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129 Member Publications for July

Previous Month

Children's rare disease cohorts: an integrative research and clinical genomics initiative.
1. NPJ Genom Med - published July 14, 2020
2. Rockowitz S, LeCompte N, Carmack M, Quitadamo A, Wang L, Park M, Knight D, Sexton E, Smith L, Sheidley B, Field M, Holm IA, Brownstein CA, Agrawal PB, Kornetsky S, Poduri A, Snapper SB, Beggs AH, Yu TW, Williams DA, Sliz P
Malignant tissues produce divergent antibody glycosylation of relevance for cancer gene therapy effectiveness.
1. MAbs - published July 9, 2020
2. Brücher D, Franc V, Smith SN, Heck AJR, Plückthun A
Escherichia coli NusG Links the Lead Ribosome with the Transcription Elongation Complex.
1. iScience - published July 9, 2020
2. Washburn RS, Zuber PK, Sun M, Hashem Y, Shen B, Li W, Harvey S, Acosta Reyes FJ, Gottesman ME, Knauer SH, Frank J
Direct Relationship Between Increased Expression and Mistrafficking of the Charcot-Marie-Tooth-Associated Protein PMP22.
1. J Biol Chem - published July 9, 2020
2. Marinko JT, Carter BD, Sanders CR
Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor.
1. ACS Med Chem Lett - published July 9, 2020
2. Mpakali A, Saridakis E, Giastas P, Maben Z, Stern LJ, Larhed M, Hallberg M, Stratikos E
The Structural Basis for Kinetochore Stabilization by Cnn1/CENP-T.
1. Curr Biol - published July 9, 2020
2. Hinshaw SM, Harrison SC
Need for Speed: From Human SARS-CoV-2 Samples to Protective and Efficacious Antibodies in Weeks.
1. Cell - published July 9, 2020
2. Joyce MG, Wheatley AK, Modjarrad K
The N-terminal domain of Staphylothermus marinus McrB shares structural homology with PUA-like RNA binding proteins.
1. J Struct Biol - published July 8, 2020
2. Hosford CJ, Adams MC, Niu Y, Chappie JS
The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain.
1. Structure - published July 8, 2020
2. Jung T, Shin B, Tamo G, Kim H, Vijayvargia R, Leitner A, Marcaida MJ, Astorga-Wells J, Jung R, Aebersold R, Peraro MD, Hebert H, Seong IS, Song JJ
Diverse patterns of antibody variable gene repertoire disruption in patients with amyloid light chain (AL) amyloidosis.
1. PLoS One - published July 8, 2020
2. Chen EC, Rubinstein S, Soto C, Bombardi RG, Day SB, Myers L, Zaytsev A, Majedi M, Cornell RF, Crowe JE Jr
Protein crystals as a key for deciphering macromolecular crowding effects on biological reactions.
1. Phys Chem Chem Phys - published July 8, 2020
2. Ferreira C, Pinto MF, Macedo-Ribeiro S, Pereira PJB, Rocha FA, Martins PM
Structural Investigation of 2-Naphthyl Phenyl Ether Inhibitors Bound to WT and Y181C Reverse Transcriptase Highlights Key Features of the NNRTI Binding Site.
1. Protein Sci - published July 8, 2020
2. Duong VN, Ippolito JA, Chan AH, Lee WG, Spasov KA, Jorgensen WL, Anderson KS
Group 2 Innate Lymphoid Cells Must Partner with the Myeloid-Macrophage Lineage for Long-Term Postviral Lung Disease.
1. J Immunol - published July 8, 2020
2. Wu K, Wang X, Keeler SP, Gerovac BJ, Agapov EV, Byers DE, Gilfillan S, Colonna M, Zhang Y, Holtzman MJ
Irritant-evoked activation and calcium modulation of the TRPA1 receptor.
1. Nature - published July 8, 2020
2. Zhao J, Lin King JV, Paulsen CE, Cheng Y, Julius D
L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins.
1. Proc Natl Acad Sci U S A - published July 8, 2020
2. Johnson MT, Gudlur A, Zhang X, Xin P, Emrich SM, Yoast RE, Courjaret R, Nwokonko RM, Li W, Hempel N, Machaca K, Gill DL, Hogan PG, Trebak M
Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner.
1. Cell Rep - published July 7, 2020
2. Gray S, Santiago ER, Chappie JS, Cohen PE
Prevalence and pathogenicity of autoantibodies in patients with idiopathic CD4 lymphopenia.
1. J Clin Invest - published July 7, 2020
2. Perez-Diez A, Wong CS, Liu X, Mystakelis HA, Song J, Lu Y, Sheikh V, Bourgeois JS, Lisco A, Laidlaw E, Cudrici CD, Zhu C, Li QZ, Freeman AF, Williamson PR, Anderson MV, Roby G, Tsang JS, Siegel RM, Sereti I
CcpNmr AnalysisScreen, a new software programme with dedicated automated analysis tools for fragment-based drug discovery by NMR.
1. J Biomol NMR - published July 7, 2020
2. Mureddu LG, Ragan TJ, Brooksbank EJ, Vuister GW
When Less Is More: Combining Site-Specific Isotope Labeling and NMR Unravels Structural Details of Huntingtin Repeats.
