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105 Member Publications for April 2018

In silico and crystallographic studies identify key structural features of biliverdin IXβ reductase inhibitors having nanomolar potency.
1. J Biol Chem - published April 13, 2018
2. Nesbitt NM, Zheng X, Li Z, Manso JA, Yen WY, Malone LE, Ripoll-Rozada J, Pereira PJB, Mantle TJ, Wang J, Bahou WF
Ordering Protein Contact Matrices.
1. Comput Struct Biotechnol J - published April 11, 2018
2. Xu C, Bouvier G, Bardiaux B, Nilges M, Malliavin T, Lisser A
Genomes in Focus: Development and Applications of CRISPR-Cas9 Imaging Technologies.
1. Angew Chem Int Ed Engl - published April 9, 2018
2. Knight SC, Tjian R, Doudna JA
Targeting IS608 transposon integration to highly specific sequences by structure-based transposon engineering.
1. Nucleic Acids Res - published April 9, 2018
2. Morero NR, Zuliani C, Kumar B, Bebel A, Okamoto S, Guynet C, Hickman AB, Chandler M, Dyda F, Barabas O
Development of a Prototype System for Archiving Integrative/Hybrid Structure Models of Biological Macromolecules.
1. Structure - published April 9, 2018
2. Vallat B, Webb B, Westbrook JD, Sali A, Berman HM
Unraveling the sequence of cytosolic reactions in the export of GspB adhesin from Streptococcus gordonii.
1. J Biol Chem - published April 6, 2018
2. Chen Y, Bensing BA, Seepersaud R, Mi W, Liao M, Jeffrey PD, Shajahan A, Sonon RN, Azadi P, Sullam PM, Rapoport TA
Up close with herpesviruses.
1. Science - published April 6, 2018
2. Heldwein EE
Modular assembly of the nucleolar pre-60S ribosomal subunit.
1. Nature - published April 5, 2018
2. Sanghai ZA, Miller L, Molloy KR, Barandun J, Hunziker M, Chaker-Margot M, Wang J, Chait BT, Klinge S
Regulation and function of H3K36 di-methylation by the trithorax-group protein complex AMC.
1. Development - published April 5, 2018
2. Schmähling S, Meiler A, Lee Y, Mohammed A, Finkl K, Tauscher K, Israel L, Wirth M, Philippou-Massier J, Blum H, Habermann B, Imhof A, Song JJ, Müller J
Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel.
1. Nature - published April 5, 2018
2. She J, Guo J, Chen Q, Zeng W, Jiang Y, Bai XC
Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids.
1. J Am Chem Soc - published April 4, 2018
2. Gebregiworgis T, Marshall CB, Nishikawa T, Radulovich N, Sandí MJ, Fang Z, Rottapel R, Tsao MS, Ikura M
Shell feature: a new radiomics descriptor for predicting distant failure after radiotherapy in non-small cell lung cancer and cervix cancer.
1. Phys Med Biol - published April 4, 2018
2. Hao H, Zhou Z, Li S, Maquilan G, Folkert MR, Iyengar P, Westover KD, Albuquerque K, Liu F, Choy H, Timmerman RD, Yang L, Wang J
Comparison of Uncleaved and Mature Human Immunodeficiency Virus (HIV-1) Membrane Envelope Glycoprotein Trimers.
1. J Virol - published April 4, 2018
2. Castillo-Menendez LR, Witt K, Espy N, Princiotto A, Madani N, Pacheco B, Finzi A, Sodroski J
Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes.
1. EMBO J - published April 3, 2018
2. Brandmann T, Fakim H, Padamsi Z, Youn JY, Gingras AC, Fabian MR, Jinek M
Integrated Structural Biology for α-Helical Membrane Protein Structure Determination.
1. Structure - published April 3, 2018
2. Xia Y, Fischer AW, Teixeira P, Weiner B, Meiler J
CK1/Doubletime activity delays transcription activation in the circadian clock.
1. Elife - published April 3, 2018
2. Top D, O'Neil JL, Merz GE, Dusad K, Crane BR, Young MW
MCM2-7-dependent cohesin loading during S phase promotes sister-chromatid cohesion.
