Member Publications

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132 Member Publications for December 2020

In Situ Imaging and Structure Determination of Biomolecular Complexes Using Electron Cryo-Tomography.
1. Methods Mol Biol - published December 28, 2020
2. Kaplan M, Nicolas WJ, Zhao W, Carter SD, Metskas LA, Chreifi G, Ghosal D, Jensen GJ
A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms.
1. J Biol Chem - published December 25, 2020
2. Stefano JE, Lord DM, Zhou Y, Jaworski J, Hopke J, Travaline T, Zhang N, Wong K, Lennon A, He T, Bric-Furlong E, Cherrie C, Magnay T, Remy E, Brondyk W, Qiu H, Radošević K
IPSE, a parasite-derived, host immunomodulatory infiltrin protein, alleviates resiniferatoxin-induced bladder pain.
1. Mol Pain - published December 21, 2020
2. Ishida K, Mbanefo EC, Le L, Lamanna O, Pennington LF, Finkel JC, Jardetzky TS, Falcone FH, Hsieh MH
IGFLR1 as a Novel Prognostic Biomarker in Clear Cell Renal Cell Cancer Correlating With Immune Infiltrates.
1. Front Mol Biosci - published December 16, 2020
2. Song W, Shao Y, He X, Gong P, Yang Y, Huang S, Zeng Y, Wei L, Zhang J
Corrigendum: The Effects of Framework Mutations at the Variable Domain Interface on Antibody Affinity Maturation in an HIV-1 Broadly Neutralizing Antibody Lineage.
1. Front Immunol - published December 14, 2020
2. Zhou JO, Zaidi HA, Ton T, Fera D
In Vitro Primer-Based RNA Elongation and Promoter Fine Mapping of the Respiratory Syncytial Virus.
1. J Virol - published December 9, 2020
2. Cao D, Gao Y, Roesler C, Rice S, D'Cunha P, Zhuang L, Slack J, Antonova A, Romanelli S, Liang B
Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity.
1. J Biol Chem - published December 9, 2020
2. Wang Y, Hou L, Ardehali MB, Kingston RE, Dynlacht BD
IPSE, a urogenital parasite-derived immunomodulatory molecule, suppresses bladder pathogenesis and anti-microbial peptide gene expression in bacterial urinary tract infection.
1. Parasit Vectors - published December 9, 2020
2. Mbanefo EC, Le L, Pennington LF, Hsieh YJ, Odegaard JI, Lapira K, Jardetzky TS, Falcone FH, Hsieh MH
Lymphoangiocrine signals promote cardiac growth and repair.
1. Nature - published December 9, 2020
2. Liu X, De la Cruz E, Gu X, Balint L, Oxendine-Burns M, Terrones T, Ma W, Kuo HH, Lantz C, Bansal T, Thorp E, Burridge P, Jakus Z, Herz J, Cleaver O, Torres M, Oliver G
Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin.
1. Nucleic Acids Res - published December 9, 2020
2. Bacolla A, Sengupta S, Ye Z, Yang C, Mitra J, De-Paula RB, Hegde ML, Ahmed Z, Mort M, Cooper DN, Mitra S, Tainer JA
Single cell RNA-seq of psoriatic skin identifies pathogenic Tc17 subsets and reveals distinctions between CD8⁺ T cells in autoimmunity and cancer.
1. J Allergy Clin Immunol - published December 9, 2020
2. Liu J, Chang HW, Huang ZM, Nakamura M, Sekhon S, Ahn R, Munoz-Sandoval P, Bhattarai S, Beck KM, Sanchez IM, Yang E, Pauli M, Arron ST, Fung-Leung WP, Munoz E, Liu X, Bhutani T, North J, Fourie AM, Rosenblum MD, Liao W
Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting.
1. Mol Cell - published December 9, 2020
2. Komolov KE, Sulon SM, Bhardwaj A, van Keulen SC, Duc NM, Laurinavichyute DK, Lou HJ, Turk BE, Chung KY, Dror RO, Benovic JL
Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses.
1. Cell - published December 9, 2020
2. Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano KA, Hayashi JM, Carlson-Stevermer J, Zengel JR, Richards CM, Fozouni P, Oki J, Rodriguez L, Joehnk B, Walcott K, Holden K, Sil A, Carette JE, Krogan NJ, Ott M, Puschnik AS
RV144 HIV-1 vaccination impacts post-infection antibody responses.
