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178 Member Publications for March 2021

The Molecular Function of PURA and Its Implications in Neurological Diseases.
1. Front Genet - published March 29, 2021
2. Molitor L, Bacher S, Burczyk S, Niessing D
Minerva: a light-weight, narrative image browser for multiplexed tissue images.
1. J Open Source Softw - published March 26, 2021
2. Hoffer J, Rashid R, Muhlich JL, Chen YA, Russell DPW, Ruokonen J, Krueger R, Pfister H, Santagata S, Sorger PK
Structure of the EphB6 receptor ectodomain.
1. PLoS One - published March 26, 2021
2. Mason EO, Goldgur Y, Robev D, Freywald A, Nikolov DB, Himanen JP
Redox-sensitive carrier-free nanoparticles self-assembled by disulfide-linked paclitaxel-tetramethylpyrazine conjugate for combination cancer chemotherapy.
1. Theranostics - published March 23, 2021
2. Zou L, Liu X, Li J, Li W, Zhang L, Fu C, Zhang J, Gu Z
Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds.
1. RSC Adv - published March 18, 2021
2. Carrasquel-Ursulaez W, Reeves RD, Dehghany M, Jones C, Schomaker JM, Chanda B
Polarization Effects in Water-Mediated Selective Cation Transport across a Narrow Transmembrane Channel.
1. J Chem Theory Comput - published March 9, 2021
2. Ngo V, Li H, MacKerell AD Jr, Allen TW, Roux B, Noskov S
Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.
1. Proc Natl Acad Sci U S A - published March 9, 2021
2. Ahmed MS, Wang P, Nguyen NUN, Nakada Y, Menendez-Montes I, Ismail M, Bachoo R, Henkemeyer M, Sadek HA, Kandil ES
Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3.
1. Proc Natl Acad Sci U S A - published March 9, 2021
2. Qiu M, Glass Z, Chen J, Haas M, Jin X, Zhao X, Rui X, Ye Z, Li Y, Zhang F, Xu Q
Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2.
1. Proc Natl Acad Sci U S A - published March 9, 2021
2. Pei J, Wagner ND, Zou AJ, Chatterjee S, Borek D, Cole AR, Kim PJ, Basler CF, Otwinowski Z, Gross ML, Amarasinghe GK, Leung DW
Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody.
1. Proc Natl Acad Sci U S A - published March 9, 2021
2. Madan B, Zhang B, Xu K, Chao CW, O'Dell S, Wolfe JR, Chuang GY, Fahad AS, Geng H, Kong R, Louder MK, Nguyen TD, Rawi R, Schön A, Sheng Z, Nimrania R, Wang Y, Zhou T, Lin BC, Doria-Rose NA, Shapiro L, Kwong PD, DeKosky BJ
Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation.
1. Proc Natl Acad Sci U S A - published March 9, 2021
2. Patil K, Jordan EJ, Park JH, Suresh K, Smith CM, Lemmon AA, Mossé YP, Lemmon MA, Radhakrishnan R
Mapping the functional landscape of the receptor binding domain of T7 bacteriophage by deep mutational scanning.
1. Elife - published March 9, 2021
2. Huss P, Meger A, Leander M, Nishikawa KK, Raman S
Itaconate confers tolerance to late NLRP3 inflammasome activation.
1. Cell Rep - published March 9, 2021
2. Bambouskova M, Potuckova L, Paulenda T, Kerndl M, Mogilenko DA, Lizotte K, Swain A, Hayes S, Sheldon RD, Kim H, Kapadnis U, Ellis AE, Isaguirre C, Burdess S, Laha A, Amarasinghe GK, Chubukov V, Roddy TP, Diamond MS, Jones RG, Simons DM, Artyomov MN
Full methylation of H3K27 by PRC2 is dispensable for initial embryoid body formation but required to maintain differentiated cell identity.
1. Development - published March 9, 2021
2. Miller SA, Damle M, Kim J, Kingston RE
Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery.
1. Immunity - published March 9, 2021
2. Chiou SH, Tseng D, Reuben A, Mallajosyula V, Molina IS, Conley S, Wilhelmy J, McSween AM, Yang X, Nishimiya D, Sinha R, Nabet BY, Wang C, Shrager JB, Berry MF, Backhus L, Lui NS, Wakelee HA, Neal JW, Padda SK, Berry GJ, Delaidelli A, Sorensen PH, Sotillo E, Tran P, Benson JA, Richards R, Labanieh L, Klysz DD, Louis DM, Feldman SA, Diehn M, Weissman IL, Zhang J, Wistuba II, Futreal PA, Heymach JV, Garcia KC, Mackall CL, Davis MM
Maternal Iron Deficiency Modulates Placental Transcriptome and Proteome in Mid-Gestation of Mouse Pregnancy.
1. J Nutr - published March 9, 2021
2. Cao C, Prado MA, Sun L, Rockowitz S, Sliz P, Paulo JA, Finley D, Fleming MD
Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery.
1. Immunity - published March 9, 2021
2. Clement CC, Nanaware PP, Yamazaki T, Negroni MP, Ramesh K, Morozova K, Thangaswamy S, Graves A, Kim HJ, Li TW, Vigano' M, Soni RK, Gadina M, Tse HY, Galluzzi L, Roche PA, Denzin LK, Stern LJ, Santambrogio L
Single-Shot Vaccines against Bovine Respiratory Syncytial Virus (BRSV): Comparative Evaluation of Long-Term Protection after Immunization in the Presence of BRSV-Specific Maternal Antibodies.
1. Vaccines (Basel) - published March 9, 2021
2. Valarcher JF, Hägglund S, Näslund K, Jouneau L, Malmström E, Boulesteix O, Pinard A, Leguéré D, Deslis A, Gauthier D, Dubuquoy C, Pietralunga V, Rémot A, Falk A, Shevchenko G, Bergström Lind S, Von Brömssen C, Vargmar K, Zhang B, Kwong PD, Rodriguez MJ, Garcia Duran M, Schwartz-Cornil I, Taylor G, Riffault S
HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase.
1. Elife - published March 8, 2021
2. Rudolph J, Roberts G, Muthurajan UM, Luger K
Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7.
1. Nature - published March 8, 2021
2. Wang P, Nair MS, Liu L, Iketani S, Luo Y, Guo Y, Wang M, Yu J, Zhang B, Kwong PD, Graham BS, Mascola JR, Chang JY, Yin MT, Sobieszczyk M, Kyratsous CA, Shapiro L, Sheng Z, Huang Y, Ho DD
Cryo-EM structures of human coagulation factors V and Va.
1. Blood - published March 8, 2021
2. Ruben EA, Rau MJ, Fitzpatrick J, Di Cera E
Structural basis of the human Scribble-Vangl2 association in health and disease.
