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150 Member Publications for February 2016

Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
1. Biochemistry - published February 29, 2016
2. Mills SJ, Silvander C, Cozier G, Trésaugues L, Nordlund P, Potter BV
Bringing Bioactive Compounds into Membranes: The UbiA Superfamily of Intramembrane Aromatic Prenyltransferases.
1. Trends Biochem. Sci. - published February 29, 2016
2. Li W
Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling.
1. Chem. Rev. - published February 29, 2016
2. Csizmok V, Follis AV, Kriwacki RW, Forman-Kay JD
Structural plasticity and in vivo activity of Cas1 from the type I-F CRISPR-Cas system.
1. Biochem. J. - published February 29, 2016
2. Wilkinson ME, Nakatani Y, Staals RH, Kieper SN, Opel-Reading HK, McKenzie RE, Fineran PC, Krause KL
Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications.
1. Breast Cancer Res. - published February 28, 2016
2. Bashari MH, Fan F, Vallet S, Sattler M, Arn M, Luckner-Minden C, Schulze-Bergkamen H, Zörnig I, Marme F, Schneeweiss A, Cardone MH, Opferman JT, Jäger D, Podar K
Structure and function of the ULK1 complex in autophagy.
1. Curr. Opin. Cell Biol. - published February 28, 2016
2. Lin MG, Hurley JH
Structural Analysis of Multi-Helical RNAs by NMR-SAXS/WAXS: Application to the U4/U6 di-snRNA.
1. J. Mol. Biol. - published February 27, 2016
2. Cornilescu G, Didychuk AL, Rodgers ML, Michael LA, Burke JE, Montemayor EJ, Hoskins AA, Butcher SE
Challenges in RNA Structural Modeling and Design.
1. J. Mol. Biol. - published February 27, 2016
2. Pyle AM, Schlick T
Crystal structure of FhuD at 1.6 Å resolution: a ferrichrome-binding protein from the animal and human pathogen Staphylococcus pseudintermedius.
1. Acta Crystallogr F Struct Biol Commun - published February 27, 2016
2. Abate F, Cozzi R, Maritan M, Lo Surdo P, Maione D, Malito E, Bottomley MJ
When your cap matters: structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins.
1. Curr. Opin. Struct. Biol. - published February 27, 2016
2. Leung DW, Amarasinghe GK
Review: The lord of the rings: Structure and mechanism of the sliding clamp loader.
1. Biopolymers - published February 27, 2016
2. Kelch BA
Envelope Structures of Gram-Positive Bacteria.
1. Curr. Top. Microbiol. Immunol. - published February 27, 2016
2. Rajagopal M, Walker S
β-Subunit Binding Is Sufficient for Ligands to Open the Integrin αIIbβ3 Headpiece.
1. J. Biol. Chem. - published February 26, 2016
2. Lin FY, Zhu J, Eng ET, Hudson NE, Springer TA
The solution structure of the kallikrein-related peptidases inhibitor SPINK6.
1. Biochem. Biophys. Res. Commun. - published February 26, 2016
2. Jung S, Fischer J, Spudy B, Kerkow T, Sönnichsen FD, Xue L, Bonvin AM, Goettig P, Magdolen V, Meyer-Hoffert U, Grötzinger J
Investigating the Impact of Polymer Functional Groups on the Stability and Activity of Lysozyme-Polymer Conjugates.
1. Biomacromolecules - published February 26, 2016
2. Lucius M, Falatach R, McGlone C, Makaroff K, Danielson A, Williams C, Nix JC, Konkolewicz D, Page RC, Berberich JA
Directed evolution of G protein-coupled receptors in yeast for higher functional production in eukaryotic expression hosts.
1. Sci Rep - published February 26, 2016
2. Schütz M, Schöppe J, Sedlák E, Hillenbrand M, Nagy-Davidescu G, Ehrenmann J, Klenk C, Egloff P, Kummer L, Plückthun A
The Bub1-Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation.
1. Nat Commun - published February 26, 2016
2. Jia L, Li B, Yu H
Nucleic Acid Binding by Mason-Pfizer Monkey Virus CA Promotes Virus Assembly and Genome Packaging.
1. J. Virol. - published February 26, 2016
2. Füzik T, Píchalová R, Schur FK, Strohalmová K, Křížová I, Hadravová R, Rumlová M, Briggs JA, Ulbrich P, Ruml T
PP2A as a master regulator of the cell cycle.
1. Crit Rev Biochem Mol Biol - published February 25, 2016
2. Wlodarchak N, Xing Y
Investigating the Role of Artemin Glycosylation.
1. Pharm. Res. - published February 25, 2016
2. Danwen Q, Code C, Quan C, Gong BJ, Arndt J, Pepinsky B, Rand KD, Houde D
Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes.
1. J. Immunol. Methods - published February 25, 2016
2. Hellman LM, Yin L, Wang Y, Blevins SJ, Riley TP, Belden OS, Spear TT, Nishimura MI, Stern LJ, Baker BM
Structural and molecular basis for Ebola virus neutralization by protective human antibodies.
