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66 Member Publications for January

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1H, 15N, and 13C backbone resonance assignments of the C4b-binding region from the S. aureus extracellular adherence protein.
1. Biomol NMR Assign - published January 9, 2021
2. Pal I, Mishra N, Herrera AI, Dubey A, Arthanari H, Geisbrecht BV, Prakash O
RADX controls RAD51 filament dynamics to regulate replication fork stability.
1. Mol Cell - published January 8, 2021
2. Adolph MB, Mohamed TM, Balakrishnan S, Xue C, Morati F, Modesti M, Greene EC, Chazin WJ, Cortez D
AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells.
1. Cell Res - published January 8, 2021
2. Wang S, Qiu Z, Hou Y, Deng X, Xu W, Zheng T, Wu P, Xie S, Bian W, Zhang C, Sun Z, Liu K, Shan C, Lin A, Jiang S, Xie Y, Zhou Q, Lu L, Huang J, Li X
Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction.
1. Science - published January 8, 2021
2. Biering SB, Akey DL, Wong MP, Brown WC, Lo NTN, Puerta-Guardo H, Tramontini Gomes de Sousa F, Wang C, Konwerski JR, Espinosa DA, Bockhaus NJ, Glasner DR, Li J, Blanc SF, Juan EY, Elledge SJ, Mina MJ, Beatty PR, Smith JL, Harris E
Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers.
1. Nat Commun - published January 8, 2021
2. Shcherbakov AA, Hisao G, Mandala VS, Thomas NE, Soltani M, Salter EA, Davis JH Jr, Henzler-Wildman KA, Hong M
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
1. Nat Commun - published January 8, 2021
2. Robert Hollingsworth L, David L, Li Y, Griswold AR, Ruan J, Sharif H, Fontana P, Orth-He EL, Fu TM, Bachovchin DA, Wu H
Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase.
1. J Am Chem Soc - published January 7, 2021
2. Baidin V, Owens TW, Lazarus MB, Kahne D
Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.
1. Chem Rev - published January 7, 2021
2. Matthew AN, Leidner F, Lockbaum GJ, Henes M, Zephyr J, Hou S, Rao DN, Timm J, Rusere LN, Ragland DA, Paulsen JL, Prachanronarong K, Soumana DI, Nalivaika EA, Kurt Yilmaz N, Ali A, Schiffer CA
Primordial Protein Tails.
1. Mol Cell - published January 7, 2021
2. Brandman O, Frost A
Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.
1. Mol Cell - published January 7, 2021
2. Li T, Wu K, Yue Z, Wang Y, Zhang F, Shen H
General practitioners' deprescribing decisions in older adults with polypharmacy: a case vignette study in 31 countries.
1. BMC Geriatr - published January 7, 2021
2. Jungo KT, Mantelli S, Rozsnyai Z, Missiou A, Kitanovska BG, Weltermann B, Mallen C, Collins C, Bonfim D, Kurpas D, Petrazzuoli F, Dumitra G, Thulesius H, Lingner H, Johansen KL, Wallis K, Hoffmann K, Peremans L, Pilv L, Šter MP, Bleckwenn M, Sattler M, van der Ploeg M, Torzsa P, Kánská PB, Vinker S, Assenova R, Bravo RG, Viegas RPA, Tsopra R, Pestic SK, Gintere S, Koskela TH, Lazic V, Tkachenko V, Reeve E, Luymes C, Poortvliet RKE, Rodondi N, Gussekloo J, Streit S
Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth.
1. Immunity - published January 7, 2021
2. Chen X, Zhou T, Schmidt SD, Duan H, Cheng C, Chuang GY, Gu Y, Louder MK, Lin BC, Shen CH, Sheng Z, Zheng MX, Doria-Rose NA, Joyce MG, Shapiro L, Tian M, Alt FW, Kwong PD, Mascola JR
Design of biologically active binary protein 2D materials.
1. Nature - published January 6, 2021
2. Ben-Sasson AJ, Watson JL, Sheffler W, Johnson MC, Bittleston A, Somasundaram L, Decarreau J, Jiao F, Chen J, Mela I, Drabek AA, Jarrett SM, Blacklow SC, Kaminski CF, Hura GL, De Yoreo JJ, Kollman JM, Ruohola-Baker H, Derivery E, Baker D
Algorithmic robustness to preferred orientations in Single Particle Analysis by CryoEM.
