Publications

Recent Publications from SBGrid member labs

2014 2013 2012 2011 2010

SBGrid member labs published 124 scientific papers in the last 120 days:


Distinct BimBH3 (BimSAHB) Stapled Peptides for Structural and Cellular Studies.

GH Bird, E Gavathiotis, JL Labelle, SG Katz, LD Walensky

ACS Chem Biol - published March 21, 2014


Protein superglue that holds VWF together.

Z Jia

Blood - published March 20, 2014


Understanding Molecular Recognition of Promiscuity of Thermophilic Methionine Adenosyltransferase, sMAT from Sulfolobus solfataricus.

F Wang, S Singh, J Zhang, TD Huber, KE Helmich, M Sunkara, KA Hurley, RD Goff, CA Bingman, AJ Morris, JS Thorson, Jr Phillips GN

FEBS J - published March 20, 2014


Jaagsiekte sheep retrovirus detected in human lung cancer tissue arrays.

NM Linnerth-Petrik, SR Walsh, PN Bogner, C Morrison, SK Wootton

BMC Res Notes - published March 19, 2014


Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport.

DJ Sherman, MB Lazarus, L Murphy, C Liu, S Walker, N Ruiz, D Kahne

Proc Natl Acad Sci U S A - published March 17, 2014


Microarray Discovery of New OGT Substrates: The Medulloblastoma Oncogene OTX2 Is O-GlcNAcylated.

RF Ortiz-Meoz, Y Merbl, MW Kirschner, S Walker

J Am Chem Soc - published March 17, 2014


Assignments of RNase A by ADAPT-NMR and enhancer.

M Tonelli, CH Eller, KK Singarapu, W Lee, A Bahrami, WM Westler, RT Raines, JL Markley

Biomol NMR Assign - published March 12, 2014


Scm3 deposits a (Cse4-H4)2 tetramer onto DNA through a Cse4-H4 dimer intermediate.

ML Dechassa, K Wyns, K Luger

Nucleic Acids Res - published March 12, 2014


2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.

SY Wu, X Yang, KM Gharpure, H Hatakeyama, M Egli, MH McGuire, AS Nagaraja, TM Miyake, R Rupaimoole, CV Pecot, M Taylor, S Pradeep, M Sierant, C Rodriguez-Aguayo, HJ Choi, RA Previs, GN Armaiz-Pena, L Huang, C Martinez, T Hassell, C Ivan, V Sehgal, R Singhania, HD Han, C Su, JH Kim, HJ Dalton, C Kovvali, K Keyomarsi, NA McMillan, WW Overwijk, J Liu, JS Lee, KA Baggerly, G Lopez-Berestein, PT Ram, B Nawrot, AK Sood

Nat Commun - published March 12, 2014


Ferromagnetic nanoparticles with peroxidase-like activity enhance the cleavage of biological macromolecules for biofilm elimination.

L Gao, KM Giglio, JL Nelson, H Sondermann, AJ Travis

Nanoscale - published March 7, 2014


Disruption of Helix-Capping Residues 671 and 674 Reveals a Role in HIV-1 Entry for a Specialized Hinge Segment of the Membrane Proximal External Region of gp41.

ZY Sun, Y Cheng, M Kim, L Song, J Choi, UJ Kudahl, V Brusic, B Chowdhury, L Yu, MS Seaman, G Bellot, WM Shih, G Wagner, EL Reinherz

J Mol Biol - published March 6, 2014


Integrative Computational Modelling of Protein Interactions.

JP Rodrigues, AM Bonvin

FEBS J - published March 4, 2014


An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.

B Knoechel, JE Roderick, KE Williamson, J Zhu, JG Lohr, MJ Cotton, SM Gillespie, D Fernandez, M Ku, H Wang, F Piccioni, SJ Silver, M Jain, D Pearson, MJ Kluk, CJ Ott, LD Shultz, MA Brehm, DL Greiner, A Gutierrez, K Stegmaier, AL Kung, DE Root, JE Bradner, JC Aster, MA Kelliher, BE Bernstein

Nat Genet - published March 2, 2014


HADDOCK<sub>2P2I</sub>: A Biophysical Model for Predicting the Binding Affinity of Protein-Protein Interaction Inhibitors.

