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130 Member Publications for April 2016

Structural and Mechanistic Insights into the Tropism of Epstein-Barr Virus.
1. Mol. Cells - published April 30, 2016
2. Möhl BS, Chen J, Sathiyamoorthy K, Jardetzky TS, Longnecker R
RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment.
1. J. Biol. Chem. - published April 29, 2016
2. Hodge CD, Ismail IH, Edwards RA, Hura GL, Xiao AT, Tainer JA, Hendzel MJ, Glover JN
Substoichiometric inhibition of transthyretin misfolding by immune-targeting sparsely populated misfolding intermediates: a potential diagnostic and therapeutic for TTR amyloidoses.
1. Sci Rep - published April 29, 2016
2. Galant NJ, Bugyei-Twum A, Rakhit R, Walsh P, Sharpe S, Arslan PE, Westermark P, Higaki JN, Torres R, Tapia J, Chakrabartty A
Drosha and Dicer: Slicers cut from the same cloth.
1. Cell Res. - published April 29, 2016
2. Li S, Patel DJ
Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes.
1. Development - published April 29, 2016
2. Burger A, Lindsay H, Felker A, Hess C, Anders C, Chiavacci E, Zaugg J, Weber LM, Catena R, Jinek M, Robinson MD, Mosimann C
Enhanced lysis by bispecific oncolytic measles viruses simultaneously using HER2/neu or EpCAM as target receptors.
1. Mol Ther Oncolytics - published April 28, 2016
2. Hanauer JR, Gottschlich L, Riehl D, Rusch T, Koch V, Friedrich K, Hutzler S, Prüfer S, Friedel T, Hanschmann KM, Münch RC, Jost C, Plückthun A, Cichutek K, Buchholz CJ, Mühlebach MD
Nucleosome breathing and remodeling constrain CRISPR-Cas9 function.
1. Elife - published April 28, 2016
2. Isaac RS, Jiang F, Doudna JA, Lim WA, Narlikar GJ, Almeida R
The structure and function of glutamate receptors: Mg(2+) block to X-ray diffraction.
1. Neuropharmacology - published April 27, 2016
2. Mayer ML
Automated structure modeling of large protein assemblies using crosslinks as distance restraints.
1. Nat. Methods - published April 26, 2016
2. Ferber M, Kosinski J, Ori A, Rashid UJ, Moreno-Morcillo M, Simon B, Bouvier G, Batista PR, Müller CW, Beck M, Nilges M
A novel flagellar sheath protein, FcpA, determines filament coiling, translational motility and virulence for the Leptospira spirochete.
1. Mol. Microbiol. - published April 26, 2016
2. Wunder EA, Figueira CP, Benaroudj N, Hu B, Tong BA, Trajtenberg F, Liu J, Reis MG, Charon NW, Buschiazzo A, Picardeau M, Ko AI
StructMap: Elastic Distance Analysis of Electron Microscopy Maps for Studying Conformational Changes.
1. Biophys. J. - published April 26, 2016
2. Sanchez Sorzano CO, Alvarez-Cabrera AL, Kazemi M, Carazo JM, Jonić S
Preparing Samples for Crystallization of Bcl-2 Family Complexes.
1. Methods Mol. Biol. - published April 25, 2016
2. Kvansakul M, Czabotar PE
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
1. Nat. Chem. Biol. - published April 25, 2016
2. Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM
Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting.
1. Elife - published April 25, 2016
2. Mavor D, Barlow K, Thompson S, Barad BA, Bonny AR, Cario CL, Gaskins G, Liu Z, Deming L, Axen SD, Caceres E, Chen W, Cuesta A, Gate RE, Green EM, Hulce KR, Ji W, Kenner LR, Mensa B, Morinishi LS, Moss SM, Mravic M, Muir RK, Niekamp S, Nnadi CI, Palovcak E, Poss EM, Ross TD, Salcedo EC, See SK, Subramaniam M, Wong AW, Li J, Thorn KS, Conchúir SÓ, Roscoe BP, Chow ED, DeRisi JL, Kortemme T, Bolon DN, Fraser JS
Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.
1. Proc. Natl. Acad. Sci. U.S.A. - published April 25, 2016
2. Volpon L, Culjkovic-Kraljacic B, Osborne MJ, Ramteke A, Sun Q, Niesman A, Chook YM, Borden KL
DARPin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography.
