Member Publications

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138 Member Publications for September 2021

A Method for Orthotopic Transplantation of Lung Cancer in Mice.
1. Methods Mol Biol - published September 25, 2021
2. Wilson AN, Chen B, Liu X, Kurie JM, Kim J
Biochemical Assays to Directly Assess Smoothened Activation by a Conformationally Sensitive Nanobody.
1. Methods Mol Biol - published September 25, 2021
2. Deshpande I, Manglik A
De Novo Powered Air-Purifying Respirator Design and Fabrication for Pandemic Response.
1. Front Bioeng Biotechnol - published September 23, 2021
2. Kothakonda A, Atta L, Plana D, Ward F, Davis C, Cramer A, Moran R, Freake J, Tian E, Mazor O, Gorelik P, Van C, Hansen C, Yang H, Li Y, Sinha MS, Li J, Yu SH, LeBoeuf NR, Sorger PK
DNA double-strand break repair in cancer: A path to achieving precision medicine.
1. Int Rev Cell Mol Biol - published September 11, 2021
2. Gillyard T, Davis J
Structural Comparisons of Cefotaximase (CTX-M-ase) Sub Family 1.
1. Front Microbiol - published September 10, 2021
2. Shurina BA, Page RC
Structural bioinformatic analysis of DsbA proteins and their pathogenicity associated substrates.
1. Comput Struct Biotechnol J - published September 10, 2021
2. Santos-Martin C, Wang G, Subedi P, Hor L, Totsika M, Paxman JJ, Heras B
Molecular investigation of artificial and natural sweeteners as potential anti-inflammatory agents.
1. J Biomol Struct Dyn - published September 9, 2021
2. Chontzopoulou E, Papaemmanouil CD, Chatziathanasiadou MV, Kolokouris D, Kiriakidi S, Konstantinidi A, Gerogianni I, Tselios T, Kostakis IK, Chrysina ED, Hadjipavlou-Litina D, Tzeli D, Tzakos AG, Mavromoustakos T
A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation.
1. Nat Metab - published September 9, 2021
2. Li L, Conradson DM, Bharat V, Kim MJ, Hsieh CH, Minhas PS, Papakyrikos AM, Durairaj AS, Ludlam A, Andreasson KI, Partridge L, Cianfrocco MA, Wang X
What's in the Black Box? - A Perspective on Software in Cryo-Electron Microscopy.
1. Biophys J - published September 9, 2021
2. Maji S, Frank J
Open Reading Frame 1 Protein of the Human Long Interspersed Nuclear Element 1 Retrotransposon Binds Multiple Equivalents of Lead.
1. J Am Chem Soc - published September 8, 2021
2. Pinter TBJ, Ruckthong L, Stuckey JA, Deb A, Penner-Hahn JE, Pecoraro VL
Imaging of retina cellular and subcellular structures using ptychographic hard X-ray tomography.
1. J Cell Sci - published September 8, 2021
2. Panneels V, Diaz A, Imsand C, Guizar-Sicairos M, Müller E, Bittermann AG, Ishikawa T, Menzel A, Kaech A, Holler M, Grimm C, Schertler G
Bioaccumulation of therapeutic drugs by human gut bacteria.
1. Nature - published September 8, 2021
2. Klünemann M, Andrejev S, Blasche S, Mateus A, Phapale P, Devendran S, Vappiani J, Simon B, Scott TA, Kafkia E, Konstantinidis D, Zirngibl K, Mastrorilli E, Banzhaf M, Mackmull MT, Hövelmann F, Nesme L, Brochado AR, Maier L, Bock T, Periwal V, Kumar M, Kim Y, Tramontano M, Schultz C, Beck M, Hennig J, Zimmermann M, Sévin DC, Cabreiro F, Savitski MM, Bork P, Typas A, Patil KR
Systematic engineering of optimized autonomous heavy-chain variable domains.
1. J Mol Biol - published September 8, 2021
2. Nilvebrant J, Ereño-Orbea J, Gorelik M, Julian MC, Tessier PM, Julien JP, Sidhu SS
Structure of mitotic chromosomes.
1. Mol Cell - published September 8, 2021
2. Beel AJ, Azubel M, Matteï PJ, Kornberg RD
Structure of SARS-CoV-2 spike protein.
1. Curr Opin Virol - published September 8, 2021
2. Zhang J, Xiao T, Cai Y, Chen B
Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies.
1. Cell Rep - published September 8, 2021
2. Jette CA, Cohen AA, Gnanapragasam PNP, Muecksch F, Lee YE, Huey-Tubman KE, Schmidt F, Hatziioannou T, Bieniasz PD, Nussenzweig MC, West AP Jr, Keeffe JR, Bjorkman PJ, Barnes CO
SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma.
1. Proc Natl Acad Sci U S A - published September 7, 2021
2. Andreano E, Piccini G, Licastro D, Casalino L, Johnson NV, Paciello I, Dal Monego S, Pantano E, Manganaro N, Manenti A, Manna R, Casa E, Hyseni I, Benincasa L, Montomoli E, Amaro RE, McLellan JS, Rappuoli R
Obligate movements of an active site-linked surface domain control RNA polymerase elongation and pausing via a Phe pocket anchor.
1. Proc Natl Acad Sci U S A - published September 7, 2021
2. Bao Y, Landick R
Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
1. Proc Natl Acad Sci U S A - published September 7, 2021
2. Gonzalez-Del Pino GL, Li K, Park E, Schmoker AM, Ha BH, Eck MJ
Cyclodextrins increase membrane tension and are universal activators of mechanosensitive channels.