1. Elife - published April 3, 2018
2. Zheng G, Kanchwala M, Xing C, Yu H
Morphometric analysis of spread platelets identifies integrin α_IIbβ₃-specific contractile phenotype.
1. Sci Rep - published April 3, 2018
2. Lickert S, Sorrentino S, Studt JD, Medalia O, Vogel V, Schoen I
Rescue of conformational dynamics in enzyme catalysis by directed evolution.
1. Nat Commun - published April 3, 2018
2. Otten R, Liu L, Kenner LR, Clarkson MW, Mavor D, Tawfik DS, Kern D, Fraser JS
Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy.
1. Cell Death Dis - published April 3, 2018
2. Fabbrizi MR, Meyer B, Misri S, Raj S, Zobel CL, Hallahan DE, Sharma GG
Precise multimodal optical control of neural ensemble activity.
1. Nat Neurosci - published April 3, 2018
2. Mardinly AR, Oldenburg IA, Pégard NC, Sridharan S, Lyall EH, Chesnov K, Brohawn SG, Waller L, Adesnik H
An endogenous dAMP ligand in Bacillus subtilis class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP.
1. Proc Natl Acad Sci U S A - published April 3, 2018
2. Parker MJ, Maggiolo AO, Thomas WC, Kim A, Meisburger SP, Ando N, Boal AK, Stubbe J
RosettaLigandEnsemble: A Small-Molecule Ensemble-Driven Docking Approach.
1. ACS Omega - published April 3, 2018
2. Fu DY, Meiler J
Atomic Resolution Cryo-EM Structure of β-Galactosidase.
1. Structure - published April 3, 2018
2. Bartesaghi A, Aguerrebere C, Falconieri V, Banerjee S, Earl LA, Zhu X, Grigorieff N, Milne JLS, Sapiro G, Wu X, Subramaniam S
Structural and Functional Studies of a Pyran Synthase Domain from a trans-Acyltransferase Assembly Line.
1. ACS Chem Biol - published April 2, 2018
2. Wagner DT, Zhang Z, Meoded RA, Cepeda AJ, Piel J, Keatinge-Clay AT
Identification of small-molecule inhibitors of USP2a.
1. Eur J Med Chem - published April 2, 2018
2. Tomala MD, Magiera-Mularz K, Kubica K, Krzanik S, Zieba B, Musielak B, Pustula M, Popowicz GM, Sattler M, Dubin G, Skalniak L, Holak TA
Determinants of Ligand Subtype-Selectivity at α_1A-Adrenoceptor Revealed Using Saturation Transfer Difference (STD) NMR.
1. ACS Chem Biol - published April 2, 2018
2. Yong KJ, Vaid TM, Shilling PJ, Wu FJ, Williams LM, Deluigi M, Plückthun A, Bathgate RAD, Gooley PR, Scott DJ
Preparation of Tunable Microchips to Visualize Native Protein Complexes for Single-Particle Electron Microscopy.
1. Methods Mol Biol - published April 2, 2018
2. Gilmore BL, Varano AC, Dearnaley W, Liang Y, Marcinkowski BC, Dukes MJ, Kelly DF
Characterizing Intact Macromolecular Complexes Using Native Mass Spectrometry.
1. Methods Mol Biol - published April 2, 2018
2. Boeri Erba E, Signor L, Oliva MF, Hans F, Petosa C
Günter Blobel 1936-2018.
1. Nat Struct Mol Biol - published April 2, 2018
2. Chook YM, Fontoura BMA, Rout MP
Reply to Mortensen et al.: The zymogen form of complement component C1.
1. Proc Natl Acad Sci U S A - published April 2, 2018
2. Almitairi JOM, Venkatraman Girija U, Furze CM, Simpson-Gray X, Badakshi F, Marshall JE, Schwaeble WJ, Mitchell DA, Moody PCE, Wallis R
Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK).
