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133 Member Publications for March 2018

Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira.
1. Front Cell Infect Microbiol - published March 31, 2018
2. Adhikarla H, Wunder EA Jr, Mechaly AE, Mehta S, Wang Z, Santos L, Bisht V, Diggle P, Murray G, Adler B, Lopez F, Townsend JP, Groisman E, Picardeau M, Buschiazzo A, Ko AI
Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies.
1. PLoS One - published March 30, 2018
2. Ziegler SJ, Liu C, Landau M, Buzovetsky O, Desimmie BA, Zhao Q, Sasaki T, Burdick RC, Pathak VK, Anderson KS, Xiong Y
From Stores to Sinks: Structural Mechanisms of Cytosolic Calcium Regulation.
1. Adv Exp Med Biol - published March 30, 2018
2. Enomoto M, Nishikawa T, Siddiqui N, Chung S, Ikura M, Stathopulos PB
Arkadia (RING Finger Protein 111) Mediates Sumoylation-Dependent Stabilization of Nrf2 Through K48-Linked Ubiquitination.
1. Cell Physiol Biochem - published March 30, 2018
2. McIntosh DJ, Walters TS, Arinze IJ, Davis J
Characterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors.
1. PLoS One - published March 21, 2018
2. González N, McKee K, Lynch RM, Georgiev IS, Jimenez L, Grau E, Yuste E, Kwong PD, Mascola JR, Alcamí J
Caring for Hereditary Childhood Retinal Blindness.
1. Asia Pac J Ophthalmol (Phila) - published March 15, 2018
2. Jauregui R, Cho GY, Takahashi VKL, Takiuti JT, Bassuk AG, Mahajan VB, Tsang SH
Modification of the kinetic stability of immunoglobulin G by solvent additives.
1. MAbs - published March 15, 2018
2. Schaefer JV, Sedlák E, Kast F, Nemergut M, Plückthun A
Preface.
1. Methods Enzymol - published March 11, 2018
2. Spies M, Malkova A
Integrating Experimental and In Silico HTS in the Discovery of Inhibitors of Protein-Nucleic Acid Interactions.
1. Methods Enzymol - published March 11, 2018
2. Li Q, Folly da Silva Constantino L, Spies MA
Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities.
1. Methods Enzymol - published March 11, 2018
2. Moiani D, Ronato DA, Brosey CA, Arvai AS, Syed A, Masson JY, Petricci E, Tainer JA
Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design.
1. J Med Chem - published March 9, 2018
2. Shaw S, Bian Z, Zhao B, Tarr JC, Veerasamy N, Jeon KO, Belmar J, Arnold AL, Fogarty SA, Perry E, Sensintaffar JL, Camper DV, Rossanese OW, Lee T, Olejniczak ET, Fesik SW
Fragment-to-Lead Medicinal Chemistry Publications in 2016.
1. J Med Chem - published March 8, 2018
2. Johnson CN, Erlanson DA, Jahnke W, Mortenson PN, Rees DC
The Three-Dimensional Structure of NeoB: An Aminotransferase Involved in the Biosynthesis of Neomycin.
1. Protein Sci - published March 8, 2018
2. Dow GT, Thoden JB, Holden HM
Sumoylation promotes optimal APC/C activation and timely anaphase.
1. Elife - published March 8, 2018
2. Lee CC, Li B, Yu H, Matunis MJ
Precision antimicrobial therapeutics: the path of least resistance?
1. NPJ Biofilms Microbiomes - published March 7, 2018
2. Spaulding CN, Klein RD, Schreiber HL 4th, Janetka JW, Hultgren SJ
cisTEM, User-friendly software for single-particle image processing.
1. Elife - published March 7, 2018
2. Grant T, Rohou A, Grigorieff N
The HUS-box is required for allosteric regulation of the Sec7 Arf-GEF.
1. J Biol Chem - published March 7, 2018
2. Halaby SL, Fromme JC
Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability.
1. Immunity - published March 7, 2018
2. Johnson B, VanBlargan LA, Xu W, White JP, Shan C, Shi PY, Zhang R, Adhikari J, Gross ML, Leung DW, Diamond MS, Amarasinghe GK
Deciphering the "Fuzzy" Interaction of FG Nucleoporins and Transport Factors Using Small-Angle Neutron Scattering.
1. Structure - published March 6, 2018
2. Sparks S, Temel DB, Rout MP, Cowburn D
Tuning Inner-Ear Tip-Link Affinity Through Alternatively Spliced Variants of Protocadherin-15.
