Member Publications

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106 Member Publications for April 2022

X-ray crystal structure of the Escherichia coli RadD DNA repair protein bound to ADP reveals a novel zinc ribbon domain.
1. PLoS One - published April 28, 2022
2. Osorio Garcia MA, Satyshur KA, Cox MM, Keck JL
Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity.
1. Elife - published April 21, 2022
2. Heo Y, Yoon E, Jeon YE, Yun JH, Ishimoto N, Woo H, Park SY, Song JJ, Lee W
Targeting Multidrug Resistance With Antimicrobial Peptide-Decorated Nanoparticles and Polymers.
1. Front Microbiol - published April 18, 2022
2. Maleki Dizaj S, Salatin S, Khezri K, Lee JY, Lotfipour F
Predictive model for the intraoperative unresectability of hilar cholangiocarcinoma: Reducing futile surgical exploration.
1. PLoS One - published April 13, 2022
2. Song J, Lei X, Lin H, Dai H, Liu X, Jiang Y, Hu F, Li Y, Fan H, Zhang L, Chen Z, Zhang C
Serological testing for SARS-CoV-2 antibodies of employees shows low transmission working in a cancer center.
1. PLoS One - published April 12, 2022
2. Meyerhardt JA, Yue H, Nowak RP, Brais L, Ma C, Johnson S, Harrod J, Burman SSR, Hendrickson LM, Fischinger S, Alter G, Hahn W, Johnson BE, Fischer ES
Autophagy-Related Signatures as Prognostic Indicators for Hepatocellular Carcinoma.
1. Front Oncol - published April 11, 2022
2. Ye W, Shi Z, Zhou Y, Zhang Z, Zhou Y, Chen B, Zhang Q
Tuning T cell receptor sensitivity through catch bond engineering.
1. Science - published April 8, 2022
2. Zhao X, Kolawole EM, Chan W, Feng Y, Yang X, Gee MH, Jude KM, Sibener LV, Fordyce PM, Germain RN, Evavold BD, Garcia KC
Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.
1. Nature - published April 8, 2022
2. Hobbs SJ, Wein T, Lu A, Morehouse BR, Schnabel J, Leavitt A, Yirmiya E, Sorek R, Kranzusch PJ
Mapping genomic loci implicates genes and synaptic biology in schizophrenia.
1. Nature - published April 8, 2022
2. Trubetskoy V, Pardiñas AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, Bryois J, Chen CY, Dennison CA, Hall LS, Lam M, Watanabe K, Frei O, Ge T, Harwood JC, Koopmans F, Magnusson S, Richards AL, Sidorenko J, Wu Y, Zeng J, Grove J, Kim M, Li Z, Voloudakis G, Zhang W, Adams M, Agartz I, Atkinson EG, Agerbo E, Al Eissa M, Albus M, Alexander M, Alizadeh BZ, Alptekin K, Als TD, Amin F, Arolt V, Arrojo M, Athanasiu L, Azevedo MH, Bacanu SA, Bass NJ, Begemann M, Belliveau RA, Bene J, Benyamin B, Bergen SE, Blasi G, Bobes J, Bonassi S, Braun A, Bressan RA, Bromet EJ, Bruggeman R, Buckley PF, Buckner RL, Bybjerg-Grauholm J, Cahn W, Cairns MJ, Calkins ME, Carr VJ, Castle D, Catts SV, Chambert KD, Chan RCK, Chaumette B, Cheng W, Cheung EFC, Chong SA, Cohen D, Consoli A, Cordeiro Q, Costas J, Curtis C, Davidson M, Davis KL, de Haan L, Degenhardt F, DeLisi LE, Demontis D, Dickerson F, Dikeos D, Dinan T, Djurovic S, Duan J, Ducci G, Dudbridge F, Eriksson JG, Fañanás L, Faraone SV, Fiorentino A, Forstner A, Frank J, Freimer NB, Fromer M, Frustaci A, Gadelha A, Genovese G, Gershon ES, Giannitelli M, Giegling I, Giusti-Rodríguez P, Godard S, Goldstein JI, González Peñas J, González-Pinto A, Gopal S, Gratten J, Green MF, Greenwood TA, Guillin O, Gülöksüz S, Gur RE, Gur RC, Gutiérrez B, Hahn E, Hakonarson H, Haroutunian V, Hartmann AM, Harvey C, Hayward C, Henskens FA, Herms S, Hoffmann P, Howrigan DP, Ikeda M, Iyegbe C, Joa I, Julià A, Kähler AK, Kam-Thong T, Kamatani Y, Karachanak-Yankova S, Kebir O, Keller MC, Kelly BJ, Khrunin A, Kim SW, Klovins J, Kondratiev N, Konte B, Kraft J, Kubo