1. J Med Chem - published April 2, 2018
2. Powell CE, Gao Y, Tan L, Donovan KA, Nowak RP, Loehr A, Bahcall M, Fischer ES, Jänne PA, George RE, Gray NS
SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties.
1. PLoS Negl Trop Dis - published April 2, 2018
2. Leontovyč A, Ulrychová L, O'Donoghue AJ, Vondrášek J, Marešová L, Hubálek M, Fajtová P, Chanová M, Jiang Z, Craik CS, Caffrey CR, Mareš M, Dvořák J, Horn M
MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.
1. Science - published April 2, 2018
2. Rocha AG, Franco A, Krezel AM, Rumsey JM, Alberti JM, Knight WC, Biris N, Zacharioudakis E, Janetka JW, Baloh RH, Kitsis RN, Mochly-Rosen D, Townsend RR, Gavathiotis E, Dorn GW 2nd
Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response.
1. Annu Rev Immunol - published April 2, 2018
2. Andreotti AH, Joseph RE, Conley JM, Iwasa J, Berg LJ
Mechanically interlocked functionalization of monoclonal antibodies.
1. Nat Commun - published April 2, 2018
2. Bzymek KP, Puckett JW, Zer C, Xie J, Ma Y, King JD, Goodstein LH, Avery KN, Colcher D, Singh G, Horne DA, Williams JC
PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms.
1. PLoS Pathog - published April 2, 2018
2. Little DJ, Pfoh R, Le Mauff F, Bamford NC, Notte C, Baker P, Guragain M, Robinson H, Pier GB, Nitz M, Deora R, Sheppard DC, Howell PL
Pathogenic Nocardia cyriacigeorgica and Nocardia nova evolve to resist trimethoprim-sulfamethoxazole by both expected and unexpected pathways.
1. Antimicrob Agents Chemother - published April 2, 2018
2. Mehta H, Weng J, Prater A, Elworth RAL, Han X, Shamoo Y
Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β.
1. Sci Rep - published April 2, 2018
2. Arndt JW, Qian F, Smith BA, Quan C, Kilambi KP, Bush MW, Walz T, Pepinsky RB, Bussière T, Hamann S, Cameron TO, Weinreb PH
Spatial and temporal organization of cadherin in punctate adherens junctions.
1. Proc Natl Acad Sci U S A - published April 2, 2018
2. Indra I, Choi J, Chen CS, Troyanovsky RB, Shapiro L, Honig B, Troyanovsky SM
Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.
1. Hum Genet - published April 2, 2018
2. Stephen J, Nampoothiri S, Banerjee A, Tolman NJ, Penninger JM, Elling U, Agu CA, Burke JD, Devadathan K, Kannan R, Huang Y, Steinbach PJ, Martinis SA, Gahl WA, Malicdan MCV
Mimicking a p53-MDM2 interaction based on a stable immunoglobulin-like domain scaffold.
1. Proteins - published April 2, 2018
2. Jimenez-Sandoval P, Madrigal-Carrillo EA, Santamaría-Suárez HA, Maturana D, Rentería-González I, Benitez-Cardoza CG, Torres-Larios A, Brieba LG
Architecture of an HIV-1 reverse transcriptase initiation complex.
1. Nature - published April 2, 2018
2. Larsen KP, Mathiharan YK, Kappel K, Coey AT, Chen DH, Barrero D, Madigan L, Puglisi JD, Skiniotis G, Puglisi EV
In vitro synthesis of gene-length single-stranded DNA.
1. Sci Rep - published April 2, 2018
2. Veneziano R, Shepherd TR, Ratanalert S, Bellou L, Tao C, Bathe M
Quantitative mass imaging of single biological macromolecules.
1. Science - published April 2, 2018
2. Young G, Hundt N, Cole D, Fineberg A, Andrecka J, Tyler A, Olerinyova A, Ansari A, Marklund EG, Collier MP, Chandler SA, Tkachenko O, Allen J, Crispin M, Billington N, Takagi Y, Sellers JR, Eichmann C, Selenko P, Frey L, Riek R, Galpin MR, Struwe WB, Benesch JLP, Kukura P
Disruption of an oligomeric interface prevents allosteric inhibition of Escherichia coli class Ia ribonucleotide reductase.