1. Biochemistry - published March 6, 2018
2. Narui Y, Sotomayor M
Structure-based discovery of selective positive allosteric modulators of antagonists for the M₂ muscarinic acetylcholine receptor.
1. Proc Natl Acad Sci U S A - published March 6, 2018
2. Korczynska M, Clark MJ, Valant C, Xu J, Moo EV, Albold S, Weiss DR, Torosyan H, Huang W, Kruse AC, Lyda BR, May LT, Baltos JA, Sexton PM, Kobilka BK, Christopoulos A, Shoichet BK, Sunahara RK
Current Insights of BRAF Inhibitors in Cancer.
1. J Med Chem - published March 6, 2018
2. Agianian B, Gavathiotis E
Substrate binding to BamD triggers a conformational change in BamA to control membrane insertion.
1. Proc Natl Acad Sci U S A - published March 6, 2018
2. Lee J, Sutterlin HA, Wzorek JS, Mandler MD, Hagan CL, Grabowicz M, Tomasek D, May MD, Hart EM, Silhavy TJ, Kahne D
Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies.
1. Proc Natl Acad Sci U S A - published March 6, 2018
2. Swatek KN, Aumayr M, Pruneda JN, Visser LJ, Berryman S, Kueck AF, Geurink PP, Ovaa H, van Kuppeveld FJM, Tuthill TJ, Skern T, Komander D
Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies.
1. PLoS Pathog - published March 6, 2018
2. Jones HG, Ritschel T, Pascual G, Brakenhoff JPJ, Keogh E, Furmanova-Hollenstein P, Lanckacker E, Wadia JS, Gilman MSA, Williamson RA, Roymans D, van 't Wout AB, Langedijk JP, McLellan JS
Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition.
1. Sci Signal - published March 6, 2018
2. Jones DS, Jenney AP, Joughin BA, Sorger PK, Lauffenburger DA
Interplay between conformational selection and zymogen activation.
1. Sci Rep - published March 6, 2018
2. Chakraborty P, Acquasaliente L, Pelc LA, Di Cera E
The Optimization of an eHealth Solution (Thought Spot) with Transition-Aged Youth in Postsecondary Settings: Participatory Design Research.
1. J Med Internet Res - published March 6, 2018
2. VanHeerwaarden N, Ferguson G, Abi-Jaoude A, Johnson A, Hollenberg E, Chaim G, Cleverley K, Eysenbach G, Henderson J, Levinson A, Robb J, Sharpe S, Voineskos A, Wiljer D
O-GlcNAc Transferase Recognizes Protein Substrates Using an Asparagine Ladder in the Tetratricopeptide Repeat (TPR) Superhelix.
1. J Am Chem Soc - published March 5, 2018
2. Levine ZG, Fan C, Melicher MS, Orman M, Benjamin T, Walker S
Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system.
1. Proc Natl Acad Sci U S A - published March 5, 2018
2. Liu Y, Gonen S, Gonen T, Yeates TO
Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.
1. Nat Chem Biol - published March 5, 2018
2. Gechijian LN, Buckley DL, Lawlor MA, Reyes JM, Paulk J, Ott CJ, Winter GE, Erb MA, Scott TG, Xu M, Seo HS, Dhe-Paganon S, Kwiatkowski NP, Perry JA, Qi J, Gray NS, Bradner JE
Ligand and cation-induced structural alterations of the leukocyte integrin LFA-1.
1. J Biol Chem - published March 5, 2018
2. Sen M, Koksal AC, Yuki K, Wang J, Springer TA
Life times of metastable states guide regulatory signaling in transcriptional riboswitches.
1. Nat Commun - published March 5, 2018
2. Helmling C, Klötzner DP, Sochor F, Mooney RA, Wacker A, Landick R, Fürtig B, Heckel A, Schwalbe H
Dissecting super-enhancer hierarchy based on chromatin interactions.
1. Nat Commun - published March 5, 2018
2. Huang J, Li K, Cai W, Liu X, Zhang Y, Orkin SH, Xu J, Yuan GC
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.
1. Science - published March 3, 2018
2. Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P
Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis.
1. ACS Infect Dis - published March 3, 2018
2. Ngo HX, Green KD, Gajadeera CS, Willby MJ, Holbrook SYL, Hou C, Garzan A, Mayhoub AS, Posey JE, Tsodikov OV, Garneau-Tsodikova S
PIK3CB/p110β is a selective survival factor for glioblastoma.
1. Neuro Oncol - published March 2, 2018
2. Pridham KJ, Le L, Guo S, Varghese RT, Algino S, Liang Y, Fajardin R, Rodgers CM, Simonds GR, Kelly DF, Sheng Z
Thermodynamic characterization of the multivalent interactions underlying rapid and selective translocation through the nuclear pore complex.