1. Science - published February 25, 2016
2. Misasi J, Gilman MS, Kanekiyo M, Gui M, Cagigi A, Mulangu S, Corti D, Ledgerwood JE, Lanzavecchia A, Cunningham J, Muyembe-Tamfun JJ, Baxa U, Graham BS, Xiang Y, Sullivan NJ, McLellan JS
Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods.
1. J. Med. Chem. - published February 24, 2016
2. Pelz NF, Bian Z, Zhao B, Shaw S, Tarr JC, Belmar J, Gregg C, Camper DV, Goodwin CM, Arnold AL, Sensintaffar JL, Friberg A, Rossanese OW, Lee T, Olejniczak ET, Fesik SW
Identification and characterization of a novel broad spectrum virus entry inhibitor.
1. J. Virol. - published February 24, 2016
2. Chou YY, Cuevas C, Carocci M, Stubbs SH, Ma M, Cureton DK, Chao L, Evesson F, He K, Yang PL, Whelan SP, Ross SR, Kirchhausen T, Gaudin R
Domain organization of vaccinia virus helicase-primase D5.
1. J. Virol. - published February 24, 2016
2. Hutin S, Ling WL, Round A, Effantin G, Reich S, Iseni F, Tarbouriech N, Schoehn G, Burmeister WP
An Essential Role for Cdc42 in the Functioning of the Adult Mammary Gland.
1. J. Biol. Chem. - published February 24, 2016
2. Druso JE, Endo M, Lin MC, Peng X, Antonyak MA, Meller S, Cerione RA
Allosteric Inhibition of Bcr-Abl Kinase by High-Affinity Monobody Inhibitors Directed to the SH2-Kinase Interface.
1. J. Biol. Chem. - published February 24, 2016
2. Wojcik J, Lamontanara AJ, Grabe G, Koide A, Akin L, Gerig B, Hantschel O, Koide S
Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation.
1. PLoS ONE - published February 23, 2016
2. Jung B, Padula D, Burtscher I, Landerer C, Lutter D, Theis F, Messias AC, Geerlof A, Sattler M, Kremmer E, Boldt K, Ueffing M, Lickert H
Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice.
1. Transl Res - published February 23, 2016
2. Liu CL, Wang Y, Liao M, Santos MM, Fernandes C, Sukhova GK, Zhang JY, Cheng X, Yang C, Huang X, Levy B, Libby P, Wu G, Shi GP
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human α(IIb)β(3) Integrin Complexes.
1. Biophys. J. - published February 23, 2016
2. Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes.
1. J. Mol. Biol. - published February 22, 2016
2. van Zundert GC, Rodrigues JP, Trellet M, Schmitz C, Kastritis PL, Karaca E, Melquiond AS, van Dijk M, de Vries SJ, Bonvin AM
Grafting PMMA Brushes from α-Alumina Nanoparticles via SI-ATRP.
1. ACS Appl Mater Interfaces - published February 22, 2016
2. Khabibullin A, Bhangaonkar K, Mahoney C, Lu Z, Schmitt M, Sekizkardes AK, Bockstaller MR, Matyjaszewski K
Insights into the gate and scaffold of the nuclear pore complex.
1. Nucleus - published February 22, 2016
2. Zwerger M, Eibauer M, Medalia O
Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation.
1. J. Cell Biol. - published February 22, 2016
2. Squarr AJ, Brinkmann K, Chen B, Steinbacher T, Ebnet K, Rosen MK, Bogdan S
Synthetic Human TLR9-LRR11 Peptide Attenuates TLR9 Signaling by Binding to and thus Decreasing Internalization of CpG Oligodeoxynucleotides.
1. Int J Mol Sci - published February 22, 2016
2. Pan X, Li B, Kuang M, Liu X, Cen Y, Qin R, Ding G, Zheng J, Zhou H
Characterization of L1-Ribonucleoprotein Particles.
1. Methods Mol Biol - published February 20, 2016
2. Taylor MS, LaCava J, Dai L, Mita P, Burns KH, Rout MP, Boeke JD
Improving Patient Experience and Primary Care Quality for Patients With Complex Chronic Disease Using the Electronic Patient-Reported Outcomes Tool: Adopting Qualitative Methods Into a User-Centered Design Approach.
1. JMIR Res Protoc - published February 20, 2016
2. Steele Gray C, Khan AI, Kuluski K, McKillop I, Sharpe S, Bierman AS, Lyons RF, Cott C
Atomic resolution experimental phase information reveals extensive disorder and bound 2-methyl-2,4-pentanediol in Ca(2+)-calmodulin.
1. Acta Crystallogr D Struct Biol - published February 20, 2016
2. Lin J, van den Bedem H, Brunger AT, Wilson MA
Reversible Bergman cyclization by atomic manipulation.
1. Nat Chem - published February 20, 2016
2. Schuler B, Fatayer S, Mohn F, Moll N, Pavliček N, Meyer G, Peña D, Gross L
Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects.
