Member Publications

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117 Member Publications for May 2018

High-Throughput Screening Assay Datasets from the PubChem Database.
1. Chem Inform - published May 26, 2018
2. Butkiewicz M, Wang Y, Bryant SH, Lowe EW Jr, Weaver DC, Meiler J
An atypical BAR domain protein in autophagy.
1. Autophagy - published May 26, 2018
2. Popelka H, Klionsky DJ, Ragusa MJ
PKS-NRPS Enzymology and Structural Biology: Considerations in Protein Production.
1. Methods Enzymol - published May 22, 2018
2. Skiba MA, Maloney FP, Dan Q, Fraley AE, Aldrich CC, Smith JL, Brown WC
Chemoenzymatic Dissection of Polyketide β-Branching in the Bryostatin Pathway.
1. Methods Enzymol - published May 22, 2018
2. Slocum ST, Lowell AN, Tripathi A, Shende VV, Smith JL, Sherman DH
Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses.
1. Nat Commun - published May 14, 2018
2. Clark LE, Mahmutovic S, Raymond DD, Dilanyan T, Koma T, Manning JT, Shankar S, Levis SC, Briggiler AM, Enria DA, Wucherpfennig KW, Paessler S, Abraham J
Robust Production, Crystallization, Structure Determination, and Analysis of [Fe-S] Proteins: Uncovering Control of Electron Shuttling and Gating in the Respiratory Metabolism of Molybdopterin Guanine Dinucleotide Enzymes.
1. Methods Enzymol - published May 11, 2018
2. Tsai CL, Tainer JA
Characterization of a nontypeable Haemophilus influenzae thermonuclease.
1. PLoS One - published May 11, 2018
2. Cho C, Chande AT, Gakhar L, Hunt J, Ketterer MR, Apicella MA
Complete genome sequence and the expression pattern of plasmids of the model ethanologen Zymomonas mobilis ZM4 and its xylose-utilizing derivatives 8b and 2032.
1. Biotechnol Biofuels - published May 11, 2018
2. Yang S, Vera JM, Grass J, Savvakis G, Moskvin OV, Yang Y, McIlwain SJ, Lyu Y, Zinonos I, Hebert AS, Coon JJ, Bates DM, Sato TK, Brown SD, Himmel ME, Zhang M, Landick R, Pappas KM, Zhang Y
A Defined and Flexible Pocket Explains Aryl Substrate Promiscuity by the Cahuitamycin Starter Unit Activating Enzyme CahJ.
1. Chembiochem - published May 9, 2018
2. Sherman DH, Tripathi A, Park SR, Sikkema A, Cho HJ, Wu J, Lee B, Xi C, Smith JL
GADD45α sensitizes cervical cancer cells to radiotherapy via increasing cytoplasmic APE1 level.
1. Cell Death Dis - published May 9, 2018
2. Li Q, Wei X, Zhou ZW, Wang SN, Jin H, Chen KJ, Luo J, Westover KD, Wang JM, Wang D, Xu CX, Shan JL
Orsay δ protein is required for non-lytic viral egress.
1. J Virol - published May 9, 2018
2. Yuan W, Zhou Y, Fan Y, Tao YJ, Zhong W
A Novel Mechanism for Calmodulin-Dependent Inactivation of Transient Receptor Potential Vanilloid 6.
1. Biochemistry - published May 8, 2018
2. Bate N, Caves RE, Skinner SP, Goult BT, Basran J, Mitcheson JS, Vuister GW
Hydration Structure and Dynamics of Inhibitor-Bound HIV-1 Protease.
1. J Chem Theory Comput - published May 8, 2018
2. Leidner F, Kurt Yilmaz N, Paulsen J, Muller YA, Schiffer CA
The Structural Basis of Calcium-Dependent Inactivation of the Transient Receptor Potential Vanilloid 5 Channel.
1. Biochemistry - published May 8, 2018
2. Bokhovchuk FM, Bate N, Kovalevskaya NV, Goult BT, Spronk CAEM, Vuister GW
Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module.