1. J Biol Chem - published March 2, 2018
2. Hayama R, Sparks S, Hecht LM, Dutta K, Karp JM, Cabana CM, Rout MP, Cowburn D
Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large.
1. J Biol Chem - published March 2, 2018
2. Caria S, Magtoto CM, Samiei T, Portela M, Lim KYB, How JY, Stewart BZ, Humbert PO, Richardson HE, Kvansakul M
Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference.
1. Proc Natl Acad Sci U S A - published March 2, 2018
2. Li J, Wu C, Wang W, He Y, Elkayam E, Joshua-Tor L, Hammond PT
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes.
1. Science - published March 2, 2018
2. Sockolosky JT, Trotta E, Parisi G, Picton L, Su LL, Le AC, Chhabra A, Silveria SL, George BM, King IC, Tiffany MR, Jude K, Sibener LV, Baker D, Shizuru JA, Ribas A, Bluestone JA, Garcia KC
A mechanism for CO regulation of ion channels.
1. Nat Commun - published March 2, 2018
2. Kapetanaki SM, Burton MJ, Basran J, Uragami C, Moody PCE, Mitcheson JS, Schmid R, Davies NW, Dorlet P, Vos MH, Storey NM, Raven E
Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection.
1. Proc Natl Acad Sci U S A - published March 2, 2018
2. Kalas V, Hibbing ME, Maddirala AR, Chugani R, Pinkner JS, Mydock-McGrane LK, Conover MS, Janetka JW, Hultgren SJ
Multiplexed Immunofluorescence Reveals Potential PD-1/PD-L1 Pathway Vulnerabilities in Craniopharyngioma.
1. Neuro Oncol - published March 2, 2018
2. Coy S, Rashid R, Lin JR, Du Z, Donson AM, Hankinson TC, Foreman NK, Manley PE, Kieran MW, Reardon DA, Sorger PK, Santagata S
Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis.
1. Proc Natl Acad Sci U S A - published March 2, 2018
2. Hudson BH, Hale AT, Irving RP, Li S, York JD
Bilobal architecture is a requirement for calmodulin signaling to Ca_V1.3 channels.
1. Proc Natl Acad Sci U S A - published March 2, 2018
2. Banerjee R, Yoder JB, Yue DT, Amzel LM, Tomaselli GF, Gabelli SB, Ben-Johny M
Integrative structure and functional anatomy of a nuclear pore complex.
1. Nature - published March 2, 2018
2. Kim SJ, Fernandez-Martinez J, Nudelman I, Shi Y, Zhang W, Raveh B, Herricks T, Slaughter BD, Hogan JA, Upla P, Chemmama IE, Pellarin R, Echeverria I, Shivaraju M, Chaudhury AS, Wang J, Williams R, Unruh JR, Greenberg CH, Jacobs EY, Yu Z, de la Cruz MJ, Mironska R, Stokes DL, Aitchison JD, Jarrold MF, Gerton JL, Ludtke SJ, Akey CW, Chait BT, Sali A, Rout MP
Antibiotic Combinations That Enable One-Step, Targeted Mutagenesis of Chromosomal Genes.
1. ACS Infect Dis - published March 2, 2018
2. Lee W, Do T, Zhang G, Kahne D, Meredith TC, Walker S
Atomistic Mechanism of Large-Scale Conformational Transition in a Heterodimeric ABC Exporter.
1. J Am Chem Soc - published March 2, 2018
2. Göddeke H, Timachi MH, Hutter CAJ, Galazzo L, Seeger MA, Karttunen M, Bordignon E, Schäfer LV
A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.
1. Immunity - published March 2, 2018
2. Zhou T, Zheng A, Baxa U, Chuang GY, Georgiev IS, Kong R, O'Dell S, Shahzad-Ul-Hussan S, Shen CH, Tsybovsky Y, Bailer RT, Gift SK, Louder MK, McKee K, Rawi R, Stevenson CH, Stewart-Jones GBE, Taft JD, Waltari E, Yang Y, Zhang B, Shivatare SS, Shivatare VS, Lee CD, Wu CY, NISC Comparative Sequencing Program., Mullikin JC, Bewley CA, Burton DR, Polonis VR, Shapiro L, Wong CH, Mascola JR, Kwong PD, Wu X
Transposase-DNA Complex Structures Reveal Mechanisms for Conjugative Transposition of Antibiotic Resistance.