1. J Biol Chem - published April 2, 2018
2. Chen PY, Funk MA, Brignole EJ, Drennan CL
Günter Blobel (1936-2018).
1. Science - published April 2, 2018
2. Walter P, Anderson D
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
1. Nat Genet - published April 2, 2018
2. Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, Adams MJ, Agerbo E, Air TM, Andlauer TMF, Bacanu SA, Bækvad-Hansen M, Beekman AFT, Bigdeli TB, Binder EB, Blackwood DRH, Bryois J, Buttenschøn HN, Bybjerg-Grauholm J, Cai N, Castelao E, Christensen JH, Clarke TK, Coleman JIR, Colodro-Conde L, Couvy-Duchesne B, Craddock N, Crawford GE, Crowley CA, Dashti HS, Davies G, Deary IJ, Degenhardt F, Derks EM, Direk N, Dolan CV, Dunn EC, Eley TC, Eriksson N, Escott-Price V, Kiadeh FHF, Finucane HK, Forstner AJ, Frank J, Gaspar HA, Gill M, Giusti-Rodríguez P, Goes FS, Gordon SD, Grove J, Hall LS, Hannon E, Hansen CS, Hansen TF, Herms S, Hickie IB, Hoffmann P, Homuth G, Horn C, Hottenga JJ, Hougaard DM, Hu M, Hyde CL, Ising M, Jansen R, Jin F, Jorgenson E, Knowles JA, Kohane IS, Kraft J, Kretzschmar WW, Krogh J, Kutalik Z, Lane JM, Li Y, Li Y, Lind PA, Liu X, Lu L, MacIntyre DJ, MacKinnon DF, Maier RM, Maier W, Marchini J, Mbarek H, McGrath P, McGuffin P, Medland SE, Mehta D, Middeldorp CM, Mihailov E, Milaneschi Y, Milani L, Mill J, Mondimore FM, Montgomery GW, Mostafavi S, Mullins N, Nauck M, Ng B, Nivard MG, Nyholt DR, O'Reilly PF, Oskarsson H, Owen MJ, Painter JN, Pedersen CB, Pedersen MG, Peterson RE, Pettersson E, Peyrot WJ, Pistis G, Posthuma D, Purcell SM, Quiroz JA, Qvist P, Rice JP, Riley BP, Rivera M, Saeed Mirza S, Saxena R, Schoevers R, Schulte EC, Shen L, Shi J, Shyn SI, Sigurdsson E, Sinnamon GBC, Smit JH, Smith DJ, Stefansson H, Steinberg S, Stockmeier CA, Streit F, Strohmaier J, Tansey KE, Teismann H, Teumer A, Thompson W, Thomson PA, Thorgeirsson TE, Tian C, Traylor M, Treutlein J, Trubetskoy V, Uitterlinden AG, Umbricht D, Van der Auwera S, van Hemert AM, Viktorin A, Visscher PM, Wang Y, Webb BT, Weinsheimer SM, Wellmann J, Willemsen G, Witt SH, Wu Y, Xi HS, Yang J, Zhang F, eQTLGen., 23andMe., Arolt V, Baune BT, Berger K, Boomsma DI, Cichon S, Dannlowski U, de Geus ECJ, DePaulo JR, Domenici E, Domschke K, Esko T, Grabe HJ, Hamilton SP, Hayward C, Heath AC, Hinds DA, Kendler KS, Kloiber S, Lewis G, Li QS, Lucae S, Madden PFA, Magnusson PK, Martin NG, McIntosh AM, Metspalu A, Mors O, Mortensen PB, Müller-Myhsok B, Nordentoft M, Nöthen MM, O'Donovan MC, Paciga SA, Pedersen NL, Penninx BWJH, Perlis RH, Porteous DJ, Potash JB, Preisig M, Rietschel M, Schaefer C, Schulze TG, Smoller JW, Stefansson K, Tiemeier H, Uher R, Völzke H, Weissman MM, Werge T, Winslow AR, Lewis CM, Levinson DF, Breen G, Børglum AD, Sullivan PF, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium.
