Recent Publications from SBGrid member labs
SBGrid member labs published 133 scientific papers in the last 120 days:
Distinct BimBH3 (BimSAHB) Stapled Peptides for Structural and Cellular Studies.
GH Bird, E Gavathiotis, JL Labelle, SG Katz, LD Walensky
ACS Chem Biol - published March 21, 2014
Understanding Molecular Recognition of Promiscuity of Thermophilic Methionine Adenosyltransferase, sMAT from Sulfolobus solfataricus.
F Wang, S Singh, J Zhang, TD Huber, KE Helmich, M Sunkara, KA Hurley, RD Goff, CA Bingman, AJ Morris, JS Thorson, Jr Phillips GN
FEBS J - published March 20, 2014
Jaagsiekte sheep retrovirus detected in human lung cancer tissue arrays.
NM Linnerth-Petrik, SR Walsh, PN Bogner, C Morrison, SK Wootton
BMC Res Notes - published March 19, 2014
Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport.
DJ Sherman, MB Lazarus, L Murphy, C Liu, S Walker, N Ruiz, D Kahne
Proc Natl Acad Sci U S A - published March 17, 2014
Microarray Discovery of New OGT Substrates: The Medulloblastoma Oncogene OTX2 Is O-GlcNAcylated.
RF Ortiz-Meoz, Y Merbl, MW Kirschner, S Walker
J Am Chem Soc - published March 17, 2014
Discovery of dual ZAP70 and Syk kinases inhibitors by docking into a rare C-helix-out conformation of Syk.
H Zhao, A Caflisch
Bioorg Med Chem Lett - published March 15, 2014
Scm3 deposits a (Cse4-H4)2 tetramer onto DNA through a Cse4-H4 dimer intermediate.
ML Dechassa, K Wyns, K Luger
Nucleic Acids Res - published March 12, 2014
Assignments of RNase A by ADAPT-NMR and enhancer.
M Tonelli, CH Eller, KK Singarapu, W Lee, A Bahrami, WM Westler, RT Raines, JL Markley
Biomol NMR Assign - published March 12, 2014
2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.
SY Wu, X Yang, KM Gharpure, H Hatakeyama, M Egli, MH McGuire, AS Nagaraja, TM Miyake, R Rupaimoole, CV Pecot, M Taylor, S Pradeep, M Sierant, C Rodriguez-Aguayo, HJ Choi, RA Previs, GN Armaiz-Pena, L Huang, C Martinez, T Hassell, C Ivan, V Sehgal, R Singhania, HD Han, C Su, JH Kim, HJ Dalton, C Kovvali, K Keyomarsi, NA McMillan, WW Overwijk, J Liu, JS Lee, KA Baggerly, G Lopez-Berestein, PT Ram, B Nawrot, AK Sood
Nat Commun - published March 12, 2014
Ferromagnetic nanoparticles with peroxidase-like activity enhance the cleavage of biological macromolecules for biofilm elimination.
L Gao, KM Giglio, JL Nelson, H Sondermann, AJ Travis
Nanoscale - published March 7, 2014
Disruption of Helix-Capping Residues 671 and 674 Reveals a Role in HIV-1 Entry for a Specialized Hinge Segment of the Membrane Proximal External Region of gp41.
ZY Sun, Y Cheng, M Kim, L Song, J Choi, UJ Kudahl, V Brusic, B Chowdhury, L Yu, MS Seaman, G Bellot, WM Shih, G Wagner, EL Reinherz
J Mol Biol - published March 6, 2014
Analysis of Protein Interactions with Picomolar Binding Affinity by Fluorescence-Detected Sedimentation Velocity.
H Zhao, ML Mayer, P Schuck
Anal Chem - published March 5, 2014
Integrative Computational Modelling of Protein Interactions.
JP Rodrigues, AM Bonvin
FEBS J - published March 4, 2014
An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.
B Knoechel, JE Roderick, KE Williamson, J Zhu, JG Lohr, MJ Cotton, SM Gillespie, D Fernandez, M Ku, H Wang, F Piccioni, SJ Silver, M Jain, D Pearson, MJ Kluk, CJ Ott, LD Shultz, MA Brehm, DL Greiner, A Gutierrez, K Stegmaier, AL Kung, DE Root, JE Bradner, JC Aster, MA Kelliher, BE Bernstein
Nat Genet - published March 2, 2014
M4 mAChR-Mediated Modulation of Glutamatergic Transmission at Corticostriatal Synapses.