1. Cell - published March 2, 2018
2. Rubio-Cosials A, Schulz EC, Lambertsen L, Smyshlyaev G, Rojas-Cordova C, Forslund K, Karaca E, Bebel A, Bork P, Barabas O
Structures of the Catalytic Domain of Bacterial Primase DnaG in Complexes with DNA Provide Insight into Key Priming Events.
1. Biochemistry - published March 2, 2018
2. Hou C, Biswas T, Tsodikov OV
Membrane Potential Is Required for MurJ Function.
1. J Am Chem Soc - published March 2, 2018
2. Rubino FA, Kumar S, Ruiz N, Walker S, Kahne DE
Influences: Short circuits.
1. J Gen Physiol - published March 2, 2018
2. Clapham DE
HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations.
1. Elife - published March 2, 2018
2. Ma X, Lu M, Gorman J, Terry DS, Hong X, Zhou Z, Zhao H, Altman RB, Arthos J, Blanchard SC, Kwong PD, Munro JB, Mothes W
Vitamin E-based glycoside amphiphiles for membrane protein structural studies.
1. Org Biomol Chem - published March 2, 2018
2. Ehsan M, Du Y, Molist I, Seven AB, Hariharan P, Mortensen JS, Ghani L, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS
Molecular control of gene expression by Brucella BaaR, an IclR-type transcriptional repressor.
1. J Biol Chem - published March 2, 2018
2. Herrou J, Czyż DM, Fiebig A, Willett JW, Kim Y, Wu R, Babnigg G, Crosson S
Structure of a prehandover mammalian ribosomal SRP•SRP receptor targeting complex.
1. Science - published March 2, 2018
2. Kobayashi K, Jomaa A, Lee JH, Chandrasekar S, Boehringer D, Shan SO, Ban N
Altered compensatory cytokine signaling underlies the discrepancy between Flt3-/- and Flt3l-/- mice.
1. J Exp Med - published March 2, 2018
2. Durai V, Bagadia P, Briseño CG, Theisen DJ, Iwata A, Davidson JT 4th, Gargaro M, Fremont DH, Murphy TL, Murphy KM
Structure and evolution of the Fam20 kinases.
1. Nat Commun - published March 2, 2018
2. Zhang H, Zhu Q, Cui J, Wang Y, Chen MJ, Guo X, Tagliabracci VS, Dixon JE, Xiao J
Differential effects on enzyme stability and kinetic parameters of mutants related to human triosephosphate isomerase deficiency.
1. Biochim Biophys Acta - published March 2, 2018
2. Cabrera N, Torres-Larios A, García-Torres I, Enríquez-Flores S, Perez-Montfort R
A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors.
1. Nat Commun - published March 2, 2018
2. Vigolo M, Chambers MG, Willen L, Chevalley D, Maskos K, Lammens A, Tardivel A, Das D, Kowalczyk-Quintas C, Schuepbach-Mallepell S, Smulski CR, Eslami M, Rolink A, Hummler E, Samy E, Fomekong Nanfack Y, Mackay F, Liao M, Hess H, Jiang X, Schneider P
Surgical site infection in immediate breast reconstruction: Does chemotherapy timing make a difference?
1. J Surg Oncol - published March 2, 2018
2. Chattha AS, Cohen JB, Bucknor A, Chen AD, Tobias AM, Lee BT, Lin SJ
Binding site for coenzyme A revealed in the structure of pyruvate:ferredoxin oxidoreductase from Moorella thermoacetica.
1. Proc Natl Acad Sci U S A - published March 2, 2018
2. Chen PY, Aman H, Can M, Ragsdale SW, Drennan CL
The power of synthetic biology for bioproduction, remediation and pollution control: The UN's Sustainable Development Goals will inevitably require the application of molecular biology and biotechnology on a global scale.
1. EMBO Rep - published March 2, 2018
2. de Lorenzo V, Prather KL, Chen GQ, O'Day E, von Kameke C, Oyarzún DA, Hosta-Rigau L, Alsafar H, Cao C, Ji W, Okano H, Roberts RJ, Ronaghi M, Yeung K, Zhang F, Lee SY
Circadian clock activity of cryptochrome relies on tryptophan-mediated photoreduction.
1. Proc Natl Acad Sci U S A - published March 2, 2018
2. Lin C, Top D, Manahan CC, Young MW, Crane BR
Active Site Flexibility as a Hallmark for Efficient PET Degradation by I. sakaiensis PETase.
1. Biophys J - published March 2, 2018
2. Fecker T, Galaz-Davison P, Engelberger F, Narui Y, Sotomayor M, Parra LP, Ramírez-Sarmiento CA
Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis.
