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141 Member Publications for March 2016

Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition.
1. Sci Signal - published March 31, 2016
2. Kahle KT, Schmouth JF, Lavastre V, Latremoliere A, Zhang J, Andrews N, Omura T, Laganière J, Rochefort D, Hince P, Castonguay G, Gaudet R, Mapplebeck JC, Sotocinal SG, Duan J, Ward C, Khanna AR, Mogil JS, Dion PA, Woolf CJ, Inquimbert P, Rouleau GA
Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome.
1. Nature - published March 31, 2016
2. Cavadini S, Fischer ES, Bunker RD, Potenza A, Lingaraju GM, Goldie KN, Mohamed WI, Faty M, Petzold G, Beckwith RE, Tichkule RB, Hassiepen U, Abdulrahman W, Pantelic RS, Matsumoto S, Sugasawa K, Stahlberg H, Thomä NH
Impaired mechanical response of an EDMD mutation leads to motility phenotypes that are repaired by loss of prenylation.
1. J. Cell. Sci. - published March 31, 2016
2. Zuela N, Zwerger M, Levin T, Medalia O, Gruenbaum Y
The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.
1. J. Med. Chem. - published March 30, 2016
2. Unzue A, Zhao H, Lolli G, Dong J, Zhu J, Zechner M, Dolbois A, Caflisch A, Nevado C
Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model.
1. Nat. Rev. Microbiol. - published March 30, 2016
2. Okuda S, Sherman DJ, Silhavy TJ, Ruiz N, Kahne D
Structural basis of cohesin cleavage by separase.
1. Nature - published March 30, 2016
2. Lin Z, Luo X, Yu H
Sleeping Beauty transposase structure allows rational design of hyperactive variants for genetic engineering.
1. Nat Commun - published March 30, 2016
2. Voigt F, Wiedemann L, Zuliani C, Querques I, Sebe A, Mátés L, Izsvák Z, Ivics Z, Barabas O
Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition.
1. Proc. Natl. Acad. Sci. U.S.A. - published March 29, 2016
2. Chaudhuri D, Artiga DJ, Abiria SA, Clapham DE
The melting pot of the MHC II peptidome.
1. Curr. Opin. Immunol. - published March 29, 2016
2. Stern LJ, Santambrogio L
Integrative NMR for biomolecular research.
1. J. Biomol. NMR - published March 29, 2016
2. Lee W, Cornilescu G, Dashti H, Eghbalnia HR, Tonelli M, Westler WM, Butcher SE, Henzler-Wildman KA, Markley JL
Molecular basis for multimerization in the activation of the epidermal growth factor receptor.
1. Elife - published March 28, 2016
2. Huang Y, Bharill S, Karandur D, Peterson SM, Marita M, Shi X, Kaliszewski MJ, Smith AW, Isacoff EY, Kuriyan J
PilN binding modulates the structure and binding partners of the Pseudomonas aeruginosa Type IVa Pilus protein PilM.
1. J. Biol. Chem. - published March 28, 2016
2. McCallum M, Tammam S, Little DJ, Robinson H, Koo J, Shah M, Calmettes C, Moraes TF, Burrows LL, Howell PL
A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
1. J. Mol. Biol. - published March 27, 2016
2. Duffy CM, Hilbert BJ, Kelch BA
Generation of Fluorogen-Activating Designed Ankyrin Repeat Proteins (FADAs) as Versatile Sensor Tools.
1. J. Mol. Biol. - published March 27, 2016
2. Schütz M, Batyuk A, Klenk C, Kummer L, de Picciotto S, Gülbakan B, Wu Y, Newby GA, Zosel F, Schöppe J, Sedlák E, Mittl PR, Zenobi R, Wittrup KD, Plückthun A
Delivery of Therapeutic Proteins via Extracellular Vesicles: Review and Potential Treatments for Parkinson's Disease, Glioma, and Schwannoma.
1. Cell. Mol. Neurobiol. - published March 26, 2016
2. Hall J, Prabhakar S, Balaj L, Lai CP, Cerione RA, Breakefield XO
Modulation of Intrinsically Disordered Protein Function by Post-translational Modifications.
1. J. Biol. Chem. - published March 25, 2016
2. Bah A, Forman-Kay JD
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.
1. Nat Commun - published March 25, 2016
2. Almqvist H, Axelsson H, Jafari R, Dan C, Mateus A, Haraldsson M, Larsson A, Martinez Molina D, Artursson P, Lundbäck T, Nordlund P
Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.
