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115 Member Publications for November 2015

Computational prediction of protein interfaces: A review of data driven methods.
1. FEBS Lett. - published November 30, 2015
2. Xue LC, Dobbs D, Bonvin AM, Honavar V
The Lysosomal Protein Saposin B Binds Chloroquine.
1. ChemMedChem - published November 30, 2015
2. Huta BP, Mehlenbacher MR, Nie Y, Lai X, Zubieta C, Bou-Abdallah F, Doyle RP
A synthetic lethal approach for compound and target identification in Staphylococcus aureus.
1. Nat. Chem. Biol. - published November 30, 2015
2. Pasquina L, Santa Maria JP, McKay Wood B, Moussa SH, Matano LM, Santiago M, Martin SE, Lee W, Meredith TC, Walker S
Palliative Care and Symptom Management in Older Patients with Cancer.
1. Clin. Geriatr. Med. - published November 29, 2015
2. Alexander K, Goldberg J, Korc-Grodzicki B
Climate sensitivity uncertainty: when is good news bad?
1. Philos Trans A Math Phys Eng Sci - published November 28, 2015
2. Freeman MC, Wagner G, Zeckhauser RJ
Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases.
1. Mediators Inflamm. - published November 28, 2015
2. Sala-Rabanal M, Yurtsever Z, Berry KN, Brett TJ
Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains.
1. Nat Commun - published November 27, 2015
2. Kim H, An S, Ro SH, Teixeira F, Park GJ, Kim C, Cho CS, Kim JS, Jakob U, Lee JH, Cho US
Distinct functional determinants of influenza hemagglutinin-mediated membrane fusion.
1. Elife - published November 27, 2015
2. Ivanovic T, Harrison SC
Foreign DNA capture during CRISPR-Cas adaptive immunity.
1. Nature - published November 26, 2015
2. Nuñez JK, Harrington LB, Kranzusch PJ, Engelman AN, Doudna JA
A Simple Proteomics-Based Approach to Identification of Immunodominant Antigens from a Complex Pathogen: Application to the CD4 T Cell Response against Human Herpesvirus 6B.
1. PLoS ONE - published November 25, 2015
2. Becerra-Artiles A, Dominguez-Amorocho O, Stern LJ, Calvo-Calle JM
Structure of an HIV-2 gp120 in Complex with CD4.
1. J. Virol. - published November 25, 2015
2. Davenport YW, West AP, Bjorkman PJ
Single-particle cryo-electron microscopy of macromolecular complexes.
1. Microscopy (Oxf) - published November 25, 2015
2. Skiniotis G, Southworth DR
What is the Prevalence and Success of Remediation of Emergency Medicine Residents?
1. West J Emerg Med - published November 24, 2015
2. Silverberg M, Weizberg M, Murano T, Smith JL, Burkhardt JC, Santen SA
Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging.
1. Proc. Natl. Acad. Sci. U.S.A. - published November 24, 2015
2. Maute RL, Gordon SR, Mayer AT, McCracken MN, Natarajan A, Ring NG, Kimura R, Tsai JM, Manglik A, Kruse AC, Gambhir SS, Weissman IL, Ring AM
Atomic-resolution structure of the CAP-Gly domain of dynactin on polymeric microtubules determined by magic angle spinning NMR spectroscopy.
1. Proc. Natl. Acad. Sci. U.S.A. - published November 24, 2015
2. Yan S, Guo C, Hou G, Zhang H, Lu X, Williams JC, Polenova T
A Cellular System for Spatial Signal Decoding in Chemical Gradients.
1. Dev. Cell - published November 23, 2015
2. Hegemann B, Unger M, Lee SS, Stoffel-Studer I, van den Heuvel J, Pelet S, Koeppl H, Peter M
ESCRT Filaments as Spiral Springs.
1. Dev. Cell - published November 23, 2015
2. Carlson LA, Shen QT, Pavlin MR, Hurley JH
Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy.