1. Nature - published March 2, 2018
2. Sjodt M, Brock K, Dobihal G, Rohs PDA, Green AG, Hopf TA, Meeske AJ, Srisuknimit V, Kahne D, Walker S, Marks DS, Bernhardt TG, Rudner DZ, Kruse AC
Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope.
1. Nat Commun - published March 2, 2018
2. Barnes CO, Gristick HB, Freund NT, Escolano A, Lyubimov AY, Hartweger H, West AP Jr., Cohen AE, Nussenzweig MC, Bjorkman PJ
Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage.
1. Elife - published March 2, 2018
2. Wendorff TJ, Berger JM
A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel.
1. Structure - published March 2, 2018
2. Johnson CN, Potet F, Thompson MK, Kroncke BM, Glazer AM, Voehler MW, Knollmann BC, George AL Jr., Chazin WJ
A Small-Molecule CD4-mimetic Compound Protects BLT Humanized Mice from Human Immunodeficiency Virus Infection.
1. J Infect Dis - published March 2, 2018
2. Princiotto AM, Vrbanac VD, Melillo B, Park J, Tager AM, Smith AB 3rd, Sodroski J, Madani N
Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity.
1. Bioorg Med Chem Lett - published March 2, 2018
2. May-Dracka TL, Arduini R, Bertolotti-Ciarlet A, Bhisetti G, Brickelmaier M, Cahir-McFarland E, Enyedy I, Fontenot JD, Hesson T, Little K, Lyssikatos J, Marcotte D, McKee T, Murugan P, Patterson T, Peng H, Rushe M, Silvian L, Spilker K, Wu P, Xin Z, Burkly LC
The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5α.
1. J Virol - published March 1, 2018
2. Morger D, Zosel F, Bühlmann M, Züger S, Mittelviefhaus M, Schuler B, Luban J, Grütter MG
Cryo-Electron Microscopy Structure of Seneca Valley Virus Procapsid.
1. J Virol - published March 1, 2018
2. Strauss M, Jayawardena N, Sun E, Easingwood RA, Burga LN, Bostina M
Evaluation of β-Amino Acid Replacements in Protein Loops: Effects on Conformational Stability and Structure.
1. Chembiochem - published March 1, 2018
2. Mortenson DE, Kreitler DF, Thomas NC, Guzei IA, Gellman SH, Forest KT
Influence of hydrocarbon-stapling on membrane interactions of synthetic antimicrobial peptides.
1. Bioorg Med Chem - published March 1, 2018
2. Stone TA, Cole GB, Nguyen HQ, Sharpe S, Deber CM
Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine-based inhibitor co-crystal structure.
1. Protein Sci - published March 1, 2018
2. Marcotte DJ, Hus JC, Banos CC, Wildes C, Arduini R, Bergeron C, Hession CA, Baker DP, Lin E, Guckian KM, Dunah AW, Silvian LF
PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors.
1. Clin Cancer Res - published March 1, 2018
2. Croessmann S, Sheehan JH, Lee KM, Sliwoski G, He J, Nagy R, Riddle D, Mayer IA, Balko JM, Lanman R, Miller VA, Cantley LC, Meiler J, Arteaga CL
The elongation factor Spn1 is a multi-functional chromatin binding protein.
1. Nucleic Acids Res - published March 1, 2018
2. Li S, Almeida AR, Radebaugh CA, Zhang L, Chen X, Huang L, Thurston AK, Kalashnikova AA, Hansen JC, Luger K, Stargell LA
Affinity maturation of a portable Fab-RNA module for chaperone-assisted RNA crystallography.
1. Nucleic Acids Res - published March 1, 2018
2. Koirala D, Shelke SA, Dupont M, Ruiz S, DasGupta S, Bailey LJ, Benner SA, Piccirilli JA
Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer.
1. Clin Cancer Res - published March 1, 2018
2. Thangavel C, Boopathi E, Liu Y, McNair C, Haber A, Perepelyuk M, Bhardwaj A, Addya S, Ertel A, Shoyele S, Birbe R, Salvino JM, Dicker AP, Knudsen KE, Den RB
The role of Ala134 in controlling substrate binding and reactivity in ascorbate peroxidase.
1. J Inorg Biochem - published March 1, 2018
2. Turner DD, Lad L, Kwon H, Basran J, Carr KH, Moody PCE, Raven EL
The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
1. Nat Chem Biol - published March 1, 2018
2. Joedicke L, Mao J, Kuenze G, Reinhart C, Kalavacherla T, Jonker HRA, Richter C, Schwalbe H, Meiler J, Preu J, Michel H, Glaubitz C
Constitutive centromere-associated network contacts confer differential stability on CENP-A nucleosomes in vitro and in the cell.
