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111 Member Publications for July

Previous Month

Corrigendum: A Markerless Method for Genome Engineering in Zymomonas mobilis ZM4.
1. Front Microbiol - published July 19, 2021
2. Lal PB, Wells FM, Lyu Y, Ghosh IN, Landick R, Kiley PJ
Selective Nutrient Transport in Bacteria: Multicomponent Transporter Systems Reign Supreme.
1. Front Mol Biosci - published July 16, 2021
2. Davies JS, Currie MJ, Wright JD, Newton-Vesty MC, North RA, Mace PD, Allison JR, Dobson RCJ
Disabling the Nuclear Translocalization of RelA/NF-κB by a Small Molecule Inhibits Triple-Negative Breast Cancer Growth.
1. Breast Cancer (Dove Med Press) - published July 15, 2021
2. Kanzaki H, Chatterjee A, Hossein Nejad Ariani H, Zhang X, Chung S, Deng N, Ramanujan VK, Cui X, Greene MI, Murali R
Glycolysis-Related Gene Expression Profiling Screen for Prognostic Risk Signature of Pancreatic Ductal Adenocarcinoma.
1. Front Genet - published July 12, 2021
2. Song W, He X, Gong P, Yang Y, Huang S, Zeng Y, Wei L, Zhang J
Reining in BTK: Interdomain Interactions and Their Importance in the Regulatory Control of BTK.
1. Front Cell Dev Biol - published July 12, 2021
2. Kueffer LE, Joseph RE, Andreotti AH
Ligand-binding and -scavenging of the chemerin receptor GPR1.
1. Cell Mol Life Sci - published July 9, 2021
2. Fischer TF, Czerniak AS, Weiß T, Schoeder CT, Wolf P, Seitz O, Meiler J, Beck-Sickinger AG
Ultrastructure of influenza virus ribonucleoprotein complexes during viral RNA synthesis.
1. Commun Biol - published July 9, 2021
2. Nakano M, Sugita Y, Kodera N, Miyamoto S, Muramoto Y, Wolf M, Noda T
Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs.
1. Nat Commun - published July 9, 2021
2. Xu K, Wang Y, Shen CH, Chen Y, Zhang B, Liu K, Tsybovsky Y, Wang S, Farney SK, Gorman J, Stephens T, Verardi R, Yang Y, Zhou T, Chuang GY, Lanzavecchia A, Piccoli L, Kwong PD
A Multitask Deep-Learning Method for Predicting Membrane Associations and Secondary Structures of Proteins.
1. J Proteome Res - published July 8, 2021
2. Li B, Mendenhall J, Capra JA, Meiler J
Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor BIO-32546.
1. ACS Med Chem Lett - published July 8, 2021
2. Ma B, Zhang L, Sun L, Xin Z, Kumaravel G, Marcotte D, Chodaparambil JV, Wang Q, Wehr A, Jing J, Hong VS, Wang T, Huang C, Shao Z, Mi S
K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle.
1. Nat Chem Biol - published July 8, 2021
2. Yu Y, Zheng Q, Erramilli SK, Pan M, Park S, Xie Y, Li J, Fei J, Kossiakoff AA, Liu L, Zhao M
METTL3 inhibitors for epitranscriptomic modulation of cellular processes.
1. ChemMedChem - published July 8, 2021
2. Moroz-Omori EV, Huang D, Bedi RK, Cheriyamkunnel SJ, Bochenkova E, Dolbois A, Rzeczkowski MD, Li Y, Wiedmer L, Caflisch A
Genome-encoded cytoplasmic double-stranded RNAs, found in C9ORF72 ALS-FTD brain, propagate neuronal loss.
1. Sci Transl Med - published July 7, 2021
2. Rodriguez S, Sahin A, Schrank BR, Al-Lawati H, Costantino I, Benz E, Fard D, Albers AD, Cao L, Gomez AC, Evans K, Ratti E, Cudkowicz M, Frosch MP, Talkowski M, Sorger PK, Hyman BT, Albers MW
Ribosome-associated quality control and CAT tailing.
1. Crit Rev Biochem Mol Biol - published July 7, 2021
2. Howard CJ, Frost A
Sexual arousal gates visual processing during Drosophila courtship.
1. Nature - published July 7, 2021
2. Hindmarsh Sten T, Li R, Otopalik A, Ruta V
Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies.