1. Nat Chem - published November 21, 2015
2. Hall JP, Poynton FE, Keane PM, Gurung SP, Brazier JA, Cardin DJ, Winter G, Gunnlaugsson T, Sazanovich IV, Towrie M, Cardin CJ, Kelly JM, Quinn SJ
Characterization of the Pseudomonas aeruginosa Glycoside Hydrolase PslG Reveals That Its Levels Are Critical for Psl Polysaccharide Biosynthesis and Biofilm Formation.
1. J. Biol. Chem. - published November 20, 2015
2. Baker P, Whitfield GB, Hill PJ, Little DJ, Pestrak MJ, Robinson H, Wozniak DJ, Howell PL
Controlling microbial contamination during hydrolysis of AFEX-pretreated corn stover and switchgrass: effects on hydrolysate composition, microbial response and fermentation.
1. Biotechnol Biofuels - published November 20, 2015
2. Serate J, Xie D, Pohlmann E, Donald C Jr, Shabani M, Hinchman L, Higbee A, Mcgee M, La Reau A, Klinger GE, Li S, Myers CL, Boone C, Bates DM, Cavalier D, Eilert D, Oates LG, Sanford G, Sato TK, Dale B, Landick R, Piotrowski J, Ong RG, Zhang Y
Access to Cyclic Amino Boronates via Rhodium-Catalyzed Functionalization of Alkyl MIDA Boronates.
1. Org. Lett. - published November 20, 2015
2. St Denis JD, Lee CF, Yudin AK
Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures.
1. Cell - published November 19, 2015
2. Ru H, Chambers MG, Fu TM, Tong AB, Liao M, Wu H
Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress.
1. Cell - published November 19, 2015
2. Fox JM, Long F, Edeling MA, Lin H, van Duijl-Richter MK, Fong RH, Kahle KM, Smit JM, Jin J, Simmons G, Doranz BJ, Crowe JE, Fremont DH, Rossmann MG, Diamond MS
Cut and paste RNA for nuclear magnetic resonance, paramagnetic resonance enhancement, and electron paramagnetic resonance structural studies.
1. Methods Enzymol - published November 19, 2015
2. Duss O, Diarra Dit Konté N, Allain FH
Selective amino acid segmental labeling of multi-domain proteins.
1. Methods Enzymol - published November 19, 2015
2. Michel E, Allain FH
Effective isotope labeling of proteins in a mammalian expression system.
1. Meth. Enzymol. - published November 19, 2015
2. Sastry M, Bewley CA, Kwong PD
Use of Nanostructure-Initiator Mass Spectrometry to Deduce Selectivity of Reaction in Glycoside Hydrolases.
1. Front Bioeng Biotechnol - published November 19, 2015
2. Deng K, Takasuka TE, Bianchetti CM, Bergeman LF, Adams PD, Northen TR, Fox BG
Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes.
1. Cell - published November 19, 2015
2. Yeap LS, Hwang JK, Du Z, Meyers RM, Meng FL, Jakubauskaitė A, Liu M, Mani V, Neuberg D, Kepler TB, Wang JH, Alt FW
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.
1. Science - published November 19, 2015
2. Saxton RA, Knockenhauer KE, Wolfson RL, Chantranupong L, Pacold ME, Wang T, Schwartz TU, Sabatini DM
Perplexing new insight into the dynamics of the EmrE transporter.
1. J. Gen. Physiol. - published November 18, 2015
2. Sanders CR
An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell.
1. Elife - published November 18, 2015
2. Coffey MJ, Sleebs BE, Uboldi AD, Garnham A, Franco M, Marino ND, Panas MW, Ferguson DJ, Enciso M, O'Neill MT, Lopaticki S, Stewart RJ, Dewson G, Smyth GK, Smith BJ, Masters SL, Boothroyd JC, Boddey JA, Tonkin CJ
Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular Aspergillus fumigatus Hyphal Growth and Corneal Infection.
1. J. Immunol. - published November 18, 2015
2. Clark HL, Jhingran A, Sun Y, Vareechon C, de Jesus Carrion S, Skaar EP, Chazin WJ, Calera JA, Hohl TM, Pearlman E
The Special Issue of Microscopy on single-particle cryo-electron microscopy.