1. J. Mol. Biol. - published April 24, 2016
2. Batyuk A, Wu Y, Honegger A, Heberling MM, Plückthun A
Structural and Molecular Determinants of Membrane Binding by the HIV-1 Matrix Protein.
1. J. Mol. Biol. - published April 24, 2016
2. Mercredi PY, Bucca N, Loeliger B, Gaines CR, Mehta M, Bhargava P, Tedbury PR, Charlier L, Floquet N, Muriaux D, Favard C, Sanders CR, Freed EO, Marchant J, Summers MF
Local analysis of strains and rotations for macromolecular electron microscopy maps.
1. J. Struct. Biol. - published April 23, 2016
2. Sorzano CO, Martín-Ramos A, Prieto F, Melero R, Martín-Benito J, Jonic S, Navas-Calvente J, Vargas J, Otón J, Abrishami V, de la Rosa-Trevín JM, Gómez-Blanco J, Vilas JL, Marabini R, Carazo JM
Carbon-sulfur bond-forming reaction catalysed by the radical SAM enzyme HydE.
1. Nat Chem - published April 23, 2016
2. Rohac R, Amara P, Benjdia A, Martin L, Ruffié P, Favier A, Berteau O, Mouesca JM, Fontecilla-Camps JC, Nicolet Y
Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococcal Virulence Factor NadA.
1. PLoS Pathog. - published April 23, 2016
2. Liguori A, Malito E, Lo Surdo P, Fagnocchi L, Cantini F, Haag AF, Brier S, Pizza M, Delany I, Bottomley MJ
Perchlorate Reductase Is Distinguished by Active Site Aromatic Gate Residues.
1. J. Biol. Chem. - published April 22, 2016
2. Youngblut MD, Tsai CL, Clark IC, Carlson HK, Maglaqui AP, Gau-Pan PS, Redford SA, Wong A, Tainer JA, Coates JD
RNA polymerase II acts as a selective sensor for DNA lesions and endogenous DNA modifications.
1. Transcription - published April 22, 2016
2. Shin JH, Xu L, Wang D
Toward correlating structure and mechanics of platelets.
1. Cell Adh Migr - published April 22, 2016
2. Sorrentino S, Studt JD, Horev MB, Medalia O, Sapra KT
Mechanistic Approach to Understanding the Influence of USP Apparatus I and II on Dissolution Kinetics of Tablets with Different Operating Release Mechanisms.
1. AAPS PharmSciTech - published April 22, 2016
2. Lu Z, Fassihi R
Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics.
1. Mol. Cell - published April 21, 2016
2. Ouyang Z, Zheng G, Tomchick DR, Luo X, Yu H
Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5.
1. Sci Rep - published April 21, 2016
2. Swale C, Monod A, Tengo L, Labaronne A, Garzoni F, Bourhis JM, Cusack S, Schoehn G, Berger I, Ruigrok RW, Crépin T
Rosetta and the Design of Ligand Binding Sites.
1. Methods Mol. Biol. - published April 21, 2016
2. Moretti R, Bender BJ, Allison B, Meiler J
Molecular structural analysis of a novel and de-novo mutation in the SERPINC1 gene associated with type 1 antithrombin deficiency.
1. Br. J. Haematol. - published April 21, 2016
2. Wang TF, Dawson JE, Forman-Kay JD, Kahr WH, Williams S, Chan AK, Kumar R
Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters.
1. Mol. Cell - published April 21, 2016
2. Goudarzi A, Zhang D, Huang H, Barral S, Kwon OK, Qi S, Tang Z, Buchou T, Vitte AL, He T, Cheng Z, Montellier E, Gaucher J, Curtet S, Debernardi A, Charbonnier G, Puthier D, Petosa C, Panne D, Rousseaux S, Roeder RG, Zhao Y, Khochbin S
EGFR fusions as novel therapeutic targets in lung cancer.
1. Cancer Discov - published April 21, 2016
2. Konduri K, Gallant JN, Chae YK, Giles FJ, Gitlitz BJ, Gowen K, Ichihara E, Owonikoko TK, Peddareddigari V, Ramalingam SS, Reddy SK, Eaby-Sandy B, Vavalà T, Whiteley A, Chen H, Yan Y, Sheehan JH, Meiler J, Morosini D, Ross JS, Stephens PJ, Miller VA, Ali SM, Lovly CM
Screening Glycolipids Against Proteins in Vitro Using Picodiscs and Catch-and-Release Electrospray Ionization-Mass Spectrometry.