T Pancani, C Bolarinwa, Y Smith, CW Lindsley, PJ Conn, Z Xiang
ACS Chem Neurosci - published February 27, 2014
HADDOCK<sub>2P2I</sub>: A Biophysical Model for Predicting the Binding Affinity of Protein-Protein Interaction Inhibitors.
PL Kastritis, JP Rodrigues, AM Bonvin
J Chem Inf Model - published February 27, 2014
Site-Specific Integration of Amino Acid Fragments into Cyclic Peptides.
CJ White, JL Hickey, CC Scully, AK Yudin
J Am Chem Soc - published February 26, 2014
Crystal structure of the plant dual-affinity nitrate transporter NRT1.1.
J Sun, JR Bankston, J Payandeh, TR Hinds, WN Zagotta, N Zheng
Nature - published February 26, 2014
The stoichiometry of the Nup62 subcomplex of the nuclear pore in solution.
A Ulrich, JR Partridge, TU Schwartz
Mol Biol Cell - published February 26, 2014
Identification of Specific Ligand-Receptor Interactions That Govern Binding and Cooperativity of Diverse Modulators to a Common Metabotropic Glutamate Receptor 5 Allosteric Site.
KJ Gregory, ED Nguyen, C Malosh, JL Mendenhall, JZ Zic, BS Bates, MJ Noetzel, EF Squire, EM Turner, JM Rook, KA Emmitte, SR Stauffer, CW Lindsley, J Meiler, PJ Conn
ACS Chem Neurosci - published February 26, 2014
M5 Receptor Activation Produces Opposing Physiological Outcomes in Dopamine Neurons Depending on the Receptor's Location.
DJ Foster, PR Gentry, JE Lizardi-Ortiz, TM Bridges, MR Wood, CM Niswender, D Sulzer, CW Lindsley, Z Xiang, PJ Conn
J Neurosci - published February 26, 2014
Principles of ion recognition in RNA: insights from the group II intron structures.
M Marcia, AM Pyle
RNA - published February 25, 2014
Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system.
DL Akey, WC Brown, S Dutta, J Konwerski, J Jose, TJ Jurkiw, J DelProposto, CM Ogata, G Skiniotis, RJ Kuhn, JL Smith
Science - published February 21, 2014
Divergent Regulation of RyR2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants.
HS Hwang, FR Nitu, Y Yang, K Walweel, L Pereira, CN Johnson, M Faggioni, WJ Chazin, DR Laver, Jr George A, RL Cornea, DM Bers, BC Knollmann
Circ Res - published February 21, 2014
Studying Weak and Dynamic Interactions of Posttranslationally Modified Proteins using Expressed Protein Ligation.
K Tripsianes, NK Chu, A Friberg, M Sattler, CF Becker
ACS Chem Biol - published February 21, 2014
A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
Y Tian, DK Simanshu, JB Ma, JE Park, I Heo, VN Kim, DJ Patel
Mol Cell - published February 20, 2014
An unusual mode of galactose recognition by a family 32 carbohydrate-binding module.
JM Grondin, S Chitayat, E Ficko-Blean, S Houliston, CH Arrowsmith, AB Boraston, SP Smith
J Mol Biol - published February 20, 2014
Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex.
J Fan, C Shan, HB Kang, S Elf, J Xie, M Tucker, TL Gu, M Aguiar, S Lonning, H Chen, M Mohammadi, LM Britton, BA Garcia, M Alečković, Y Kang, S Kaluz, N Devi, EG Van Meir, T Hitosugi, JH Seo, S Lonial, M Gaddh, M Arellano, HJ Khoury, FR Khuri, TJ Boggon, S Kang, J Chen
Mol Cell - published February 20, 2014
Structural Analysis and Identification of PhuS as a Heme-Degrading Enzyme from Pseudomonas aeruginosa.
MJ Lee, D Schep, B McLaughlin, M Kaufmann, Z Jia
J Mol Biol - published February 20, 2014
Contribution of PDZD8 to Stabilization of the Human Immunodeficiency Virus (HIV-1) Capsid.