1. Proc Natl Acad Sci U S A - published September 7, 2021
2. Cox CD, Zhang Y, Zhou Z, Walz T, Martinac B
Biochemical reconstitution defines new functions for membrane-bound glycosidases in assembly of the bacterial cell wall.
1. Proc Natl Acad Sci U S A - published September 7, 2021
2. Taguchi A, Page JE, Tsui HT, Winkler ME, Walker S
In Situ Covalent Functionalization of DNA Origami Virus-like Particles.
1. ACS Nano - published September 7, 2021
2. Knappe GA, Wamhoff EC, Read BJ, Irvine DJ, Bathe M
The enigmatic Placozoa part 2: Exploring evolutionary controversies and promising questions on earth and in space.
1. Bioessays - published September 7, 2021
2. Schierwater B, Osigus HJ, Bergmann T, Blackstone NW, Hadrys H, Hauslage J, Humbert PO, Kamm K, Kvansakul M, Wysocki K, DeSalle R
Targeting the Nuclear Receptor-Binding SET Domain Family of Histone Lysine Methyltransferases for Cancer Therapy: Recent Progress and Perspectives.
1. J Med Chem - published September 7, 2021
2. Shrestha A, Kim N, Lee SJ, Jeon YH, Song JJ, An H, Cho SJ, Kadayat TM, Chin J
The structural basis of Salmonella A₂B₅ toxin neutralization by antibodies targeting the glycan-receptor binding subunits.
1. Cell Rep - published September 7, 2021
2. Nguyen T, Richards AF, Neupane DP, Feathers JR, Yang YA, Sim JH, Byun H, Lee S, Ahn C, Van Slyke G, Fromme JC, Mantis NJ, Song J
Clostridioides difficile infection induces a rapid influx of bile acids into the gut during colonization of the host.
1. Cell Rep - published September 7, 2021
2. Wexler AG, Guiberson ER, Beavers WN, Shupe JA, Washington MK, Lacy DB, Caprioli RM, Spraggins JM, Skaar EP
Aurora A kinase activation: Different means to different ends.
1. J Cell Biol - published September 6, 2021
2. Tavernier N, Sicheri F, Pintard L
Computational study of non-conductive selectivity filter conformations and C-type inactivation in a voltage-dependent potassium channel.
1. J Gen Physiol - published September 6, 2021
2. Li J, Shen R, Rohaim A, Mendoza Uriarte R, Fajer M, Perozo E, Roux B
Structural basis for the recognition of deaminated nucleobases by an archaeal DNA polymerase.
1. Chembiochem - published September 6, 2021
2. Marx A, Kropp HM, Ludmann S, Diederichs K, Betz K
Publisher Correction: JunB is a key regulator of multiple myeloma bone marrow angiogenesis.
1. Leukemia - published September 6, 2021
2. Fan F, Malvestiti S, Vallet S, Lind J, Garcia-Manteiga JM, Morelli E, Jiang Q, Seckinger A, Hose D, Goldschmidt H, Stadlbauer A, Sun C, Mei H, Pecherstorfer M, Bakiri L, Wagner EF, Tonon G, Sattler M, Hu Y, Tassone P, Jaeger D, Podar K
Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens.
1. Nat Commun - published September 6, 2021
2. Hwang MS, Miller MS, Thirawatananond P, Douglass J, Wright KM, Hsiue EH, Mog BJ, Aytenfisu TY, Murphy MB, Aitana Azurmendi P, Skora AD, Pearlman AH, Paul S, DiNapoli SR, Konig MF, Bettegowda C, Pardoll DM, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S, Gabelli SB
Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism.
1. Nat Commun - published September 6, 2021
2. Maben Z, Arya R, Georgiadis D, Stratikos E, Stern LJ
New Advances in the Research of Resistance to Neoadjuvant Chemotherapy in Breast Cancer.
1. Int J Mol Sci - published September 6, 2021
2. An J, Peng C, Tang H, Liu X, Peng F
A Structural Update of Neutralizing Epitopes on the HIV Envelope, a Moving Target.
1. Viruses - published September 5, 2021
2. Parker Miller E, Finkelstein MT, Erdman MC, Seth PC, Fera D
The Macromolecular Complexes of Histones Affect Protein Arginine Methyltransferase Activities.
1. J Biol Chem - published September 4, 2021
2. Fulton MD, Cao M, Ho MC, Zhao X, Zheng YG
Evolving A RIG-I Antagonist: A Modified DNA Aptamer Mimics Viral RNA.
1. J Mol Biol - published September 3, 2021
2. Ren X, Gelinas AD, Linehan M, Iwasaki A, Wang W, Janjic N, Pyle AM
Cristae-dependent quality control of the mitochondrial genome.
1. Sci Adv - published September 3, 2021
2. Jakubke C, Roussou R, Maiser A, Schug C, Thoma F, Bunk D, Hörl D, Leonhardt H, Walter P, Klecker T, Osman C
Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques.
1. Proc Natl Acad Sci U S A - published September 2, 2021
2. King HAD, Joyce MG, Lakhal-Naouar I, Ahmed A, Cincotta CM, Subra C, Peachman KK, Hack HR, Chen RE, Thomas PV, Chen WH, Sankhala RS, Hajduczki A, Martinez EJ, Peterson CE, Chang WC, Choe M, Smith C, Headley JA, Elyard HA, Cook A, Anderson A, Wuertz KM, Dong M, Swafford I, Case JB, Currier JR, Lal KG, Amare MF, Dussupt V, Molnar S, Daye SP, Zeng X, Barkei EK, Alfson K, Staples HM, Carrion R, Krebs SJ, Paquin-Proulx D, Karasavvas N, Polonis VR, Jagodzinski LL, Vasan S, Scott PT, Huang Y, Nair MS, Ho DD, de Val N, Diamond MS, Lewis MG, Rao M, Matyas GR, Gromowski GD, Peel SA, Michael NL, Modjarrad K, Bolton DL
Implementing fluorescence enhancement, quenching, and FRET for investigating flap endonuclease 1 enzymatic reaction at the single-molecule level.
