Supported Applications


  • Description

    a pipeline for particle detection in cryo-electron microscopy images using convolutional neural networks trained from positive and unlabeled examples.  Topaz includes methods for micrograph denoising using deep denoising models.

  • Installation

    Use the following command to install this title with the CLI client: $ sbgrid-cli install topaz Copy to clipboard
  • Primary Citation*

    T. Bepler, A. Morin, M. Rapp, J. Brasch, L. Shapiro, and A. J. N. &. B. Berger. 2019. Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs. Nature Methods. 16: 1153-1160.

    • *Full citation information available through

  • Webinars

    Topic: Topaz: particle picking with positive-unlabeled learning
    Speaker: Tristan Bepler, MIT

    Host: Jason Key
    Recorded on Feb 26, 2019

  • Keywords

    Electron Microscopy

  • Default Versions

    Linux 64:  0.2.5

  • Other Versions

      Linux 64:

      0.2.4, 0.2.3
  • Developers

    Tristan Bepler, Alex J. Noble