1. Acta Crystallogr D Struct Biol - published February 20, 2016
2. Reichen C, Madhurantakam C, Hansen S, Grütter MG, Plückthun A, Mittl PR
High-density grids for efficient data collection from multiple crystals.
1. Acta Crystallogr D Struct Biol - published February 20, 2016
2. Baxter EL, Aguila L, Alonso-Mori R, Barnes CO, Bonagura CA, Brehmer W, Brunger AT, Calero G, Caradoc-Davies TT, Chatterjee R, Degrado WF, Fraser JS, Ibrahim M, Kern J, Kobilka BK, Kruse AC, Larsson KM, Lemke HT, Lyubimov AY, Manglik A, McPhillips SE, Norgren E, Pang SS, Soltis SM, Song J, Thomaston J, Tsai Y, Weis WI, Woldeyes RA, Yachandra V, Yano J, Zouni A, Cohen AE
The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex.
1. ACS Chem. Biol. - published February 19, 2016
2. Syeda SS, Carlson EJ, Miller MR, Francis R, Clapham DE, Lishko PV, Hawkinson JE, Hook D, Georg GI
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage.
1. Science - published February 19, 2016
2. Jiang F, Taylor DW, Chen JS, Kornfeld JE, Zhou K, Thompson AJ, Nogales E, Doudna JA
A generic selection system for improved expression and thermostability of G protein-coupled receptors by directed evolution.
1. Sci Rep - published February 19, 2016
2. Klenk C, Ehrenmann J, Schütz M, Plückthun A
What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira.
1. PLoS Negl Trop Dis - published February 19, 2016
2. Fouts DE, Matthias MA, Adhikarla H, Adler B, Amorim-Santos L, Berg DE, Bulach D, Buschiazzo A, Chang YF, Galloway RL, Haake DA, Haft DH, Hartskeerl R, Ko AI, Levett PN, Matsunaga J, Mechaly AE, Monk JM, Nascimento AL, Nelson KE, Palsson B, Peacock SJ, Picardeau M, Ricaldi JN, Thaipandungpanit J, Wunder EA, Yang XF, Zhang JJ, Vinetz JM
Erratum to: Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris.
1. J. Biomol. NMR - published February 19, 2016
2. Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM
Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor.
1. Mol. Cell - published February 18, 2016
2. Fu Q, Fu TM, Cruz AC, Sengupta P, Thomas SK, Wang S, Siegel RM, Wu H, Chou JJ
Magic Acts with the Cohesin Ring.
1. Mol. Cell - published February 18, 2016
2. Yu H
The Different Conformational States of Tissue Transglutaminase Have Opposing Affects on Cell Viability.
1. J. Biol. Chem. - published February 18, 2016
2. Singh G, Zhang J, Ma Y, Cerione RA, Antonyak MA
Membrane Protein Mobility and Orientation Preserved in Supported Bilayers Created Directly from Cell Plasma Membrane Blebs.
1. Langmuir - published February 17, 2016
2. Richards MJ, Hsia CY, Singh RR, Haider H, Kumpf J, Kawate T, Daniel S
Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI.
1. ChemMedChem - published February 17, 2016
2. Jarvis C, Han Z, Kalas V, Klein R, Pinkner JS, Ford B, Binkley J, Cusumano CK, Cusumano Z, Mydock-McGrane L, Hultgren SJ, Janetka JW
IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity.
1. Sci Rep - published February 17, 2016
2. Avnir Y, Watson CT, Glanville J, Peterson EC, Tallarico AS, Bennett AS, Qin K, Fu Y, Huang CY, Beigel JH, Breden F, Zhu Q, Marasco WA
Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction.
1. Nature - published February 17, 2016
2. Nishikawa JL, Boeszoermenyi A, Vale-Silva LA, Torelli R, Posteraro B, Sohn YJ, Ji F, Gelev V, Sanglard D, Sanguinetti M, Sadreyev RI, Mukherjee G, Bhyravabhotla J, Buhrlage SJ, Gray NS, Wagner G, Näär AM, Arthanari H
KRAS Engages AGO2 to Enhance Cellular Transformation.
1. Cell Rep - published February 16, 2016
2. Shankar S, Pitchiaya S, Malik R, Kothari V, Hosono Y, Yocum AK, Gundlapalli H, White Y, Firestone A, Cao X, Dhanasekaran SM, Stuckey JA, Bollag G, Shannon K, Walter NG, Kumar-Sinha C, Chinnaiyan AM
Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein.
1. Proc. Natl. Acad. Sci. U.S.A. - published February 16, 2016
2. Chen Y, Seepersaud R, Bensing BA, Sullam PM, Rapoport TA
The histone chaperone Nap1 is a major regulator of histone H2A-H2B dynamics at the inducible GAL locus.
1. Mol. Cell. Biol. - published February 16, 2016
2. Chen X, D'Arcy S, Radebaugh CA, Krzizike DD, Giebler HA, Huang L, Nyborg JK, Luger K, Stargell LA
Identification of a Substrate Recognition Domain in the Replication Stress Response Protein Zinc Finger Ran-binding Domain Containing Protein 3 (ZRANB3).