CA Guth, J Sodroski
J Virol - published February 19, 2014
Loss of a conserved N-linked glycosylation site in the SIV envelope glycoprotein V2 region enhances macrophage tropism by increasing CD4-independent cell-to-cell transmission.
PJ Yen, A Herschhorn, H Haim, I Salas, C Gu, J Sodroski, D Gabuzda
J Virol - published February 19, 2014
The mechanism of membrane disruption by cytotoxic amyloid oligomers formed by PrP(106-126) is dependent on bilayer composition.
P Walsh, G Vanderlee, J Yau, J Campeau, VL Sim, CM Yip, S Sharpe
J Biol Chem - published February 19, 2014
Targeting Virulence not Viability in the Search for Future Antibacterials.
B Heras, MJ Scanlon, JL Martin
Br J Clin Pharmacol - published February 19, 2014
Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A.
AO Frank, B Vangamudi, MD Feldkamp, EM Souza-Fagundes, JW Luzwick, D Cortez, ET Olejniczak, AG Waterson, OW Rossanese, WJ Chazin, SW Fesik
J Med Chem - published February 19, 2014
Evidence for an evolutionary relationship between the large adaptor nucleoporin Nup192 and karyopherins.
T Stuwe, DH Lin, LN Collins, E Hurt, A Hoelz
Proc Natl Acad Sci U S A - published February 18, 2014
RapidCaP, a Novel GEM Model for Metastatic Prostate Cancer Analysis and Therapy, Reveals Myc as a Driver of Pten-Mutant Metastasis.
H Cho, T Herzka, W Zheng, J Qi, JE Wilkinson, JE Bradner, BD Robinson, M Castillo-Martin, C Cordon-Cardo, LC Trotman
Cancer Discov - published February 18, 2014
Editorial overview: Nucleic acid movers and shakers.
K Luger, SE Phillips
Curr Opin Struct Biol - published February 18, 2014
Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels.
SG Brohawn, Z Su, R Mackinnon
Proc Natl Acad Sci U S A - published February 18, 2014
Comparison of multiple adjuvants on the stability and immunogenicity of a clade C HIV-1 gp140 trimer.
JP Nkolola, A Cheung, JR Perry, D Carter, S Reed, H Schuitemaker, MG Pau, MS Seaman, B Chen, DH Barouch
Vaccine - published February 17, 2014
Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission.
V Richter, CS Palmer, LD Osellame, AP Singh, K Elgass, DA Stroud, H Sesaki, M Kvansakul, MT Ryan
J Cell Biol - published February 17, 2014
DNA-guided DNA interference by a prokaryotic Argonaute.
DC Swarts, MM Jore, ER Westra, Y Zhu, JH Janssen, AP Snijders, Y Wang, DJ Patel, J Berenguer, SJ Brouns, J van der Oost
Nature - published February 16, 2014
Cerebral cavernous malformation proteins at a glance.
KM Draheim, OS Fisher, TJ Boggon, DA Calderwood
J Cell Sci - published February 15, 2014
Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase-dihydrofolate reductase.
H Sharma, MJ Landau, TJ Sullivan, VP Kumar, MK Dahlgren, WL Jorgensen, KS Anderson
Bioorg Med Chem Lett - published February 15, 2014
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: Development of a potent and CNS penetrant [3.1.0]-based lead.
CK Jones, DJ Sheffler, R Williams, SB Jadhav, AS Felts, RD Morrison, CM Niswender, JS Daniels, PJ Conn, CW Lindsley
Bioorg Med Chem Lett - published February 15, 2014
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: Development of a [3.3.0]-based series and other piperidine bioisosteres.
DJ Sheffler, MT Nedelovych, R Williams, SC Turner, BB Duerk, MR Robbins, SB Jadhav, CM Niswender, CK Jones, PJ Conn, RN Daniels, CW Lindsley
Bioorg Med Chem Lett - published February 15, 2014
Development of the Direct Suzuki-Miyaura Cross-Coupling of Primary B-Alkyl MIDA-boronates and Aryl Bromides.
JD St Denis, CC Scully, CF Lee, AK Yudin
Org Lett - published February 14, 2014
An antifreeze protein folds with an interior network of more than 400 semi-clathrate waters.
T Sun, FH Lin, RL Campbell, JS Allingham, PL Davies
Science - published February 14, 2014
TcaR-ssDNA complex crystal structure reveals new DNA binding mechanism of the MarR family proteins.