Field-deployable viral diagnostics using CRISPR-Cas13.
1. Science - published April 2, 2018
2. Myhrvold C, Freije CA, Gootenberg JS, Abudayyeh OO, Metsky HC, Durbin AF, Kellner MJ, Tan AL, Paul LM, Parham LA, Garcia KF, Barnes KG, Chak B, Mondini A, Nogueira ML, Isern S, Michael SF, Lorenzana I, Yozwiak NL, MacInnis BL, Bosch I, Gehrke L, Zhang F, Sabeti PC
Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain.
1. J Biol Chem - published April 2, 2018
2. Peng L, Zhang F, Shang R, Wang X, Chen J, Chou JJ, Ma J, Wu L, Huang Y
Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.
1. Nat Commun - published April 2, 2018
2. Schulze WM, Stein F, Rettel M, Nanao M, Cusack S
Epithelial barrier dysfunction in Desmoglein-1 deficiency.
1. J Allergy Clin Immunol - published April 2, 2018
2. Polivka L, Hadj-Rabia S, Bal E, Leclerc-Mercier S, Madrange M, Hamel Y, Bonnet D, Mallet S, Lepidi H, Ovaert C, Barbet P, Dupont C, Neven B, Munnich A, Godsel LM, Campeotto F, Weil R, Laplantine E, Marchetto S, Borg JP, Weis WI, Casanova JL, Puel A, Green KJ, Bodemer C, Smahi A
Ca2+-Triggered Synaptic Vesicle Fusion Initiated by Release of Inhibition.
1. Trends Cell Biol - published April 2, 2018
2. Brunger AT, Leitz J, Zhou Q, Choi UB, Lai Y
The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair.
1. Annu Rev Biochem - published April 2, 2018
2. Syed A, Tainer JA
Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics.
1. ACS Cent Sci - published April 2, 2018
2. Watson EE, Liu X, Thompson RE, Ripoll-Rozada J, Wu M, Alwis I, Gori A, Loh CT, Parker BL, Otting G, Jackson S, Pereira PJB, Payne RJ
Iriomoteolides: novel chemical tools to study actin dynamics.
1. Chem Sci - published April 2, 2018
2. Unzue A, Cribiú R, Hoffman MM, Knehans T, Lafleur K, Caflisch A, Nevado C
MicroED: a versatile cryoEM method for structure determination.
1. Emerg Top Life Sci - published April 2, 2018
2. Nannenga BL, Gonen T
Capturing dynamic conformational shifts in protein-ligand recognition using integrative structural biology in solution.
1. Emerg Top Life Sci - published April 2, 2018
2. Kang HS, Sattler M
Unprecedented anticancer activities of organorhenium sulfonato and carboxylato complexes against hormone-dependent MCF-7 and hormone-independent triple-negative MDA-MB-231 breast cancer cells.
1. Mol Cell Biochem - published April 1, 2018
2. Wilder PT, Weber DJ, Winstead A, Parnell S, Hinton TV, Stevenson M, Giri D, Azemati S, Olczak P, Powell BV, Odebode T, Tadesse S, Zhang Y, Pramanik SK, Wachira JM, Ghimire S, McCarthy P, Barfield A, Banerjee HN, Chen C, Golen JA, Rheingold AL, Krause JA, Ho DM, Zavalij PY, Shaw R, Mandal SK
Backbone resonance assignment of the BCL6-BTB/POZ domain.
1. Biomol NMR Assign - published April 1, 2018
2. Lin LY, Evans SE, Fairall L, Schwabe JWR, Wagner SD, Muskett FW
PaRSnIP: sequence-based protein solubility prediction using gradient boosting machine.
1. Bioinformatics - published April 1, 2018
2. Rawi R, Mall R, Kunji K, Shen CH, Kwong PD, Chuang GY
Biased signalling: from simple switches to allosteric microprocessors.
