Member Publications

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197 Member Publications for February 2023

Autophagy-dependent ferroptosis as a potential treatment for glioblastoma.
1. Front Oncol - published February 27, 2023
2. Xie Y, Hou T, Liu J, Zhang H, Liu X, Kang R, Tang D
Inorganic polyphosphate abets silencing of a sub-telomeric gene cluster in fission yeast.
1. MicroPubl Biol - published February 23, 2023
2. Sanchez AM, Garg A, Schwer B, Shuman S
Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders.
1. bioRxiv - published February 15, 2023
2. Li YD, Ma MW, Hassan MM, Hunkeler M, Teng M, Puvar K, Lumpkin R, Sandoval B, Jin CY, Ficarro SB, Wang MY, Xu S, Groendyke BJ, Sigua LH, Tavares I, Zou C, Tsai JM, Park PMC, Yoon H, Majewski FC, Marto JA, Qi J, Nowak RP, Donovan KA, Słabicki M, Gray NS, Fischer ES, Ebert BL
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways.
1. J Med Chem - published February 9, 2023
2. Kandasamy P, Mori S, Matsuda S, Erande N, Datta D, Willoughby JLS, Taneja N, O'Shea J, Bisbe A, Manoharan RM, Yucius K, Nguyen T, Indrakanti R, Gupta S, Gilbert JA, Racie T, Chan A, Liu J, Hutabarat R, Nair JK, Charisse K, Maier MA, Rajeev KG, Egli M, Manoharan M
Membrane Proteins in Plant Salinity Stress Perception, Sensing, and Response.
1. J Membr Biol - published February 9, 2023
2. Banik S, Dutta D
Structures of BIRC6-client complexes provide a mechanism of Smac-mediated release of caspases.
1. Science - published February 9, 2023
2. Hunkeler M, Jin CY, Fischer ES
Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
1. Science - published February 9, 2023
2. Ehrmann JF, Grabarczyk DB, Heinke M, Deszcz L, Kurzbauer R, Hudecz O, Shulkina A, Gogova R, Meinhart A, Versteeg GA, Clausen T
Dual kinase inhibitor for EGFR mutants and ErbB2 limit breast cancer.
1. Biochem Biophys Res Commun - published February 9, 2023
2. Goel PN, Zhang H, Murali R, Zheng C, Ji MQ, Patterson A, Grover P, Greene M
Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor.
1. ACS Med Chem Lett - published February 9, 2023
2. Mamai A, Chau AM, Wilson BJ, Watson ID, Joseph BB, Subramanian PR, Morshed MM, Morin JA, Prakesch MA, Lu T, Connolly P, Kuntz DA, Pomroy NC, Poda G, Nguyen K, Marcellus R, Strathdee G, Theriault B, Subramaniam R, Mohammed M, Abibi A, Chan M, Winston J, Kiyota T, Undzys E, Aman A, Austin N, Du Jardin M, Packman K, Phillippar U, Attar R, Edwards J, O'Meara J, Uehling DE, Al-Awar R, Privé GG, Isaac MB
Chloride Ions Are Required for Thermosipho africanus MurJ Function.
1. mBio - published February 8, 2023
2. Kumar S, Mollo A, Rubino FA, Kahne D, Ruiz N
The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
1. Nature - published February 8, 2023
2. Li YL, Langley CA, Azumaya CM, Echeverria I, Chesarino NM, Emerman M, Cheng Y, Gross JD
An E1-E2 fusion protein primes antiviral immune signalling in bacteria.
1. Nature - published February 8, 2023
2. Ledvina HE, Ye Q, Gu Y, Sullivan AE, Quan Y, Lau RK, Zhou H, Corbett KD, Whiteley AT
Quality research needs good working conditions.
1. Nat Hum Behav - published February 8, 2023
2. Rahal RM, Fiedler S, Adetula A, Berntsson RP, Dirnagl U, Feld GB, Fiebach CJ, Himi SA, Horner AJ, Lonsdorf TB, Schönbrodt F, Silan MAA, Wenzler M, Azevedo F
SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.
1. Stem Cell Reports - published February 8, 2023
2. Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, Li JZ, Ding VW, Matsumoto S, Maishan M, Sreekumar B, Simoneau C, Nazarenko I, Tomlinson MG, Khan K, von Gottberg A, Sigal A, Looney MR, Fragiadakis GK, Jablons DM, Langelier CR, Matthay M, Krummel M, Erle DJ, Combes AJ, Sil A, Ott M, Kratz JR, Roose JP
The COVID19-NMR Consortium: A Public Report on the Impact of this New Global Collaboration.
1. Angew Chem Int Ed Engl - published February 7, 2023
2. Duchardt-Ferner E, Ferner J, Fürtig B, Hengesbach M, Richter C, Schlundt A, Sreeramulu S, Wacker A, Weigand JE, Wirmer-Bartoschek J, Schwalbe H
Learning Correlations between Internal Coordinates to Improve 3D Cartesian Coordinates for Proteins.
1. J Chem Theory Comput - published February 7, 2023
2. Li J, Zhang O, Lee S, Namini A, Liu ZH, Teixeira JMC, Forman-Kay JD, Head-Gordon T
Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation.
1. Annu Rev Immunol - published February 7, 2023
2. Fu J, Wu H
Severe Allergic Dysregulation Due to A Gain of Function Mutation in the Transcription Factor STAT6.
1. J Allergy Clin Immunol - published February 7, 2023
2. Baris S, Benamar M, Chen Q, Catak MC, Martínez-Blanco M, Wang M, Fong J, Massaad MJ, Sefer AP, Kara A, Babayeva R, Eltan SB, Yucelten AD, Bozkurtlar E, Cinel L, Karakoc-Aydiner E, Zheng Y, Wu H, Ozen A, Schmitz-Abe K, Chatila TA
Insight into the Structural Basis for Dual Nucleic Acid-Recognition by the Scaffold Attachment Factor B2 Protein.
1. Int J Mol Sci - published February 7, 2023
2. Korn SM, Von Ehr J, Dhamotharan K, Tants JN, Abele R, Schlundt A
Deep neural network automated segmentation of cellular structures in volume electron microscopy.
1. J Cell Biol - published February 6, 2023
2. Gallusser B, Maltese G, Di Caprio G, Vadakkan TJ, Sanyal A, Somerville E, Sahasrabudhe M, O'Connor J, Weigert M, Kirchhausen T
Distinct Energy-Coupling Factor Transporter Subunits Enable Flavin Acquisition and Extracytosolic Trafficking for Extracellular Electron Transfer in Listeria monocytogenes.
1. mBio - published February 6, 2023
2. Rivera-Lugo R, Huang S, Lee F, Méheust R, Iavarone AT, Sidebottom AM, Oldfield E, Portnoy DA, Light SH
Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder.
1. Nat Commun - published February 6, 2023
2. Kordon SP, Dutka P, Adamska JM, Bandekar SJ, Leon K, Erramilli SK, Adams B, Li J, Kossiakoff AA, Araç D
The Actin Network Interfacing Diverse Integrin-Mediated Adhesions.