M, Kučinskas V, Kučinskiene ZA, Kusumawardhani A, Kuzelova-Ptackova H, Landi S, Lazzeroni LC, Lee PH, Legge SE, Lehrer DS, Lencer R, Lerer B, Li M, Lieberman J, Light GA, Limborska S, Liu CM, Lönnqvist J, Loughland CM, Lubinski J, Luykx JJ, Lynham A, Macek M Jr, Mackinnon A, Magnusson PKE, Maher BS, Maier W, Malaspina D, Mallet J, Marder SR, Marsal S, Martin AR, Martorell L, Mattheisen M, McCarley RW, McDonald C, McGrath JJ, Medeiros H, Meier S, Melegh B, Melle I, Mesholam-Gately RI, Metspalu A, Michie PT, Milani L, Milanova V, Mitjans M, Molden E, Molina E, Molto MD, Mondelli V, Moreno C, Morley CP, Muntané G, Murphy KC, Myin-Germeys I, Nenadić I, Nestadt G, Nikitina-Zake L, Noto C, Nuechterlein KH, O'Brien NL, O'Neill FA, Oh SY, Olincy A, Ota VK, Pantelis C, Papadimitriou GN, Parellada M, Paunio T, Pellegrino R, Periyasamy S, Perkins DO, Pfuhlmann B, Pietiläinen O, Pimm J, Porteous D, Powell J, Quattrone D, Quested D, Radant AD, Rampino A, Rapaport MH, Rautanen A, Reichenberg A, Roe C, Roffman JL, Roth J, Rothermundt M, Rutten BPF, Saker-Delye S, Salomaa V, Sanjuan J, Santoro ML, Savitz A, Schall U, Scott RJ, Seidman LJ, Sharp SI, Shi J, Siever LJ, Sigurdsson E, Sim K, Skarabis N, Slominsky P, So HC, Sobell JL, Söderman E, Stain HJ, Steen NE, Steixner-Kumar AA, Stögmann E, Stone WS, Straub RE, Streit F, Strengman E, Stroup TS, Subramaniam M, Sugar CA, Suvisaari J, Svrakic DM, Swerdlow NR, Szatkiewicz JP, Ta TMT, Takahashi A, Terao C, Thibaut F, Toncheva D, Tooney PA, Torretta S, Tosato S, Tura GB, Turetsky BI, Üçok A, Vaaler A, van Amelsvoort T, van Winkel R, Veijola J, Waddington J, Walter H, Waterreus A, Webb BT, Weiser M, Williams NM, Witt SH, Wormley BK, Wu JQ, Xu Z, Yolken R, Zai CC, Zhou W, Zhu F, Zimprich F, Atbaşoğlu EC, Ayub M, Benner C, Bertolino A, Black DW, Bray NJ, Breen G, Buccola NG, Byerley WF, Chen WJ, Cloninger CR, Crespo-Facorro B, Donohoe G, Freedman R, Galletly C, Gandal MJ, Gennarelli M, Hougaard DM, Hwu HG, Jablensky AV, McCarroll SA, Moran JL, Mors O, Mortensen PB, Müller-Myhsok B, Neil AL, Nordentoft M, Pato MT, Petryshen TL, Pirinen M, Pulver AE, Schulze TG, Silverman JM, Smoller JW, Stahl EA, Tsuang DW, Vilella E, Wang SH, Xu S, Indonesia Schizophrenia Consortium., PsychENCODE., Psychosis Endophenotypes International Consortium., SynGO Consortium., Adolfsson R, Arango C, Baune BT, Belangero SI, Børglum AD, Braff D, Bramon E, Buxbaum JD, Campion D, Cervilla JA, Cichon S, Collier DA, Corvin A, Curtis D, Forti MD, Domenici E, Ehrenreich H, Escott-Price V, Esko T, Fanous AH, Gareeva A, Gawlik M, Gejman PV, Gill M, Glatt SJ, Golimbet V, Hong KS, Hultman CM, Hyman SE, Iwata N, Jönsson EG, Kahn RS, Kennedy JL, Khusnutdinova E, Kirov G, Knowles JA, Krebs MO, Laurent-Levinson C, Lee J, Lencz T, Levinson DF, Li QS, Liu J, Malhotra AK, Malhotra D, McIntosh A, McQuillin A, Menezes PR, Morgan VA, Morris DW, Mowry BJ, Murray RM, Nimgaonkar V, Nöthen MM, Ophoff RA, Paciga SA, Palotie A, Pato CN, Qin S, Rietschel M, Riley BP, Rivera M, Rujescu D, Saka MC, Sanders AR, Schwab SG, Serretti A, Sham PC, Shi Y, St Clair D, Stefánsson H, Stefansson K, Tsuang MT, van Os J, Vawter MP, Weinberger DR, Werge T, Wildenauer DB, Yu X, Yue W, Holmans PA, Pocklington AJ, Roussos P, Vassos E, Verhage M, Visscher PM, Yang J, Posthuma D, Andreassen OA, Kendler KS, Owen MJ, Wray NR, Daly MJ, Huang H, Neale BM, Sullivan PF, Ripke S, Walters JTR, O'Donovan MC, Schizophrenia Working Group of the Psychiatric Genomics Consortium.
Variation of Antigen 43 self-association modulates bacterial compacting within aggregates and biofilms.