1. Nat Commun - published July 7, 2021
2. Greaney AJ, Starr TN, Barnes CO, Weisblum Y, Schmidt F, Caskey M, Gaebler C, Cho A, Agudelo M, Finkin S, Wang Z, Poston D, Muecksch F, Hatziioannou T, Bieniasz PD, Robbiani DF, Nussenzweig MC, Bjorkman PJ, Bloom JD
Structural basis of the stereoselective formation of the spirooxindole ring in the biosynthesis of citrinadins.
1. Nat Commun - published July 6, 2021
2. Liu Z, Zhao F, Zhao B, Yang J, Ferrara J, Sankaran B, Venkataram Prasad BV, Kundu BB, Phillips GN Jr, Gao Y, Hu L, Zhu T, Gao X
Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease.
1. Cell Rep - published July 6, 2021
2. Fonseca-Ornelas L, Viennet T, Rovere M, Jiang H, Liu L, Nuber S, Ericsson M, Arthanari H, Selkoe DJ
Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.
1. J Cell Biol - published July 5, 2021
2. Chandrakumar AA, Coyaud É, Marshall CB, Ikura M, Raught B, Rottapel R
Structure of a mammalian sperm cation channel complex.
1. Nature - published July 5, 2021
2. Lin S, Ke M, Zhang Y, Yan Z, Wu J
In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission.
1. Elife - published July 5, 2021
2. Haugh KA, Ladinsky MS, Ullah I, Stone HM, Pi R, Gilardet A, Grunst MW, Kumar P, Bjorkman PJ, Mothes W, Uchil PD
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients.
1. J Exp Med - published July 5, 2021
2. Le Coz C, Nguyen DN, Su C, Nolan BE, Albrecht AV, Xhani S, Sun D, Demaree B, Pillarisetti P, Khanna C, Wright F, Chen PA, Yoon S, Stiegler AL, Maurer K, Garifallou JP, Rymaszewski A, Kroft SH, Olson TS, Seif AE, Wertheim G, Grant SFA, Vo LT, Puck JM, Sullivan KE, Routes JM, Zakharova V, Shcherbina A, Mukhina A, Rudy NL, Hurst ACE, Atkinson TP, Boggon TJ, Hakonarson H, Abate AR, Hajjar J, Nicholas SK, Lupski JR, Verbsky J, Chinn IK, Gonzalez MV, Wells AD, Marson A, Poon GMK, Romberg N
Recombinant SARS-CoV-2 envelope protein traffics to the trans-Golgi network following amphipol-mediated delivery into human cells.
1. J Biol Chem - published July 5, 2021
2. Hutchison JM, Capone R, Luu DD, Shah KH, Hadziselimovic A, Van Horn WD, Sanders CR
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2.
1. Science - published July 3, 2021
2. Tummino TA, Rezelj VV, Fischer B, Fischer A, O'Meara MJ, Monel B, Vallet T, White KM, Zhang Z, Alon A, Schadt H, O'Donnell HR, Lyu J, Rosales R, McGovern BL, Rathnasinghe R, Jangra S, Schotsaert M, Galarneau JR, Krogan NJ, Urban L, Shokat KM, Kruse AC, García-Sastre A, Schwartz O, Moretti F, Vignuzzi M, Pognan F, Shoichet BK
The SARS-CoV-2 Programmed -1 Ribosomal Frameshifting Element Crystal Structure Solved to 2.09 Å Using Chaperone-Assisted RNA Crystallography.
1. ACS Chem Biol - published July 3, 2021
2. Roman C, Lewicka A, Koirala D, Li NS, Piccirilli JA
McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation.
1. Elife - published July 3, 2021
2. Hajdusits B, Suskiewicz MJ, Hundt N, Meinhart A, Kurzbauer R, Leodolter J, Kukura P, Clausen T
A plug-and-play platform of ratiometric bioluminescent sensors for homogeneous immunoassays.
1. Nat Commun - published July 2, 2021
2. Ni Y, Rosier BJHM, van Aalen EA, Hanckmann ETL, Biewenga L, Pistikou AM, Timmermans B, Vu C, Roos S, Arts R, Li W, de Greef TFA, van Borren MMGJ, van Kuppeveld FJM, Bosch BJ, Merkx M
Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses.