1. J. Biol. Chem. - published February 16, 2016
2. Badu-Nkansah A, Mason AC, Eichman BF, Cortez D
Multi-ion free energy landscapes underscore the microscopic mechanism of ion selectivity in the KcsA channel.
1. Biochim. Biophys. Acta - published February 16, 2016
2. Medovoy D, Perozo E, Roux B
The zebrafish pinball wizard gene encodes WRB, a tail-anchored-protein receptor essential for inner-ear hair cells and retinal photoreceptors.
1. J. Physiol. (Lond.) - published February 15, 2016
2. Lin SY, Vollrath MA, Mangosing S, Shen J, Cardenas E, Corey DP
A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance.
1. J. Mol. Biol. - published February 13, 2016
2. Jiang L, Liu P, Bank C, Renzette N, Prachanronarong K, Yilmaz LS, Caffrey DR, Zeldovich KB, Schiffer CA, Kowalik TF, Jensen JD, Finberg RW, Wang JP, Bolon DN
Peptide mini-scaffold facilitates JNK3 activation in cells.
1. Sci Rep - published February 13, 2016
2. Zhan X, Stoy H, Kaoud TS, Perry NA, Chen Q, Perez A, Els-Heindl S, Slagis JV, Iverson TM, Beck-Sickinger AG, Gurevich EV, Dalby KN, Gurevich VV
Chronic Recurrent Pseudophakic Endophthalmitis.
1. JAMA Ophthalmol - published February 13, 2016
2. Chin EK, Almeida DR, Mahajan VB
Trastuzumab-Resistant Luminal B Breast Cancer Cells Show Basal-Like Cell Growth Features Through NF-κB-Activation.
1. Monoclon Antib Immunodiagn Immunother - published February 13, 2016
2. Kanzaki H, Mukhopadhya NK, Cui X, Ramanujan VK, Murali R
Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4 + T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity.
1. EBioMedicine - published February 13, 2016
2. Richard J, Veillette M, Ding S, Zoubchenok D, Alsahafi N, Coutu M, Brassard N, Park J, Courter JR, Melillo B, Smith AB, Shaw GM, Hahn BH, Sodroski J, Kaufmann DE, Finzi A
Introduction of a polar core into the de novo designed protein Top7.
1. Protein Sci. - published February 13, 2016
2. Basanta B, Chan KK, Barth P, King T, Hinshaw JR, Sosnick TR, Liu G, Everett J, Xiao R, Montelione GT, Baker D
Recurrent Recessive Mutation in DGUOK Causes Idiopathic Non-Cirrhotic Portal Hypertension.
1. Hepatology - published February 13, 2016
2. Vilarinho S, Sari S, Yilmaz G, Stiegler AL, Boggon TJ, Jain D, Akyol G, Dalgic B, Günel M, Lifton RP
Structural basis for histone H2B deubiquitination by the SAGA DUB module.
1. Science - published February 12, 2016
2. Morgan MT, Haj-Yahya M, Ringel AE, Bandi P, Brik A, Wolberger C
Topologically Diverse Human Membrane Proteins Partition to Liquid-Disordered Domains in Phase-Separated Lipid Vesicles.
1. Biochemistry - published February 11, 2016
2. Schlebach JP, Barrett PJ, Day CA, Kim JH, Kenworthy AK, Sanders CR
New insights into the mechanism of substrates trafficking in Glyoxylate/Hydroxypyruvate reductases.
1. Sci Rep - published February 11, 2016
2. Lassalle L, Engilberge S, Madern D, Vauclare P, Franzetti B, Girard E
Asthma Associates With Human Abdominal Aortic Aneurysm and Rupture.
1. Arterioscler. Thromb. Vasc. Biol. - published February 11, 2016
2. Liu CL, Wemmelund H, Wang Y, Liao M, Lindholt JS, Johnsen SP, Vestergaard H, Fernandes C, Sukhova GK, Cheng X, Zhang JY, Yang C, Huang X, Daugherty A, Levy BD, Libby P, Shi GP
Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break upon Gating.
1. Cell - published February 11, 2016
2. Matthies D, Dalmas O, Borgnia MJ, Dominik PK, Merk A, Rao P, Reddy BG, Islam S, Bartesaghi A, Perozo E, Subramaniam S
Comparison of microbiology and visual outcomes of patients undergoing small-gauge and 20-gauge vitrectomy for endophthalmitis.
1. Clin Ophthalmol - published February 10, 2016
2. Almeida DR, Chin EK, Shah SS, Bakall B, Gehrs KM, Boldt HC, Russell SR, Folk JC, Mahajan VB
Nuclear magnetic resonance analysis of the conformational state of cancer mutant of fibroblast growth factor receptor 1 tyrosine kinase domain.
1. Genes Cells - published February 10, 2016
2. Kobashigawa Y, Amano S, Yoza K, Himeno R, Amemiya S, Morioka H, Yokogawa M, Kumeta H, Schlessinger J, Inagaki F
Graded Control of Microtubule Severing by Tubulin Glutamylation.