1. Comput Struct Biotechnol J - published September 2, 2021
2. Sobhy MA, Tehseen M, Takahashi M, Bralić A, De Biasio A, Hamdan SM
The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB.
1. Nat Commun - published September 2, 2021
2. Safarian S, Opel-Reading HK, Wu D, Mehdipour AR, Hards K, Harold LK, Radloff M, Stewart I, Welsch S, Hummer G, Cook GM, Krause KL, Michel H
Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells.
1. Mol Cell - published September 2, 2021
2. Donohoue PD, Pacesa M, Lau E, Vidal B, Irby MJ, Nyer DB, Rotstein T, Banh L, Toh MS, Gibson J, Kohrs B, Baek K, Owen ALG, Slorach EM, van Overbeek M, Fuller CK, May AP, Jinek M, Cameron P
Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile.
1. iScience - published September 2, 2021
2. Rujas E, Leaman DP, Insausti S, Carravilla P, García-Porras M, Largo E, Morillo I, Sánchez-Eugenia R, Zhang L, Cui H, Iloro I, Elortza F, Julien JP, Eggeling C, Zwick MB, Caaveiro JMM, Nieva JL
TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer.
1. Proc Natl Acad Sci U S A - published September 2, 2021
2. Agarwal N, Rinaldetti S, Cheikh BB, Zhou Q, Hass EP, Jones RT, Joshi M, LaBarbera DV, Knott SRV, Cech TR, Theodorescu D
Cryo-EM structure of the IL-10 receptor complex provides a blueprint for ligand engineering.
1. FEBS J - published September 2, 2021
2. Saxton RA, Garcia KC
Functional properties of oligomeric and monomeric forms of Helicobacter pylori VacA toxin.
1. Infect Immun - published September 2, 2021
2. Caso GC, McClain MS, Erwin AL, Truelock MD, Campbell AM, Leasure CS, Nagel M, Schey KL, Lacy DB, Ohi MD, Cover TL
Structural basis for antibody binding to adenylate cyclase toxin reveals RTX linkers as neutralization-sensitive epitopes.
1. PLoS Pathog - published September 2, 2021
2. Goldsmith JA, DiVenere AM, Maynard JA, McLellan JS
INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors.
1. Cancer Discov - published September 2, 2021
2. Li Q, Jiang B, Guo J, Shao H, Del Priore IS, Chang Q, Kudo R, Li Z, Razavi P, Liu B, Boghossian AS, Rees MG, Ronan MM, Roth JA, Donovan KA, Palafox M, Reis-Filho JS, de Stanchina E, Fischer ES, Rosen N, Serra V, Koff A, Chodera JD, Gray NS, Chandarlapaty S
Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions.
1. mBio - published September 2, 2021
2. O'Toole GA, Crabbé A, Kümmerli R, LiPuma JJ, Bomberger JM, Davies JC, Limoli D, Phelan VV, Bliska JB, DePas WH, Dietrich LE, Hampton TH, Hunter R, Khursigara CM, Price-Whelan A, Ashare A, Cramer RA, Goldberg JB, Harrison F, Hogan DA, Henson MA, Madden DR, Mayers JR, Nadell C, Newman D, Prince A, Rivett DW, Schwartzman JD, Schultz D, Sheppard DC, Smyth AR, Spero MA, Stanton BA, Turner PE, van der Gast C, Whelan FJ, Whitaker R, Whiteson K
Robust three-dimensional nanotube-in-micropillar array electrodes to facilitate size independent electroporation in blood cell therapy.
1. Lab Chip - published September 2, 2021
2. Liu X, Chang AY, Ma Y, Hua L, Yang Z, Wang S
Unsupervised methods for detection of neural states: case study of hippocampal-amygdala interactions.
1. eNeuro - published September 2, 2021
2. Cocina F, Vitalis A, Caflisch A
Structures of artificially designed discrete RNA nanoarchitectures at near-atomic resolution.
1. Sci Adv - published September 2, 2021
2. Liu D, Shao Y, Piccirilli JA, Weizmann Y
Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail.
1. Nat Microbiol - published September 2, 2021
2. Dong J, Zost SJ, Greaney AJ, Starr TN, Dingens AS, Chen EC, Chen RE, Case JB, Sutton RE, Gilchuk P, Rodriguez J, Armstrong E, Gainza C, Nargi RS, Binshtein E, Xie X, Zhang X, Shi PY, Logue J, Weston S, McGrath ME, Frieman MB, Brady T, Tuffy KM, Bright H, Loo YM, McTamney PM, Esser MT, Carnahan RH, Diamond MS, Bloom JD, Crowe JE Jr
ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine.
1. Blood Cancer J - published September 2, 2021
2. Rahmani NE, Ramachandra N, Sahu S, Gitego N, Lopez A, Pradhan K, Bhagat TD, Gordon-Mitchell S, Pena BR, Kazemi M, Rao K, Giricz O, Maqbool SB, Olea R, Zhao Y, Zhang J, Dolatshad H, Tittrea V, Tatwavedi D, Singh S, Lee J, Sun T, Steidl U, Shastri A, Inoue D, Abdel-Wahab O, Pellagatti A, Gavathiotis E, Boultwood J, Verma A
Epistasis shapes the fitness landscape of an allosteric specificity switch.