1. Nat Commun - published March 25, 2016
2. Janowski R, Heinz GA, Schlundt A, Wommelsdorf N, Brenner S, Gruber AR, Blank M, Buch T, Buhmann R, Zavolan M, Niessing D, Heissmeyer V, Sattler M
Correlative light and electron microscopy methods for the study of virus-cell interactions.
1. FEBS Lett. - published March 25, 2016
2. Bykov YS, Cortese M, Briggs JA, Bartenschlager R
Retrovirus maturation-an extraordinary structural transformation.
1. Curr Opin Virol - published March 25, 2016
2. Mattei S, Schur FK, Briggs JA
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.
1. Science - published March 25, 2016
2. Jardine JG, Kulp DW, Havenar-Daughton C, Sarkar A, Briney B, Sok D, Sesterhenn F, Ereño-Orbea J, Kalyuzhniy O, Deresa I, Hu X, Spencer S, Jones M, Georgeson E, Adachi Y, Kubitz M, deCamp AC, Julien JP, Wilson IA, Burton DR, Crotty S, Schief WR
N-Terminal Amino Acid Sequence Determination of Proteins by N-Terminal Dimethyl Labeling: Pitfalls and Advantages When Compared with Edman Degradation Sequence Analysis.
1. J Biomol Tech - published March 24, 2016
2. Chang E, Pourmal S, Zhou C, Kumar R, Teplova M, Pavletich NP, Marians KJ, Erdjument-Bromage H
The Fragment 1 Region of Prothrombin Facilitates the Favored Binding of Fragment 12 to Zymogen and Enforces Zymogen-like Character in the Proteinase.
1. J. Biol. Chem. - published March 24, 2016
2. Bradford HN, Krishnaswamy S
NMRmix: A Tool for the Optimization of Compound Mixtures in 1D (1)H NMR Ligand Affinity Screens.
1. J. Proteome Res. - published March 23, 2016
2. Stark JL, Eghbalnia HR, Lee W, Westler WM, Markley JL
Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies.
1. Nat Chem - published March 23, 2016
2. Shivatare SS, Chang SH, Tsai TI, Tseng SY, Shivatare VS, Lin YS, Cheng YY, Ren CT, Lee CC, Pawar S, Tsai CS, Shih HW, Zeng YF, Liang CH, Kwong PD, Burton DR, Wu CY, Wong CH
Primary cilia are not calcium-responsive mechanosensors.
1. Nature - published March 23, 2016
2. Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DE
Structural basis for germline antibody recognition of HIV-1 immunogens.
1. Elife - published March 22, 2016
2. Scharf L, West AP, Sievers SA, Chen C, Jiang S, Gao H, Gray MD, McGuire AT, Scheid JF, Nussenzweig MC, Stamatatos L, Bjorkman PJ
Delivery of RANKL-Binding Peptide OP3-4 Promotes BMP-2-Induced Maxillary Bone Regeneration.
1. J. Dent. Res. - published March 22, 2016
2. Uehara T, Mise-Omata S, Matsui M, Tabata Y, Murali R, Miyashin M, Aoki K
Molecular Mechanism of Processive 3' to 5' RNA Translocation in the Active Subunit of the RNA Exosome Complex.
1. J. Am. Chem. Soc. - published March 21, 2016
2. Vuković L, Chipot C, Makino DL, Conti E, Schulten K
Suppression of WHITE COLLAR-independent frequency Transcription by Histone H3 Lysine 36 Methyltransferase SET-2 Is Necessary for Clock Function in Neurospora.
1. J. Biol. Chem. - published March 21, 2016
2. Sun G, Zhou Z, Liu X, Gai K, Liu Q, Cha J, Kaleri FN, Wang Y, He Q
The Inhibitory Site of a Diguanylate Cyclase is a Necessary Element for Interaction and Signaling with an Effector Protein.
1. J. Bacteriol. - published March 21, 2016
2. Dahlstrom KM, Giglio KM, Sondermann H, O'Toole GA
Suramin inhibits cullin-RING E3 ubiquitin ligases.
1. Proc. Natl. Acad. Sci. U.S.A. - published March 21, 2016
2. Wu K, Chong RA, Yu Q, Bai J, Spratt DE, Ching K, Lee C, Miao H, Tappin I, Hurwitz J, Zheng N, Shaw GS, Sun Y, Felsenfeld DP, Sanchez R, Zheng JN, Pan ZQ
Multilevel summation with B-spline interpolation for pairwise interactions in molecular dynamics simulations.