1. ACS Chem Biol - published May 8, 2018
2. Skiba MA, Sikkema AP, Moss NA, Lowell AN, Su M, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL
CD147 Promotes Entry of Pentamer-Expressing Human Cytomegalovirus into Epithelial and Endothelial Cells.
1. mBio - published May 8, 2018
2. Vanarsdall AL, Pritchard SR, Wisner TW, Liu J, Jardetzky TS, Johnson DC
Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
1. Nat Commun - published May 8, 2018
2. Koliopoulos MG, Lethier M, van der Veen AG, Haubrich K, Hennig J, Kowalinski E, Stevens RV, Martin SR, Reis E Sousa C, Cusack S, Rittinger K
Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer.
1. Mol Pharmacol - published May 8, 2018
2. Maximov PY, Abderrahman B, Fanning SW, Sengupta S, Fan P, Curpan RF, Quintana Rincon DM, Greenland JA, Rajan SS, Greene GL, Jordan VC
Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior.
1. Cell Rep - published May 8, 2018
2. Brasch J, Katsamba PS, Harrison OJ, Ahlsén G, Troyanovsky RB, Indra I, Kaczynska A, Kaeser B, Troyanovsky S, Honig B, Shapiro L
Profilin 1-mediated cytoskeletal rearrangements regulate integrin function in mouse platelets.
1. Blood Adv - published May 8, 2018
2. Stritt S, Birkholz I, Beck S, Sorrentino S, Sapra KT, Viaud J, Heck J, Gaits-Iacovoni F, Schulze H, Du X, Hartwig JH, Braun A, Bender M, Medalia O, Nieswandt B
Evolutionary conservation of the allosteric activation of factor VIIa by tissue factor in lamprey: reply.
1. J Thromb Haemost - published May 7, 2018
2. Beeler DL, Aird WC, Grant MA
Targocil-exposure of Staphylococcus aureus Blocks Translocation of the Major Autolysin Atl Across the Membrane Resulting in a Significant Decrease in Autolysis.
1. Antimicrob Agents Chemother - published May 7, 2018
2. Tiwari KB, Gatto C, Walker S, Wilkinson BJ
Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1 (Cas12a).
1. Proc Natl Acad Sci U S A - published May 7, 2018
2. Singh D, Mallon J, Poddar A, Wang Y, Tippana R, Yang O, Bailey S, Ha T
Discovery of proteins associated with a predefined genomic locus via dCas9-APEX-mediated proximity labeling.
1. Nat Methods - published May 7, 2018
2. Myers SA, Wright J, Peckner R, Kalish BT, Zhang F, Carr SA
Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L.
1. Front Mol Biosci - published May 5, 2018
2. Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF
Capture of Pb²⁺ and Cu²⁺ Metal Cations by Neisseria meningitidis-type Capsular Polysaccharides.
1. Biomolecules - published May 5, 2018
2. Ghimire S, McCarthy PC
Heterologous Expression and Purification of CRISPR-Cas12a/Cpf1.
1. Bio Protoc - published May 5, 2018
2. Mohanraju P, Van Der Oost J, Jinek M, Swarts DC
Design of a Short Thermally Stable α-Helix Embedded in a Macrocycle.
1. Chembiochem - published May 4, 2018
2. Wu H, Acharyya A, Wu Y, Liu L, Jo H, Gai F, DeGrado WF
Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.
1. Science - published May 4, 2018
2. Lee CH, MacKinnon R
Structure of the DASH/Dam1 complex shows its role at the yeast kinetochore-microtubule interface.
1. Science - published May 4, 2018
2. Jenni S, Harrison SC
A "cross-stitched" peptide with improved helicity and proteolytic stability.
1. Org Biomol Chem - published May 4, 2018
2. Speltz TE, Mayne CG, Fanning SW, Siddiqui Z, Tajkhorshid E, Greene GL, Moore TW
An Escherichia coli nitrogen starvation response is important for mutualistic coexistence with Rhodopseudomonas palustris.
1. Appl Environ Microbiol - published May 4, 2018
2. McCully AL, Behringer MG, Gliessman JR, Pilipenko EV, Mazny JL, Lynch M, Drummond DA, McKinlay JB
Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A.