1. Nat Commun - published September 2, 2021
2. Nishikawa KK, Hoppe N, Smith R, Bingman C, Raman S
Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential.
1. Nat Commun - published September 2, 2021
2. Meyer B, Chiaravalli J, Gellenoncourt S, Brownridge P, Bryne DP, Daly LA, Grauslys A, Walter M, Agou F, Chakrabarti LA, Craik CS, Eyers CE, Eyers PA, Gambin Y, Jones AR, Sierecki E, Verdin E, Vignuzzi M, Emmott E
The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe.
1. Proc Natl Acad Sci U S A - published September 2, 2021
2. Borowska MT, Drees C, Yarawsky AE, Viswanathan M, Ryan SM, Bunker JJ, Herr AB, Bendelac A, Adams EJ
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma.
1. Nat Commun - published September 2, 2021
2. Liang HC, Costanza M, Prutsch N, Zimmerman MW, Gurnhofer E, Montes-Mojarro IA, Abraham BJ, Prokoph N, Stoiber S, Tangermann S, Lobello C, Oppelt J, Anagnostopoulos I, Hielscher T, Pervez S, Klapper W, Zammarchi F, Silva DA, Garcia KC, Baker D, Janz M, Schleussner N, Fend F, Pospíšilová Š, Janiková A, Wallwitz J, Stoiber D, Simonitsch-Klupp I, Cerroni L, Pileri S, de Leval L, Sibon D, Fataccioli V, Gaulard P, Assaf C, Knörr F, Damm-Welk C, Woessmann W, Turner SD, Look AT, Mathas S, Kenner L, Merkel O
Treatment of glioblastoma with current oHSV variants reveals differences in efficacy and immune cell recruitment.
1. Mol Ther Oncolytics - published September 2, 2021
2. Jackson JW, Hall BL, Marzulli M, Shah VK, Bailey L, Chiocca EA, Goins WF, Kohanbash G, Cohen JB, Glorioso JC
Interprotomer disulfide-stabilized variants of the human metapneumovirus fusion glycoprotein induce high titer-neutralizing responses.
1. Proc Natl Acad Sci U S A - published September 2, 2021
2. Stewart-Jones GBE, Gorman J, Ou L, Zhang B, Joyce MG, Yang L, Cheng C, Chuang GY, Foulds KE, Kong WP, Olia AS, Sastry M, Shen CH, Todd JP, Tsybovsky Y, Verardi R, Yang Y, Collins PL, Corti D, Lanzavecchia A, Scorpio DG, Mascola JR, Buchholz UJ, Kwong PD
Distinct allosteric mechanisms of first-generation MsbA inhibitors.
1. Science - published September 2, 2021
2. Thélot FA, Zhang W, Song K, Xu C, Huang J, Liao M
Lrp1 is a host entry factor for Rift Valley fever virus.
1. Cell - published September 2, 2021
2. Ganaie SS, Schwarz MM, McMillen CM, Price DA, Feng AX, Albe JR, Wang W, Miersch S, Orvedahl A, Cole AR, Sentmanat MF, Mishra N, Boyles DA, Koenig ZT, Kujawa MR, Demers MA, Hoehl RM, Moyle AB, Wagner ND, Stubbs SH, Cardarelli L, Teyra J, McElroy A, Gross ML, Whelan SPJ, Doench J, Cui X, Brett TJ, Sidhu SS, Virgin HW, Egawa T, Leung DW, Amarasinghe GK, Hartman AL
The mechanisms of integral membrane protein biogenesis.
1. Nat Rev Mol Cell Biol - published September 2, 2021
2. Hegde RS, Keenan RJ
Carbocation Footprinting of Soluble and Transmembrane Proteins.
1. Anal Chem - published September 2, 2021
2. Sun J, Li S, Li W, Gross ML
Target highlights in CASP14: analysis of models by structure providers.
1. Proteins - published September 2, 2021
2. Alexander LT, Lepore R, Kryshtafovych A, Adamopoulos A, Alahuhta M, Arvin AM, Bomble YJ, Böttcher B, Breyton C, Chiarini V, Chinnam NB, Chiu W, Fidelis K, Grinter R, Gupta GD, Hartmann MD, Hayes CS, Heidebrecht T, Ilari A, Joachimiak A, Kim Y, Linares R, Lovering AL, Lunin VV, Lupas AN, Makbul C, Michalska K, Moult J, Mukherjee PK, Nutt WS, Oliver SL, Perrakis A, Stols L, Tainer JA, Topf M, Tsutakawa SE, Valdivia-Delgado M, Schwede T
A Solid Supported Membrane Electrophysiology Assay for Efficient Characterization of Ion-Coupled Transport.
1. J Biol Chem - published September 2, 2021
2. Thomas NE, Feng W, Henzler-Wildman KA
Structure of the peripheral arm of a minimalistic respiratory complex I.
1. Structure - published September 2, 2021
2. Schimpf J, Oppermann S, Gerasimova T, Santos Seica AF, Hellwig P, Grishkovskaya I, Wohlwend D, Haselbach D, Friedrich T
Structural basis and regulation of the reductive stress response.
1. Cell - published September 2, 2021
2. Manford AG, Mena EL, Shih KY, Gee CL, McMinimy R, Martínez-González B, Sherriff R, Lew B, Zoltek M, Rodríguez-Pérez F, Woldesenbet M, Kuriyan J, Rape M
β-arrestin-biased allosteric modulator potentiates Carvedilol stimulated β adrenergic receptor cardioprotection.