1. Nat Rev Drug Discov - published April 1, 2018
2. Smith JS, Lefkowitz RJ, Rajagopal S
Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGFβ1 antibody.
1. MAbs - published April 1, 2018
2. Lord DM, Bird JJ, Honey DM, Best A, Park A, Wei RR, Qiu H
Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy.
1. J Physiol - published April 1, 2018
2. Lau C, Hunter MJ, Stewart A, Perozo E, Vandenberg JI
Dynamics of human telomerase recruitment depend on template-telomere base pairing.
1. Mol Biol Cell - published April 1, 2018
2. Schmidt JC, Zaug AJ, Kufer R, Cech TR
Assembly and structure of the SSU processome-a nucleolar precursor of the small ribosomal subunit.
1. Curr Opin Struct Biol - published April 1, 2018
2. Barandun J, Hunziker M, Klinge S
Synonymous Mutations at the Beginning of the Influenza A Virus Hemagglutinin Gene Impact Experimental Fitness.
1. J Mol Biol - published April 1, 2018
2. Canale AS, Venev SV, Whitfield TW, Caffrey DR, Marasco WA, Schiffer CA, Kowalik TF, Jensen JD, Finberg RW, Zeldovich KB, Wang JP, Bolon DNA
Peptide-Guided Assembly of Repeat Protein Fragments.
1. Angew Chem Int Ed Engl - published April 1, 2018
2. Michel E, Plückthun A, Zerbe O
Grouper iridovirus GIV66 is a Bcl-2 protein that inhibits apoptosis by exclusively sequestering Bim.
1. J Biol Chem - published April 1, 2018
2. Banjara S, Mao J, Ryan TM, Caria S, Kvansakul M
Does industry funding mean more publications for subspecialty academic plastic surgeons?
1. J Surg Res - published April 1, 2018
2. Ruan QZ, Cohen JB, Baek Y, Bletsis P, Celestin AR, Epstein S, Bucknor AEM, Lee BT
The RING domain of RING Finger 11 (RNF11) protein binds Ubc13 and inhibits formation of polyubiquitin chains.
1. FEBS Lett - published April 1, 2018
2. Budhidarmo R, Zhu J, Middleton AJ, Day CL
Author Correction: Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.
1. Nat Struct Mol Biol - published April 1, 2018
2. Clerici M, Faini M, Muckenfuss LM, Aebersold R, Jinek M
Morphological characterization of a plant-made virus-like particle vaccine bearing influenza virus hemagglutinins by electron microscopy.
1. Vaccine - published April 1, 2018
2. Lindsay BJ, Bonar MM, Costas-Cancelas IN, Hunt K, Makarkov AI, Chierzi S, Krawczyk CM, Landry N, Ward BJ, Rouiller I
Unprecedented Role of Hybrid N-Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies.
1. J Am Chem Soc - published April 1, 2018
2. Shivatare VS, Shivatare SS, Lee CD, Liang CH, Liao KS, Cheng YY, Saidachary G, Wu CY, Lin NH, Kwong PD, Burton DR, Wu CY, Wong CH
Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling.
1. Proc Natl Acad Sci U S A - published April 1, 2018
2. Staus DP, Wingler LM, Choi M, Pani B, Manglik A, Kruse AC, Lefkowitz RJ
Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state.
1. Proc Natl Acad Sci U S A - published April 1, 2018
2. Zhang X, Wang Q, Wu J, Wang J, Shi Y, Liu M
Investigating the Dynamics of Destabilized Nucleosomes Using Methyl-TROSY NMR.
1. J Am Chem Soc - published April 1, 2018
2. Kitevski-LeBlanc JL, Yuwen T, Dyer PN, Rudolph J, Luger K, Kay LE
Günter Blobel (1936-2018).
1. Nat Cell Biol - published April 1, 2018
2. Hoelz A
Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation.
1. Nat Struct Mol Biol - published April 1, 2018
2. Luo F, Gui X, Zhou H, Gu J, Li Y, Liu X, Zhao M, Li D, Li X, Liu C
Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations.