1. Biochem J - published March 8, 2021
2. How JY, Stephens R, Lim KYB, Humbert PO, Kvansakul M
Structure of the FA core ubiquitin ligase closing the ID clamp on DNA.
1. Nat Struct Mol Biol - published March 8, 2021
2. Wang S, Wang R, Peralta C, Yaseen A, Pavletich NP
NMR and EPR reveal a compaction of the RNA-binding protein FUS upon droplet formation.
1. Nat Chem Biol - published March 8, 2021
2. Emmanouilidis L, Esteban-Hofer L, Damberger FF, de Vries T, Nguyen CKX, Ibáñez LF, Mergenthal S, Klotzsch E, Yulikov M, Jeschke G, Allain FH
Conformational dynamics in interleukin 17A and 17F functional complexes is a key determinant of receptor A affinity and specificity.
1. Cytokine - published March 8, 2021
2. Waters LC, Veverka V, Strong SL, Muskett FW, Dedi N, Lawson ADG, Prosser CE, Taylor RJ, Henry AJ, Carr MD
Oligomeric complexes formed by Redβ single strand annealing protein in its different DNA bound states.
1. Nucleic Acids Res - published March 8, 2021
2. Caldwell BJ, Norris A, Zakharova E, Smith CE, Wheat CT, Choudhary D, Sotomayor M, Wysocki VH, Bell CE
Efficient and flexible synthesis of new photoactivatable propofol analogs.
1. Bioorg Med Chem Lett - published March 8, 2021
2. Skinner KA, Wzorek JS, Kahne D, Gaudet R
Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies.
1. bioRxiv - published March 8, 2021
2. Muecksch F, Weisblum Y, Barnes CO, Schmidt F, Schaefer-Babajew D, Lorenzi JCC, Flyak AI, DeLaitsch AT, Huey-Tubman KE, Hou S, Schiffer CA, Gaebler C, Wang Z, Da Silva J, Poston D, Finkin S, Cho A, Cipolla M, Oliveira TY, Millard KG, Ramos V, Gazumyan A, Rutkowska M, Caskey M, Nussenzweig MC, Bjorkman PJ, Hatziioannou T, Bieniasz PD
Engineering of Challenging G Protein-Coupled Receptors for Structure Determination and Biophysical Studies.
1. Molecules - published March 8, 2021
2. Waltenspühl Y, Ehrenmann J, Klenk C, Plückthun A
Pirtobrutinib in relapsed or refractory B-cell malignancies (BRUIN): a phase 1/2 study.
1. Lancet - published March 6, 2021
2. Mato AR, Shah NN, Jurczak W, Cheah CY, Pagel JM, Woyach JA, Fakhri B, Eyre TA, Lamanna N, Patel MR, Alencar A, Lech-Maranda E, Wierda WG, Coombs CC, Gerson JN, Ghia P, Le Gouill S, Lewis DJ, Sundaram S, Cohen JB, Flinn IW, Tam CS, Barve MA, Kuss B, Taylor J, Abdel-Wahab O, Schuster SJ, Palomba ML, Lewis KL, Roeker LE, Davids MS, Tan XN, Fenske TS, Wallin J, Tsai DE, Ku NC, Zhu E, Chen J, Yin M, Nair B, Ebata K, Marella N, Brown JR, Wang M
In vitro and in vivo inhibition of malaria parasite infection by monoclonal antibodies against Plasmodium falciparum circumsporozoite protein (CSP).
1. Sci Rep - published March 5, 2021
2. Livingstone MC, Bitzer AA, Giri A, Luo K, Sankhala RS, Choe M, Zou X, Dennison SM, Li Y, Washington W, Ngauy V, Tomaras GD, Joyce MG, Batchelor AH, Dutta S
A "Drug Sweeping" State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa.
1. Structure - published March 4, 2021
2. Fabre L, Ntreh AT, Yazidi A, Leus IV, Weeks JW, Bhattacharyya S, Ruickoldt J, Rouiller I, Zgurskaya HI, Sygusch J
Defective lysosomal storage in Fabry Disease modifies mitochondrial structure, metabolism and turnover in renal epithelial cells.
1. J Inherit Metab Dis - published March 4, 2021
2. Schumann A, Schaller K, Belche V, Cybulla M, Grünert SC, Moers N, Sass JO, Kaech A, Hannibal L, Spiekerkoetter U
Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.
1. PLoS One - published March 4, 2021
2. Cohen AA, Yang Z, Gnanapragasam PNP, Ou S, Dam KA, Wang H, Bjorkman PJ
Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity.
1. Genome Biol - published March 4, 2021
2. Sorek M, Oweis W, Nissim-Rafinia M, Maman M, Simon S, Hession CC, Adiconis X, Simmons SK, Sanjana NE, Shi X, Lu C, Pan JQ, Xu X, Pouladi MA, Ellerby LM, Zhang F, Levin JZ, Meshorer E
Integrated genomic analysis reveals regulatory pathways and dynamic landscapes of the tRNA transcriptome.
1. Sci Rep - published March 4, 2021
2. Sun Z, Tan J, Zhao M, Peng Q, Zhou M, Zuo S, Wu F, Li X, Dong Y, Xie M, Yang Y, Zhou J, Liu X, He Q, He Z, Yu X, He Q
Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies.
1. Nat Med - published March 4, 2021
2. Chen RE, Zhang X, Case JB, Winkler ES, Liu Y, VanBlargan LA, Liu J, Errico JM, Xie X, Suryadevara N, Gilchuk P, Zost SJ, Tahan S, Droit L, Turner JS, Kim W, Schmitz AJ, Thapa M, Wang D, Boon ACM, Presti RM, O'Halloran JA, Kim AHJ, Deepak P, Pinto D, Fremont DH, Crowe JE Jr, Corti D, Virgin HW, Ellebedy AH, Shi PY, Diamond MS
N-terminal transmembrane-helix epitope tag for x-ray crystallography and electron microscopy of small membrane proteins.
1. J Mol Biol - published March 4, 2021
2. McIlwain BC, Erwin AL, Davis AR, Ben Koff B, Chang L, Bylund T, Chuang GY, Kwong PD, Ohi MD, Lai YT, Stockbridge RB
An unexpected P-cluster like intermediate en route to the nitrogenase FeMo-co.
1. Chem Sci - published March 4, 2021
2. Jenner LP, Cherrier MV, Amara P, Rubio LM, Nicolet Y
Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates.
1. Sci Transl Med - published March 3, 2021
2. Darricarrère N, Qiu Y, Kanekiyo M, Creanga A, Gillespie RA, Moin SM, Saleh J, Sancho J, Chou TH, Zhou Y, Zhang R, Dai S, Moody A, Saunders KO, Crank MC, Mascola JR, Graham BS, Wei CJ, Nabel GJ
Dual role of endothelial Myct1 in tumor angiogenesis and tumor immunity.