1. J Chem Phys - published March 21, 2016
2. Hardy DJ, Wolff MA, Xia J, Schulten K, Skeel RD
High-Throughput Fragment Docking into the BAZ2B Bromodomain: Efficient in Silico Screening for X-Ray Crystallography.
1. ACS Chem. Biol. - published March 18, 2016
2. Lolli G, Caflisch A
Exploring the Mechanism Responsible for Cellulase Thermostability by Structure-Guided Recombination.
1. PLoS One - published March 18, 2016
2. Chang CJ, Lee CC, Chan YT, Trudeau DL, Wu MH, Tsai CH, Yu SM, Ho TH, Wang AH, Hsiao CD, Arnold FH, Chao YC
Fine-tuning of a radical-based reaction by radical S-adenosyl-L-methionine tryptophan lyase.
1. Science - published March 18, 2016
2. Sicoli G, Mouesca JM, Zeppieri L, Amara P, Martin L, Barra AL, Fontecilla-Camps JC, Gambarelli S, Nicolet Y
BIOCHEMISTRY. A radically unexpected mechanism.
1. Science - published March 18, 2016
2. Bridwell-Rabb J, Drennan CL
Elucidation of the Dynamics of Transcription Elongation by RNA Polymerase II using Kinetic Network Models.
1. Acc. Chem. Res. - published March 18, 2016
2. Zhang L, Pardo-Avila F, Unarta IC, Cheung PP, Wang G, Wang D, Huang X
Observing cellulose biosynthesis and membrane translocation in crystallo.
1. Nature - published March 17, 2016
2. Morgan JL, McNamara JT, Fischer M, Rich J, Chen HM, Withers SG, Zimmer J
MamO Is a Repurposed Serine Protease that Promotes Magnetite Biomineralization through Direct Transition Metal Binding in Magnetotactic Bacteria.
1. PLoS Biol. - published March 17, 2016
2. Hershey DM, Ren X, Melnyk RA, Browne PJ, Ozyamak E, Jones SR, Chang MC, Hurley JH, Komeili A
Molecular and Structural Characterization of a Novel Escherichia coli Interleukin Receptor Mimic Protein.
1. MBio - published March 17, 2016
2. Moriel DG, Heras B, Paxman JJ, Lo AW, Tan L, Sullivan MJ, Dando SJ, Beatson SA, Ulett GC, Schembri MA
Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.
1. Mol. Cell - published March 17, 2016
2. Anders C, Bargsten K, Jinek M
Structure and Energetic Contributions of a Designed Modular Peptide-Binding Protein with Picomolar Affinity.
1. J. Am. Chem. Soc. - published March 16, 2016
2. Hansen S, Tremmel D, Madhurantakam C, Reichen C, Mittl PR, Plückthun A
Time-Resolved Visualisation of Nearly-Native Influenza A Virus Progeny Ribonucleoproteins and Their Individual Components in Live Infected Cells.
1. PLoS ONE - published March 16, 2016
2. Avilov S, Magnus J, Cusack S, Naffakh N
The human Ska complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores.
1. Elife - published March 16, 2016
2. Sivakumar S, Janczyk PŁ, Qu Q, Brautigam CA, Stukenberg PT, Yu H, Gorbsky GJ
Leukocyte integrin αLβ2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops.
1. Proc. Natl. Acad. Sci. U.S.A. - published March 15, 2016
2. Sen M, Springer TA
Complex Antigens Drive Permissive Clonal Selection in Germinal Centers.
1. Immunity - published March 15, 2016
2. Kuraoka M, Schmidt AG, Nojima T, Feng F, Watanabe A, Kitamura D, Harrison SC, Kepler TB, Kelsoe G
Nitrogenase FeMoco investigated by spatially resolved anomalous dispersion refinement.
1. Nat Commun - published March 15, 2016
2. Spatzal T, Schlesier J, Burger EM, Sippel D, Zhang L, Andrade SL, Rees DC, Einsle O
Autoimmune response to transthyretin in juvenile idiopathic arthritis.
1. JCI Insight - published March 15, 2016
2. Clement CC, Moncriefe H, Lele A, Janow G, Becerra A, Bauli F, Saad FA, Perino G, Montagna C, Cobelli N, Hardin J, Stern LJ, Ilowite N, Porcelli SA, Santambrogio L
Metalloprotein Crystallography: More than a Structure.
1. Acc. Chem. Res. - published March 15, 2016
2. Bowman SE, Bridwell-Rabb J, Drennan CL
Early attentional bias for negative words when competition is induced.