PL Kastritis, JP Rodrigues, AM Bonvin

J Chem Inf Model - published February 27, 2014


M4 mAChR-Mediated Modulation of Glutamatergic Transmission at Corticostriatal Synapses.

T Pancani, C Bolarinwa, Y Smith, CW Lindsley, PJ Conn, Z Xiang

ACS Chem Neurosci - published February 27, 2014


Crystal structure of the plant dual-affinity nitrate transporter NRT1.1.

J Sun, JR Bankston, J Payandeh, TR Hinds, WN Zagotta, N Zheng

Nature - published February 26, 2014


The stoichiometry of the Nup62 subcomplex of the nuclear pore in solution.

A Ulrich, JR Partridge, TU Schwartz

Mol Biol Cell - published February 26, 2014


Site-Specific Integration of Amino Acid Fragments into Cyclic Peptides.

CJ White, JL Hickey, CC Scully, AK Yudin

J Am Chem Soc - published February 26, 2014


M5 Receptor Activation Produces Opposing Physiological Outcomes in Dopamine Neurons Depending on the Receptor's Location.

DJ Foster, PR Gentry, JE Lizardi-Ortiz, TM Bridges, MR Wood, CM Niswender, D Sulzer, CW Lindsley, Z Xiang, PJ Conn

J Neurosci - published February 26, 2014


Identification of Specific Ligand-Receptor Interactions That Govern Binding and Cooperativity of Diverse Modulators to a Common Metabotropic Glutamate Receptor 5 Allosteric Site.

KJ Gregory, ED Nguyen, C Malosh, JL Mendenhall, JZ Zic, BS Bates, MJ Noetzel, EF Squire, EM Turner, JM Rook, KA Emmitte, SR Stauffer, CW Lindsley, J Meiler, PJ Conn

ACS Chem Neurosci - published February 26, 2014


Divergent Regulation of RyR2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants.

HS Hwang, FR Nitu, Y Yang, K Walweel, L Pereira, CN Johnson, M Faggioni, WJ Chazin, DR Laver, Jr George A, RL Cornea, DM Bers, BC Knollmann

Circ Res - published February 21, 2014


Studying Weak and Dynamic Interactions of Posttranslationally Modified Proteins using Expressed Protein Ligation.

K Tripsianes, NK Chu, A Friberg, M Sattler, CF Becker

ACS Chem Biol - published February 21, 2014


Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system.

DL Akey, WC Brown, S Dutta, J Konwerski, J Jose, TJ Jurkiw, J DelProposto, CM Ogata, G Skiniotis, RJ Kuhn, JL Smith

Science - published February 21, 2014


Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex.

J Fan, C Shan, HB Kang, S Elf, J Xie, M Tucker, TL Gu, M Aguiar, S Lonning, H Chen, M Mohammadi, LM Britton, BA Garcia, M Alečković, Y Kang, S Kaluz, N Devi, EG Van Meir, T Hitosugi, JH Seo, S Lonial, M Gaddh, M Arellano, HJ Khoury, FR Khuri, TJ Boggon, S Kang, J Chen

Mol Cell - published February 20, 2014


Structural Analysis and Identification of PhuS as a Heme-Degrading Enzyme from Pseudomonas aeruginosa.

MJ Lee, D Schep, B McLaughlin, M Kaufmann, Z Jia

J Mol Biol - published February 20, 2014


A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.

Y Tian, DK Simanshu, JB Ma, JE Park, I Heo, VN Kim, DJ Patel

Mol Cell - published February 20, 2014


An unusual mode of galactose recognition by a family 32 carbohydrate-binding module.

JM Grondin, S Chitayat, E Ficko-Blean, S Houliston, CH Arrowsmith, AB Boraston, SP Smith

J Mol Biol - published February 20, 2014


Contribution of PDZD8 to Stabilization of the Human Immunodeficiency Virus (HIV-1) Capsid.

CA Guth, J Sodroski

J Virol - published February 19, 2014


The mechanism of membrane disruption by cytotoxic amyloid oligomers formed by PrP(106-126) is dependent on bilayer composition.

P Walsh, G Vanderlee, J Yau, J Campeau, VL Sim, CM Yip, S Sharpe

J Biol Chem - published February 19, 2014


Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A.

