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178 Member Publications for March 2021

The Molecular Function of PURA and Its Implications in Neurological Diseases.
1. Front Genet - published March 29, 2021
2. Molitor L, Bacher S, Burczyk S, Niessing D
Minerva: a light-weight, narrative image browser for multiplexed tissue images.
1. J Open Source Softw - published March 26, 2021
2. Hoffer J, Rashid R, Muhlich JL, Chen YA, Russell DPW, Ruokonen J, Krueger R, Pfister H, Santagata S, Sorger PK
Structure of the EphB6 receptor ectodomain.
1. PLoS One - published March 26, 2021
2. Mason EO, Goldgur Y, Robev D, Freywald A, Nikolov DB, Himanen JP
Redox-sensitive carrier-free nanoparticles self-assembled by disulfide-linked paclitaxel-tetramethylpyrazine conjugate for combination cancer chemotherapy.
1. Theranostics - published March 23, 2021
2. Zou L, Liu X, Li J, Li W, Zhang L, Fu C, Zhang J, Gu Z
Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds.
1. RSC Adv - published March 18, 2021
2. Carrasquel-Ursulaez W, Reeves RD, Dehghany M, Jones C, Schomaker JM, Chanda B
Polarization Effects in Water-Mediated Selective Cation Transport across a Narrow Transmembrane Channel.
1. J Chem Theory Comput - published March 9, 2021
2. Ngo V, Li H, MacKerell AD Jr, Allen TW, Roux B, Noskov S
Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.
1. Proc Natl Acad Sci U S A - published March 9, 2021
2. Ahmed MS, Wang P, Nguyen NUN, Nakada Y, Menendez-Montes I, Ismail M, Bachoo R, Henkemeyer M, Sadek HA, Kandil ES
Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3.
1. Proc Natl Acad Sci U S A - published March 9, 2021
2. Qiu M, Glass Z, Chen J, Haas M, Jin X, Zhao X, Rui X, Ye Z, Li Y, Zhang F, Xu Q
Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2.
1. Proc Natl Acad Sci U S A - published March 9, 2021
2. Pei J, Wagner ND, Zou AJ, Chatterjee S, Borek D, Cole AR, Kim PJ, Basler CF, Otwinowski Z, Gross ML, Amarasinghe GK, Leung DW
Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody.
1. Proc Natl Acad Sci U S A - published March 9, 2021
2. Madan B, Zhang B, Xu K, Chao CW, O'Dell S, Wolfe JR, Chuang GY, Fahad AS, Geng H, Kong R, Louder MK, Nguyen TD, Rawi R, Schön A, Sheng Z, Nimrania R, Wang Y, Zhou T, Lin BC, Doria-Rose NA, Shapiro L, Kwong PD, DeKosky BJ
Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation.
1. Proc Natl Acad Sci U S A - published March 9, 2021
2. Patil K, Jordan EJ, Park JH, Suresh K, Smith CM, Lemmon AA, Mossé YP, Lemmon MA, Radhakrishnan R
Mapping the functional landscape of the receptor binding domain of T7 bacteriophage by deep mutational scanning.
1. Elife - published March 9, 2021
2. Huss P, Meger A, Leander M, Nishikawa KK, Raman S
Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery.
1. Immunity - published March 9, 2021
2. Chiou SH, Tseng D, Reuben A, Mallajosyula V, Molina IS, Conley S, Wilhelmy J, McSween AM, Yang X, Nishimiya D, Sinha R, Nabet BY, Wang C, Shrager JB, Berry MF, Backhus L, Lui NS, Wakelee HA, Neal JW, Padda SK, Berry GJ, Delaidelli A, Sorensen PH, Sotillo E, Tran P, Benson JA, Richards R, Labanieh L, Klysz DD, Louis DM, Feldman SA, Diehn M, Weissman IL, Zhang J, Wistuba II, Futreal PA, Heymach JV, Garcia KC, Mackall CL, Davis MM
Itaconate confers tolerance to late NLRP3 inflammasome activation.
1. Cell Rep - published March 9, 2021
2. Bambouskova M, Potuckova L, Paulenda T, Kerndl M, Mogilenko DA, Lizotte K, Swain A, Hayes S, Sheldon RD, Kim H, Kapadnis U, Ellis AE, Isaguirre C, Burdess S, Laha A, Amarasinghe GK, Chubukov V, Roddy TP, Diamond MS, Jones RG, Simons DM, Artyomov MN
Full methylation of H3K27 by PRC2 is dispensable for initial embryoid body formation but required to maintain differentiated cell identity.
