Supported Applications


  • Description

    a multi-GPU program that corrects beam-induced sample motion on dose fractionated movie stacks. It implements a robust iterative alignment algorithm that delivers precise measurement and correction of both global and non-uniform local motions at single pixel level across the whole frame, suitable for both single-particle and tomographic images.

    MotionCor2 runs on a Linux platform equipped with one or more advanced NVIDIA GPU cards. It has been tested on Tesla k10, k40, k80, GeForce 980, and Titan cards. The current version was compiled against CUDA driver 7.5. CUFFT library is required. Developers also recommend 256 GB or more CPU memory, although 128 GB CPU memory is also workable.

  • Primary Citation*

    S. Zheng, E. Palovcak, J.-P. Armache, Y. Cheng, and D. Agard. 2016. Anisotropic Correction of Beam-induced Motion for Improved Single-particle Electron Cryo-microscopy. Nature Methods.
    (Note: BioArxiv preprint)

    • *Full citation information available through

  • Categories

    Electron Microscopy

  • Default Versions

    Linux 64 20170130

  • Other Available Versions

    Linux 64 20160316
    Linux 64 20160822
    Linux 64 20161019

  • Developers

    David Agard, Yifan Cheng, Shawn Zheng.