1. Mol Biol Cell - published March 1, 2018
2. Cao S, Zhou K, Zhang Z, Luger K, Straight AF
Cytoskeleton in high resolution.
1. Nat Rev Mol Cell Biol - published March 1, 2018
2. Nogales E
Burden of cardiovascular disease across 29 countries and GPs' decision to treat hypertension in oldest-old.
1. Scand J Prim Health Care - published March 1, 2018
2. Streit S, Gussekloo J, Burman RA, Collins C, Kitanovska BG, Gintere S, Gómez Bravo R, Hoffmann K, Iftode C, Johansen KL, Kerse N, Koskela TH, Peštić SK, Kurpas D, Mallen CD, Maisonneuve H, Merlo C, Mueller Y, Muth C, Ornelas RH, Šter MP, Petrazzuoli F, Rosemann T, Sattler M, Švadlenková Z, Tatsioni A, Thulesius H, Tkachenko V, Torzsa P, Tsopra R, Tuz C, Verschoor M, Viegas RPA, Vinker S, de Waal MWM, Zeller A, Rodondi N, Poortvliet RKE
Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform.
1. J Biol Chem - published March 1, 2018
2. Shumar SA, Kerr EW, Geldenhuys WJ, Montgomery GE, Fagone P, Thirawatananond P, Saavedra H, Gabelli SB, Leonardi R
Sequence-specific DNA binding activity of the cross-brace zinc finger motif of the piggyBac transposase.
1. Nucleic Acids Res - published March 1, 2018
2. Morellet N, Li X, Wieninger SA, Taylor JL, Bischerour J, Moriau S, Lescop E, Bardiaux B, Mathy N, Assrir N, Bétermier M, Nilges M, Hickman AB, Dyda F, Craig NL, Guittet E
How Detergent Impacts Membrane Proteins: Atomic-Level Views of Mitochondrial Carriers in Dodecylphosphocholine.
1. J Phys Chem Lett - published March 1, 2018
2. Kurauskas V, Hessel A, Ma P, Lunetti P, Weinhäupl K, Imbert L, Brutscher B, King MS, Sounier R, Dolce V, Kunji ERS, Capobianco L, Chipot C, Dehez F, Bersch B, Schanda P
Yeast surface display platform for rapid discovery of conformationally selective nanobodies.
1. Nat Struct Mol Biol - published March 1, 2018
2. McMahon C, Baier AS, Pascolutti R, Wegrecki M, Zheng S, Ong JX, Erlandson SC, Hilger D, Rasmussen SGF, Ring AM, Manglik A, Kruse AC
Comprehensive Analysis of Constraint on the Spatial Distribution of Missense Variants in Human Protein Structures.
1. Am J Hum Genet - published March 1, 2018
2. Sivley RM, Dou X, Meiler J, Bush WS, Capra JA
Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by Nuclear Magnetic Resonance.
1. Biochemistry - published March 1, 2018
2. Khan SN, Persons JD, Paulsen JL, Guerrero M, Schiffer CA, Kurt-Yilmaz N, Ishima R
Molecular basis for sterol transport by StART-like lipid transfer domains.
1. EMBO J - published March 1, 2018
2. Horenkamp FA, Valverde DP, Nunnari J, Reinisch KM
Alternative Metrics of Scholarly Output: The Relationship among Altmetric Score, Mendeley Reader Score, Citations, and Downloads in Plastic and Reconstructive Surgery.
1. Plast Reconstr Surg - published March 1, 2018
2. Ruan QZ, Chen AD, Cohen JB, Singhal D, Lin SJ, Lee BT
Real-space analysis of radiation-induced specific changes with independent component analysis.
1. J Synchrotron Radiat - published March 1, 2018
2. Borek D, Bromberg R, Hattne J, Otwinowski Z
The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes: A Decade of Structures Unraveling the Mechanics of the Process.
1. Annu Rev Biophys - published March 1, 2018
2. Hashem Y, Frank J
Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding.
1. Mol Cell - published March 1, 2018
2. Chen S, Jiao L, Shubbar M, Yang X, Liu X
Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells.
1. Cell Res - published March 1, 2018
2. Qi C, Wang X, Shen Z, Chen S, Yu H, Williams N, Wang G
Structural Basis for NusA Stabilized Transcriptional Pausing.