1. Development - published March 9, 2021
2. Miller SA, Damle M, Kim J, Kingston RE
Maternal Iron Deficiency Modulates Placental Transcriptome and Proteome in Mid-Gestation of Mouse Pregnancy.
1. J Nutr - published March 9, 2021
2. Cao C, Prado MA, Sun L, Rockowitz S, Sliz P, Paulo JA, Finley D, Fleming MD
Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery.
1. Immunity - published March 9, 2021
2. Clement CC, Nanaware PP, Yamazaki T, Negroni MP, Ramesh K, Morozova K, Thangaswamy S, Graves A, Kim HJ, Li TW, Vigano' M, Soni RK, Gadina M, Tse HY, Galluzzi L, Roche PA, Denzin LK, Stern LJ, Santambrogio L
Single-Shot Vaccines against Bovine Respiratory Syncytial Virus (BRSV): Comparative Evaluation of Long-Term Protection after Immunization in the Presence of BRSV-Specific Maternal Antibodies.
1. Vaccines (Basel) - published March 9, 2021
2. Valarcher JF, Hägglund S, Näslund K, Jouneau L, Malmström E, Boulesteix O, Pinard A, Leguéré D, Deslis A, Gauthier D, Dubuquoy C, Pietralunga V, Rémot A, Falk A, Shevchenko G, Bergström Lind S, Von Brömssen C, Vargmar K, Zhang B, Kwong PD, Rodriguez MJ, Garcia Duran M, Schwartz-Cornil I, Taylor G, Riffault S
HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase.
1. Elife - published March 8, 2021
2. Rudolph J, Roberts G, Muthurajan UM, Luger K
Structural basis of the human Scribble-Vangl2 association in health and disease.
1. Biochem J - published March 8, 2021
2. How JY, Stephens R, Lim KYB, Humbert PO, Kvansakul M
Cryo-EM structures of human coagulation factors V and Va.
1. Blood - published March 8, 2021
2. Ruben EA, Rau MJ, Fitzpatrick J, Di Cera E
Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7.
1. Nature - published March 8, 2021
2. Wang P, Nair MS, Liu L, Iketani S, Luo Y, Guo Y, Wang M, Yu J, Zhang B, Kwong PD, Graham BS, Mascola JR, Chang JY, Yin MT, Sobieszczyk M, Kyratsous CA, Shapiro L, Sheng Z, Huang Y, Ho DD
NMR and EPR reveal a compaction of the RNA-binding protein FUS upon droplet formation.
1. Nat Chem Biol - published March 8, 2021
2. Emmanouilidis L, Esteban-Hofer L, Damberger FF, de Vries T, Nguyen CKX, Ibáñez LF, Mergenthal S, Klotzsch E, Yulikov M, Jeschke G, Allain FH
Structure of the FA core ubiquitin ligase closing the ID clamp on DNA.
1. Nat Struct Mol Biol - published March 8, 2021
2. Wang S, Wang R, Peralta C, Yaseen A, Pavletich NP
Efficient and flexible synthesis of new photoactivatable propofol analogs.
1. Bioorg Med Chem Lett - published March 8, 2021
2. Skinner KA, Wzorek JS, Kahne D, Gaudet R
Conformational dynamics in interleukin 17A and 17F functional complexes is a key determinant of receptor A affinity and specificity.
1. Cytokine - published March 8, 2021
2. Waters LC, Veverka V, Strong SL, Muskett FW, Dedi N, Lawson ADG, Prosser CE, Taylor RJ, Henry AJ, Carr MD
Oligomeric complexes formed by Redβ single strand annealing protein in its different DNA bound states.
1. Nucleic Acids Res - published March 8, 2021
2. Caldwell BJ, Norris A, Zakharova E, Smith CE, Wheat CT, Choudhary D, Sotomayor M, Wysocki VH, Bell CE
Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies.
1. bioRxiv - published March 8, 2021
2. Muecksch F, Weisblum Y, Barnes CO, Schmidt F, Schaefer-Babajew D, Lorenzi JCC, Flyak AI, DeLaitsch AT, Huey-Tubman KE, Hou S, Schiffer CA, Gaebler C, Wang Z, Da Silva J, Poston D, Finkin S, Cho A, Cipolla M, Oliveira TY, Millard KG, Ramos V, Gazumyan A, Rutkowska M, Caskey M, Nussenzweig MC, Bjorkman PJ, Hatziioannou T, Bieniasz PD
Engineering of Challenging G Protein-Coupled Receptors for Structure Determination and Biophysical Studies.