1. Front Immunol - published July 2, 2021
2. Bullen G, Galson JD, Hall G, Villar P, Moreels L, Ledsgaard L, Mattiuzzo G, Bentley EM, Masters EW, Tang D, Millett S, Tongue D, Brown R, Diamantopoulos I, Parthiban K, Tebbutt C, Leah R, Chaitanya K, Ergueta-Carballo S, Pazeraitis D, Surade SB, Ashiru O, Crippa L, Cowan R, Bowler MW, Campbell JI, Lee WJ, Carr MD, Matthews D, Pfeffer P, Hufton SE, Sawmynaden K, Osbourn J, McCafferty J, Karatt-Vellatt A
Site-Specific Steric Control of SARS-CoV-2 Spike Glycosylation.
1. Biochemistry - published July 2, 2021
2. Allen JD, Chawla H, Samsudin F, Zuzic L, Shivgan AT, Watanabe Y, He WT, Callaghan S, Song G, Yong P, Brouwer PJM, Song Y, Cai Y, Duyvesteyn HME, Malinauskas T, Kint J, Pino P, Wurm MJ, Frank M, Chen B, Stuart DI, Sanders RW, Andrabi R, Burton DR, Li S, Bond PJ, Crispin M
Validation and classification of RNA binding proteins identified by mRNA interactome capture.
1. RNA - published July 2, 2021
2. Vaishali V, Dimitrova-Paternoga L, Haubrich K, Sun M, Ephrussi A, Hennig J
Nodal modulator (NOMO) is required to sustain endoplasmic reticulum morphology.
1. J Biol Chem - published July 2, 2021
2. Amaya C, Cameron CJ, Devarkar SC, Seager SJ, Gerstein MB, Xiong Y, Schlieker C
Mechanisms underlying genetic susceptibility to Multisystem Inflammatory Syndrome in Children (MIS-C).
1. J Allergy Clin Immunol - published July 2, 2021
2. Chou J, Platt CD, Habiballah S, Nguyen AA, Elkins M, Weeks S, Peters Z, Day-Lewis M, Novak T, Armant M, Williams L, Rockowitz S, Sliz P, Williams DA, Randolph AG, Geha RS, Taking on COVID-19 Together Study Investigators., Almutairi A, Jaber F, Banzon T, Roberts J, Halyabar O, Lo M, Kahn S, Henderson LA, Lee PY, Son MB, Cheng L
Sorting of cadherin-catenin-associated proteins into individual clusters.
1. Proc Natl Acad Sci U S A - published July 2, 2021
2. Troyanovsky RB, Sergeeva AP, Indra I, Chen CS, Kato R, Shapiro L, Honig B, Troyanovsky SM
Large-conductance calcium-activated K⁺ channels, rather than K_ATP channels, mediate the inhibitory effects of nitric oxide on mouse lymphatic pumping.
1. Br J Pharmacol - published July 2, 2021
2. Kim HJ, Li M, Nichols CG, Davis MJ
Author Correction: Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs.
1. Nat Struct Mol Biol - published July 2, 2021
2. Kern DM, Sorum B, Mali SS, Hoel CM, Sridharan S, Remis JP, Toso DB, Kotecha A, Bautista DM, Brohawn SG
Correlated Motions in Structural Biology.
1. Biochemistry - published July 2, 2021
2. Xu D, Meisburger SP, Ando N
AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms.
1. Blood - published July 2, 2021
2. Morande PE, Yan XJ, Sepulveda J, Seija N, Marquez ME, Sotelo N, Abreu C, Crispo M, Fernández-Graña G, Rego N, Bois T, Methot SP, Palacios F, Remedi V, Rai KR, Buschiazzo A, Di Noia JM, Navarrete MA, Chiorazzi N, Oppezzo P
A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice.
1. Sci Transl Med - published July 2, 2021
2. Boudreau MW, Duraki D, Wang L, Mao C, Kim JE, Henn MA, Tang B, Fanning SW, Kiefer J, Tarasow TM, Bruckheimer EM, Moreno R, Mousses S, Greene GL, Roy EJ, Park BH, Fan TM, Nelson ER, Hergenrother PJ, Shapiro DJ
Electron paramagnetic resonance spectroscopy on G-protein-coupled receptors: Adopting strategies from related model systems.
1. Curr Opin Struct Biol - published July 2, 2021
2. Reichenwallner J, Liu B, Balo AR, Ou WL, Ernst OP
Ongoing global and regional adaptive evolution of SARS-CoV-2.
1. Proc Natl Acad Sci U S A - published July 2, 2021
2. Rochman ND, Wolf YI, Faure G, Mutz P, Zhang F, Koonin EV
Induced proximity tools for precise manipulation of lipid signaling.
