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121 Member Publications for January 2016

Towards a structural understanding of RNA synthesis by negative strand RNA viral polymerases.
1. Curr. Opin. Struct. Biol. - published January 31, 2016
2. Reguera J, Gerlach P, Cusack S
Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3.
1. J. Biol. Chem. - published January 29, 2016
2. Floor SN, Condon KJ, Sharma D, Jankowsky E, Doudna JA
Improved Accuracy from Joint X-ray and NMR Refinement of a Protein-RNA Complex Structure.
1. J. Am. Chem. Soc. - published January 29, 2016
2. Carlon A, Ravera E, Hennig J, Parigi G, Sattler M, Luchinat C
Mobile Genetic Elements: In Silico, In Vitro, In Vivo.
1. Mol. Ecol. - published January 29, 2016
2. Arkhipova IR, Rice PA
Cholesterol modulates Orai1 channel function.
1. Sci Signal - published January 28, 2016
2. Derler I, Jardin I, Stathopulos PB, Muik M, Fahrner M, Zayats V, Pandey SK, Poteser M, Lackner B, Absolonova M, Schindl R, Groschner K, Ettrich R, Ikura M, Romanin C
Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity.
1. J. Med. Chem. - published January 28, 2016
2. Goodreid JD, Janetzko J, Santa Maria JP, Wong KS, Leung E, Eger BT, Bryson S, Pai EF, Gray-Owen SD, Walker S, Houry WA, Batey RA
Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes.
1. Cell - published January 28, 2016
2. Ng CT, Mendoza JL, Garcia KC, Oldstone MB
Cog-Wheel Octameric Structure of RS1, the Discoidin Domain Containing Retinal Protein Associated with X-Linked Retinoschisis.
1. PLoS ONE - published January 27, 2016
2. Bush M, Setiaputra D, Yip CK, Molday RS
Precision Medicine: Genetic Repair of Retinitis Pigmentosa in Patient-Derived Stem Cells.
1. Sci Rep - published January 27, 2016
2. Bassuk AG, Zheng A, Li Y, Tsang SH, Mahajan VB
The Tubulation Activity of a Fission Yeast F-BAR Protein Is Dispensable for Its Function in Cytokinesis.
1. Cell Rep - published January 26, 2016
2. McDonald NA, Takizawa Y, Feoktistova A, Xu P, Ohi MD, Vander Kooi CW, Gould KL
Structure of the Intermediate Filament-Binding Region of Desmoplakin.
1. PLoS ONE - published January 26, 2016
2. Kang H, Weiss TM, Bang I, Weis WI, Choi HJ
Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites.
1. Nat Commun - published January 26, 2016
2. Binolfi A, Limatola A, Verzini S, Kosten J, Theillet FX, Rose HM, Bekei B, Stuiver M, van Rossum M, Selenko P
Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon.
1. Nat Commun - published January 26, 2016
2. Jomaa A, Boehringer D, Leibundgut M, Ban N
Chloroquine attenuates LPS-mediated macrophage activation through miR-669n-regulated SENP6 protein translation.
1. Am J Transl Res - published January 26, 2016
2. Long Y, Liu X, Wang N, Zhou H, Zheng J
The Atg17-Atg31-Atg29 Complex Coordinates with Atg11 to Recruit the Vam7 SNARE and Mediate Autophagosome-Vacuole Fusion.
1. Curr. Biol. - published January 25, 2016
2. Liu X, Mao K, Yu AY, Omairi-Nasser A, Austin J, Glick BS, Yip CK, Klionsky DJ
Measuring Monomer-to-Filament Transition of MAVS as an In Vitro Activity Assay for RIG-I-Like Receptors.
1. Methods Mol. Biol. - published January 25, 2016
2. Wu B, Huoh YS, Hur S
Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation.
1. Proc. Natl. Acad. Sci. U.S.A. - published January 25, 2016
2. Craney A, Kelly A, Jia L, Fedrigo I, Yu H, Rape M
Reply to Fernandez-Marrero et al.: Role of BOK at the intersection of endoplasmic reticulum stress and apoptosis regulation.