AO Frank, B Vangamudi, MD Feldkamp, EM Souza-Fagundes, JW Luzwick, D Cortez, ET Olejniczak, AG Waterson, OW Rossanese, WJ Chazin, SW Fesik

J Med Chem - published February 19, 2014


Targeting Virulence not Viability in the Search for Future Antibacterials.

B Heras, MJ Scanlon, JL Martin

Br J Clin Pharmacol - published February 19, 2014


Editorial overview: Nucleic acid movers and shakers.

K Luger, SE Phillips

Curr Opin Struct Biol - published February 18, 2014


RapidCaP, a Novel GEM Model for Metastatic Prostate Cancer Analysis and Therapy, Reveals Myc as a Driver of Pten-Mutant Metastasis.

H Cho, T Herzka, W Zheng, J Qi, JE Wilkinson, JE Bradner, BD Robinson, M Castillo-Martin, C Cordon-Cardo, LC Trotman

Cancer Discov - published February 18, 2014


Evidence for an evolutionary relationship between the large adaptor nucleoporin Nup192 and karyopherins.

T Stuwe, DH Lin, LN Collins, E Hurt, A Hoelz

Proc Natl Acad Sci U S A - published February 18, 2014


Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels.

SG Brohawn, Z Su, R Mackinnon

Proc Natl Acad Sci U S A - published February 18, 2014


Comparison of multiple adjuvants on the stability and immunogenicity of a clade C HIV-1 gp140 trimer.

JP Nkolola, A Cheung, JR Perry, D Carter, S Reed, H Schuitemaker, MG Pau, MS Seaman, B Chen, DH Barouch

Vaccine - published February 17, 2014


Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission.

V Richter, CS Palmer, LD Osellame, AP Singh, K Elgass, DA Stroud, H Sesaki, M Kvansakul, MT Ryan

J Cell Biol - published February 17, 2014


DNA-guided DNA interference by a prokaryotic Argonaute.

DC Swarts, MM Jore, ER Westra, Y Zhu, JH Janssen, AP Snijders, Y Wang, DJ Patel, J Berenguer, SJ Brouns, J van der Oost

Nature - published February 16, 2014


Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: Development of a [3.3.0]-based series and other piperidine bioisosteres.

DJ Sheffler, MT Nedelovych, R Williams, SC Turner, BB Duerk, MR Robbins, SB Jadhav, CM Niswender, CK Jones, PJ Conn, RN Daniels, CW Lindsley

Bioorg Med Chem Lett - published February 15, 2014


Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase-dihydrofolate reductase.

H Sharma, MJ Landau, TJ Sullivan, VP Kumar, MK Dahlgren, WL Jorgensen, KS Anderson

Bioorg Med Chem Lett - published February 15, 2014


Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: Development of a potent and CNS penetrant [3.1.0]-based lead.

CK Jones, DJ Sheffler, R Williams, SB Jadhav, AS Felts, RD Morrison, CM Niswender, JS Daniels, PJ Conn, CW Lindsley

Bioorg Med Chem Lett - published February 15, 2014


Cerebral cavernous malformation proteins at a glance.

KM Draheim, OS Fisher, TJ Boggon, DA Calderwood

J Cell Sci - published February 15, 2014


An antifreeze protein folds with an interior network of more than 400 semi-clathrate waters.

T Sun, FH Lin, RL Campbell, JS Allingham, PL Davies

Science - published February 14, 2014


Development of the Direct Suzuki-Miyaura Cross-Coupling of Primary B-Alkyl MIDA-boronates and Aryl Bromides.

JD St Denis, CC Scully, CF Lee, AK Yudin

Org Lett - published February 14, 2014


TcaR-ssDNA complex crystal structure reveals new DNA binding mechanism of the MarR family proteins.

YM Chang, CH Ho, CK Chen, M Maestre-Reyna, MW Chang-Chien, AH Wang

Nucleic Acids Res - published February 14, 2014


A Duplexed High-Throughput Screen to Identify Allosteric Modulators of the Glucagon-Like Peptide 1 and Glucagon Receptors.

LC Morris, EL Days, M Turney, D Mi, CW Lindsley, CD Weaver, KD Niswender

J Biomol Screen - published February 13, 2014


Activation of paramyxovirus membrane fusion and virus entry.