1. Microscopy (Oxf) - published November 18, 2015
2. Cheng Y, Walz T
The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila.
1. PLoS ONE - published November 17, 2015
2. Jacomin AC, Bescond A, Soleilhac E, Gallet B, Schoehn G, Fauvarque MO, Taillebourg E
Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction.
1. Nat Commun - published November 17, 2015
2. Horn A, Hennig J, Ahmed YL, Stier G, Wild K, Sattler M, Sinning I
A composite approach towards a complete model of the myosin rod.
1. Proteins - published November 17, 2015
2. Korkmaz EN, Taylor KC, Andreas MP, Ajay G, Heinze NT, Cui Q, Rayment I
High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction.
1. Proc. Natl. Acad. Sci. U.S.A. - published November 17, 2015
2. Thomaston JL, Alfonso-Prieto M, Woldeyes RA, Fraser JS, Klein ML, Fiorin G, DeGrado WF
The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane.
1. Nat. Cell Biol. - published November 16, 2015
2. Baskin JM, Wu X, Christiano R, Oh MS, Schauder CM, Gazzerro E, Messa M, Baldassari S, Assereto S, Biancheri R, Zara F, Minetti C, Raimondi A, Simons M, Walther TC, Reinisch KM, De Camilli P
Dynamics of CRISPR-Cas9 genome interrogation in living cells.
1. Science - published November 13, 2015
2. Knight SC, Xie L, Deng W, Guglielmi B, Witkowsky LB, Bosanac L, Zhang ET, El Beheiry M, Masson JB, Dahan M, Liu Z, Doudna JA, Tjian R
CH3-specific NMR assignment of alanine, isoleucine, leucine and valine methyl groups in high molecular weight proteins using a single sample.
1. J. Biomol. NMR - published November 13, 2015
2. Kerfah R, Hamelin O, Boisbouvier J, Marion D
An active site rearrangement within the Tetrahymena group I ribozyme releases nonproductive interactions and allows formation of catalytic interactions.
1. RNA - published November 13, 2015
2. Sengupta RN, Van Schie SN, Giambaşu G, Dai Q, Yesselman JD, York D, Piccirilli JA, Herschlag D
The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
1. Nature - published November 12, 2015
2. Mullins EA, Shi R, Parsons ZD, Yuen PK, David SS, Igarashi Y, Eichman BF
Molecular biology: DNA repair without flipping out.
1. Nature - published November 12, 2015
2. Shin DS, Tainer JA
Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency.
1. Sci Signal - published November 12, 2015
2. Moraga I, Richter D, Wilmes S, Winkelmann H, Jude K, Thomas C, Suhoski MM, Engleman EG, Piehler J, Garcia KC
Synthetic Antibodies Inhibit Bcl-2-associated X Protein (BAX) through Blockade of the N-terminal Activation Site.
1. J. Biol. Chem. - published November 12, 2015
2. Uchime O, Dai Z, Biris N, Lee D, Sidhu SS, Li S, Lai JR, Gavathiotis E
Generalized single-particle cryo-EM - a historical perspective.
1. Microscopy (Oxf) - published November 12, 2015
2. Frank J
Superinfection exclusion is absent during acute Junin virus infection of Vero and A549 cells.
1. Sci Rep - published November 10, 2015
2. Gaudin R, Kirchhausen T
Misfolding Ectodomain Mutations of the Lutropin Receptor Increase Efficacy of Hormone Stimulation.
1. Mol. Endocrinol. - published November 10, 2015
2. Charmandari E, Guan R, Zhang M, Silveira LG, Fan QR, Chrousos GP, Sertedaki AC, Latronico AC, Segaloff DL
The ALK/ROS1 inhibitor PF-06463922 overcomes primary resistance to crizotinib in ALK-driven neuroblastoma.
1. Cancer Discov - published November 10, 2015
2. Infarinato NR, Park JH, Krytska K, Ryles HT, Sano R, Szigety KM, Li Y, Zou HY, Lee NV, Smeal T, Lemmon MA, Mosse YP
A Structural Study of CESA1 catalytic domain of Arabidopsis thaliana Cellulose Synthesis Complex: Evidence for CESA trimers.
