Member Publications

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131 Member Publications for February 2021

Structural studies of full-length receptor tyrosine kinases and their implications for drug design.
1. Adv Protein Chem Struct Biol - published February 26, 2021
2. Bajinting A, Ng HL
Mechanism and ultrasensitivity in Hedgehog signaling revealed by Patched1 disease mutations.
1. Proc Natl Acad Sci U S A - published February 9, 2021
2. Petrov K, de Almeida Magalhaes T, Salic A
Ultrasound activates mechanosensitive TRAAK K⁺ channels through the lipid membrane.
1. Proc Natl Acad Sci U S A - published February 9, 2021
2. Sorum B, Rietmeijer RA, Gopakumar K, Adesnik H, Brohawn SG
On the Role of a Conserved Methionine in the Na⁺-Coupling Mechanism of a Neurotransmitter Transporter Homolog.
1. Neurochem Res - published February 9, 2021
2. Zhou W, Trinco G, Slotboom DJ, Forrest LR, Faraldo-Gómez JD
Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization.
1. Nat Rev Mol Cell Biol - published February 9, 2021
2. Lim CJ, Cech TR
Polymer Modification of Lipases, Substrate Interactions, and Potential Inhibition.
1. Biomacromolecules - published February 8, 2021
2. Rahman MS, Brown J, Murphy R, Carnes S, Carey B, Averick S, Konkolewicz D, Page RC
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.
1. Elife - published February 8, 2021
2. Uprety R, Che T, Zaidi SA, Grinnell SG, Varga BR, Faouzi A, Slocum ST, Allaoa A, Varadi A, Nelson M, Bernhard SM, Kulko E, Le Rouzic V, Eans SO, Simons CA, Hunkele A, Subrath J, Pan YX, Javitch JA, McLaughlin JP, Roth BL, Pasternak GW, Katritch V, Majumdar S
China's city-level carbon emissions during 1992-2017 based on the inter-calibration of nighttime light data.
1. Sci Rep - published February 8, 2021
2. Chen J, Gao M, Cheng S, Liu X, Hou W, Song M, Li D, Fan W
Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection.
1. Nat Commun - published February 8, 2021
2. Mulhall EM, Ward A, Yang D, Koussa MA, Corey DP, Wong WP
The assembly of β-barrel outer membrane proteins.
1. Curr Opin Microbiol - published February 6, 2021
2. Tomasek D, Kahne D
One Ring to Rule them All? Structural and Functional Diversity in the Nuclear Pore Complex.
1. Trends Biochem Sci - published February 6, 2021
2. Fernandez-Martinez J, Rout MP
Building Diverse Mentoring Networks that Transcend Boundaries in Cancer Research.
1. Trends Cancer - published February 6, 2021
2. Termini CM, Hinton AO Jr, Garza-López E, Koomoa DL, Davis JS, Martínez-Montemayor MM
Effects of Fe and Al ions during hydrogen sulphide (H₂S)-induced corrosion of tetracalcium aluminoferrite (C₄AF) and tricalcium aluminate (C₃A).
1. J Hazard Mater - published February 5, 2021
2. Mei K, Cheng X, Gu T, Zheng Y, Gong P, Li B, Zhang C, Zhang L, Dai B
Microcrystal Electron Diffraction Elucidates Water-Specific Polymorphism-Induced Emission Enhancement of Bis-arylacylhydrazone.
1. ACS Appl Mater Interfaces - published February 5, 2021
2. Cho HJ, Kim KS, Kim H, Kim T, Malyutin AG, Rees DC, Yoo BK, Song C
Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle.
1. Nat Commun - published February 5, 2021
2. Biebl MM, Lopez A, Rehn A, Freiburger L, Lawatscheck J, Blank B, Sattler M, Buchner J
Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate.
1. Nat Commun - published February 5, 2021
2. Fox JL, Hughes MA, Meng X, Sarnowska NA, Powley IR, Jukes-Jones R, Dinsdale D, Ragan TJ, Fairall L, Schwabe JWR, Morone N, Cain K, MacFarlane M
Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells.
1. Mol Cell - published February 4, 2021
2. Youmans DT, Gooding AR, Dowell RD, Cech TR
Disruption of the integrin-linked kinase (ILK) pseudokinase domain affects kidney development in mice.
1. J Biol Chem - published February 4, 2021
2. Bulus N, Brown KL, Mernaugh G, Böttcher A, Dong X, Sanders CR, Pozzi A, Fässler R, Zent R
Role of EIF4G1 network in non-small cell lung cancers (NSCLC) cell survival and disease progression.
1. J Cell Mol Med - published February 4, 2021
2. Del Valle L, Dai L, Lin HY, Lin Z, Chen J, Post SR, Qin Z
Gating the pore of the calcium-activated chloride channel TMEM16A.
1. Nat Commun - published February 4, 2021
2. Lam AKM, Rheinberger J, Paulino C, Dutzler R
Mechanism of pore opening in the calcium-activated chloride channel TMEM16A.