TS Jardetzky, RA Lamb

Curr Opin Virol - published February 13, 2014


Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy.

Jr West AP, L Scharf, JF Scheid, F Klein, PJ Bjorkman, MC Nussenzweig

Cell - published February 13, 2014


Structure of a myosinbulletadaptor complex and pairing by cargo.

H Shi, N Singh, F Esselborn, G Blobel

Proc Natl Acad Sci U S A - published February 12, 2014


A requirement for ER-derived COPII vesicles in phagophore initiation.

J Wang, D Tan, Y Cai, KM Reinisch, T Walz, S Ferro-Novick

Autophagy - published February 12, 2014


Structural Basis for PI(4)P-Specific Membrane Recruitment of the Legionella pneumophila Effector DrrA/SidM.

CM Del Campo, AK Mishra, YH Wang, CR Roy, PA Janmey, DG Lambright

Structure - published February 11, 2014


A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods.

M Novinec, M Korenč, A Caflisch, R Ranganathan, B Lenarčič, A Baici

Nat Commun - published February 11, 2014


A new system for naming ribosomal proteins.

N Ban, R Beckmann, JH Cate, JD Dinman, F Dragon, SR Ellis, DL Lafontaine, L Lindahl, A Liljas, JM Lipton, MA McAlear, PB Moore, HF Noller, J Ortega, VG Panse, V Ramakrishnan, CM Spahn, TA Steitz, M Tchorzewski, D Tollervey, AJ Warren, JR Williamson, D Wilson, A Yonath, M Yusupov

Curr Opin Struct Biol - published February 10, 2014


The RhoGEF GEF-H1 Is Required for Oncogenic RAS Signaling via KSR-1.

J Cullis, D Meiri, MJ Sandi, N Radulovich, OA Kent, M Medrano, D Mokady, J Normand, J Larose, R Marcotte, CB Marshall, M Ikura, T Ketela, J Moffat, BG Neel, AC Gingras, MS Tsao, R Rottapel

Cancer Cell - published February 10, 2014


The eukaryotic RNA exosome.

K Januszyk, CD Lima

Curr Opin Struct Biol - published February 10, 2014


Relating structure to evolution in class II viral membrane fusion proteins.

Y Modis

Curr Opin Virol - published February 10, 2014


A protective chaperone for the kinetochore adaptor bub3.

Z Ji, H Yu

Dev Cell - published February 10, 2014


Molecular basis of purinergic signal metabolism by ectonucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke.

RA Albright, DL Ornstein, W Cao, WC Chang, D Robert, M Tehan, D Hoyer, L Liu, P Stabach, G Yang, EM De La Cruz, DT Braddock

J Biol Chem - published February 7, 2014


Structural and Functional Analysis of Human SIRT1.

AM Davenport, FM Huber, A Hoelz

J Mol Biol - published February 6, 2014


Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation.

M Jinek, F Jiang, DW Taylor, SH Sternberg, E Kaya, E Ma, C Anders, M Hauer, K Zhou, S Lin, M Kaplan, AT Iavarone, E Charpentier, E Nogales, JA Doudna

Science - published February 6, 2014


Insights into Eukaryotic Primer Synthesis from Structures of the p48 Subunit of Human DNA Primase.

S Vaithiyalingam, DR Arnett, A Aggarwal, BF Eichman, E Fanning, WJ Chazin

J Mol Biol - published February 6, 2014


In vivo discovery of immunotherapy targets in the tumour microenvironment.

P Zhou, DR Shaffer, DA Alvarez Arias, Y Nakazaki, W Pos, AJ Torres, V Cremasco, SK Dougan, GS Cowley, K Elpek, J Brogdon, J Lamb, SJ Turley, HL Ploegh, DE Root, JC Love, G Dranoff, N Hacohen, H Cantor, KW Wucherpfennig

Nature - published February 6, 2014


Durable Remission of Pemphigus With a Fixed-Dose Rituximab Protocol.

K Heelan, F Al-Mohammedi, MJ Smith, S Knowles, P Lansang, S Walsh, NH Shear

JAMA Dermatol - published February 5, 2014


Fluoroquinolone-Gyrase-DNA Complexes: Two Modes of Drug Binding.