1. Biomolecules - published February 4, 2023
2. Geiger B, Boujemaa-Paterski R, Winograd-Katz SE, Balan Venghateri J, Chung WL, Medalia O
A Buried Water Network Modulates the Activity of the Escherichia coli Disulphide Catalyst DsbA.
1. Antioxidants (Basel) - published February 4, 2023
2. Wang G, Qin J, Verderosa AD, Hor L, Santos-Martin C, Paxman JJ, Martin JL, Totsika M, Heras B
Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia.
1. J Med Chem - published February 3, 2023
2. Kaneshige A, Bai L, Wang M, McEachern D, Meagher JL, Xu R, Kirchhoff PD, Wen B, Sun D, Stuckey JA, Wang S
Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers.
1. Org Lett - published February 3, 2023
2. Ghosh A, Akabane-Nakata M, Kundu J, Harp JM, Madaoui M, Egli M, Manoharan M, Sinha S
Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity.
1. Nat Commun - published February 3, 2023
2. Chen WH, Hajduczki A, Martinez EJ, Bai H, Matz H, Hill TM, Lewitus E, Chang WC, Dawit L, Peterson CE, Rees PA, Ajayi AB, Golub ES, Swafford I, Dussupt V, David S, Mayer SV, Soman S, Kuklis C, Corbitt C, King J, Choe M, Sankhala RS, Thomas PV, Zemil M, Wieczorek L, Hart T, Duso D, Kummer L, Yan L, Sterling SL, Laing ED, Broder CC, Williams JK, Davidson E, Doranz BJ, Krebs SJ, Polonis VR, Paquin-Proulx D, Rolland M, Reiley WW, Gromowski GD, Modjarrad K, Dooley H, Joyce MG
Aim18p and Aim46p are chalcone isomerase (CHI)-domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae.
1. J Biol Chem - published February 3, 2023
2. Schmitz JM, Wolters JF, Murray NH, Guerra RM, Bingman CA, Hittinger CT, Pagliarini DJ
Cryo-EM structure of the RADAR supramolecular anti-phage defense complex.
1. Cell - published February 3, 2023
2. Duncan-Lowey B, Tal N, Johnson AG, Rawson S, Mayer ML, Doron S, Millman A, Melamed S, Fedorenko T, Kacen A, Brandis A, Mehlman T, Amitai G, Sorek R, Kranzusch PJ
A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo.
1. Nat Chem Biol - published February 2, 2023
2. Kaneshige A, Bai L, Wang M, McEachern D, Meagher JL, Xu R, Wang Y, Jiang W, Metwally H, Kirchhoff PD, Zhao L, Jiang H, Wang M, Wen B, Sun D, Stuckey JA, Wang S
The F-box protein UFO controls flower development by redirecting the master transcription factor LEAFY to new cis-elements.
1. Nat Plants - published February 2, 2023
2. Rieu P, Turchi L, Thévenon E, Zarkadas E, Nanao M, Chahtane H, Tichtinsky G, Lucas J, Blanc-Mathieu R, Zubieta C, Schoehn G, Parcy F
Antibody-based protection against respiratory syncytial virus in mice and their offspring through vectored immunoprophylaxis.
1. Gene Ther - published February 2, 2023
2. Rghei AD, Yates JGE, Lopes JA, Zhan X, Guilleman MM, Pei Y, van Lieshout LP, Santry LA, Bridle BW, Karimi K, Thompson B, Susta L, Crowe JE Jr, Wootton SK
Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence.
1. NPJ Biofilms Microbiomes - published February 2, 2023
2. Razvi E, Whitfield GB, Reichhardt C, Dreifus JE, Willis AR, Gluscencova OB, Gloag ES, Awad TS, Rich JD, da Silva DP, Bond W, Le Mauff F, Sheppard DC, Hatton BD, Stoodley P, Reinke AW, Boulianne GL, Wozniak DJ, Harrison JJ, Parsek MR, Howell PL
Naturally acquired antibodies to gametocyte antigens are associated with reduced transmission of Plasmodium vivax gametocytes to Anopheles arabiensis mosquitoes.
1. Front Cell Infect Microbiol - published February 2, 2023
2. Tebeje SK, Chali W, Hailemeskel E, Ramjith J, Gashaw A, Ashine T, Nebret D, Esayas E, Emiru T, Tsegaye T, Teelen K, Lanke K, Takashima E, Tsuboi T, Salinas ND, Tolia NH, Narum D, Drakeley C, Witkowski B, Vantaux A, Jore MM, Stone WJR, Hansen IS, Tadesse FG, Bousema T
WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma.
1. Genes Dev - published February 2, 2023
2. Mitchell K, Sprowls SA, Arora S, Shakya S, Silver DJ, Goins CM, Wallace L, Roversi G, Schafer R, Kay K, Miller TE, Lauko A, Bassett J, Kashyap A, D'Amato Kass J, Mulkearns-Hubert EE, Johnson S, Alvarado J, Rich JN, Holland EC, Paddison PJ, Patel AP, Stauffer SR, Hubert CG, Lathia JD
Recognition of transcription terminators during retrotransposition: How to keep a group II intron quiet.
1. Mol Cell - published February 2, 2023
2. Haack DB, Toor N
RCSB Protein Data Bank: Efficient Searching and Simultaneous Access to One Million Computed Structure Moddels Alongside the PDB Structures Enabled by Architectural Advances.
1. J Mol Biol - published February 2, 2023
2. Bittrich S, Bhikadiya C, Bi C, Chao H, Duarte JM, Dutta S, Fayazi M, Henry J, Khokhriakov I, Lowe R, Piehl DW, Segura J, Vallat B, Voigt M, Westbrook JD, Burley SK, Rose Y
Structure of metallochaperone in complex with the cobalamin-binding domain of its target mutase provides insight into cofactor delivery.
1. Proc Natl Acad Sci U S A - published February 2, 2023
2. Vaccaro FA, Born DA, Drennan CL
An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options.
1. Proc Natl Acad Sci U S A - published February 2, 2023
2. Kang JY, Mishanina TV, Bao Y, Chen J, Llewellyn E, Liu J, Darst SA, Landick R
A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products.
1. Proc Natl Acad Sci U S A - published February 2, 2023
2. Bhardwaj M, Cui Z, Daniel Hankore E, Moonschi FH, Saghaeiannejad Esfahani H, Kalkreuter E, Gui C, Yang D, Phillips GN Jr, Thorson JS, Shen B, Van Lanen SG
Targeting Oncolytic Adenoviruses to Cancer Cells Using a Designed Ankyrin Repeat Protein (DARPin) Lipocalin-2 (LCN2) Fusion Protein.
1. Hum Gene Ther - published February 2, 2023
2. Schellhorn S, Brücher D, Wolff N, Schröer K, Sallard E, Mese K, Zhang W, Ehrke-Schulz E, Thevenod F, Plückthun A, Ehrhardt A
Binding by calmodulin is coupled to transient unfolding of the third FF domain of Prp40A.
1. Protein Sci - published February 2, 2023
2. Casas AD, Cordoba JJ, Ferrer BJ, Balakrishnan S, Wurm JE, Pastrana-Ríos B, Chazin WJ
Radical Transport Facilitated by a Proton Transfer Network at the Subunit Interface of Ribonucleotide Reductase.