1. Cell - published February 10, 2016
2. Valenstein ML, Roll-Mecak A
Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins.
1. Cell Rep - published February 10, 2016
2. Edwards MR, Liu G, Mire CE, Sureshchandra S, Luthra P, Yen B, Shabman RS, Leung DW, Messaoudi I, Geisbert TW, Amarasinghe GK, Basler CF
Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering.
1. ACS Chem. Biol. - published February 9, 2016
2. Nuñez JK, Harrington LB, Doudna JA
Isotope effect analyses provide evidence for an altered transition state for RNA 2'-O-transphosphorylation catalyzed by Zn(2.)
1. Chem. Commun. (Camb.) - published February 9, 2016
2. Zhang S, Gu H, Chen H, Strong E, Ollie EW, Kellerman D, Liang D, Miyagi M, Anderson VE, Piccirilli JA, York DM, Harris ME
Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation.
1. Proc. Natl. Acad. Sci. U.S.A. - published February 9, 2016
2. Hattori T, Lai D, Dementieva IS, Montaño SP, Kurosawa K, Zheng Y, Akin LR, Świst-Rosowska KM, Grzybowski AT, Koide A, Krajewski K, Strahl BD, Kelleher NL, Ruthenburg AJ, Koide S
Tuned by metals: the TET peptidase activity is controlled by 3 metal binding sites.
1. Sci Rep - published February 8, 2016
2. Colombo M, Girard E, Franzetti B
A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase.
1. Proc. Natl. Acad. Sci. U.S.A. - published February 8, 2016
2. Debler EW, Jain K, Warmack RA, Feng Y, Clarke SG, Blobel G, Stavropoulos P
WrpA is an atypical flavodoxin-family protein under regulatory control of the Brucella abortus general stress response system.
1. J. Bacteriol. - published February 8, 2016
2. Herrou J, Czyż DM, Willett JW, Kim HS, Chhor G, Babnigg G, Kim Y, Crosson S
Early and multiple origins of metastatic lineages within primary tumors.
1. Proc. Natl. Acad. Sci. U.S.A. - published February 8, 2016
2. Zhao ZM, Zhao B, Bai Y, Iamarino A, Gaffney SG, Schlessinger J, Lifton RP, Rimm DL, Townsend JP
Structural Basis for the Unique Multivalent Readout of Unmodified H3 Tail by Arabidopsis ORC1b BAH-PHD Cassette.
1. Structure - published February 8, 2016
2. Li S, Yang Z, Du X, Liu R, Wilkinson AW, Gozani O, Jacobsen SE, Patel DJ, Du J
Exploiting dominant-negative toxins to combat Staphylococcus aureus pathogenesis.
1. EMBO Rep. - published February 8, 2016
2. Reyes-Robles T, Lubkin A, Alonzo F, Lacy DB, Torres VJ
Rational design of DNA-actuated enzyme nanoreactors guided by single molecule analysis.
1. Nanoscale - published February 7, 2016
2. Dhakal S, Adendorff MR, Liu M, Yan H, Bathe M, Walter NG
Structural characterization of GASDALIE Fc bound to the activating Fc receptor FcγRIIIa.
1. J. Struct. Biol. - published February 7, 2016
2. Ahmed AA, Keremane SR, Vielmetter J, Bjorkman PJ
The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress.
1. PLoS Genet. - published February 6, 2016
2. Buser R, Kellner V, Melnik A, Wilson-Zbinden C, Schellhaas R, Kastner L, Piwko W, Dees M, Picotti P, Maric M, Labib K, Luke B, Peter M
Precision Medicine: Personalized Proteomics for the Diagnosis and Treatment of Idiopathic Inflammatory Disease.
1. JAMA Ophthalmol - published February 6, 2016
2. Velez G, Roybal CN, Colgan D, Tsang SH, Bassuk AG, Mahajan VB
gH/gL supercomplexes at early stages of herpesvirus entry.
1. Curr Opin Virol - published February 6, 2016
2. Heldwein EE
Implementing an Integrated Health Protection/Health Promotion Intervention in the Hospital Setting: Lessons Learned From the Be Well, Work Well Study.
1. J. Occup. Environ. Med. - published February 6, 2016
2. Sorensen G, Nagler EM, Hashimoto D, Dennerlein JT, Theron JV, Stoddard AM, Buxton O, Wallace LM, Kenwood C, Nelson CC, Tamers SL, Grant MP, Wagner G
Advancing multiscale structural mapping of the brain through fluorescence imaging and analysis across length scales.
1. Interface Focus - published February 6, 2016
2. Hogstrom LJ, Guo SM, Murugadoss K, Bathe M
Filament assemblies in foreign nucleic acid sensors.
1. Curr. Opin. Struct. Biol. - published February 6, 2016
2. Sohn J, Hur S
L1CAM is an independent predictor of poor survival in endometrial cancer - An analysis of The Cancer Genome Atlas (TCGA).
1. Gynecol. Oncol. - published February 6, 2016
2. Dellinger TH, Smith DD, Ouyang C, Warden CD, Williams JC, Han ES
Binding of the Covalent Flavin Assembly Factor to the Flavoprotein Subunit of Complex II.