A Mustaev, M Malik, X Zhao, N Kurepina, G Luan, LM Oppegard, H Hiasa, KR Marks, RJ Kerns, JM Berger, K Drlica

J Biol Chem - published February 4, 2014


Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers.

Y Opatowsky, I Lax, F Tome, F Bleichert, VM Unger, J Schlessinger

Proc Natl Acad Sci U S A - published February 4, 2014


Air- and Moisture-Stable Amphoteric Molecules: Enabling Reagents in Synthesis.

Z He, A Zajdlik, AK Yudin

Acc Chem Res - published February 4, 2014


Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.

K Choudhuri, J Llodrá, EW Roth, J Tsai, S Gordo, KW Wucherpfennig, LC Kam, DL Stokes, ML Dustin

Nature - published February 2, 2014


Cancer-Derived Mutations in KEAP1 Impair NRF2 Degradation but not Ubiquitination.

BE Hast, EW Cloer, D Goldfarb, H Li, PF Siesser, F Yan, V Walter, N Zheng, DN Hayes, MB Major

Cancer Res - published February 1, 2014


In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity.

CS Brown, MS Lee, DW Leung, T Wang, W Xu, P Luthra, M Anantpadma, RS Shabman, LM Melito, KS Macmillan, DM Borek, Z Otwinowski, P Ramanan, AJ Stubbs, DS Peterson, JM Binning, M Tonelli, MA Olson, R Davey, JM Ready, CF Basler, GK Amarasinghe

J Mol Biol - published February 1, 2014


Antibodies VRC01 and 10E8 Neutralize HIV-1 with High Breadth and Potency Even with Ig-Framework Regions Substantially Reverted to Germline.

IS Georgiev, RS Rudicell, KO Saunders, W Shi, T Kirys, K McKee, S O'Dell, GY Chuang, ZY Yang, G Ofek, M Connors, JR Mascola, GJ Nabel, PD Kwong

J Immunol - published February 1, 2014


Visualizing the ai5γ group IIB intron.

S Somarowthu, M Legiewicz, KS Keating, AM Pyle

Nucleic Acids Res - published February 1, 2014


Legionella pneumophila subversion of host vesicular transport by SidC effector proteins.

FA Horenkamp, S Mukherjee, E Alix, CM Schauder, AM Hubber, CR Roy, KM Reinisch

Traffic - published January 31, 2014


Arabidopsis Accelerated Cell Death 11, ACD11, Is a Ceramide-1-Phosphate Transfer Protein and Intermediary Regulator of Phytoceramide Levels.

DK Simanshu, X Zhai, D Munch, D Hofius, JE Markham, J Bielawski, A Bielawska, L Malinina, JG Molotkovsky, JW Mundy, DJ Patel, RE Brown

Cell Rep - published January 30, 2014


Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis.

E Ozkan, PH Chia, RR Wang, N Goriatcheva, D Borek, Z Otwinowski, T Walz, K Shen, KC Garcia

Cell - published January 30, 2014


DNA interrogation by the CRISPR RNA-guided endonuclease Cas9.

SH Sternberg, S Redding, M Jinek, EC Greene, JA Doudna

Nature - published January 29, 2014


3-Substituted Indazoles as Configurationally Locked 4EGI-1 Mimetics and Inhibitors of the eIF4E/eIF4G Interaction.

R Yefidoff-Freedman, T Chen, R Sahoo, L Chen, G Wagner, JA Halperin, BH Aktas, M Chorev

Chembiochem - published January 23, 2014


Determinants of Heterochromatic siRNA Biogenesis and Function.

R Yu, G Jih, N Iglesias, D Moazed

Mol Cell - published January 23, 2014


Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells.

T Fowler, P Ghatak, DH Price, R Conaway, J Conaway, CM Chiang, JE Bradner, A Shilatifard, AL Roy

PLoS One - published January 23, 2014


Structural analysis and optimization of the covalent association between SpyCatcher and a peptide Tag.

L Li, JO Fierer, TA Rapoport, M Howarth

J Mol Biol - published January 23, 2014


Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity.