1. Mol Pharmacol - published September 2, 2021
2. Wang J, Pani B, Gokhan I, Xiong X, Kahsai AW, Jiang H, Ahn S, Lefkowitz RJ, Rockman HA
Metabolism of HSAN1- and T2DM-associated 1-deoxy-sphingolipids inhibits the migration of fibroblasts.
1. J Lipid Res - published September 2, 2021
2. Karsai G, Steiner R, Kaech A, Lone MA, von Eckardstein A, Hornemann T
A palmitoylation code controls PI4KIIIα complex formation and PI(4,5)P2 homeostasis at the plasma membrane.
1. J Cell Sci - published September 2, 2021
2. Batrouni AG, Bag N, Phan H, Baird BA, Baskin JM
Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants.
1. Nat Commun - published September 2, 2021
2. Li T, Xue W, Zheng Q, Song S, Yang C, Xiong H, Zhang S, Hong M, Zhang Y, Yu H, Zhang Y, Sun H, Huang Y, Deng T, Chi X, Li J, Wang S, Zhou L, Chen T, Wang Y, Cheng T, Zhang T, Yuan Q, Zhao Q, Zhang J, McLellan JS, Zhou ZH, Zhang Z, Li S, Gu Y, Xia N
Unique positive cooperativity between the β-arrestin-biased β-blocker Carvedilol and a small molecule positive allosteric modulator of the β2-Adrenergic Receptor.
1. Mol Pharmacol - published September 2, 2021
2. Pani B, Ahn S, Rambarat PK, Vege S, Kahsai AW, Liu A, Valan BN, Staus DP, Costa T, Lefkowitz RJ
Rapid tool for cell nanoarchitecture integrity assessment.
1. J Struct Biol - published September 2, 2021
2. Gaietta G, Swift MF, Volkmann N, Hanein D
Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases in the Prevention of Experimental Invasive Aspergillosis.
1. mBio - published September 2, 2021
2. Ostapska H, Raju D, Lehoux M, Lacdao I, Gilbert S, Sivarajah P, Bamford NC, Baker P, Nguyen TTM, Zacharias CA, Gravelat FN, Howell PL, Sheppard DC
Spectroscopic investigation of iron(III) cysteamine dioxygenase in the presence of substrate (analogs): implications for the nature of substrate-bound reaction intermediates.
1. J Biol Inorg Chem - published September 2, 2021
2. Fernandez RL, Juntunen ND, Fox BG, Brunold TC
α-Aminoboronates: recent advances in their preparation and synthetic applications.
1. Chem Soc Rev - published September 2, 2021
2. Ming W, Soor HS, Liu X, Trofimova A, Yudin AK, Marder TB
Medicinal Au(I) compounds targeting urease as prospective antimicrobial agents: unveiling the structural basis for enzyme inhibition.
1. Dalton Trans - published September 2, 2021
2. Mazzei L, Massai L, Cianci M, Messori L, Ciurli S
DNA asymmetry promotes SUMO modification of the single-stranded DNA-binding protein RPA.
1. EMBO J - published September 2, 2021
2. Cappadocia L, Kochańczyk T, Lima CD
Interactions of ubiquitin and CHMP5 with the V domain of HD-PTP reveals role for regulation of Vps4 ATPase.
1. Mol Biol Cell - published September 2, 2021
2. Pashkova N, Yu L, Schnicker NJ, Tseng CC, Gakhar L, Katzmann DJ, Piper RC
Paired heavy- and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses.
1. Cell Rep - published September 2, 2021
2. Banach BB, Cerutti G, Fahad AS, Shen CH, Oliveira De Souza M, Katsamba PS, Tsybovsky Y, Wang P, Nair MS, Huang Y, Francino-Urdániz IM, Steiner PJ, Gutiérrez-González M, Liu L, López Acevedo SN, Nazzari AF, Wolfe JR, Luo Y, Olia AS, Teng IT, Yu J, Zhou T, Reddem ER, Bimela J, Pan X, Madan B, Laflin AD, Nimrania R, Yuen KY, Whitehead TA, Ho DD, Kwong PD, Shapiro L, DeKosky BJ
Probing multiple enzymatic methylation events in real time with NMR spectroscopy.
1. Biophys J - published September 2, 2021
2. Usher ET, Namitz KEW, Cosgrove MS, Showalter SA
Insights into homology search from cryo-EM structures of RecA-DNA recombination intermediates.
1. Curr Opin Genet Dev - published September 2, 2021
2. Yang H, Pavletich NP
Crabtree/Warburg-like aerobic xylose fermentation by engineered Saccharomyces cerevisiae.
1. Metab Eng - published September 2, 2021
2. Lee SB, Tremaine M, Place M, Liu L, Pier A, Krause DJ, Xie D, Zhang Y, Landick R, Gasch AP, Hittinger CT, Sato TK
Implications of a highly divergent dengue virus strain for cross-neutralization, protection, and vaccine immunity.
1. Cell Host Microbe - published September 2, 2021
2. Chen RE, Smith BK, Errico JM, Gordon DN, Winkler ES, VanBlargan LA, Desai C, Handley SA, Dowd KA, Amaro-Carambot E, Cardosa MJ, Sariol CA, Kallas EG, Sékaly RP, Vasilakis N, Fremont DH, Whitehead SS, Pierson TC, Diamond MS
Characteristics and operation outcomes of neuro-oncology patients after COVID-19 pandemic - A case series.
1. Interdiscip Neurosurg - published September 1, 2021
2. Zou Y, Zhang J, Zhang T, Feng Y, Xiong Z, Xu C, Gong P, Si J, Chen J
Higher-order assemblies in immune signaling: supramolecular complexes and phase separation.