1. Molecules - published March 8, 2021
2. Waltenspühl Y, Ehrenmann J, Klenk C, Plückthun A
Pirtobrutinib in relapsed or refractory B-cell malignancies (BRUIN): a phase 1/2 study.
1. Lancet - published March 6, 2021
2. Mato AR, Shah NN, Jurczak W, Cheah CY, Pagel JM, Woyach JA, Fakhri B, Eyre TA, Lamanna N, Patel MR, Alencar A, Lech-Maranda E, Wierda WG, Coombs CC, Gerson JN, Ghia P, Le Gouill S, Lewis DJ, Sundaram S, Cohen JB, Flinn IW, Tam CS, Barve MA, Kuss B, Taylor J, Abdel-Wahab O, Schuster SJ, Palomba ML, Lewis KL, Roeker LE, Davids MS, Tan XN, Fenske TS, Wallin J, Tsai DE, Ku NC, Zhu E, Chen J, Yin M, Nair B, Ebata K, Marella N, Brown JR, Wang M
In vitro and in vivo inhibition of malaria parasite infection by monoclonal antibodies against Plasmodium falciparum circumsporozoite protein (CSP).
1. Sci Rep - published March 5, 2021
2. Livingstone MC, Bitzer AA, Giri A, Luo K, Sankhala RS, Choe M, Zou X, Dennison SM, Li Y, Washington W, Ngauy V, Tomaras GD, Joyce MG, Batchelor AH, Dutta S
A "Drug Sweeping" State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa.
1. Structure - published March 4, 2021
2. Fabre L, Ntreh AT, Yazidi A, Leus IV, Weeks JW, Bhattacharyya S, Ruickoldt J, Rouiller I, Zgurskaya HI, Sygusch J
Defective lysosomal storage in Fabry Disease modifies mitochondrial structure, metabolism and turnover in renal epithelial cells.
1. J Inherit Metab Dis - published March 4, 2021
2. Schumann A, Schaller K, Belche V, Cybulla M, Grünert SC, Moers N, Sass JO, Kaech A, Hannibal L, Spiekerkoetter U
Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.
1. PLoS One - published March 4, 2021
2. Cohen AA, Yang Z, Gnanapragasam PNP, Ou S, Dam KA, Wang H, Bjorkman PJ
Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity.
1. Genome Biol - published March 4, 2021
2. Sorek M, Oweis W, Nissim-Rafinia M, Maman M, Simon S, Hession CC, Adiconis X, Simmons SK, Sanjana NE, Shi X, Lu C, Pan JQ, Xu X, Pouladi MA, Ellerby LM, Zhang F, Levin JZ, Meshorer E
Integrated genomic analysis reveals regulatory pathways and dynamic landscapes of the tRNA transcriptome.
1. Sci Rep - published March 4, 2021
2. Sun Z, Tan J, Zhao M, Peng Q, Zhou M, Zuo S, Wu F, Li X, Dong Y, Xie M, Yang Y, Zhou J, Liu X, He Q, He Z, Yu X, He Q
Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies.
1. Nat Med - published March 4, 2021
2. Chen RE, Zhang X, Case JB, Winkler ES, Liu Y, VanBlargan LA, Liu J, Errico JM, Xie X, Suryadevara N, Gilchuk P, Zost SJ, Tahan S, Droit L, Turner JS, Kim W, Schmitz AJ, Thapa M, Wang D, Boon ACM, Presti RM, O'Halloran JA, Kim AHJ, Deepak P, Pinto D, Fremont DH, Crowe JE Jr, Corti D, Virgin HW, Ellebedy AH, Shi PY, Diamond MS
N-terminal transmembrane-helix epitope tag for x-ray crystallography and electron microscopy of small membrane proteins.
1. J Mol Biol - published March 4, 2021
2. McIlwain BC, Erwin AL, Davis AR, Ben Koff B, Chang L, Bylund T, Chuang GY, Kwong PD, Ohi MD, Lai YT, Stockbridge RB
An unexpected P-cluster like intermediate en route to the nitrogenase FeMo-co.
1. Chem Sci - published March 4, 2021
2. Jenner LP, Cherrier MV, Amara P, Rubio LM, Nicolet Y
Dual role of endothelial Myct1 in tumor angiogenesis and tumor immunity.