1. Sci Transl Med - published March 3, 2021
2. Kabir AU, Subramanian M, Lee DH, Wang X, Krchma K, Wu J, Naismith T, Halabi CM, Kim JY, Pulous FE, Petrich BG, Kim S, Park HC, Hanson PI, Pan H, Wickline SA, Fremont DH, Park C, Choi K
Structural insights into the inhibition of glycine reuptake.
1. Nature - published March 3, 2021
2. Shahsavar A, Stohler P, Bourenkov G, Zimmermann I, Siegrist M, Guba W, Pinard E, Sinning S, Seeger MA, Schneider TR, Dawson RJP, Nissen P
Allogeneic transplantation after PD-1 blockade for classic Hodgkin lymphoma.
1. Leukemia - published March 3, 2021
2. Merryman RW, Castagna L, Giordano L, Ho VT, Corradini P, Guidetti A, Casadei B, Bond DA, Jaglowski S, Spinner MA, Arai S, Lowsky R, Shah GL, Perales MA, De Colella JMS, Blaise D, Herrera AF, Shouse G, Spilleboudt C, Ansell SM, Nieto Y, Badar T, Hamadani M, Feldman TA, Dahncke L, Singh AK, McGuirk JP, Nishihori T, Chavez J, Serritella AV, Kline J, Mohty M, Dulery R, Stamatoulas A, Houot R, Manson G, Moles-Moreau MP, Orvain C, Bouabdallah K, Modi D, Ramchandren R, Lekakis L, Beitinjaneh A, Frigault MJ, Chen YB, Lynch RC, Smith SD, Rao U, Byrne M, Romancik JT, Cohen JB, Nathan S, Phillips T, Joyce RM, Rahimian M, Bashey A, Ballard HJ, Svoboda J, Torri V, Sollini M, De Philippis C, Magagnoli M, Santoro A, Armand P, Zinzani PL, Carlo-Stella C
DeepAlign, a 3D Alignment Method based on Regionalized Deep Learning for Cryo-EM.
1. J Struct Biol - published March 3, 2021
2. Jiménez-Moreno A, Střelák D, Filipovič J, Carazo JM, Sorzano COS
An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation.
1. Prog Biophys Mol Biol - published March 3, 2021
2. Nguyen MT, Moiani D, Ahmed Z, Arvai AS, Namjoshi S, Shin DS, Fedorov Y, Selvik EJ, Jones DE, Pink J, Yan Y, Laverty DJ, Nagel ZD, Tainer JA, Gerson SL
Intestinal host response to SARS-CoV-2 infection and COVID-19 outcomes in patients with gastrointestinal symptoms.
1. Gastroenterology - published March 3, 2021
2. Livanos AE, Jha D, Cossarini F, Gonzalez-Reiche AS, Tokuyama M, Aydillo T, Parigi TL, Ladinsky MS, Ramos I, Dunleavy K, Lee B, Dixon R, Chen ST, Martinez-Delgado G, Nagula S, Bruce EA, Ko HM, Glicksberg BS, Nadkarni G, Pujadas E, Reidy J, Naymagon S, Grinspan A, Ahmad J, Tankelevich M, Bram Y, Gordon R, Sharma K, Houldsworth J, Britton GJ, Chen-Liaw A, Spindler MP, Plitt T, Wang P, Cerutti A, Faith JJ, Colombel JF, Kenigsberg E, Argmann C, Merad M, Gnjatic S, Harpaz N, Danese S, Cordon-Cardo C, Rahman A, Schwartz RE, Kumta NA, Aghemo A, Bjorkman PJ, Petralia F, van Bakel H, Garcia-Sastre A, Mehandru S
Structural Mechanisms for Replicating DNA in Eukaryotes.
1. Annu Rev Biochem - published March 3, 2021
2. Attali I, Botchan MR, Berger JM
Intrapleural Fibrinolytics and Deoxyribonuclease for Treatment of Indwelling Pleural Catheter-Related Pleural Infection: A Multi-Center Observational Study.
1. Respiration - published March 3, 2021
2. Fitzgerald DB, Muruganandan S, Tsim S, Ip H, Asciak R, Walker S, Uribe Becerra JP, Majid A, Ahmed L, Rahman NM, Maskell NA, Blyth KG, Lee YCG
Crystal structure of an inulosucrase from Halalkalicoccus jeotgali B3T-a halophilic archaeal strain.
1. FEBS J - published March 3, 2021
2. Ghauri K, Pijning T, Munawar N, Ali H, Ghauri MA, Anwar MA, Wallis R
Crystal structures of influenza nucleoprotein complexed with nucleic acid provide insights into the mechanism of RNA interaction.
1. Nucleic Acids Res - published March 3, 2021
2. Tang YS, Xu S, Chen YW, Wang JH, Shaw PC
Thymosin β4 protects against aortic aneurysm via endocytic regulation of growth factor signaling.
1. J Clin Invest - published March 3, 2021
2. Munshaw S, Bruche S, Redpath AN, Jones A, Patel J, Dubé KN, Lee R, Hester SS, Davies R, Neal G, Handa A, Sattler M, Fischer R, Channon KM, Smart N
Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2.
1. Elife - published March 3, 2021
2. Xie Y, Clarke BP, Kim YJ, Ivey AL, Hill PS, Shi Y, Ren Y
Arf1 orchestrates Rab GTPase conversion at the trans-Golgi network.
1. Mol Biol Cell - published March 3, 2021
2. Thomas LL, Highland CM, Fromme JC
A positively charged surface patch on the pestivirus NS3 protease module plays an important role in modulating NS3 helicase activity and virus production.
1. Arch Virol - published March 3, 2021
2. Zheng F, Yi W, Liu W, Zhu H, Gong P, Pan Z
Peripheral Methionine Residues Impact Flavin Photoreduction and Protonation in an Engineered LOV Domain Light Sensor.
1. Biochemistry - published March 3, 2021
2. Yee EF, Oldemeyer S, Böhm E, Ganguly A, York DM, Kottke T, Crane BR
Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons.
1. Cell Rep - published March 3, 2021
2. Ipsaro JJ, O'Brien PA, Bhattacharya S, Palmer AG 3rd, Joshua-Tor L
Arf1 directly recruits the Pik1-Frq1 PI4K complex to regulate the final stages of Golgi maturation.
1. Mol Biol Cell - published March 3, 2021
2. Highland CM, Fromme JC
Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice.