1. Structure - published July 7, 2020
2. Delhommel F, Sattler M
ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer.
1. J Cell Biol - published July 6, 2020
2. Shi X, Yokom AL, Wang C, Young LN, Youle RJ, Hurley JH
DiB-splits: nature-guided design of a novel fluorescent labeling split system.
1. Sci Rep - published July 6, 2020
2. Bozhanova NG, Gavrikov AS, Mishin AS, Meiler J
A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy.
1. J Cell Biol - published July 6, 2020
2. Fracchiolla D, Chang C, Hurley JH, Martens S
Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex.
1. Proc Natl Acad Sci U S A - published July 6, 2020
2. Bhargava HK, Tabata K, Byck JM, Hamasaki M, Farrell DP, Anishchenko I, DiMaio F, Im YJ, Yoshimori T, Hurley JH
A partially disordered region connects gene repression and activation functions of EZH2.
1. Proc Natl Acad Sci U S A - published July 6, 2020
2. Jiao L, Shubbar M, Yang X, Zhang Q, Chen S, Wu Q, Chen Z, Rizo J, Liu X
Role of the activation peptide in the mechanism of protein C activation.
1. Sci Rep - published July 6, 2020
2. Stojanovski BM, Pelc LA, Di Cera E
Trnp1 organizes diverse nuclear membrane-less compartments in neural stem cells.
1. EMBO J - published July 6, 2020
2. Esgleas M, Falk S, Forné I, Thiry M, Najas S, Zhang S, Mas-Sanchez A, Geerlof A, Niessing D, Wang Z, Imhof A, Götz M
The Tubulin Code in Microtubule Dynamics and Information Encoding.
1. Dev Cell - published July 6, 2020
2. Roll-Mecak A
Local resolution estimates of cryoEM reconstructions.
1. Curr Opin Struct Biol - published July 6, 2020
2. Vilas JL, Heymann JB, Tagare HD, Ramirez-Aportela E, Carazo JM, Sorzano C
Sex Differences in the Repair of Retinal Detachments in the United States.
1. Am J Ophthalmol - published July 5, 2020
2. Callaway NF, Vail D, Al-Moujahed A, Ludwig C, Ji MH, Mahajan VB, Pershing S, Moshfeghi DM
Anti-MUC1-C Antibody-conjugated Nanoparticles Potentiate the Efficacy of Fractionated Radiation Therapy.
1. Int J Radiat Oncol Biol Phys - published July 4, 2020
2. A D, C M, C J, M A, Mc D, Vl T, X P, F L, O T, D K, Pp G
Mechanisms of PI(4,5)P2 enrichment in HIV-1 viral membranes.
1. J Mol Biol - published July 3, 2020
2. Wen Y, Feigenson GW, Vogt VM, Dick RA
MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma.
1. J Hepatol - published July 3, 2020
2. Komoll RM, Hu Q, Olarewaju O, von Döhlen L, Yuan Q, Xie Y, Tsay HC, Daon J, Qin R, Manns MP, Sharma AD, Goga A, Ott M, Balakrishnan A
ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
1. Science - published July 3, 2020
2. Pinto PH, Kroupova A, Schleiffer A, Mechtler K, Jinek M, Weitzer S, Martinez J
Structural insights into differences in G protein activation by family A and family B GPCRs.
1. Science - published July 3, 2020
2. Hilger D, Kumar KK, Hu H, Pedersen MF, O'Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK
Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2.
1. Cell Host Microbe - published July 3, 2020
2. Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, Ustav M, Sidhu S, Virgin HW, Wang D, Ding S, Corti D, Theel ES, Fremont DH, Diamond MS, Whelan SPJ
Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques.
1. Nature - published July 3, 2020
2. Mercado NB, Zahn R, Wegmann F, Loos C, Chandrashekar A, Yu J, Liu J, Peter L, McMahan K, Tostanoski LH, He X, Martinez DR, Rutten L, Bos R, van Manen D, Vellinga J, Custers J, Langedijk JP, Kwaks T, Bakkers MJG, Zuijdgeest D, Huber SKR, Atyeo C, Fischinger S, Burke JS, Feldman J, Hauser BM, Caradonna TM, Bondzie EA, Dagotto G, Gebre MS, Hoffman E, Jacob-Dolan C, Kirilova M, Li Z, Lin Z, Mahrokhian SH, Maxfield LF, Nampanya F, Nityanandam R, Nkolola JP, Patel S, Ventura JD, Verrington K, Wan H, Pessaint L, Ry AV, Blade K, Strasbaugh A, Cabus M, Brown R, Cook A, Zouantchangadou S, Teow E, Andersen H, Lewis MG, Cai Y, Chen B, Schmidt AG, Reeves RK, Baric RS, Lauffenburger DA, Alter G, Stoffels P, Mammen M, Hoof JV, Schuitemaker H, Barouch DH
Molecular Mechanisms in Integral Membrane Enzymology.
1. J Mol Biol - published July 3, 2020
2. Li W, Bishop RE, Mancia F
Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease.