1. J. Biol. Chem. - published February 5, 2016
2. Maklashina E, Rajagukguk S, Starbird CA, McDonald WH, Koganitsky A, Eisenbach M, Iverson TM, Cecchini G
Accurate Prediction of Contact Numbers for Multi-Spanning Helical Membrane Proteins.
1. J Chem Inf Model - published February 5, 2016
2. Li B, Mendenhall J, Nguyen ED, Weiner BE, Fischer AW, Meiler J
Assembly mechanism of Trypanosoma brucei BILBO1 at the flagellar pocket collar.
1. Commun Integr Biol - published February 5, 2016
2. Vidilaseris K, Lesigang J, Morriswood B, Dong G
Waltzing around cofactors.
1. Elife - published February 5, 2016
2. Chen PY, Wittenborn EC, Drennan CL
Prevalence of Diabetes and Health-Related Quality of Life Among Rural-to-Urban Nong Zhuan Fei Migrants in an Urban Area of Northern China, 2013.
1. Public Health Rep - published February 5, 2016
2. Yan S, Hong X, Yu H, Yang Z, Liu S, Quan W, Xu J, Zhu L, Cheng W, Xiao H, Kitzman-Ulrich H, DeHaven MJ
Naturally Produced Defensive Alkenal Compounds Activate TRPA1.
1. Chem. Senses - published February 5, 2016
2. Blair NT, Philipson BI, Richards PM, Doerner JF, Segura A, Silver WL, Clapham DE
CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites.
1. J. Mol. Biol. - published February 5, 2016
2. Cimermancic P, Weinkam P, Rettenmaier TJ, Bichmann L, Keedy DA, Woldeyes RA, Schneidman-Duhovny D, Demerdash ON, Mitchell JC, Wells JA, Fraser JS, Sali A
RNA recognition by Roquin in posttranscriptional gene regulation.
1. Wiley Interdiscip Rev RNA - published February 4, 2016
2. Schlundt A, Niessing D, Heissmeyer V, Sattler M
Preparation and Characterization of Stable α-Synuclein Lipoprotein Particles.
1. J. Biol. Chem. - published February 4, 2016
2. Eichmann C, Campioni S, Kowal J, Maslennikov I, Gerez J, Liu X, Verasdonck J, Nespovitaya N, Choe S, Meier BH, Picotti P, Rizo J, Stahlberg H, Riek R
Protein Structural Memory Influences Ligand Binding Mode(s) and Unbinding Rates.
1. J Chem Theory Comput - published February 3, 2016
2. Xu M, Caflisch A, Hamm P
Models of human core transcriptional regulatory circuitries.
1. Genome Res. - published February 3, 2016
2. Saint-André V, Federation AJ, Lin CY, Abraham BJ, Reddy J, Lee TI, Bradner JE, Young RA
Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs.
1. Structure - published February 2, 2016
2. Dominik PK, Borowska MT, Dalmas O, Kim SS, Perozo E, Keenan RJ, Kossiakoff AA
Sensing of latent EBV infection through exosomal transfer of 5'pppRNA.
1. Proc Natl Acad Sci U S A - published February 2, 2016
2. Baglio SR, van Eijndhoven MA, Koppers-Lalic D, Berenguer J, Lougheed SM, Gibbs S, Léveillé N, Rinkel RN, Hopmans ES, Swaminathan S, Verkuijlen SA, Scheffer GL, van Kuppeveld FJ, de Gruijl TD, Bultink IE, Jordanova ES, Hackenberg M, Piersma SR, Knol JC, Voskuyl AE, Wurdinger T, Jiménez CR, Middeldorp JM, Pegtel DM
Hybrid Structural Analysis of the Arp2/3 Regulator Arpin Identifies Its Acidic Tail as a Primary Binding Epitope.
1. Structure - published February 2, 2016
2. Fetics S, Thureau A, Campanacci V, Aumont-Nicaise M, Dang I, Gautreau A, Pérez J, Cherfils J
Enterovirus D68 receptor requirements unveiled by haploid genetics.
1. Proc Natl Acad Sci U S A - published February 2, 2016
2. Baggen J, Thibaut HJ, Staring J, Jae LT, Liu Y, Guo H, Slager JJ, de Bruin JW, van Vliet AL, Blomen VA, Overduin P, Sheng J, de Haan CA, de Vries E, Meijer A, Rossmann MG, Brummelkamp TR, van Kuppeveld FJ
An improved fluorogenic assay for SIRT1, SIRT2, and SIRT3.
1. Org Biomol Chem - published February 2, 2016
2. Chiang YL, Lin H
Crystal Structure of a Ube2S-Ubiquitin Conjugate.
1. PLoS ONE - published February 2, 2016
2. Lorenz S, Bhattacharyya M, Feiler C, Rape M, Kuriyan J
SPLINTS: small-molecule protein ligand interface stabilizers.