1. J Am Chem Soc - published February 2, 2023
2. Cui C, Song DY, Drennan CL, Stubbe J, Nocera DG
Elucidation of the GSK3α Structure Informs the Design of Novel, Paralog-Selective Inhibitors.
1. ACS Chem Neurosci - published February 2, 2023
2. Amaral B, Capacci A, Anderson T, Tezer C, Bajrami B, Lulla M, Lucas B, Chodaparambil JV, Marcotte D, Kumar PR, Murugan P, Spilker K, Cullivan M, Wang T, Peterson AC, Enyedy I, Ma B, Chen T, Yousaf Z, Calhoun M, Golonzhka O, Dillon GM, Koirala S
Author Correction: Plant-specific features of respiratory supercomplex I + III(2) from Vigna radiata.
1. Nat Plants - published February 2, 2023
2. Maldonado M, Fan Z, Abe KM, Letts JA
Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels.
1. Nat Struct Mol Biol - published February 2, 2023
2. Shen Q, Feng Q, Wu C, Xiong Q, Tian T, Yuan S, Shi J, Bedwell GJ, Yang R, Aiken C, Engelman AN, Lusk CP, Lin C, Xiong Y
The yeast ALA synthase C-terminus positively controls enzyme structure and function.
1. Protein Sci - published February 2, 2023
2. Tran JU, Brown BL
Rapid Biocatalytic Synthesis of Aromatic Acid CoA Thioesters utilizing Microbial Aromatic Acid CoA Ligases.
1. Chembiochem - published February 2, 2023
2. Chaudhury D, Torkelson ER, Meyers KA, Acheson JF, Landucci LM, Pu Y, Sun Z, Tonelli M, Bingman CA, Smith RA, Karlen SD, Mansfield SD, Ralph J, Fox BG
MicroED in drug discovery.
1. Curr Opin Struct Biol - published February 2, 2023
2. Danelius E, Patel K, Gonzalez B, Gonen T
Comprehensive molecular and clinical characterization of NUP98 fusions in pediatric acute myeloid leukemia.
1. Haematologica - published February 2, 2023
2. Bertrums EJM, Smith JL, Harmon L, Ries RE, Wang YJ, Alonzo TA, Menssen AJ, Chisholm KM, Leonti AR, Tarlock K, Ostronoff F, Pogosova-Agadjanyan EL, Kaspers GJL, Hasle H, Dworzak M, Walter C, Muhlegger N, Morerio C, Pardo L, Hirsch B, Raimondi S, Cooper TM, Aplenc R, Gamis AS, Kolb EA, Farrar JE, Stirewalt D, Ma X, Shaw TI, Furlan SN, Brodersen LE, Loken MR, Van den Heuvel-Eibrink MM, Zwaan CM, Triche TJ, Goemans BF, Meshinchi S
A shape-shifting nuclease unravels structured RNA.
1. Nat Struct Mol Biol - published February 2, 2023
2. Meze K, Axhemi A, Thomas DR, Doymaz A, Joshua-Tor L
Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease.
1. Nat Med - published February 2, 2023
2. Mehta RS, Mayers JR, Zhang Y, Bhosle A, Glasser NR, Nguyen LH, Ma W, Bae S, Branck T, Song K, Sebastian L, Pacheco JA, Seo HS, Clish C, Dhe-Paganon S, Ananthakrishnan AN, Franzosa EA, Balskus EP, Chan AT, Huttenhower C
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor.
1. Nat Chem Biol - published February 2, 2023
2. Darabedian N, Ji W, Fan M, Lin S, Seo HS, Vinogradova EV, Yaron TM, Mills EL, Xiao H, Senkane K, Huntsman EM, Johnson JL, Che J, Cantley LC, Cravatt BF, Dhe-Paganon S, Stegmaier K, Zhang T, Gray NS, Chouchani ET
Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1.
1. J Med Chem - published February 2, 2023
2. Lu W, Liu Y, Gao Y, Geng Q, Gurbani D, Li L, Ficarro SB, Meyer CJ, Sinha D, You I, Tse J, He Z, Ji W, Che J, Kim AY, Yu T, Wen K, Anderson KC, Marto JA, Westover KD, Zhang T, Gray NS
DIMPLE: deep insertion, deletion, and missense mutation libraries for exploring protein variation in evolution, disease, and biology.
1. Genome Biol - published February 2, 2023
2. Macdonald CB, Nedrud D, Grimes PR, Trinidad D, Fraser JS, Coyote-Maestas W
ModelCIF: An extension of PDBx/mmCIF data representation for computed structure models.
1. J Mol Biol - published February 2, 2023
2. Vallat B, Tauriello G, Bienert S, Haas J, Webb BM, Žídek A, Zheng W, Peisach E, Piehl DW, Anischanka I, Sillitoe I, Tolchard J, Varadi M, Baker D, Orengo C, Zhang Y, Hoch JC, Kurisu G, Patwardhan A, Velankar S, Burley SK, Sali A, Schwede T, Berman HM, Westbrook JD
The cofactor-dependent folding mechanism of Drosophila cryptochrome revealed by single-molecule pulling experiments.
1. Nat Commun - published February 2, 2023
2. Foroutannejad S, Good LL, Lin C, Carter ZI, Tadesse MG, Lucius AL, Crane BR, Maillard RA
Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1.
1. Nat Commun - published February 2, 2023
2. Schmidpeter PAM, Petroff JT 2nd, Khajoueinejad L, Wague A, Frankfater C, Cheng WWL, Nimigean CM, Riegelhaupt PM
Structural consequences of turnover-induced homocitrate loss in nitrogenase.
1. Nat Commun - published February 2, 2023
2. Warmack RA, Maggiolo AO, Orta A, Wenke BB, Howard JB, Rees DC
Host Immune Responses to Surface S-Layer Proteins (SLPs) of Clostridioides difficile.
1. Microorganisms - published February 2, 2023
2. Chandra H, Kovall RA, Yadav JS, Sun X
A robust approach for MicroED sample preparation of lipidic cubic phase embedded membrane protein crystals.
1. Nat Commun - published February 2, 2023
2. Martynowycz MW, Shiriaeva A, Clabbers MTB, Nicolas WJ, Weaver SJ, Hattne J, Gonen T
Author Correction: The NSL complex maintains nuclear architecture stability via lamin A/C acetylation.
1. Nat Cell Biol - published February 2, 2023
2. Karoutas A, Szymanski W, Rausch T, Guhathakurta S, Rog-Zielinska EA, Peyronnet R, Seyfferth J, Chen HR, de Leeuw R, Herquel B, Kimura H, Mittler G, Kohl P, Medalia O, Korbel JO, Akhtar A
Rhesus macaque Bcl-6/Bcl-xL B cell immortalization: Discovery of HIV-1 neutralizing antibodies from lymph node.
1. J Immunol Methods - published February 2, 2023
2. Samsel J, Boswell KL, Watkins TA, Ambrozak DR, Mason R, Yamamoto T, Ko S, Yang Y, Zhou T, Doria-Rose NA, Foulds KE, Roederer M, Mascola JR, Kwong PD, Gama L, Koup RA
Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter.