YM Chang, CH Ho, CK Chen, M Maestre-Reyna, MW Chang-Chien, AH Wang
Nucleic Acids Res - published February 14, 2014
Structure and Functional Analysis of YcfD, a Novel 2-Oxoglutarate/Fe<sup>2+</sup>-Dependent Oxygenase Involved in Translational Regulation in Escherichiacoli.
L van Staalduinen, SK Novakowski, Z Jia
J Mol Biol - published February 13, 2014
Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy.
Jr West AP, L Scharf, JF Scheid, F Klein, PJ Bjorkman, MC Nussenzweig
Cell - published February 13, 2014
Activation of paramyxovirus membrane fusion and virus entry.
TS Jardetzky, RA Lamb
Curr Opin Virol - published February 13, 2014
A Duplexed High-Throughput Screen to Identify Allosteric Modulators of the Glucagon-Like Peptide 1 and Glucagon Receptors.
LC Morris, EL Days, M Turney, D Mi, CW Lindsley, CD Weaver, KD Niswender
J Biomol Screen - published February 13, 2014
Structure of a myosinbulletadaptor complex and pairing by cargo.
H Shi, N Singh, F Esselborn, G Blobel
Proc Natl Acad Sci U S A - published February 12, 2014
A requirement for ER-derived COPII vesicles in phagophore initiation.
J Wang, D Tan, Y Cai, KM Reinisch, T Walz, S Ferro-Novick
Autophagy - published February 12, 2014
Structural Basis for PI(4)P-Specific Membrane Recruitment of the Legionella pneumophila Effector DrrA/SidM.
CM Del Campo, AK Mishra, YH Wang, CR Roy, PA Janmey, DG Lambright
Structure - published February 11, 2014
A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods.
M Novinec, M Korenč, A Caflisch, R Ranganathan, B Lenarčič, A Baici
Nat Commun - published February 11, 2014
A new system for naming ribosomal proteins.
N Ban, R Beckmann, JH Cate, JD Dinman, F Dragon, SR Ellis, DL Lafontaine, L Lindahl, A Liljas, JM Lipton, MA McAlear, PB Moore, HF Noller, J Ortega, VG Panse, V Ramakrishnan, CM Spahn, TA Steitz, M Tchorzewski, D Tollervey, AJ Warren, JR Williamson, D Wilson, A Yonath, M Yusupov
Curr Opin Struct Biol - published February 10, 2014
A protective chaperone for the kinetochore adaptor bub3.
Z Ji, H Yu
Dev Cell - published February 10, 2014
The RhoGEF GEF-H1 Is Required for Oncogenic RAS Signaling via KSR-1.
J Cullis, D Meiri, MJ Sandi, N Radulovich, OA Kent, M Medrano, D Mokady, J Normand, J Larose, R Marcotte, CB Marshall, M Ikura, T Ketela, J Moffat, BG Neel, AC Gingras, MS Tsao, R Rottapel
Cancer Cell - published February 10, 2014
Relating structure to evolution in class II viral membrane fusion proteins.
Y Modis
Curr Opin Virol - published February 10, 2014
Molecular basis of purinergic signal metabolism by ectonucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke.
RA Albright, DL Ornstein, W Cao, WC Chang, D Robert, M Tehan, D Hoyer, L Liu, P Stabach, G Yang, EM De La Cruz, DT Braddock
J Biol Chem - published February 7, 2014
Structure of the TbBILBO1 Protein N-terminal Domain from Trypanosoma brucei Reveals an Essential Requirement for a Conserved Surface Patch.
K Vidilaseris, B Morriswood, G Kontaxis, G Dong
J Biol Chem - published February 7, 2014
Insights into Eukaryotic Primer Synthesis from Structures of the p48 Subunit of Human DNA Primase.
S Vaithiyalingam, DR Arnett, A Aggarwal, BF Eichman, E Fanning, WJ Chazin
J Mol Biol - published February 6, 2014
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation.
M Jinek, F Jiang, DW Taylor, SH Sternberg, E Kaya, E Ma, C Anders, M Hauer, K Zhou, S Lin, M Kaplan, AT Iavarone, E Charpentier, E Nogales, JA Doudna
Science - published February 6, 2014
Structural and Functional Analysis of Human SIRT1.