1. Curr Opin Chem Biol - published July 2, 2021
2. Tei R, Baskin JM
Half-life extension of efficiently produced DARPin serum albumin fusions as a function of FcRn affinity and recycling.
1. Eur J Pharm Biopharm - published July 2, 2021
2. Merten H, Brandl F, Zimmermann M, Schaefer JV, Irpinio L, M K Sand K, Nilsen J, Andersen JT, Zangemeister-Wittke U, Plückthun A
Breakers and amplifiers in chromatin circuitry: acetylation and ubiquitination control the heterochromatin machinery.
1. Curr Opin Struct Biol - published July 2, 2021
2. Bailey LT, Northall SJ, Schalch T
O-Linked-N-Acetylglucosaminylation of the RNA-Binding Protein EWS N-Terminal Low Complexity Region Reduces Phase Separation and Enhances Condensate Dynamics.
1. J Am Chem Soc - published July 2, 2021
2. Nosella ML, Tereshchenko M, Pritišanac I, Chong PA, Toretsky JA, Lee HO, Forman-Kay JD
Purification of MBP fusion proteins using engineered DARPin affinity matrix.
1. Int J Biol Macromol - published July 2, 2021
2. Nemergut M, Škrabana R, Berta M, Plückthun A, Sedlák E
Lentiviral-driven discovery of cancer drug resistance mutations.
1. Cancer Res - published July 2, 2021
2. Yenerall P, Kollipara RK, Avila K, Peyton M, Eide CA, Bottomly D, McWeeney SK, Liu Y, Westover KD, Druker BJ, Minna JD, Kittler R
Insane in the membrane: developments in protein folding, protein transport, and signaling by GPCRs.
1. Curr Opin Struct Biol - published July 2, 2021
2. Maher MJ, Ernst OP
Quorum sensing governs a transmissive Legionella subpopulation at the pathogen vacuole periphery.
1. EMBO Rep - published July 2, 2021
2. Striednig B, Lanner U, Niggli S, Katic A, Vormittag S, Brülisauer S, Hochstrasser R, Kaech A, Welin A, Flieger A, Ziegler U, Schmidt A, Hilbi H, Personnic N
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.
1. Nat Chem Biol - published July 2, 2021
2. Grabarczyk DB, Petrova OA, Deszcz L, Kurzbauer R, Murphy P, Ahel J, Vogel A, Gogova R, Faas V, Kordic D, Schleiffer A, Meinhart A, Imre R, Lehner A, Neuhold J, Bader G, Stolt-Bergner P, Böttcher J, Wolkerstorfer B, Fischer G, Grishkovskaya I, Haselbach D, Kessler D, Clausen T
Structure and function of an Arabidopsis thaliana sulfate transporter.
1. Nat Commun - published July 2, 2021
2. Wang L, Chen K, Zhou M
Mitochondrial damage in renal epithelial cells is potentiated by protein exposure in propionic aciduria.
1. J Inherit Metab Dis - published July 2, 2021
2. Schumann A, Belche V, Schaller K, Grünert SC, Kaech A, Baumgartner MR, Kölker S, Hannibal L, Spiekerkoetter U
Structure and analysis of nanobody binding to the human ASIC1a ion channel.
1. Elife - published July 2, 2021
2. Wu Y, Chen Z, Sigworth FJ, Canessa CM
Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy.
1. Elife - published July 2, 2021
2. Weber MS, Eibauer M, Sivagurunathan S, Magin TM, Goldman RD, Medalia O
Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates.
1. Sci Transl Med - published July 2, 2021
2. Francica JR, Flynn BJ, Foulds KE, Noe AT, Werner AP, Moore IN, Gagne M, Johnston TS, Tucker C, Davis RL, Flach B, O'Connell S, Andrew SF, Lamb E, Flebbe DR, Nurmukhambetova ST, Donaldson MM, Todd JM, Zhu AL, Atyeo C, Fischinger S, Gorman MJ, Shin S, Edara VV, Floyd K, Lai L, Boyoglu-Barnum S, Van De Wetering R, Taylor A, McCarthy E, Lecouturier V, Ruiz S, Berry C, Tibbitts T, Andersen H, Cook A, Dodson A, Pessaint L, Van Ry A, Koutsoukos M, Gutzeit C, Teng IT, Zhou T, Li D, Haynes BF, Kwong PD, McDermott A, Lewis MG, Fu TM, Chicz R, van der Most R, Corbett KS, Suthar MS, Alter G, Roederer M, Sullivan NJ, Douek DC, Graham BS, Casimiro D, Seder RA
Probing the transport of Ni(II) ions through the internal tunnels of the Helicobacter pylori UreDFG multimeric protein complex.