1. Nat Commun - published February 2, 2023
2. Davies JS, Currie MJ, North RA, Scalise M, Wright JD, Copping JM, Remus DM, Gulati A, Morado DR, Jamieson SA, Newton-Vesty MC, Abeysekera GS, Ramaswamy S, Friemann R, Wakatsuki S, Allison JR, Indiveri C, Drew D, Mace PD, Dobson RCJ
Additive energetic contributions of multiple peptide positions determine the relative promiscuity of viral and human sequences for PDZ domain targets.
1. Protein Sci - published February 2, 2023
2. Tahti EF, Blount JM, Jackson SN, Gao M, Gill NP, Smith SN, Pederson NJ, Rumph SN, Struyvenberg SA, Mackley IGP, Madden DR, Amacher JF
Potently neutralizing human monoclonal antibodies against the zoonotic pararubulavirus Sosuga virus.
1. JCI Insight - published February 2, 2023
2. Parrington HM, Kose N, Armstrong E, Handal LS, Diaz S, Reidy J, Dong J, Stewart-Jones GB, Shrivastava-Ranjan P, Jain S, Albariño CG, Carnahan RH, Crowe JE
Dimensional Reduction for Single-Molecule Imaging of DNA and Nucleosome Condensation by Polyamines, HP1α and Ki-67.
1. J Phys Chem B - published February 2, 2023
2. Benning NA, Kæstel-Hansen J, Rashid F, Park S, Merino Urteaga R, Liao TW, Hao J, Berger JM, Hatzakis NS, Ha T
Methods for Cryo-EM Single Particle Reconstruction of Macromolecules Having Continuous Heterogeneity.
1. J Mol Biol - published February 2, 2023
2. Toader B, Sigworth FJ, Lederman RR
Linking medicinal cannabis to autotaxin-lysophosphatidic acid signaling.
1. Life Sci Alliance - published February 1, 2023
2. Eymery MC, McCarthy AA, Hausmann J
Horizontal transfer of the rfb cluster in Leptospira is a genetic determinant of serovar identity.
1. Life Sci Alliance - published February 1, 2023
2. Nieves C, Vincent AT, Zarantonelli L, Picardeau M, Veyrier FJ, Buschiazzo A
N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy.
1. Elife - published February 1, 2023
2. Okuma H, Hord JM, Chandel I, Venzke D, Anderson ME, Walimbe AS, Joseph S, Gastel Z, Hara Y, Saito F, Matsumura K, Campbell KP
Structural basis for substrate selection by the SARS-CoV-2 replicase.
1. Nature - published February 1, 2023
2. Malone BF, Perry JK, Olinares PDB, Lee HW, Chen J, Appleby TC, Feng JY, Bilello JP, Ng H, Sotiris J, Ebrahim M, Chua EYD, Mendez JH, Eng ET, Landick R, Götte M, Chait BT, Campbell EA, Darst SA
Acyclic (S)-Glycol Nucleic Acid (S-GNA) Modification of siRNAs Improves the Safety of RNAi Therapeutics While Maintaining Potency.
1. RNA - published February 1, 2023
2. Egli M, Schlegel MK, Manoharan M
Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers.
1. BMC Biol - published February 1, 2023
2. Gipson GR, Nolan K, Kattamuri C, Kenny AP, Agricola Z, Edwards NA, Zinski J, Czepnik M, Mullins MC, Zorn AM, Thompson TB
Anti-CRISPR protein AcrIIC5 inhibits CRISPR-Cas9 by occupying the target DNA binding pocket.
1. J Mol Biol - published February 1, 2023
2. Hwang S, Shah M, Garcia B, Hashem N, Davidson AR, Moraes TF, Maxwell KL
Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability.
1. Proc Natl Acad Sci U S A - published February 1, 2023
2. An SJ, Mohanty J, Tome F, Suzuki Y, Lax I, Schlessinger J
Purification and structure of luminal domain C of human Niemann-Pick C1 protein.
1. Acta Crystallogr F Struct Biol Commun - published February 1, 2023
2. Odongo L, Zadrozny KK, Diehl WE, Luban J, White JM, Ganser-Pornillos BK, Tamm LK, Pornillos O
Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy.
1. EMBO J - published February 1, 2023
2. Picchianti L, Sánchez de Medina Hernández V, Zhan N, Irwin NA, Groh R, Stephani M, Hornegger H, Beveridge R, Sawa-Makarska J, Lendl T, Grujic N, Naumann C, Martens S, Richards TA, Clausen T, Ramundo S, Karagöz GE, Dagdas Y
CD4 binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wild-type animals.
1. Sci Immunol - published February 1, 2023
2. Gristick HB, Hartweger H, Loewe M, van Schooten J, Ramos V, Oliveira TY, Nishimura Y, Koranda NS, Wall A, Yao KH, Poston D, Gazumyan A, Wiatr M, Horning M, Keeffe JR, Hoffmann MAG, Yang Z, Abernathy ME, Dam KA, Gao H, Gnanapragasam PNP, Kakutani LM, Pavlovitch-Bedzyk AJ, Seaman MS, Howarth M, McGuire AT, Stamatatos L, Martin MA, West AP Jr, Nussenzweig MC, Bjorkman PJ
Role of the histone tails in histone octamer transfer.
1. Nucleic Acids Res - published February 1, 2023
2. Lorch Y, Kornberg RD, Maier-Davis B
Inhibiting mitochondrial inflammation through Drp1/HK1/NLRP3 pathway: A mechanism of alpinetin attenuated aging-associated cognitive impairment.
1. Phytother Res - published February 1, 2023
2. Chen Y, Yang C, Zou M, Wang D, Sheng R, Zhan M, Chen Q, Yang W, Liu X, Xu S
Single-molecule dynamics of DNA gyrase in evolutionarily distant bacteria Mycobacterium tuberculosis and E. coli.
1. J Biol Chem - published February 1, 2023
2. Galvin CJ, Hobson M, Meng JX, Ierokomos A, Ivanov IE, Berger JM, Bryant Z
Deciphering Bacteriophage T5 Host Recognition Mechanism and Infection Trigger.
1. J Virol - published February 1, 2023
2. Degroux S, Effantin G, Linares R, Schoehn G, Breyton C
PrePCI: A structure- and chemical similarity-informed database of predicted protein compound interactions.
1. Protein Sci - published February 1, 2023
2. Trudeau SJ, Hwang H, Mathur D, Begum K, Petrey D, Murray D, Honig B
Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.
1. Nat Struct Mol Biol - published February 1, 2023
2. Kim SK, Dickinson MS, Finer-Moore J, Guan Z, Kaake RM, Echeverria I, Chen J, Pulido EH, Sali A, Krogan NJ, Rosenberg OS, Stroud RM
RAD51 filament formation, dynamics, and regulation.
1. Biophys J - published February 1, 2023
2. Cash K, Spies M
Development of an aptamer-based screening for identification and characterization of novel RNA therapeutics using switchSENSE® technology.
1. Biophys J - published February 1, 2023
2. Weller M, Sattler M, Rant U
Coarse-grained RNA simulations with concerted c2'/c3'-endo sugar pucker transitions.