1. Proc. Natl. Acad. Sci. U.S.A. - published January 25, 2016
2. Carpio MA, Michaud M, Zhou W, Fisher JK, Walensky LD, Katz SG
Isothermal Titration Calorimetry to Characterize Enzymatic Reactions.
1. Methods Enzymol - published January 23, 2016
2. Mazzei L, Ciurli S, Zambelli B
Measuring the Kinetics of Molecular Association by Isothermal Titration Calorimetry.
1. Meth. Enzymol. - published January 23, 2016
2. Vander Meulen KA, Horowitz S, Trievel RC, Butcher SE
De novo CD5+ Diffuse Large B-cell Lymphoma: Adverse outcomes with and without stem cell transplantation in a large, multi-center, rituximab treated cohort.
1. Am. J. Hematol. - published January 22, 2016
2. Alinari L, Gru A, Quinion C, Huang Y, Lozanski A, Lozanski G, Poston J, Venkataraman G, Oak E, Kreisel F, Park SI, Matthews S, Abramson JS, Iris Lim H, Martin P, Cohen JB, Evens A, Al-Mansour Z, Singavi A, Fenske TS, Blum KA
Nitrogen-detected TROSY yields comparable sensitivity to proton-detected TROSY for non-deuterated, large proteins under physiological salt conditions.
1. J. Biomol. NMR - published January 22, 2016
2. Takeuchi K, Arthanari H, Imai M, Wagner G, Shimada I
Modulations of DNA Contacts by Linker Histones and Post-translational Modifications Determine the Mobility and Modifiability of Nucleosomal H3 Tails.
1. Mol. Cell - published January 21, 2016
2. Stützer A, Liokatis S, Kiesel A, Schwarzer D, Sprangers R, Söding J, Selenko P, Fischle W
Alfred Goodman Gilman (1941-2015).
1. Nature - published January 21, 2016
2. Lefkowitz RJ
Small Molecule Inhibitors of Protein Arginine Methyltransferases.
1. Expert Opin Investig Drugs - published January 20, 2016
2. Hu H, Qian K, Ho MC, Zheng YG
A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter.
1. Nature - published January 20, 2016
2. Oldham ML, Hite RK, Steffen AM, Damko E, Li Z, Walz T, Chen J
Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
1. Proc. Natl. Acad. Sci. U.S.A. - published January 20, 2016
2. Blower TR, Williamson BH, Kerns RJ, Berger JM
Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase.
1. Proc. Natl. Acad. Sci. U.S.A. - published January 20, 2016
2. Aldred KJ, Blower TR, Kerns RJ, Berger JM, Osheroff N
Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity.
1. ACS Chem. Biol. - published January 19, 2016
2. Morgen M, Jöst C, Malz M, Janowski R, Niessing D, Klein CD, Gunkel N, Miller AK
Polyketide Ring Expansion Mediated by a Thioesterase, Chain Elongation and Cyclization Domain, in Azinomycin Biosynthesis: Characterization of AziB and AziG.
1. Biochemistry - published January 19, 2016
2. Mori S, Simkhada D, Zhang H, Erb MS, Zhang Y, Williams H, Fedoseyenko D, Russell WK, Kim D, Fleer N, Ealick SE, Watanabe CM
Purification and Structural Analysis of SUN and KASH Domain Proteins.
1. Meth. Enzymol. - published January 19, 2016
2. Esra Demircioglu F, Cruz VE, Schwartz TU
Purification and Structural Analysis of Desmoplakin.
1. Meth. Enzymol. - published January 19, 2016
2. Choi HJ, Weis WI
Diabetes and the Association of Postoperative Hyperglycemia With Clinical and Economic Outcomes in Cardiac Surgery.
