(Mixture of Isoforms model) for isoform quantitation using RNA-Seqis a probabilistic framework that quantitates the expression level of alternatively spliced genes from RNA-Seq data, and identifies differentially regulated isoforms or exons across samples.
MISO is installed as a standalone program and as a module within python.
Y. Katz, E. T. Wang, E. M. Airoldi, and C. B. Burge. 2010. Analysis and design of RNA sequencing experiments for identifying isoform regulation. Nature Methods. 7: 1009-1015.
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