1. Nucleic Acids Res - published May 4, 2018
2. Fislage M, Zhang J, Brown ZP, Mandava CS, Sanyal S, Ehrenberg M, Frank J
Convergent Use of Heptacoordination for Cation Selectivity by RNA and Protein Metalloregulators.
1. Cell Chem Biol - published May 4, 2018
2. Bachas ST, Ferré-D'Amaré AR
The BUB3-BUB1 Complex Promotes Telomere DNA Replication.
1. Mol Cell - published May 3, 2018
2. Li F, Kim H, Ji Z, Zhang T, Chen B, Ge Y, Hu Y, Feng X, Han X, Xu H, Zhang Y, Yu H, Liu D, Ma W, Songyang Z
Gut microbiota utilize immunoglobulin A for mucosal colonization.
1. Science - published May 3, 2018
2. Donaldson GP, Ladinsky MS, Yu KB, Sanders JG, Yoo BB, Chou WC, Conner ME, Earl AM, Knight R, Bjorkman PJ, Mazmanian SK
Microsecond motions probed by near-rotary-resonance R1ρ15N MAS NMR experiments: the model case of protein overall-rocking in crystals.
1. J Biomol NMR - published May 3, 2018
2. Krushelnitsky A, Gauto D, Rodriguez Camargo DC, Schanda P, Saalwächter K
Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells.
1. Nature - published May 3, 2018
2. Fraietta JA, Nobles CL, Sammons MA, Lundh S, Carty SA, Reich TJ, Cogdill AP, Morrissette JJD, DeNizio JE, Reddy S, Hwang Y, Gohil M, Kulikovskaya I, Nazimuddin F, Gupta M, Chen F, Everett JK, Alexander KA, Lin-Shiao E, Gee MH, Liu X, Young RM, Ambrose D, Wang Y, Xu J, Jordan MS, Marcucci KT, Levine BL, Garcia KC, Zhao Y, Kalos M, Porter DL, Kohli RM, Lacey SF, Berger SL, Bushman FD, June CH, Melenhorst JJ
Establishment of Striacosta albicosta (Lepidoptera: Noctuidae) as a Primary Pest of Corn in the Great Lakes Region.
1. J Econ Entomol - published May 3, 2018
2. Smith JL, Baute TS, Sebright MM, Schaafsma AW, DiFonzo CD
Author Correction: Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.
1. Nat Commun - published May 3, 2018
2. Schulze WM, Stein F, Rettel M, Nanao M, Cusack S
Structural Basis for Transcript Elongation Control by NusG Family Universal Regulators.
1. Cell - published May 3, 2018
2. Kang JY, Mooney RA, Nedialkov Y, Saba J, Mishanina TV, Artsimovitch I, Landick R, Darst SA
Structural Basis for G Protein-Coupled Receptor Signaling.
1. Annu Rev Biophys - published May 2, 2018
2. Erlandson SC, McMahon C, Kruse AC
Modular Synthesis of β-Amino Boronate Peptidomimetics.
1. J Org Chem - published May 2, 2018
2. Kaldas SJ, Rogova T, Nenajdenko VG, Yudin AK
Holistic Approach to Partial Covalent Interactions in Protein Structure Prediction and Design with Rosetta.
1. J Chem Inf Model - published May 2, 2018
2. Combs SA, Mueller BK, Meiler J
Luciferase Advisor: High-Accuracy Model To Flag False Positive Hits in Luciferase HTS Assays.
1. J Chem Inf Model - published May 2, 2018
2. Ghosh D, Koch U, Hadian K, Sattler M, Tetko IV
ICBS 2017 in Shanghai-Illuminating Life with Chemical Innovation.
1. ACS Chem Biol - published May 2, 2018
2. Zhang Q, Zhang J, Gavathiotis E
Pepluanols C-D, Two Diterpenoids with Two Skeletons from Euphorbia peplus.