1. Plant Physiol. - published November 10, 2015
2. Vandavasi VG, Putnam DK, Zhang Q, Petridis L, Heller WT, Nixon BT, Haigler CH, Kalluri U, Coates L, Langan P, Smith JC, Meiler J, O'Neill H
Weighted Distance Functions Improve Analysis of High-Dimensional Data: Application to Molecular Dynamics Simulations.
1. J Chem Theory Comput - published November 10, 2015
2. Blöchliger N, Caflisch A, Vitalis A
Par-4 secretion: stoichiometry of 3-arylquinoline binding to vimentin.
1. Org. Biomol. Chem. - published November 9, 2015
2. Sviripa VM, Burikhanov R, Obiero JM, Yuan Y, Nickell JR, Dwoskin LP, Zhan CG, Liu C, Tsodikov OV, Rangnekar VM, Watt DS
A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.
1. Nat. Med. - published November 9, 2015
2. Menachery VD, Yount BL, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS
Condensation-Driven Assembly of Boron-Containing Bis(Heteroaryl) Motifs Using a Linchpin Approach.
1. Org. Lett. - published November 9, 2015
2. Adachi S, Liew SK, Lee CF, Lough A, He Z, St Denis JD, Poda G, Yudin AK
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2.
1. Nat. Med. - published November 9, 2015
2. Kim KH, Kim W, Howard TP, Vazquez F, Tsherniak A, Wu JN, Wang W, Haswell JR, Walensky LD, Hahn WC, Orkin SH, Roberts CW
EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.
1. Nat. Struct. Mol. Biol. - published November 9, 2015
2. Begley MJ, Yun CH, Gewinner CA, Asara JM, Johnson JL, Coyle AJ, Eck MJ, Apostolou I, Cantley LC
Insights into the Molecular Mechanism of Polymerization and NRTI Incorporation for Human PrimPol.
1. Antimicrob. Agents Chemother. - published November 9, 2015
2. Mislak AC, Anderson KS
Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck.
1. Proc. Natl. Acad. Sci. U.S.A. - published November 9, 2015
2. Banjade S, Wu Q, Mittal A, Peeples WB, Pappu RV, Rosen MK
Mutations in the linker domain affect phospho-STAT3 function and suggest targets for interrupting STAT3 activity.
1. Proc. Natl. Acad. Sci. U.S.A. - published November 9, 2015
2. Mertens C, Haripal B, Klinge S, Darnell JE
Global shape mimicry of tRNA within a viral internal ribosome entry site mediates translational reading frame selection.
1. Proc. Natl. Acad. Sci. U.S.A. - published November 9, 2015
2. Au HH, Cornilescu G, Mouzakis KD, Ren Q, Burke JE, Lee S, Butcher SE, Jan E
Structural Basis for Substrate Specificity in Adenosylcobalamin-dependent Isobutyryl-CoA Mutase and Related Acyl-CoA Mutases.
1. J. Biol. Chem. - published November 6, 2015
2. Jost M, Born DA, Cracan V, Banerjee R, Drennan CL
Chromatin-remodeling and the initiation of transcription.
1. Q. Rev. Biophys. - published November 6, 2015
2. Lorch Y, Kornberg RD
Single-cell analysis of circadian dynamics in tissue explants.
1. Mol Biol Cell - published November 5, 2015
2. Lande-Diner L, Stewart-Ornstein J, Weitz CJ, Lahav G
Orchestration of ErbB3 signaling through heterointeractions and homointeractions.
1. Mol. Biol. Cell - published November 5, 2015
2. McCabe Pryor M, Steinkamp MP, Halasz AM, Chen Y, Yang S, Smith MS, Zahoransky-Kohalmi G, Swift M, Xu XP, Hanein D, Volkmann N, Lidke DS, Edwards JS, Wilson BS
HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation.
1. Cell Stem Cell - published November 5, 2015
2. Qi J, Singh S, Hua WK, Cai Q, Chao SW, Li L, Liu H, Ho Y, McDonald T, Lin A, Marcucci G, Bhatia R, Huang WJ, Chang CI, Kuo YH
Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892.