1. Sci Immunol - published July 3, 2020
2. Vogt MR, Fu J, Kose N, Williamson LE, Bombardi R, Setliff I, Georgiev IS, Klose T, Rossmann MG, Bochkov YA, Gern JE, Kuhn RJ, Crowe JE Jr
Probabilistic identification of saccharide moieties in biomolecules and their protein complexes.
1. Sci Data - published July 3, 2020
2. Dashti H, Westler WM, Wedell JR, Demler OV, Eghbalnia HR, Markley JL, Mora S
Structural insight into mitochondrial β-barrel outer membrane protein biogenesis.
1. Nat Commun - published July 3, 2020
2. Diederichs KA, Ni X, Rollauer SE, Botos I, Tan X, King MS, Kunji ERS, Jiang J, Buchanan SK
Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol.
1. Commun Biol - published July 3, 2020
2. Chabloz A, Schaefer JV, Kozieradzki I, Cronin SJF, Strebinger D, Macaluso F, Wald J, Rabbitts TH, Plückthun A, Marlovits TC, Penninger JM
Protein nanoribbons template enamel mineralization.
1. Proc Natl Acad Sci U S A - published July 3, 2020
2. Bai Y, Yu Z, Ackerman L, Zhang Y, Bonde J, Li W, Cheng Y, Habelitz S
Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine.
1. Nat Commun - published July 2, 2020
2. Lara J, Diacovich L, Trajtenberg F, Larrieux N, Malchiodi EL, Fernández MM, Gago G, Gramajo H, Buschiazzo A
Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes.
1. Cell Stem Cell - published July 2, 2020
2. Buikema JW, Lee S, Goodyer WR, Maas RG, Chirikian O, Li G, Miao Y, Paige SL, Lee D, Wu H, Paik DT, Rhee S, Tian L, Galdos FX, Puluca N, Beyersdorf B, Hu J, Beck A, Venkamatran S, Swami S, Wijnker P, Schuldt M, Dorsch LM, van Mil A, Red-Horse K, Wu JY, Geisen C, Hesse M, Serpooshan V, Jovinge S, Fleischmann BK, Doevendans PA, van der Velden J, Garcia KC, Wu JC, Sluijter JPG, Wu SM
An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth.
1. Proc Natl Acad Sci U S A - published July 2, 2020
2. Vidimar V, Beilhartz GL, Park M, Biancucci M, Kieffer MB, Gius DR, Melnyk RA, Satchell KJF
Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation.
1. Proc Natl Acad Sci U S A - published July 2, 2020
2. Chan DTY, Jenkinson L, Haynes SW, Austin M, Diamandakis A, Burschowsky D, Seewooruthun C, Addyman A, Fiedler S, Ryman S, Whitehouse J, Slater LH, Gowans E, Shibata Y, Barnard M, Wilkinson RW, Vaughan TJ, Holt SV, Cerundolo V, Carr MD, Groves MAT
TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate.
1. Cell - published July 2, 2020
2. Venturutti L, Teater M, Zhai A, Chadburn A, Babiker L, Kim D, Béguelin W, Lee TC, Kim Y, Chin CR, Yewdell WT, Raught B, Phillip JM, Jiang Y, Staudt LM, Green MR, Chaudhuri J, Elemento O, Farinha P, Weng AP, Nissen MD, Steidl C, Morin RD, Scott DW, Privé GG, Melnick AM
Conformational Basis of G Protein-Coupled Receptor Signaling Versatility.
1. Trends Cell Biol - published July 2, 2020
2. Wingler LM, Lefkowitz RJ
Identification of Nonradiative Decay Pathways in Cy3.
1. J Phys Chem Lett - published July 2, 2020
2. Hart SM, Banal JL, Bathe M, Schlau-Cohen GS
Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation.
1. Sci Signal - published July 2, 2020
2. Sloutsky R, Dziedzic N, Dunn MJ, Bates RM, Torres-Ocampo AP, Boopathy S, Page B, Weeks JG, Chao LH, Stratton MM
Long-range intramolecular allostery and regulation in the dynein-like AAA protein Mdn1.
1. Proc Natl Acad Sci U S A - published July 2, 2020
2. Mickolajczyk KJ, Olinares PDB, Niu Y, Chen N, Warrington SE, Sasaki Y, Walz T, Chait BT, Kapoor TM
Potent neutralizing antibodies directed to multiple epitopes on SARS-CoV-2 spike.
1. Nature - published July 2, 2020
2. Liu L, Wang P, Nair MS, Yu J, Rapp M, Wang Q, Luo Y, Chan JF, Sahi V, Figueroa A, Guo XV, Cerutti G, Bimela J, Gorman J, Zhou T, Chen Z, Yuen KY, Kwong PD, Sodroski JG, Yin MT, Sheng Z, Huang Y, Shapiro L, Ho DD
Distinct conformational states of SARS-CoV-2 spike protein.
1. Science - published July 2, 2020
2. Cai Y, Zhang J, Xiao T, Peng H, Sterling SM, Walsh RM Jr, Rawson S, Rits-Volloch S, Chen B
Electron tomography visualization of HIV-1 fusion with target cells using inhibitors to trap the prehairpin intermediate.