1. J Inorg Biochem - published July 2, 2021
2. Masetti M, Bertazzo M, Recanatini M, Ciurli S, Musiani F
Cryo-EM structure of human Wntless in complex with Wnt3a.
1. Nat Commun - published July 2, 2021
2. Zhong Q, Zhao Y, Ye F, Xiao Z, Huang G, Xu M, Zhang Y, Zhan X, Sun K, Wang Z, Cheng S, Feng S, Zhao X, Zhang J, Lu P, Xu W, Zhou Q, Ma D
Allosteric Inhibition of a Vesicular Glutamate Transporter by an Isoform-Specific Antibody.
1. Biochemistry - published July 2, 2021
2. Eriksen J, Li F, Stroud RM, Edwards RH
Assessing the filtration efficiency and regulatory status of N95s and nontraditional filtering face-piece respirators available during the COVID-19 pandemic.
1. BMC Infect Dis - published July 2, 2021
2. Plana D, Tian E, Cramer AK, Yang H, Carmack MM, Sinha MS, Bourgeois FT, Yu SH, Masse P, Boyer J, Kim M, Mo J, LeBoeuf NR, Li J, Sorger PK
Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations.
1. J Mol Biol - published July 2, 2021
2. Miersch S, Li Z, Saberianfar R, Ustav M, Brett Case J, Blazer L, Chen C, Ye W, Pavlenco A, Gorelik M, Garcia Perez J, Subramania S, Singh S, Ploder L, Ganaie S, Chen RE, Leung DW, Pandolfi PP, Novelli G, Matusali G, Colavita F, Capobianchi MR, Jain S, Gupta JB, Amarasinghe GK, Diamond MS, Rini J, Sidhu SS
Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity.
1. Nat Commun - published July 2, 2021
2. Zhang Y, Brown K, Yu Y, Ibrahim Z, Zandian M, Xuan H, Ingersoll S, Lee T, Ebmeier CC, Liu J, Panne D, Shi X, Ren X, Kutateladze TG
TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma.
1. Cancer Cell - published July 2, 2021
2. Seong BKA, Dharia NV, Lin S, Donovan KA, Chong S, Robichaud A, Conway A, Hamze A, Ross L, Alexe G, Adane B, Nabet B, Ferguson FM, Stolte B, Wang EJ, Sun J, Darzacq X, Piccioni F, Gray NS, Fischer ES, Stegmaier K
Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer.
1. NPJ Precis Oncol - published July 1, 2021
2. Nakamura IT, Kohsaka S, Ikegami M, Ikeuchi H, Ueno T, Li K, Beyett TS, Koyama T, Shimizu T, Yamamoto N, Takahashi F, Takahashi K, Eck MJ, Mano H
CRISPR-based diagnostics.
1. Nat Biomed Eng - published July 1, 2021
2. Kaminski MM, Abudayyeh OO, Gootenberg JS, Zhang F, Collins JJ
Activation of the Anti-Oxidative Stress Response Reactivates Latent HIV-1 Through the Mitochondrial Antiviral Signaling Protein Isoform MiniMAVS.
1. Front Immunol - published July 1, 2021
2. Sarabia I, Novis CL, Macedo AB, Takata H, Nell R, Kakazu JC, Furler RL, Shakya B, Schubert HL, Hill CP, DePaula-Silva AB, Spivak AM, Trautmann L, Planelles V, Bosque A
Flexible microtubule anchoring modulates the bi-directional motility of the kinesin-5 Cin8.
1. Cell Mol Life Sci - published July 1, 2021
2. Pandey H, Singh SK, Sadan M, Popov M, Singh M, Davidov G, Inagaki S, Al-Bassam J, Zarivach R, Rosenfeld SS, Gheber L
Structure-Guided Design of a "Bump-and-Hole" Bromodomain-Based Degradation Tag.
1. J Med Chem - published July 1, 2021
2. Nowak RP, Xiong Y, Kirmani N, Kalabathula J, Donovan KA, Eleuteri NA, Yuan JC, Fischer ES
Diversity, Equity, and Inclusion in The Journal of Pediatrics.