1. PLoS Pathog - published December 8, 2020
2. Mdluli T, Jian N, Slike B, Paquin-Proulx D, Donofrio G, Alrubayyi A, Gift S, Grande R, Bryson M, Lee A, Dussupt V, Mendez-Riveria L, Sanders-Buell E, Chenine AL, Tran U, Li Y, Brown E, Edlefsen PT, O'Connell R, Gilbert P, Nitayaphan S, Pitisuttihum P, Rerks-Ngarm S, Robb ML, Gramzinski R, Alter G, Tovanabutra S, Georgiev IS, Ackerman ME, Polonis VR, Vasan S, Michael NL, Kim JH, Eller MA, Krebs SJ, Rolland M
Flanking sequence preference modulates de novo DNA methylation in the mouse genome.
1. Nucleic Acids Res - published December 8, 2020
2. Mallona I, Ilie IM, Karemaker ID, Butz S, Manzo M, Caflisch A, Baubec T
MicroED structure of lipid-embedded mammalian mitochondrial voltage-dependent anion channel.
1. Proc Natl Acad Sci U S A - published December 8, 2020
2. Martynowycz MW, Khan F, Hattne J, Abramson J, Gonen T
The multifaceted functions of RNA helicases in the adaptive cellular response to hypoxia: From mechanisms to therapeutics.
1. Pharmacol Ther - published December 8, 2020
2. Wang Y, Li G, Deng M, Liu X, Huang W, Zhang Y, Liu M, Chen Y
Dissecting the Structural Dynamics of the Nuclear Pore Complex.
1. Mol Cell - published December 8, 2020
2. Hakhverdyan Z, Molloy KR, Keegan S, Herricks T, Lepore DM, Munson M, Subbotin RI, Fenyö D, Aitchison JD, Fernandez-Martinez J, Chait BT, Rout MP
Supramolecular Architecture through Self-Organization of Janus-Faced Homoazanucleosides.
1. J Org Chem - published December 7, 2020
2. Mishra UK, Sanghvi YS, Egli M, Ramesh NG
Flagellar Structures from the Bacterium Caulobacter crescentus and Implications for Phage ΦCbK Predation of Multi-Flagellin Bacteria.
1. J Bacteriol - published December 7, 2020
2. Montemayor EJ, Ploscariu NT, Sanchez JC, Parrell D, Dillard RS, Shebelut CW, Ke Z, Guerrero-Ferreira RC, Wright ER
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.
1. Nat Chem Biol - published December 7, 2020
2. Liwocha J, Krist DT, van der Heden van Noort GJ, Hansen FM, Truong VH, Karayel O, Purser N, Houston D, Burton N, Bostock MJ, Sattler M, Mann M, Harrison JS, Kleiger G, Ovaa H, Schulman BA
Enhanced SARS-CoV-2 neutralization by dimeric IgA.
1. Sci Transl Med - published December 7, 2020
2. Wang Z, Lorenzi JCC, Muecksch F, Finkin S, Viant C, Gaebler C, Cipolla M, Hoffmann HH, Oliveira TY, Oren DA, Ramos V, Nogueira L, Michailidis E, Robbiani DF, Gazumyan A, Rice CM, Hatziioannou T, Bieniasz PD, Caskey M, Nussenzweig MC
Membrane Remodeling: ESCRT-III Filaments as Molecular Garrotes.
1. Curr Biol - published December 7, 2020
2. McCullough J, Sundquist WI
Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome.
1. Sci Immunol - published December 7, 2020
2. Röltgen K, Powell AE, Wirz OF, Stevens BA, Hogan CA, Najeeb J, Hunter M, Wang H, Sahoo MK, Huang C, Yamamoto F, Manohar M, Manalac J, Otrelo-Cardoso AR, Pham TD, Rustagi A, Rogers AJ, Shah NH, Blish CA, Cochran JR, Jardetzky TS, Zehnder JL, Wang TT, Narasimhan B, Gombar S, Tibshirani R, Nadeau KC, Kim PS, Pinsky BA, Boyd SD
A Conformational Change in the N Terminus of SLC38A9 Signals mTORC1 Activation.
1. Structure - published December 7, 2020
2. Lei HT, Mu X, Hattne J, Gonen T
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity.