1. Nat Commun - published February 4, 2021
2. Lam AKM, Dutzler R
Multifunctional cellulases are potent, versatile tools for a renewable bioeconomy.
1. Curr Opin Biotechnol - published February 4, 2021
2. Glasgow E, Vander Meulen K, Kuch N, Fox BG
Mediator structure and conformation change.
1. Mol Cell - published February 4, 2021
2. Zhang H, Chen DH, Mattoo RUH, Bushnell DA, Wang Y, Yuan C, Wang L, Wang C, Davis RE, Nie Y, Kornberg RD
The Role of Methyl Groups in the Early Stage of Thermal Polymerization of Polycyclic Aromatic Hydrocarbons Revealed by Molecular Imaging.
1. Energy Fuels - published February 4, 2021
2. Chen P, Fatayer S, Schuler B, Metz JN, Gross L, Yao N, Zhang Y
Optimization of phase dispersion enables broadband excitation without homonuclear coupling artifacts.
1. J Magn Reson - published February 4, 2021
2. Coote P, Bermel W, Arthanari H
Biophysics of Notch Signaling.
1. Annu Rev Biophys - published February 3, 2021
2. Sprinzak D, Blacklow SC
Characterizing Native and Hydrocarbon-Stapled Enfuvirtide Conformations with Ion Mobility Mass Spectrometry and Hydrogen-Deuterium Exchange.
1. J Am Soc Mass Spectrom - published February 3, 2021
2. Stocks BB, Bird GH, Walensky LD, Melanson JE
Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo.
1. J Virol - published February 3, 2021
2. Gramatica A, Schwarzer R, Brantley W, Varco-Merth B, Sperber HS, Hull PA, Montano M, Migueles SA, Rosenthal D, Hogan LE, Johnson JR, Packard TA, Grimmett ZW, Herzig E, Besnard E, Nekorchuk M, Hsiao F, Deeks SG, Snape M, Kiernan B, Roan NR, Lifson JD, Estes JD, Picker LJ, Verdin E, Krogan NJ, Henrich TJ, Connors M, Ott M, Pillai SK, Okoye AA, Greene WC
Improving hindlimb locomotor function by Non-invasive AAV-mediated manipulations of propriospinal neurons in mice with complete spinal cord injury.
1. Nat Commun - published February 3, 2021
2. Brommer B, He M, Zhang Z, Yang Z, Page JC, Su J, Zhang Y, Zhu J, Gouy E, Tang J, Williams P, Dai W, Wang Q, Solinsky R, Chen B, He Z
A lamin A/C variant causing striated muscle disease provides insights into filament organization.
1. J Cell Sci - published February 3, 2021
2. Kronenberg-Tenga R, Tatli M, Eibauer M, Wu W, Shin JY, Bonne G, Worman HJ, Medalia O
Seroprevalence of SARS-CoV-2 Antibodies in Children and Adults in St. Louis, Missouri, USA.
1. mSphere - published February 3, 2021
2. Smith BK, Janowski AB, Danis JE, Harvey IB, Zhao H, Dai YN, Farnsworth CW, Gronowski AM, Roper S, Fremont DH, Wang D
A Secreted NlpC/P60 Endopeptidase from Photobacterium damselae subsp. piscicida Cleaves the Peptidoglycan of Potentially Competing Bacteria.
1. mSphere - published February 3, 2021
2. Lisboa J, Pereira C, Rifflet A, Ayala J, Terceti MS, Barca AV, Rodrigues I, Pereira PJB, Osorio CR, García-Del Portillo F, Gomperts Boneca I, do Vale A, Dos Santos NMS
Non-segmented negative-sense RNA viruses utilize N ⁶-methyladenosine (m⁶A) as a common strategy to evade host innate immunity.
1. J Virol - published February 3, 2021
2. Lu M, Xue M, Wang HT, Kairis EL, Ahmad S, Wei J, Zhang Z, Zhang Y, Gao Y, Garcin D, Peeples ME, Sharma A, Hur S, He C, Li J
RPA complexes in Caenorhabditis elegans meiosis; unique roles in replication, meiotic recombination and apoptosis.
1. Nucleic Acids Res - published February 2, 2021
2. Hefel A, Honda M, Cronin N, Harrell K, Patel P, Spies M, Smolikove S
GeneWalk identifies relevant gene functions for a biological context using network representation learning.
1. Genome Biol - published February 2, 2021
2. Ietswaart R, Gyori BM, Bachman JA, Sorger PK, Churchman LS
Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions.
1. ACS Infect Dis - published February 2, 2021
2. Ginn J, Jiang X, Sun S, Michino M, Huggins DJ, Mbambo Z, Jansen R, Rhee KY, Arango N, Lima CD, Liverton N, Imaeda T, Okamoto R, Kuroita T, Aso K, Stamford A, Foley M, Meinke PT, Nathan C, Bryk R
Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs.
1. Nat Commun - published February 2, 2021
2. Rudolph J, Roberts G, Luger K
Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design.