1. Sci Transl Med - published March 3, 2021
2. Kabir AU, Subramanian M, Lee DH, Wang X, Krchma K, Wu J, Naismith T, Halabi CM, Kim JY, Pulous FE, Petrich BG, Kim S, Park HC, Hanson PI, Pan H, Wickline SA, Fremont DH, Park C, Choi K
Structural insights into the inhibition of glycine reuptake.
1. Nature - published March 3, 2021
2. Shahsavar A, Stohler P, Bourenkov G, Zimmermann I, Siegrist M, Guba W, Pinard E, Sinning S, Seeger MA, Schneider TR, Dawson RJP, Nissen P
Allogeneic transplantation after PD-1 blockade for classic Hodgkin lymphoma.
1. Leukemia - published March 3, 2021
2. Merryman RW, Castagna L, Giordano L, Ho VT, Corradini P, Guidetti A, Casadei B, Bond DA, Jaglowski S, Spinner MA, Arai S, Lowsky R, Shah GL, Perales MA, De Colella JMS, Blaise D, Herrera AF, Shouse G, Spilleboudt C, Ansell SM, Nieto Y, Badar T, Hamadani M, Feldman TA, Dahncke L, Singh AK, McGuirk JP, Nishihori T, Chavez J, Serritella AV, Kline J, Mohty M, Dulery R, Stamatoulas A, Houot R, Manson G, Moles-Moreau MP, Orvain C, Bouabdallah K, Modi D, Ramchandren R, Lekakis L, Beitinjaneh A, Frigault MJ, Chen YB, Lynch RC, Smith SD, Rao U, Byrne M, Romancik JT, Cohen JB, Nathan S, Phillips T, Joyce RM, Rahimian M, Bashey A, Ballard HJ, Svoboda J, Torri V, Sollini M, De Philippis C, Magagnoli M, Santoro A, Armand P, Zinzani PL, Carlo-Stella C
Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates.
1. Sci Transl Med - published March 3, 2021
2. Darricarrère N, Qiu Y, Kanekiyo M, Creanga A, Gillespie RA, Moin SM, Saleh J, Sancho J, Chou TH, Zhou Y, Zhang R, Dai S, Moody A, Saunders KO, Crank MC, Mascola JR, Graham BS, Wei CJ, Nabel GJ
An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation.
1. Prog Biophys Mol Biol - published March 3, 2021
2. Nguyen MT, Moiani D, Ahmed Z, Arvai AS, Namjoshi S, Shin DS, Fedorov Y, Selvik EJ, Jones DE, Pink J, Yan Y, Laverty DJ, Nagel ZD, Tainer JA, Gerson SL
DeepAlign, a 3D Alignment Method based on Regionalized Deep Learning for Cryo-EM.
1. J Struct Biol - published March 3, 2021
2. Jiménez-Moreno A, Střelák D, Filipovič J, Carazo JM, Sorzano COS
Intestinal host response to SARS-CoV-2 infection and COVID-19 outcomes in patients with gastrointestinal symptoms.
1. Gastroenterology - published March 3, 2021
2. Livanos AE, Jha D, Cossarini F, Gonzalez-Reiche AS, Tokuyama M, Aydillo T, Parigi TL, Ladinsky MS, Ramos I, Dunleavy K, Lee B, Dixon R, Chen ST, Martinez-Delgado G, Nagula S, Bruce EA, Ko HM, Glicksberg BS, Nadkarni G, Pujadas E, Reidy J, Naymagon S, Grinspan A, Ahmad J, Tankelevich M, Bram Y, Gordon R, Sharma K, Houldsworth J, Britton GJ, Chen-Liaw A, Spindler MP, Plitt T, Wang P, Cerutti A, Faith JJ, Colombel JF, Kenigsberg E, Argmann C, Merad M, Gnjatic S, Harpaz N, Danese S, Cordon-Cardo C, Rahman A, Schwartz RE, Kumta NA, Aghemo A, Bjorkman PJ, Petralia F, van Bakel H, Garcia-Sastre A, Mehandru S
Crystal structures of influenza nucleoprotein complexed with nucleic acid provide insights into the mechanism of RNA interaction.
1. Nucleic Acids Res - published March 3, 2021
2. Tang YS, Xu S, Chen YW, Wang JH, Shaw PC
Intrapleural Fibrinolytics and Deoxyribonuclease for Treatment of Indwelling Pleural Catheter-Related Pleural Infection: A Multi-Center Observational Study.
1. Respiration - published March 3, 2021
2. Fitzgerald DB, Muruganandan S, Tsim S, Ip H, Asciak R, Walker S, Uribe Becerra JP, Majid A, Ahmed L, Rahman NM, Maskell NA, Blyth KG, Lee YCG
Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling.