1. Cell - published December 7, 2020
2. Ringel AE, Drijvers JM, Baker GJ, Catozzi A, García-Cañaveras JC, Gassaway BM, Miller BC, Juneja VR, Nguyen TH, Joshi S, Yao CH, Yoon H, Sage PT, LaFleur MW, Trombley JD, Jacobson CA, Maliga Z, Gygi SP, Sorger PK, Rabinowitz JD, Sharpe AH, Haigis MC
Characterization of novel neutralizing mouse monoclonal antibody JM1-24-3 developed against MUC18 in metastatic melanoma.
1. J Exp Clin Cancer Res - published December 5, 2020
2. Feng R, Wang Y, Ramachandran V, Ma Q, May MM, Li M, Zhou JX, Xu X, Xu K, Fang S, Xia W, Sui D, Liu H, Gao X, Prieto V, Blacklow SC, Lu M, Lee JE
Targeting MDM2 for Neuroblastoma Therapy: In Vitro and In Vivo Anticancer Activity and Mechanism of Action.
1. Cancers (Basel) - published December 5, 2020
2. Wang W, Wang X, Rajaei M, Youn JY, Zafar A, Deokar H, Buolamwini JK, Yang J, Foster JH, Zhou J, Zhang R
Embryonic Stem-Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK.
1. Dev Cell - published December 5, 2020
2. Hur YH, Feng S, Wilson KF, Cerione RA, Antonyak MA
Activation of the archaeal ion channel MthK is exquisitely regulated by temperature.
1. Elife - published December 4, 2020
2. Jiang Y, Idikuda V, Chowdhury S, Chanda B
Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ.
1. Science - published December 4, 2020
2. Martin R, Qi T, Zhang H, Liu F, King M, Toth C, Nogales E, Staskawicz BJ
Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses.
1. ACS Infect Dis - published December 4, 2020
2. Bajic G, Harrison SC
Experiences with offering pro bono medical genetics services in the West Indies: Benefits to patients, physicians, and the community.
1. Am J Med Genet C Semin Med Genet - published December 4, 2020
2. Sobering AK, Li D, Beighley JS, Carey JC, Donald T, Elsea SH, Figueroa KP, Gerdts J, Hamlet A, Mirzaa GM, Nelson B, Pulst SM, Smith JL, Tassone F, Toriello HV, Walker RH, Yearwood KR, Bhoj EJ
The surface lipoproteins of Gram-negative bacteria: protectors and foragers in harsh environments.
1. J Biol Chem - published December 4, 2020
2. Cole GB, Bateman TJ, Moraes TF
Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina.
1. Nat Commun - published December 4, 2020
2. Sapra KT, Qin Z, Dubrovsky-Gaupp A, Aebi U, Müller DJ, Buehler MJ, Medalia O
Integrative modeling of membrane-associated protein assemblies.
1. Nat Commun - published December 4, 2020
2. Roel-Touris J, Jiménez-García B, Bonvin AMJJ
A substrate binding model for the KEOPS tRNA modifying complex.
1. Nat Commun - published December 4, 2020
2. Beenstock J, Ona SM, Porat J, Orlicky S, Wan LCK, Ceccarelli DF, Maisonneuve P, Szilard RK, Yin Z, Setiaputra D, Mao DYL, Khan M, Raval S, Schriemer DC, Bayfield MA, Durocher D, Sicheri F
Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection.
1. Cell - published December 4, 2020
2. Williamson LE, Gilliland T Jr, Yadav PK, Binshtein E, Bombardi R, Kose N, Nargi RS, Sutton RE, Durie CL, Armstrong E, Carnahan RH, Walker LM, Kim AS, Fox JM, Diamond MS, Ohi MD, Klimstra WB, Crowe JE Jr
¹H, ¹³C, and ¹⁵N backbone chemical shift assignments of the C-terminal dimerization domain of SARS-CoV-2 nucleocapsid protein.
1. Biomol NMR Assign - published December 3, 2020
2. Korn SM, Lambertz R, Fürtig B, Hengesbach M, Löhr F, Richter C, Schwalbe H, Weigand JE, Wöhnert J, Schlundt A
The catalytic mechanism of vitamin K epoxide reduction in a cellular environment.
1. J Biol Chem - published December 3, 2020
2. Shen G, Cui W, Cao Q, Gao M, Liu H, Su G, Gross ML, Li W
Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology.
