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  • Description

    a neural network based algorithm for heterogeneous cryo-EM reconstruction. In particular, the method models a continuous distribution over 3D structures by using a neural network based representation for the volume.

  • Usage

    To list all executables provided by cryoDRGN, run: $ sbgrid-list cryodrgn Copy to clipboard
  • Installation

    Use the following command to install this title with the CLI client: $ sbgrid-cli install cryodrgn Copy to clipboard Available operating systems: Linux 64
  • Primary Citation*

    E. D. Zhong, T. Bepler, B. Berger, and J. H. Davis. 2021. CryoDRGN: reconstruction of heterogeneous cryo-EM structures using neural networks. Nature methods. 18(2): 176-185.

    • *Full citation information available through

  • Citation Note

    Uncovering structural ensembles from single particle cryo-EM data using cryoDRGN.

    Laurel Kinman, Barrett Powell, Ellen Zhong*, Bonnie Berger*, Joey Davis*

    Nature Protocols 2023.

    CryoDRGN: Reconstruction of heterogeneous cryo-EM structures using neural networks.

    Ellen D. Zhong, Tristan Bepler, Bonnie Berger*, Joseph H Davis*

    Nature Methods 2021.

    Reconstructing continuous distributions of 3D protein structure from cryo-EM images.

    Ellen D. Zhong, Tristan Bepler, Joseph H. Davis*, Bonnie Berger*

    ICLR 2020.

  • Webinars


    Topic: CryoDRGN: Deep generative models for reconstructing heterogeneous protein structures from cryo-EM
    Speaker: Ellen Zhong, MIT, Laboratories of Bonnie Berger and Joey Davis

    Host: Shaun Rawson
    Recorded on: May 15, 2020

  • Keywords

    Electron Microscopy

  • Default Versions

    Linux 64:  1.1.2 (6.7 GB)

  • Other Versions

      Linux 64:

      0.3.4 (4.8 GB) , 0.3.4_cu11 (7.7 GB) , 1.1.0 (7.7 GB) , 2.2.0 (7.6 GB) , 2.3.0 (5.4 GB) , 3.0.1-beta (6.0 GB) , 3.1.0-beta (5.8 GB) , 3.2.0-beta (6.0 GB)
  • Developers

    Ellen Zhong, Bonnie Berger