1. Anal. Chem. - published April 20, 2016
2. Li J, Fan X, Kitova EN, Zou C, Cairo CW, Eugenio L, Ng KK, Xiong ZJ, Privé GG, Klassen JS
Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue.
1. Nat Commun - published April 20, 2016
2. Da LT, Pardo-Avila F, Xu L, Silva DA, Zhang L, Gao X, Wang D, Huang X
Improving Viral Protease Inhibitors to Counter Drug Resistance.
1. Trends Microbiol. - published April 20, 2016
2. Kurt Yilmaz N, Swanstrom R, Schiffer CA
Strange kinetics of bulk-mediated diffusion on lipid bilayers.
1. Phys Chem Chem Phys - published April 20, 2016
2. Krapf D, Campagnola G, Nepal K, Peersen OB
Synthesis of Water-Soluble, Thiolate-Protected Gold Nanoparticles Uniform in Size.
1. Nano Lett. - published April 19, 2016
2. Azubel M, Kornberg RD
The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy.
1. Nat Commun - published April 19, 2016
2. Lukey MJ, Greene KS, Erickson JW, Wilson KF, Cerione RA
Denoising of high-resolution single-particle electron-microscopy density maps by their approximation using three-dimensional Gaussian functions.
1. J. Struct. Biol. - published April 18, 2016
2. Jonić S, Vargas J, Melero R, Gómez-Blanco J, Carazo JM, Sorzano CO
Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice.
1. Nat. Med. - published April 18, 2016
2. Choi VM, Herrou J, Hecht AL, Teoh WP, Turner JR, Crosson S, Bubeck Wardenburg J
The Substrate Specificity of Sirtuins.
1. Annu. Rev. Biochem. - published April 18, 2016
2. Bheda P, Jing H, Wolberger C, Lin H
Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels.
1. Proc. Natl. Acad. Sci. U.S.A. - published April 18, 2016
2. Su Z, Brown EC, Wang W, MacKinnon R
Durable antitumor responses to CD47 blockade require adaptive immune stimulation.
1. Proc. Natl. Acad. Sci. U.S.A. - published April 18, 2016
2. Sockolosky JT, Dougan M, Ingram JR, Ho CC, Kauke MJ, Almo SC, Ploegh HL, Garcia KC
Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172.
1. ACS Chem. Biol. - published April 15, 2016
2. Soumana DI, Kurt Yilmaz N, Prachanronarong KL, Aydin C, Ali A, Schiffer CA
Bromodomains: Structure, function and pharmacology of inhibition.
1. Biochem. Pharmacol. - published April 15, 2016
2. Ferri E, Petosa C, McKenna CE
Molecular basis of ion permeability in a voltage-gated sodium channel.
1. EMBO J. - published April 15, 2016
2. Naylor CE, Bagnéris C, DeCaen PG, Sula A, Scaglione A, Clapham DE, Wallace BA
The collection of MicroED data for macromolecular crystallography.
1. Nat Protoc - published April 15, 2016
2. Shi D, Nannenga BL, de la Cruz MJ, Liu J, Sawtelle S, Calero G, Reyes FE, Hattne J, Gonen T
Initiation of RNA Polymerization and Polymerase Encapsidation by a Small dsRNA Virus.
1. PLoS Pathog. - published April 15, 2016
2. Collier AM, Lyytinen OL, Guo YR, Toh Y, Poranen MM, Tao YJ
Architecture of the symmetric core of the nuclear pore.
1. Science - published April 15, 2016
2. Lin DH, Stuwe T, Schilbach S, Rundlet EJ, Perriches T, Mobbs G, Fan Y, Thierbach K, Huber FM, Collins LN, Davenport AM, Jeon YE, Hoelz A
Molecular architecture of the inner ring scaffold of the human nuclear pore complex.
1. Science - published April 15, 2016
2. Kosinski J, Mosalaganti S, von Appen A, Teimer R, DiGuilio AL, Wan W, Bui KH, Hagen WJ, Briggs JA, Glavy JS, Hurt E, Beck M
Metabolic Requirements of Escherichia coli in Intracellular Bacterial Communities during Urinary Tract Infection Pathogenesis.
1. MBio - published April 14, 2016
2. Conover MS, Hadjifrangiskou M, Palermo JJ, Hibbing ME, Dodson KW, Hultgren SJ
Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus.