1. Elife - published July 2, 2020
2. Ladinsky MS, Gnanapragasam PNP, Yang Z, West AP, Kay MS, Bjorkman PJ
Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.
1. Cell Rep - published July 2, 2020
2. Koirala S, Klein J, Zheng Y, Glenn NO, Eisemann T, Fon Tacer K, Miller DJ, Kulak O, Lu M, Finkelstein DB, Neale G, Tillman H, Vogel P, Strand DW, Lum L, Brautigam CA, Pascal JM, Clements WK, Potts PR
Controlling the SARS-CoV-2 spike glycoprotein conformation.
1. Nat Struct Mol Biol - published July 2, 2020
2. Henderson R, Edwards RJ, Mansouri K, Janowska K, Stalls V, Gobeil SMC, Kopp M, Li D, Parks R, Hsu AL, Borgnia MJ, Haynes BF, Acharya P
Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A.
1. Nat Commun - published July 2, 2020
2. Camacho-Zarco AR, Kalayil S, Maurin D, Salvi N, Delaforge E, Milles S, Jensen MR, Hart DJ, Cusack S, Blackledge M
Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.
1. Cell Rep - published July 2, 2020
2. Yan W, Markegard E, Dharmaiah S, Urisman A, Drew M, Esposito D, Scheffzek K, Nissley DV, McCormick F, Simanshu DK
Cryo-electron microscopy of the chromatin fiber.
1. Curr Opin Struct Biol - published July 2, 2020
2. Boopathi R, Dimitrov S, Hamiche A, Petosa C, Bednar J
Opportunities, Barriers, and a Strategy for Overcoming Translational Challenges to Therapeutic Nucleic Acid Nanotechnology.
1. ACS Nano - published July 2, 2020
2. Afonin KA, Dobrovolskaia MA, Church G, Bathe M
Whole-Exome Sequencing of Patients with Posterior Segment Uveitis.
1. Am J Ophthalmol - published July 2, 2020
2. Li AS, Velez G, Darbro B, Toral MA, Yang J, Tsang SH, Ferguson PJ, Folk JC, Bassuk AG, Mahajan VB
Highly Conserved Molecular Features in IgLONs Contrast their Distinct Structural and Biological Outcomes.
1. J Mol Biol - published July 2, 2020
2. Venkannagari H, Kasper JM, Misra A, Rush SA, Fan S, Lee H, Sun H, Seshadrinathan S, Machius M, Hommel JD, Rudenko G
Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity.
1. Elife - published July 2, 2020
2. Mendoza JL, Fischer S, Gee MH, Lam LH, Brackenridge S, Powrie FM, Birnbaum M, McMichael AJ, Garcia KC, Gillespie GM
Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance.
1. Nat Commun - published July 2, 2020
2. Deng Z, Maksaev G, Schlegel AM, Zhang J, Rau M, Fitzpatrick JAJ, Haswell ES, Yuan P
A structural framework for unidirectional transport by a bacterial ABC exporter.
1. Proc Natl Acad Sci U S A - published July 2, 2020
2. Fan C, Kaiser JT, Rees DC
The crystal structures of a chloride-pumping microbial rhodopsin and its proton-pumping mutant illuminate proton transfer determinants.
1. J Biol Chem - published July 2, 2020
2. Besaw JE, Ou WL, Morizumi T, Eger BT, Sanchez Vasquez JD, Chu JHY, Harris A, Brown LS, Miller RJD, Ernst OP
Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED.
1. Structure - published July 2, 2020
2. Zhu L, Bu G, Jing L, Shi D, Lee MY, Gonen T, Liu W, Nannenga BL
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes.
1. Science - published July 2, 2020
2. Hsieh CL, Goldsmith JA, Schaub JM, DiVenere AM, Kuo HC, Javanmardi K, Le KC, Wrapp D, Lee AG, Liu Y, Chou CW, Byrne PO, Hjorth CK, Johnson NV, Ludes-Meyers J, Nguyen AW, Park J, Wang N, Amengor D, Lavinder JJ, Ippolito GC, Maynard JA, Finkelstein IJ, McLellan JS
Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd.
1. Nat Commun - published July 2, 2020
2. Brugger C, Zhang C, Suhanovsky MM, Kim DD, Sinclair AN, Lyumkis D, Deaconescu AM
Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes.
1. Nat Metab - published July 2, 2020
2. Cai EP, Ishikawa Y, Zhang W, Leite NC, Li J, Hou S, Kiaf B, Hollister-Lock J, Yilmaz NK, Schiffer CA, Melton DA, Kissler S, Yi P
The role of NMR in leveraging dynamics and entropy in drug design.
1. J Biomol NMR - published July 2, 2020
2. Dubey A, Takeuchi K, Reibarkh M, Arthanari H
Animal-derived-antibody generation faces strict reform in accordance with European Union policy on animal use.
1. Nat Methods - published July 2, 2020
2. Gray AC, Bradbury ARM, Knappik A, Plückthun A, Borrebaeck CAK, Dübel S
XMAP215 and γ-tubulin additively promote microtubule nucleation in purified solutions.