1. NPJ Biofilms Microbiomes - published April 8, 2022
2. Vo JL, Ortiz GCM, Totsika M, Lo AW, Hancock SJ, Whitten AE, Hor L, Peters KM, Ageorges V, Caccia N, Desvaux M, Schembri MA, Paxman JJ, Heras B
Fighting SARS-CoV-2 with structural biology methods.
1. Nat Methods - published April 8, 2022
2. Zhang J, Chen B
Development of monoclonal antibodies to detect for SARS-CoV-2 proteins.
1. J Mol Biol - published April 8, 2022
2. Mishra N, Teyra J, Boytz R, Miersch S, Merritt TN, Cardarelli L, Gorelik M, Mihalic F, Jemth P, Davey R, Sidhu SS, Leung DW, Amarasinghe GK
Quantitative mining of compositional heterogeneity in cryo-EM datasets of ribosome assembly intermediates.
1. Structure - published April 7, 2022
2. Rabuck-Gibbons JN, Lyumkis D, Williamson JR
Analysis of Viral Spike Protein N-Glycosylation Using Ultraviolet Photodissociation Mass Spectrometry.
1. Anal Chem - published April 7, 2022
2. Escobar EE, Wang S, Goswami R, Lanzillotti MB, Li L, McLellan JS, Brodbelt JS
Germline variants in tumor suppressor FBXW7 lead to impaired ubiquitination and a neurodevelopmental syndrome.
1. Am J Hum Genet - published April 7, 2022
2. Stephenson SEM, Costain G, Blok LER, Silk MA, Nguyen TB, Dong X, Alhuzaimi DE, Dowling JJ, Walker S, Amburgey K, Hayeems RZ, Rodan LH, Schwartz MA, Picker J, Lynch SA, Gupta A, Rasmussen KJ, Schimmenti LA, Klee EW, Niu Z, Agre KE, Chilton I, Chung WK, Revah-Politi A, Au PYB, Griffith C, Racobaldo M, Raas-Rothschild A, Ben Zeev B, Barel O, Moutton S, Morice-Picard F, Carmignac V, Cornaton J, Marle N, Devinsky O, Stimach C, Wechsler SB, Hainline BE, Sapp K, Willems M, Bruel AL, Dias KR, Evans CA, Roscioli T, Sachdev R, Temple SEL, Zhu Y, Baker JJ, Scheffer IE, Gardiner FJ, Schneider AL, Muir AM, Mefford HC, Crunk A, Heise EM, Millan F, Monaghan KG, Person R, Rhodes L, Richards S, Wentzensen IM, Cogné B, Isidor B, Nizon M, Vincent M, Besnard T, Piton A, Marcelis C, Kato K, Koyama N, Ogi T, Goh ES, Richmond C, Amor DJ, Boyce JO, Morgan AT, Hildebrand MS, Kaspi A, Bahlo M, Friðriksdóttir R, Katrínardóttir H, Sulem P, Stefánsson K, Björnsson HT, Mandelstam S, Morleo M, Mariani M, TUDP Study Group., Scala M, Accogli A, Torella A, Capra V, Wallis M, Jansen S, Weisfisz Q, de Haan H, Sadedin S, Broad Center for Mendelian Genomics., Lim SC, White SM, Ascher DB, Schenck A, Lockhart PJ, Christodoulou J, Tan TY
The molecular basis of spinocerebellar ataxia type 48 caused by a de novo mutation in the ubiquitin ligase CHIP.
1. J Biol Chem - published April 7, 2022
2. Umano A, Fang K, Qu Z, Scaglione JB, Altinok S, Treadway CJ, Wick ET, Paulakonis E, Karunanayake C, Chou S, Bardakjian TM, Gonzalez-Alegre P, Page RC, Schisler JC, Brown NG, Yan D, Scaglione KM
Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation.
1. Mol Cell - published April 7, 2022
2. Gao X, Liu Y, Li Y, Fan H, Wu R, Zhang R, Faubert B, He YY, Bissonnette MB, Xia S, Chen D, Mao H, Boggon TJ, Chen J
Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins.
1. Immunity - published April 7, 2022
2. Wang Z, Muecksch F, Cho A, Gaebler C, Hoffmann HH, Ramos V, Zong S, Cipolla M, Johnson B, Schmidt F, DaSilva J, Bednarski E, Ben Tanfous T, Raspe R, Yao K, Lee YE, Chen T, Turroja M, Milard KG, Dizon J, Kaczynska A, Gazumyan A, Oliveira TY, Rice CM, Caskey M, Bieniasz PD, Hatziioannou T, Barnes CO, Nussenzweig MC
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation.
1. Nature - published April 6, 2022
2. Junqueira C, Crespo Â, Ranjbar S, de Lacerda LB, Lewandrowski M, Ingber J, Parry B, Ravid S, Clark S, Schrimpf MR, Ho F, Beakes C, Margolin J, Russell N, Kays K, Boucau J, Das Adhikari U, Vora SM, Leger V, Gehrke L, Henderson L, Janssen E, Kwon D, Sander C, Abraham J, Goldberg MB, Wu H, Mehta G, Bell S, Goldfeld AE, Filbin MR, Lieberman J
AMIGOS III: Pseudo-torsion angle visualization and motif-based structure comparison of nucleic acids.