1. Sci Rep - published February 2, 2021
2. Amcheslavsky A, Wallace AL, Ejemel M, Li Q, McMahon CT, Stoppato M, Giuntini S, Schiller ZA, Pondish JR, Toomey JR, Schneider RM, Meisinger J, Heukers R, Kruse AC, Barry EM, Pierce BG, Klempner MS, Cavacini LA, Wang Y
Pseudomonas aeruginosa Uses c-di-GMP Phosphodiesterases RmcA and MorA To Regulate Biofilm Maintenance.
1. mBio - published February 2, 2021
2. Katharios-Lanwermeyer S, Whitfield GB, Howell PL, O'Toole GA
Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206.
1. J Biol Chem - published February 2, 2021
2. Feinberg H, Jégouzo SAF, Lasanajak Y, Smith DF, Drickamer K, Weis WI, Taylor ME
Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex.
1. Proc Natl Acad Sci U S A - published February 2, 2021
2. Xie W, Wang S, Wang J, de la Cruz MJ, Xu G, Scaltriti M, Patel DJ
Inhibitors of cullin-RING E3 ubiquitin ligase 4 with antitumor potential.
1. Proc Natl Acad Sci U S A - published February 2, 2021
2. Wu K, Huynh KQ, Lu I, Moustakim M, Miao H, Yu C, Haeusgen MJ, Hopkins BD, Huang L, Zheng N, Sanchez R, DeVita RJ, Pan ZQ
Identifying molecular features that are associated with biological function of intrinsically disordered protein regions.
1. Elife - published February 2, 2021
2. Zarin T, Strome B, Peng G, Pritišanac I, Forman-Kay JD, Moses AM
Inhibiting HTLV-1 Protease: A Viable Antiviral Target.
1. ACS Chem Biol - published February 2, 2021
2. Lockbaum GJ, Henes M, Talledge N, Rusere LN, Kosovrasti K, Nalivaika EA, Somasundaran M, Ali A, Mansky LM, Kurt Yilmaz N, Schiffer CA
Recognition of Histone H3 Methylation States by the PHD1 Domain of Histone Demethylase KDM5A.
1. ACS Chem Biol - published February 2, 2021
2. Longbotham JE, Kelly MJS, Fujimori DG
Antibody affinity versus dengue morphology influences neutralization.
1. PLoS Pathog - published February 2, 2021
2. Fibriansah G, Lim EXY, Marzinek JK, Ng TS, Tan JL, Huber RG, Lim XN, Chew VSY, Kostyuchenko VA, Shi J, Anand GS, Bond PJ, Crowe JE Jr, Lok SM
Comprehensive mutational analysis of the BRCA1-associated DNA helicase and tumor suppressor, FANCJ/BACH1/BRIP1.
1. Mol Cancer Res - published February 2, 2021
2. Calvo JA, Fritchman B, Hernandez D, Persky NS, Johannessen CM, Piccioni F, Kelch BA, Cantor SB
Local computational methods to improve the interpretability and analysis of cryo-EM maps.
1. Nat Commun - published February 2, 2021
2. Kaur S, Gomez-Blanco J, Khalifa AAZ, Adinarayanan S, Sanchez-Garcia R, Wrapp D, McLellan JS, Bui KH, Vargas J
Prolonged evolution of the human B cell response to SARS-CoV-2 infection.
1. Sci Immunol - published February 2, 2021
2. Sakharkar M, Rappazzo CG, Wieland-Alter WF, Hsieh CL, Wrapp D, Esterman ES, Kaku CI, Wec AZ, Geoghegan JC, McLellan JS, Connor RI, Wright PF, Walker LM
Crystallographic molecular replacement using an in silico-generated search model of SARS-CoV-2 ORF8.
1. Protein Sci - published February 2, 2021
2. Flower TG, Hurley JH
Liquid biopsy proteomics of uveal melanoma reveals biomarkers associated with metastatic risk.
1. Mol Cancer - published February 2, 2021
2. Velez G, Nguyen HV, Chemudupati T, Ludwig CA, Toral M, Reddy S, Mruthyunjaya P, Mahajan VB
A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis.
1. Nature - published February 2, 2021
2. Shen B, Tasdogan A, Ubellacker JM, Zhang J, Nosyreva ED, Du L, Murphy MM, Hu S, Yi Y, Kara N, Liu X, Guela S, Jia Y, Ramesh V, Embree C, Mitchell EC, Zhao YC, Ju LA, Hu Z, Crane GM, Zhao Z, Syeda R, Morrison SJ
Initiation of hepatitis C treatment in two rural Rwandan districts: a mobile clinic approach.
1. BMC Infect Dis - published February 2, 2021
2. Kamali I, Barnhart DA, Nyirahabihirwe F, de la Paix Gakuru J, Uwase M, Nizeyumuremyi E, Walker S, Mazimpaka C, de Dieu Gatete J, Makuza JD, Serumondo J, Kateera F, d'Amour Ndahimana J
Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of α-Helix As Oxyanion-Binding Site.