1. J Clin Invest - published March 3, 2021
2. Munshaw S, Bruche S, Redpath AN, Jones A, Patel J, Dubé KN, Lee R, Hester SS, Davies R, Neal G, Handa A, Sattler M, Fischer R, Channon KM, Smart N
Crystal structure of an inulosucrase from Halalkalicoccus jeotgali B3T-a halophilic archaeal strain.
1. FEBS J - published March 3, 2021
2. Ghauri K, Pijning T, Munawar N, Ali H, Ghauri MA, Anwar MA, Wallis R
Structural Mechanisms for Replicating DNA in Eukaryotes.
1. Annu Rev Biochem - published March 3, 2021
2. Attali I, Botchan MR, Berger JM
A positively charged surface patch on the pestivirus NS3 protease module plays an important role in modulating NS3 helicase activity and virus production.
1. Arch Virol - published March 3, 2021
2. Zheng F, Yi W, Liu W, Zhu H, Gong P, Pan Z
Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2.
1. Elife - published March 3, 2021
2. Xie Y, Clarke BP, Kim YJ, Ivey AL, Hill PS, Shi Y, Ren Y
Arf1 orchestrates Rab GTPase conversion at the trans-Golgi network.
1. Mol Biol Cell - published March 3, 2021
2. Thomas LL, Highland CM, Fromme JC
Peripheral Methionine Residues Impact Flavin Photoreduction and Protonation in an Engineered LOV Domain Light Sensor.
1. Biochemistry - published March 3, 2021
2. Yee EF, Oldemeyer S, Böhm E, Ganguly A, York DM, Kottke T, Crane BR
Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons.
1. Cell Rep - published March 3, 2021
2. Ipsaro JJ, O'Brien PA, Bhattacharya S, Palmer AG 3rd, Joshua-Tor L
Arf1 directly recruits the Pik1-Frq1 PI4K complex to regulate the final stages of Golgi maturation.
1. Mol Biol Cell - published March 3, 2021
2. Highland CM, Fromme JC
Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice.
1. Sci Transl Med - published March 3, 2021
2. Ito N, Riyadh MA, Ahmad SAI, Hattori S, Kanemura Y, Kiyonari H, Abe T, Furuta Y, Shinmyo Y, Kaneko N, Hirota Y, Lupo G, Hatakeyama J, Abdulhaleem M FA, Anam MB, Yamaguchi M, Takeo T, Takebayashi H, Takebayashi M, Oike Y, Nakagata N, Shimamura K, Holtzman MJ, Takahashi Y, Guillemot F, Miyakawa T, Sawamoto K, Ohta K
Structural basis of malaria RIFIN binding by LILRB1-containing antibodies.
1. Nature - published March 3, 2021
2. Chen Y, Xu K, Piccoli L, Foglierini M, Tan J, Jin W, Gorman J, Tsybovsky Y, Zhang B, Traore B, Silacci-Fregni C, Daubenberger C, Crompton PD, Geiger R, Sallusto F, Kwong PD, Lanzavecchia A
Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism.
1. J Biol Chem - published March 3, 2021
2. Tao J, Berthet A, Citron YR, Tsiolaki PL, Stanley R, Gestwicki JE, Agard DA, McConlogue L
The renaissance in biophysics and molecular biology enabled by the interface of DNA repair and replication with cancer.
1. Prog Biophys Mol Biol - published March 3, 2021
2. Zhang X, Blundell T, Tainer JA
Effectiveness of mechanical cardiopulmonary resuscitation for patients with COVID-19 and in hospital cardiac arrest.
1. Resuscitation - published March 3, 2021
2. Bhardwaj A, Alwakeel M, Wang X, Duggal A, Gaieski DF, Fadel FA
Inhibitor Development against p7 Channel in Hepatitis C Virus.
1. Molecules - published March 3, 2021
2. Wei S, Hu X, Du L, Zhao L, Xue H, Liu C, Chou JJ, Zhong J, Tong Y, Wang S, OuYang B
Structural basis for the initiation of COPII vesicle biogenesis.
1. Structure - published March 3, 2021
2. Joiner AMN, Fromme JC
Ongoing Global and Regional Adaptive Evolution of SARS-CoV-2.
1. bioRxiv - published March 2, 2021
2. Rochman ND, Wolf YI, Faure G, Mutz P, Zhang F, Koonin EV
What Every Reader Should Know About Studies Using Electronic Health Record Data but May Be Afraid to Ask.