1. Org Lett - published May 2, 2018
2. Wan LS, Nian Y, Peng XR, Shao LD, Li XN, Yang J, Zhou M, Qiu MH
THE AER2 RECEPTOR FROM VIBRIO CHOLERAE IS A DUAL PAS-HEME OXYGEN SENSOR.
1. Mol Microbiol - published May 2, 2018
2. Greer-Phillips SE, Sukomon N, Chua TK, Johnson MS, Crane BR, Watts KJ
A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer.
1. Biochemistry - published May 2, 2018
2. Finer-Moore JS, Lee TT, Stroud RM
Development of a stress response therapy targeting aggressive prostate cancer.
1. Sci Transl Med - published May 2, 2018
2. Nguyen HG, Conn CS, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, Carroll PR, Ruggero D
Structural principles of distinct assemblies of the human α4β2 nicotinic receptor.
1. Nature - published May 2, 2018
2. Walsh RM Jr, Roh SH, Gharpure A, Morales-Perez CL, Teng J, Hibbs RE
Nanoparticle Wettability Influences Nanoparticle-Phospholipid Interactions.
1. Langmuir - published May 2, 2018
2. Konduru NV, Damiani F, Stoilova-McPhie S, Tresback JS, Pyrgiotakis G, Donaghey TC, Demokritou P, Brain JD, Molina RM
Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility.
1. Proc Natl Acad Sci U S A - published May 2, 2018
2. Li W, Hulswit RJG, Kenney SP, Widjaja I, Jung K, Alhamo MA, van Dieren B, van Kuppeveld FJM, Saif LJ, Bosch BJ
Crystal Structures of the Mango-II RNA Aptamer Reveal Heterogeneous Fluorophore Binding and Guide Engineering of Variants with Improved Selectivity and Brightness.
1. Biochemistry - published May 2, 2018
2. Trachman RJ 3rd, Abdolahzadeh A, Andreoni A, Cojocaru R, Knutson JR, Ryckelynck M, Unrau PJ, Ferré-D'Amaré AR
Structure of an EIIC sugar transporter trapped in an inward-facing conformation.
1. Proc Natl Acad Sci U S A - published May 2, 2018
2. Ren Z, Lee J, Moosa MM, Nian Y, Hu L, Xu Z, McCoy JG, Ferreon ACM, Im W, Zhou M
Dissection of DNA double-strand-break repair using novel single-molecule forceps.
1. Nat Struct Mol Biol - published May 2, 2018
2. Wang JL, Duboc C, Wu Q, Ochi T, Liang S, Tsutakawa SE, Lees-Miller SP, Nadal M, Tainer JA, Blundell TL, Strick TR
Cas9 versus Cas12a/Cpf1: Structure-function comparisons and implications for genome editing.
1. Wiley Interdiscip Rev RNA - published May 2, 2018
2. Swarts DC, Jinek M
rbFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences.
1. Nat Commun - published May 2, 2018
2. Sellier C, Cerro-Herreros E, Blatter M, Freyermuth F, Gaucherot A, Ruffenach F, Sarkar P, Puymirat J, Udd B, Day JW, Meola G, Bassez G, Fujimura H, Takahashi MP, Schoser B, Furling D, Artero R, Allain FHT, Llamusi B, Charlet-Berguerand N
Synthetic single domain antibodies for the conformational trapping of membrane proteins.
1. Elife - published May 2, 2018
2. Zimmermann I, Egloff P, Hutter CA, Arnold FM, Stohler P, Bocquet N, Hug MN, Huber S, Siegrist M, Hetemann L, Gera J, Gmür S, Spies P, Gygax D, Geertsma ER, Dawson RJ, Seeger MA
Molecular Mechanisms of Fast Neurotransmitter Release.
1. Annu Rev Biophys - published May 2, 2018
2. Brunger AT, Choi UB, Lai Y, Leitz J, Zhou Q
Are we there yet? How and when specific biotechnologies will improve human health.
1. Biotechnol J - published May 2, 2018
2. O'Day E, Hosta-Rigau L, Oyarzún DA, Okano H, de Lorenzo V, von Kameke C, Alsafar H, Cao C, Chen GQ, Ji W, Roberts RJ, Ronaghi M, Yeung K, Zhang F, Lee SY
Structure of the CLC-1 chloride channel from Homo sapiens.