1. Mol Cell - published March 1, 2018
2. Guo X, Myasnikov AG, Chen J, Crucifix C, Papai G, Takacs M, Schultz P, Weixlbaumer A
LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens.
1. J Biol Chem - published March 1, 2018
2. Yokoyama CC, Baldridge MT, Leung DW, Zhao G, Desai C, Liu TC, Diaz-Ochoa VE, Huynh JP, Kimmey JM, Sennott EL, Hole CR, Idol RA, Park S, Storek KM, Wang C, Hwang S, Milam AV, Chen E, Kerrinnes T, Starnbach MN, Handley SA, Mysorekar IU, Allen PM, Monack DM, Dinauer MC, Doering TL, Tsolis RM, Dworkin JE, Stallings CL, Amarasinghe GK, Micchelli CA, Virgin HW
RNA Polymerase Accommodates a Pause RNA Hairpin by Global Conformational Rearrangements that Prolong Pausing.
1. Mol Cell - published March 1, 2018
2. Kang JY, Mishanina TV, Bellecourt MJ, Mooney RA, Darst SA, Landick R
Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD.
1. Mol Cell - published March 1, 2018
2. Escudero S, Zaganjor E, Lee S, Mill CP, Morgan AM, Crawford EB, Chen J, Wales TE, Mourtada R, Luccarelli J, Bird GH, Steidl U, Engen JR, Haigis MC, Opferman JT, Walensky LD
FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.
1. Mol Cell - published March 1, 2018
2. Zhang T, Wu YC, Mullane P, Ji YJ, Liu H, He L, Arora A, Hwang HY, Alessi AF, Niaki AG, Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, Myong S, Kim JK, Shorter J, Ong SE, Leung AKL, Wang J
Theories for Sequence-Dependent Phase Behaviors of Biomolecular Condensates.
1. Biochemistry - published March 1, 2018
2. Lin YH, Forman-Kay JD, Chan HS
Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor.
1. PLoS Pathog - published March 1, 2018
2. Stichling N, Suomalainen M, Flatt JW, Schmid M, Pacesa M, Hemmi S, Jungraithmayr W, Maler MD, Freudenberg MA, Plückthun A, May T, Köster M, Fejer G, Greber UF
Electrophoretic Mechanism of Au25(SR)18 Heating in Radiofrequency Fields.
1. J Phys Chem Lett - published March 1, 2018
2. Collins CB, Tofanelli MA, Noblitt SD, Ackerson CJ
Molecular Basis for the Attachment of S-Layer Proteins to the Cell Wall of Bacillus anthracis.
1. Biochemistry - published March 1, 2018
2. Sychantha D, Chapman RN, Bamford NC, Boons GJ, Howell PL, Clarke AJ
Redesign of LAOBP to bind novel L-amino acid ligands.
1. Protein Sci - published March 1, 2018
2. Banda-Vázquez J, Shanmugaratnam S, Rodríguez-Sotres R, Torres-Larios A, Höcker B, Sosa-Peinado A
Programmable RNA recognition using a CRISPR-associated Argonaute.
1. Proc Natl Acad Sci U S A - published March 1, 2018
2. Lapinaite A, Doudna JA, Cate JHD
Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations.
1. Sci Adv - published March 1, 2018
2. Huang H, Kuenze G, Smith JA, Taylor KC, Duran AM, Hadziselimovic A, Meiler J, Vanoye CG, George AL Jr, Sanders CR
Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2.
1. Nat Struct Mol Biol - published March 1, 2018
2. Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS
Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis.
1. Nat Chem Biol - published March 1, 2018
2. Newmister SA, Li S, Garcia-Borràs M, Sanders JN, Yang S, Lowell AN, Yu F, Smith JL, Williams RM, Houk KN, Sherman DH
Gene network analysis identifies a central post-transcriptional regulator of cellular stress survival.
1. Elife - published March 1, 2018
2. Tien M, Fiebig A, Crosson S
Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression.
1. Nat Commun - published March 1, 2018
2. Zhang L, Zhou H, Li X, Vartuli RL, Rowse M, Xing Y, Rudra P, Ghosh D, Zhao R, Ford HL
Accurate PDZ/Peptide Binding Specificity with Additive and Polarizable Free Energy Simulations.
1. Biophys J - published March 1, 2018
2. Panel N, Villa F, Fuentes EJ, Simonson T
The choroid plexus is an important circadian clock component.
1. Nat Commun - published March 1, 2018
2. Myung J, Schmal C, Hong S, Tsukizawa Y, Rose P, Zhang Y, Holtzman MJ, De Schutter E, Herzel H, Bordyugov G, Takumi T
Zinc knuckle of TAF1 is a DNA binding module critical for TFIID promoter occupancy.