AM Davenport, FM Huber, A Hoelz
J Mol Biol - published February 6, 2014
In vivo discovery of immunotherapy targets in the tumour microenvironment.
P Zhou, DR Shaffer, DA Alvarez Arias, Y Nakazaki, W Pos, AJ Torres, V Cremasco, SK Dougan, GS Cowley, K Elpek, J Brogdon, J Lamb, SJ Turley, HL Ploegh, DE Root, JC Love, G Dranoff, N Hacohen, H Cantor, KW Wucherpfennig
Nature - published February 6, 2014
Durable Remission of Pemphigus With a Fixed-Dose Rituximab Protocol.
K Heelan, F Al-Mohammedi, MJ Smith, S Knowles, P Lansang, S Walsh, NH Shear
JAMA Dermatol - published February 5, 2014
A Self-Sequestered Calmodulin-like Ca(2+) Sensor of Mitochondrial SCaMC Carrier and Its Implication to Ca(2+)-Dependent ATP-Mg/Pi Transport.
Q Yang, S Brüschweiler, JJ Chou
Structure - published February 4, 2014
Air- and Moisture-Stable Amphoteric Molecules: Enabling Reagents in Synthesis.
Z He, A Zajdlik, AK Yudin
Acc Chem Res - published February 4, 2014
Fluoroquinolone-Gyrase-DNA Complexes: Two Modes of Drug Binding.
A Mustaev, M Malik, X Zhao, N Kurepina, G Luan, LM Oppegard, H Hiasa, KR Marks, RJ Kerns, JM Berger, K Drlica
J Biol Chem - published February 4, 2014
Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers.
Y Opatowsky, I Lax, F Tome, F Bleichert, VM Unger, J Schlessinger
Proc Natl Acad Sci U S A - published February 4, 2014
Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.
K Choudhuri, J Llodrá, EW Roth, J Tsai, S Gordo, KW Wucherpfennig, LC Kam, DL Stokes, ML Dustin
Nature - published February 2, 2014
Visualizing the ai5γ group IIB intron.
S Somarowthu, M Legiewicz, KS Keating, AM Pyle
Nucleic Acids Res - published February 1, 2014
Antibodies VRC01 and 10E8 Neutralize HIV-1 with High Breadth and Potency Even with Ig-Framework Regions Substantially Reverted to Germline.
IS Georgiev, RS Rudicell, KO Saunders, W Shi, T Kirys, K McKee, S O'Dell, GY Chuang, ZY Yang, G Ofek, M Connors, JR Mascola, GJ Nabel, PD Kwong
J Immunol - published February 1, 2014
In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity.
CS Brown, MS Lee, DW Leung, T Wang, W Xu, P Luthra, M Anantpadma, RS Shabman, LM Melito, KS Macmillan, DM Borek, Z Otwinowski, P Ramanan, AJ Stubbs, DS Peterson, JM Binning, M Tonelli, MA Olson, R Davey, JM Ready, CF Basler, GK Amarasinghe
J Mol Biol - published February 1, 2014
Cancer-Derived Mutations in KEAP1 Impair NRF2 Degradation but not Ubiquitination.
BE Hast, EW Cloer, D Goldfarb, H Li, PF Siesser, F Yan, V Walter, N Zheng, DN Hayes, MB Major
Cancer Res - published February 1, 2014
Legionella pneumophila subversion of host vesicular transport by SidC effector proteins.
FA Horenkamp, S Mukherjee, E Alix, CM Schauder, AM Hubber, CR Roy, KM Reinisch
Traffic - published January 31, 2014
Arabidopsis Accelerated Cell Death 11, ACD11, Is a Ceramide-1-Phosphate Transfer Protein and Intermediary Regulator of Phytoceramide Levels.
DK Simanshu, X Zhai, D Munch, D Hofius, JE Markham, J Bielawski, A Bielawska, L Malinina, JG Molotkovsky, JW Mundy, DJ Patel, RE Brown
Cell Rep - published January 30, 2014
Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis.
E Ozkan, PH Chia, RR Wang, N Goriatcheva, D Borek, Z Otwinowski, T Walz, K Shen, KC Garcia
Cell - published January 30, 2014
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9.
SH Sternberg, S Redding, M Jinek, EC Greene, JA Doudna
Nature - published January 29, 2014
Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells.