1. Biochemistry - published November 5, 2015
2. Rudolf JD, Bigelow L, Chang C, Cuff ME, Lohman JR, Chang CY, Ma M, Yang D, Clancy S, Babnigg G, Joachimiak A, Phillips GN, Shen B
Conformational control of DNA target cleavage by CRISPR-Cas9.
1. Nature - published November 5, 2015
2. Sternberg SH, LaFrance B, Kaplan M, Doudna JA
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System.
1. Cell - published November 5, 2015
2. Redding S, Sternberg SH, Marshall M, Gibb B, Bhat P, Guegler CK, Wiedenheft B, Doudna JA, Greene EC
Stable Chromosome Condensation Revealed by Chromosome Conformation Capture.
1. Cell - published November 5, 2015
2. Eagen KP, Hartl TA, Kornberg RD
Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes.
1. Mol. Cell - published November 5, 2015
2. Ma E, Harrington LB, O'Connell MR, Zhou K, Doudna JA
Allergic Lung Inflammation Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysms in Mice.
1. Arterioscler. Thromb. Vasc. Biol. - published November 5, 2015
2. Liu CL, Wang Y, Liao M, Wemmelund H, Ren J, Fernandes C, Zhou Y, Sukhova GK, Lindholt JS, Johnsen SP, Zhang JY, Cheng X, Huang X, Daugherty A, Levy BD, Libby P, Shi GP
Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems.
1. Mol Cell - published November 5, 2015
2. Shmakov S, Abudayyeh OO, Makarova KS, Wolf YI, Gootenberg JS, Semenova E, Minakhin L, Joung J, Konermann S, Severinov K, Zhang F, Koonin EV
Fungal association and utilization of phosphate by plants: success, limitations, and future prospects.
1. Front Microbiol - published November 4, 2015
2. Johri AK, Oelmüller R, Dua M, Yadav V, Kumar M, Tuteja N, Varma A, Bonfante P, Persson BL, Stroud RM
MeshAndCollect: an automated multi-crystal data-collection workflow for synchrotron macromolecular crystallography beamlines.
1. Acta Crystallogr. D Biol. Crystallogr. - published November 4, 2015
2. Zander U, Bourenkov G, Popov AN, de Sanctis D, Svensson O, McCarthy AA, Round E, Gordeliy V, Mueller-Dieckmann C, Leonard GA
Structural and Computational Biology in the Design of Immunogenic Vaccine Antigens.
1. J Immunol Res - published November 4, 2015
2. Liljeroos L, Malito E, Ferlenghi I, Bottomley MJ
Neutron and high-resolution room-temperature X-ray data collection from crystallized lytic polysaccharide monooxygenase.
1. Acta Crystallogr F Struct Biol Commun - published November 4, 2015
2. Bacik JP, Mekasha S, Forsberg Z, Kovalevsky A, Nix JC, Cuneo MJ, Coates L, Vaaje-Kolstad G, Chen JC, Eijsink VG, Unkefer CJ
Development of a High Throughput Platform for Screening Glycoside Hydrolases Based on Oxime-NIMS.
1. Front Bioeng Biotechnol - published November 4, 2015
2. Deng K, Guenther JM, Gao J, Bowen BP, Tran H, Reyes-Ortiz V, Cheng X, Sathitsuksanoh N, Heins R, Takasuka TE, Bergeman LF, Geertz-Hansen H, Deutsch S, Loqué D, Sale KL, Simmons BA, Adams PD, Singh AK, Fox BG, Northen TR
Molecular Mechanism of CCAAT-Enhancer Binding Protein Recruitment by the TRIB1 Pseudokinase.
1. Structure - published November 3, 2015
2. Murphy JM, Nakatani Y, Jamieson SA, Dai W, Lucet IS, Mace PD
Glycine activated ion channel subunits encoded by ctenophore glutamate receptor genes.
1. Proc. Natl. Acad. Sci. U.S.A. - published November 3, 2015
2. Alberstein R, Grey R, Zimmet A, Simmons DK, Mayer ML
Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity.