1. Org. Lett. - published April 14, 2016
2. Wan LS, Nian Y, Ye CJ, Shao LD, Peng XR, Geng CA, Zuo ZL, Li XN, Yang J, Zhou M, Qiu MH
Three stories on Eph kinase inhibitors: From in silico discovery to in vivo validation.
1. Eur J Med Chem - published April 13, 2016
2. Unzue A, Lafleur K, Zhao H, Zhou T, Dong J, Kolb P, Liebl J, Zahler S, Caflisch A, Nevado C
The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers.
1. Elife - published April 13, 2016
2. Touhara KK, Wang W, MacKinnon R
Cooperative regulation by G proteins and Na(+) of neuronal GIRK2 K(+) channels.
1. Elife - published April 13, 2016
2. Wang W, Touhara KK, Weir K, Bean BP, MacKinnon R
Cooperative folding near the downhill limit determined with amino acid resolution by hydrogen exchange.
1. Proc. Natl. Acad. Sci. U.S.A. - published April 13, 2016
2. Yu W, Baxa MC, Gagnon I, Freed KF, Sosnick TR
Survival kinase genes present prognostic significance in glioblastoma.
1. Oncotarget - published April 12, 2016
2. Varghese RT, Liang Y, Guan T, Franck CT, Kelly DF, Sheng Z
Measuring and modeling diffuse scattering in protein X-ray crystallography.
1. Proc. Natl. Acad. Sci. U.S.A. - published April 12, 2016
2. Van Benschoten AH, Liu L, Gonzalez A, Brewster AS, Sauter NK, Fraser JS, Wall ME
A bacterial Argonaute with noncanonical guide RNA specificity.
1. Proc. Natl. Acad. Sci. U.S.A. - published April 12, 2016
2. Kaya E, Doxzen KW, Knoll KR, Wilson RC, Strutt SC, Kranzusch PJ, Doudna JA
Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability.
1. PLoS Pathog. - published April 12, 2016
2. Mason RD, Welles HC, Adams C, Chakrabarti BK, Gorman J, Zhou T, Nguyen R, O'Dell S, Lusvarghi S, Bewley CA, Li H, Shaw GM, Sheng Z, Shapiro L, Wyatt R, Kwong PD, Mascola JR, Roederer M
Novel mutations highlight the key role of the ankyrin repeat domain in TRPV4-mediated neuropathy.
1. Neurol Genet - published April 12, 2016
2. Sullivan JM, Zimanyi CM, Aisenberg W, Bears B, Chen DH, Day JW, Bird TD, Siskind CE, Gaudet R, Sumner CJ
Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.
1. Biochemistry - published April 11, 2016
2. LaRochelle JR, Fodor M, Xu X, Durzynska I, Fan L, Stams T, Chan HM, LaMarche MJ, Chopra R, Wang P, Fortin PD, Acker MG, Blacklow SC
Control of plasma membrane lipid homeostasis by the extended synaptotagmins.
1. Nat. Cell Biol. - published April 11, 2016
2. Saheki Y, Bian X, Schauder CM, Sawaki Y, Surma MA, Klose C, Pincet F, Reinisch KM, De Camilli P
Direct Demonstration that Loop1 of Scap Binds to Loop7, a crucial event in cholesterol homeostasis.
1. J. Biol. Chem. - published April 11, 2016
2. Zhang Y, Lee KM, Kinch LN, Clark L, Grishin NV, Rosenbaum DM, Brown MS, Goldstein JL, Radhakrishnan A
Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity.
1. Proc. Natl. Acad. Sci. U.S.A. - published April 11, 2016
2. Markovski M, Bohrhunter JL, Lupoli TJ, Uehara T, Walker S, Kahne DE, Bernhardt TG
Deletion Mutations Keep Kinase Inhibitors in the Loop.
1. Cancer Cell - published April 11, 2016
2. Freed DM, Park JH, Radhakrishnan R, Lemmon MA
Transcribing RNA polymerase III observed by electron cryomicroscopy.
1. FEBS J. - published April 10, 2016
2. Hoffmann NA, Jakobi AJ, Vorländer MK, Sachse C, Müller CW
Crystal structure of the flagellar accessory protein FlaH of Methanocaldococcus jannaschii suggests a regulatory role in archaeal flagellum assembly.