1. Elife - published May 2, 2018
2. Park E, MacKinnon R
Functional and structural characterization of an ECF-type ABC transporter for vitamin B12.
1. Elife - published May 2, 2018
2. Santos JA, Rempel S, Mous ST, Pereira CT, Ter Beek J, de Gier JW, Guskov A, Slotboom DJ
Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair.
1. Elife - published May 2, 2018
2. Savic N, Ringnalda FC, Lindsay H, Berk C, Bargsten K, Li Y, Neri D, Robinson MD, Ciaudo C, Hall J, Jinek M, Schwank G
Routine single particle CryoEM sample and grid characterization by tomography.
1. Elife - published May 2, 2018
2. Noble AJ, Dandey VP, Wei H, Brasch J, Chase J, Acharya P, Tan YZ, Zhang Z, Kim LY, Scapin G, Rapp M, Eng ET, Rice WJ, Cheng A, Negro CJ, Shapiro L, Kwong PD, Jeruzalmi D, des Georges A, Potter CS, Carragher B
The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins.
1. Elife - published May 2, 2018
2. Shurtleff MJ, Itzhak DN, Hussmann JA, Schirle Oakdale NT, Costa EA, Jonikas M, Weibezahn J, Popova KD, Jan CH, Sinitcyn P, Vembar SS, Hernandez H, Cox J, Burlingame AL, Brodsky J, Frost A, Borner GH, Weissman JS
Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange.
1. Cell Rep - published May 2, 2018
2. Johnson B, McConnell P, Kozlov AG, Mekel M, Lohman TM, Gross ML, Amarasinghe GK, Cooper JA
Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery.
1. Circulation - published May 2, 2018
2. Wisler JW, Rockman HA, Lefkowitz RJ
A Comprehensive Mutagenesis Screen of the Adhesion GPCR Latrophilin-1/ADGRL1.
1. iScience - published May 2, 2018
2. Nazarko O, Kibrom A, Winkler J, Leon K, Stoveken H, Salzman G, Merdas K, Lu Y, Narkhede P, Tall G, Prömel S, Araç D
HDAC1 Governs Iron Homeostasis Independent of Histone Deacetylation in Iron-Overload Murine Models.
1. Antioxid Redox Signal - published May 1, 2018
2. Yin X, Wu Q, Monga J, Xie E, Wang H, Wang S, Zhang H, Wang ZY, Zhou T, Shi Y, Rogers J, Lin H, Min J, Wang F
Mu transpososome activity-profiling yields hyperactive MuA variants for highly efficient genetic and genome engineering.
1. Nucleic Acids Res - published May 1, 2018
2. Rasila TS, Pulkkinen E, Kiljunen S, Haapa-Paananen S, Pajunen MI, Salminen A, Paulin L, Vihinen M, Rice PA, Savilahti H
Functional evaluation of tryptophans in glycolipid binding and membrane interaction by HET-C2, a fungal glycolipid transfer protein.
1. Biochim Biophys Acta Biomembr - published May 1, 2018
2. Kenoth R, Zou X, Simanshu DK, Pike HM, Malinina L, Patel DJ, Brown RE, Kamlekar RK
Global versus local mechanisms of temperature sensing in ion channels.
1. Pflugers Arch - published May 1, 2018
2. Arrigoni C, Minor DL Jr
Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens.
1. ACS Infect Dis - published May 1, 2018
2. Georgiev IS, Joyce MG, Chen RE, Leung K, McKee K, Druz A, Van Galen JG, Kanekiyo M, Tsybovsky Y, Yang ES, Yang Y, Acharya P, Pancera M, Thomas PV, Wanninger T, Yassine HM, Baxa U, Doria-Rose NA, Cheng C, Graham BS, Mascola JR, Kwong PD
Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.