1. Diabetes Care - published January 19, 2016
2. Greco G, Ferket BS, D'Alessandro DA, Shi W, Horvath KA, Rosen A, Welsh S, Bagiella E, Neill AE, Williams DL, Greenberg A, Browndyke JN, Gillinov AM, Mayer ML, Keim-Malpass J, Gupta LS, Hohmann SF, Gelijns AC, O'Gara PT, Moskowitz AJ
Cellular structural biology as revealed by cryo-electron tomography.
1. J. Cell. Sci. - published January 19, 2016
2. Irobalieva RN, Martins B, Medalia O
Protonation-dependent conformational dynamics of the multidrug transporter EmrE.
1. Proc. Natl. Acad. Sci. U.S.A. - published January 19, 2016
2. Dastvan R, Fischer AW, Mishra S, Meiler J, Mchaourab HS
PGL germ granule assembly protein is a base-specific, single-stranded RNase.
1. Proc. Natl. Acad. Sci. U.S.A. - published January 19, 2016
2. Aoki ST, Kershner AM, Bingman CA, Wickens M, Kimble J
A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.
1. J. Exp. Med. - published January 18, 2016
2. Chan AY, Punwani D, Kadlecek TA, Cowan MJ, Olson JL, Mathes EF, Sunderam U, Fu SM, Srinivasan R, Kuriyan J, Brenner SE, Weiss A, Puck JM
Gene-Based Association Analysis for Censored Traits Via Fixed Effect Functional Regressions.
1. Genet. Epidemiol. - published January 18, 2016
2. Fan R, Wang Y, Yan Q, Ding Y, Weeks DE, Lu Z, Ren H, Cook RJ, Xiong M, Swaroop A, Chew EY, Chen W
The structure and catalytic mechanism of Human Sphingomyelin Phosphodiesterase like 3a - an acid sphingomyelinase homolog with a novel nucleotide hydrolase activity.
1. FEBS J. - published January 18, 2016
2. Lim SM, Yeung K, Trésaugues L, Ling TH, Nordlund P
Structural Insights into KCTD Protein Assembly and Cullin3 Recognition.
1. J. Mol. Biol. - published January 16, 2016
2. Ji AX, Chu A, Nielsen TK, Benlekbir S, Rubinstein JL, Privé GG
The macromolecular architecture of platelet-derived microparticles.
1. J. Struct. Biol. - published January 16, 2016
2. Tamir A, Sorrentino S, Motahedeh S, Shai E, Dubrovsky A, Dahan I, Eibauer M, Studt JD, Sapra KT, Varon D, Medalia O
PAK6 targets to cell-cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape.
1. J. Cell. Sci. - published January 15, 2016
2. Morse EM, Sun X, Olberding JR, Ha BH, Boggon TJ, Calderwood DA
Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation.
1. Cell - published January 14, 2016
2. Greber BJ, Gerhardy S, Leitner A, Leibundgut M, Salem M, Boehringer D, Leulliot N, Aebersold R, Panse VG, Ban N
Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.
1. Cell - published January 14, 2016
2. Lee S, Kopp F, Chang TC, Sataluri A, Chen B, Sivakumar S, Yu H, Xie Y, Mendell JT
Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling.
1. Cell - published January 14, 2016
2. Hospenthal MK, Redzej A, Dodson K, Ukleja M, Frenz B, Rodrigues C, Hultgren SJ, DiMaio F, Egelman EH, Waksman G
Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
1. Nat Commun - published January 14, 2016
2. Feracci M, Foot JN, Grellscheid SN, Danilenko M, Stehle R, Gonchar O, Kang HS, Dalgliesh C, Meyer NH, Liu Y, Lahat A, Sattler M, Eperon IC, Elliott DJ, Dominguez C
Molecular and Structural Analysis of the Helicobacter pylori cag Type IV Secretion System Core Complex.
1. MBio - published January 14, 2016
2. Frick-Cheng AE, Pyburn TM, Voss BJ, McDonald WH, Ohi MD, Cover TL
Dimerization and DNA recognition rules of mithramycin and its analogues.