1. Protein Sci. - published April 10, 2016
2. Meshcheryakov VA, Wolf M
Transthyretin Suppresses Amyloid-β Secretion by Interfering with Processing of the Amyloid-β Protein Precursor.
1. J. Alzheimers Dis. - published April 8, 2016
2. Li X, Song Y, Sanders CR, Buxbaum JN
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.
1. Science - published April 8, 2016
2. Tirosh I, Izar B, Prakadan SM, Wadsworth MH, Treacy D, Trombetta JJ, Rotem A, Rodman C, Lian C, Murphy G, Fallahi-Sichani M, Dutton-Regester K, Lin JR, Cohen O, Shah P, Lu D, Genshaft AS, Hughes TK, Ziegler CG, Kazer SW, Gaillard A, Kolb KE, Villani AC, Johannessen CM, Andreev AY, Van Allen EM, Bertagnolli M, Sorger PK, Sullivan RJ, Flaherty KT, Frederick DT, Jané-Valbuena J, Yoon CH, Rozenblatt-Rosen O, Shalek AK, Regev A, Garraway LA
Chemo-enzymatic synthesis of site-specific isotopically labeled nucleotides for use in NMR resonance assignment, dynamics and structural characterizations.
1. Nucleic Acids Res. - published April 7, 2016
2. Longhini AP, LeBlanc RM, Becette O, Salguero C, Wunderlich CH, Johnson BA, D'Souza VM, Kreutz C, Dayie TK
The Coding Region of the HCV Genome Contains a Network of Regulatory RNA Structures.
1. Mol. Cell - published April 7, 2016
2. Pirakitikulr N, Kohlway A, Lindenbach BD, Pyle AM
Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.
1. Cell - published April 7, 2016
2. Bonsignori M, Zhou T, Sheng Z, Chen L, Gao F, Joyce MG, Ozorowski G, Chuang GY, Schramm CA, Wiehe K, Alam SM, Bradley T, Gladden MA, Hwang KK, Iyengar S, Kumar A, Lu X, Luo K, Mangiapani MC, Parks RJ, Song H, Acharya P, Bailer RT, Cao A, Druz A, Georgiev IS, Kwon YD, Louder MK, Zhang B, Zheng A, Hill BJ, Kong R, Soto C, NISC Comparative Sequencing Program, Mullikin JC, Douek DC, Montefiori DC, Moody MA, Shaw GM, Hahn BH, Kelsoe G, Hraber PT, Korber BT, Boyd SD, Fire AZ, Kepler TB, Shapiro L, Ward AB, Mascola JR, Liao HX, Kwong PD, Haynes BF
Programmable RNA Tracking in Live Cells with CRISPR/Cas9.
1. Cell - published April 7, 2016
2. Nelles DA, Fang MY, O'Connell MR, Xu JL, Markmiller SJ, Doudna JA, Yeo GW
Potent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosis.
1. ACS Chem. Biol. - published April 7, 2016
2. Willby MJ, Green KD, Gajadeera CS, Hou C, Tsodikov OV, Posey JE, Garneau-Tsodikova S
Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration.
1. Cell Stem Cell - published April 7, 2016
2. Sun X, Chuang JC, Kanchwala M, Wu L, Celen C, Li L, Liang H, Zhang S, Maples T, Nguyen LH, Wang SC, Signer RA, Sorouri M, Nassour I, Liu X, Xu J, Wu M, Zhao Y, Kuo YC, Wang Z, Xing C, Zhu H
Deacetylation of Fungal Exopolysaccharide Mediates Adhesion and Biofilm Formation.
1. MBio - published April 7, 2016
2. Lee MJ, Geller AM, Bamford NC, Liu H, Gravelat FN, Snarr BD, Le Mauff F, Chabot J, Ralph B, Ostapska H, Lehoux M, Cerone RP, Baptista SD, Vinogradov E, Stajich JE, Filler SG, Howell PL, Sheppard DC
Diffraction-geometry refinement in the DIALS framework.
1. Acta Crystallogr D Struct Biol - published April 7, 2016
2. Waterman DG, Winter G, Gildea RJ, Parkhurst JM, Brewster AS, Sauter NK, Evans G
SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins.
1. Mol. Cell - published April 7, 2016
2. Park MJ, Sheng R, Silkov A, Jung DJ, Wang ZG, Xin Y, Kim H, Thiagarajan-Rosenkranz P, Song S, Yoon Y, Nam W, Kim I, Kim E, Lee DG, Chen Y, Singaram I, Wang L, Jang MH, Hwang CS, Honig B, Ryu S, Lorieau J, Kim YM, Cho W
CSR-1 Slices a Balance.