1. ACS Infect Dis - published May 1, 2018
2. Negri A, Javidnia P, Mu R, Zhang X, Vendome J, Gold B, Roberts J, Barman D, Ioerger T, Sacchettini JC, Jiang X, Burns-Huang K, Warrier T, Ling Y, Warren JD, Oren DA, Beuming T, Wang H, Wu J, Li H, Rhee KY, Nathan CF, Liu G, Somersan-Karakaya S
Electron cryotomography of Mycoplasma pneumoniae mutants correlates terminal organelle architectural features and function.
1. Mol Microbiol - published May 1, 2018
2. Krause DC, Chen S, Shi J, Jensen AJ, Sheppard ES, Jensen GJ
Phosphorylation control of the ubiquitin ligase Cbl is conserved in choanoflagellates.
1. Protein Sci - published May 1, 2018
2. Amacher JF, Hobbs HT, Cantor AC, Shah L, Rivero MJ, Mulchand SA, Kuriyan J
Involvement in surface antigen expression by a moonlighting FG-repeat nucleoporin in trypanosomes.
1. Mol Biol Cell - published May 1, 2018
2. Holden JM, Koreny L, Obado S, Ratushny AV, Chen WM, Bart JM, Navarro M, Chait BT, Aitchison JD, Rout MP, Field MC
Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape.
1. J Virol - published May 1, 2018
2. Wang L, Shi W, Chappell JD, Joyce MG, Zhang Y, Kanekiyo M, Becker MM, van Doremalen N, Fischer R, Wang N, Corbett KS, Choe M, Mason RD, Van Galen JG, Zhou T, Saunders KO, Tatti KM, Haynes LM, Kwong PD, Modjarrad K, Kong WP, McLellan JS, Denison MR, Munster VJ, Mascola JR, Graham BS
Determinants of Raft Partitioning of the Helicobacter pylori Pore-Forming Toxin VacA.
1. Infect Immun - published May 1, 2018
2. Raghunathan K, Foegeding NJ, Campbell AM, Cover TL, Ohi MD, Kenworthy AK
A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.
1. Nat Med - published May 1, 2018
2. Kisalu NK, Idris AH, Weidle C, Flores-Garcia Y, Flynn BJ, Sack BK, Murphy S, Schön A, Freire E, Francica JR, Miller AB, Gregory J, March S, Liao HX, Haynes BF, Wiehe K, Trama AM, Saunders KO, Gladden MA, Monroe A, Bonsignori M, Kanekiyo M, Wheatley AK, McDermott AB, Farney SK, Chuang GY, Zhang B, Kc N, Chakravarty S, Kwong PD, Sinnis P, Bhatia SN, Kappe SHI, Sim BKL, Hoffman SL, Zavala F, Pancera M, Seder RA
JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling.
1. J Clin Invest - published May 1, 2018
2. Zhang Y, Xia F, Liu X, Yu Z, Xie L, Liu L, Chen C, Jiang H, Hao X, He X, Zhang F, Gu H, Zhu J, Bai H, Zhang CC, Chen GQ, Zheng J
The unassembled flavoprotein subunits of human and bacterial complex II have impaired catalytic activity and generate only minor amounts of ROS.
1. J Biol Chem - published May 1, 2018
2. Maklashina E, Rajagukguk S, Iverson TM, Cecchini G
In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors.
1. Genome Res - published May 1, 2018
2. Sutandy FXR, Ebersberger S, Huang L, Busch A, Bach M, Kang HS, Fallmann J, Maticzka D, Backofen R, Stadler PF, Zarnack K, Sattler M, Legewie S, König J
High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane.
1. Science - published May 1, 2018
2. Srivastava AP, Luo M, Zhou W, Symersky J, Bai D, Chambers MG, Faraldo-Gómez JD, Liao M, Mueller DM
Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments.
1. Nat Protoc - published May 1, 2018
2. Canver MC, Haeussler M, Bauer DE, Orkin SH, Sanjana NE, Shalem O, Yuan GC, Zhang F, Concordet JP, Pinello L
Investigating isoindoline, tetrahydroisoquinoline, and tetrahydrobenzazepine scaffolds for their sigma receptor binding properties.