1. Sci Transl Med - published March 3, 2021
2. Ito N, Riyadh MA, Ahmad SAI, Hattori S, Kanemura Y, Kiyonari H, Abe T, Furuta Y, Shinmyo Y, Kaneko N, Hirota Y, Lupo G, Hatakeyama J, Abdulhaleem M FA, Anam MB, Yamaguchi M, Takeo T, Takebayashi H, Takebayashi M, Oike Y, Nakagata N, Shimamura K, Holtzman MJ, Takahashi Y, Guillemot F, Miyakawa T, Sawamoto K, Ohta K
Structural basis of malaria RIFIN binding by LILRB1-containing antibodies.
1. Nature - published March 3, 2021
2. Chen Y, Xu K, Piccoli L, Foglierini M, Tan J, Jin W, Gorman J, Tsybovsky Y, Zhang B, Traore B, Silacci-Fregni C, Daubenberger C, Crompton PD, Geiger R, Sallusto F, Kwong PD, Lanzavecchia A
Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism.
1. J Biol Chem - published March 3, 2021
2. Tao J, Berthet A, Citron YR, Tsiolaki PL, Stanley R, Gestwicki JE, Agard DA, McConlogue L
Effectiveness of mechanical cardiopulmonary resuscitation for patients with COVID-19 and in hospital cardiac arrest.
1. Resuscitation - published March 3, 2021
2. Bhardwaj A, Alwakeel M, Wang X, Duggal A, Gaieski DF, Fadel FA
The renaissance in biophysics and molecular biology enabled by the interface of DNA repair and replication with cancer.
1. Prog Biophys Mol Biol - published March 3, 2021
2. Zhang X, Blundell T, Tainer JA
Inhibitor Development against p7 Channel in Hepatitis C Virus.
1. Molecules - published March 3, 2021
2. Wei S, Hu X, Du L, Zhao L, Xue H, Liu C, Chou JJ, Zhong J, Tong Y, Wang S, OuYang B
Structural basis for the initiation of COPII vesicle biogenesis.
1. Structure - published March 3, 2021
2. Joiner AMN, Fromme JC
Ongoing Global and Regional Adaptive Evolution of SARS-CoV-2.
1. bioRxiv - published March 2, 2021
2. Rochman ND, Wolf YI, Faure G, Mutz P, Zhang F, Koonin EV
What Every Reader Should Know About Studies Using Electronic Health Record Data but May Be Afraid to Ask.
1. J Med Internet Res - published March 2, 2021
2. Kohane IS, Aronow BJ, Avillach P, Beaulieu-Jones BK, Bellazzi R, Bradford RL, Brat GA, Cannataro M, Cimino JJ, García-Barrio N, Gehlenborg N, Ghassemi M, Gutiérrez-Sacristán A, Hanauer DA, Holmes JH, Hong C, Klann JG, Loh NHW, Luo Y, Mandl KD, Daniar M, Moore JH, Murphy SN, Neuraz A, Ngiam KY, Omenn GS, Palmer N, Patel LP, Pedrera-Jiménez M, Sliz P, South AM, Tan ALM, Taylor DM, Taylor BW, Torti C, Vallejos AK, Wagholikar KB, Consortium For Clinical Characterization Of COVID-19 By EHR (4CE)., Weber GM, Cai T
AID overexpression leads to aggressive murine CLL and non-Ig mutations that mirror human neoplasms.
1. Blood - published March 2, 2021
2. Morande PE, Yan XJ, Sepulveda-Yanez JH, Seija N, Marquez ME, Sotelo NS, Abreu C, Crispo M, Fernández-Graña G, Rego N, Bois T, Methot SP, Palacios F, Remedi V, Rai KR, Buschiazzo A, Di Noia JM, Navarrete MA, Chiorazzi N, Oppezzo P
Contributions of the Four Essential Entry Glycoproteins to HSV-1 Tropism and the Selection of Entry Routes.
1. mBio - published March 2, 2021
2. Hilterbrand AT, Daly RE, Heldwein EE
Author Correction: Design of biologically active binary protein 2D materials.
1. Nature - published March 2, 2021
2. Ben-Sasson AJ, Watson JL, Sheffler W, Johnson MC, Bittleston A, Somasundaram L, Decarreau J, Jiao F, Chen J, Mela I, Drabek AA, Jarrett SM, Blacklow SC, Kaminski CF, Hura GL, De Yoreo JJ, Kollman JM, Ruohola-Baker H, Derivery E, Baker D
Structure-function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting.
1. Nat Commun - published March 2, 2021
2. Du Z, Brown BP, Kim S, Ferguson D, Pavlick DC, Jayakumaran G, Benayed R, Gallant JN, Zhang YK, Yan Y, Red-Brewer M, Ali SM, Schrock AB, Zehir A, Ladanyi M, Smith AW, Meiler J, Lovly CM
Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2.
1. Proc Natl Acad Sci U S A - published March 2, 2021
2. Liu Y, Hu G, Wang Y, Ren W, Zhao X, Ji F, Zhu Y, Feng F, Gong M, Ju X, Zhu Y, Cai X, Lan J, Guo J, Xie M, Dong L, Zhu Z, Na J, Wu J, Lan X, Xie Y, Wang X, Yuan Z, Zhang R, Ding Q
Novel RT-ddPCR assays for simultaneous quantification of multiple noncoding and coding regions of SARS-CoV-2 RNA.
1. J Virol Methods - published March 2, 2021
2. Telwatte S, Kumar N, Vallejo-Gracia A, Kumar GR, Lu CM, Ott M, Wong JK, Yukl SA
Direct Structural Insights into GABA_A Receptor Pharmacology.
1. Trends Biochem Sci - published March 2, 2021
2. Kim JJ, Hibbs RE
An in vitro reconstituted U1 snRNP allows the study of the disordered regions of the particle and the interactions with proteins and ligands.
1. Nucleic Acids Res - published March 2, 2021
2. Campagne S, de Vries T, Malard F, Afanasyev P, Dorn G, Dedic E, Kohlbrecher J, Boehringer D, Cléry A, Allain FH
Elusive Intermediate State Key in the Conversion of ATP Hydrolysis into Useful Work Driving the Ca²⁺ Pump SERCA.
1. J Phys Chem B - published March 2, 2021
2. Thirman J, Rui H, Roux B
Molecular assemblies of the catalytic domain of SOS with KRas and oncogenic mutants.
1. Proc Natl Acad Sci U S A - published March 2, 2021
2. Moghadamchargari Z, Shirzadeh M, Liu C, Schrecke S, Packianathan C, Russell DH, Zhao M, Laganowsky A
Protein design-scapes generated by microfluidic DNA assembly elucidate domain coupling in the bacterial histidine kinase CpxA.
1. Proc Natl Acad Sci U S A - published March 2, 2021
2. Clark IC, Mensa B, Ochs CJ, Schmidt NW, Mravic M, Quintana FJ, DeGrado WF, Abate AR
Targeting loss of heterozygosity for cancer-specific immunotherapy.