T Fowler, P Ghatak, DH Price, R Conaway, J Conaway, CM Chiang, JE Bradner, A Shilatifard, AL Roy
PLoS One - published January 23, 2014
3-Substituted Indazoles as Configurationally Locked 4EGI-1 Mimetics and Inhibitors of the eIF4E/eIF4G Interaction.
R Yefidoff-Freedman, T Chen, R Sahoo, L Chen, G Wagner, JA Halperin, BH Aktas, M Chorev
Chembiochem - published January 23, 2014
Structural analysis and optimization of the covalent association between SpyCatcher and a peptide Tag.
L Li, JO Fierer, TA Rapoport, M Howarth
J Mol Biol - published January 23, 2014
Determinants of Heterochromatic siRNA Biogenesis and Function.
R Yu, G Jih, N Iglesias, D Moazed
Mol Cell - published January 23, 2014
Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity.
H Huang, E Zeqiraj, B Dong, BK Jha, NM Duffy, S Orlicky, N Thevakumaran, M Talukdar, MC Pillon, DF Ceccarelli, LC Wan, YC Juang, DY Mao, C Gaughan, MA Brinton, AA Perelygin, I Kourinov, A Guarné, RH Silverman, F Sicheri
Mol Cell - published January 23, 2014
SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation.
LM Johnson, J Du, CJ Hale, S Bischof, S Feng, RK Chodavarapu, X Zhong, G Marson, M Pellegrini, DJ Segal, DJ Patel, SE Jacobsen
Nature - published January 22, 2014
p120RasGAP Is a Mediator of Rho Pathway Activation and Tumorigenicity in the DLD1 Colorectal Cancer Cell Line.
SL Organ, J Hai, N Radulovich, CB Marshall, L Leung, T Sasazuki, S Shirasawa, CQ Zhu, R Navab, M Ikura, MS Tsao
PLoS One - published January 21, 2014
Mass Spectrometric Methods for the Analysis of Nucleoside-Protein Cross-Links: Application to Oxopropenyl-deoxyadenosine.
SC Shuck, KL Rose, LJ Marnett
Chem Res Toxicol - published January 21, 2014
Antipsychotic Drug-Like Effects of the Selective M<sub>4</sub> Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100.
NE Byun, M Grannan, M Bubser, RL Barry, A Thompson, J Rosanelli, R Gowrishankar, ND Kelm, S Damon, TM Bridges, BJ Melancon, JC Tarr, JT Brogan, MJ Avison, AY Deutch, J Wess, MR Wood, CW Lindsley, JC Gore, PJ Conn, CK Jones
Neuropsychopharmacology - published January 20, 2014
The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins.
G Lu, RE Middleton, H Sun, M Naniong, CJ Ott, CS Mitsiades, KK Wong, JE Bradner, Jr Kaelin WG
Science - published January 17, 2014
Transmembrane Type-2-like Cu(2+) Site in the P1B-3-type ATPase CopB: Implications for Metal Selectivity.
G Meloni, L Zhang, DC Rees
ACS Chem Biol - published January 17, 2014
The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton.
B Chen, K Brinkmann, Z Chen, CW Pak, Y Liao, S Shi, L Henry, NV Grishin, S Bogdan, MK Rosen
Cell - published January 16, 2014
Local F-actin Network Links Synapse Formation and Axon Branching.
PH Chia, B Chen, P Li, MK Rosen, K Shen
Cell - published January 16, 2014
Reversing DNA methylation: mechanisms, genomics, and biological functions.
H Wu, Y Zhang
Cell - published January 16, 2014
A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation.
KK Desai, CL Cheng, CA Bingman, Jr Phillips GN, RT Raines
Nucleic Acids Res - published January 16, 2014
An ER Protein Functionally Couples Neutral Lipid Metabolism on Lipid Droplets to Membrane Lipid Synthesis in the ER.
DF Markgraf, RW Klemm, M Junker, HK Hannibal-Bach, CS Ejsing, TA Rapoport
Cell Rep - published January 16, 2014
Targeting STAT5 in Hematological Malignancies through Inhibition of the Bromodomain and Extra-Terminal (BET) Bromodomain Protein BRD2.