1. J. Inorg. Biochem. - published January 14, 2016
2. Weidenbach S, Hou C, Chen JM, Tsodikov OV, Rohr J
The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase.
1. Elife - published January 14, 2016
2. Richardson BC, Halaby SL, Gustafson MA, Fromme JC
Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome Engineering.
1. Cell - published January 14, 2016
2. Wright AV, Nuñez JK, Doudna JA
Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance.
1. Cell - published January 14, 2016
2. Marcotte R, Sayad A, Brown KR, Sanchez-Garcia F, Reimand J, Haider M, Virtanen C, Bradner JE, Bader GD, Mills GB, Pe'er D, Moffat J, Neel BG
5'-C-Malonyl RNA: Small Interfering RNAs Modified with 5'-Monophosphate Bioisostere Demonstrate Gene Silencing Activity.
1. ACS Chem. Biol. - published January 13, 2016
2. Zlatev I, Foster DJ, Liu J, Charisse K, Brigham B, Parmar RG, Jadhav V, Maier MA, Rajeev KG, Egli M, Manoharan M
Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli.
1. Elife - published January 13, 2016
2. Zimanyi CM, Chen PY, Kang G, Funk MA, Drennan CL
Understanding transport by the major facilitator superfamily (MFS): structures pave the way.
1. Nat. Rev. Mol. Cell Biol. - published January 13, 2016
2. Quistgaard EM, Löw C, Guettou F, Nordlund P
Crystal Structure of the PdAu24(SR)18(0) Superatom.
1. Inorg Chem - published January 13, 2016
2. Tofanelli MA, Ni TW, Phillips BD, Ackerson CJ
Structures of two distinct conformations of holo-non-ribosomal peptide synthetases.
1. Nature - published January 13, 2016
2. Drake EJ, Miller BR, Shi C, Tarrasch JT, Sundlov JA, Allen CL, Skiniotis G, Aldrich CC, Gulick AM
Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6.
1. RNA - published January 13, 2016
2. Niewoehner O, Jinek M
Red cell receptors as access points for malaria infection.
1. Curr. Opin. Hematol. - published January 13, 2016
2. Salinas ND, Tolia NH
Five of five VHHs neutralizing poliovirus bind the receptor-binding site.
1. J. Virol. - published January 13, 2016
2. Strauss M, Schotte L, Thys B, Filman DJ, Hogle JM
A quantitative investigation of linker histone interactions with nucleosomes and chromatin.
1. Sci Rep - published January 12, 2016
2. White AE, Hieb AR, Luger K
Molecular basis for the interaction between Adaptor Protein Complex 4 (AP4) β4 and its accessory protein, tepsin.
1. Traffic - published January 12, 2016
2. Frazier MN, Davies AK, Voehler M, Kendall AK, Borner GH, Chazin WJ, Robinson MS, Jackson LP
Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviors.
1. Br. J. Pharmacol. - published January 12, 2016
2. Liu S, Feng J, Luo J, Yang P, Brett TJ, Hu H
Soluble oligomers of the pore-forming toxin Cytolysin A from Escherichia coli are off-pathway products of pore assembly.
1. J. Biol. Chem. - published January 12, 2016
2. Roderer D, Benke S, Schuler B, Glockshuber R
How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin.
1. J. Biol. Chem. - published January 12, 2016
2. Pozzi N, Chen Z, Di Cera E
The tRNA Elbow in Structure, Recognition and Evolution.
1. Life (Basel) - published January 12, 2016
2. Zhang J, Ferré-D'Amaré AR
Carbenoxolone inhibits Pannexin1 channels through interactions in the first extracellular loop.
1. J. Gen. Physiol. - published January 11, 2016
2. Michalski K, Kawate T
Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers.
1. J. Immunol. - published January 11, 2016
2. Roy S, Ly D, Castro CD, Li NS, Hawk AJ, Altman JD, Meredith SC, Piccirilli JA, Moody DB, Adams EJ
Analysis of TcdBs within the hypervirulent clade 2 reveals an impact of RhoA glucosylation in Clostridium difficile pro inflammatory activities.