1. Bioinformatics - published April 6, 2022
2. Shine M, Zhang C, Pyle AM
Panel of Engineered Ubiquitin Variants Targeting the Family of Human Ubiquitin Interacting Motifs.
1. ACS Chem Biol - published April 6, 2022
2. Veggiani G, Yates BP, Martyn GD, Manczyk N, Singer AU, Kurinov I, Sicheri F, Sidhu SS
Structure-based Evolution of G protein-biased μ-opioid Receptor Agonists.
1. Angew Chem Int Ed Engl - published April 6, 2022
2. Gmeiner P, Wang H, Hetzer F, Huang W, Qu Q, Meyerowitz J, Kaindl J, Hübner H, Skiniotis G, Kobilka BK
Eye tracking: empirical foundations for a minimal reporting guideline.
1. Behav Res Methods - published April 6, 2022
2. Holmqvist K, Örbom SL, Hooge ITC, Niehorster DC, Alexander RG, Andersson R, Benjamins JS, Blignaut P, Brouwer AM, Chuang LL, Dalrymple KA, Drieghe D, Dunn MJ, Ettinger U, Fiedler S, Foulsham T, van der Geest JN, Hansen DW, Hutton SB, Kasneci E, Kingstone A, Knox PC, Kok EM, Lee H, Lee JY, Leppänen JM, Macknik S, Majaranta P, Martinez-Conde S, Nuthmann A, Nyström M, Orquin JL, Otero-Millan J, Park SY, Popelka S, Proudlock F, Renkewitz F, Roorda A, Schulte-Mecklenbeck M, Sharif B, Shic F, Shovman M, Thomas MG, Venrooij W, Zemblys R, Hessels RS
Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile.
1. Nature - published April 6, 2022
2. Cao X, Boyaci H, Chen J, Bao Y, Landick R, Campbell EA
An allosteric HTRA1-calpain 2 complex with restricted activation profile.
1. Proc Natl Acad Sci U S A - published April 5, 2022
2. Rey J, Breiden M, Lux V, Bluemke A, Steindel M, Ripkens K, Möllers B, Bravo Rodriguez K, Boisguerin P, Volkmer R, Mieres-Perez J, Clausen T, Sanchez-Garcia E, Ehrmann M
The solute carrier SLC15A4 is required for optimal trafficking of nucleic acid-sensing TLRs and ligands to endolysosomes.
1. Proc Natl Acad Sci U S A - published April 5, 2022
2. Rimann I, Gonzalez-Quintial R, Baccala R, Kiosses WB, Teijaro JR, Parker CG, Li X, Beutler B, Kono DH, Theofilopoulos AN
Listeria monocytogenes requires cellular respiration for NAD⁺ regeneration and pathogenesis.
1. Elife - published April 5, 2022
2. Rivera-Lugo R, Deng D, Anaya-Sanchez A, Tejedor-Sanz S, Tang E, Reyes Ruiz VM, Smith HB, Titov DV, Sauer JD, Skaar EP, Ajo-Franklin CM, Portnoy DA, Light SH
Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.
1. Nat Commun - published April 5, 2022
2. Liang WG, Wijaya J, Wei H, Noble AJ, Mancl JM, Mo S, Lee D, Lin King JV, Pan M, Liu C, Koehler CM, Zhao M, Potter CS, Carragher B, Li S, Tang WJ
Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation.
1. Nat Commun - published April 5, 2022
2. Botte M, Ni D, Schenck S, Zimmermann I, Chami M, Bocquet N, Egloff P, Bucher D, Trabuco M, Cheng RKY, Brunner JD, Seeger MA, Stahlberg H, Hennig M
Affinity requirements for control of synaptic targeting and neuronal cell survival by heterophilic IgSF cell adhesion molecules.
1. Cell Rep - published April 5, 2022
2. Xu S, Sergeeva AP, Katsamba PS, Mannepalli S, Bahna F, Bimela J, Zipursky SL, Shapiro L, Honig B, Zinn K
Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge.
1. J Exp Med - published April 4, 2022
2. Kafai NM, Williamson LE, Binshtein E, Sukupolvi-Petty S, Gardner CL, Liu J, Mackin S, Kim AS, Kose N, Carnahan RH, Jung A, Droit L, Reed DS, Handley SA, Klimstra WB, Crowe JE, Diamond MS
Towards depeptidized aminoboronic acid derivatives through the use of borylated iminium ions.
1. Chem Commun (Camb) - published April 4, 2022
2. Trudel V, Brien C, Tan J, Yudin AK
Hydration for Clean Air Today^a.
1. Mol Front J - published April 4, 2022
2. Edwards DA, Norden B, Karnath L, Yaghi O, Roy CJ, Johanson D, Ott M, Brownstein J, Grove J, Tomson G, Friberg P
Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus.