S Liu, SR Walker, EA Nelson, R Cerulli, M Xiang, PA Toniolo, J Qi, RM Stone, M Wadleigh, JE Bradner, DA Frank
Mol Cancer Ther - published January 16, 2014
Dicer-related helicase 3 forms an obligate dimer for recognizing 22G-RNA.
ME Fitzgerald, A Vela, AM Pyle
Nucleic Acids Res - published January 15, 2014
The ubiquitin ligase RNF126 regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor.
CJ Smith, CJ McGlade
Exp Cell Res - published January 15, 2014
Determining the Ice-binding Planes of Antifreeze Proteins by Fluorescence-based Ice Plane Affinity.
K Basu, CP Garnham, Y Nishimiya, S Tsuda, I Braslavsky, PL Davies
J Vis Exp - published January 15, 2014
Chemical modulation of glycerolipid signaling and metabolic pathways.
SA Scott, TP Mathews, PT Ivanova, CW Lindsley, HA Brown
Biochim Biophys Acta - published January 15, 2014
Classics in chemical neuroscience: fluoxetine (prozac).
CJ Wenthur, MR Bennett, CW Lindsley
ACS Chem Neurosci - published January 15, 2014
Alkylation damage by lipid electrophiles targets functional protein systems.
SG Codreanu, JC Ullery, J Zhu, KA Tallman, WN Beavers, NA Porter, LJ Marnett, B Zhang, DC Liebler
Mol Cell Proteomics - published January 15, 2014
Functional Motions Modulating VanA Ligand Binding Unraveled by Self-Organizing Maps.
G Bouvier, N Duclert-Savatier, N Desdouits, D Meziane-Cherif, A Blondel, P Courvalin, M Nilges, TE Malliavin
J Chem Inf Model - published January 15, 2014
Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network.
S Xu, DJ Hermanson, S Banerjee, K Ghebreselasie, GM Clayton, RM Garavito, LJ Marnett
J Biol Chem - published January 14, 2014
Distinct Conformations of a Putative Translocation Element in Poliovirus Polymerase.
AJ Sholders, OB Peersen
J Mol Biol - published January 12, 2014
Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.
C Chen, BH Ha, AF Thévenin, HJ Lou, R Zhang, KY Yip, JR Peterson, M Gerstein, PM Kim, P Filippakopoulos, S Knapp, TJ Boggon, BE Turk
Mol Cell - published January 9, 2014
Mechanisms for regulating deubiquitinating enzymes.
C Wolberger
Protein Sci - published January 8, 2014
The antigen 43 structure reveals a molecular Velcro-like mechanism of autotransporter-mediated bacterial clumping.
B Heras, M Totsika, KM Peters, JJ Paxman, CL Gee, RJ Jarrott, MA Perugini, AE Whitten, MA Schembri
Proc Natl Acad Sci U S A - published January 7, 2014
Crystal Structure of the F27G AIM2 PYD Mutant and Similarities of Its Self-Association to DED/DED Interactions.
A Lu, V Kabaleeswaran, T Fu, VG Magupalli, H Wu
J Mol Biol - published January 7, 2014
Equilibrium sampling approach to the interpretation of electron density maps.
A Vitalis, A Caflisch
Structure - published January 7, 2014
Turnover-Dependent Inactivation of the Nitrogenase MoFe-Protein at High pH.
KY Yang, CA Haynes, T Spatzal, DC Rees, JB Howard
Biochemistry - published January 6, 2014
Highly reinforced structure of a C-terminal dimerization domain in von Willebrand factor.
YF Zhou, TA Springer
Blood - published January 6, 2014
Drugs for allosteric sites on receptors.
CJ Wenthur, PR Gentry, TP Mathews, CW Lindsley
Annu Rev Pharmacol Toxicol - published January 6, 2014
EttA regulates translation by binding the ribosomal E site and restricting ribosome-tRNA dynamics.
B Chen, G Boël, Y Hashem, W Ning, J Fei, C Wang, Jr Gonzalez RL, JF Hunt, J Frank
Nat Struct Mol Biol - published January 5, 2014
The ABC-F protein EttA gates ribosome entry into the translation elongation cycle.
G Boël, PC Smith, W Ning, MT Englander, B Chen, Y Hashem, AJ Testa, JJ Fischer, HJ Wieden, J Frank, Jr Gonzalez RL, JF Hunt
Nat Struct Mol Biol - published January 5, 2014
The calmodulin-like protein CML43 functions as a salicylic-acid-inducible root-specific Ca2+ sensor in Arabidopsis.