1. Eur J Med Chem - published May 1, 2018
2. Linkens K, Schmidt HR, Sahn JJ, Kruse AC, Martin SF
Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing.
1. J Am Chem Soc - published May 1, 2018
2. Rouet R, Thuma BA, Roy MD, Lintner NG, Rubitski DM, Finley JE, Wisniewska HM, Mendonsa R, Hirsh A, de Oñate L, Compte Barrón J, McLellan TJ, Bellenger J, Feng X, Varghese A, Chrunyk BA, Borzilleri K, Hesp KD, Zhou K, Ma N, Tu M, Dullea R, McClure KF, Wilson RC, Liras S, Mascitti V, Doudna JA
Inactivated influenza vaccine stress can affect in vitro potency assay relationship to immunogenicity.
1. Vaccine - published May 1, 2018
2. Wen Y, Palladino G, Xie Y, Ferrari A, Settembre EC
Cryo-EM structure of substrate-bound human telomerase holoenzyme.
1. Nature - published May 1, 2018
2. Nguyen THD, Tam J, Wu RA, Greber BJ, Toso D, Nogales E, Collins K
PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21.
1. Cell Rep - published May 1, 2018
2. Liu X, Zhang F, Zhang Y, Li X, Chen C, Zhou M, Yu Z, Liu Y, Zhao Y, Hao X, Tang Y, Zhu L, Liu L, Xie L, Gu H, Shao H, Xia F, Yin C, Tao M, Xie J, Zhang CC, Yang Y, Sun H, Chen GQ, Zheng J
Determination of Patterson group symmetry from sparse multi-crystal data sets in the presence of an indexing ambiguity.
1. Acta Crystallogr D Struct Biol - published May 1, 2018
2. Gildea RJ, Winter G
Architecture of the U6 snRNP reveals specific recognition of 3'-end processed U6 snRNA.
1. Nat Commun - published May 1, 2018
2. Montemayor EJ, Didychuk AL, Yake AD, Sidhu GK, Brow DA, Butcher SE
Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site.
1. Nat Commun - published May 1, 2018
2. Wahlgren WY, Dunevall E, North RA, Paz A, Scalise M, Bisignano P, Bengtsson-Palme J, Goyal P, Claesson E, Caing-Carlsson R, Andersson R, Beis K, Nilsson UJ, Farewell A, Pochini L, Indiveri C, Grabe M, Dobson RCJ, Abramson J, Ramaswamy S, Friemann R
Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase.
1. J Med Chem - published May 1, 2018
2. Madak JT, Cuthbertson CR, Miyata Y, Tamura S, Petrunak EM, Stuckey JA, Han Y, He M, Sun D, Showalter HD, Neamati N
Structural basis for membrane anchoring and fusion regulation of the herpes simplex virus fusogen gB.
1. Nat Struct Mol Biol - published May 1, 2018
2. Cooper RS, Georgieva ER, Borbat PP, Freed JH, Heldwein EE
Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation.
1. Elife - published May 1, 2018
2. Zhang Z, Tóth B, Szollosi A, Chen J, Csanády L
Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons.
1. ACS Infect Dis - published May 1, 2018
2. Gibson EG, Blower TR, Cacho M, Bax B, Berger JM, Osheroff N
Structural Basis for Disassembly of Katanin Heterododecamers.
1. J Biol Chem - published May 1, 2018
2. Nithianantham S, McNally FJ, Al-Bassam J
Targeting Therapy Resistance: When Glutamine Catabolism Becomes Essential.
1. Cancer Cell - published May 1, 2018
2. Lukey MJ, Katt WP, Cerione RA
Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions.
1. Sci Rep - published May 1, 2018
2. Silvas TV, Hou S, Myint W, Nalivaika E, Somasundaran M, Kelch BA, Matsuo H, Kurt Yilmaz N, Schiffer CA
The Mycobacterium tuberculosis Complex has a Pathway for the Biosynthesis of 4-Formamido-4,6-Dideoxy-d-Glucose.
1. Protein Sci - published May 1, 2018
2. Brown HA, Vinogradov E, Gilbert M, Holden HM
Tick-Borne Encephalitis Virus Nonstructural Protein NS5 Induces RANTES Expression Dependent on the RNA-Dependent RNA Polymerase Activity.