1. Mol Biol Cell - published July 2, 2020
2. King BR, Moritz M, Kim H, Agard DA, Asbury CL, Davis TN
Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.
1. Nucleic Acids Res - published July 2, 2020
2. Lemeille S, Paschaki M, Baas D, Morlé L, Duteyrat JL, Ait-Lounis A, Barras E, Soulavie F, Jerber J, Thomas J, Zhang Y, Holtzman MJ, Kistler WS, Reith W, Durand B
Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel.
1. J Biol Chem - published July 2, 2020
2. Burton MJ, Cresser-Brown J, Thomas M, Portolano N, Basran J, Freeman SL, Kwon H, Bottrill AR, Llansola-Portoles MJ, Pascal AA, Jukes-Jones R, Chernova T, Schmid R, Davies NW, Storey NM, Dorlet P, Moody PCE, Mitcheson JS, Raven EL
Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates.
1. N Engl J Med - published July 2, 2020
2. Corbett KS, Flynn B, Foulds KE, Francica JR, Boyoglu-Barnum S, Werner AP, Flach B, O'Connell S, Bock KW, Minai M, Nagata BM, Andersen H, Martinez DR, Noe AT, Douek N, Donaldson MM, Nji NN, Alvarado GS, Edwards DK, Flebbe DR, Lamb E, Doria-Rose NA, Lin BC, Louder MK, O'Dell S, Schmidt SD, Phung E, Chang LA, Yap C, Todd JM, Pessaint L, Van Ry A, Browne S, Greenhouse J, Putman-Taylor T, Strasbaugh A, Campbell TA, Cook A, Dodson A, Steingrebe K, Shi W, Zhang Y, Abiona OM, Wang L, Pegu A, Yang ES, Leung K, Zhou T, Teng IT, Widge A, Gordon I, Novik L, Gillespie RA, Loomis RJ, Moliva JI, Stewart-Jones G, Himansu S, Kong WP, Nason MC, Morabito KM, Ruckwardt TJ, Ledgerwood JE, Gaudinski MR, Kwong PD, Mascola JR, Carfi A, Lewis MG, Baric RS, McDermott A, Moore IN, Sullivan NJ, Roederer M, Seder RA, Graham BS
Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy.
1. ACS Cent Sci - published July 2, 2020
2. Beveridge R, Kessler D, Rumpel K, Ettmayer P, Meinhart A, Clausen T
Author Correction: Structural insights into μ-opioid receptor activation.
1. Nature - published July 2, 2020
2. Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK
GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.
1. Mol Cell - published July 2, 2020
2. Hickey KL, Dickson K, Cogan JZ, Replogle JM, Schoof M, D'Orazio KN, Sinha NK, Hussmann JA, Jost M, Frost A, Green R, Weissman JS, Kostova KK
Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations.
1. Elife - published July 2, 2020
2. Xue J, Xie T, Zeng W, Jiang Y, Bai XC
RORγ Structural Plasticity and Druggability.
1. Int J Mol Sci - published July 2, 2020
2. Huang M, Bolin S, Miller H, Ng HL
Structural interpretation of cryo-EM image reconstructions.
1. Prog Biophys Mol Biol - published July 2, 2020
2. Beckers M, Mann D, Sachse C
Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor.
1. bioRxiv - published July 2, 2020
2. Zhao P, Praissman JL, Grant OC, Cai Y, Xiao T, Rosenbalm KE, Aoki K, Kellman BP, Bridger R, Barouch DH, Brindley MA, Lewis NE, Tiemeyer M, Chen B, Woods RJ, Wells L
3D Printed frames to enable reuse and improve the fit of N95 and KN95 respirators.
1. medRxiv - published July 2, 2020
2. McAvoy M, Bui AN, Hansen C, Plana D, Said JT, Yu Z, Yang H, Freake J, Van C, Krikorian D, Cramer A, Smith L, Jiang L, Lee KJ, Li SJ, Beller B, Short M, Yu SH, Mostaghimi A, Sorger PK, LeBoeuf NR
Dynamics and significance of the antibody response to SARS-CoV-2 infection.
1. medRxiv - published July 2, 2020
2. Iyer AS, Jones FK, Nodoushani A, Kelly M, Becker M, Slater D, Mills R, Teng E, Kamruzzaman M, Garcia-Beltran WF, Astudillo M, Yang D, Miller TE, Oliver E, Fischinger S, Atyeo C, Iafrate AJ, Calderwood SB, Lauer SA, Yu J, Li Z, Feldman J, Hauser BM, Caradonna TM, Branda JA, Turbett SE, LaRocque RC, Mellon G, Barouch DH, Schmidt AG, Azman AS, Alter G, Ryan ET, Harris JB, Charles RC
The Solvent-Exposed Fe-S D-Cluster Contributes to Oxygen-Resistance in Desulfovibrio vulgaris Ni-Fe Carbon Monoxide Dehydrogenase.
1. ACS Catal - published July 2, 2020
2. Wittenborn EC, Guendon C, Merrouch M, Benvenuti M, Fourmond V, Léger C, Drennan CL, Dementin S
Challenging a Preconception: Optoacoustic Spectrum Differs from the Optical Absorption Spectrum of Proteins and Dyes for Molecular Imaging.