1. Atten Percept Psychophys - published March 15, 2016
2. Ho MC, Li SH, Yeh SL
Adhesive Pili in UTI Pathogenesis and Drug Development.
1. Pathogens - published March 15, 2016
2. Spaulding CN, Hultgren SJ
Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions.
1. Elife - published March 14, 2016
2. Dong X, Chiu H, Park YJ, Zou W, Zou Y, Özkan E, Chang C, Shen K
Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function.
1. Proc. Natl. Acad. Sci. U.S.A. - published March 14, 2016
2. Scherer PC, Ding Y, Liu Z, Xu J, Mao H, Barrow JC, Wei N, Zheng N, Snyder SH, Rao F
SARS-like WIV1-CoV poised for human emergence.
1. Proc. Natl. Acad. Sci. U.S.A. - published March 14, 2016
2. Menachery VD, Yount BL, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR, Swanstrom J, Sheahan TP, Pickles RJ, Corti D, Randell SH, Lanzavecchia A, Marasco WA, Baric RS
Photolabeling a Nicotinic Acetylcholine Receptor (nAChR) with an (α4)3(β2)2 nAChR-selective Positive Allosteric Modulator.
1. Mol. Pharmacol. - published March 14, 2016
2. Hamouda AK, Deba F, Wang ZJ, Cohen JB
Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.
1. Proc. Natl. Acad. Sci. U.S.A. - published March 14, 2016
2. Gorelik M, Orlicky S, Sartori MA, Tang X, Marcon E, Kurinov I, Greenblatt JF, Tyers M, Moffat J, Sicheri F, Sidhu SS
Spatiotemporal variation of mammalian protein complex stoichiometries.
1. Genome Biol. - published March 14, 2016
2. Ori A, Iskar M, Buczak K, Kastritis P, Parca L, Andrés-Pons A, Singer S, Bork P, Beck M
Frizzled Receptors in Development and Disease.
1. Curr Top Dev Biol - published March 13, 2016
2. Wang Y, Chang H, Rattner A, Nathans J
Small GTPases and their GAPs.
1. Biopolymers - published March 12, 2016
2. Mishra AK, Lambright DG
The Dendritic Cell Major Histocompatibility Complex II (MHC II) Peptidome Derives from a Variety of Processing Pathways and Includes Peptides with a Broad Spectrum of HLA-DM Sensitivity.
1. J. Biol. Chem. - published March 11, 2016
2. Clement CC, Becerra A, Yin L, Zolla V, Huang L, Merlin S, Follenzi A, Shaffer SA, Stern LJ, Santambrogio L
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.
1. Science - published March 11, 2016
2. Kryukov GV, Wilson FH, Ruth JR, Paulk J, Tsherniak A, Marlow SE, Vazquez F, Weir BA, Fitzgerald ME, Tanaka M, Bielski CM, Scott JM, Dennis C, Cowley GS, Boehm JS, Root DE, Golub TR, Clish CB, Bradner JE, Hahn WC, Garraway LA
From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis.
1. J. Am. Chem. Soc. - published March 11, 2016
2. Eser BE, Zhang X, Chanani PK, Begley TP, Ealick SE
Intracellular nanoparticles mass quantification by near-edge absorption soft X-ray nanotomography.
1. Sci Rep - published March 11, 2016
2. Conesa JJ, Otón J, Chiappi M, Carazo JM, Pereiro E, Chichón FJ, Carrascosa JL
Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies.
1. J. Am. Chem. Soc. - published March 11, 2016
2. Ehsan M, Du Y, Scull NJ, Tikhonova E, Tarrasch J, Mortensen JS, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS
Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin (CaM) Variants in Long QT Syndrome (LQTS) and Functional Characterization of a Novel LQTS-Associated CaM Missense Variant, E141G.
1. Circ Cardiovasc Genet - published March 11, 2016
2. Boczek NJ, Gomez-Hurtado N, Ye D, Calvert ML, Tester DJ, Kryshtal D, Hwang HS, Johnson CN, Chazin WJ, Loporcaro CG, Shah M, Papez AL, Lau YR, Kanter R, Knollmann BC, Ackerman MJ
Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole Synthases.
1. Biochemistry - published March 10, 2016
2. Zhang X, Eser BE, Chanani PK, Begley TP, Ealick SE
Structural dataset for the fast-exchanging KRAS G13D.
1. Data Brief - published March 10, 2016
2. Lu J, Hunter J, Manandhar A, Gurbani D, Westover KD
Efficient merging of data from multiple samples for determination of anomalous substructure.