1. Cell - published April 7, 2016
2. Yu R, Moazed D
Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis.
1. Cell Stem Cell - published April 7, 2016
2. Westphalen CB, Takemoto Y, Tanaka T, Macchini M, Jiang Z, Renz BW, Chen X, Ormanns S, Nagar K, Tailor Y, May R, Cho Y, Asfaha S, Worthley DL, Hayakawa Y, Urbanska AM, Quante M, Reichert M, Broyde J, Subramaniam PS, Remotti H, Su GH, Rustgi AK, Friedman RA, Honig B, Califano A, Houchen CW, Olive KP, Wang TC
Phase separation of signaling molecules promotes T cell receptor signal transduction.
1. Science - published April 7, 2016
2. Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD
Clostridium difficile infection.
1. Nat Rev Dis Primers - published April 7, 2016
2. Smits WK, Lyras D, Lacy DB, Wilcox MH, Kuijper EJ
CASP11 - An Evaluation of a Modular BCL::Fold-Based Protein Structure Prediction Pipeline.
1. PLoS ONE - published April 6, 2016
2. Fischer AW, Heinze S, Putnam DK, Li B, Pino JC, Xia Y, Lopez CF, Meiler J
Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.
1. J. Virol. - published April 6, 2016
2. Kwon YD, Georgiev IS, Ofek G, Zhang B, Asokan M, Bailer RT, Bao A, Caruso W, Chen X, Choe M, Druz A, Ko SY, Louder MK, McKee K, O'Dell S, Pegu A, Rudicell RS, Shi W, Wang K, Yang Y, Alger M, Bender MF, Carlton K, Cooper JW, Blinn J, Eudailey J, Lloyd K, Parks R, Alam SM, Haynes BF, Padte NN, Yu J, Ho DD, Huang J, Connors M, Schwartz RM, Mascola JR, Kwong PD
The novel structure and unexpected RNA-binding ability of the C-terminal domain of HSV-1 tegument protein UL21.
1. J. Virol. - published April 6, 2016
2. Metrick CM, Heldwein EE
Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles.
1. Proc Natl Acad Sci U S A - published April 5, 2016
2. Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA
Structural Analysis of FRIGIDA Flowering-Time Regulator.
1. Mol Plant - published April 4, 2016
2. Hyun KG, Oh JE, Park J, Noh YS, Song JJ
Rate Control versus Rhythm Control for Atrial Fibrillation after Cardiac Surgery.
1. N. Engl. J. Med. - published April 4, 2016
2. Gillinov AM, Bagiella E, Moskowitz AJ, Raiten JM, Groh MA, Bowdish ME, Ailawadi G, Kirkwood KA, Perrault LP, Parides MK, Smith RL, Kern JA, Dussault G, Hackmann AE, Jeffries NO, Miller MA, Taddei-Peters WC, Rose EA, Weisel RD, Williams DL, Mangusan RF, Argenziano M, Moquete EG, O'Sullivan KL, Pellerin M, Shah KJ, Gammie JS, Mayer ML, Voisine P, Gelijns AC, O'Gara PT, Mack MJ, CTSN
Crystal structure of the human σ1 receptor.
1. Nature - published April 4, 2016
2. Schmidt HR, Zheng S, Gurpinar E, Koehl A, Manglik A, Kruse AC
Long antibody HCDR3s from HIV-naïve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization.
1. Proc. Natl. Acad. Sci. U.S.A. - published April 4, 2016
2. Willis JR, Finn JA, Briney B, Sapparapu G, Singh V, King H, LaBranche CC, Montefiori DC, Meiler J, Crowe JE
Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends.
1. Dev Cell - published April 4, 2016
2. Ti SC, Pamula MC, Howes SC, Duellberg C, Cade NI, Kleiner RE, Forth S, Surrey T, Nogales E, Kapoor TM
Molecular Dissection of Chromatin Maturation via Click Chemistry.
1. Curr Protoc Mol Biol - published April 3, 2016
2. Yildirim O, Kingston RE
In Situ Proteolysis for Crystallization of Membrane Bound Cytochrome P450 17A1 and 17A2 Proteins from Zebrafish.