1. Proc Natl Acad Sci U S A - published March 2, 2021
2. Hwang MS, Mog BJ, Douglass J, Pearlman AH, Hsiue EH, Paul S, DiNapoli SR, Konig MF, Pardoll DM, Gabelli SB, Bettegowda C, Papadopoulos N, Vogelstein B, Zhou S, Kinzler KW
Oligomeric quaternary structure of Escherichia coli and Mycobacterium smegmatis Lhr helicases is nucleated by a novel C-terminal domain composed of five winged-helix modules.
1. Nucleic Acids Res - published March 2, 2021
2. Warren GM, Wang J, Patel DJ, Shuman S
Using culturomics and social media data to characterize wildlife consumption.
1. Conserv Biol - published March 2, 2021
2. Li J, Hu Q
Two-Dimensional Barriers for Probing Conformational Shifts in Macrocycles.
1. J Am Chem Soc - published March 2, 2021
2. Kobori S, Huh S, Appavoo SD, Yudin AK
Symptoms of Depression in Patients with Chemosensory Disorders.
1. ORL J Otorhinolaryngol Relat Spec - published March 2, 2021
2. Chen B, Benzien C, Faria V, Ning Y, Cuevas M, Linke J, Croy I, Haehner A, Hummel T
Time resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling.
1. Elife - published March 2, 2021
2. Vemulapalli V, Chylek LA, Erickson A, Pfeiffer A, Gabriel KH, LaRochelle J, Subramanian K, Cao R, Stegmaier K, Mohseni M, LaMarche MJ, Acker MG, Sorger PK, Gygi SP, Blacklow SC
Discovery and resistance mechanism of a selective CDK12 degrader.
1. Nat Chem Biol - published March 2, 2021
2. Jiang B, Gao Y, Che J, Lu W, Kaltheuner IH, Dries R, Kalocsay M, Berberich MJ, Jiang J, You I, Kwiatkowski N, Riching KM, Daniels DL, Sorger PK, Geyer M, Zhang T, Gray NS
Backbone chemical shift spectral assignments of SARS coronavirus-2 non-structural protein nsp9.
1. Biomol NMR Assign - published March 2, 2021
2. F Dudás E, Puglisi R, Korn SM, Alfano C, Bellone ML, Piaz FD, Kelly G, Monaca E, Schlundt A, Schwalbe H, Pastore A
An Approach for the Real-Time Quantification of Cytosolic Protein-Protein Interactions in Living Cells.
1. ACS Sens - published March 2, 2021
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1. Chem Rev - published March 2, 2021
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Structure analysis suggests Ess1 isomerizes the carboxy-terminal domain of RNA polymerase II via a bivalent anchoring mechanism.
1. Commun Biol - published March 2, 2021
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Local deuteration enables NMR observation of methyl groups in proteins from eukaryotic and cell-free expression systems.
1. Angew Chem Int Ed Engl - published March 2, 2021
2. Dubey A, Stoyanov N, Viennet T, Chhabra S, Elter S, Borggräfe J, Viegas A, Nowak RP, Burdziev N, Petrov O, Fischer ES, Etzkorn M, Gelev V, Arthanari H
The actomyosin interface contains an evolutionary conserved core and an ancillary interface involved in specificity.
1. Nat Commun - published March 2, 2021
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Influenza Virus RNA-Dependent RNA Polymerase and the Host Transcriptional Apparatus.
1. Annu Rev Biochem - published March 2, 2021
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¹H, ¹³C, and ¹⁵N backbone chemical-shift assignments of SARS-CoV-2 non-structural protein 1 (leader protein).
1. Biomol NMR Assign - published March 2, 2021
2. Wang Y, Kirkpatrick J, Zur Lage S, Korn SM, Neißner K, Schwalbe H, Schlundt A, Carlomagno T
Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice.
1. Nature - published March 2, 2021
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Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry.
1. Nat Commun - published March 2, 2021
2. Tavernier N, Thomas Y, Vigneron S, Maisonneuve P, Orlicky S, Mader P, Regmi SG, Van Hove L, Levinson NM, Gasmi-Seabrook G, Joly N, Poteau M, Velez-Aguilera G, Gavet O, Castro A, Dasso M, Lorca T, Sicheri F, Pintard L
A tumor-specific mechanism of T_reg enrichment mediated by the integrin αvβ8.
1. Sci Immunol - published March 2, 2021
2. Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL
The role of biofactors in the prevention and treatment of age-related diseases.
1. Biofactors - published March 2, 2021
2. Frank J, Kisters K, Stirban OA, Obeid R, Lorkowski S, Wallert M, Egert S, Podszun MC, Eckert GP, Pettersen JA, Venturelli S, Classen HG, Golombek J
Distinct intramolecular interactions regulate autoinhibition of vinculin binding in αT-catenin and αE-catenin.
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1. Nat Methods - published March 2, 2021
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Telegenetics for inherited retinal diseases in the COVID-19 environment.
1. Int J Retina Vitreous - published March 2, 2021
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Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation.
1. Nat Commun - published March 2, 2021
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Ceramide-1-phosphate transfer protein (CPTP) regulation by phosphoinositides^.
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Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations.
1. ACS Cent Sci - published March 2, 2021
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Configurational Entropy of Folded Proteins and Its Importance for Intrinsically Disordered Proteins.
1. Int J Mol Sci - published March 2, 2021
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De novo Powered Air-Purifying Respirator Design and Fabrication for Pandemic Response.
1. medRxiv - published March 2, 2021
2. Kothakonda A, Atta L, Plana D, Ward F, Davis C, Cramer A, Moran R, Freake J, Tian E, Mazor O, Gorelik P, Van C, Hansen C, Yang H, Sinha MS, Li J, Yu SH, LeBoeuf NR, Sorger PK
Predicting aqueous solubility by QSPR modeling.
1. J Mol Graph Model - published March 2, 2021
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Expression and purification of active human kinases using Pichia pastoris as a general-purpose host.
1. Protein Expr Purif - published March 1, 2021
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Solving the α-helix correspondence problem at medium-resolution Cryo-EM maps through modeling and 3D matching.
1. J Mol Graph Model - published March 1, 2021
2. Behkamal B, Naghibzadeh M, Pagnani A, Saberi MR, Al Nasr K
Potent Trivalent Inhibitors of Thrombin through Hybridization of Salivary Sulfopeptides from Hematophagous Arthropods.
1. Angew Chem Int Ed Engl - published March 1, 2021
2. Agten SM, Watson EE, Ripoll-Rozada J, Dowman LJ, Wu MCL, Alwis I, Jackson SP, Pereira PJB, Payne RJ
Archaea: The Final Frontier of Chromatin.
1. J Mol Biol - published March 1, 2021
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Carbapenem Use Is Driving the Evolution of Imipenemase 1 Variants.