1. Cell Stem Cell - published December 3, 2020
2. Simoneau CR, Ott M
Coexpressed subunits of dual genetic origin define a conserved supercomplex mediating essential protein import into chloroplasts.
1. Proc Natl Acad Sci U S A - published December 3, 2020
2. Ramundo S, Asakura Y, Salomé PA, Strenkert D, Boone M, Mackinder LCM, Takafuji K, Dinc E, Rahire M, Crèvecoeur M, Magneschi L, Schaad O, Hippler M, Jonikas MC, Merchant S, Nakai M, Rochaix JD, Walter P
Author Correction: The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma.
1. Nat Struct Mol Biol - published December 3, 2020
2. McBride MJ, Mashtalir N, Winter EB, Dao HT, Filipovski M, D'Avino AR, Seo HS, Umbreit NT, St Pierre R, Valencia AM, Qian K, Zullow HJ, Jaffe JD, Dhe-Paganon S, Muir TW, Kadoch C
Identification and Characterization of a B-Raf Kinase α-Helix Critical for the Activity of MEK Kinase in MAPK Signaling.
1. Biochemistry - published December 3, 2020
2. Nguyen D, Lin LY, Zhou JO, Kibby E, Sia TW, Tillis TD, Vapuryan N, Xu MR, Potluri R, Shin Y, Erler EA, Bronkema N, Boehlmer DJ, Chung CD, Burkhard C, Zeng SH, Grasso M, Acevedo LA, Marmorstein R, Fera D
Structure of a Stable Interstrand DNA Cross-Link Involving a β-N-Glycosyl Linkage Between an N⁶-dA Amino Group and an Abasic Site.
1. Biochemistry - published December 3, 2020
2. Kellum AH Jr, Qiu DY, Voehler MW, Martin W, Gates KS, Stone MP
Gain-of-function variant p.Pro2555Arg of von Willebrand factor increases aggregate size through altering stem dynamics.
1. Thromb Haemost - published December 3, 2020
2. Huck V, Chen PC, Xu ER, Tischer A, Klemm U, Aponte-Santamaría C, Mess C, Obser T, Kutzki F, König G, Denis C, Gräter F, Wilmanns M, Auton M, Schneider SW, Schneppenheim R, Hennig J, Brehm MA
An eight amino acid segment controls oligomerization and preferred conformation of the two non-visual arrestins.
1. J Mol Biol - published December 3, 2020
2. Chen Q, Zhuo Y, Sharma P, Perez I, Francis DJ, Chakravarthy S, Vishnivetskiy SA, Berndt S, Hanson SM, Zhan X, Brooks EK, Altenbach C, Hubbell WL, Klug CS, Iverson TM, Gurevich VV
CARM1 regulates replication fork speed and stress response by stimulating PARP1.
1. Mol Cell - published December 3, 2020
2. Genois MM, Gagné JP, Yasuhara T, Jackson J, Saxena S, Langelier MF, Ahel I, Bedford MT, Pascal JM, Vindigni A, Poirier GG, Zou L
The topology of chromatin-binding domains in the NuRD deacetylase complex.
1. Nucleic Acids Res - published December 2, 2020
2. Millard CJ, Fairall L, Ragan TJ, Savva CG, Schwabe JWR
ADP-ribosylation of histone variant H2AX promotes base excision repair.
1. EMBO J - published December 2, 2020
2. Chen Q, Bian C, Wang X, Liu X, Ahmad Kassab M, Yu Y, Yu X
A nanobody suite for yeast scaffold nucleoporins provides details of the nuclear pore complex structure.
1. Nat Commun - published December 2, 2020
2. Nordeen SA, Andersen KR, Knockenhauer KE, Ingram JR, Ploegh HL, Schwartz TU
The global and local distribution of RNA structure throughout the SARS-CoV-2 genome.
1. J Virol - published December 2, 2020
2. Tavares RCA, Mahadeshwar G, Wan H, Huston NC, Pyle AM
Allosteric Interference in Oncogenic FLI1 and ERG Transactions by Mithramycins.
1. Structure - published December 2, 2020
2. Hou C, Mandal A, Rohr J, Tsodikov OV
Pseudomonas aeruginosa survives in epithelia by ExoS-mediated inhibition of autophagy and mTOR.
1. EMBO Rep - published December 2, 2020
2. Rao L, De La Rosa I, Xu Y, Sha Y, Bhattacharya A, Holtzman MJ, Gilbert BE, Eissa NT
CD11c regulates hematopoietic stem and progenitor cells under stress.