1. Curr Protoc Protein Sci - published April 3, 2016
2. Lei L, Egli M
EM structure of a helicase-loader complex depicting a 6:2 binding sub-stoichiometry from Geobacillus kaustophilus HTA426.
1. Biochem Biophys Res Commun - published April 2, 2016
2. Lin YC, Naveen V, Hsiao CD
Mechanism of Paroxetine (Paxil) Inhibition of the Serotonin Transporter.
1. Sci Rep - published April 2, 2016
2. Davis BA, Nagarajan A, Forrest LR, Singh SK
A Taste Circuit that Regulates Ingestion by Integrating Food and Hunger Signals.
1. Cell - published April 2, 2016
2. Yapici N, Cohn R, Schusterreiter C, Ruta V, Vosshall LB
Lessons learned from a SIRT2-selective inhibitor.
1. Oncotarget - published April 2, 2016
2. Jing H, Lin H
Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides.
1. Proc Natl Acad Sci U S A - published April 2, 2016
2. Kapoor K, Finer-Moore JS, Pedersen BP, Caboni L, Waight A, Hillig RC, Bringmann P, Heisler I, Müller T, Siebeneicher H, Stroud RM
Microtubules: 50 years on from the discovery of tubulin.
1. Nat Rev Mol Cell Biol - published April 2, 2016
2. Borisy G, Heald R, Howard J, Janke C, Musacchio A, Nogales E
Protein-directed self-assembly of a fullerene crystal.
1. Nat Commun - published April 2, 2016
2. Kim KH, Ko DK, Kim YT, Kim NH, Paul J, Zhang SQ, Murray CB, Acharya R, DeGrado WF, Kim YH, Grigoryan G
Complete genomes of Hairstreak butterflies, their speciation, and nucleo-mitochondrial incongruence.
1. Sci Rep - published April 2, 2016
2. Cong Q, Shen J, Borek D, Robbins RK, Otwinowski Z, Grishin NV
The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition.
1. Elife - published April 2, 2016
2. Praissman JL, Willer T, Sheikh MO, Toi A, Chitayat D, Lin YY, Lee H, Stalnaker SH, Wang S, Prabhakar PK, Nelson SF, Stemple DL, Moore SA, Moremen KW, Campbell KP, Wells L
Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice.
1. Hepatology - published April 1, 2016
2. Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku CS, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J
Complementary Proteomic and Biochemical Analysis of Peptidases in Lobster Gastric Juice Uncovers the Functional Role of Individual Enzymes in Food Digestion.
1. Mar Biotechnol (NY) - published April 1, 2016
2. Bibo-Verdugo B, O'Donoghue AJ, Rojo-Arreola L, Craik CS, García-Carreño F
Human proximal tubule cells form functional microtissues.
1. Pflugers Arch - published April 1, 2016
2. Prange JA, Bieri M, Segerer S, Burger C, Kaech A, Moritz W, Devuyst O
Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response.
1. ChemMedChem - published April 1, 2016
2. Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR
Visualizing microtubule structural transitions and interactions with associated proteins.
1. Curr Opin Struct Biol - published April 1, 2016
2. Nogales E, Zhang R
Dynamics of the Tec-family tyrosine kinase SH3 domains.
1. Protein Sci - published April 1, 2016
2. Roberts JM, Tarafdar S, Joseph RE, Andreotti AH, Smithgall TE, Engen JR, Wales TE
Chimeric Filoviruses for Identification and Characterization of Monoclonal Antibodies.
1. J Virol - published April 1, 2016
2. Ilinykh PA, Shen X, Flyak AI, Kuzmina N, Ksiazek TG, Crowe JE Jr, Bukreyev A
Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease.
1. ChemMedChem - published April 1, 2016
2. Gable JE, Lee GM, Acker TM, Hulce KR, Gonzalez ER, Schweigler P, Melkko S, Farady CJ, Craik CS
A Two-Way Street: Regulatory Interplay between RNA Polymerase and Nascent RNA Structure.
1. Trends Biochem Sci - published April 1, 2016
2. Zhang J, Landick R
Arm-in-Arm Response Regulator Dimers Promote Intermolecular Signal Transduction.
1. J Bacteriol - published April 1, 2016
2. Baker AW, Satyshur KA, Moreno Morales N, Forest KT
Statistical modeling and removal of lipid membrane projections for cryo-EM structure determination of reconstituted membrane proteins.