1. Nat Neurosci - published April 4, 2022
2. Duy PQ, Weise SC, Marini C, Li XJ, Liang D, Dahl PJ, Ma S, Spajic A, Dong W, Juusola J, Kiziltug E, Kundishora AJ, Koundal S, Pedram MZ, Torres-Fernández LA, Händler K, De Domenico E, Becker M, Ulas T, Juranek SA, Cuevas E, Hao LT, Jux B, Sousa AMM, Liu F, Kim SK, Li M, Yang Y, Takeo Y, Duque A, Nelson-Williams C, Ha Y, Selvaganesan K, Robert SM, Singh AK, Allington G, Furey CG, Timberlake AT, Reeves BC, Smith H, Dunbar A, DeSpenza T Jr, Goto J, Marlier A, Moreno-De-Luca A, Yu X, Butler WE, Carter BS, Lake EMR, Constable RT, Rakic P, Lin H, Deniz E, Benveniste H, Malvankar NS, Estrada-Veras JI, Walsh CA, Alper SL, Schultze JL, Paeschke K, Doetzlhofer A, Wulczyn FG, Jin SC, Lifton RP, Sestan N, Kolanus W, Kahle KT
Regulators of cell volume: The structural and functional properties of anion channels of the LRRC8 family.
1. Curr Opin Struct Biol - published April 3, 2022
2. Sawicka M, Dutzler R
Fabrication of Titanium and Copper-Coated Diamond/Copper Composites via Selective Laser Melting.
1. Micromachines (Basel) - published April 3, 2022
2. Zhang L, Li Y, Li S, Gong P, Chen Q, Geng H, Sun M, Sun Q, Hao L
Clinical Phenotypes and Outcomes in Monogenic versus Non-Monogenic Very Early Onset Inflammatory Bowel Disease.
1. J Crohns Colitis - published April 2, 2022
2. Collen LV, Kim DY, Field M, Okoroafor I, Saccocia G, Whitcomb SD, Green J, Dong MD, Barends J, Carey B, Weatherly ME, Center RG, Rockowitz S, Sliz P, Liu E, Eran A, Grushkin-Lerner L, Bousvaros A, Muise AM, Klein C, Mitsialis V, Ouahed J, Snapper SB
Mechanistic insight into light-dependent recognition of Timeless by Drosophila Cryptochrome.
1. Structure - published April 2, 2022
2. Lin C, Schneps CM, Chandrasekaran S, Ganguly A, Crane BR
Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants.
1. Cell - published April 2, 2022
2. Servellita V, Syed AM, Morris MK, Brazer N, Saldhi P, Garcia-Knight M, Sreekumar B, Khalid MM, Ciling A, Chen PY, Kumar GR, Gliwa AS, Nguyen J, Sotomayor-Gonzalez A, Zhang Y, Frias E, Prostko J, Hackett J Jr, Andino R, Wadford DA, Hanson C, Doudna J, Ott M, Chiu CY
Predicting the functional impact of KCNQ1 variants with artificial neural networks.
1. PLoS Comput Biol - published April 2, 2022
2. Phul S, Kuenze G, Vanoye CG, Sanders CR, George AL Jr, Meiler J
Author Correction: A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus.
1. Nat Med - published April 2, 2022
2. August A, Attarwala HZ, Himansu S, Kalidindi S, Lu S, Pajon R, Han S, Lecerf JM, Tomassini JE, Hard M, Ptaszek LM, Crowe JE, Zaks T
PDBx/mmCIF Ecosystem: Foundational Semantic Tools for Structural Biology.
1. J Mol Biol - published April 2, 2022
2. Westbrook JD, Young JY, Shao C, Feng Z, Guranovic V, Lawson CL, Vallat B, Adams PD, Berrisford JM, Bricogne G, Diederichs K, Joosten RP, Keller P, Moriarty NW, Sobolev OV, Velankar S, Vonrhein C, Waterman DG, Kurisu G, Berman HM, Burley SK, Peisach E
The early days of structural biology at the Beijing Institute of Biophysics: In memory of Professor Zhengjiong Lin (1935-2022).
1. Protein Cell - published April 2, 2022
2. Wang JH
Structure of a Vaccine-Induced, Germline-Encoded Human Antibody Defines a Neutralizing Epitope on the SARS-CoV-2 Spike N-Terminal Domain.
1. mBio - published April 2, 2022
2. Altomare CG, Adelsberg DC, Carreno JM, Sapse IA, Amanat F, Ellebedy AH, Simon V, Krammer F, Bajic G
The AAA+ ATPase p97 as a novel parasite and tuberculosis drug target.
1. Trends Parasitol - published April 2, 2022
2. Kobakhidze G, Sethi A, Valimehr S, Ralph SA, Rouiller I
Identifying Heterozipper β-Sheet in Twisted Amyloid Aggregation.
1. Nano Lett - published April 2, 2022
2. Song Y, Dai B, Wang Y, Wang Y, Liu C, Gourdon P, Liu L, Wang K, Dong M
An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern.