1. Acta Crystallogr D Struct Biol - published March 10, 2016
2. Akey DL, Terwilliger TC, Smith JL
Data-collection strategy for challenging native SAD phasing.
1. Acta Crystallogr D Struct Biol - published March 10, 2016
2. Olieric V, Weinert T, Finke AD, Anders C, Li D, Olieric N, Borca CN, Steinmetz MO, Caffrey M, Jinek M, Wang M
Humanized mouse G6 anti-idiotypic monoclonal antibody has therapeutic potential against IGHV1-69 germline gene-based B-CLL.
1. MAbs - published March 10, 2016
2. Chang DK, Kurella VB, Biswas S, Avnir Y, Sui J, Wang X, Sun J, Wang Y, Panditrao M, Peterson E, Tallarico A, Fernandes S, Goodall M, Zhu Q, Brown JR, Jefferis R, Marasco WA
The Nuclear Pore Complex as a Flexible and Dynamic Gate.
1. Cell - published March 10, 2016
2. Knockenhauer KE, Schwartz TU
The Dark Side of Cell Signaling: Positive Roles for Negative Regulators.
1. Cell - published March 10, 2016
2. Lemmon MA, Freed DM, Schlessinger J, Kiyatkin A
Potassium and the K+/H+ Exchanger Kha1p Promote Binding of Copper to Apo-Fet3p Multi-Copper Ferroxidase.
1. J. Biol. Chem. - published March 10, 2016
2. Wu X, Kim H, Seravalli J, Barycki JJ, Hart PJ, Gohara DW, Di Cera E, Jung WH, Kosman DJ, Lee J
Exploring the Structure of Glutamate Racemase from Mycobacterium tuberculosis as a Template for Anti-mycobacterial Drug Discovery.
1. Biochem. J. - published March 10, 2016
2. Poen S, Nakatani Y, Opel-Reading HK, Lassé M, Dobson RC, Krause KL
Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition.
1. ACS Med Chem Lett - published March 10, 2016
2. Melillo B, Liang S, Park J, Schön A, Courter JR, LaLonde JM, Wendler DJ, Princiotto AM, Seaman MS, Freire E, Sodroski J, Madani N, Hendrickson WA, Smith AB
HIV-Host Interactions: Implications for Vaccine Design.
1. Cell Host Microbe - published March 9, 2016
2. Haynes BF, Shaw GM, Korber B, Kelsoe G, Sodroski J, Hahn BH, Borrow P, McMichael AJ
Progress on Covalent Inhibition of KRAS(G12C).
1. Cancer Discov - published March 9, 2016
2. Westover KD, Jänne PA, Gray NS
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
1. Nature - published March 9, 2016
2. Thal DM, Sun B, Feng D, Nawaratne V, Leach K, Felder CC, Bures MG, Evans DA, Weis WI, Bachhawat P, Kobilka TS, Sexton PM, Kobilka BK, Christopoulos A
Lens regeneration using endogenous stem cells with gain of visual function.
1. Nature - published March 9, 2016
2. Lin H, Ouyang H, Zhu J, Huang S, Liu Z, Chen S, Cao G, Li G, Signer RA, Xu Y, Chung C, Zhang Y, Lin D, Patel S, Wu F, Cai H, Hou J, Wen C, Jafari M, Liu X, Luo L, Zhu J, Qiu A, Hou R, Chen B, Chen J, Granet D, Heichel C, Shang F, Li X, Krawczyk M, Skowronska-Krawczyk D, Wang Y, Shi W, Chen D, Zhong Z, Zhong S, Zhang L, Chen S, Morrison SJ, Maas RL, Zhang K, Liu Y
Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module.
1. Angew. Chem. Int. Ed. Engl. - published March 9, 2016
2. Jbara M, Maity SK, Morgan M, Wolberger C, Brik A
Origin and prediction of free-solution interaction studies performed label-free.
1. Proc. Natl. Acad. Sci. U.S.A. - published March 9, 2016
2. Bornhop DJ, Kammer MN, Kussrow A, Flowers RA, Meiler J
Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds.
1. J. Virol. - published March 9, 2016
2. Madani N, Princiotto AM, Easterhoff D, Bradley T, Luo K, Williams WB, Liao HX, Moody MA, Phad GE, Vázquez Bernat N, Melillo B, Santra S, Smith AB, Karlsson Hedestam GB, Haynes B, Sodroski J
Substrate and pH-Dependent Kinetic Profile of 3-Mercaptopropionate Dioxygenase from Pseudomonas aeruginosa.