1. Structure - published November 3, 2015
2. Nicoludis JM, Lau SY, Schärfe CP, Marks DS, Weihofen WA, Gaudet R
N-Methylation as a Strategy for Enhancing the Affinity and Selectivity of RNA-binding Peptides: Application to the HIV-1 Frameshift-Stimulating RNA.
1. ACS Chem. Biol. - published November 3, 2015
2. Hilimire TA, Bennett RP, Stewart RA, Garcia-Miranda P, Blume A, Becker J, Sherer N, Helms ED, Butcher SE, Smith HC, Miller BL
Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus.
1. PLoS One - published November 3, 2015
2. de la Peña AH, Suarez A, Duong-Ly KC, Schoeffield AJ, Pizarro-Dupuy MA, Zarr M, Pineiro SA, Amzel LM, Gabelli SB
PROTEIN ARGININE METHYLTRANSFERASE 8: tetrameric structure and protein substrate specificity.
1. Biochemistry - published November 3, 2015
2. Lee WC, Lin WL, Matsui T, Chen ES, Wei TY, Lin WH, Hu H, Zheng YG, Tsai MD, Ho MC
A PH Domain with Dual Phospholipid Binding Sites Regulates the ARF GAP, ASAP1.
1. Structure - published November 3, 2015
2. Kahn RA, Lambright DG
Molecular dissection of a putative iron reductase from Desulfotomaculum reducens MI-1.
1. Biochem Biophys Res Commun - published November 2, 2015
2. Li Z, Kim DD, Nelson OD, Otwell AE, Richardson RE, Callister SJ, Lin H
Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.
1. Nat. Immunol. - published November 2, 2015
2. Adams JJ, Narayanan S, Birnbaum ME, Sidhu SS, Blevins SJ, Gee MH, Sibener LV, Baker BM, Kranz DM, Garcia KC
ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation.
1. Elife - published November 2, 2015
2. Nady N, Gupta A, Ma Z, Swigut T, Koide A, Koide S, Wysocka J
Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase.
1. Nat. Struct. Mol. Biol. - published November 2, 2015
2. Cappadocia L, Pichler A, Lima CD
MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis.
1. Brain - published November 2, 2015
2. MacNair L, Xiao S, Miletic D, Ghani M, Julien JP, Keith J, Zinman L, Rogaeva E, Robertson J
The interactome challenge.
1. J Cell Biol - published November 2, 2015
2. Aitchison JD, Rout MP
The molecular basis of lysine 48 ubiquitin chain synthesis by Ube2K.
1. Sci Rep - published November 2, 2015
2. Middleton AJ, Day CL
Evolutionary Selection on Barrier Activity: Bar1 Is an Aspartyl Protease with Novel Substrate Specificity.
1. mBio - published November 2, 2015
2. Jones SK Jr, Clarke SC, Craik CS, Bennett RJ
Protein structure prediction guided by crosslinking restraints--A systematic evaluation of the impact of the crosslinking spacer length.
1. Methods - published November 1, 2015
2. Hofmann T, Fischer AW, Meiler J, Kalkhof S
The non-detergent sulfobetaine-201 acts as a pharmacological chaperone to promote folding and crystallization of the type II TGF-β receptor extracellular domain.
1. Protein Expr Purif - published November 1, 2015
2. Wangkanont K, Forest KT, Kiessling LL
The Caltech Tomography Database and Automatic Processing Pipeline.
1. J Struct Biol - published November 1, 2015
2. Ding HJ, Oikonomou CM, Jensen GJ
Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin.
1. Mol Psychiatry - published November 1, 2015
2. Tan Z, Dai W, van Erp TG, Overman J, Demuro A, Digman MA, Hatami A, Albay R, Sontag EM, Potkin KT, Ling S, Macciardi F, Bunney WE, Long JD, Paulsen JS, Ringman JM, Parker I, Glabe C, Thompson LM, Chiu W, Potkin SG
Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase.