1. J Struct Biol - published January 6, 2021
2. Sorzano COS, Semchonok D, Lin SC, Lo YC, Vilas JL, Jiménez-Moreno A, Gragera M, Vacca S, Maluenda D, Martínez M, Ramírez-Aportela E, Melero R, Cuervo A, Conesa JJ, Conesa P, Losana P, Caño LD, de la Morena JJ, Fonseca YC, Sánchez-García R, Strelak D, Fernández-Giménez E, de Isidro F, Herreros D, Kastritis PL, Marabini R, Bruce BD, Carazo JM
Crystal structure of a tick-borne flavivirus RNA-dependent RNA polymerase suggests a host adaptation hotspot in RNA viruses.
1. Nucleic Acids Res - published January 6, 2021
2. Yang J, Jing X, Yi W, Li XD, Yao C, Zhang B, Zheng Z, Wang H, Gong P
Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative.
1. Nat Commun - published January 5, 2021
2. Pan M, Zheng Q, Yu Y, Ai H, Xie Y, Zeng X, Wang C, Liu L, Zhao M
Can video games enhance surgical skills acquisition for medical students? A systematic review.
1. Surgery - published January 5, 2021
2. Gupta A, Lawendy B, Goldenberg MG, Grober E, Lee JY, Perlis N
Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins.
1. Cell Rep - published January 5, 2021
2. Shirasaki R, Matthews GM, Gandolfi S, de Matos Simoes R, Buckley DL, Raja Vora J, Sievers QL, Brüggenthies JB, Dashevsky O, Poarch H, Tang H, Bariteau MA, Sheffer M, Hu Y, Downey-Kopyscinski SL, Hengeveld PJ, Glassner BJ, Dhimolea E, Ott CJ, Zhang T, Kwiatkowski NP, Laubach JP, Schlossman RL, Richardson PG, Culhane AC, Groen RWJ, Fischer ES, Vazquez F, Tsherniak A, Hahn WC, Levy J, Auclair D, Licht JD, Keats JJ, Boise LH, Ebert BL, Bradner JE, Gray NS, Mitsiades CS
The Glo3 GAP crystal structure supports the molecular niche model for ArfGAPs in COPI coats.
1. Adv Biol Regul - published January 5, 2021
2. Xie B, Jung C, Chandra M, Engel A, Kendall AK, Jackson LP
Cold sensitivity of the SARS-CoV-2 spike ectodomain.
1. Nat Struct Mol Biol - published January 5, 2021
2. Edwards RJ, Mansouri K, Stalls V, Manne K, Watts B, Parks R, Janowska K, Gobeil SMC, Kopp M, Li D, Lu X, Mu Z, Deyton M, Oguin TH 3rd, Sprenz J, Williams W, Saunders KO, Montefiori D, Sempowski GD, Henderson R, Munir Alam S, Haynes BF, Acharya P
Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation.
1. J Gen Physiol - published January 4, 2021
2. Nathan S, Gabelli SB, Yoder JB, Srinivasan L, Aldrich RW, Tomaselli GF, Ben-Johny M, Amzel LM
A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa.
1. Mol Cell - published January 4, 2021
2. Shah M, Taylor VL, Bona D, Tsao Y, Stanley SY, Pimentel-Elardo SM, McCallum M, Bondy-Denomy J, Howell PL, Nodwell JR, Davidson AR, Moraes TF, Maxwell KL
Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival.
1. J Cell Biol - published January 4, 2021
2. Fukuda Y, Pazyra-Murphy MF, Silagi ES, Tasdemir-Yilmaz OE, Li Y, Rose L, Yeoh ZC, Vangos NE, Geffken EA, Seo HS, Adelmant G, Bird GH, Walensky LD, Marto JA, Dhe-Paganon S, Segal RA
Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer.
1. J Clin Invest - published January 4, 2021
2. Blanc V, Riordan JD, Soleymanjahi S, Nadeau JH, Nalbantoglu I, Xie Y, Molitor EA, Madison BB, Brunt EM, Mills JC, Rubin DC, Ng IO, Ha Y, Roberts LR, Davidson NO
Necator americanus Ancylostoma Secreted Protein-2 (Na-ASP-2) Binds an Ascaroside (ascr#3) in Its Fatty Acid Binding Site.