1. Biochemistry - published March 8, 2016
2. Fellner M, Aloi S, Tchesnokov EP, Wilbanks SM, Jameson GN
Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function.
1. Cell Rep - published March 8, 2016
2. Muir KW, Kschonsak M, Li Y, Metz J, Haering CH, Panne D
Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein.
1. Cell Rep - published March 8, 2016
2. Ben Halima S, Mishra S, Raja KM, Willem M, Baici A, Simons K, Brüstle O, Koch P, Haass C, Caflisch A, Rajendran L
Data publication with the structural biology data grid supports live analysis.
1. Nat Commun - published March 8, 2016
2. Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Christopher Fromme J, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P
Editorial overview: Nucleic acids and their protein complexes.
1. Curr. Opin. Struct. Biol. - published March 8, 2016
2. Lilley DM, Pyle AM
A saposin-lipoprotein nanoparticle system for membrane proteins.
1. Nat. Methods - published March 8, 2016
2. Frauenfeld J, Löving R, Armache JP, Sonnen AF, Guettou F, Moberg P, Zhu L, Jegerschöld C, Flayhan A, Briggs JA, Garoff H, Löw C, Cheng Y, Nordlund P
Epigenomic landscapes of retinal rods and cones.
1. Elife - published March 7, 2016
2. Mo A, Luo C, Davis FP, Mukamel EA, Henry GL, Nery JR, Urich MA, Picard S, Lister R, Eddy SR, Beer MA, Ecker JR, Nathans J
Crystal structure of a substrate-engaged SecY protein-translocation channel.
1. Nature - published March 7, 2016
2. Li L, Park E, Ling J, Ingram J, Ploegh H, Rapoport TA
Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
1. Nat. Struct. Mol. Biol. - published March 7, 2016
2. Yin J, Babaoglu K, Brautigam CA, Clark L, Shao Z, Scheuermann TH, Harrell CM, Gotter AL, Roecker AJ, Winrow CJ, Renger JJ, Coleman PJ, Rosenbaum DM
Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II.
1. Elife - published March 7, 2016
2. Bhattacharyya M, Stratton MM, Going CC, McSpadden ED, Huang Y, Susa AC, Elleman A, Cao YM, Pappireddi N, Burkhardt P, Gee CL, Barros T, Schulman H, Williams ER, Kuriyan J
Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride.
1. Protein Cell - published March 7, 2016
2. Zhao L, Wang S, Du L, Dev J, Zhou L, Liu Z, Chou JJ, OuYang B
Structure and mechanism of the phage T4 recombination mediator protein UvsY.
1. Proc. Natl. Acad. Sci. U.S.A. - published March 7, 2016
2. Gajewski S, Waddell MB, Vaithiyalingam S, Nourse A, Li Z, Woetzel N, Alexander N, Meiler J, White SW
Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels.
1. PLoS Biol. - published March 5, 2016
2. Bertozzi C, Zimmermann I, Engeler S, Hilf RJ, Dutzler R
Three Recombinant Engineered Antibodies against Recombinant Tags with High Affinity and Specificity.
1. PLoS ONE - published March 5, 2016
2. Zhao H, Shen A, Xiang YK, Corey DP
The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins.
1. Elife - published March 5, 2016
2. Stadtmueller BM, Huey-Tubman KE, López CJ, Yang Z, Hubbell WL, Bjorkman PJ
MyoD promotes porcine PPARγ gene expression through an E-box and a MyoD-binding site in the PPARγ promoter region.
1. Cell Tissue Res. - published March 5, 2016
2. Deng B, Zhang F, Chen K, Wen J, Huang H, Liu W, Ye S, Wang L, Yang Y, Gong P, Jiang S
Human acetyl-CoA:glucosamine-6-phosphate N-acetyltransferase 1 has a relaxed donor specificity and transfers acyl groups up to four carbons in length.
1. Biochem. Cell Biol. - published March 4, 2016
2. Brockhausen I, Nair DG, Chen M, Yang X, Allingham JS, Szarek WA, Anastassiades T
Plasma d-Dimer as a Useful Marker Predicts Severity of Atherosclerotic Lesion and Short-Term Outcome in Patients With Coronary Artery Disease.
