Supported Applications


  • Description

    an open source method for structure generation, with or without conditional information (a motif, target etc). It can perform a whole range of protein design challenges.

  • Installation

    Use the following command to install this title with the CLI client: $ sbgrid-cli install rfdiffusion Copy to clipboard Available operating systems: Linux 64
  • Primary Citation*

    J. L. Watson, D. Juergens, N. R. Bennett, B. L. Trippe, J. Yim, H. E. Eisenach, W. Ahern, A. J. Borst, R. J. Ragotte, L. F. Milles, B. I. M. Wicky, N. Hanikel, S. J. Pellock, A. Courbet, W. Sheffler, J. Wang, P. Venkatesh, Sappington I, S. V. Torres, A. Lauko, D. Bortoli V, E. Mathieu, S. Ovchinnikov, R. Barzilay, T. S. Jaakkola, F. DiMaio, M. Baek, and D. Baker. 2023. De novo design of protein structure and function with RFdiffusion. Nature.

    • *Full citation information available through

  • Default Versions

    Linux 64:  1.1.0 (9.1 GB)

  • Developers

    David Baker, Joe Watson, Brian Trippe