1. Biophys J - published February 1, 2023
2. Wu Y, Alessandri R, Coraor A, Peng X, Sosnick TR, Pablo JJ
Interaction dynamics of disordered proteins from single-molecule spectroscopy.
1. Biophys J - published February 1, 2023
2. Schuler B
Establishment of an in vivo human engineered heart tissue platform to model iron overload cardiomyopathy.
1. Biophys J - published February 1, 2023
2. Modak SS, Greenberg L, Stump W, Li W, Huebsch N, Greenberg MJ
Solution structure of poly(UG) RNA reveals a new fold that drives gene silencing.
1. Biophys J - published February 1, 2023
2. Escobar CA, Petersen RJ, Tonelli M, Fan L, Wang YX, Yan J, Kennedy SG, Butcher SE
Structural characterization of mini-PCDH15 proteins for Usher syndrome type 1F therapy.
1. Biophys J - published February 1, 2023
2. De-la-Torre P, Brower J, Narui Y, Wen H, Ivanchenko M, Corey DP, Sotomayor M, Indzhykulian AA
Probing structural topology and dynamics of human KCNE3 membrane protein in lipid bilayers using site-directed spin labeling and electron paramagnetic resonance spectroscopy.
1. Biophys J - published February 1, 2023
2. Williams PL, Campbell C, Scheyer M, Hussain M, Begum A, Fonseca S, Dabney P, Carter H, Sanders CR, Lorigan GA, Sahu ID
Principles of DNA cleavage in CRISPR-Cas9.
1. Biophys J - published February 1, 2023
2. Ahsan M, Nierzwicki Ł, East KW, Binz J, Hsu RV, Arantes PR, Skeens E, Pacesa M, Jinek M, Lisi GP, Palermo G
Ribosome hyper-swivel head domain motions are required for translocation and resetting.
1. Biophys J - published February 1, 2023
2. Girodat DJ, Nishima W, Holm M, Rundlet EJ, Prajapati JD, Amaya JLA, Fischer K, Blanchard SC, Sanbonmatsu KY
Comparing structural dynamic properties of diseases causing mutations of KCNE3 with wild-type KCNE3 in a lipid bilayer membrane using molecular dynamics simulations.
1. Biophys J - published February 1, 2023
2. Asare I, Miranda Moura AC, Aguado AJ, Morales BM, Cruz MF, Alston S, Kravats A, Sanders CR, Lorigan GA, Sahu ID
Mechanism of sliding clamp loading during DNA replication and repair in atomic detail.
1. Biophys J - published February 1, 2023
2. Liu X, Gaubitz C, Pajak J, Kelch BA
Structural investigation of 2'-azido-2'-deoxyribonucleoside-5'-diphosphate inhibition of class Ia Escherichia coli ribonucleotide reductase.
1. Biophys J - published February 1, 2023
2. Westmoreland DE, Feliciano P, Drennan CL
Conformational rearrangements associated with Panx1 channel gating.
1. Biophys J - published February 1, 2023
2. Ehrlich JJ, Henze EK, Kawate T
Lilac: Enhanced actin imaging with an optogenetic Lifeact.
1. Biophys J - published February 1, 2023
2. Kroll KL, French A, Rock RS, Sosnick TR
Structural heterogeneity of nuclear pores in yeast.
1. Biophys J - published February 1, 2023
2. Singh D, Soni N, Echeverria I, Shaikh F, Suslov S, Fernandez-Martinez J, Upla P, Ludtke S, Akey CW, Sali A, Rout MP, Villa E
High-resolution structures using cryo-EM guide drug development for neuromyelitis optica (NMO).
1. Biophys J - published February 1, 2023
2. Gupta M, Nelson A, Pourmal S, Bennett J, Stroud RM
Supramolecular organization of the postsynaptic density for trans-synaptic alignment in excitatory synapse observed by cryo-electron tomography.
1. Biophys J - published February 1, 2023
2. Sun R, Wilson L, Haider M, Wang X, Alten B, Zhou Q
Drug discovery targeting SARS-CoV-2 membrane fusion.
1. Biophys J - published February 1, 2023
2. Yang K, Wang C, Kreutzberger AJB, Ojha R, Kuivanen S, Couoh-Cardel S, Muratcioglu S, Eisen TJ, White KI, Pfuetzner R, Kuriyan J, Vapalahti O, Balistreri G, Kirchhausen T, Brunger AT
Using solid-supported membrane electrophysiology to probe the transport mechanism of EmrE.
1. Biophys J - published February 1, 2023
2. Brousseau M, Thomas NE, Spreacker PJ, Henzler-Wildman KA
Rapid extraction of time-dependent behaviors of endo-lysosomal structures and their cargo aided by deep learning.
1. Biophys J - published February 1, 2023
2. Kæstel-Hansen J, Kreutzberger A, Kirchhausen T, Hatzakis NS
MIDLS - Membrane detection in cryo-EM using deep level sets.
1. Biophys J - published February 1, 2023
2. Cameron CJ, Sigworth FJ, Gerstein M, Tagare HD
Re-assessing the role of the helix bundle crossing in NaK.
1. Biophys J - published February 1, 2023
2. Kurauskas V, Tonelli M, Henzler-Wildman KA
A central helical switch controls integrated stress response signaling via eIF2B conformation and assembly.
1. Biophys J - published February 1, 2023
2. Lawrence R, Shoemaker S, Deal A, Wang L, Marqusee S, Walter P
Unexpected, pervasive, conserved secondary structure in highly charged protein regions.
1. Biophys J - published February 1, 2023
2. Triandafillou C, Pan R, Drummond DA, Dinner A
Structural basis for the recruitment of PARP4 and NAD(+)to the vault complex.
1. Biophys J - published February 1, 2023
2. Lodwick JE, Zhao M
Structural basis for phage single gene lysis protein mechanisms.
1. Biophys J - published February 1, 2023
2. Li YE, Orta AK, Clemons WM Jr
Lipid translocation in the omega-3 fatty-acid transporter MFSD2A.
1. Biophys J - published February 1, 2023
2. Tung Faat Lai L, Chi N, Lei HT, Marc GJ, Mu X, Gonen T, Matthies D
Functional characterization of gating polarity in CNBD channels across phylogenetically diverse species.
1. Biophys J - published February 1, 2023
2. Lin JL, Kaur G, Iyer A, Chanda B
Conformational dynamics and pH-regulation in ApcT.
1. Biophys J - published February 1, 2023
2. Kazmier KN, Peng D, Verhalen B, Matthieu J, Quick M, Stein RA, Mchaourab HS
Using HDX-MS to probe the dynamics and denatured state of GlpG, a helical membrane protein.
1. Biophys J - published February 1, 2023
2. Schroeter AL, Kanwal S, Hong H, Sosnick TR
Delivery of nonbiologically-compatible membrane protein constructs to mammalian cells for functional characterization.
1. Biophys J - published February 1, 2023
2. Van Horn WD, Mann HF, Shah KH, Luu DD, Pratt AM, Bennett CF, Clowes KR, Sanders CR
From integrative atomic-resolution ensembles of disordered proteins to simulations of phase-separated condensates.