1. J Med Internet Res - published March 2, 2021
2. Kohane IS, Aronow BJ, Avillach P, Beaulieu-Jones BK, Bellazzi R, Bradford RL, Brat GA, Cannataro M, Cimino JJ, García-Barrio N, Gehlenborg N, Ghassemi M, Gutiérrez-Sacristán A, Hanauer DA, Holmes JH, Hong C, Klann JG, Loh NHW, Luo Y, Mandl KD, Daniar M, Moore JH, Murphy SN, Neuraz A, Ngiam KY, Omenn GS, Palmer N, Patel LP, Pedrera-Jiménez M, Sliz P, South AM, Tan ALM, Taylor DM, Taylor BW, Torti C, Vallejos AK, Wagholikar KB, Consortium For Clinical Characterization Of COVID-19 By EHR (4CE)., Weber GM, Cai T
AID overexpression leads to aggressive murine CLL and non-Ig mutations that mirror human neoplasms.
1. Blood - published March 2, 2021
2. Morande PE, Yan XJ, Sepulveda-Yanez JH, Seija N, Marquez ME, Sotelo NS, Abreu C, Crispo M, Fernández-Graña G, Rego N, Bois T, Methot SP, Palacios F, Remedi V, Rai KR, Buschiazzo A, Di Noia JM, Navarrete MA, Chiorazzi N, Oppezzo P
Contributions of the Four Essential Entry Glycoproteins to HSV-1 Tropism and the Selection of Entry Routes.
1. mBio - published March 2, 2021
2. Hilterbrand AT, Daly RE, Heldwein EE
Structure-function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting.
1. Nat Commun - published March 2, 2021
2. Du Z, Brown BP, Kim S, Ferguson D, Pavlick DC, Jayakumaran G, Benayed R, Gallant JN, Zhang YK, Yan Y, Red-Brewer M, Ali SM, Schrock AB, Zehir A, Ladanyi M, Smith AW, Meiler J, Lovly CM
Author Correction: Design of biologically active binary protein 2D materials.
1. Nature - published March 2, 2021
2. Ben-Sasson AJ, Watson JL, Sheffler W, Johnson MC, Bittleston A, Somasundaram L, Decarreau J, Jiao F, Chen J, Mela I, Drabek AA, Jarrett SM, Blacklow SC, Kaminski CF, Hura GL, De Yoreo JJ, Kollman JM, Ruohola-Baker H, Derivery E, Baker D
Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2.
1. Proc Natl Acad Sci U S A - published March 2, 2021
2. Liu Y, Hu G, Wang Y, Ren W, Zhao X, Ji F, Zhu Y, Feng F, Gong M, Ju X, Zhu Y, Cai X, Lan J, Guo J, Xie M, Dong L, Zhu Z, Na J, Wu J, Lan X, Xie Y, Wang X, Yuan Z, Zhang R, Ding Q
Novel RT-ddPCR assays for simultaneous quantification of multiple noncoding and coding regions of SARS-CoV-2 RNA.
1. J Virol Methods - published March 2, 2021
2. Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA
Direct Structural Insights into GABA_A Receptor Pharmacology.
1. Trends Biochem Sci - published March 2, 2021
2. Kim JJ, Hibbs RE
An in vitro reconstituted U1 snRNP allows the study of the disordered regions of the particle and the interactions with proteins and ligands.
1. Nucleic Acids Res - published March 2, 2021
2. Campagne S, de Vries T, Malard F, Afanasyev P, Dorn G, Dedic E, Kohlbrecher J, Boehringer D, Cléry A, Allain FH
Elusive Intermediate State Key in the Conversion of ATP Hydrolysis into Useful Work Driving the Ca²⁺ Pump SERCA.
1. J Phys Chem B - published March 2, 2021
2. Thirman J, Rui H, Roux B
Protein design-scapes generated by microfluidic DNA assembly elucidate domain coupling in the bacterial histidine kinase CpxA.
1. Proc Natl Acad Sci U S A - published March 2, 2021
2. Clark IC, Mensa B, Ochs CJ, Schmidt NW, Mravic M, Quintana FJ, DeGrado WF, Abate AR
Molecular assemblies of the catalytic domain of SOS with KRas and oncogenic mutants.
1. Proc Natl Acad Sci U S A - published March 2, 2021
2. Moghadamchargari Z, Shirzadeh M, Liu C, Schrecke S, Packianathan C, Russell DH, Zhao M, Laganowsky A
Targeting loss of heterozygosity for cancer-specific immunotherapy.