1. J Pediatr - published July 1, 2021
2. Fisher PG, Long SS, Cole CR, Cohran VC, Fuentes-Afflick E, Krantz I, Lion KC, McDevitt M, Ott MA, Ross LF, Toltzis P, Washington RL, Welch TR, Balistreri WF
Accurate prediction of protein structures and interactions using a three-track neural network.
1. Science - published July 1, 2021
2. Baek M, DiMaio F, Anishchenko I, Dauparas J, Ovchinnikov S, Lee GR, Wang J, Cong Q, Kinch LN, Schaeffer RD, Millán C, Park H, Adams C, Glassman CR, DeGiovanni A, Pereira JH, Rodrigues AV, van Dijk AA, Ebrecht AC, Opperman DJ, Sagmeister T, Buhlheller C, Pavkov-Keller T, Rathinaswamy MK, Dalwadi U, Yip CK, Burke JE, Garcia KC, Grishin NV, Adams PD, Read RJ, Baker D
BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells.
1. Nat Immunol - published July 1, 2021
2. Seo H, González-Avalos E, Zhang W, Ramchandani P, Yang C, Lio CJ, Rao A, Hogan PG
Chemo-proteomics exploration of HDAC degradability by small molecule degraders.
1. Cell Chem Biol - published July 1, 2021
2. Xiong Y, Donovan KA, Eleuteri NA, Kirmani N, Yue H, Razov A, Krupnick NM, Nowak RP, Fischer ES
Drug discovery in the era of cryo-electron microscopy.
1. Trends Biochem Sci - published July 1, 2021
2. Robertson MJ, Meyerowitz JG, Skiniotis G
Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition.
1. Mol Cell - published July 1, 2021
2. Hunkeler M, Jin CY, Ma MW, Monda JK, Overwijn D, Bennett EJ, Fischer ES
Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells.
1. Mol Cell - published July 1, 2021
2. Chen D, Xia S, Zhang R, Li Y, Famulare CA, Fan H, Wu R, Wang M, Zhu AC, Elf SE, Su R, Dong L, Arellano M, Blum WG, Mao H, Lonial S, Stock W, Odenike O, Le Beau M, Boggon TJ, He C, Chen J, Gao X, Levine RL, Chen J
Illustrated State-of-the-Art Capsules of the ISTH 2020 Congress.
1. Res Pract Thromb Haemost - published July 1, 2021
2. Krishnaswamy S, Ageno W, Arabi Y, Barbui T, Cannegieter S, Carrier M, Cleuren AC, Collins P, Panicot-Dubois L, Freedman JE, Freson K, Hogg P, James AH, Kretz CA, Lavin M, Leebeek FWG, Li W, Maas C, Machlus K, Makris M, Martinelli I, Medved L, Neerman-Arbez M, O'Donnell JS, O'Sullivan J, Rajpurkar M, Schroeder V, Spiegel PC Jr, Stanworth SJ, Green L, Undas A
Body site distribution of pediatric-onset morphea and association with extracutaneous manifestations.
1. J Am Acad Dermatol - published July 1, 2021
2. Chiu YE, Shmuylovich L, Kiguradze T, Anderson K, Sibbald C, Tollefson M, Kunzler E, Tom WL, Bond K, Ahmad RC, Garcia-Romero MT, Irfan M, Kollman K, Hunt R, Stein SL, Arkin L, Wong V, Pope E, Jacobe H, Brandling-Bennett HA, Cordoro KM, Bercovitch L, Rangel SM, Liu X, Szabo A, Paller AS
Combined computational and cellular screening identifies synergistic inhibition of SARS-CoV-2 by lenvatinib and remdesivir.
1. J Gen Virol - published July 1, 2021
2. Pohl MO, Busnadiego I, Marrafino F, Wiedmer L, Hunziker A, Fernbach S, Glas I, Moroz-Omori EV, Hale BG, Caflisch A, Stertz S
FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.
1. Sci Adv - published July 1, 2021
2. Birsa N, Ule AM, Garone MG, Tsang B, Mattedi F, Chong PA, Humphrey J, Jarvis S, Pisiren M, Wilkins OG, Nosella ML, Devoy A, Bodo C, de la Fuente RF, Fisher EMC, Rosa A, Viero G, Forman-Kay JD, Schiavo G, Fratta P
In Regard to Salama et al.