1. J Am Chem Soc - published February 2, 2021
2. Naudin EA, McEwen AG, Tan SK, Poussin-Courmontagne P, Schmitt JL, Birck C, DeGrado WF, Torbeev V
Hepatobiliary phenotypes of adults with alpha-1 antitrypsin deficiency.
1. Gut - published February 2, 2021
2. Fromme M, Schneider CV, Pereira V, Hamesch K, Pons M, Reichert MC, Benini F, Ellis P, H Thorhauge K, Mandorfer M, Burbaum B, Woditsch V, Chorostowska-Wynimko J, Verbeek J, Nevens F, Genesca J, Miravitlles M, Nuñez A, Schaefer B, Zoller H, Janciauskiene S, Abreu N, Jasmins L, Gaspar R, Gomes C, Schneider KM, Trauner M, Krag A, Gooptu B, Thorburn D, Marshall A, Hurst JR, Lomas DA, Lammert F, Gaisa NT, Clark V, Griffiths W, Trautwein C, Turner AM, McElvaney NG, Strnad P
Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors.
1. Prog Biophys Mol Biol - published February 2, 2021
2. Brosey CA, Houl JH, Katsonis P, Balapiti-Modarage LPF, Bommagani S, Arvai A, Moiani D, Bacolla A, Link T, Warden LS, Lichtarge O, Jones DE, Ahmed Z, Tainer JA
Autonomous Computing Materials.
1. ACS Nano - published February 2, 2021
2. Bathe M, Hernandez R, Komiyama T, Machiraju R, Neogi S
Characterization of two enzymes from Psychrobacter cryohalolentis that are required for the biosynthesis of an unusual diacetamido-d-sugar.
1. J Biol Chem - published February 2, 2021
2. Linehan MP, Thoden JB, Holden HM
Correction to: The model structure of the copper-dependent ammonia Monooxygenase.
1. J Biol Inorg Chem - published February 2, 2021
2. Musiani F, Broll V, Evangelisti E, Ciurli S
Tuning flavin environment to detect and control light-induced conformational switching in Drosophila cryptochrome.
1. Commun Biol - published February 2, 2021
2. Chandrasekaran S, Schneps CM, Dunleavy R, Lin C, DeOliveira CC, Ganguly A, Crane BR
Integrated control of surface adaptation by the bacterial flagellum.
1. Curr Opin Microbiol - published February 2, 2021
2. Hershey DM
Structural Determinants of Cholesterol Recognition in Helical Integral Membrane Proteins.
1. Biophys J - published February 2, 2021
2. Marlow B, Kuenze G, Li B, Sanders CR, Meiler J
Measuring gas vesicle dimensions by electron microscopy.
1. Protein Sci - published February 2, 2021
2. Dutka P, Malounda D, Metskas LA, Chen S, Hurt RC, Lu GJ, Jensen GJ, Shapiro MG
High-Throughput, Single-Copy Sequencing Reveals SARS-CoV-2 Spike Variants Coincident with Mounting Humoral Immunity during Acute COVID-19.
1. bioRxiv - published February 2, 2021
2. Ko SH, Mokhtari EB, Mudvari P, Stein S, Stringham CD, Wagner D, Ramelli S, Ramos-Benitez MJ, Strich JR, Davey RT Jr, Zhou T, Misasi J, Kwong PD, Chertow DS, Sullivan NJ, Boritz EA
Enhanced validation of small-molecule ligands and carbohydrates in the protein databank.
1. Structure - published February 2, 2021
2. Feng Z, Westbrook JD, Sala R, Smart OS, Bricogne G, Matsubara M, Yamada I, Tsuchiya S, Aoki-Kinoshita KF, Hoch JC, Kurisu G, Velankar S, Burley SK, Young JY
Genome oligopaint via local denaturation fluorescence in situ hybridization.
1. Mol Cell - published February 2, 2021
2. Wang Y, Cottle WT, Wang H, Feng XA, Mallon J, Gavrilov M, Bailey S, Ha T
Methylated HNRNPK acts on RPS19 to regulate ALOX15 synthesis in erythropoiesis.
1. Nucleic Acids Res - published February 2, 2021
2. Naarmann-de Vries IS, Senatore R, Moritz B, Marx G, Urlaub H, Niessing D, Ostareck DH, Ostareck-Lederer A
B cell engagement with HIV-1 founder virus envelope predicts development of broadly neutralizing antibodies.
1. Cell Host Microbe - published February 2, 2021
2. Townsley SM, Donofrio GC, Jian N, Leggat DJ, Dussupt V, Mendez-Rivera L, Eller LA, Cofer L, Choe M, Ehrenberg PK, Geretz A, Gift S, Grande R, Lee A, Peterson C, Piechowiak MB, Slike BM, Tran U, Joyce MG, Georgiev IS, Rolland M, Thomas R, Tovanabutra S, Doria-Rose NA, Polonis VR, Mascola JR, McDermott AB, Michael NL, Robb ML, Krebs SJ
Identification of Active Site Residues of the Siderophore Synthesis Enzyme PvdF and Evidence for Interaction of PvdF with a Substrate-Providing Enzyme.