1. Proc Natl Acad Sci U S A - published March 2, 2021
2. Hwang MS, Mog BJ, Douglass J, Pearlman AH, Hsiue EH, Paul S, DiNapoli SR, Konig MF, Pardoll DM, Gabelli SB, Bettegowda C, Papadopoulos N, Vogelstein B, Zhou S, Kinzler KW
Oligomeric quaternary structure of Escherichia coli and Mycobacterium smegmatis Lhr helicases is nucleated by a novel C-terminal domain composed of five winged-helix modules.
1. Nucleic Acids Res - published March 2, 2021
2. Warren GM, Wang J, Patel DJ, Shuman S
Using culturomics and social media data to characterize wildlife consumption.
1. Conserv Biol - published March 2, 2021
2. Li J, Hu Q
Symptoms of Depression in Patients with Chemosensory Disorders.
1. ORL J Otorhinolaryngol Relat Spec - published March 2, 2021
2. Chen B, Benzien C, Faria V, Ning Y, Cuevas M, Linke J, Croy I, Haehner A, Hummel T
Discovery and resistance mechanism of a selective CDK12 degrader.
1. Nat Chem Biol - published March 2, 2021
2. Jiang B, Gao Y, Che J, Lu W, Kaltheuner IH, Dries R, Kalocsay M, Berberich MJ, Jiang J, You I, Kwiatkowski N, Riching KM, Daniels DL, Sorger PK, Geyer M, Zhang T, Gray NS
Time resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling.
1. Elife - published March 2, 2021
2. Vemulapalli V, Chylek LA, Erickson A, Pfeiffer A, Gabriel KH, LaRochelle J, Subramanian K, Cao R, Stegmaier K, Mohseni M, LaMarche MJ, Acker MG, Sorger PK, Gygi SP, Blacklow SC
Backbone chemical shift spectral assignments of SARS coronavirus-2 non-structural protein nsp9.
1. Biomol NMR Assign - published March 2, 2021
2. F Dudás E, Puglisi R, Korn SM, Alfano C, Bellone ML, Piaz FD, Kelly G, Monaca E, Schlundt A, Schwalbe H, Pastore A
Two-Dimensional Barriers for Probing Conformational Shifts in Macrocycles.
1. J Am Chem Soc - published March 2, 2021
2. Kobori S, Huh S, Appavoo SD, Yudin AK
Introduction: Drug Resistance.
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Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation.
1. Nat Commun - published March 2, 2021
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1. Protein Expr Purif - published March 1, 2021
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1. J Mol Graph Model - published March 1, 2021
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Potent Trivalent Inhibitors of Thrombin through Hybridization of Salivary Sulfopeptides from Hematophagous Arthropods.
1. Angew Chem Int Ed Engl - published March 1, 2021
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Carbapenem Use Is Driving the Evolution of Imipenemase 1 Variants.
1. Antimicrob Agents Chemother - published March 1, 2021
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Dynein regulates Kv7.4 channel trafficking from the cell membrane.
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1. STAR Protoc - published March 1, 2021
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Mechanisms of spacer acquisition by sequential assembly of the adaptation module in Synechocystis.
1. Nucleic Acids Res - published March 1, 2021
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The Matrix Revisited: Opening Night for the Pel Polysaccharide Across Eubacterial Kingdoms.
1. Microbiol Insights - published March 1, 2021
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Targeting a neoantigen derived from a common TP53 mutation.
1. Science - published March 1, 2021
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1. Sci Immunol - published March 1, 2021
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Targeting multiple enzymes in vitamin K metabolism for anticoagulation.
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Efficient purification and assembly of ribonucleoprotein complex for interaction analysis by MST assay coupled with GaMD simulations.
1. STAR Protoc - published March 1, 2021
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iMATCH: an integrated modular assembly system for therapeutic combination high-capacity adenovirus gene therapy.
1. Mol Ther Methods Clin Dev - published March 1, 2021
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Crystal structure of the nonclassical cadherin-17 N-terminus and implications for its adhesive binding mechanism.
1. Acta Crystallogr F Struct Biol Commun - published March 1, 2021
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A vulnerable, membrane-proximal site in human respiratory syncytial virus F revealed by a prefusion-specific single-domain antibody.
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Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design.
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1. J Virol - published March 1, 2021
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Cyclic Analogues of the Chemerin C-Terminus Mimic a Loop Conformation Essential for Activating the Chemokine-like Receptor 1.
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The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication.