1. Antimicrob Agents Chemother - published March 1, 2021
2. Cheng Z, Bethel CR, Thomas PW, Shurina BA, Alao JP, Thomas CA, Yang K, Marshall SH, Zhang H, Sturgill AM, Kravats AN, Page RC, Fast W, Bonomo RA, Crowder MW
Dynein regulates Kv7.4 channel trafficking from the cell membrane.
1. J Gen Physiol - published March 1, 2021
2. van der Horst J, Rognant S, Abbott GW, Ozhathil LC, Hägglund P, Barrese V, Chuang CY, Jespersen T, Davies MJ, Greenwood IA, Gourdon P, Aalkjær C, Jepps TA
Isolation and characterization of extracellular vesicles produced by cell lines.
1. STAR Protoc - published March 1, 2021
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Mechanisms of nonvesicular lipid transport.
1. J Cell Biol - published March 1, 2021
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Mechanisms of spacer acquisition by sequential assembly of the adaptation module in Synechocystis.
1. Nucleic Acids Res - published March 1, 2021
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Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.
1. medRxiv - published March 1, 2021
2. Garcia-Beltran WF, Lam EC, St Denis K, Nitido AD, Garcia ZH, Hauser BM, Feldman J, Pavlovic MN, Gregory DJ, Poznansky MC, Sigal A, Schmidt AG, Iafrate AJ, Naranbhai V, Balazs AB
The Matrix Revisited: Opening Night for the Pel Polysaccharide Across Eubacterial Kingdoms.
1. Microbiol Insights - published March 1, 2021
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Bispecific antibodies targeting mutant RAS neoantigens.
1. Sci Immunol - published March 1, 2021
2. Douglass J, Hsiue EH, Mog BJ, Hwang MS, DiNapoli SR, Pearlman AH, Miller MS, Wright KM, Azurmendi PA, Wang Q, Paul S, Schaefer A, Skora AD, Molin MD, Konig MF, Liu Q, Watson E, Li Y, Murphy MB, Pardoll DM, Bettegowda C, Papadopoulos N, Gabelli SB, Kinzler KW, Vogelstein B, Zhou S
TCR beta chain-directed bispecific antibodies for the treatment of T-cell cancers.
1. Sci Transl Med - published March 1, 2021
2. Paul S, Pearlman AH, Douglass J, Mog BJ, Hsiue EH, Hwang MS, DiNapoli SR, Konig MF, Brown PA, Wright KM, Sur S, Gabelli SB, Li Y, Ghiaur G, Pardoll D, Papadopoulos N, Bettegowda C, Kinzler KW, Zhou S, Vogelstein B
Targeting multiple enzymes in vitamin K metabolism for anticoagulation.
1. J Thromb Haemost - published March 1, 2021
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Targeting a neoantigen derived from a common TP53 mutation.
1. Science - published March 1, 2021
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Antibodies with potent and broad neutralizing activity against antigenically diverse and highly transmissible SARS-CoV-2 variants.
1. bioRxiv - published March 1, 2021
2. Wang L, Zhou T, Zhang Y, Yang ES, Schramm CA, Shi W, Pegu A, Oloninyi OK, Ransier A, Darko S, Narpala SR, Hatcher C, Martinez DR, Tsybovsky Y, Phung E, Abiona OM, Cale EM, Chang LA, Corbett KS, DiPiazza AT, Gordon IJ, Leung K, Liu T, Mason RD, Nazzari A, Novik L, Olia AS, Doria-Rose NA, Stephens T, Stringham CD, Talana CA, Teng IT, Wagner D, Widge AT, Zhang B, Roederer M, Ledgerwood JE, Ruckwardt TJ, Gaudinski MR, Baric RS, Graham BS, McDermott AB, Douek DC, Kwong PD, Mascola JR, Sullivan NJ, Misasi J
Efficient purification and assembly of ribonucleoprotein complex for interaction analysis by MST assay coupled with GaMD simulations.
1. STAR Protoc - published March 1, 2021
2. Gao Y, Cao D, Pawnikar S, Akhter S, Miao Y, Liang B
Natural products that target the cell envelope.
1. Curr Opin Microbiol - published March 1, 2021
2. Page JE, Walker S
Purification and cryoelectron microscopy structure determination of human V-ATPase.
1. STAR Protoc - published March 1, 2021
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iMATCH: an integrated modular assembly system for therapeutic combination high-capacity adenovirus gene therapy.
1. Mol Ther Methods Clin Dev - published March 1, 2021
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Crystal structure of the nonclassical cadherin-17 N-terminus and implications for its adhesive binding mechanism.
1. Acta Crystallogr F Struct Biol Commun - published March 1, 2021
2. Gray ME, Sotomayor M
eIF2B conformation and assembly state regulates the integrated stress response.
1. Elife - published March 1, 2021
2. Schoof M, Boone M, Wang L, Lawrence R, Frost A, Walter P
Cyclic Analogues of the Chemerin C-Terminus Mimic a Loop Conformation Essential for Activating the Chemokine-like Receptor 1.
1. J Med Chem - published March 1, 2021
2. Fischer TF, Schoeder CT, Zellmann T, Stichel J, Meiler J, Beck-Sickinger AG
The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication.
1. Elife - published March 1, 2021
2. Fatalska A, Stepinac E, Richter M, Kovacs L, Pietras Z, Puchinger M, Dong G, Dadlez M, Glover DM
A vulnerable, membrane-proximal site in human respiratory syncytial virus F revealed by a prefusion-specific single-domain antibody.
1. J Virol - published March 1, 2021
2. Rossey I, Hsieh CL, Sedeyn K, Ballegeer M, Schepens B, Mclellan JS, Saelens X
Coronavirus-Specific Antibody Cross Reactivity in Rhesus Macaques Following SARS-CoV-2 Vaccination and Infection.
1. J Virol - published March 1, 2021
2. Jacob-Dolan C, Feldman J, McMahan K, Yu J, Zahn R, Wegmann F, Schuitemaker H, Schmidt AG, Barouch DH
Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design.
1. Biochemistry - published March 1, 2021
2. Schoeder CT, Schmitz S, Adolf-Bryfogle J, Sevy AM, Finn JA, Sauer MF, Bozhanova NG, Mueller BK, Sangha AK, Bonet J, Sheehan JH, Kuenze G, Marlow B, Smith ST, Woods H, Bender BJ, Martina CE, Del Alamo D, Kodali P, Gulsevin A, Schief WR, Correia BE, Crowe JE Jr, Meiler J, Moretti R
Inhibition of CRISPR-Cas12a DNA targeting by nucleosomes and chromatin.
1. Sci Adv - published March 1, 2021
2. Strohkendl I, Saifuddin FA, Gibson BA, Rosen MK, Russell R, Finkelstein IJ
REGALS: a general method to deconvolve X-ray scattering data from evolving mixtures.
