2006 has brought many infrastructure changes, a new software branch, and many new members to the SBGrid Consortium. On the infrastructure side, we installed a new sync server to eliminate firewall problems and allow for dynamic updates. This allows us to send updates to members on the hour—any bugs can now be fixed rapidly instead of having to wait for the monthly software update. We added to our software branch by providing compilations for Mac Intel users. Since January 2006, we have had 26 new laboratories join our consortium. This, our monthly newsletter, is also a new addition—with the goal to better inform you about software updates, new members, and unique opportunities exclusive to SBGrid members. In 2007, we hope to continue growing and further improve our services. We look forward to working with you in the New Year!