H Huang, E Zeqiraj, B Dong, BK Jha, NM Duffy, S Orlicky, N Thevakumaran, M Talukdar, MC Pillon, DF Ceccarelli, LC Wan, YC Juang, DY Mao, C Gaughan, MA Brinton, AA Perelygin, I Kourinov, A Guarné, RH Silverman, F Sicheri

Mol Cell - published January 23, 2014


SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation.

LM Johnson, J Du, CJ Hale, S Bischof, S Feng, RK Chodavarapu, X Zhong, G Marson, M Pellegrini, DJ Segal, DJ Patel, SE Jacobsen

Nature - published January 22, 2014


p120RasGAP Is a Mediator of Rho Pathway Activation and Tumorigenicity in the DLD1 Colorectal Cancer Cell Line.

SL Organ, J Hai, N Radulovich, CB Marshall, L Leung, T Sasazuki, S Shirasawa, CQ Zhu, R Navab, M Ikura, MS Tsao

PLoS One - published January 21, 2014


Antipsychotic Drug-Like Effects of the Selective M<sub>4</sub> Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100.

NE Byun, M Grannan, M Bubser, RL Barry, A Thompson, J Rosanelli, R Gowrishankar, ND Kelm, S Damon, TM Bridges, BJ Melancon, JC Tarr, JT Brogan, MJ Avison, AY Deutch, J Wess, MR Wood, CW Lindsley, JC Gore, PJ Conn, CK Jones

Neuropsychopharmacology - published January 20, 2014


Transmembrane Type-2-like Cu(2+) Site in the P1B-3-type ATPase CopB: Implications for Metal Selectivity.

G Meloni, L Zhang, DC Rees

ACS Chem Biol - published January 17, 2014


The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins.

G Lu, RE Middleton, H Sun, M Naniong, CJ Ott, CS Mitsiades, KK Wong, JE Bradner, Jr Kaelin WG

Science - published January 17, 2014


Reversing DNA methylation: mechanisms, genomics, and biological functions.

H Wu, Y Zhang

Cell - published January 16, 2014


A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation.

KK Desai, CL Cheng, CA Bingman, Jr Phillips GN, RT Raines

Nucleic Acids Res - published January 16, 2014


Local F-actin Network Links Synapse Formation and Axon Branching.

PH Chia, B Chen, P Li, MK Rosen, K Shen

Cell - published January 16, 2014


An ER Protein Functionally Couples Neutral Lipid Metabolism on Lipid Droplets to Membrane Lipid Synthesis in the ER.

DF Markgraf, RW Klemm, M Junker, HK Hannibal-Bach, CS Ejsing, TA Rapoport

Cell Rep - published January 16, 2014


Targeting STAT5 in Hematological Malignancies through Inhibition of the Bromodomain and Extra-Terminal (BET) Bromodomain Protein BRD2.

S Liu, SR Walker, EA Nelson, R Cerulli, M Xiang, PA Toniolo, J Qi, RM Stone, M Wadleigh, JE Bradner, DA Frank

Mol Cancer Ther - published January 16, 2014


The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton.

B Chen, K Brinkmann, Z Chen, CW Pak, Y Liao, S Shi, L Henry, NV Grishin, S Bogdan, MK Rosen

Cell - published January 16, 2014


Alkylation damage by lipid electrophiles targets functional protein systems.

SG Codreanu, JC Ullery, J Zhu, KA Tallman, WN Beavers, NA Porter, LJ Marnett, B Zhang, DC Liebler

Mol Cell Proteomics - published January 15, 2014


Determining the Ice-binding Planes of Antifreeze Proteins by Fluorescence-based Ice Plane Affinity.

K Basu, CP Garnham, Y Nishimiya, S Tsuda, I Braslavsky, PL Davies

J Vis Exp - published January 15, 2014


Dicer-related helicase 3 forms an obligate dimer for recognizing 22G-RNA.

ME Fitzgerald, A Vela, AM Pyle

Nucleic Acids Res - published January 15, 2014


Chemical modulation of glycerolipid signaling and metabolic pathways.

SA Scott, TP Mathews, PT Ivanova, CW Lindsley, HA Brown

Biochim Biophys Acta - published January 15, 2014


Functional Motions Modulating VanA Ligand Binding Unraveled by Self-Organizing Maps.