1. IUCrJ - published March 1, 2021
2. Meisburger SP, Xu D, Ando N
Protein Substrates Engage the Lumen of O-GlcNAc Transferase's Tetratricopeptide Repeat Domain in Different Ways.
1. Biochemistry - published March 1, 2021
2. Joiner CM, Hammel FA, Janetzko J, Walker S
Development of single-stranded DNA bisintercalating inhibitors of primase DnaG as antibiotics.
1. ChemMedChem - published March 1, 2021
2. Green KD, Punetha A, Chandrika NT, Hou C, Garneau-Tsodikova S, Tsodikov OV
Rapid tilt-series method for cryo-electron tomography: Characterizing stage behavior during FISE acquisition.
1. J Struct Biol - published March 1, 2021
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Differential cellular responses to adhesive interactions with galectin-8 and fibronectin coated substrates.
1. J Cell Sci - published March 1, 2021
2. Li W, Sancho A, Chung WL, Vinik Y, Groll J, Zick Y, Medalia O, Bershadsky AD, Geiger B
SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19.
1. Sci Transl Med - published March 1, 2021
2. Perez-Bermejo JA, Kang S, Rockwood SJ, Simoneau CR, Joy DA, Silva AC, Ramadoss GN, Flanigan WR, Fozouni P, Li H, Chen PY, Nakamura K, Whitman JD, Hanson PJ, McManus BM, Ott M, Conklin BR, McDevitt TC
In vitro characterization of engineered red blood cells as viral traps against HIV-1 and SARS-CoV-2.
1. Mol Ther Methods Clin Dev - published March 1, 2021
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Crystal structure of P. falciparum Cpn60 bound to ATP reveals an open dynamic conformation before substrate binding.
1. Sci Rep - published March 1, 2021
2. Nguyen B, Ma R, Tang WK, Shi D, Tolia NH
The Antifungal Drug Isavuconazole Inhibits the Replication of Human Cytomegalovirus (HCMV) and Acts Synergistically with Anti-HCMV Drugs.
1. Antiviral Res - published March 1, 2021
2. Mercorelli B, Celegato M, Luganini A, Gribaudo G, Lepesheva GI, Loregian A
Classical molecular dynamics.
1. J Chem Phys - published March 1, 2021
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A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection.
1. Cell Rep - published March 1, 2021
2. Kulsuptrakul J, Wang R, Meyers NL, Ott M, Puschnik AS
Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion.
1. J Med Chem - published March 1, 2021
2. Cockerill GS, Angell RM, Bedernjak A, Chuckowree I, Fraser I, Gascon-Simorte J, Gilman MSA, Good JAD, Harland R, Johnson SM, Ludes-Meyers JH, Littler E, Lumley J, Lunn G, Mathews N, McLellan JS, Paradowski M, Peeples ME, Scott C, Tait D, Taylor G, Thom M, Thomas E, Villalonga Barber C, Ward SE, Watterson D, Williams G, Young P, Powell K
Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes.
1. PLoS Biol - published March 1, 2021
2. Ravindra NG, Alfajaro MM, Gasque V, Huston NC, Wan H, Szigeti-Buck K, Yasumoto Y, Greaney AM, Habet V, Chow RD, Chen JS, Wei J, Filler RB, Wang B, Wang G, Niklason LE, Montgomery RR, Eisenbarth SC, Chen S, Williams A, Iwasaki A, Horvath TL, Foxman EF, Pierce RW, Pyle AM, van Dijk D, Wilen CB
Surface proteomics reveals CD72 as a target for in vitro-evolved nanobody-based CAR-T cells in KMT2A/MLL1-rearranged B-ALL.
1. Cancer Discov - published March 1, 2021
2. Nix MA, Mandal K, Geng H, Paranjape N, Lin YT, Rivera J, Marcoulis M, White KL, Whitman JD, Bapat SP, Parker KR, Ramirez J, Deucher A, Phojanokong P, Steri V, Fattahi F, Hann B, Satpathy AT, Manglik A, Stieglitz E, Wiita AP
Prediction of amphipathic helix-Membrane interactions with Rosetta.
1. PLoS Comput Biol - published March 1, 2021
2. Gulsevin A, Meiler J
Structural impact on SARS-CoV-2 spike protein by D614G substitution.
1. Science - published March 1, 2021
2. Zhang J, Cai Y, Xiao T, Lu J, Peng H, Sterling SM, Walsh RM Jr, Rits-Volloch S, Zhu H, Woosley AN, Yang W, Sliz P, Chen B
Author Correction: Self-assembly and regulation of protein cages from pre-organised coiled-coil modules.
1. Nat Commun - published March 1, 2021
2. Lapenta F, Aupič J, Vezzoli M, Strmšek Ž, Da Vela S, Svergun DI, Carazo JM, Melero R, Jerala R
DNA-driven condensation assembles the meiotic DNA break machinery.
1. Nature - published March 1, 2021
2. Claeys Bouuaert C, Pu S, Wang J, Oger C, Daccache D, Xie W, Patel DJ, Keeney S
Structure and gating mechanism of the α7 nicotinic acetylcholine receptor.
1. Cell - published March 1, 2021
2. Noviello CM, Gharpure A, Mukhtasimova N, Cabuco R, Baxter L, Borek D, Sine SM, Hibbs RE
A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies.
1. Nat Commun - published March 1, 2021
2. Wang C, van Haperen R, Gutiérrez-Álvarez J, Li W, Okba NMA, Albulescu I, Widjaja I, van Dieren B, Fernandez-Delgado R, Sola I, Hurdiss DL, Daramola O, Grosveld F, van Kuppeveld FJM, Haagmans BL, Enjuanes L, Drabek D, Bosch BJ
Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10.
1. Science - published March 1, 2021
2. Saxton RA, Tsutsumi N, Su LL, Abhiraman GC, Mohan K, Henneberg LT, Aduri NG, Gati C, Garcia KC
Facile Synthesis of a Croconaine-Based Nanoformulation for Optoacoustic Imaging and Photothermal Therapy.
1. Adv Healthc Mater - published March 1, 2021
2. Liu N, O'Connor P, Gujrati V, Gorpas D, Glasl S, Blutke A, Walch A, Kleigrewe K, Sattler M, Plettenburg O, Ntziachristos V
Phenotypic approaches to small-molecule discovery in chemical biology.
1. Cell Chem Biol - published March 1, 2021
2. Wagner BK, Dey M
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.
1. Cell - published March 1, 2021
2. Garcia-Beltran WF, Lam EC, St Denis K, Nitido AD, Garcia ZH, Hauser BM, Feldman J, Pavlovic MN, Gregory DJ, Poznansky MC, Sigal A, Schmidt AG, Iafrate AJ, Naranbhai V, Balazs AB
A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes.