1. Infect. Immun. - published January 11, 2016
2. Quesada-Gómez C, López-Ureña D, Chumbler N, Kroh HK, Castro-Peña C, Rodríguez C, Orozco-Aguilar J, González-Camacho S, Rucavado A, Guzmán-Verri C, Lawley TD, Lacy DB, Chaves-Olarte E
Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis.
1. Dev. Cell - published January 11, 2016
2. Huang J, Liu X, Li D, Shao Z, Cao H, Zhang Y, Trompouki E, Bowman TV, Zon LI, Yuan GC, Orkin SH, Xu J
Crystal structure of Clostridium difficile toxin A.
1. Nat Microbiol - published January 11, 2016
2. Chumbler NM, Rutherford SA, Zhang Z, Farrow MA, Lisher JP, Farquhar E, Giedroc DP, Spiller BW, Melnyk RA, Lacy DB
The Combination of X-Ray Crystallography and Cryo-Electron Microscopy Provides Insight into the Overall Architecture of the Dodecameric Rvb1/Rvb2 Complex.
1. PLoS ONE - published January 9, 2016
2. Silva-Martin N, Daudén MI, Glatt S, Hoffmann NA, Kastritis P, Bork P, Beck M, Müller CW
Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction.
1. Sci Rep - published January 8, 2016
2. Vincendeau M, Hadian K, Messias AC, Brenke JK, Halander J, Griesbach R, Greczmiel U, Bertossi A, Stehle R, Nagel D, Demski K, Velvarska H, Niessing D, Geerlof A, Sattler M, Krappmann D
Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha.
1. Elife - published January 8, 2016
2. Weber J, Bao H, Hartlmüller C, Wang Z, Windhager A, Janowski R, Madl T, Jin P, Niessing D
Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication Protein A.
1. ChemMedChem - published January 8, 2016
2. Patrone JD, Pelz NF, Bates BS, Souza-Fagundes EM, Vangamudi B, Camper DV, Kuznetsov AG, Browning CF, Feldkamp MD, Frank AO, Gilston BA, Olejniczak ET, Rossanese OW, Waterson AG, Chazin WJ, Fesik SW
PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway.
1. Mol. Cell - published January 7, 2016
2. Yang Z, Chen KM, Pandey RR, Homolka D, Reuter M, Janeiro BK, Sachidanandam R, Fauvarque MO, McCarthy AA, Pillai RS
Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains.
1. Mol. Cell - published January 7, 2016
2. Thierry E, Guilligay D, Kosinski J, Bock T, Gaudon S, Round A, Pflug A, Hengrung N, El Omari K, Baudin F, Hart DJ, Beck M, Cusack S
Molecular Mechanism Underlying the Plant NRT1.1 Dual-Affinity Nitrate Transporter.
1. Front Physiol - published January 7, 2016
2. Sun J, Zheng N
Conformational Sampling and Binding Site Assessment of Suppression of Tumorigenicity 2 Ectodomain.
1. PLoS ONE - published January 7, 2016
2. Yang CY, Delproposto J, Chinnaswamy K, Brown WC, Wang S, Stuckey JA, Wang X
The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies.
1. Annu. Rev. Pharmacol. Toxicol. - published January 6, 2016
2. Martinez Molina D, Nordlund P
Smartphone Microscopy of Parasite Eggs Accumulated into a Single Field of View.
1. Am. J. Trop. Med. Hyg. - published January 6, 2016
2. Sowerby SJ, Crump JA, Johnstone MC, Krause KL, Hill PC
Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects.
1. Neuron - published January 6, 2016
2. Zhou Y, Kaiser T, Monteiro P, Zhang X, Van der Goes MS, Wang D, Barak B, Zeng M, Li C, Lu C, Wells M, Amaya A, Nguyen S, Lewis M, Sanjana N, Zhou Y, Zhang M, Zhang F, Fu Z, Feng G
Tunable protein synthesis by transcript isoforms in human cells.