1. Anal Chem - published July 2, 2020
2. Fuenzalida Werner JP, Huang Y, Mishra K, Janowski R, Vetschera P, Heichler C, Chmyrov A, Neufert C, Niessing D, Ntziachristos V, Stiel AC
Nanoparticles presenting clusters of CD4 expose a universal vulnerability of HIV-1 by mimicking target cells.
1. Proc Natl Acad Sci U S A - published July 2, 2020
2. Hoffmann MAG, Bar-On Y, Yang Z, Gristick HB, Gnanapragasam PNP, Vielmetter J, Nussenzweig MC, Bjorkman PJ
From Input to Output: The Lap/c-di-GMP Biofilm Regulatory Circuit.
1. Annu Rev Microbiol - published July 2, 2020
2. Collins AJ, Smith TJ, Sondermann H, O'Toole GA
Diffusible signal factors act through AraC-type transcriptional regulators as chemical cues to repress virulence of enteric pathogens.
1. Infect Immun - published July 2, 2020
2. Bosire EM, Eade CR, Schiltz CJ, Reid AJ, Troutman J, Chappie JS, Altier C
The Clinically Approved Antifungal Drug Posaconazole Inhibits Human Cytomegalovirus Replication.
1. Antimicrob Agents Chemother - published July 2, 2020
2. Mercorelli B, Luganini A, Celegato M, Palù G, Gribaudo G, Lepesheva GI, Loregian A
Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association.
1. Nat Microbiol - published July 2, 2020
2. Rabouw HH, Visser LJ, Passchier TC, Langereis MA, Liu F, Giansanti P, van Vliet ALW, Dekker JG, van der Grein SG, Saucedo JG, Anand AA, Trellet ME, Bonvin AMJJ, Walter P, Heck AJR, de Groot RJ, van Kuppeveld FJM
AMPA Receptor Auxiliary Subunit GSG1L Suppresses Short-Term Facilitation in Corticothalamic Synapses and Determines Seizure Susceptibility.
1. Cell Rep - published July 2, 2020
2. Kamalova A, Futai K, Delpire E, Nakagawa T
Dominant role of αIIbβ3 in platelet interactions with cross-linked fibrin fragment D-dimer.
1. Blood Adv - published July 1, 2020
2. Buitrago L, Zafar H, Zhang Y, Li J, Walz T, Coller BS
The Loss of Bcl-6 Expressing T Follicular Helper Cells and the Absence of Germinal Centers in COVID-19.
1. SSRN - published July 1, 2020
2. Kaneko N, Kuo HH, Boucau J, Farmer JR, Allard-Chamard H, Mahajan VS, Piechocka-Trocha A, Lefteri K, Osborn M, Bals J, Bartsch YC, Bonheur N, Caradonna TM, Chevalier J, Chowdhury F, Diefenbach TJ, Einkauf K, Fallon J, Feldman J, Finn KK, Garcia-Broncano P, Hartana CA, Hauser BM, Jiang C, Kaplonek P, Karpell M, Koscher EC, Lian X, Liu H, Liu J, Ly NL, Michell AR, Rassadkina Y, Seiger K, Sessa L, Shin S, Singh N, Sun W, Sun X, Ticheli HJ, Waring MT, Zhu AL, Li J, Lingwood D, Schmidt AG, Lichterfeld M, Walker BD, Yu X, Padera RF, Pillai S, Group MCOPRSW
Identifying Structural Determinants of Product Specificity in Leishmania major Farnesyl Diphosphate Synthase.
1. Biochemistry - published July 1, 2020
2. Maheshwari S, Kim YS, Aripirala S, Murphy M, Amzel LM, Gabelli SB
MDM2 inhibition: an important step forward in cancer therapy.
1. Leukemia - published July 1, 2020
2. Konopleva M, Martinelli G, Daver N, Papayannidis C, Wei A, Higgins B, Ott M, Mascarenhas J, Andreeff M
Author Correction: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.
1. Nat Med - published July 1, 2020
2. Menachery VD, Yount BL Jr, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS
Author Correction: Structure of human GABAB receptor in an inactive state.
1. Nature - published July 1, 2020
2. Park J, Fu Z, Frangaj A, Liu J, Mosyak L, Shen T, Slavkovich VN, Ray KM, Taura J, Cao B, Geng Y, Zuo H, Kou Y, Grassucci R, Chen S, Liu Z, Lin X, Williams JP, Rice WJ, Eng ET, Huang RK, Soni RK, Kloss B, Yu Z, Javitch JA, Hendrickson WA, Slesinger PA, Quick M, Graziano J, Yu H, Fiehn O, Clarke OB, Frank J, Fan QR
Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans.
1. Proc Natl Acad Sci U S A - published July 1, 2020
2. Ellebedy AH, Nachbagauer R, Jackson KJL, Dai YN, Han J, Alsoussi WB, Davis CW, Stadlbauer D, Rouphael N, Chromikova V, McCausland M, Chang CY, Cortese M, Bower M, Chennareddy C, Schmitz AJ, Zarnitsyna VI, Lai L, Rajabhathor A, Kazemian C, Antia R, Mulligan MJ, Ward AB, Fremont DH, Boyd SD, Pulendran B, Krammer F, Ahmed R
Potently neutralizing and protective human antibodies against SARS-CoV-2.