1. J Struct Biol - published April 1, 2016
2. Jensen KH, Brandt SS, Shigematsu H, Sigworth FJ
Helicobacter pylori cell binding factor 2: Insights into domain motion.
1. J Struct Biol - published April 1, 2016
2. Naveen V, Chu CH, Chen BW, Tsai YC, Hsiao CD, Sun YJ
The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1.
1. J Biol Chem - published April 1, 2016
2. Boehm EM, Powers KT, Kondratick CM, Spies M, Houtman JC, Washington MT
Collagen VI deficiency reduces muscle pathology, but does not improve muscle function, in the γ-sarcoglycan-null mouse.
1. Hum Mol Genet - published April 1, 2016
2. de Greef JC, Hamlyn R, Jensen BS, O'Campo Landa R, Levy JR, Kobuke K, Campbell KP
Hypoxia as a therapy for mitochondrial disease.
1. Science - published April 1, 2016
2. Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK
A new view into prokaryotic cell biology from electron cryotomography.
1. Nat Rev Microbiol - published April 1, 2016
2. Oikonomou CM, Chang YW, Jensen GJ
Unique epigenetic influence of H2AX phosphorylation and H3K56 acetylation on normal stem cell radioresponses.
1. Mol Biol Cell - published April 1, 2016
2. Jacobs KM, Misri S, Meyer B, Raj S, Zobel CL, Sleckman BP, Hallahan DE, Sharma GG
Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.
1. Nat Struct Mol Biol - published April 1, 2016
2. Shukla S, Schmidt JC, Goldfarb KC, Cech TR, Parker R
In vivo risk evaluation of carbon-coated iron carbide nanoparticles based on short- and long-term exposure scenarios.
1. Nanomedicine (Lond) - published April 1, 2016
2. Herrmann IK, Beck-Schimmer B, Schumacher CM, Gschwind S, Kaech A, Ziegler U, Clavien PA, Günther D, Stark WJ, Graf R, Schlegel AA
Designed metalloprotein stabilizes a semiquinone radical.
1. Nat Chem - published April 1, 2016
2. Ulas G, Lemmin T, Wu Y, Gassner GT, DeGrado WF
Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands.
1. Sci Rep - published April 1, 2016
2. Vettoretti G, Moroni E, Sattin S, Tao J, Agard DA, Bernardi A, Colombo G
Functional architecture of the Reb1-Ter complex of Schizosaccharomyces pombe.
1. Proc Natl Acad Sci U S A - published April 1, 2016
2. Jaiswal R, Choudhury M, Zaman S, Singh S, Santosh V, Bastia D, Escalante CR
Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins.
1. Glycobiology - published April 1, 2016
2. Bensing BA, Khedri Z, Deng L, Yu H, Prakobphol A, Fisher SJ, Chen X, Iverson TM, Varki A, Sullam PM
I-bodies: human single domain antibodies that antagonize chemokine receptor CXCR4.
1. J. Biol. Chem. - published April 1, 2016
2. Griffiths K, Dolezal O, Cao B, Nilsson SK, See HB, Pfleger KD, Roche M, Gorry PR, Pow A, Viduka K, Lim K, Lu BG, Chang DH, Murray-Rust T, Kvansakul M, Perugini MA, Dogovski C, Doerflinger M, Zhang Y, Parisi K, Casey JL, Nuttall SD, Foley M
Taking a look at the calibration of a CCD detector with a fiber-optic taper.
1. J Appl Crystallogr - published April 1, 2016
2. Alkire RW, Rotella FJ, Duke NE, Otwinowski Z, Borek D
Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function.
1. Proc Natl Acad Sci U S A - published April 1, 2016
2. Sadhukhan S, Liu X, Ryu D, Nelson OD, Stupinski JA, Li Z, Chen W, Zhang S, Weiss RS, Locasale JW, Auwerx J, Lin H
Lysine fatty acylation promotes lysosomal targeting of TNF-α.
1. Sci Rep - published April 1, 2016
2. Jiang H, Zhang X, Lin H
Innovative Solutions to Sticky Situations: Antiadhesive Strategies for Treating Bacterial Infections.
1. Microbiol Spectr - published April 1, 2016
2. Cusumano ZT, Klein RD, Hultgren SJ
<i>DCC</i>: a Swiss army knife for structure factor analysis and validation.
1. J Appl Crystallogr - published April 1, 2016
2. Yang H, Peisach E, Westbrook JD, Young J, Berman HM, Burley SK