1. Sci Immunol - published April 2, 2022
2. Du W, Hurdiss DL, Drabek D, Mykytyn AZ, Kaiser FK, González-Hernández M, Muñoz-Santos D, Lamers MM, van Haperen R, Li W, Drulyte I, Wang C, Sola I, Armando F, Beythien G, Ciurkiewicz M, Baumgärtner W, Guilfoyle K, Smits T, van der Lee J, van Kuppeveld FJM, van Amerongen G, Haagmans BL, Enjuanes L, Osterhaus ADME, Grosveld F, Bosch BJ
Leaks in the Pipeline: a Failure Analysis of Gram-Negative Antibiotic Development from 2010 to 2020.
1. Antimicrob Agents Chemother - published April 2, 2022
2. Prasad NK, Seiple IB, Cirz RT, Rosenberg OS
An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimer.
1. J Clin Invest - published April 2, 2022
2. Suryadevara N, Shiakolas AR, VanBlargan LA, Binshtein E, Chen RE, Case JB, Kramer KJ, Armstrong EC, Myers L, Trivette A, Gainza C, Nargi RS, Selverian CN, Davidson E, Doranz BJ, Diaz SM, Handal LS, Carnahan RH, Diamond MS, Georgiev IS, Crowe JE Jr
Asporin, an extracellular matrix protein, is a beneficial regulator of cardiac remodeling.
1. Matrix Biol - published April 2, 2022
2. Huang C, Sharma A, Thakur R, Rai D, Katiki M, Germano JF, Song Y, Singh S, Sin J, Sengstock D, Andres AM, Murali R, Mentzer RM Jr, Gottlieb RA, Piplani H
Author Correction: Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity.
1. Commun Biol - published April 2, 2022
2. Renn JP, Doritchamou JYA, Tentokam BCN, Morrison RD, Cowles MV, Burkhardt M, Ma R, Mahamar A, Attaher O, Diarra BS, Traore M, Dicko A, Tolia NH, Fried M, Duffy PE
Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition.
1. Sci Adv - published April 2, 2022
2. Shaban NM, Yan R, Shi K, Moraes SN, Cheng AZ, Carpenter MA, McLellan JS, Yu Z, Harris RS
Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways.
1. Cell Rep - published April 2, 2022
2. Wang L, Moreira EA, Kempf G, Miyake Y, Oliveira Esteves BI, Fahmi A, Schaefer JV, Dreier B, Yamauchi Y, Alves MP, Plückthun A, Matthias P
Reconstitution of surface lipoprotein translocation through the slam translocon.
1. Elife - published April 2, 2022
2. Huynh MS, Hooda Y, Li YR, Jagielnicki M, Lai CC, Moraes TF
GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision.
1. Cell - published April 2, 2022
2. Asher WB, Terry DS, Gregorio GGA, Kahsai AW, Borgia A, Xie B, Modak A, Zhu Y, Jang W, Govindaraju A, Huang LY, Inoue A, Lambert NA, Gurevich VV, Shi L, Lefkowitz RJ, Blanchard SC, Javitch JA
L-tyrosine-bound ThiH structure reveals C-C bond break differences within radical SAM aromatic amino acid lyases.
1. Nat Commun - published April 2, 2022
2. Amara P, Saragaglia C, Mouesca JM, Martin L, Nicolet Y
A cryptic pocket in Ebola VP35 allosterically controls RNA binding.
1. Nat Commun - published April 2, 2022
2. Cruz MA, Frederick TE, Mallimadugula UL, Singh S, Vithani N, Zimmerman MI, Porter JR, Moeder KE, Amarasinghe GK, Bowman GR
Secondary structure and ¹H, ¹⁵ N & ¹³C resonance assignments of the periplasmic domain of OutG, major pseudopilin from Dickeya dadantii type II secretion system.
1. Biomol NMR Assign - published April 2, 2022
2. Jacobsen T, Dazzoni R, Renault MG, Bardiaux B, Nilges M, Shevchik V, Izadi-Pruneyre N
Phosphoinositide phosphorylation sans kinase.
1. Nat Cell Biol - published April 2, 2022
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Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy.
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The role of nucleoside triphosphate hydrolase metallochaperones in making metalloenzymes.
1. Metallomics - published April 2, 2022
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A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer.
1. Sci Adv - published April 2, 2022
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Biomolecules capturing live bacteria from clinical samples.
1. Trends Biochem Sci - published April 2, 2022
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In crystallo observation of three metal ion promoted DNA polymerase misincorporation.
1. Nat Commun - published April 2, 2022
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BTB_BCL6 dimers as building blocks for reversible drug-induced protein oligomerization.
1. Cell Rep Methods - published April 2, 2022
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A kinesin-1 variant reveals motor-induced microtubule damage in cells.
1. Curr Biol - published April 2, 2022
2. Budaitis BG, Badieyan S, Yue Y, Blasius TL, Reinemann DN, Lang MJ, Cianfrocco MA, Verhey KJ
HIV-1 VIF and human APOBEC3G interaction directly observed through molecular specific labeling using a new dual promotor vector.