1. Nature - published July 1, 2020
2. Zost SJ, Gilchuk P, Case JB, Binshtein E, Chen RE, Nkolola JP, Schäfer A, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Martinez DR, Williamson LE, Chen EC, Jones T, Day S, Myers L, Hassan AO, Kafai NM, Winkler ES, Fox JM, Shrihari S, Mueller BK, Meiler J, Chandrashekar A, Mercado NB, Steinhardt JJ, Ren K, Loo YM, Kallewaard NL, McCune BT, Keeler SP, Holtzman MJ, Barouch DH, Gralinski LE, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe JE Jr
Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2.
1. Elife - published July 1, 2020
2. Wang C, Jacewicz A, Delgado BD, Baradaran R, Long SB
High Frequency of Shared Clonotypes in Human T Cell Receptor Repertoires.
1. Cell Rep - published July 1, 2020
2. Soto C, Bombardi RG, Kozhevnikov M, Sinkovits RS, Chen EC, Branchizio A, Kose N, Day SB, Pilkinton M, Gujral M, Mallal S, Crowe JE Jr
Histone acetyl transferase MOF orchestrates outcomes at the crossroad of oncogenesis, DNA damage response, proliferation, and stem cell development.
1. Mol Cell Biol - published July 1, 2020
2. Singh M, Bacolla A, Chaudhary S, Hunt CR, Pandita S, Chauhan R, Gupta A, Tainer JA, Pandita TK
A redox switch regulates the structure and function of anti-apoptotic BFL-1.
1. Nat Struct Mol Biol - published July 1, 2020
2. Korshavn KJ, Wales TE, Bird GH, Engen JR, Walensky LD
Structure-based development of a subtype-selective orexin 1 receptor antagonist.
1. Proc Natl Acad Sci U S A - published July 1, 2020
2. Hellmann J, Drabek M, Yin J, Gunera J, Pröll T, Kraus F, Langmead CJ, Hübner H, Weikert D, Kolb P, Rosenbaum DM, Gmeiner P
Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis.
1. Mol Cell - published July 1, 2020
2. Jaskolowski M, Ramrath DJF, Bieri P, Niemann M, Mattei S, Calderaro S, Leibundgut M, Horn EK, Boehringer D, Schneider A, Ban N
Modular microfluidics enables kinetic insight from time-resolved cryo-EM.
1. Nat Commun - published July 1, 2020
2. Mäeots ME, Lee B, Nans A, Jeong SG, Esfahani MMN, Ding S, Smith DJ, Lee CS, Lee SS, Peter M, Enchev RI
Opportunities and challenges for the clinical translation of structured DNA assemblies as gene therapeutic delivery and vaccine vectors.
1. Wiley Interdiscip Rev Nanomed Nanobiotechnol - published July 1, 2020
2. Dobrovolskaia MA, Bathe M
Humoral Immunity to Hantavirus Infection.
1. mSphere - published July 1, 2020
2. Engdahl TB, Crowe JE Jr
PyIR: a scalable wrapper for processing billions of immunoglobulin and T cell receptor sequences using IgBLAST.
1. BMC Bioinformatics - published July 1, 2020
2. Soto C, Finn JA, Willis JR, Day SB, Sinkovits RS, Jones T, Schmitz S, Meiler J, Branchizio A, Crowe JE Jr
RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling.
1. J Biol Chem - published July 1, 2020
2. Nelson AC, Turbyville TJ, Dharmaiah S, Rigby M, Yang R, Wang TY, Columbus J, Stephens R, Taylor T, Sciacca D, Onsongo G, Sarver A, Subramanian S, Nissley DV, Simanshu DK, Lou E
Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.
1. Nat Commun - published July 1, 2020
2. Arragain B, Effantin G, Gerlach P, Reguera J, Schoehn G, Cusack S, Malet H
Structure and selectivity engineering of the M1 muscarinic receptor toxin complex.
1. Science - published July 1, 2020
2. Maeda S, Xu J, N Kadji FM, Clark MJ, Zhao J, Tsutsumi N, Aoki J, Sunahara RK, Inoue A, Garcia KC, Kobilka BK
Methyltransferase contingencies in the pathway of everninomicin D antibiotics and analogs.
1. Chembiochem - published July 1, 2020
2. Limbrick EM, Ynigez-Gutierrez AE, Dulin CC, Derewacz DK, Spraggins JM, McCulloch KM, Iverson TM, Bachmann BO
The precious fluorine on the ring: fluorine NMR for biological systems.
1. J Biomol NMR - published July 1, 2020
2. Boeszoermenyi A, Ogórek B, Jain A, Arthanari H, Wagner G
Permutation testing of Fourier shell correlation for resolution estimation of cryo-EM maps.
1. J Struct Biol - published July 1, 2020
2. Beckers M, Sachse C
Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein.