1. Int J Mol Sci - published February 2, 2021
2. Philem P, Kleffmann T, Gai S, Hawkins BC, Wilbanks SM, Lamont IL
Facilitating Drug Discovery in Breast Cancer by Virtually Screening Patients Using In Vitro Drug Response Modeling.
1. Cancers (Basel) - published February 2, 2021
2. Gruener RF, Ling A, Chang YF, Morrison G, Geeleher P, Greene GL, Huang RS
Peptidomimetics Therapeutics for Retinal Disease.
1. Biomolecules - published February 2, 2021
2. Parsons DE, Lee SH, Sun YJ, Velez G, Bassuk AG, Smith M, Mahajan VB
Experimentally based structural model of Yih1 provides insight into its function in controlling the key translational regulator Gcn2.
1. FEBS Lett - published February 1, 2021
2. Harjes E, Jameson GB, Tu YH, Burr N, Loo TS, Goroncy AK, Edwards PJB, Harjes S, Munro B, Göbl C, Sattlegger E, Norris GE
Cyclic peptides bearing the d-Phe-2-Abz turn motif: Structural characterization and antimicrobial potential.
1. J Pept Sci - published February 1, 2021
2. Varnava KG, Edwards PJB, Cameron AJ, Harjes E, Sarojini V
High-efficacy subcellular micropatterning of proteins using fibrinogen anchors.
1. J Cell Biol - published February 1, 2021
2. Watson JL, Aich S, Oller-Salvia B, Drabek AA, Blacklow SC, Chin J, Derivery E
The impacts of COVID-19 vaccine timing, number of doses, and risk prioritization on mortality in the US.
1. medRxiv - published February 1, 2021
2. Wang X, Du Z, Johnson KE, Pasco RF, Fox SJ, Lachmann M, McLellan JS, Meyers LA
Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2.
1. ACS Infect Dis - published February 1, 2021
2. Nguyen W, Lee EF, Evangelista M, Lee M, Harris TJ, Colman PM, Smith NA, Williams LB, Jarman KE, Lowes KN, Haeberli C, Keiser J, Smith BJ, Fairlie WD, Sleebs BE
Integrating quantitative proteomics with accurate genome profiling of transcription factors by greenCUT&RUN.
1. Nucleic Acids Res - published February 1, 2021
2. Nizamuddin S, Koidl S, Bhuiyan T, Werner TV, Biniossek ML, Bonvin AMJJ, Lassmann S, Timmers H
Computation-guided optimization of split protein systems.
1. Nat Chem Biol - published February 1, 2021
2. Dolberg TB, Meger AT, Boucher JD, Corcoran WK, Schauer EE, Prybutok AN, Raman S, Leonard JN
Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7.
1. bioRxiv - published February 1, 2021
2. Wang P, Nair MS, Liu L, Iketani S, Luo Y, Guo Y, Wang M, Yu J, Zhang B, Kwong PD, Graham BS, Mascola JR, Chang JY, Yin MT, Sobieszczyk M, Kyratsous CA, Shapiro L, Sheng Z, Huang Y, Ho DD
The structure and ubiquitin binding properties of TRAF RING heterodimers.
1. J Mol Biol - published February 1, 2021
2. Das A, Middleton AJ, Padala P, Ledgerwood EC, Mace PD, Day CL
An Optical Fiber Sensor Based on Fluorescence Lifetime for the Determination of Sulfate Ions.
1. Sensors (Basel) - published February 1, 2021
2. Ding L, Gong P, Xu B, Ding Q
Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression.
1. Sci Adv - published February 1, 2021
2. Zhang K, Miorin L, Makio T, Dehghan I, Gao S, Xie Y, Zhong H, Esparza M, Kehrer T, Kumar A, Hobman TC, Ptak C, Gao B, Minna JD, Chen Z, García-Sastre A, Ren Y, Wozniak RW, Fontoura BMA
Targeting oncoproteins with a positive selection assay for protein degraders.
1. Sci Adv - published February 1, 2021
2. Koduri V, Duplaquet L, Lampson BL, Wang AC, Sabet AH, Ishoey M, Paulk J, Teng M, Harris IS, Endress JE, Liu X, Dasilva E, Paulo JA, Briggs KJ, Doench JG, Ott CJ, Zhang T, Donovan KA, Fischer ES, Gygi SP, Gray NS, Bradner J, Medin JA, Buhrlage SJ, Oser MG, Kaelin WG Jr
Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P)⁺-dependent malic enzyme.
1. iScience - published February 1, 2021
2. Hsieh JY, Yang HP, Tewary SK, Cheng HC, Liu YL, Tai SC, Chen WL, Hsu CH, Huang TJ, Chou CJ, Huang YN, Peng CT, Ho MC, Liu GY, Hung HC
Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates.