1. J Immunol - published May 1, 2018
2. Zheng Z, Yang J, Jiang X, Liu Y, Zhang X, Li M, Zhang M, Fu M, Hu K, Wang H, Luo MH, Gong P, Hu Q
Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module.
1. J Am Chem Soc - published May 1, 2018
2. Li X, Sevillano N, La Greca F, Deis L, Liu YC, Deller MC, Mathews II, Matsui T, Cane DE, Craik CS, Khosla C
HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure.
1. Immunity - published May 1, 2018
2. Kwong PD, Mascola JR
Peek-Peak-Pique: Repeating Motifs of Subtle Variance Are Targets for Potent Malaria Antibodies.
1. Immunity - published May 1, 2018
2. Scally SW, Julien JP
Structure of a volume-regulated anion channel of the LRRC8 family.
1. Nature - published May 1, 2018
2. Deneka D, Sawicka M, Lam AKM, Paulino C, Dutzler R
Structural basis for gating pore current in periodic paralysis.
1. Nature - published May 1, 2018
2. Jiang D, Gamal El-Din TM, Ing C, Lu P, Pomès R, Zheng N, Catterall WA
Mxra8 is a receptor for multiple arthritogenic alphaviruses.
1. Nature - published May 1, 2018
2. Zhang R, Kim AS, Fox JM, Nair S, Basore K, Klimstra WB, Rimkunas R, Fong RH, Lin H, Poddar S, Crowe JE Jr, Doranz BJ, Fremont DH, Diamond MS
Structural Analysis of Small Molecule Binding to the BAZ2A and BAZ2B Bromodomains.
1. ChemMedChem - published May 1, 2018
2. Dalle Vedove A, Spiliotopoulos D, D'Agostino VG, Marchand JR, Unzue A, Nevado C, Lolli G, Caflisch A
X-ray structure of a carpet-like antimicrobial defensin-phospholipid membrane disruption complex.
1. Nat Commun - published May 1, 2018
2. Järvå M, Lay FT, Phan TK, Humble C, Poon IKH, Bleackley MR, Anderson MA, Hulett MD, Kvansakul M
C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases.
1. Mol Cell - published May 1, 2018
2. Lin HC, Yeh CW, Chen YF, Lee TT, Hsieh PY, Rusnac DV, Lin SY, Elledge SJ, Zheng N, Yen HS
Zebrafish VCAP1X2 regulates cardiac contractility and proliferation of cardiomyocytes and epicardial cells.
1. Sci Rep - published May 1, 2018
2. Hsieh FC, Lu YF, Liau I, Chen CC, Cheng CM, Hsiao CD, Hwang SL
Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.
1. PLoS Biol - published May 1, 2018
2. Stöppler D, Macpherson A, Smith-Penzel S, Basse N, Lecomte F, Deboves H, Taylor RD, Norman T, Porter J, Waters LC, Westwood M, Cossins B, Cain K, White J, Griffin R, Prosser C, Kelm S, Sullivan AH, Fox D 3rd, Carr MD, Henry A, Taylor R, Meier BH, Oschkinat H, Lawson AD
Mis16 Switches Function from a Histone H4 Chaperone to a CENP-ACnp1-Specific Assembly Factor through Eic1 Interaction.
1. Structure - published May 1, 2018
2. An S, Koldewey P, Chik J, Subramanian L, Cho US
De novo designed transmembrane peptides activating the α5β1 integrin.
1. Protein Eng Des Sel - published May 1, 2018
2. Mravic M, Hu H, Lu Z, Bennett JS, Sanders CR, Orr AW, DeGrado WF
Targeting protein and peptide therapeutics to the heart via tannic acid modification.
1. Nat Biomed Eng - published May 1, 2018
2. Shin M, Lee HA, Lee M, Shin Y, Song JJ, Kang SW, Nam DH, Jeon EJ, Cho M, Do M, Park S, Lee MS, Jang JH, Cho SW, Kim KS, Lee H