1. Elife - published January 6, 2016
2. Floor SN, Doudna JA
Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.
1. Nature - published January 6, 2016
2. Shu S, Lin CY, He HH, Witwicki RM, Tabassum DP, Roberts JM, Janiszewska M, Huh SJ, Liang Y, Ryan J, Doherty E, Mohammed H, Guo H, Stover DG, Ekram MB, Peluffo G, Brown J, D'Santos C, Krop IE, Dillon D, McKeown M, Ott C, Qi J, Ni M, Rao PK, Duarte M, Wu SY, Chiang CM, Anders L, Young RA, Winer EP, Letai A, Barry WT, Carroll JS, Long HW, Brown M, Liu XS, Meyer CA, Bradner JE, Polyak K
Characterization of Antibody Bipolar Bridging Mediated by the Human Cytomegalovirus Fc receptor gp68.
1. J. Virol. - published January 6, 2016
2. Ndjamen B, Joshi DS, Fraser SE, Bjorkman PJ
Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase η.
1. J. Biol. Chem. - published January 6, 2016
2. Su Y, Egli M, Guengerich FP
Parallel Evolution of Chemokine Binding by Structurally Related Herpesvirus Decoy Receptors.
1. Structure - published January 5, 2016
2. Lubman OY, Fremont DH
Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis.
1. Structure - published January 5, 2016
2. East A, Mechaly AE, Huysmans GH, Bernarde C, Tello-Manigne D, Nadeau N, Pugsley AP, Buschiazzo A, Alzari PM, Bond PJ, Francetic O
Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.
1. Cell Rep - published January 5, 2016
2. Bradley T, Fera D, Bhiman J, Eslamizar L, Lu X, Anasti K, Zhang R, Sutherland LL, Scearce RM, Bowman CM, Stolarchuk C, Lloyd KE, Parks R, Eaton A, Foulger A, Nie X, Karim SS, Barnett S, Kelsoe G, Kepler TB, Alam SM, Montefiori DC, Moody MA, Liao HX, Morris L, Santra S, Harrison SC, Haynes BF
Characterization of the Domain Orientations of E. coli 5'-Nucleotidase by Fitting an Ensemble of Conformers to DEER Distance Distributions.
1. Structure - published January 5, 2016
2. Krug U, Alexander NS, Stein RA, Keim A, Mchaourab HS, Sträter N, Meiler J
Structural Basis for the Non-catalytic Functions of Protein Kinases.
1. Structure - published January 5, 2016
2. Kung JE, Jura N
EMDataBank unified data resource for 3DEM.
1. Nucleic Acids Res - published January 4, 2016
2. Lawson CL, Patwardhan A, Baker ML, Hryc C, Garcia ES, Hudson BP, Lagerstedt I, Ludtke SJ, Pintilie G, Sala R, Westbrook JD, Berman HM, Kleywegt GJ, Chiu W
Validation of SCT Methylation as a Hallmark Biomarker for Lung Cancers.
1. J Thorac Oncol - published January 4, 2016
2. Zhang YA, Ma X, Sathe A, Fujimoto J, Wistuba II, Lam S, Yatabe Y, Wang YW, Stastny V, Gao B, Larsen JE, Girard L, Liu X, Song K, Behrens C, Kalhor N, Xie Y, Zhang MQ, Minna JD, Gazdar AF
Nascent peptide assists the ribosome in recognizing chemically distinct small molecules.
1. Nat. Chem. Biol. - published January 4, 2016
2. Gupta P, Liu B, Klepacki D, Gupta V, Schulten K, Mankin AS, Vázquez-Laslop N
UTOPIA NMR: activating unexploited magnetization using interleaved low-gamma detection.
1. J. Biomol. NMR - published January 4, 2016
2. Viegas A, Viennet T, Yu TY, Schumann F, Bermel W, Wagner G, Etzkorn M
Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition.