1. Curr. Opin. Struct. Biol. - published February 2, 2016
2. Fischer ES, Park E, Eck MJ, Thomä NH
Fibrinogen Release and Deposition on Urinary Catheters Placed during Urological Procedures.
1. J. Urol. - published February 2, 2016
2. Flores-Mireles AL, Walker JN, Bauman TM, Potretzke AM, Schreiber HL, Park AM, Pinkner JS, Caparon MG, Hultgren SJ, Desai A
3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012.
1. Virology - published February 2, 2016
2. Johnson RF, Bagci U, Keith L, Tang X, Mollura DJ, Zeitlin L, Qin J, Huzella L, Bartos CJ, Bohorova N, Bohorov O, Goodman C, Kim do H, Paulty MH, Velasco J, Whaley KJ, Johnson JC, Pettitt J, Ork BL, Solomon J, Oberlander N, Zhu Q, Sun J, Holbrook MR, Olinger GG, Baric RS, Hensley LE, Jahrling PB, Marasco WA
Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
1. Elife - published February 2, 2016
2. Fanning SW, Mayne CG, Dharmarajan V, Carlson KE, Martin TA, Novick SJ, Toy W, Green B, Panchamukhi S, Katzenellenbogen BS, Tajkhorshid E, Griffin PR, Shen Y, Chandarlapaty S, Katzenellenbogen JA, Greene GL
Structural Mechanism for the Fidelity Modulation of DNA Polymerase λ.
1. J. Am. Chem. Soc. - published February 2, 2016
2. Liu MS, Tsai HY, Liu XX, Ho MC, Wu WJ, Tsai MD
Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli.
1. Nature - published February 2, 2016
2. Hayes RP, Xiao Y, Ding F, van Erp PB, Rajashankar K, Bailey S, Wiedenheft B, Ke A
Structure and Engineering of Francisella novicida Cas9.
1. Cell - published February 2, 2016
2. Hirano H, Gootenberg JS, Horii T, Abudayyeh OO, Kimura M, Hsu PD, Nakane T, Ishitani R, Hatada I, Zhang F, Nishimasu H, Nureki O
Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase.
1. mBio - published February 2, 2016
2. Smith P, Ho CK, Takagi Y, Djaballah H, Shuman S
Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies.
1. mBio - published February 2, 2016
2. Bornholdt ZA, Ndungo E, Fusco ML, Bale S, Flyak AI, Crowe JE Jr, Chandran K, Saphire EO
Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation.
1. Cell - published February 2, 2016
2. Arrigoni C, Rohaim A, Shaya D, Findeisen F, Stein RA, Nurva SR, Mishra S, Mchaourab HS, Minor DL Jr
Assembly, molecular organization, and membrane-binding properties of development-specific septins.
1. J Cell Biol - published February 2, 2016
2. Garcia G 3rd, Finnigan GC, Heasley LR, Sterling SM, Aggarwal A, Pearson CG, Nogales E, McMurray MA, Thorner J
Slam is an outer membrane protein that is required for the surface display of lipidated virulence factors in Neisseria.
1. Nat Microbiol - published February 2, 2016
2. Hooda Y, Lai CC, Judd A, Buckwalter CM, Shin HE, Gray-Owen SD, Moraes TF
Defective mutations within the translocation domain of Clostridium difficile toxin B impair disease pathogenesis.
1. Pathog Dis - published February 1, 2016
2. Hamza T, Zhang Z, Melnyk RA, Feng H
Single-particle cryo-EM data acquisition by using direct electron detection camera.
1. Microscopy (Oxf) - published February 1, 2016
2. Wu S, Armache JP, Cheng Y
Relative Rates of Amino Acid Import via the ABC Transporter GlnPQ Determine the Growth Performance of Lactococcus lactis.
1. J Bacteriol - published February 1, 2016
2. Fulyani F, Schuurman-Wolters GK, Slotboom DJ, Poolman B
Inhibition of Pseudomonas aeruginosa ExsA DNA-Binding Activity by N-Hydroxybenzimidazoles.
1. Antimicrob Agents Chemother - published February 1, 2016
2. Marsden AE, King JM, Spies MA, Kim OK, Yahr TL
Conformational dynamics of Ca2+-dependent responses in the polycystin-2 C-terminal tail.
1. Biochem. J. - published February 1, 2016
2. Yang Y, Hodsdon ME, Lolis EJ, Ehrlich BE
Itinerary of high density lipoproteins in endothelial cells.
1. Biochim Biophys Acta - published February 1, 2016
2. Perisa D, Rohrer L, Kaech A, von Eckardstein A
Stereocontrol within polyketide assembly lines.
1. Nat Prod Rep - published February 1, 2016
2. Keatinge-Clay AT
Pnu Transporters: Ain't They SWEET?
1. Trends Biochem Sci - published February 1, 2016
2. Jaehme M, Guskov A, Slotboom DJ
Principles of cryo-EM single-particle image processing.
1. Microscopy (Oxf) - published February 1, 2016
2. Sigworth FJ
Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase.
1. J Am Chem Soc - published February 1, 2016
2. Bourne Y, Sharpless KB, Taylor P, Marchot P
Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations.