1. Clin. Appl. Thromb. Hemost. - published March 4, 2016
2. Gong P, Yang SH, Li S, Luo SH, Zeng RX, Zhang Y, Guo YL, Zhu CG, Xu RX, Li JJ
Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
1. J. Org. Chem. - published March 4, 2016
2. Kel'in AV, Zlatev I, Harp J, Jayaraman M, Bisbe A, O'Shea J, Taneja N, Manoharan RM, Khan S, Charisse K, Maier MA, Egli M, Rajeev KG, Manoharan M
EspP, an Extracellular Serine Protease from Enterohemorrhagic E. coli, Reduces Coagulation Factor Activities, Reduces Clot Strength, and Promotes Clot Lysis.
1. PLoS ONE - published March 3, 2016
2. Kuo KH, Khan S, Rand ML, Mian HS, Brnjac E, Sandercock LE, Akula I, Julien JP, Pai EF, Chesney AE
Autism Linked to Increased Oncogene Mutations but Decreased Cancer Rate.
1. PLoS ONE - published March 3, 2016
2. Darbro BW, Singh R, Zimmerman MB, Mahajan VB, Bassuk AG
Pre-fusion structure of a human coronavirus spike protein.
1. Nature - published March 3, 2016
2. Kirchdoerfer RN, Cottrell CA, Wang N, Pallesen J, Yassine HM, Turner HL, Corbett KS, Graham BS, McLellan JS, Ward AB
Response to Sandford et al.: PRICKLE2 Variants in Epilepsy: A Call for Precision Medicine.
1. Am. J. Hum. Genet. - published March 3, 2016
2. Mahajan VB, Bassuk AG
Speciation in Cloudless Sulphurs Gleaned from Complete Genomes.
1. Genome Biol Evol - published March 3, 2016
2. Cong Q, Shen J, Warren AD, Borek D, Otwinowski Z, Grishin NV
Structure of promoter-bound TFIID and model of human pre-initiation complex assembly.
1. Nature - published March 3, 2016
2. Louder RK, He Y, López-Blanco JR, Fang J, Chacón P, Nogales E
Structural insight in the toppling mechanism of an energy-coupling factor transporter.
1. Nat Commun - published March 3, 2016
2. Swier LJ, Guskov A, Slotboom DJ
How scientists can reduce their carbon footprint.
1. Elife - published March 3, 2016
2. Nathans J, Sterling P
Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.
1. Sci Rep - published March 2, 2016
2. Jung B, Messias AC, Schorpp K, Geerlof A, Schneider G, Saur D, Hadian K, Sattler M, Wanker EE, Hasenöder S, Lickert H
Diverse high-torque bacterial flagellar motors assemble wider stator rings using a conserved protein scaffold.
1. Proc Natl Acad Sci U S A - published March 2, 2016
2. Beeby M, Ribardo DA, Brennan CA, Ruby EG, Jensen GJ, Hendrixson DR
Huntingtin's spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function.
1. Elife - published March 2, 2016
2. Vijayvargia R, Epand R, Leitner A, Jung TY, Shin B, Jung R, Lloret A, Singh Atwal R, Lee H, Lee JM, Aebersold R, Hebert H, Song JJ, Seong IS
Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles.
1. Biochimie - published March 1, 2016
2. Dvořák J, Fajtová P, Ulrychová L, Leontovyč A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey CR, O'Donoghue AJ
V1/V2 Neutralizing Epitope is Conserved in Divergent Non-M Groups of HIV-1.
1. J. Acquir. Immune Defic. Syndr. - published March 1, 2016
2. Morgand M, Bouvin-Pley M, Plantier JC, Moreau A, Alessandri E, Simon F, Pace CS, Pancera M, Ho DD, Poignard P, Bjorkman PJ, Mouquet H, Nussenzweig MC, Kwong PD, Baty D, Chames P, Braibant M, Barin F
In vivo imaging of protease activity by Probody therapeutic activation.
1. Biochimie - published March 1, 2016
2. Wong KR, Menendez E, Craik CS, Kavanaugh WM, Vasiljeva O
Zinc supplementation induces regulatory T cells by inhibition of Sirt-1 deacetylase in mixed lymphocyte cultures.
1. Mol Nutr Food Res - published March 1, 2016
2. Rosenkranz E, Metz CH, Maywald M, Hilgers RD, Weßels I, Senff T, Haase H, Jäger M, Ott M, Aspinall R, Plümäkers B, Rink L
Effect of SLC26 anion transporter disease-causing mutations on the stability of the homologous STAS domain of E. coli DauA (YchM).
1. Biochem J - published March 1, 2016
2. Bai X, Moraes TF, Reithmeier RA
Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana.
1. Nature - published March 1, 2016
2. Guo J, Zeng W, Chen Q, Lee C, Chen L, Yang Y, Cang C, Ren D, Jiang Y
The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.
