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SHARP/autoSHARP

  • Description

    an automated structure solution pipeline built around the heavy-atom refinement and phasing program SHARP, the substructure determination program SHELXD, the density modification program SOLOMON and the model building programs BUCCANEER and ARP/wARP. It allows fully automated structure solution by experimental phasing, from merged reflection data to an initial model, without any user intervention.

  • Usage

    To list all executables provided by SHARP/autoSHARP, run: $ sbgrid-list sharpautosharp Copy to clipboard

  • Usage Notes

    autoSHARP is available from the command-line or through the CCP4i interface. This software in included for all academic labs automatically, but users must request a license at https://www.globalphasing.com/sharp/ then copy the license file to /programs/local/autosharp/autosharp_licence. The '/programs/local/autosharp' directory can be created if it does not exist. Note the UK spelling for 'licence'. Once the license file is in place the software will start working.

  • Installation

    Use the following command to install this title with the CLI client: $ sbgrid-cli install sharpautosharp Copy to clipboard Available operating systems: Linux 64, OS X INTEL

  • Primary Citation*

    G. Bricogne, C. Vonrhein, C. Flensburg, M. Schiltz, and W. Paciorek. 2003. Generation, representation and flow of phase information in structure determination: recent developments in and around SHARP 2.0. Acta Crystallogr D Biol Crystallogr. 59(11): 2023-2030.
    (Note: Use this citation for SHARP.)

    C. Vonrhein, E. Blanc, P. Roversi, and G. Bricogne. 2007. Automated structure solution with autoSHARP. Methods Mol Biol. 364: 215-230.
    (Note: Use this citation for autoSHARP.)


    • *Full citation information available through

  • Webinars

    SHARP/autoSHARP

    Topic: Experimental phasing and structure solution with SHARP/autoSHARP
    Presenter: Clemens Vonrhein Software Developer at Global Phasing Ltd.

    Host: Piotr Sliz
    Recorded Date June 19, 2012

  • Keywords

    Crystallography

  • Default Versions

    Linux 64:  20200918 (66.8 MB)
    OS X INTEL:  20200918 (60.9 MB)

  • Other Versions

      Linux 64:

      20200206 (66.7 MB)

    • OS X INTEL:

      20200206 (60.9 MB)

  • Developers

    Clemens Vonrhein, Claus Flensberg, Eric Blanc, Gerard Bricogne, Marc Schiltz, Pietro Roversi, Wlodek Paciorek

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