1. Biophys J - published February 1, 2023
2. Stelzl LS, Pietrek LM, Ping X, Holla A, Sikora M, Koefinger J, Dormann D, Schuler B, Zweckstetter M, Hummer G
Key role of an alpha-helical lid in driving the target DNA toward catalysis in CRISPR-Cas12a.
1. Biophys J - published February 1, 2023
2. Saha A, Ahsan M, Arantes PR, Chanez C, Schmitz M, Jinek M, Palermo G
Designing occluded-open Env-based immunogens for HIV-1.
1. Biophys J - published February 1, 2023
2. DeLaitsch AT, Liendo N, Bjorkman PJ
Examining HIV-1 envelope conformational transitions at high temporal resolution.
1. Biophys J - published February 1, 2023
2. Bennett AL, Saunders C, Bililign Y, Williams A, Montani M, Acharya P, Haynes B, Henderson RC
Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk and enhanced NTD dynamics.
1. Biophys J - published February 1, 2023
2. Anand GS, Braet S, Buckley T, Venkatakrishnan V, Dam KM, Bjorkman PJ
A curated AlphaFold 2/AlphaFill cadherinosome.
1. Biophys J - published February 1, 2023
2. Wen H, Weng WH, Sotomayor M
Engineering of the high-affinity chemokine CXCL13 to screen CXCR5 antagonists to treat cancer and autoimmune diseases.
1. Biophys J - published February 1, 2023
2. Ramu M, Rosenberg E, Kartz S, Foss F, Lolis EJ
Structure of a non-mammalian cadherin heterodimer suggests a general binding mechanism essential for hair-cell mechanotransduction.
1. Biophys J - published February 1, 2023
2. Scheib E, Nisler CR, Sotomayor M
Structure and dynamics of off-target effects in CRISPR-Cas9.
1. Biophys J - published February 1, 2023
2. Arantes PR, Mitchell BP, Saha A, Nierzwicki L, Pacesa M, Jinek M, Palermo G
Structural basis of metal import by Nramp family transporters.
1. Biophys J - published February 1, 2023
2. Ray S, Berry SP, Gaudet R
Structures and gating of the Arabidopsis mechanosensitive ion channel MSL10.
1. Biophys J - published February 1, 2023
2. Zhang J, Ozturk TN, Maksaev G, Rau MJ, Fitzpatrick JAJ, Yuan P
Template-free prediction of a new monotopic membrane protein fold and oligomeric assembly by AlphaFold2.
1. Biophys J - published February 1, 2023
2. Gulsevin A, Han B, Porta J, Mchaourab H, Meiler J, Kenworthy AK
A kinetic mechanism for U6 snRNP biogenesis obtained by single molecule fluorescence colocalization microscopy.
1. Biophys J - published February 1, 2023
2. Liu Y, Nomura Y, Butcher SE, Hoskins AA
The functional and molecular determinants of stress-induced mRNA condensation.
1. Biophys J - published February 1, 2023
2. Glauninger H, Bard J, Wong Hickernell C, Sosnick TR, Wallace E, Drummond DA
Membrane phospholipids induce moderate positive cooperativity in closed pacemaker channels.
1. Biophys J - published February 1, 2023
2. Idikuda V, Roy Chowdhury S, Goldsmith RH, Chanda B
Muscle-type nicotinic acetylcholine receptor structure, function, and pharmacology.
1. Biophys J - published February 1, 2023
2. Goswami U, Mahfuzur Rahman M, Teng J, Hibbs RE
Heteromeric LRRC8 channel assemblies and their impact on channel activity.
1. Biophys J - published February 1, 2023
2. Lehmann EF, Rutz S, Deneka D, Dittmann A, Sawicka M, Dutzler R
Investigating the sequence properties that govern disorder and secretion of bacterial virulence proteins.
1. Biophys J - published February 1, 2023
2. Mukinay C, Baxa M, Sosnick TR, Clark PL
Geometric alignment of aminoacyl-tRNA relative to catalytic centers of the ribosome underpins accurate mRNA decoding.
1. Biophys J - published February 1, 2023
2. Girodat DJ, Wieden HJ, Blanchard SC, Sanbonmatsu KY
Structural and evolutionary studies on cephalopod chemotactile receptors.
1. Biophys J - published February 1, 2023
2. Kang G, Allard C, Valencia-Montoya W, Joo Kim J, van Giesen L, Kilian P, Bai X, Bellono N, Hibbs RE
Context-specific inhibition of translation in mycobacterium.
1. Biophys J - published February 1, 2023
2. Dandan MT, Fraser JS
Dynamic association of an assembly platform subcomplex of the bacterial type two secretion system.
1. Biophys J - published February 1, 2023
2. Dazzoni R, Francetic O, Nilges M, Bardiaux B, Izadi Pruneyre N
Complexes of charged disordered polyelectrolyte-like proteins: From thermodynamics to stuctural plasticity.
1. Biophys J - published February 1, 2023
2. Chowdhury A, Sottini A, Borgia A, Borgia MB, Ghosh S, Mitra S, Yang T, Galvanetto N, Eapen R, Łukijańczuk P, Zhu R, Nettels D, Kundagrami A, Schuler B
Idpconformergenerator: A flexible software suite for sampling the conformational space of disordered protein states.
1. Biophys J - published February 1, 2023
2. Teixeira JMC, Hao Liu Z, Namini A, Li J, Vernon RM, Krzeminski M, Shamandy AA, Zhang O, Haghighatlari M, Yu L, Head-Gordon TL, Forman-Kay JD
Structural studies of RB69 polymerase-DNA complex.
1. Biophys J - published February 1, 2023
2. Kang W, Zeng X, Ayhan M, Lodwick JE, Zhao M, Ren Z, Yang X
Near-physiological in vitro reconstitution of 50S subunit reveals parallel assembly pathway.
1. Biophys J - published February 1, 2023
2. Dong X, Doerfel L, Sheng K, Rabuck-Gibbons JN, Popova A, Lyumkis D, Williamson JR
A Fijivirus Major Viroplasm Protein Shows RNA-Stimulated ATPase Activity by Adopting Pentameric and Hexameric Assemblies of Dimers.
1. mBio - published February 1, 2023
2. Llauger G, Melero R, Monti D, Sycz G, Huck-Iriart C, Cerutti ML, Klinke S, Mikkelsen E, Tijman A, Arranz R, Alfonso V, Arellano SM, Goldbaum FA, Sterckx YGJ, Carazo JM, Kaufman SB, Dans PD, Del Vas M, Otero LH
Enabling multiperspective single-molecule FRET.
1. Biophys J - published February 1, 2023
2. Kiselev R, Modak A, Terry D, Borgia A, Altman R, Blanchard SC
The factors that determine the force needed to unfold a membrane protein in silico depend on the pulling direction.
1. Biophys J - published February 1, 2023
2. Faruk NF, Peng X, Sosnick TR
Insights into the mechanism of the bacterial, periplasm-spanning transporter system 'Ton'.
