Bluesky

SBGridTV

Button for mobile navigation

Supported Applications

DomainSeeker

  • Description

    DomainSeeker is a tool designed for de novo identification of protein domains in cryo-ET maps of protein complexes. DomainSeeker integrates AlphaFold2-predicted models to partition proteins into domains using predicted aligned errors and a clique-based graph cluttering algorithm, and subsequently fits these domains into segmented density maps. Finally, it uses a two-dimensional scoring metric to identify the most probable domain of each density map.

  • Usage

    To list all executables provided by DomainSeeker, run: $ sbgrid-list domainseeker Copy to clipboard
  • Installation

    Use the following command to install this title with the CLI client: $ sbgrid-cli install domainseeker Copy to clipboard Available operating systems: Linux 64, OS X INTEL
  • Citation Note

    Please cite the preprint:


    Lu, Y., Chen, G., Sun, F., Zhu, Y., & Zhang, Z. (2024). De novo identification of protein domains in cryo-electron tomography maps from AlphaFold2 models. bioRxiv, 2024.2011.2021.623534. https://doi.org/10.1101/2024.11.21.623534 

Scroll