1. J Magn Reson - published April 2, 2022
2. Myint W, Schiffer CA, Matsuo H
The Nuclear Pore Complex: Birth, Life, and Death of a Cellular Behemoth.
1. Cells - published April 2, 2022
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LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants.
1. Cell Rep - published April 2, 2022
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A high-fidelity, virtual-reality, transurethral resection of bladder tumor simulator: Validation as a tool for training.
1. Can Urol Assoc J - published April 1, 2022
2. Moore J, Whalen S, Rowe N, Lee JY, Ordon M, Lantz Powers AG
Upstream open reading frames mediate autophagy-related protein translation.
1. Autophagy - published April 1, 2022
2. Yang Y, Gatica Mizala D, Liu X, Wu R, Kang R, Tang D, Klionsky DJ
Structural conservation among variants of the SARS-CoV-2 spike postfusion bundle.
1. Proc Natl Acad Sci U S A - published April 1, 2022
2. Yang K, Wang C, White KI, Pfuetzner RA, Esquivies L, Brunger AT
CSSR: assignment of secondary structure to coarse-grained RNA tertiary structures.
1. Acta Crystallogr D Struct Biol - published April 1, 2022
2. Zhang C, Pyle AM
Protein dynamics developments for the large scale and cryoEM: case study of ProDy 2.0.
1. Acta Crystallogr D Struct Biol - published April 1, 2022
2. Krieger JM, Sorzano COS, Carazo JM, Bahar I
On bias, variance, overfitting, gold standard and consensus in single-particle analysis by cryo-electron microscopy.
1. Acta Crystallogr D Struct Biol - published April 1, 2022
2. Sorzano COS, Jiménez-Moreno A, Maluenda D, Martínez M, Ramírez-Aportela E, Krieger J, Melero R, Cuervo A, Conesa J, Filipovic J, Conesa P, Del Caño L, Fonseca YC, Jiménez-de la Morena J, Losana P, Sánchez-García R, Strelak D, Fernández-Giménez E, de Isidro-Gómez FP, Herreros D, Vilas JL, Marabini R, Carazo JM
Expanding the phenotype of TTLL5-associated retinal dystrophy: a case series.
1. Orphanet J Rare Dis - published April 1, 2022
2. Oh JK, Vargas Del Valle JG, Lima de Carvalho JR Jr, Sun YJ, Levi SR, Ryu J, Yang J, Nagasaki T, Emanuelli A, Rasool N, Allikmets R, Sparrow JR, Izquierdo NJ, Duncan JL, Mahajan VB, Tsang SH
Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC.
1. Bioorg Med Chem Lett - published April 1, 2022
2. Gero TW, Heppner DE, Beyett TS, To C, Azevedo SC, Jang J, Bunnell T, Feru F, Li Z, Hee Shin B, Soroko KM, Gokhale PC, Gray NS, Jänne PA, Eck MJ, Scott DA
TCR-mimic bispecific antibodies to target the HIV-1 reservoir.
1. Proc Natl Acad Sci U S A - published April 1, 2022
2. Sengupta S, Board NL, Wu F, Moskovljevic M, Douglass J, Zhang J, Reinhold BR, Duke-Cohan J, Yu J, Reed MC, Tabdili Y, Azurmendi A, Fray EJ, Zhang H, Hsiue EH, Jenike K, Ho YC, Gabelli SB, Kinzler KW, Vogelstein B, Zhou S, Siliciano JD, Sadegh-Nasseri S, Reinherz EL, Siliciano RF
Molecular Structure of Single-Stranded DNA on the ZnS Surface of Quantum Dots.
1. ACS Nano - published April 1, 2022
2. Wei X, Chen C, Zhao Y, Harazinska E, Bathe M, Hernandez R
The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution.
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2. Nirmal AJ, Maliga Z, Vallius T, Quattrochi B, Chen AA, Jacobson CA, Pelletier RJ, Yapp C, Arias-Camison R, Chen YA, Lian CG, Murphy GF, Santagata S, Sorger PK
The partner-swapping sliding clamp loader exposed.
1. Nat Struct Mol Biol - published April 1, 2022
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A hypothalamic pathway for Augmentor α-controlled body weight regulation.
1. Proc Natl Acad Sci U S A - published April 1, 2022
2. Ahmed M, Kaur N, Cheng Q, Shanabrough M, Tretiakov EO, Harkany T, Horvath TL, Schlessinger J
Author Correction: Investigation of Cas9 antibodies in the human eye.
1. Nat Commun - published April 1, 2022
2. Toral MA, Charlesworth CT, Ng B, Chemudupati T, Homma S, Nakauchi H, Bassuk AG, Porteus MH, Mahajan VB
A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation.
1. Elife - published April 1, 2022
2. Boone M, Wang L, Lawrence R, Frost A, Walter P, Schoof M
The tethered peptide activation mechanism of adhesion GPCRs.
