J, Henkin G, Greber BJ, Zhang R, Normanno D, McCollum CO, Surrey T, Nogales E
Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family.
1. Elife - published January 1, 2022
2. Ramanadane K, Straub MS, Dutzler R, Manatschal C
Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease.
1. Nat Commun - published January 1, 2022
2. Yang Y, Tapias V, Acosta D, Xu H, Chen H, Bhawal R, Anderson ET, Ivanova E, Lin H, Sagdullaev BT, Chen J, Klein WL, Viola KL, Gandy S, Haroutunian V, Beal MF, Eliezer D, Zhang S, Gibson GE
Defensin-lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics.
1. Biochem Soc Trans - published January 1, 2022
2. Hein MJA, Kvansakul M, Lay FT, Phan TK, Hulett MD
Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance.
1. Elife - published January 1, 2022
2. Tsai K, Stojković V, Noda-Garcia L, Young ID, Myasnikov AG, Kleinman J, Palla A, Floor SN, Frost A, Fraser JS, Tawfik DS, Fujimori DG
Conceptual Exchanges for Understanding Free-Living and Host-Associated Microbiomes.
1. mSystems - published January 1, 2022
2. Pfister CA, Light SH, Bohannan B, Schmidt T, Martiny A, Hynson NA, Devkota S, David L, Whiteson K
Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival.
1. Blood Cancer Discov - published January 1, 2022
2. Li M, Teater MR, Hong JY, Park NR, Duy C, Shen H, Wang L, Chen Z, Cerchietti L, Davidson SM, Lin H, Melnick AM
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses.
1. Cell Chem Biol - published January 1, 2022
2. Napolitano V, Dabrowska A, Schorpp K, Mourão A, Barreto-Duran E, Benedyk M, Botwina P, Brandner S, Bostock M, Chykunova Y, Czarna A, Dubin G, Fröhlich T, Hölscher M, Jedrysik M, Matsuda A, Owczarek K, Pachota M, Plettenburg O, Potempa J, Rothenaigner I, Schlauderer F, Slysz K, Szczepanski A, Greve-Isdahl Mohn K, Blomberg B, Sattler M, Hadian K, Popowicz GM, Pyrc K
Publisher Correction: Self-association of MreC as a regulatory signal in bacterial cell wall elongation.
1. Nat Commun - published January 1, 2022
2. Martins A, Contreras-Martel C, Janet-Maitre M, Miyachiro MM, Estrozi LF, Trindade DM, Malospirito CC, Rodrigues-Costa F, Imbert L, Job V, Schoehn G, Attrée I, Dessen A
Design principles for site-selective hydroxylation by a Rieske oxygenase.
1. Nat Commun - published January 1, 2022
2. Liu J, Tian J, Perry C, Lukowski AL, Doukov TI, Narayan ARH, Bridwell-Rabb J
Simplified quality assessment for small-molecule ligands in the Protein Data Bank.
1. Structure - published January 1, 2022
2. Shao C, Westbrook JD, Lu C, Bhikadiya C, Peisach E, Young JY, Duarte JM, Lowe R, Wang S, Rose Y, Feng Z, Burley SK
The multiple molecular dimensions of long noncoding RNAs that regulate gene expression and tumorigenesis.
1. Curr Opin Oncol - published January 1, 2022
2. Marcia M
Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats.
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Nipah Virus V Protein Binding Alters MDA5 Helicase Folding Dynamics.
1. ACS Infect Dis - published January 1, 2022
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Time management for STEMM students during the continuing pandemic.
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Innovative vaccine approaches-a Keystone Symposia report.
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Author Correction: Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc.
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Aminopyridine analogs selectively target metastatic pancreatic cancer.
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2. Smalling RV, Bechard ME, Duryea J, Kingsley PJ, Roberts ER, Marnett LJ, Bilbao D, Stauffer SR, McDonald OG
Mapping the binding sites of UDP and prostaglandin E2 glyceryl ester in the nucleotide receptor P2Y6.
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ABCA7, a Genetic Risk Factor Associated with Alzheimer's Disease Risk in African Americans.
1. J Alzheimers Dis - published January 1, 2022
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Truncated PARP1 mediates ADP-ribosylation of RNA polymerase III for apoptosis.
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Erratum for Thorsen et al., "Highly Basic Clusters in the Herpes Simplex Virus 1 Nuclear Egress Complex Drive Membrane Budding by Inducing Lipid Ordering".
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Stabilization and structure determination of integral membrane proteins by termini restraining.
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Natural transformation protein ComFA exhibits single-stranded DNA translocase activity.
1. J Bacteriol - published January 1, 2022
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The anti-COVID-19 Drug Remdesivir Promotes Oncogenic Herpesviruses Reactivation through Regulation of Intracellular Signaling Pathways.
1. Antimicrob Agents Chemother - published January 1, 2022
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Listeria innocua isolated from diseased ruminants harbour minor virulence genes of L. monocytogenes.
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Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors.
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Mitoribosomal small subunit maturation involves formation of initiation-like complexes.
1. Proc Natl Acad Sci U S A - published January 1, 2022
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Insights into two-metal-ion catalytic mechanism of cap-snatching endonuclease of Ebinur Lake virus in Bunyavirales.
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Identification of a permissive secondary mutation that restores the enzymatic activity of oseltamivir resistance mutation H275Y.
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A Structure Is Worth a Thousand Words: New Insights for RAS and RAF Regulation.
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An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies.
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Predictable Clinical Benefits without Evidence of Synergy in Trials of Combination Therapies with Immune-Checkpoint Inhibitors.
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Crystal structure of the α_1B-adrenergic receptor reveals molecular determinants of selective ligand recognition.
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TRPV1 and Piezo: the 2021 Nobel Prize in Physiology or Medicine.
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Prostate secretory protein 94 (PSP94) inhibits sterol-binding and export by the mammalian CAP protein CRISP2 in a calcium-sensitive manner.
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NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems.
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Long-acting and extended-release implant and nanoformulations with a synergistic antiretroviral two-drug combination controls HIV-1 infection in a humanized mouse model.
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Surfactant protein C mutations and familial pulmonary fibrosis: stuck in a loop on the scenic route.
1. Eur Respir J - published January 1, 2022
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Spotlight on Nociceptin/Orphanin FQ Receptor in the Treatment of Pain.
1. Molecules - published January 1, 2022
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