1. Protein Cell - published September 1, 2021
2. Xia S, Chen Z, Shen C, Fu TM
Insights into modular polyketide synthase loops aided by repetitive sequences.
1. Proteins - published September 1, 2021
2. Hirsch M, Kumru K, Desai RR, Fitzgerald BJ, Miyazawa T, Ray KA, Saif N, Spears S, Keatinge-Clay AT
Characterization of modeled inhibitory binding sites on isoform one of the Na⁺/H⁺ exchanger.
1. Biochim Biophys Acta Biomembr - published September 1, 2021
2. Li X, Kim J, Yang J, Dutta D, Fliegel L
Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA and monitors genome integrity.
1. Life Sci Alliance - published September 1, 2021
2. Mohanty BK, Karam JA, Howley BV, Dalton AC, Grelet S, Dincman T, Streitfeld WS, Yoon JH, Balakrishnan L, Chazin WJ, Long DT, Howe PH
A protocol for qualitative and quantitative measurement of endosomal processing using hot spot analysis.
1. STAR Protoc - published September 1, 2021
2. Clement CC, Nanaware PP, Stern LJ, Santambrogio L
Protocol for the use of focused ion-beam milling to prepare crystalline lamellae for microcrystal electron diffraction (MicroED).
1. STAR Protoc - published September 1, 2021
2. Martynowycz MW, Gonen T
In situ imaging of bacterial outer membrane projections and associated protein complexes using electron cryo-tomography.
1. Elife - published September 1, 2021
2. Kaplan M, Chreifi G, Metskas LA, Liedtke J, Wood CR, Oikonomou CM, Nicolas WJ, Subramanian P, Zacharoff LA, Wang Y, Chang YW, Beeby M, Dobro M, Zhu Y, McBride M, Briegel A, Shaffer C, Jensen GJ
The enigmatic Placozoa part 1: Exploring evolutionary controversies and poor ecological knowledge.
1. Bioessays - published September 1, 2021
2. Schierwater B, Osigus HJ, Bergmann T, Blackstone NW, Hadrys H, Hauslage J, Humbert PO, Kamm K, Kvansakul M, Wysocki K, DeSalle R
A design approach for layer-by-layer surface-mediated siRNA delivery.
1. Acta Biomater - published September 1, 2021
2. Chou JJ, Berger AG, Jalili-Firoozinezhad S, Hammond PT
A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects.
1. J Med Chem - published September 1, 2021
2. Chakraborty S, DiBerto JF, Faouzi A, Bernhard SM, Gutridge AM, Ramsey S, Zhou Y, Provasi D, Nuthikattu N, Jilakara R, Nelson MNF, Asher WB, Eans SO, Wilson LL, Chintala SM, Filizola M, van Rijn RM, Margolis EB, Roth BL, McLaughlin JP, Che T, Sames D, Javitch JA, Majumdar S
Structural analysis of receptors and actin polarity in platelet protrusions.
1. Proc Natl Acad Sci U S A - published September 1, 2021
2. Sorrentino S, Conesa JJ, Cuervo A, Melero R, Martins B, Fernandez-Gimenez E, de Isidro-Gomez FP, de la Morena J, Studt JD, Sorzano COS, Eibauer M, Carazo JM, Medalia O
Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode.
1. Biochemistry - published September 1, 2021
2. Lockbaum GJ, Henes M, Lee JM, Timm J, Nalivaika EA, Thompson PR, Kurt Yilmaz N, Schiffer CA
Diphthamide promotes TOR signaling by increasing the translation of proteins in the TORC1 pathway.
1. Proc Natl Acad Sci U S A - published September 1, 2021
2. Zhang Y, Lin Z, Zhu J, Wang M, Lin H
Rapid prototyping of arbitrary 2D and 3D wireframe DNA origami.
1. Nucleic Acids Res - published September 1, 2021
2. Jun H, Wang X, Parsons MF, Bricker WP, John T, Li S, Jackson S, Chiu W, Bathe M
Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing.
1. Nucleic Acids Res - published September 1, 2021
2. Jahns H, Degaonkar R, Podbevsek P, Gupta S, Bisbe A, Aluri K, Szeto J, Kumar P, LeBlanc S, Racie T, Brown CR, Castoreno A, Guenther DC, Jadhav V, Maier MA, Plavec J, Egli M, Manoharan M, Zlatev I
Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade.
1. Proc Natl Acad Sci U S A - published September 1, 2021
2. Qu C, Park JY, Yun MW, He QT, Yang F, Kim K, Ham D, Li RR, Iverson TM, Gurevich VV, Sun JP, Chung KY
Rational design of ASCT2 inhibitors using an integrated experimental-computational approach.
1. Proc Natl Acad Sci U S A - published September 1, 2021
2. Garibsingh RA, Ndaru E, Garaeva AA, Shi Y, Zielewicz L, Zakrepine P, Bonomi M, Slotboom DJ, Paulino C, Grewer C, Schlessinger A
Simultaneous exposure to intracellular and extracellular photosensitizers for the treatment of Staphylococcus aureus infections.
1. Antimicrob Agents Chemother - published September 1, 2021
2. Drury SL, Miller AR, Laut CL, Walter AB, Bennett MR, Su M, Bai M, Jing B, Joseph SB, Metzger EJ, Bane CE, Black CC, Macdonald MT, Dutter BF, Romaine IM, Waterson AG, Sulikowski GA, Jansen ED, Crowe JE Jr, Sciotti RJ, Skaar EP
Nucleolar maturation of the human small subunit processome.
1. Science - published September 1, 2021
2. Singh S, Vanden Broeck A, Miller L, Chaker-Margot M, Klinge S
The molecular mechanism of RIG-I activation and signaling.