1. Sci Rep - published March 1, 2018
2. Curran EC, Wang H, Hinds TR, Zheng N, Wang EH
Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen.
1. Elife - published March 1, 2018
2. Shah NH, Löbel M, Weiss A, Kuriyan J
HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope.
1. Nat Commun - published March 1, 2018
2. Fera D, Lee MS, Wiehe K, Meyerhoff RR, Piai A, Bonsignori M, Aussedat B, Walkowicz WE, Ton T, Zhou JO, Danishefsky S, Haynes BF, Harrison SC
Blind estimation of DED camera gain in Electron Microscopy.
1. J Struct Biol - published March 1, 2018
2. Sorzano COS, Fernández-Giménez E, Peredo-Robinson V, Vargas J, Majtner T, Caffarena G, Otón J, Vilas JL, de la Rosa-Trevín JM, Melero R, Gómez-Blanco J, Cuenca J, Del Cano L, Conesa P, Marabini R, Carazo JM
A High Content Screen in Macrophages Identifies Small Molecule Modulators of STING-IRF3 and NFkB Signaling.
1. ACS Chem Biol - published March 1, 2018
2. Koch PD, Miller HR, Yu G, Tallarico JA, Sorger PK, Wang Y, Feng Y, Thomas JR, Ross NT, Mitchison T
Activity and fidelity of human DNA polymerase α depend on primer structure.
1. J Biol Chem - published March 1, 2018
2. Baranovskiy AG, Duong VN, Babayeva ND, Zhang Y, Pavlov YI, Anderson KS, Tahirov TH
Structural basis for backbone N-methylation by an interrupted adenylation domain.
1. Nat Chem Biol - published March 1, 2018
2. Mori S, Pang AH, Lundy TA, Garzan A, Tsodikov OV, Garneau-Tsodikova S
Acute vitreoretinal trauma and inflammation after traumatic brain injury in mice.
1. Ann Clin Transl Neurol - published March 1, 2018
2. Evans LP, Newell EA, Mahajan M, Tsang SH, Ferguson PJ, Mahoney J, Hue CD, Vogel EW 3rd, Morrison B 3rd, Arancio O, Nichols R, Bassuk AG, Mahajan VB
Structural basis for LeishIF4E-1 modulation by an interacting protein in the human parasite Leishmania major.
1. Nucleic Acids Res - published March 1, 2018
2. Meleppattu S, Arthanari H, Zinoviev A, Boeszoermenyi A, Wagner G, Shapira M, Léger-Abraham M
A mass spectrometry based transport assay for studying EmrE transport of unlabeled substrates.
1. Anal Biochem - published March 1, 2018
2. Robinson AE, Henderson JP, Henzler-Wildman KA
Cryo-EM structure of the nucleosome containing the ALB1 enhancer DNA sequence.
1. Open Biol - published March 1, 2018
2. Takizawa Y, Tanaka H, Machida S, Koyama M, Maehara K, Ohkawa Y, Wade PA, Wolf M, Kurumizaka H
Non-eluting, surface-bound enzymes disrupt surface attachment of bacteria by continuous biofilm polysaccharide degradation.
1. Biomaterials - published March 1, 2018
2. Asker D, Awad TS, Baker P, Howell PL, Hatton BD
Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis.
1. Science - published March 1, 2018
2. Dong M, Kathiresan V, Fenwick MK, Torelli AT, Zhang Y, Caranto JD, Dzikovski B, Sharma A, Lancaster KM, Freed JH, Ealick SE, Hoffman BM, Lin H
The National Surgical Quality Improvement Program 30-Day Challenge: Microsurgical Breast Reconstruction Outcomes Reporting Reliability.
1. Plast Reconstr Surg Glob Open - published March 1, 2018
2. Chen AD, Kamali P, Chattha AS, Bucknor A, Cohen JB, Bletsis PP, Flecha-Hirsch R, Tobias AM, Lee BT, Lin SJ
A new MR-SAD algorithm for the automatic building of protein models from low-resolution X-ray data and a poor starting model.
1. IUCrJ - published March 1, 2018
2. Skubák P, Araç D, Bowler MW, Correia AR, Hoelz A, Larsen S, Leonard GA, McCarthy AA, McSweeney S, Mueller-Dieckmann C, Otten H, Salzman G, Pannu NS
From electron crystallography of 2D crystals to MicroED of 3D crystals.
1. Curr Opin Colloid Interface Sci - published March 1, 2018
2. Martynowycz MW, Gonen T