1. Int J Radiat Oncol Biol Phys - published July 1, 2021
2. Perkins S, Hallahan DE, Schwarz JK
PROGRESSION OF SCOTOPIC SINGLE-FLASH ELECTRORETINOGRAPHY IN THE STAGES OF CAPN5 VITREORETINOPATHY.
1. Retin Cases Brief Rep - published July 1, 2021
2. Tang PH, Kinnick TR, Folk JC, Mahajan M, Bassuk AG, Tsang SH, Mahajan VB
Reopening International Borders without Quarantine: Contact Tracing Integrated Policy against COVID-19.
1. Int J Environ Res Public Health - published July 1, 2021
2. Yu Z, Zhu X, Liu X, Wei T, Yuan HY, Xu Y, Zhu R, He H, Wang H, Wong MS, Jia P, Guo S, Shi W, Chen W
Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration.
1. Adv Sci (Weinh) - published July 1, 2021
2. Arnold F, Mahaddalkar PU, Kraus JM, Zhong X, Bergmann W, Srinivasan D, Gout J, Roger E, Beutel AK, Zizer E, Tharehalli U, Daiss N, Russell R, Perkhofer L, Oellinger R, Lin Q, Azoitei N, Weiss FU, Lerch MM, Liebau S, Katz SF, Lechel A, Rad R, Seufferlein T, Kestler HA, Ott M, Sharma AD, Hermann PC, Kleger A
Crystal structures of HER3 extracellular domain 4 in complex with the designed ankyrin-repeat protein D5.
1. Acta Crystallogr F Struct Biol Commun - published July 1, 2021
2. Radom F, Vonrhein C, Mittl PRE, Plückthun A
The Present and Future of Mitochondrial-Based Therapeutics for Eye Disease.
1. Transl Vis Sci Technol - published July 1, 2021
2. Ji MH, Kreymerman A, Belle K, Ghiam BK, Muscat SP, Mahajan VB, Enns GM, Mercola M, Wood EH
High-resolution characterization of gene function using single-cell CRISPR tiling screen.
1. Nat Commun - published July 1, 2021
2. Yang L, Chan AKN, Miyashita K, Delaney CD, Wang X, Li H, Pokharel SP, Li S, Li M, Xu X, Lu W, Liu Q, Mattson N, Chen KY, Wang J, Yuan YC, Horne D, Rosen ST, Soto-Feliciano Y, Feng Z, Hoshii T, Xiao G, Müschen M, Chen J, Armstrong SA, Chen CW
Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT.
1. J Exp Clin Cancer Res - published July 1, 2021
2. Li Q, Zhou ZW, Duan W, Qian CY, Wang SN, Deng MS, Zi D, Wang JM, Mao CY, Song G, Wang D, Westover KD, Xu CX
Display of the human mucinome with defined O-glycans by gene engineered cells.
1. Nat Commun - published July 1, 2021
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Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants.
1. Science - published July 1, 2021
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Beyond PKA: Evolutionary and Structural Insights that Define a Docking and Dimerization Domain Superfamily.
1. J Biol Chem - published July 1, 2021
2. Dahlin HR, Zheng N, Scott JD
Secondary rewards acquire enhanced incentive motivation via increasing anticipatory activity of the lateral orbitofrontal cortex.
1. Brain Struct Funct - published July 1, 2021
2. Yang X, Liu X, Zeng Y, Wu R, Zhao W, Xin F, Yao S, Kendrick KM, Ebstein RP, Becker B
Author Correction: Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape.
1. Nat Commun - published July 1, 2021
2. Ku Z, Xie X, Davidson E, Ye X, Su H, Menachery VD, Li Y, Yuan Z, Zhang X, Muruato AE, I Escuer AG, Tyrell B, Doolan K, Doranz BJ, Wrapp D, Bates PF, McLellan JS, Weiss SR, Zhang N, Shi PY, An Z
Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism.
1. Cell Rep - published July 1, 2021
2. Singh CR, Glineburg MR, Moore C, Tani N, Jaiswal R, Zou Y, Aube E, Gillaspie S, Thornton M, Cecil A, Hilgers M, Takasu A, Asano I, Asano M, Escalante CR, Nakamura A, Todd PK, Asano K
Aboard the ISS: intersubunit signaling revealed in the p97 ATPase.
1. Nat Struct Mol Biol - published July 1, 2021
2. Twomey EC
cGAS-like receptors sense RNA and control 3'2'-cGAMP signaling in Drosophila.