1. Front Chem - published January 4, 2021
2. El Atab O, Darwiche R, Truax NJ, Schneiter R, Hull KG, Romo D, Asojo OA
Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake.
1. Elife - published January 4, 2021
2. Schureck MA, Darling JE, Merk A, Shao J, Daggupati G, Srinivasan P, Olinares PDB, Rout MP, Chait BT, Wollenberg K, Subramaniam S, Desai SA
TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons.
1. J Clin Invest - published January 4, 2021
2. Gao D, Ciancanelli MJ, Zhang P, Harschnitz O, Bondet V, Hasek M, Chen J, Mu X, Itan Y, Cobat A, Sancho-Shimizu V, Bigio B, Lorenzo L, Ciceri G, McAlpine J, Anguiano E, Jouanguy E, Chaussabel D, Meyts I, Diamond MS, Abel L, Hur S, Smith GA, Notarangelo L, Duffy D, Studer L, Casanova JL, Zhang SY
Structural and functional characterization of the Spo11 core complex.
1. Nat Struct Mol Biol - published January 4, 2021
2. Claeys Bouuaert C, Tischfield SE, Pu S, Mimitou EP, Arias-Palomo E, Berger JM, Keeney S
A general chemical crosslinking strategy for structural analyses of weakly interacting proteins applied to preTCR-pMHC complexes.
1. J Biol Chem - published January 4, 2021
2. Mizsei R, Li X, Chen WN, Szabo M, Wang JH, Wagner G, Reinherz EL, Mallis RJ
Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin.
1. Nat Immunol - published January 4, 2021
2. Russo AJ, Vasudevan SO, Méndez-Huergo SP, Kumari P, Menoret A, Duduskar S, Wang C, Pérez Sáez JM, Fettis MM, Li C, Liu R, Wanchoo A, Chandiran K, Ruan J, Vanaja SK, Bauer M, Sponholz C, Hudalla GA, Vella AT, Zhou B, Deshmukh SD, Rabinovich GA, Rathinam VA
Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin.
1. Nat Commun - published January 4, 2021
2. Jiang D, Tonggu L, Gamal El-Din TM, Banh R, Pomès R, Zheng N, Catterall WA
Loss of wild type KRAS in KRAS^MUT lung adenocarcinoma is associated with cancer mortality and confers sensitivity to FASN inhibitors.
1. Lung Cancer - published January 2, 2021
2. Liu Y, Gao GF, Minna JD, Williams NS, Westover KD
The Card1 nuclease provides defence during type-III CRISPR immunity.
1. Nature - published January 1, 2021
2. Rostøl JT, Xie W, Kuryavyi V, Maguin P, Kao K, Froom R, Patel DJ, Marraffini LA
Structural basis for non-radical catalysis by TsrM, a radical SAM methylase.
1. Nat Chem Biol - published January 1, 2021
2. Knox HL, Chen PY, Blaszczyk AJ, Mukherjee A, Grove TL, Schwalm EL, Wang B, Drennan CL, Booker SJ
Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing.
1. Nat Commun - published January 1, 2021
2. Cléry A, Krepl M, Nguyen CKX, Moursy A, Jorjani H, Katsantoni M, Okoniewski M, Mittal N, Zavolan M, Sponer J, Allain FH
Statistically correcting dynamical electron scattering improves the refinement of protein nanocrystals, including charge refinement of coordinated metals.
1. Acta Crystallogr D Struct Biol - published January 1, 2021
2. Blum TB, Housset D, Clabbers MTB, van Genderen E, Bacia-Verloop M, Zander U, McCarthy AA, Schoehn G, Ling WL, Abrahams JP
Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms.
1. Proc Natl Acad Sci U S A - published January 1, 2021
2. Xiao X, Kim Y, Romartinez-Alonso B, Sirvydis K, Ory DS, Schwabe JWR, Jung ME, Tontonoz P
Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors.
1. Proc Natl Acad Sci U S A - published January 1, 2021
2. Cui L, Moraga I, Lerbs T, Van Neste C, Wilmes S, Tsutsumi N, Trotman-Grant AC, Gakovic M, Andrews S, Gotlib J, Darmanis S, Enge M, Quake S, Hitchcock IS, Piehler J, Garcia KC, Wernig G
Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein.