1. Nat Commun - published March 1, 2021
2. Coelho CH, Tang WK, Burkhardt M, Galson JD, Muratova O, Salinas ND, Alves E Silva TL, Reiter K, MacDonald NJ, Nguyen V, Herrera R, Shimp R, Narum DL, Byrne-Steele M, Pan W, Hou X, Brown B, Eisenhower M, Han J, Jenkins BJ, Doritchamou JYA, Smelkinson MG, Vega-Rodríguez J, Trück J, Taylor JJ, Sagara I, Renn JP, Tolia NH, Duffy PE
The groovy TMEM16 family: molecular mechanisms of lipid scrambling and ion conduction.
1. J Mol Biol - published March 1, 2021
2. Kalienkova V, Clerico Mosina V, Paulino C
Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium.
1. Commun Biol - published March 1, 2021
2. Gandhi AK, Sun ZJ, Kim WM, Huang YH, Kondo Y, Bonsor DA, Sundberg EJ, Wagner G, Kuchroo VK, Petsko GA, Blumberg RS
Highlighting membrane protein structure and function: A celebration of the Protein Data Bank.
1. J Biol Chem - published March 1, 2021
2. Li F, Egea PF, Vecchio AJ, Asial I, Gupta M, Paulino J, Bajaj R, Dickinson MS, Ferguson-Miller S, Monk BC, Stroud RM
Integrating 3D structural information into systems biology.
1. J Biol Chem - published March 1, 2021
2. Murray D, Petrey D, Honig B
Free-Radical Membrane Protein Footprinting by Photolysis of Perfluoroisopropyl Iodide Partitioned to Detergent Micelle by Sonication.
1. Angew Chem Int Ed Engl - published March 1, 2021
2. Cheng M, Guo C, Li W, Gross ML
A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques.
1. Cell Rep Med - published March 1, 2021
2. Hassan AO, Feldmann F, Zhao H, Curiel DT, Okumura A, Tang-Huau TL, Case JB, Meade-White K, Callison J, Chen RE, Lovaglio J, Hanley PW, Scott DP, Fremont DH, Feldmann H, Diamond MS
Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies.
1. bioRxiv - published March 1, 2021
2. Greaney AJ, Starr TN, Barnes CO, Weisblum Y, Schmidt F, Caskey M, Gaebler C, Cho A, Agudelo M, Finkin S, Wang Z, Poston D, Muecksch F, Hatziioannou T, Bieniasz PD, Robbiani DF, Nussenzweig MC, Bjorkman PJ, Bloom JD
Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike.
1. bioRxiv - published March 1, 2021
2. Tong P, Gautam A, Windsor I, Travers M, Chen Y, Garcia N, Whiteman NB, McKay LGA, Lelis FJN, Habibi S, Cai Y, Rennick LJ, Duprex WP, McCarthy KR, Lavine CL, Zuo T, Lin J, Zuiani A, Feldman J, MacDonald EA, Hauser BM, Griffths A, Seaman MS, Schmidt AG, Chen B, Neuberg D, Bajic G, Harrison SC, Wesemann DR
Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry.
1. PLoS Pathog - published March 1, 2021
2. Ren W, Zhu Y, Wang Y, Shi H, Yu Y, Hu G, Feng F, Zhao X, Lan J, Wu J, Kenney DJ, Douam F, Tong Y, Zhong J, Xie Y, Wang X, Yuan Z, Zhou D, Zhang R, Ding Q
Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein.
1. Cell - published March 1, 2021
2. Suryadevara N, Shrihari S, Gilchuk P, VanBlargan LA, Binshtein E, Zost SJ, Nargi RS, Sutton RE, Winkler ES, Chen EC, Fouch ME, Davidson E, Doranz BJ, Chen RE, Shi PY, Carnahan RH, Thackray LB, Diamond MS, Crowe JE Jr
Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase.
1. Cell Chem Biol - published March 1, 2021
2. Dawson CD, Irwin SM, Backman LRF, Le C, Wang JX, Vennelakanti V, Yang Z, Kulik HJ, Drennan CL, Balskus EP
Odontoblast TRPC5 channels signal cold pain in teeth.
1. Sci Adv - published March 1, 2021
2. Bernal L, Sotelo-Hitschfeld P, König C, Sinica V, Wyatt A, Winter Z, Hein A, Touska F, Reinhardt S, Tragl A, Kusuda R, Wartenberg P, Sclaroff A, Pfeifer JD, Ectors F, Dahl A, Freichel M, Vlachova V, Brauchi S, Roza C, Boehm U, Clapham DE, Lennerz JK, Zimmermann K
A cryo-electron tomography workflow reveals protrusion-mediated shedding on injured plasma membrane.
1. Sci Adv - published March 1, 2021
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Microcrystal Electron Diffraction of Small Molecules.
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Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite.
1. Cell Host Microbe - published March 1, 2021
2. Cerutti G, Guo Y, Zhou T, Gorman J, Lee M, Rapp M, Reddem ER, Yu J, Bahna F, Bimela J, Huang Y, Katsamba PS, Liu L, Nair MS, Rawi R, Olia AS, Wang P, Zhang B, Chuang GY, Ho DD, Sheng Z, Kwong PD, Shapiro L
Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class.
1. Cell Rep - published March 1, 2021
2. Rapp M, Guo Y, Reddem ER, Yu J, Liu L, Wang P, Cerutti G, Katsamba P, Bimela JS, Bahna FA, Mannepalli SM, Zhang B, Kwong PD, Huang Y, Ho DD, Shapiro L, Sheng Z
Design of Alphavirus Virus-Like Particles Presenting Circumsporozoite Junctional Epitopes That Elicit Protection against Malaria.
1. Vaccines (Basel) - published March 1, 2021
2. Francica JR, Shi W, Chuang GY, Chen SJ, Da Silva Pereira L, Farney SK, Flynn BJ, Ou L, Stephens T, Tsybovsky Y, Wang LT, Anderson A, Beck Z, Dillon M, Idris AH, Hurlburt N, Liu T, Zhang B, Alving CR, Matyas GR, Pancera M, Mascola JR, Kwong PD, Seder RA
A Crisis-Responsive Framework for Medical Device Development Applied to the COVID-19 Pandemic.
1. Front Digit Health - published March 1, 2021
2. Antonini MJ, Plana D, Srinivasan S, Atta L, Achanta A, Yang H, Cramer AK, Freake J, Sinha MS, Yu SH, LeBoeuf NR, Linville-Engler B, Sorger PK
A PyMOL snippet library for Jupyter to boost researcher productivity.
1. Comput Sci Eng - published March 1, 2021
2. Mooers BHM
Acyl metalloids: conformity and deviation from carbonyl reactivity.
1. Chem Sci - published March 1, 2021
2. Holownia A, Apte CN, Yudin AK