1. Biophys J - published February 1, 2023
2. Zinke MC, Lejeune M, Bardiaux B, Nilges M, Izadi Pruneyre N
Control of bacterial immune signaling by a WYL domain transcription factor.
1. Biophys J - published February 1, 2023
2. Blankenchip C, Nguyen J, Lau R, Ye Q, Gu Y, Corbett KD
Structure and activity of a bacterial defense-associated 3'-5' exonuclease.
1. Biophys J - published February 1, 2023
2. Liang Q, Richey ST, Blankenchip C, Ur SN, Ye Q, Lau RK, Corbett KD
Stabilized SARS-CoV-2 spike S2 immunogens designed using insights from enhanced sampling molecular dynamics simulations.
1. Biophys J - published February 1, 2023
2. Nuqui X, Casalino L, Shehata M, Ojha AA, Kearns FL, Rosenfeld M, McLellan JS, Amaro RE
Investigating the mechanism of interaction of R-loops and the Fragile X protein, FMRP: An entanglement of disordered tails and multivalency.
1. Biophys J - published February 1, 2023
2. Li J, Garcia Dettori L, Landry S, Guerrero A, Chakraborty A, Feng W, Bah A
Kinesin-1, -2 and -3 use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport.
1. Biophys J - published February 1, 2023
2. Gicking AM, Ma TC, Feng Q, Jiang R, Badieyan S, Cianfrocco MA, Hancock WO
Principles of mitoribosomal small subunit assembly in eukaryotes.
1. Biophys J - published February 1, 2023
2. Burnside CL, Harper N, Klinge S
Unsupervised voxel-based segmentation reveals landscape of bacterial ribosome large subunit early assembly.
1. Biophys J - published February 1, 2023
2. Sheng K, Li N, Rabuck-Gibbons JN, Dong X, Lyumkis D, Williamson JR
Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice.
1. NPJ Vaccines - published February 1, 2023
2. Nanishi E, Borriello F, Seo HS, O'Meara TR, McGrath ME, Saito Y, Chen J, Diray-Arce J, Song K, Xu AZ, Barman S, Menon M, Dong D, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Baden LR, Ernst RK, Dillen C, Yu J, Chang A, Hilgers L, Platenburg PP, Dhe-Paganon S, Barouch DH, Ozonoff A, Zanoni I, Frieman MB, Dowling DJ, Levy O
High-throughput screening to identify modulators of membrane protein raft affinity in giant plasma membrane vesicles.
1. Biophys J - published February 1, 2023
2. Stefanski KM, Bauer J, Kenworthy AK, Sanders CR
Phosphorylation refines the control of complex formation in IDPs.
1. Biophys J - published February 1, 2023
2. McIvor JAP, Buholzer K, Zosel F, Teppich C, Nettels D, Schuler B, Mercadante D
Towards an atomistic model of the vertebrate inner-ear transduction apparatus.
1. Biophys J - published February 1, 2023
2. Sotomayor M
Electrostatics of salt-dependent re-entrant phase behaviors highlights diverse roles of ATP in biomolecular condensates.
1. Biophys J - published February 1, 2023
2. Lin YH, Hun Kim T, Das S, Pal T, Wessen J, Kay LE, Forman-Kay JD, Sun Chan H
Structure refinement of transmembrane domain of KCNE3 in proteoliposomes using EPR spectroscopy.
1. Biophys J - published February 1, 2023
2. Sahu ID, Scheyer M, Campbell C, Williams PL, Asare IK, Begum A, Hussain M, Sanders CR, Lorigan GA
Exploring the structure and function of the peptidase-ABC transporter fusion protein ZmaM.
1. Biophys J - published February 1, 2023
2. Zavala GE, Velilla JA, Patel M, Walsh RM, Gaudet R
Cryo-EM structures of the TolQ membrane protein in complex with inner membrane protein partner TolR from the opportunistic pathogen Acinetobacter baumannii provide information on structure and stoichiometry.
1. Biophys J - published February 1, 2023
2. Karimullina E, Guo Y, Quade B, Di Leo R, Otwinowski Z, Borek D, Savchenko A
State-specific morphological deformations of the lipid bilayer explain mechanosensitive gating of MSCs ion channels.
1. Biophys J - published February 1, 2023
2. Park YC, Reddy B, Bavi N, Perozo E, Faraldo-Gómez JD
Folding stability at the anion-binding site distinguishes prestin from other SLC26 transporters as revealed by HDX-MS.
1. Biophys J - published February 1, 2023
2. Lin X, Haller PR, Bavi N, Faruk N, Perozo E, Sosnick TR
Structural basis of rapid inactivation of HERG potassium channels.
1. Biophys J - published February 1, 2023
2. Lau C, Flood E, Hunter M, Corbett K, Ng C, Bouwer J, Stewart A, Perozo E, Allen TW, Vandenberg J
Nonlinear compliance of NOMPC gating spring and its implication in mechanotransduction.
1. Biophys J - published February 1, 2023
2. Wang Y, Jin P, Kumar A, Bulkley D, Jan LY, Cheng Y, Jan YN, Zhang Y
Mapping the determinants of substrate selectivity in a bacterial metal transporter with model-guided deep mutagenesis.
1. Biophys J - published February 1, 2023
2. Berry SP, Freedman CB, Marks DS, Gaudet R
Structural basis for CorA channel gating using conformation-specific synthetic antigen binders and single-particle cryo-EM.
1. Biophys J - published February 1, 2023
2. Erramilli SK, Dominik PK, Li T, Nosol K, Tokarz P, Dutka P, Zhao M, Perozo E, Kossiakoff AA
Kinesin-1 utilizes a hierarchical folding mechanism to promote autoinhibition.
1. Biophys J - published February 1, 2023
2. Tan Z, Haynes S, Yang Y, Leprevost F, Nesvizhskii A, Verhey K, Cianfrocco MA
Structure and dynamics of the essential endogenous mycobacterial polyketide synthase PKs13 by cryogenic electron microscopy.
1. Biophys J - published February 1, 2023
2. Stroud RM, Kyung Kim S, Dickinson MSS, Rosenberg OS
A cellular metabolite directly and reversibly opens the ATP release pannexin channels.
1. Biophys J - published February 1, 2023
2. Henze EK, Kawate T
3D reconstruction shows mouse skeletal muscle may decline in function across aging due to the MICOS complex.
1. Biophys J - published February 1, 2023
2. Neikirk K, Vue Z, Garza-Lopez E, Vang L, Crabtree A, Beasley H, Marshall A, Damo S, Hinton AO
Conformational dynamics control assembly of an extremely long bacteriophage tail tube.
1. J Biol Chem - published February 1, 2023
2. Agnello E, Pajak J, Liu X, Kelch BA
A NPAS4-NuA4 complex couples synaptic activity to DNA repair.
1. Nature - published February 1, 2023
2. Pollina EA, Gilliam DT, Landau AT, Lin C, Pajarillo N, Davis CP, Harmin DA, Yap EL, Vogel IR, Griffith EC, Nagy MA, Ling E, Duffy EE, Sabatini BL, Weitz CJ, Greenberg ME
Chemoproteomic discovery of a human RNA ligase.