1. Immunol Rev - published September 1, 2021
2. Thoresen D, Wang W, Galls D, Guo R, Xu L, Pyle AM
Compendium of Causative Genes and Their Encoded Proteins for Common Monogenic Disorders.
1. Protein Sci - published September 1, 2021
2. Apgar TL, Sanders CR
Magnetic Control and Real-Time Monitoring of Stem Cell Differentiation by the Ligand Nanoassembly.
1. Small - published September 1, 2021
2. Lee S, Kim MS, Patel KD, Choi H, Thangam R, Yoon J, Koo TM, Jung HJ, Min S, Bae G, Kim Y, Han SB, Kang N, Kim M, Li N, Fu HE, Jeon YS, Song JJ, Kim DH, Park S, Choi JW, Paulmurugan R, Kang YC, Lee H, Wei Q, Dravid VP, Lee KB, Kim YK, Kang H
Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens.
1. Sci Adv - published September 1, 2021
2. Monteith AJ, Miller JM, Maxwell CN, Chazin WJ, Skaar EP
A complete Protocadherin-19 ectodomain model for evaluating epilepsy-causing mutations and potential protein interaction sites.
1. Structure - published September 1, 2021
2. Hudson JD, Tamilselvan E, Sotomayor M, Cooper SR
Inosine Substitutions in RNA Activate Latent G-Quadruplexes.
1. J Am Chem Soc - published September 1, 2021
2. Hagen T, Laski A, Brümmer A, Pruška A, Schlösser V, Cléry A, Allain FH, Zenobi R, Bergmann S, Hall J
Trypanosoma brucei Tim50 Possesses PAP Activity and Plays a Critical Role in Cell Cycle Regulation and Parasite Infectivity.
1. mBio - published September 1, 2021
2. Tripathi A, Singha UK, Cooley A, Gillyard T, Krystofiak E, Pratap S, Davis J, Chaudhuri M
Lattice micropatterning for cryo-electron tomography studies of cell-cell contacts.
1. J Struct Biol - published September 1, 2021
2. Engel L, Vasquez CG, Montabana EA, Sow BM, Walkiewicz MP, Weis WI, Dunn AR
Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS.
1. Elife - published September 1, 2021
2. Sheedlo MJ, Durie CL, Chung JM, Chang L, Roberts J, Swanson M, Lacy DB, Ohi MD
Distinctive Roles of Two Acinetobactin Isomers in Challenging Host Nutritional Immunity.
1. mBio - published September 1, 2021
2. Kim M, Kim DY, Song WY, Park SE, Harrison SA, Chazin WJ, Oh MH, Kim HJ
Computational and biochemical analysis of type IV pilus dynamics and stability.
1. Structure - published September 1, 2021
2. Karami Y, López-Castilla A, Ori A, Thomassin JL, Bardiaux B, Malliavin T, Izadi-Pruneyre N, Francetic O, Nilges M
N-Terminal Modification of Gly-His-tagged Proteins with Azidogluconolactone.
1. Chembiochem - published September 1, 2021
2. Brune KD, Liekniņa I, Sutov G, Morris AR, Jovicevic D, Kalniņš G, Kazāks A, Kluga R, Kastaljana S, Zajakina A, Jansons J, Skrastiņa D, Spunde K, Cohen AA, Bjorkman PJ, Morris HR, Suna E, Tārs K
SUV39 SET domains mediate crosstalk of heterochromatic histone marks.
1. Elife - published September 1, 2021
2. Stirpe A, Guidotti N, Northall SJ, Kilic S, Hainard A, Vadas O, Fierz B, Schalch T
Global Proximity Interactome of the Human Macroautophagy Pathway.
1. Autophagy - published September 1, 2021
2. Tu YXI, Sydor AM, Coyaud E, Laurent EMN, Dyer D, Mellouk N, St-Germain J, Vernon RM, Forman-Kay JD, Li T, Hua R, Zhao K, Ridgway ND, Kim PK, Raught B, Brumell JH
Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains.
1. Nat Commun - published September 1, 2021
2. Deneka D, Rutz S, Hutter CAJ, Seeger MA, Sawicka M, Dutzler R
Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites.
1. Cell Chem Biol - published September 1, 2021
2. Lee JH, Mosher EP, Lee YS, Bumpus NN, Berger JM
An engineered IL-2 partial agonist promotes CD8⁺ T cell stemness.
1. Nature - published September 1, 2021
2. Mo F, Yu Z, Li P, Oh J, Spolski R, Zhao L, Glassman CR, Yamamoto TN, Chen Y, Golebiowski FM, Hermans D, Majri-Morrison S, Picton LK, Liao W, Ren M, Zhuang X, Mitra S, Lin JX, Gattinoni L, Powell JD, Restifo NP, Garcia KC, Leonard WJ
HOW TIM PROTEINS DIFFERENTIALLY EXPLOIT MEMBRANE FEATURES TO ATTAIN ROBUST TARGET SENSITIVITY.
1. Biophys J - published September 1, 2021
2. Kerr D, Gong Z, Suwatthee T, Luoma A, Roy S, Scarpaci R, Hwang HL, Henderson JM, Cao KD, Bu W, Lin B, Tietjen GT, Steck TL, Adams EJ, Lee KYC
Measuring in vivo protein turnover and exchange in yeast macromolecular assemblies.
1. STAR Protoc - published September 1, 2021
2. Hakhverdyan Z, Molloy KR, Subbotin RI, Fernandez-Martinez J, Chait BT, Rout MP
Identifying digenic disease genes via machine learning in the Undiagnosed Diseases Network.