1. Nat Commun - published April 1, 2018
2. Ye L, Neale C, Sljoka A, Lyda B, Pichugin D, Tsuchimura N, Larda ST, Pomès R, García AE, Ernst OP, Sunahara RK, Prosser RS
Taxonomy of the order Mononegavirales: update 2018.
1. Arch Virol - published April 1, 2018
2. Amarasinghe GK, Aréchiga Ceballos NG, Banyard AC, Basler CF, Bavari S, Bennett AJ, Blasdell KR, Briese T, Bukreyev A, Caì Y, Calisher CH, Campos Lawson C, Chandran K, Chapman CA, Chiu CY, Choi KS, Collins PL, Dietzgen RG, Dolja VV, Dolnik O, Domier LL, Dürrwald R, Dye JM, Easton AJ, Ebihara H, Echevarría JE, Fooks AR, Formenty PBH, Fouchier RAM, Freuling CM, Ghedin E, Goldberg TL, Hewson R, Horie M, Hyndman TH, Jiāng D, Kityo R, Kobinger GP, Kondō H, Koonin EV, Krupovic M, Kurath G, Lamb RA, Lee B, Leroy EM, Maes P, Maisner A, Marston DA, Mor SK, Müller T, Mühlberger E, Ramírez VMN, Netesov SV, Ng TFF, Nowotny N, Palacios G, Patterson JL, Pawęska JT, Payne SL, Prieto K, Rima BK, Rota P, Rubbenstroth D, Schwemmle M, Siddell S, Smither SJ, Song Q, Song T, Stenglein MD, Stone DM, Takada A, Tesh RB, Thomazelli LM, Tomonaga K, Tordo N, Towner JS, Vasilakis N, Vázquez-Morón S, Verdugo C, Volchkov VE, Wahl V, Walker PJ, Wang D, Wang LF, Wellehan JFX, Wiley MR, Whitfield AE, Wolf YI, Yè G, Zhāng YZ, Kuhn JH
A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers.
1. Cell Rep - published April 1, 2018
2. Rutten L, Lai YT, Blokland S, Truan D, Bisschop IJM, Strokappe NM, Koornneef A, van Manen D, Chuang GY, Farney SK, Schuitemaker H, Kwong PD, Langedijk JPM
Crystallographic Trapping of Reaction Intermediates in Quinolinic Acid Synthesis by NadA.
1. ACS Chem Biol - published April 1, 2018
2. Volbeda A, Saez Cabodevilla J, Darnault C, Gigarel O, Han TH, Renoux O, Hamelin O, Ollagnier-de-Choudens S, Amara P, Fontecilla-Camps JC
The HIRAN domain of helicase-like transcription factor positions the DNA translocase motor to drive efficient DNA fork regression.
1. J Biol Chem - published April 1, 2018
2. Chavez DA, Greer BH, Eichman BF
Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa.
1. BMC Evol Biol - published April 1, 2018
2. Lokits AD, Indrischek H, Meiler J, Hamm HE, Stadler PF
Neutralizing Antibody Responses following Long-Term Vaccination with HIV-1 Env gp140 in Guinea Pigs.
1. J Virol - published April 1, 2018
2. Bricault CA, Kovacs JM, Badamchi-Zadeh A, McKee K, Shields JL, Gunn BM, Neubauer GH, Ghantous F, Jennings J, Gillis L, Perry J, Nkolola JP, Alter G, Chen B, Stephenson KE, Doria-Rose N, Mascola JR, Seaman MS, Barouch DH
The crystal structure of the malic enzyme from Candidatus Phytoplasma reveals the minimal structural determinants for a malic enzyme.
1. Acta Crystallogr D Struct Biol - published April 1, 2018
2. Alvarez CE, Trajtenberg F, Larrieux N, Saigo M, Golic A, Andreo CS, Hogenhout SA, Mussi MA, Drincovich MF, Buschiazzo A
Towards the structural characterization of the human methyltransferome.
1. Curr Opin Struct Biol - published April 1, 2018
2. Fenwick MK, Ealick SE
Targeting intrinsically disordered transcription factors: Changing the paradigm.