1. Mol Immunol - published February 1, 2016
2. Hicar MD, Chen X, Kalams SA, Sojar H, Landucci G, Forthal DN, Spearman P, Crowe JE Jr
Well-Defined Macromolecules Using Horseradish Peroxidase as a RAFT Initiase.
1. Macromol Rapid Commun - published February 1, 2016
2. Danielson AP, Bailey-Van Kuren D, Lucius ME, Makaroff K, Williams C, Page RC, Berberich JA, Konkolewicz D
Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel.
1. J Med Chem - published February 1, 2016
2. Li F, Ma C, DeGrado WF, Wang J
Immunogenicity and efficacy of alphavirus-derived replicon vaccines for respiratory syncytial virus and human metapneumovirus in nonhuman primates.
1. Vaccine - published February 1, 2016
2. Bates JT, Pickens JA, Schuster JE, Johnson M, Tollefson SJ, Williams JV, Davis NL, Johnston RE, Schultz-Darken N, Slaughter JC, Smith-House F, Crowe JE Jr
The role of ATP-dependent machines in regulating genome topology.
1. Curr. Opin. Struct. Biol. - published February 1, 2016
2. Hauk G, Berger JM
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.
1. Nat. Genet. - published February 1, 2016
2. Bandopadhayay P, Ramkissoon LA, Jain P, Bergthold G, Wala J, Zeid R, Schumacher SE, Urbanski L, O'Rourke R, Gibson WJ, Pelton K, Ramkissoon SH, Han HJ, Zhu Y, Choudhari N, Silva A, Boucher K, Henn RE, Kang YJ, Knoff D, Paolella BR, Gladden-Young A, Varlet P, Pages M, Horowitz PM, Federation A, Malkin H, Tracy AA, Seepo S, Ducar M, Van Hummelen P, Santi M, Buccoliero AM, Scagnet M, Bowers DC, Giannini C, Puget S, Hawkins C, Tabori U, Klekner A, Bognar L, Burger PC, Eberhart C, Rodriguez FJ, Hill DA, Mueller S, Haas-Kogan DA, Phillips JJ, Santagata S, Stiles CD, Bradner JE, Jabado N, Goren A, Grill J, Ligon AH, Goumnerova L, Waanders AJ, Storm PB, Kieran MW, Ligon KL, Beroukhim R, Resnick AC
An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma.
1. Nat. Genet. - published February 1, 2016
2. Drier Y, Cotton MJ, Williamson KE, Gillespie SM, Ryan RJ, Kluk MJ, Carey CD, Rodig SJ, Sholl LM, Afrogheh AH, Faquin WC, Queimado L, Qi J, Wick MJ, El-Naggar AK, Bradner JE, Moskaluk CA, Aster JC, Knoechel B, Bernstein BE
Improving quantitative structure-activity relationship models using Artificial Neural Networks trained with dropout.
1. J. Comput. Aided Mol. Des. - published February 1, 2016
2. Mendenhall J, Meiler J
Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin.
1. J. Biol. Chem. - published February 1, 2016
2. Bensing BA, Loukachevitch LV, McCulloch KM, Yu H, Vann KR, Wawrzak Z, Anderson S, Chen X, Sullam PM, Iverson TM
RNA-activated DNA cleavage by the Type III-B CRISPR-Cas effector complex.
1. Genes Dev - published February 1, 2016
2. Estrella MA, Kuo FT, Bailey S
Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism.
1. Biochem Soc Trans - published February 1, 2016
2. Malabanan MM, Blind RD
Structure- and function-based design of Plasmodium-selective proteasome inhibitors.
1. Nature - published February 1, 2016
2. Li H, O'Donoghue AJ, van der Linden WA, Xie SC, Yoo E, Foe IT, Tilley L, Craik CS, da Fonseca PC, Bogyo M
Developing genetic tools to exploit Chaetomium thermophilum for biochemical analyses of eukaryotic macromolecular assemblies.
1. Sci Rep - published February 1, 2016
2. Kellner N, Schwarz J, Sturm M, Fernandez-Martinez J, Griesel S, Zhang W, Chait BT, Rout MP, Kück U, Hurt E
Let It Go and Open Up, an Ensemble of Ion Channel Active States.
1. Cell - published February 1, 2016
2. Minor DL Jr
Dynamic Remodeling of the Magnetosome Membrane Is Triggered by the Initiation of Biomineralization.
1. mBio - published February 1, 2016
2. Cornejo E, Subramanian P, Li Z, Jensen GJ, Komeili A
Interactome Mapping Reveals the Evolutionary History of the Nuclear Pore Complex.
1. PLoS Biol - published February 1, 2016
2. Obado SO, Brillantes M, Uryu K, Zhang W, Ketaren NE, Chait BT, Field MC, Rout MP
Structural biology. Cas9, poised for DNA cleavage.
1. Science - published February 1, 2016
2. Chen H, Bailey S
Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections.
1. Microbiol Spectr - published February 1, 2016
2. O'Brien VP, Hannan TJ, Nielsen HV, Hultgren SJ