1. Nat Med - published July 1, 2020
2. Zost SJ, Gilchuk P, Chen RE, Case JB, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Chen EC, Binshtein E, Shrihari S, Ostrowski M, Chu HY, Didier JE, MacRenaris KW, Jones T, Day S, Myers L, Eun-Hyung Lee F, Nguyen DC, Sanz I, Martinez DR, Rothlauf PW, Bloyet LM, Whelan SPJ, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe JE Jr
Targeted Brain Tumor Therapy by Inhibiting the MDM2 Oncogene: In Vitro and In Vivo Antitumor Activity and Mechanism of Action.
1. Cells - published July 1, 2020
2. Punganuru SR, Artula V, Zhao W, Rajaei M, Deokar H, Zhang R, Buolamwini JK, Srivenugopal KS, Wang W
Making a difference in multi-data-set crystallography: simple and deterministic data-scaling/selection methods.
1. Acta Crystallogr D Struct Biol - published July 1, 2020
2. Assmann GM, Wang M, Diederichs K
Clinical targeting of HIV capsid protein with a long-acting small molecule.
1. Nature - published July 1, 2020
2. Link JO, Rhee MS, Tse WC, Zheng J, Somoza JR, Rowe W, Begley R, Chiu A, Mulato A, Hansen D, Singer E, Tsai LK, Bam RA, Chou CH, Canales E, Brizgys G, Zhang JR, Li J, Graupe M, Morganelli P, Liu Q, Wu Q, Halcomb RL, Saito RD, Schroeder SD, Lazerwith SE, Bondy S, Jin D, Hung M, Novikov N, Liu X, Villaseñor AG, Cannizzaro CE, Hu EY, Anderson RL, Appleby TC, Lu B, Mwangi J, Liclican A, Niedziela-Majka A, Papalia GA, Wong MH, Leavitt SA, Xu Y, Koditek D, Stepan GJ, Yu H, Pagratis N, Clancy S, Ahmadyar S, Cai TZ, Sellers S, Wolckenhauer SA, Ling J, Callebaut C, Margot N, Ram RR, Liu YP, Hyland R, Sinclair GI, Ruane PJ, Crofoot GE, McDonald CK, Brainard DM, Lad L, Swaminathan S, Sundquist WI, Sakowicz R, Chester AE, Lee WE, Daar ES, Yant SR, Cihlar T
De Novo Variants in the ATPase Module of MORC2 Cause a Neurodevelopmental Disorder with Growth Retardation and Variable Craniofacial Dysmorphism.
1. Am J Hum Genet - published July 1, 2020
2. Guillen Sacoto MJ, Tchasovnikarova IA, Torti E, Forster C, Andrew EH, Anselm I, Baranano KW, Briere LC, Cohen JS, Craigen WJ, Cytrynbaum C, Ekhilevitch N, Elrick MJ, Fatemi A, Fraser JL, Gallagher RC, Guerin A, Haynes D, High FA, Inglese CN, Kiss C, Koenig MK, Krier J, Lindstrom K, Marble M, Meddaugh H, Moran ES, Morel CF, Mu W, Muller EA 2nd, Nance J, Natowicz MR, Numis AL, Ostrem B, Pappas J, Stafstrom CE, Streff H, Sweetser DA, Szybowska M, Undiagnosed Diseases Network., Walker MA, Wang W, Weiss K, Weksberg R, Wheeler PG, Yoon G, Kingston RE, Juusola J
Inhibition of O-GlcNAc transferase renders prostate cancer cells dependent on CDK9.
1. Mol Cancer Res - published July 1, 2020
2. Itkonen HM, Poulose N, Steele RE, Martin SES, Levine ZG, Duveau DY, Carelli R, Singh R, Urbanucci A, Loda M, Thomas CJ, Mills IG, Walker S
Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP.
1. Elife - published July 1, 2020
2. Klug D, Goellner S, Kehrer J, Sattler J, Strauss L, Singer M, Lu C, Springer TA, Frischknecht F
A Stable Ferryl Porphyrin at the Active Site of Y463M BthA.
1. J Am Chem Soc - published July 1, 2020
2. Rizzolo K, Weitz AC, Cohen SE, Drennan CL, Hendrich MP, Elliott SJ
The potential impacts of early secreted antigenic target of 6 kDa (ESAT-6) of Mycobacterium tuberculosis on KSHV-infected cells.
1. J Med Virol - published July 1, 2020
2. Dai L, Jung BG, Chen J, Samten B, Forrest JC, Post SR, Qin Z
Paired refinement under the control of PAIREF.
1. IUCrJ - published July 1, 2020
2. Malý M, Diederichs K, Dohnálek J, Kolenko P
Tract-specific analysis improves sensitivity of spinal cord diffusion MRI to cross-sectional and longitudinal changes in amyotrophic lateral sclerosis.
1. Commun Biol - published July 1, 2020
2. Pisharady PK, Eberly LE, Cheong I, Manousakis G, Guliani G, Clark HB, Bathe M, Walk D, Lenglet C
Dual targeting of GSK3B and HDACs reduces tumor growth and improves survival in an ovarian cancer mouse model.
1. Gynecol Oncol - published July 1, 2020
2. Taylan E, Zayou F, Murali R, Karlan BY, Pandol SJ, Edderkaoui M, Orsulic S