1. Nature - published July 1, 2021
2. Slavik KM, Morehouse BR, Ragucci AE, Zhou W, Ai X, Chen Y, Li L, Wei Z, Bähre H, König M, Seifert R, Lee ASY, Cai H, Imler JL, Kranzusch PJ
Mechanistic insight into substrate processing and allosteric inhibition of human p97.
1. Nat Struct Mol Biol - published July 1, 2021
2. Pan M, Yu Y, Ai H, Zheng Q, Xie Y, Liu L, Zhao M
Ebola vaccine-induced protection in nonhuman primates correlates with antibody specificity and Fc-mediated effects.
1. Sci Transl Med - published July 1, 2021
2. Meyer M, Gunn BM, Malherbe DC, Gangavarapu K, Yoshida A, Pietzsch C, Kuzmina NA, Saphire EO, Collins PL, Crowe JE Jr, Zhu JJ, Suchard MA, Brining DL, Mire CE, Cross RW, Geisbert JB, Samal SK, Andersen KG, Alter G, Geisbert TW, Bukreyev A
Non-canonical proline-tyrosine interactions with multiple host proteins regulate Ebola virus infection.
1. EMBO J - published July 1, 2021
2. Batra J, Mori H, Small GI, Anantpadma M, Shtanko O, Mishra N, Zhang M, Liu D, Williams CG, Biedenkopf N, Becker S, Gross ML, Leung DW, Davey RA, Amarasinghe GK, Krogan NJ, Basler CF
Cryo-EM structures of the caspase activated protein XKR9 involved in apoptotic lipid scrambling.
1. Elife - published July 1, 2021
2. Straub MS, Alvadia C, Sawicka M, Dutzler R
Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle.
1. Cell Rep - published July 1, 2021
2. Jomaa A, Eitzinger S, Zhu Z, Chandrasekar S, Kobayashi K, Shan SO, Ban N
Recognition of N6-Methyladenosine by the YTHDC1 YTH Domain Studied by Molecular Dynamics and NMR Spectroscopy: The Role of Hydration.
1. J Phys Chem B - published July 1, 2021
2. Krepl M, Damberger FF, von Schroetter C, Theler D, Pokorná P, Allain FH, Šponer J
Role of sequence and position of the cleavage sites in prothrombin activation.
1. J Biol Chem - published July 1, 2021
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Molecular basis for ligand modulation of the cannabinoid receptor CB1.
1. Br J Pharmacol - published July 1, 2021
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Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses.
1. Nat Commun - published July 1, 2021
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SnapShot: SARS-CoV-2 antibodies.
1. Cell Host Microbe - published July 1, 2021
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An intranasal vaccine durably protects against SARS-CoV-2 variants in mice.
1. Cell Rep - published July 1, 2021
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Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo.
1. Nucleic Acids Res - published July 1, 2021
2. Jahns H, Taneja N, Willoughby JLS, Akabane-Nakata M, Brown CR, Nguyen T, Bisbe A, Matsuda S, Hettinger M, Manoharan RM, Rajeev KG, Maier MA, Zlatev I, Charisse K, Egli M, Manoharan M
Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex.
1. Nat Commun - published July 1, 2021
2. Huang X, Hu H, Webster A, Zou F, Du J, Patel DJ, Sachidanandam R, Toth KF, Aravin AA, Li S
DeepEMhancer: a deep learning solution for cryo-EM volume post-processing.
1. Commun Biol - published July 1, 2021
2. Sanchez-Garcia R, Gomez-Blanco J, Cuervo A, Carazo JM, Sorzano COS, Vargas J
PAIREF: paired refinement also for Phenix users.
1. Acta Crystallogr F Struct Biol Commun - published July 1, 2021
2. Malý M, Diederichs K, Dohnálek J, Kolenko P
Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies.
1. Nat Commun - published July 1, 2021
2. De Groof TWM, Bergkamp ND, Heukers R, Giap T, Bebelman MP, Goeij-de Haas R, Piersma SR, Jimenez CR, Garcia KC, Ploegh HL, Siderius M, Smit MJ
Structural details of monoclonal antibody m971 recognition of the membrane-proximal domain of CD22.
1. J Biol Chem - published July 1, 2021
2. Ereño-Orbea J, Liu X, Sicard T, Kucharska I, Li W, Borovsky D, Cui H, Feng Y, Dimitrov DS, Julien JP
Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
1. Nat Commun - published July 1, 2021
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