1. Bioorg. Med. Chem. Lett. - published November 1, 2015
2. Lee WG, Frey KM, Gallardo-Macias R, Spasov KA, Chan AH, Anderson KS, Jorgensen WL
Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification.
1. Nucleic Acids Res - published November 1, 2015
2. Mbogning J, Pagé V, Burston J, Schwenger E, Fisher RP, Schwer B, Shuman S, Tanny JC
Knockout of cGAS and STING Rescues Virus Infection of Plasmid DNA-Transfected Cells.
1. J Virol - published November 1, 2015
2. Langereis MA, Rabouw HH, Holwerda M, Visser LJ, van Kuppeveld FJ
Asynchronous data acquisition and on-the-fly analysis of dose fractionated cryoEM images by UCSFImage.
1. J Struct Biol - published November 1, 2015
2. Li X, Zheng S, Agard DA, Cheng Y
Structural Insights into the Assembly of the Adeno-associated Virus Type 2 Rep68 Protein on the Integration Site AAVS1.
1. J Biol Chem - published November 1, 2015
2. Musayev FN, Zarate-Perez F, Bishop C, Burgner JW 2nd, Escalante CR
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.
1. Nature - published November 1, 2015
2. Canver MC, Smith EC, Sher F, Pinello L, Sanjana NE, Shalem O, Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S, Kurita R, Nakamura Y, Fujiwara Y, Maeda T, Yuan GC, Zhang F, Orkin SH, Bauer DE
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
1. Nat Genet - published November 1, 2015
2. Kato N, Loh M, Takeuchi F, Verweij N, Wang X, Zhang W, Kelly TN, Saleheen D, Lehne B, Leach IM, Drong AW, Abbott J, Wahl S, Tan ST, Scott WR, Campanella G, Chadeau-Hyam M, Afzal U, Ahluwalia TS, Bonder MJ, Chen P, Dehghan A, Edwards TL, Esko T, Go MJ, Harris SE, Hartiala J, Kasela S, Kasturiratne A, Khor CC, Kleber ME, Li H, Yu Mok Z, Nakatochi M, Sapari NS, Saxena R, Stewart AFR, Stolk L, Tabara Y, Teh AL, Wu Y, Wu JY, Zhang Y, Aits I, Da Silva Couto Alves A, Das S, Dorajoo R, Hopewell JC, Kim YK, Koivula RW, Luan J, Lyytikäinen LP, Nguyen QN, Pereira MA, Postmus I, Raitakari OT, Scannell Bryan M, Scott RA, Sorice R, Tragante V, Traglia M, White J, Yamamoto K, Zhang Y, Adair LS, Ahmed A, Akiyama K, Asif R, Aung T, Barroso I, Bjonnes A, Braun TR, Cai H, Chang LC, Chen CH, Cheng CY, Chong YS, Collins R, Courtney R, Davies G, Delgado G, Do LD, Doevendans PA, Gansevoort RT, Gao YT, Grammer TB, Grarup N, Grewal J, Gu D, Wander GS, Hartikainen AL, Hazen SL, He J, Heng CK, Hixson JE, Hofman A, Hsu C, Huang W, Husemoen LLN, Hwang JY, Ichihara S, Igase M, Isono M, Justesen JM, Katsuya T, Kibriya MG, Kim YJ, Kishimoto M, Koh WP, Kohara K, Kumari M, Kwek K, Lee NR, Lee J, Liao J, Lieb W, Liewald DCM, Matsubara T, Matsushita Y, Meitinger T, Mihailov E, Milani L, Mills R, Mononen N, Müller-Nurasyid M, Nabika T, Nakashima E, Ng HK, Nikus K, Nutile T, Ohkubo T, Ohnaka K, Parish S, Paternoster L, Peng H, Peters A, Pham ST, Pinidiyapathirage MJ, Rahman M, Rakugi H, Rolandsson O, Ann Rozario M, Ruggiero D, Sala CF, Sarju R, Shimokawa K, Snieder H, Sparsø T, Spiering W, Starr JM, Stott DJ, Stram DO, Sugiyama T, Szymczak S, Tang WHW, Tong L, Trompet S, Turjanmaa V, Ueshima H, Uitterlinden AG, Umemura S, Vaarasmaki M, van Dam RM, van Gilst WH, van