1. iScience - published February 1, 2021
2. Silva de Castro I, Gorini G, Mason R, Gorman J, Bissa M, Rahman MA, Arakelyan A, Kalisz I, Whitney S, Becerra-Flores M, Ni E, Peachman K, Trinh HV, Read M, Liu MH, Van Ryk D, Paquin-Proulx D, Shubin Z, Tuyishime M, Peele J, Ahmadi MS, Verardi R, Hill J, Beddall M, Nguyen R, Stamos JD, Fujikawa D, Min S, Schifanella L, Vaccari M, Galli V, Doster MN, Liyanage NPM, Sarkis S, Caccuri F, LaBranche C, Montefiori DC, Tomaras GD, Shen X, Rosati M, Felber BK, Pavlakis GN, Venzon DJ, Magnanelli W, Breed M, Kramer J, Keele BF, Eller MA, Cicala C, Arthos J, Ferrari G, Margolis L, Robert-Guroff M, Kwong PD, Roederer M, Rao M, Cardozo TJ, Franchini G
mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants.
1. Nature - published February 1, 2021
2. Wang Z, Schmidt F, Weisblum Y, Muecksch F, Barnes CO, Finkin S, Schaefer-Babajew D, Cipolla M, Gaebler C, Lieberman JA, Oliveira TY, Yang Z, Abernathy ME, Huey-Tubman KE, Hurley A, Turroja M, West KA, Gordon K, Millard KG, Ramos V, Silva JD, Xu J, Colbert RA, Patel R, Dizon J, Unson-O'Brien C, Shimeliovich I, Gazumyan A, Caskey M, Bjorkman PJ, Casellas R, Hatziioannou T, Bieniasz PD, Nussenzweig MC
Visualization of the mechanosensitive ion channel MscS under membrane tension.
1. Nature - published February 1, 2021
2. Zhang Y, Daday C, Gu RX, Cox CD, Martinac B, de Groot BL, Walz T
Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex.
1. Genes Dev - published February 1, 2021
2. Schnabl J, Wang J, Hohmann U, Gehre M, Batki J, Andreev VI, Purkhauser K, Fasching N, Duchek P, Novatchkova M, Mechtler K, Plaschka C, Patel DJ, Brennecke J
Self-assembly and regulation of protein cages from pre-organised coiled-coil modules.
1. Nat Commun - published February 1, 2021
2. Lapenta F, Aupič J, Vezzoli M, Strmšek Ž, Da Vela S, Svergun DI, Carazo JM, Melero R, Jerala R
siRNAs containing 2'-fluorinated Northern-methanocarbacyclic (2'-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2'-F-NMC NTPs.
1. Nucleic Acids Res - published February 1, 2021
2. Akabane-Nakata M, Erande ND, Kumar P, Degaonkar R, Gilbert JA, Qin J, Mendez M, Woods LB, Jiang Y, Janas MM, O'Flaherty DK, Zlatev I, Schlegel MK, Matsuda S, Egli M, Manoharan M
EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction.
1. Nat Commun - published February 1, 2021
2. Zhao J, Blayney A, Liu X, Gandy L, Jin W, Yan L, Ha JH, Canning AJ, Connelly M, Yang C, Liu X, Xiao Y, Cosgrove MS, Solmaz SR, Zhang Y, Ban D, Chen J, Loh SN, Wang C
Mechanism of karyopherin-β2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X).
1. Sci Rep - published February 1, 2021
2. Gonzalez A, Mannen T, Çağatay T, Fujiwara A, Matsumura H, Niesman AB, Brautigam CA, Chook YM, Yoshizawa T
C. elegans germ granules require both assembly and localized regulators for mRNA repression.
1. Nat Commun - published February 1, 2021
2. Aoki ST, Lynch TR, Crittenden SL, Bingman CA, Wickens M, Kimble J
Impact of in-cell and in-vitro crowding on the conformations and dynamics of an intrinsically disordered protein.
1. Angew Chem Int Ed Engl - published February 1, 2021
2. Schuler B, König I, Soranno A, Nettels D
Modular Imaging Scaffold for Single-Particle Electron Microscopy.
1. ACS Nano - published February 1, 2021
2. Aissaoui N, Lai-Kee-Him J, Mills A, Declerck N, Morichaud Z, Brodolin K, Baconnais S, Le Cam E, Charbonnier JB, Sounier R, Granier S, Ropars V, Bron P, Bellot G
Correction to: The structure-based reaction mechanism of urease, a nickel dependent enzyme: tale of a long debate.
1. J Biol Inorg Chem - published February 1, 2021
2. Mazzei L, Musiani F, Ciurli S
Humoral signatures of protective and pathological SARS-CoV-2 infection in children.
1. Nat Med - published February 1, 2021
2. Bartsch YC, Wang C, Zohar T, Fischinger S, Atyeo C, Burke JS, Kang J, Edlow AG, Fasano A, Baden LR, Nilles EJ, Woolley AE, Karlson EW, Hopke AR, Irimia D, Fischer ES, Ryan ET, Charles RC, Julg BD, Lauffenburger DA, Yonker LM, Alter G
Machine learning identifies candidates for drug repurposing in Alzheimer's disease.