1. Eur J Med Chem - published January 2, 2016
2. Goyard D, Kónya B, Chajistamatiou AS, Chrysina ED, Leroy J, Balzarin S, Tournier M, Tousch D, Petit P, Duret C, Maurel P, Somsák L, Docsa T, Gergely P, Praly JP, Azay-Milhau J, Vidal S
The INNs and outs of antibody nonproprietary names.
1. MAbs - published January 2, 2016
2. Jones TD, Carter PJ, Plückthun A, Vásquez M, Holgate RG, Hötzel I, Popplewell AG, Parren PW, Enzelberger M, Rademaker HJ, Clark MR, Lowe DC, Dahiyat BI, Smith V, Lambert JM, Wu H, Reilly M, Haurum JS, Dübel S, Huston JS, Schirrmann T, Janssen RA, Steegmaier M, Gross JA, Bradbury AR, Burton DR, Dimitrov DS, Chester KA, Glennie MJ, Davies J, Walker A, Martin S, McCafferty J, Baker MP
In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.
1. Science - published January 2, 2016
2. Nelson CE, Hakim CH, Ousterout DG, Thakore PI, Moreb EA, Castellanos Rivera RM, Madhavan S, Pan X, Ran FA, Yan WX, Asokan A, Zhang F, Duan D, Gersbach CA
In vivo gene editing in dystrophic mouse muscle and muscle stem cells.
1. Science - published January 2, 2016
2. Tabebordbar M, Zhu K, Cheng JKW, Chew WL, Widrick JJ, Yan WX, Maesner C, Wu EY, Xiao R, Ran FA, Cong L, Zhang F, Vandenberghe LH, Church GM, Wagers AJ
Probabilistic validation of protein NMR chemical shift assignments.
1. J. Biomol. NMR - published January 2, 2016
2. Dashti H, Tonelli M, Lee W, Westler WM, Cornilescu G, Ulrich EL, Markley JL
Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation.
1. Nature - published January 2, 2016
2. Lechtenberg BC, Rajput A, Sanishvili R, Dobaczewska MK, Ware CF, Mace PD, Riedl SJ
Mutations in TUBB8 and Human Oocyte Meiotic Arrest.
1. N Engl J Med - published January 2, 2016
2. Feng R, Sang Q, Kuang Y, Sun X, Yan Z, Zhang S, Shi J, Tian G, Luchniak A, Fukuda Y, Li B, Yu M, Chen J, Xu Y, Guo L, Qu R, Wang X, Sun Z, Liu M, Shi H, Wang H, Feng Y, Shao R, Chai R, Li Q, Xing Q, Zhang R, Nogales E, Jin L, He L, Gupta ML Jr, Cowan NJ, Wang L
Mechanism of imidazolium ionic liquids toxicity in Saccharomyces cerevisiae and rational engineering of a tolerant, xylose-fermenting strain.
1. Microb Cell Fact - published January 2, 2016
2. Dickinson Q, Bottoms S, Hinchman L, McIlwain S, Li S, Myers CL, Boone C, Coon JJ, Hebert A, Sato TK, Landick R, Piotrowski JS
Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection.
1. Cell - published January 2, 2016
2. Flyak AI, Shen X, Murin CD, Turner HL, David JA, Fusco ML, Lampley R, Kose N, Ilinykh PA, Kuzmina N, Branchizio A, King H, Brown L, Bryan C, Davidson E, Doranz BJ, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Saphire EO, Ward AB, Bukreyev A, Crowe JE Jr
Translation from the 5' untranslated region shapes the integrated stress response.
1. Science - published January 2, 2016
2. Starck SR, Tsai JC, Chen K, Shodiya M, Wang L, Yahiro K, Martins-Green M, Shastri N, Walter P
Improved large-scale prediction of growth inhibition patterns using the NCI60 cancer cell line panel.