1. J Mol Biol - published April 1, 2018
2. Tsafou K, Tiwari PB, Forman-Kay JD, Metallo SJ, Toretsky JA
Plasmodium falciparum Falcipain-2a Polymorphisms in Southeast Asia and Their Association with Artemisinin Resistance.
1. J Infect Dis - published April 1, 2018
2. Siddiqui FA, Cabrera M, Wang M, Brashear A, Kemirembe K, Wang Z, Miao J, Chookajorn T, Yang Z, Cao Y, Dong G, Rosenthal PJ, Cui L
Racial disparities in postmastectomy breast reconstruction: National trends in utilization from 2005 to 2014.
1. Cancer - published April 1, 2018
2. Epstein S, Tran BN, Cohen JB, Lin SJ, Singhal D, Lee BT
Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors.
1. Neuron - published April 1, 2018
2. Regan MC, Grant T, McDaniel MJ, Karakas E, Zhang J, Traynelis SF, Grigorieff N, Furukawa H
A switch point in the molecular chaperone Hsp90 responding to client interaction.
1. Nat Commun - published April 1, 2018
2. Rutz DA, Luo Q, Freiburger L, Madl T, Kaila VRI, Sattler M, Buchner J
Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance.
1. Nat Rev Cancer - published April 1, 2018
2. Katzenellenbogen JA, Mayne CG, Katzenellenbogen BS, Greene GL, Chandarlapaty S
Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic.
1. Nat Chem Biol - published April 1, 2018
2. Santiago M, Lee W, Fayad AA, Coe KA, Rajagopal M, Do T, Hennessen F, Srisuknimit V, Müller R, Meredith TC, Walker S
In Vivo Structures of the Helicobacter pylori cag Type IV Secretion System.
1. Cell Rep - published April 1, 2018
2. Chang YW, Shaffer CL, Rettberg LA, Ghosal D, Jensen GJ
Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.
1. Nature - published April 1, 2018
2. Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, Duncan D, Bregman H, Keskin A, Santeford A, Apte RS, Sehgal R, Johnson B, Amarasinghe GK, Soares MP, Satoh T, Akira S, Hai T, de Guzman Strong C, Auclair K, Roddy TP, Biller SA, Jovanovic M, Klechevsky E, Stewart KM, Randolph GJ, Artyomov MN
Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains.
1. Cell - published April 1, 2018
2. Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, Taylor JP, Shorter J
Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
1. Cell - published April 1, 2018
2. Yoshizawa T, Ali R, Jiou J, Fung HYJ, Burke KA, Kim SJ, Lin Y, Peeples WB, Saltzberg D, Soniat M, Baumhardt JM, Oldenbourg R, Sali A, Fawzi NL, Rosen MK, Chook YM
Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse.
1. Cell - published April 1, 2018
2. Li J, Shalev-Benami M, Sando R, Jiang X, Kibrom A, Wang J, Leon K, Katanski C, Nazarko O, Lu YC, Südhof TC, Skiniotis G, Araç D
Covalently circularized nanodiscs; challenges and applications.
1. Curr Opin Struct Biol - published April 1, 2018
2. Nasr ML, Wagner G
Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.
1. Cell - published April 1, 2018
2. Hofweber M, Hutten S, Bourgeois B, Spreitzer E, Niedner-Boblenz A, Schifferer M, Ruepp MD, Simons M, Niessing D, Madl T, Dormann D
Molecular pathways for antigenic peptide generation by ER aminopeptidase 1.
1. Mol Immunol - published April 1, 2018
2. Mpakali A, Maben Z, Stern LJ, Stratikos E
Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.
1. Nucleic Acids Res - published April 1, 2018
2. Dolot R, Lam CH, Sierant M, Zhao Q, Liu FW, Nawrot B, Egli M, Yang X
Analysis of Global and Site-Specific Radiation Damage in Cryo-EM.
1. Structure - published April 1, 2018
2. Hattne J, Shi D, Glynn C, Zee CT, Gallagher-Jones M, Martynowycz MW, Rodriguez JA, Gonen T