1. Nat Commun - published February 1, 2021
2. Rodriguez S, Hug C, Todorov P, Moret N, Boswell SA, Evans K, Zhou G, Johnson NT, Hyman BT, Sorger PK, Albers MW, Sokolov A
Structural basis of Stu2 recruitment to yeast kinetochores.
1. Elife - published February 1, 2021
2. Zahm JA, Stewart MG, Carrier JS, Harrison SC, Miller MP
Illuminating the dark conformational space of macrocycles using dominant rotors.
1. Nat Chem - published February 1, 2021
2. Diaz DB, Appavoo SD, Bogdanchikova AF, Lebedev Y, McTiernan TJ, Dos Passos Gomes G, Yudin AK
Supermolecule Cucurbituril Subnanoporous Carbon Supercapacitor (SCSCS).
1. Nano Lett - published February 1, 2021
2. Cui J, Yin J, Meng J, Liu Y, Liao M, Wu T, Dresselhaus M, Xie Y, Wu J, Lu C, Zhang X
DNA Sequence Modulates the Efficiency of NEIL1-Catalyzed Excision of the Aflatoxin B₁-Induced Formamidopyrimidine Guanine Adduct.
1. Chem Res Toxicol - published February 1, 2021
2. Tomar R, Minko IG, Kellum AH Jr, Voehler MW, Stone MP, McCullough AK, Lloyd RS
Highly Selective Y₄ Receptor Antagonist Binds in an Allosteric Binding Pocket.
1. J Med Chem - published February 1, 2021
2. Schüß C, Vu O, Schubert M, Du Y, Mishra NM, Tough IR, Stichel J, Weaver CD, Emmitte KA, Cox HM, Meiler J, Beck-Sickinger AG
Identifying Poly(ADP-ribose)-Binding Proteins with Photoaffinity-Based Proteomics.
1. J Am Chem Soc - published February 1, 2021
2. Dasovich M, Beckett MQ, Bailey S, Ong SE, Greenberg MM, Leung AKL
Morphological bases of phytoplankton energy management and physiological responses unveiled by 3D subcellular imaging.
1. Nat Commun - published February 1, 2021
2. Uwizeye C, Decelle J, Jouneau PH, Flori S, Gallet B, Keck JB, Bo DD, Moriscot C, Seydoux C, Chevalier F, Schieber NL, Templin R, Allorent G, Courtois F, Curien G, Schwab Y, Schoehn G, Zeeman SC, Falconet D, Finazzi G
Activating sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis.
1. Cancer Lett - published February 1, 2021
2. Chen YC, Dinavahi SS, Feng Q, Gowda R, Ramisetti S, Xia X, LaPenna KB, Chirasani VR, Cho SH, Hafenstein SL, Battu MB, Berg A, Sharma AK, Kirchhausen T, Dokholyan NV, Amin S, He P, Robertson GP
Disease-linked super-trafficking of a potassium channel.
1. J Biol Chem - published February 1, 2021
2. Huang H, Chamness LM, Vanoye CG, Kuenze G, Meiler J, George AL Jr, Schlebach JP, Sanders CR
Limited effects of long-term daily cranberry consumption on the gut microbiome in a placebo-controlled study of women with recurrent urinary tract infections.
1. BMC Microbiol - published February 1, 2021
2. Straub TJ, Chou WC, Manson AL, Schreiber HL 4th, Walker BJ, Desjardins CA, Chapman SB, Kaspar KL, Kahsai OJ, Traylor E, Dodson KW, Hullar MAJ, Hultgren SJ, Khoo C, Earl AM
FARS1-related disorders caused by bi-allelic mutations in cytosolic phenylalanyl- tRNA synthetase genes: look beyond the lungs!
1. Clin Genet - published February 1, 2021
2. Schuch Luise A, Forstner M, Rapp Christina K, Li Y, Smith Desiree EC, Mendes Marisa I, Delhommel F, Sattler M, Emiralioğlu N, Taskiran Ekim Z, Orhan D, Kiper N, Rohlfs M, Jeske T, Hastreiter M, Gerstlauer M, Torrent-Vernetta A, Moreno-Galdó A, Kammer B, Brasch F, Reu-Hofer S, Griese M
Phospho-dependent Signaling during the General Stress Response by the Atypical Response Regulator and ClpXP Adaptor RssB.
1. Protein Sci - published February 1, 2021
2. Schwartz J, Son J, Brugger C, Deaconescu AM
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing.
1. Mol Cell - published February 1, 2021
2. Zhou W, Mohr L, Maciejowski J, Kranzusch PJ
Signaling at the endosome: cryo-EM structure of a GPCR-G protein-beta-arrestin megacomplex.
1. FEBS J - published February 1, 2021
2. Nguyen AH, Lefkowitz RJ
Virus-derived peptide inhibitors of the herpes simplex virus type 1 nuclear egress complex.