1. J Struct Biol - published March 1, 2016
2. Gay DC, Wagner DT, Meinke JL, Zogzas CE, Gay GR, Keatinge-Clay AT
Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations.
1. Proteins - published March 1, 2016
2. Capoferri L, Leth R, ter Haar E, Mohanty AK, Grootenhuis PD, Vottero E, Commandeur JN, Vermeulen NP, Jørgensen FS, Olsen L, Geerke DP
Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition.
1. J Biol Chem - published March 1, 2016
2. Wangkanont K, Wesener DA, Vidani JA, Kiessling LL, Forest KT
Optimizing selection of large animals for antibody production by screening immune response to standard vaccines.
1. J Immunol Methods - published March 1, 2016
2. Thompson MK, Fridy PC, Keegan S, Chait BT, Fenyö D, Rout MP
Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses.
1. ACS Chem Biol - published March 1, 2016
2. Conrad RJ, Ott M
A Robust Workflow for Native Mass Spectrometric Analysis of Affinity-Isolated Endogenous Protein Assemblies.
1. Anal Chem - published March 1, 2016
2. Olinares PD, Dunn AD, Padovan JC, Fernandez-Martinez J, Rout MP, Chait BT
Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.
1. Structure - published March 1, 2016
2. Croll TI, Smith BJ, Margetts MB, Whittaker J, Weiss MA, Ward CW, Lawrence MC
Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues.
1. Biochemistry - published March 1, 2016
2. Xie X, Garg A, Keatinge-Clay AT, Khosla C, Cane DE
A common 'aggregation-prone' interface possibly participates in the self-assembly of human zona pellucida proteins.
1. FEBS Lett - published March 1, 2016
2. Louros NN, Chrysina ED, Baltatzis GE, Patsouris ES, Hamodrakas SJ, Iconomidou VA
SIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context.
1. ACS Chem Biol - published March 1, 2016
2. Tong Z, Wang Y, Zhang X, Kim DD, Sadhukhan S, Hao Q, Lin H
Purification, crystallization and initial crystallographic analysis of the α-catenin homologue HMP-1 from Caenorhabditis elegans.
1. Acta Crystallogr F Struct Biol Commun - published March 1, 2016
2. Kang H, Bang I, Weis WI, Choi HJ
Classic Spotlight: Crowd Sourcing Provided Penicillium Strains for the War Effort.
1. J Bacteriol - published March 1, 2016
2. Forest KT, Stock AM
Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α.
1. Elife - published March 1, 2016
2. Placzek AN, Molfese DL, Khatiwada S, Viana Di Prisco G, Huang W, Sidrauski C, Krnjević K, Amos CL, Ray R, Dani JA, Walter P, Salas R, Costa-Mattioli M
Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine.
1. Elife - published March 1, 2016
2. Huang W, Placzek AN, Viana Di Prisco G, Khatiwada S, Sidrauski C, Krnjević K, Walter P, Dani JA, Costa-Mattioli M
Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.
1. Angew Chem Int Ed Engl - published March 1, 2016
2. Speltz TE, Fanning SW, Mayne CG, Fowler C, Tajkhorshid E, Greene GL, Moore TW
A Functional NMR for Membrane Proteins: Dynamics, Ligand Binding, and Allosteric Modulation.
1. Protein Sci. - published March 1, 2016
2. Oxenoid K, Chou JJ
A Structural Perspective on Readout of Epigenetic Histone and DNA Methylation Marks.
1. Cold Spring Harb Perspect Biol - published March 1, 2016
2. Patel DJ
Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana.
1. Nature - published March 1, 2016
2. Kintzer AF, Stroud RM
Architecture of the type IVa pilus machine.
1. Science - published March 1, 2016
2. Chang YW, Rettberg LA, Treuner-Lange A, Iwasa J, Søgaard-Andersen L, Jensen GJ
A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity.
1. Cancer Cell - published March 1, 2016
2. Jing H, Hu J, He B, Negrón Abril YL, Stupinski J, Weiser K, Carbonaro M, Chiang YL, Southard T, Giannakakou P, Weiss RS, Lin H
Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.
1. PLoS Comput Biol - published March 1, 2016
2. Chopra N, Wales TE, Joseph RE, Boyken SE, Engen JR, Jernigan RL, Andreotti AH
Fragment-based in silico screening of bromodomain ligands.
1. Drug Discov Today Technol - published March 1, 2016
2. Spiliotopoulos D, Caflisch A