1. Nat Commun - published February 1, 2023
2. Yuan Y, Stumpf FM, Schlor LA, Schmidt OP, Saumer P, Huber LB, Frese M, Höllmüller E, Scheffner M, Stengel F, Diederichs K, Marx A
Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes.
1. Immunity - published February 1, 2023
2. Fabra-García A, Hailemariam S, de Jong RM, Janssen K, Teelen K, van de Vegte-Bolmer M, van Gemert GJ, Ivanochko D, Semesi A, McLeod B, Vos MW, de Bruijni MHC, Bolscher JM, Szabat M, Vogt S, Kraft L, Duncan S, Kamya MR, Feeney ME, Jagannathan P, Greenhouse B, Dechering KJ, Sauerwein RW, King CR, MacGill RS, Bousema T, Julien JP, Jore MM
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230.
1. Immunity - published February 1, 2023
2. Ivanochko D, Fabra-García A, Teelen K, van de Vegte-Bolmer M, van Gemert GJ, Newton J, Semesi A, de Bruijni M, Bolscher J, Ramjith J, Szabat M, Vogt S, Kraft L, Duncan S, Lee SM, Kamya MR, Feeney ME, Jagannathan P, Greenhouse B, Sauerwein RW, Richter King C, MacGill RS, Bousema T, Jore MM, Julien JP
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine.
1. Immunity - published February 1, 2023
2. Tang WK, Coelho CH, Miura K, Nguemwo Tentokam BC, Salinas ND, Narum DL, Healy SA, Sagara I, Long CA, Duffy PE, Tolia NH
Characterization of visual processing in temporomandibular disorders using functional magnetic resonance imaging.
1. Brain Behav - published February 1, 2023
2. Harper DE, Gopinath K, Smith JL, Gregory M, Ichesco E, Aronovich S, Harris RE, Harte SE, Clauw DJ, Fleischer CC
Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis.
1. Nucleic Acids Res - published February 1, 2023
2. Garg A, Sanchez AM, Miele M, Schwer B, Shuman S
Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity.
1. ACS Chem Biol - published February 1, 2023
2. Quek RT, Hardy KS, Walker SG, Nguyen DT, de Almeida Magalhães T, Salic A, Gopalakrishnan SM, Silver PA, Mitchison TJ
Diversity, distribution, and expression of opsin genes in freshwater lakes.
1. Mol Ecol - published February 1, 2023
2. He S, Linz AM, Stevens SLR, Tran PQ, Moya-Flores F, Oyserman BO, Dwulit-Smith JR, Forest KT, McMahon KD
Structure and function of prodrug-activating peptidases.
1. Biochimie - published February 1, 2023
2. Velilla JA, Kenney GE, Gaudet R
RTEL1 and MCM10 overcome topological stress during vertebrate replication termination.
1. Cell Rep - published February 1, 2023
2. Campos LV, Van Ravenstein SX, Vontalge EJ, Greer BH, Heintzman DR, Kavlashvili T, McDonald WH, Rose KL, Eichman BF, Dewar JM
The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice.
1. Nat Commun - published February 1, 2023
2. Nieweglowska ES, Brilot AF, Méndez-Moran M, Kokontis C, Baek M, Li J, Cheng Y, Baker D, Bondy-Denomy J, Agard DA
Structural snapshots of R-loop formation by a type I-C CRISPR Cascade.
1. Mol Cell - published February 1, 2023
2. O'Brien RE, Bravo JPK, Ramos D, Hibshman GN, Wright JT, Taylor DW
Design of a stabilized non-glycosylated Pfs48/45 antigen enables a potent malaria transmission-blocking nanoparticle vaccine.
1. NPJ Vaccines - published February 1, 2023
2. Dickey TH, Gupta R, McAleese H, Ouahes T, Orr-Gonzalez S, Ma R, Muratova O, Salinas ND, Hume JCC, Lambert LE, Duffy PE, Tolia NH
Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C. elegans.
1. Immunity - published February 1, 2023
2. Peterson ND, Tse SY, Huang QJ, Wani KA, Schiffer CA, Pukkila-Worley R
Redox Regulation of m (6) A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes.
1. bioRxiv - published February 1, 2023
2. De Jesus DF, Zhang Z, Brown NK, Li X, Gaffrey MJ, Kahraman S, Wei J, Hu J, Basile G, Xiao L, Rana TM, Mathews C, Powers AC, Atkinson MA, Eizirik DL, Dhe-Paganon S, Parent AV, Qian WJ, He C, Kulkarni RN
Effect of Grain Size on the Tribological Behavior of CoCrFeMnNi High Entropy Alloy.
1. Materials (Basel) - published February 1, 2023
2. Wang Y, Li D, Yang J, Jin J, Zhang M, Wang X, Li B, Hu Z, Gong P
Grinding Force and Surface Formation Mechanisms of 17CrNi2MoVNb Alloy When Grinding with CBN and Alumina Wheels.
1. Materials (Basel) - published February 1, 2023
2. Jiang X, Liu K, Si M, Li M, Gong P
TcpA from the Clostridiumperfringens plasmid pCW3 is more closely related to the DNA translocase FtsK than to coupling proteins.
1. Structure - published February 1, 2023
2. Traore DAK, Torres VVL, Akhtar N, Gummer AM, Flanigan SF, Coulibaly F, Adams V, Whisstock JC, Rood JI
COVID-19 Vaccination: Comparison of Attitudes, Decision-Making Processes, and Communication among Vaccinated and Unvaccinated Black Americans.
1. Int J Environ Res Public Health - published February 1, 2023
2. Cunningham-Erves J, George W, Stewart EC, Footman A, Davis J, Sanderson M, Smalls M, Morris P, Clarkson K, Lee O, Brandt HM
Gene Editing of Primary Rhesus Macaque B Cells.
1. J Vis Exp - published February 1, 2023
2. Hartweger H, Gautam R, Nishimura Y, Schmidt F, Yao KH, Escolano A, Jankovic M, Martin MA, Nussenzweig MC
Cell-free reconstitution of peroxisomal matrix protein import using Xenopus egg extract.
1. STAR Protoc - published February 1, 2023
2. Skowyra ML, Rapoport TA
Global Trends of Prostate Cancer by Age, and Their Associations With Gross Domestic Product (GDP), Human Development Index (HDI), Smoking, and Alcohol Drinking.
1. Clin Genitourin Cancer - published February 1, 2023
2. Huang J, Chan EO, Liu X, Lok V, Ngai CH, Zhang L, Xu W, Zheng ZJ, Chiu PK, Vasdev N, Enikeev D, Shariat SF, Ng CF, Teoh JY, Wong MCS
Multi-Institutional Study of Pathologist Reading of the Programmed Cell Death Ligand-1 Combined Positive Score Immunohistochemistry Assay for Gastric or Gastroesophageal Junction Cancer.
1. Mod Pathol - published February 1, 2023
2. Fernandez AI, Robbins CJ, Gaule P, Agostini-Vulaj D, Anders RA, Bellizi A, Chen W, Chen ZE, Gopal P, Zhao L, Lisovsky M, Liu X, Shia J, Wang H, Yang Z, McCann L, Chan YG, Weidler J, Bates M, Zhang X, Rimm DL