1. Proc Natl Acad Sci U S A - published January 1, 2021
2. Flower TG, Buffalo CZ, Hooy RM, Allaire M, Ren X, Hurley JH
Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes.
1. Chem Rev - published January 1, 2021
2. Milardi D, Gazit E, Radford SE, Xu Y, Gallardo RU, Caflisch A, Westermark GT, Westermark P, Rosa C, Ramamoorthy A
Mutations causing Lopes-Maciel-Rodan Syndrome are huntingtin hypomorphs.
1. Hum Mol Genet - published January 1, 2021
2. Jung R, Lee Y, Barker D, Correia K, Shin B, Loupe J, Collins RL, Lucente D, Ruliera J, Gillis T, Mysore JS, Rodan L, Picker J, Lee JM, Howland D, Lee R, Kwak S, MacDonald ME, Gusella JF, Seong IS
A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent.
1. Nat Struct Mol Biol - published January 1, 2021
2. Xiao T, Lu J, Zhang J, Johnson RI, McKay LGA, Storm N, Lavine CL, Peng H, Cai Y, Rits-Volloch S, Lu S, Quinlan BD, Farzan M, Seaman MS, Griffiths A, Chen B
Exploring the Evolutionary History of Kinetic Stability in the α-Lytic Protease Family.
1. Biochemistry - published January 1, 2021
2. Nixon CF, Lim SA, Sailer ZR, Zheludev IN, Gee CL, Kelch BA, Harms MJ, Marqusee S
Structural vaccinology of malaria transmission-blocking vaccines.
1. Expert Rev Vaccines - published January 1, 2021
2. Patel PN, Tolia NH
Targeted disruption of pi-pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity.
1. Sci Rep - published January 1, 2021
2. Covés-Datson EM, King SR, Legendre M, Swanson MD, Gupta A, Claes S, Meagher JL, Boonen A, Zhang L, Kalveram B, Raglow Z, Freiberg AN, Prichard M, Stuckey JA, Schols D, Markovitz DM
Structural biology in the fight against COVID-19.
1. Nat Struct Mol Biol - published January 1, 2021
2. Bárcena M, Barnes CO, Beck M, Bjorkman PJ, Canard B, Gao GF, Gao Y, Hilgenfeld R, Hummer G, Patwardhan A, Santoni G, Saphire EO, Schaffitzel C, Schendel SL, Smith JL, Thorn A, Veesler D, Zhang P, Zhou Q
Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice.
1. Science - published January 1, 2021
2. Cohen AA, Gnanapragasam PNP, Lee YE, Hoffman PR, Ou S, Kakutani LM, Keeffe JR, Wu HJ, Howarth M, West AP, Barnes CO, Nussenzweig MC, Bjorkman PJ
Functional refolding of the penetration protein on a non-enveloped virus.
1. Nature - published January 1, 2021
2. Herrmann T, Torres R, Salgado EN, Berciu C, Stoddard D, Nicastro D, Jenni S, Harrison SC
Real-time observation of Cas9 postcatalytic domain motions.
1. Proc Natl Acad Sci U S A - published January 1, 2021
2. Wang Y, Mallon J, Wang H, Singh D, Hyun Jo M, Hua B, Bailey S, Ha T
Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms.
1. Mol Cell - published January 1, 2021
2. Huston NC, Wan H, Strine MS, de Cesaris Araujo Tavares R, Wilen CB, Pyle AM
Chaperone-mediated autophagy sustains haematopoietic stem-cell function.
1. Nature - published January 1, 2021
2. Dong S, Wang Q, Kao YR, Diaz A, Tasset I, Kaushik S, Thiruthuvanathan V, Zintiridou A, Nieves E, Dzieciatkowska M, Reisz JA, Gavathiotis E, D'Alessandro A, Will B, Cuervo AM
Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity.
1. J Med Chem - published January 1, 2021
2. Marcyk PT, LeBlanc EV, Kuntz DA, Xue A, Ortiz F, Trilles R, Bengtson S, Kenney TMG, Huang DS, Robbins N, Williams NS, Krysan DJ, Privé GG, Whitesell L, Cowen LE, Brown LE
ENRICH: A fast method to improve the quality of flexible macromolecular reconstructions.