1. Am J Hum Genet - published September 1, 2021
2. Mukherjee S, Cogan JD, Newman JH, Phillips JA 3rd, Hamid R, Undiagnosed Diseases Network., Meiler J, Capra JA
Advances in TRP channel drug discovery: from target validation to clinical studies.
1. Nat Rev Drug Discov - published September 1, 2021
2. Koivisto AP, Belvisi MG, Gaudet R, Szallasi A
Structural characterization of NrnC identifies unifying features of dinucleotidases.
1. Elife - published September 1, 2021
2. Lormand JD, Kim SK, Walters-Marrah GA, Brownfield BA, Fromme JC, Winkler WC, Goodson JR, Lee VT, Sondermann H
Synthesis of Oligoribonucleotides Containing a 2'-Amino-5'-S-phosphorothiolate Linkage.
1. J Org Chem - published September 1, 2021
2. Li NS, Koo SC, Piccirilli JA
The biological and clinical significance of emerging SARS-CoV-2 variants.
1. Nat Rev Genet - published September 1, 2021
2. Tao K, Tzou PL, Nouhin J, Gupta RK, de Oliveira T, Kosakovsky Pond SL, Fera D, Shafer RW
Oncogenic truncations of ASXL1 enhance a motif for BRD4 ET-domain binding.
1. J Mol Biol - published September 1, 2021
2. Burgess AE, Kleffmann T, Mace PD
Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species.
1. Cell Metab - published September 1, 2021
2. Zhang XJ, Liu X, Hu M, Zhao GJ, Sun D, Cheng X, Xiang H, Huang YP, Tian RF, Shen LJ, Ma JP, Wang HP, Tian S, Gan S, Xu H, Liao R, Zou T, Ji YX, Zhang P, Cai J, Wang ZV, Meng G, Xu Q, Wang Y, Ma XL, Liu PP, Huang Z, Zhu L, She ZG, Zhang X, Bai L, Yang H, Lu Z, Li H
PD-L1^P146R is prognostic and a negative predictor of response to immunotherapy in gastric cancer.
1. Mol Ther - published September 1, 2021
2. Li Q, Zhou ZW, Lu J, Luo H, Wang SN, Peng Y, Deng MS, Song GB, Wang JM, Wei X, Wang D, Westover KD, Xu CX
Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID).
1. BMJ Open Respir Res - published September 1, 2021
2. Wild JM, Porter JC, Molyneaux PL, George PM, Stewart I, Allen RJ, Aul R, Baillie JK, Barratt SL, Beirne P, Bianchi SM, Blaikley JF, Brooke J, Chaudhuri N, Collier G, Denneny EK, Docherty A, Fabbri L, Gibbons MA, Gleeson FV, Gooptu B, Hall IP, Hanley NA, Heightman M, Hillman TE, Johnson SR, Jones MG, Khan F, Lawson R, Mehta P, Mitchell JA, Platé M, Poinasamy K, Quint JK, Rivera-Ortega P, Semple M, Simpson AJ, Smith D, Spears M, Spencer LG, Stanel SC, Thickett DR, Thompson AAR, Walsh SL, Weatherley ND, Weeks ME, Wootton DG, Brightling CE, Chambers RC, Ho LP, Jacob J, Piper Hanley K, Wain LV, Jenkins RG
Micropatterning Transmission Electron Microscopy Grids to Direct Cell Positioning within Whole-Cell Cryo-Electron Tomography Workflows.
1. J Vis Exp - published September 1, 2021
2. Sibert BS, Kim JY, Yang JE, Wright ER
Binding of l-kynurenine to X. campestris tryptophan 2,3-dioxygenase.
1. J Inorg Biochem - published September 1, 2021
2. Basran J, Booth ES, Campbell LP, Thackray SJ, Jesani MH, Clayden J, Moody PCE, Mowat CG, Kwon H, Raven EL
Recent and Future Advances in the Chemoenzymatic Synthesis of Homogeneous Glycans for Bacterial Glycoconjugate Vaccine Development.
1. Vaccines (Basel) - published September 1, 2021
2. Adegbite A, McCarthy PC
A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly.
1. Viruses - published September 1, 2021
2. Obr M, Schur FKM, Dick RA
Potent neutralization of SARS-CoV-2 variants of concern by an antibody with an uncommon genetic signature and structural mode of spike recognition.
1. Cell Rep - published September 1, 2021
2. Kramer KJ, Johnson NV, Shiakolas AR, Suryadevara N, Periasamy S, Raju N, Williams JK, Wrapp D, Zost SJ, Walker LM, Wall SC, Holt CM, Hsieh CL, Sutton RE, Paulo A, Nargi RS, Davidson E, Doranz BJ, Crowe JE Jr, Bukreyev A, Carnahan RH, McLellan JS, Georgiev IS
Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines.
1. Cell - published September 1, 2021
2. Walls AC, Miranda MC, Schäfer A, Pham MN, Greaney A, Arunachalam PS, Navarro MJ, Tortorici MA, Rogers K, O'Connor MA, Shirreff L, Ferrell DE, Bowen J, Brunette N, Kepl E, Zepeda SK, Starr T, Hsieh CL, Fiala B, Wrenn S, Pettie D, Sydeman C, Sprouse KR, Johnson M, Blackstone A, Ravichandran R, Ogohara C, Carter L, Tilles SW, Rappuoli R, Leist SR, Martinez DR, Clark M, Tisch R, O'Hagan DT, Van Der Most R, Van Voorhis WC, Corti D, McLellan JS, Kleanthous H, Sheahan TP, Smith KD, Fuller DH, Villinger F, Bloom J, Pulendran B, Baric RS, King NP, Veesler D