1. Bioinformatics - published January 1, 2016
2. Cortés-Ciriano I, van Westen GJ, Bouvier G, Nilges M, Overington JP, Bender A, Malliavin TE
Dengue Virus prM-Specific Human Monoclonal Antibodies with Virus Replication-Enhancing Properties Recognize a Single Immunodominant Antigenic Site.
1. J Virol - published January 1, 2016
2. Smith SA, Nivarthi UK, de Alwis R, Kose N, Sapparapu G, Bombardi R, Kahle KM, Pfaff JM, Lieberman S, Doranz BJ, de Silva AM, Crowe JE Jr
The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation.
1. Dev Biol - published January 1, 2016
2. Chang H, Smallwood PM, Williams J, Nathans J
Substrate structure-activity relationships guide rational engineering of modular polyketide synthase ketoreductases.
1. Chem Commun (Camb) - published January 1, 2016
2. Bailey CB, Pasman ME, Keatinge-Clay AT
Structural Plasticity of the Protein Plug That Traps Newly Packaged Genomes in Podoviridae Virions.
1. J Biol Chem - published January 1, 2016
2. Bhardwaj A, Sankhala RS, Olia AS, Brooke D, Casjens SR, Taylor DJ, Prevelige PE Jr, Cingolani G
Kinetic and structural studies reveal a unique binding mode of sulfite to the nickel center in urease.
1. J Inorg Biochem - published January 1, 2016
2. Mazzei L, Cianci M, Benini S, Bertini L, Musiani F, Ciurli S
Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.
1. J Biol Chem - published January 1, 2016
2. Pilecki B, Holm AT, Schlosser A, Moeller JB, Wohl AP, Zuk AV, Heumüller SE, Wallis R, Moestrup SK, Sengle G, Holmskov U, Sorensen GL
Rationally engineered Cas9 nucleases with improved specificity.
1. Science - published January 1, 2016
2. Slaymaker IM, Gao L, Zetsche B, Scott DA, Yan WX, Zhang F
Time series modeling of live-cell shape dynamics for image-based phenotypic profiling.
1. Integr Biol (Camb) - published January 1, 2016
2. Gordonov S, Hwang MK, Wells A, Gertler FB, Lauffenburger DA, Bathe M
Applications of CRISPR-Cas systems in neuroscience.
1. Nat Rev Neurosci - published January 1, 2016
2. Heidenreich M, Zhang F
Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity.
1. Nat Struct Mol Biol - published January 1, 2016
2. Wright JD, Mace PD, Day CL
Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex.
1. Nat Struct Mol Biol - published January 1, 2016
2. Heider MR, Gu M, Duffy CM, Mirza AM, Marcotte LL, Walls AC, Farrall N, Hakhverdyan Z, Field MC, Rout MP, Frost A, Munson M
The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma.
1. Oncotarget - published January 1, 2016
2. Dadey DY, Kapoor V, Khudanyan A, Urano F, Kim AH, Thotala D, Hallahan DE
Mapping translation 'hot-spots' in live cells by tracking single molecules of mRNA and ribosomes.
1. Elife - published January 1, 2016
2. Katz ZB, English BP, Lionnet T, Yoon YJ, Monnier N, Ovryn B, Bathe M, Singer RH
P1 Ref Endonuclease: A Molecular Mechanism for Phage-Enhanced Antibiotic Lethality.
1. PLoS Genet - published January 1, 2016
2. Ronayne EA, Wan YC, Boudreau BA, Landick R, Cox MM
In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures.
1. Acta Crystallogr D Struct Biol - published January 1, 2016
2. Huang CY, Olieric V, Ma P, Howe N, Vogeley L, Liu X, Warshamanage R, Weinert T, Panepucci E, Kobilka B, Diederichs K, Wang M, Caffrey M
Bacillus licheniformis trehalose-6-phosphate hydrolase structures suggest keys to substrate specificity.
1. Acta Crystallogr D Struct Biol - published January 1, 2016
2. Lin MG, Chi MC, Naveen V, Li YC, Lin LL, Hsiao CD