1. Elife - published March 1, 2021
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REGALS: a general method to deconvolve X-ray scattering data from evolving mixtures.
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Development of single-stranded DNA bisintercalating inhibitors of primase DnaG as antibiotics.
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Protein Substrates Engage the Lumen of O-GlcNAc Transferase's Tetratricopeptide Repeat Domain in Different Ways.
1. Biochemistry - published March 1, 2021
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Rapid tilt-series method for cryo-electron tomography: Characterizing stage behavior during FISE acquisition.
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Crystal structure of P. falciparum Cpn60 bound to ATP reveals an open dynamic conformation before substrate binding.
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The Antifungal Drug Isavuconazole Inhibits the Replication of Human Cytomegalovirus (HCMV) and Acts Synergistically with Anti-HCMV Drugs.
1. Antiviral Res - published March 1, 2021
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SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19.
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Differential cellular responses to adhesive interactions with galectin-8 and fibronectin coated substrates.
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In vitro characterization of engineered red blood cells as viral traps against HIV-1 and SARS-CoV-2.
1. Mol Ther Methods Clin Dev - published March 1, 2021
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Structural impact on SARS-CoV-2 spike protein by D614G substitution.
1. Science - published March 1, 2021
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Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion.
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Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes.
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Surface proteomics reveals CD72 as a target for in vitro-evolved nanobody-based CAR-T cells in KMT2A/MLL1-rearranged B-ALL.
1. Cancer Discov - published March 1, 2021
2. Nix MA, Mandal K, Geng H, Paranjape N, Lin YT, Rivera J, Marcoulis M, White KL, Whitman JD, Bapat SP, Parker KR, Ramirez J, Deucher A, Phojanokong P, Steri V, Fattahi F, Hann B, Satpathy AT, Manglik A, Stieglitz E, Wiita AP
Prediction of amphipathic helix-Membrane interactions with Rosetta.
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A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection.
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DNA-driven condensation assembles the meiotic DNA break machinery.
1. Nature - published March 1, 2021
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1. Cell - published March 1, 2021
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A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies.
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Phenotypic approaches to small-molecule discovery in chemical biology.
1. Cell Chem Biol - published March 1, 2021
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Facile Synthesis of a Croconaine-Based Nanoformulation for Optoacoustic Imaging and Photothermal Therapy.
1. Adv Healthc Mater - published March 1, 2021
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Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10.
1. Science - published March 1, 2021
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A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes.
1. Nat Commun - published March 1, 2021
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The groovy TMEM16 family: molecular mechanisms of lipid scrambling and ion conduction.
1. J Mol Biol - published March 1, 2021
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Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.
1. Cell - published March 1, 2021
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Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium.
1. Commun Biol - published March 1, 2021
2. Gandhi AK, Sun ZJ, Kim WM, Huang YH, Kondo Y, Bonsor DA, Sundberg EJ, Wagner G, Kuchroo VK, Petsko GA, Blumberg RS
Highlighting membrane protein structure and function: A celebration of the Protein Data Bank.
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Integrating 3D structural information into systems biology.
1. J Biol Chem - published March 1, 2021
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Free-Radical Membrane Protein Footprinting by Photolysis of Perfluoroisopropyl Iodide Partitioned to Detergent Micelle by Sonication.
1. Angew Chem Int Ed Engl - published March 1, 2021
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A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques.
1. Cell Rep Med - published March 1, 2021
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Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies.
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Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry.
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Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein.
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Odontoblast TRPC5 channels signal cold pain in teeth.
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A cryo-electron tomography workflow reveals protrusion-mediated shedding on injured plasma membrane.
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Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase.
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Design of Alphavirus Virus-Like Particles Presenting Circumsporozoite Junctional Epitopes That Elicit Protection against Malaria.
1. Vaccines (Basel) - published March 1, 2021
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A Crisis-Responsive Framework for Medical Device Development Applied to the COVID-19 Pandemic.
1. Front Digit Health - published March 1, 2021
2. Antonini MJ, Plana D, Srinivasan S, Atta L, Achanta A, Yang H, Cramer AK, Freake J, Sinha MS, Yu SH, LeBoeuf NR, Linville-Engler B, Sorger PK
A PyMOL snippet library for Jupyter to boost researcher productivity.
1. Comput Sci Eng - published March 1, 2021
2. Mooers BHM
Acyl metalloids: conformity and deviation from carbonyl reactivity.
1. Chem Sci - published March 1, 2021
2. Holownia A, Apte CN, Yudin AK