1. Sci Rep - published February 1, 2021
2. Draganova EB, Heldwein EE
Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells.
1. Cell - published February 1, 2021
2. Glassman CR, Mathiharan YK, Jude KM, Su L, Panova O, Lupardus PJ, Spangler JB, Ely LK, Thomas C, Skiniotis G, Garcia KC
Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead.
1. ACS Med Chem Lett - published February 1, 2021
2. Ippolito JA, Niu H, Bertoletti N, Carter ZJ, Jin S, Spasov KA, Cisneros JA, Valhondo M, Cutrona KJ, Anderson KS, Jorgensen WL
Eltrombopag directly inhibits BAX and prevents cell death.
1. Nat Commun - published February 1, 2021
2. Spitz AZ, Zacharioudakis E, Reyna DE, Garner TP, Gavathiotis E
Molecular structures of the eukaryotic retinal importer ABCA4.
1. Elife - published February 1, 2021
2. Liu F, Lee J, Chen J
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
1. Nat Commun - published February 1, 2021
2. Tran TH, Chan AH, Young LC, Bindu L, Neale C, Messing S, Dharmaiah S, Taylor T, Denson JP, Esposito D, Nissley DV, Stephen AG, McCormick F, Simanshu DK
Salmonella enterica BcfH is a trimeric thioredoxin-like bifunctional enzyme with both thiol oxidase and disulfide isomerase activities.
1. Antioxid Redox Signal - published February 1, 2021
2. Subedi P, Paxman JJ, Wang G, Hor L, Hong Y, Verderosa AD, Whitten AE, Panjikar S, Santos-Martin CF, Martin JL, Totsika M, Heras B
Assessing optimal: inequalities in codon optimization algorithms.
1. BMC Biol - published February 1, 2021
2. Ranaghan MJ, Li JJ, Laprise DM, Garvie CW
Publisher Correction: Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization.
1. Nat Rev Mol Cell Biol - published February 1, 2021
2. Lim CJ, Cech TR
CorRelator: Interactive software for real-time high precision cryo-correlative light and electron microscopy.
1. J Struct Biol - published February 1, 2021
2. Yang JE, Larson MR, Sibert BS, Shrum S, Wright ER
Delivery of recombinant SARS-CoV-2 envelope protein into human cells.
1. bioRxiv - published February 1, 2021
2. Hutchison JM, Capone R, Luu DD, Hadziselimovic A, Van Horn WD, Sanders CR
Cryo-EM structure of a proton-activated chloride channel TMEM206.
1. Sci Adv - published February 1, 2021
2. Deng Z, Zhao Y, Feng J, Zhang J, Zhao H, Rau MJ, Fitzpatrick JAJ, Hu H, Yuan P
Administration of high titer convalescent anti-SARS-CoV-2 plasma: From donor selection to monitoring recipient outcomes.
1. Hum Immunol - published February 1, 2021
2. Mendoza RP, Fyke W, Daniel D, Gabutan E, Das B, Bajaj H, Easy M, Vasileva A, Colbourn R, Alawad M, Dehghani A, Lin B, Emechebe D, Patel P, Jabbar A, Nikolov DB, Giovaniello D, Kang S, Tatem L, Bromberg K, Augenbraun M, Premsrirut P, Libien J, Norin AJ
Structural mechanisms of gating and selectivity of human rod CNGA1 channel.
1. Neuron - published February 1, 2021
2. Xue J, Han Y, Zeng W, Wang Y, Jiang Y
Accuracy and comparison of two rapid multiplex PCR tests for gastroenteritis pathogens: a systematic review and meta-analysis.
1. BMJ Open Gastroenterol - published February 1, 2021
2. Chang LJ, Hsiao CJ, Chen B, Liu TY, Ding J, Hsu WT, Su-Ortiz V, Chen ST, Su KY, Wu HP, Lee CC
Cryo-EM catalyzes the exploration of drug selectivity: the CDK7 inhibitor example.
1. Biophys J - published February 1, 2021
2. Samsó M
Small-Angle X-ray Scattering Models of APOBEC3B Catalytic Domain in a Complex with a Single-Stranded DNA Inhibitor.
1. Viruses - published February 1, 2021
2. Barzak FM, Ryan TM, Kvach MV, Kurup HM, Aihara H, Harris RS, Filichev VV, Harjes E, Jameson GB
Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection.
1. Cell - published February 1, 2021
2. Winkler ES, Gilchuk P, Yu J, Bailey AL, Chen RE, Chong Z, Zost SJ, Jang H, Huang Y, Allen JD, Case JB, Sutton RE, Carnahan RH, Darling TL, Boon ACM, Mack M, Head RD, Ross TM, Crowe JE Jr, Diamond MS
Genetics of Uveitis.
1. Ocul Immunol Inflamm - published February 1, 2021
2. Cunningham ET Jr, Pichi F, Mahajan VB, Rosenbaum JT, Zierhut M