G Bouvier, N Duclert-Savatier, N Desdouits, D Meziane-Cherif, A Blondel, P Courvalin, M Nilges, TE Malliavin

J Chem Inf Model - published January 15, 2014


Classics in chemical neuroscience: fluoxetine (prozac).

CJ Wenthur, MR Bennett, CW Lindsley

ACS Chem Neurosci - published January 15, 2014


Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network.

S Xu, DJ Hermanson, S Banerjee, K Ghebreselasie, GM Clayton, RM Garavito, LJ Marnett

J Biol Chem - published January 14, 2014


Distinct Conformations of a Putative Translocation Element in Poliovirus Polymerase.

AJ Sholders, OB Peersen

J Mol Biol - published January 12, 2014


Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.

C Chen, BH Ha, AF Thévenin, HJ Lou, R Zhang, KY Yip, JR Peterson, M Gerstein, PM Kim, P Filippakopoulos, S Knapp, TJ Boggon, BE Turk

Mol Cell - published January 9, 2014


Mechanisms for regulating deubiquitinating enzymes.

C Wolberger

Protein Sci - published January 8, 2014


Equilibrium sampling approach to the interpretation of electron density maps.

A Vitalis, A Caflisch

Structure - published January 7, 2014


The antigen 43 structure reveals a molecular Velcro-like mechanism of autotransporter-mediated bacterial clumping.

B Heras, M Totsika, KM Peters, JJ Paxman, CL Gee, RJ Jarrott, MA Perugini, AE Whitten, MA Schembri

Proc Natl Acad Sci U S A - published January 7, 2014


Crystal Structure of the F27G AIM2 PYD Mutant and Similarities of Its Self-Association to DED/DED Interactions.

A Lu, V Kabaleeswaran, T Fu, VG Magupalli, H Wu

J Mol Biol - published January 7, 2014


Turnover-Dependent Inactivation of the Nitrogenase MoFe-Protein at High pH.

KY Yang, CA Haynes, T Spatzal, DC Rees, JB Howard

Biochemistry - published January 6, 2014


Drugs for allosteric sites on receptors.

CJ Wenthur, PR Gentry, TP Mathews, CW Lindsley

Annu Rev Pharmacol Toxicol - published January 6, 2014


EttA regulates translation by binding the ribosomal E site and restricting ribosome-tRNA dynamics.

B Chen, G Boël, Y Hashem, W Ning, J Fei, C Wang, Jr Gonzalez RL, JF Hunt, J Frank

Nat Struct Mol Biol - published January 5, 2014


The ABC-F protein EttA gates ribosome entry into the translation elongation cycle.

G Boël, PC Smith, W Ning, MT Englander, B Chen, Y Hashem, AJ Testa, JJ Fischer, HJ Wieden, J Frank, Jr Gonzalez RL, JF Hunt

Nat Struct Mol Biol - published January 5, 2014


SAXS Merge: an automated statistical method to merge SAXS profiles using Gaussian processes.

YG Spill, SJ Kim, D Schneidman-Duhovny, D Russel, B Webb, A Sali, M Nilges

J Synchrotron Radiat - published January 1, 2014


pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins.

M Varadi, S Kosol, P Lebrun, E Valentini, M Blackledge, AK Dunker, IC Felli, JD Forman-Kay, RW Kriwacki, R Pierattelli, J Sussman, DI Svergun, VN Uversky, M Vendruscolo, D Wishart, PE Wright, P Tompa

Nucleic Acids Res - published January 1, 2014


The calmodulin-like protein CML43 functions as a salicylic-acid-inducible root-specific Ca2+ sensor in Arabidopsis.

KW Bender, S Dobney, A Ogunrinde, D Chiasson, RT Mullen, HJ Teresinski, P Singh, K Munro, SP Smith, WA Snedden

Biochem J - published January 1, 2014


Synchrotron X-ray footprinting on tour.

J Bohon, R D'Mello, C Ralston, S Gupta, MR Chance

J Synchrotron Radiat - published January 1, 2014


ModBase, a database of annotated comparative protein structure models and associated resources.

U Pieper, BM Webb, GQ Dong, D Schneidman-Duhovny, H Fan, SJ Kim, N Khuri, YG Spill, P Weinkam, M Hammel, JA Tainer, M Nilges, A Sali

Nucleic Acids Res - published January 1, 2014