KW Bender, S Dobney, A Ogunrinde, D Chiasson, RT Mullen, HJ Teresinski, P Singh, K Munro, SP Smith, WA Snedden
Biochem J - published January 1, 2014
Synchrotron X-ray footprinting on tour.
J Bohon, R D'Mello, C Ralston, S Gupta, MR Chance
J Synchrotron Radiat - published January 1, 2014
ModBase, a database of annotated comparative protein structure models and associated resources.
U Pieper, BM Webb, GQ Dong, D Schneidman-Duhovny, H Fan, SJ Kim, N Khuri, YG Spill, P Weinkam, M Hammel, JA Tainer, M Nilges, A Sali
Nucleic Acids Res - published January 1, 2014
pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins.
M Varadi, S Kosol, P Lebrun, E Valentini, M Blackledge, AK Dunker, IC Felli, JD Forman-Kay, RW Kriwacki, R Pierattelli, J Sussman, DI Svergun, VN Uversky, M Vendruscolo, D Wishart, PE Wright, P Tompa
Nucleic Acids Res - published January 1, 2014
SAXS Merge: an automated statistical method to merge SAXS profiles using Gaussian processes.
YG Spill, SJ Kim, D Schneidman-Duhovny, D Russel, B Webb, A Sali, M Nilges
J Synchrotron Radiat - published January 1, 2014
Radioligand Binding to Nanodisc-Reconstituted Membrane Transporters Assessed by the Scintillation Proximity Assay.
ML Nasr, SK Singh
Biochemistry - published December 30, 2013
Backbone and side-chain NMR assignments for the C-terminal domain of mammalian Vps28.
TA Peterson, L Yu, RC Piper
Biomol NMR Assign - published December 24, 2013
Base-displaced intercalation of the 2-amino-3-methylimidazo[4,5-f]quinolone N2-dG adduct in the NarI DNA recognition sequence.
KM Stavros, EK Hawkins, CJ Rizzo, MP Stone
Nucleic Acids Res - published December 23, 2013
Microbial and Animal Rhodopsins: Structures, Functions, and Molecular Mechanisms.
OP Ernst, DT Lodowski, M Elstner, P Hegemann, LS Brown, H Kandori
Chem Rev - published December 23, 2013
Architecture of the large subunit of the mammalian mitochondrial ribosome.
BJ Greber, D Boehringer, A Leitner, P Bieri, F Voigts-Hoffmann, JP Erzberger, M Leibundgut, R Aebersold, N Ban
Nature - published December 22, 2013
Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism.
DP Dowling, NA Bruender, AP Young, RM McCarty, V Bandarian, CL Drennan
Nat Chem Biol - published December 22, 2013
Engineering protein thermostability using a generic activity-independent biophysical screen inside the cell.
I Asial, YX Cheng, H Engman, M Dollhopf, B Wu, P Nordlund, T Cornvik
Nat Commun - published December 19, 2013
The Interaction between Eukaryotic Initiation Factor 1A and eIF5 Retains eIF1 within Scanning Preinitiation Complexes.
RE Luna, H Arthanari, H Hiraishi, B Akabayov, L Tang, C Cox, MA Markus, LE Luna, Y Ikeda, R Watanabe, E Bedoya, C Yu, S Alikhan, G Wagner, K Asano
Biochemistry - published December 19, 2013
D14-SCFD3-dependent degradation of D53 regulates strigolactone signalling.
F Zhou, Q Lin, L Zhu, Y Ren, K Zhou, N Shabek, F Wu, H Mao, W Dong, L Gan, W Ma, H Gao, J Chen, C Yang, D Wang, J Tan, X Zhang, X Guo, J Wang, L Jiang, X Liu, W Chen, J Chu, C Yan, K Ueno, S Ito, T Asami, Z Cheng, J Wang, C Lei, H Zhai, C Wu, H Wang, N Zheng, J Wan
Nature - published December 19, 2013
STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.
PB Stathopulos, R Schindl, M Fahrner, L Zheng, GM Gasmi-Seabrook, M Muik, C Romanin, M Ikura
Nat Commun - published December 19, 2013