Veldhuisen DJ, Viikari JS, Waldenberger M, Wang Y, Wang A, Wilson R, Wong TY, Xiang YB, Yamaguchi S, Ye X, Young RD, Young TL, Yuan JM, Zhou X, Asselbergs FW, Ciullo M, Clarke R, Deloukas P, Franke A, Franks PW, Franks S, Friedlander Y, Gross MD, Guo Z, Hansen T, Jarvelin MR, Jørgensen T, Jukema JW, Kähönen M, Kajio H, Kivimaki M, Lee JY, Lehtimäki T, Linneberg A, Miki T, Pedersen O, Samani NJ, Sørensen TIA, Takayanagi R, Toniolo D, BIOS-consortium., CARDIo GRAMplusCD., LifeLines Cohort Study., InterAct Consortium., Ahsan H, Allayee H, Chen YT, Danesh J, Deary IJ, Franco OH, Franke L, Heijman BT, Holbrook JD, Isaacs A, Kim BJ, Lin X, Liu J, März W, Metspalu A, Mohlke KL, Sanghera DK, Shu XO, van Meurs JBJ, Vithana E, Wickremasinghe AR, Wijmenga C, Wolffenbuttel BHW, Yokota M, Zheng W, Zhu D, Vineis P, Kyrtopoulos SA, Kleinjans JCS, McCarthy MI, Soong R, Gieger C, Scott J, Teo YY, He J, Elliott P, Tai ES, van der Harst P, Kooner JS, Chambers JC
Structural Studies of IRF4 Reveal a Flexible Autoinhibitory Region and a Compact Linker Domain.
1. J Biol Chem - published November 1, 2015
2. Remesh SG, Santosh V, Escalante CR
A new protocol to accurately determine microtubule lattice seam location.
1. J Struct Biol - published November 1, 2015
2. Zhang R, Nogales E
Protein domain mapping by internal labeling and single particle electron microscopy.
1. J Struct Biol - published November 1, 2015
2. Ciferri C, Lander GC, Nogales E
Coenzyme A-free activity, crystal structure, and rational engineering of a promiscuous β-ketoacyl thiolase from Ralstonia eutropha.
1. J Mol Catal B Enzym - published November 1, 2015
2. Fage CD, Meinke JL, Keatinge-Clay AT
Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity.
1. Proc Natl Acad Sci U S A - published November 1, 2015
2. Long F, Fong RH, Austin SK, Chen Z, Klose T, Fokine A, Liu Y, Porta J, Sapparapu G, Akahata W, Doranz BJ, Crowe JE Jr, Diamond MS, Rossmann MG
Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers.
1. Genes Dev - published November 1, 2015
2. Stern JL, Theodorescu D, Vogelstein B, Papadopoulos N, Cech TR
Characterization of Septin Ultrastructure in Budding Yeast Using Electron Tomography.
1. Methods Mol Biol - published November 1, 2015
2. Bertin A, Nogales E
Analysis of Three-Dimensional Structures of Exocyst Components.
1. Methods Mol. Biol. - published November 1, 2015
2. Lesigang J, Dong G
A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.
1. Genome Biol - published November 1, 2015
2. Xi L, Schmidt JC, Zaug AJ, Ascarrunz DR, Cech TR
Structure and dynamics of polymyxin-resistance-associated response regulator PmrA in complex with promoter DNA.
1. Nat Commun - published November 1, 2015
2. Lou YC, Weng TH, Li YC, Kao YF, Lin WF, Peng HL, Chou SH, Hsiao CD, Chen C
Sialic acid-dependent cell entry of human enterovirus D68.
1. Nat Commun - published November 1, 2015
2. Liu Y, Sheng J, Baggen J, Meng G, Xiao C, Thibaut HJ, van Kuppeveld FJ, Rossmann MG
Protein-RNA interaction restricts telomerase from running through the stop sign.
1. Nat Struct Mol Biol - published November 1, 2015
2. Xi L, Cech TR