1. Prog Biophys Mol Biol - published January 1, 2021
2. Kazemi M, Sorzano COS, Carazo JM, Georges AD, Abrishami V, Vargas J
Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures.
1. Nat Commun - published January 1, 2021
2. Luo SC, Yeh HY, Lan WH, Wu YM, Yang CH, Chang HY, Su GC, Lee CY, Wu WJ, Li HW, Ho MC, Chi P, Tsai MD
Mithramycin and Analogs for Overcoming Cisplatin Resistance in Ovarian Cancer.
1. Biomedicines - published January 1, 2021
2. Schweer D, McCorkle JR, Rohr J, Tsodikov OV, Ueland F, Kolesar J
Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81.
1. Science - published January 1, 2021
2. Susa KJ, Rawson S, Kruse AC, Blacklow SC
Phosphorylation-dependent regulation of messenger RNA transcription, processing and translation within biomolecular condensates.
1. Curr Opin Cell Biol - published January 1, 2021
2. Nosella ML, Forman-Kay JD
HAND1 and BARX1 act as transcriptional and anatomic determinants of malignancy in gastrointestinal stromal tumor.
1. Clin Cancer Res - published January 1, 2021
2. Hemming ML, Coy S, Lin JR, Andersen JL, Przybyl J, Mazzola E, Abdelhamid Ahmed AH, van de Rijn M, Sorger PK, Armstrong SA, Demetri GD, Santagata S
Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
1. J Hematol Oncol - published January 1, 2021
2. Walker JS, Hing ZA, Harrington B, Baumhardt J, Ozer HG, Lehman A, Giacopelli B, Beaver L, Williams K, Skinner JN, Cempre CB, Sun Q, Shacham S, Stromberg BR, Summers MK, Abruzzo LV, Rassenti L, Kipps TJ, Parikh S, Kay NE, Rogers KA, Woyach JA, Coppola V, Chook YM, Oakes C, Byrd JC, Lapalombella R
A high-throughput cell-based assay pipeline for the preclinical development of bacterial DsbA inhibitors as antivirulence therapeutics.
1. Sci Rep - published January 1, 2021
2. Verderosa AD, Dhouib R, Hong Y, Anderson TK, Heras B, Totsika M
Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA.
1. Nat Microbiol - published January 1, 2021
2. Ma R, Lian T, Huang R, Renn JP, Petersen JD, Zimmerberg J, Duffy PE, Tolia NH
Structure and activation mechanism of the yeast RNA Pol II CTD kinase CTDK-1 complex.
1. Proc Natl Acad Sci U S A - published January 1, 2021
2. Xie Y, Lord CL, Clarke BP, Ivey AL, Hill PS, McDonald WH, Wente SR, Ren Y
Lactoferrin receptors in Gram-negative bacteria: an evolutionary perspective.
1. Biochem Cell Biol - published January 1, 2021
2. Ostan NKH, Moraes TF, Schryvers AB
Rosetta design with co-evolutionary information retains protein function.
1. PLoS Comput Biol - published January 1, 2021
2. Schmitz S, Ertelt M, Merkl R, Meiler J
Evolution of antibody immunity to SARS-CoV-2.
1. Nature - published January 1, 2021
2. Gaebler C, Wang Z, Lorenzi JCC, Muecksch F, Finkin S, Tokuyama M, Cho A, Jankovic M, Schaefer-Babajew D, Oliveira TY, Cipolla M, Viant C, Barnes CO, Bram Y, Breton G, Hägglöf T, Mendoza P, Hurley A, Turroja M, Gordon K, Millard KG, Ramos V, Schmidt F, Weisblum Y, Jha D, Tankelevich M, Martinez-Delgado G, Yee J, Patel R, Dizon J, Unson-O'Brien C, Shimeliovich I, Robbiani DF, Zhao Z, Gazumyan A, Schwartz RE, Hatziioannou T, Bjorkman PJ, Mehandru S, Bieniasz PD, Caskey M, Nussenzweig MC
Atomic structures of respiratory complex III₂, complex IV, and supercomplex III₂-IV from vascular plants.
1. Elife - published January 1, 2021
2. Maldonado M, Guo F, Letts JA