1. Nature - published April 1, 2022
2. Barros-Álvarez X, Nwokonko RM, Vizurraga A, Matzov D, He F, Papasergi-Scott MM, Robertson MJ, Panova O, Yardeni EH, Seven AB, Kwarcinski FE, Su H, Peroto MC, Meyerowitz JG, Shalev-Benami M, Tall GG, Skiniotis G
Isolation of a Potently Neutralizing and Protective Human Monoclonal Antibody Targeting Yellow Fever Virus.
1. mBio - published April 1, 2022
2. Doyle MP, Genualdi JR, Bailey AL, Kose N, Gainza C, Rodriguez J, Reeder KM, Nelson CA, Jethva PN, Sutton RE, Bombardi RG, Gross ML, Julander JG, Fremont DH, Diamond MS, Crowe JE Jr
Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1.
1. Cancer Discov - published April 1, 2022
2. Yuan X, Duan Y, Xiao Y, Sun K, Qi Y, Zhang Y, Ahmed Z, Moiani D, Yao J, Li H, Zhang L, Yuzhalin AE, Li P, Zhang C, Badu-Nkansah A, Saito Y, Liu X, Kuo WL, Ying H, Sun SC, Chang JC, Tainer JA, Yu D
A Comparative Analysis of the Membrane Binding and Remodeling Properties of Two Related Sorting Nexin Complexes Involved in Autophagy.
1. Biochemistry - published April 1, 2022
2. Reinhart EF, Katzenell S, Andhare D, Bauer KM, Ragusa MJ
Cryo-EM structure of the prothrombin-prothrombinase complex.
1. Blood - published April 1, 2022
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The bacterial yjdF riboswitch regulates translation through its tRNA-like fold.
1. J Biol Chem - published April 1, 2022
2. Trachman RJ 3rd, Passalacqua LFM, Ferré-D'Amaré AR
An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer.
1. Nat Cancer - published April 1, 2022
2. To C, Beyett TS, Jang J, Feng WW, Bahcall M, Haikala HM, Shin BH, Heppner DE, Rana JK, Leeper BA, Soroko KM, Poitras MJ, Gokhale PC, Kobayashi Y, Wahid K, Kurppa KJ, Gero TW, Cameron MD, Ogino A, Mushajiang M, Xu C, Zhang Y, Scott DA, Eck MJ, Gray NS, Jänne PA
CRISPR-Cas9 bends and twists DNA to read its sequence.
1. Nat Struct Mol Biol - published April 1, 2022
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Preserved recognition of Omicron Spike following COVID-19 mRNA vaccination in pregnancy.
1. Am J Obstet Gynecol - published April 1, 2022
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Sortase-Mediated Site-Specific Conjugation and ⁸⁹Zr-Radiolabeling of Designed Ankyrin Repeat Proteins for PET.
1. Mol Pharm - published April 1, 2022
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Mismatch discrimination and sequence bias during end-joining by DNA ligases.
1. Nucleic Acids Res - published April 1, 2022
2. Bilotti K, Potapov V, Pryor JM, Duckworth AT, Keck JL, Lohman GJS
An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses.
1. Sci Transl Med - published April 1, 2022
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A molecular beacon assay for monitoring RNA splicing.
1. Nucleic Acids Res - published April 1, 2022
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Dimerization-dependent membrane tethering by Atg23 is essential for yeast autophagy.
1. Cell Rep - published April 1, 2022
2. Hawkins WD, Leary KA, Andhare D, Popelka H, Klionsky DJ, Ragusa MJ
Structures of distant diphtheria toxin homologs reveal functional determinants of an evolutionarily conserved toxin scaffold.
1. Commun Biol - published April 1, 2022
2. Sugiman-Marangos SN, Gill SK, Mansfield MJ, Orrell KE, Doxey AC, Melnyk RA
Allosteric interactions prime androgen receptor dimerization and activation.
1. Mol Cell - published April 1, 2022
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Selective Macrocyclic Inhibitors of DYRK1A/B.
1. ACS Med Chem Lett - published April 1, 2022
2. Powell CE, Hatcher JM, Jiang J, Vatsan PS, Che J, Gray NS
Discovery of Phospholipase D Inhibitors with Improved Drug-like Properties and Central Nervous System Penetrance.
1. ACS Med Chem Lett - published April 1, 2022
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Structural and functional impact by SARS-CoV-2 Omicron spike mutations.
1. Cell Rep - published April 1, 2022
2. Zhang J, Cai Y, Lavine CL, Peng H, Zhu H, Anand K, Tong P, Gautam A, Mayer ML, Rits-Volloch S, Wang S, Sliz P, Wesemann DR, Yang W, Seaman MS, Lu J, Xiao T, Chen B
Structure of an influenza group 2-neutralizing antibody targeting the hemagglutinin stem supersite.
1. Structure - published April 1, 2022
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Protein engineering responses to the COVID-19 pandemic.
1. Curr Opin Struct Biol - published April 1, 2022
2. Hsieh CL, McLellan JS