1. Blood Adv - published December 2, 2020
2. Hou L, Voit RA, Sankaran VG, Springer TA, Yuki K
BCL::Conf: Improved Open-Source Knowledge-Based Conformation Sampling Using the Crystallography Open Database.
1. J Chem Inf Model - published December 2, 2020
2. Mendenhall J, Brown BP, Kothiwale S, Meiler J
Risk factors associated with 28-day all-cause mortality in older severe COVID-19 patients in Wuhan, China: a retrospective observational study.
1. Sci Rep - published December 2, 2020
2. Jiang Y, Abudurexiti S, An MM, Cao D, Wei J, Gong P
Gated Proton Release during Radical Transfer at the Subunit Interface of Ribonucleotide Reductase.
1. J Am Chem Soc - published December 2, 2020
2. Cui C, Greene BL, Kang G, Drennan CL, Stubbe J, Nocera DG
Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction.
1. Nat Commun - published December 2, 2020
2. Fäßler F, Dimchev G, Hodirnau VV, Wan W, Schur FKM
Lipid-based vaccine nanoparticles for induction of humoral immune responses against HIV-1 and SARS-CoV-2.
1. J Control Release - published December 2, 2020
2. Park KS, Bazzill JD, Son S, Nam J, Shin SW, Ochyl LJ, Stuckey JA, Meagher JL, Chang L, Song J, Montefiori DC, LaBranche CC, Smith JL, Xu J, Moon JJ
Cryo-EM structure of Vibrio cholerae aldehyde-alcohol dehydrogenase spirosomes.
1. Biochem Biophys Res Commun - published December 2, 2020
2. Cho S, Kim G, Song JJ, Cho C
Biochemical and crystallographic investigations into isonitrile formation by a non-heme iron-dependent oxidase/decarboxylase.
1. J Biol Chem - published December 2, 2020
2. Jonnalagadda R, Del Rio Flores A, Cai W, Mehmood R, Narayanamoorthy M, Ren C, Zaragoza JPT, Kulik HJ, Zhang W, Drennan CL
Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.
1. Nature - published December 2, 2020
2. Li W, Tian W, Yuan G, Deng P, Sengupta D, Cheng Z, Cao Y, Ren J, Qin Y, Zhou Y, Jia Y, Gozani O, Patel DJ, Wang Z
Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ.
1. Cell - published December 2, 2020
2. Cappelletti V, Hauser T, Piazza I, Pepelnjak M, Malinovska L, Fuhrer T, Li Y, Dörig C, Boersema P, Gillet L, Grossbach J, Dugourd A, Saez-Rodriguez J, Beyer A, Zamboni N, Caflisch A, de Souza N, Picotti P
Phase Separation as a Missing Mechanism for Interpretation of Disease Mutations.
1. Cell - published December 2, 2020
2. Tsang B, Pritišanac I, Scherer SW, Moses AM, Forman-Kay JD
Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.
1. PLoS Biol - published December 2, 2020
2. Lu TW, Aoto PC, Weng JH, Nielsen C, Cash JN, Hall J, Zhang P, Simon SM, Cianfrocco MA, Taylor SS
Surface tensiometry of phase separated protein and polymer droplets by the sessile drop method.
1. Soft Matter - published December 2, 2020
2. Ijavi M, Style RW, Emmanouilidis L, Kumar A, Meier SM, Torzynski AL, Allain FHT, Barral Y, Steinmetz MO, Dufresne ER
Autoantibodies as Endogenous Modulators of GPCR Signaling.
1. Trends Pharmacol Sci - published December 2, 2020
2. Skiba MA, Kruse AC
Opposite Surfaces of the Cdc15 F-BAR Domain Create a Membrane Platform That Coordinates Cytoskeletal and Signaling Components for Cytokinesis.
1. Cell Rep - published December 2, 2020
2. Snider CE, Chandra M, McDonald NA, Willet AH, Collier SE, Ohi MD, Jackson LP, Gould KL
Methylguanidinium at the Air/Water Interface: A Simulation Study with the Drude Polarizable Force Field.
1. J Phys Chem B - published December 2, 2020
2. Zhu J, Huang J
De Novo Design, Solution Characterization, and Crystallographic Structure of an Abiological Mn-Porphyrin-Binding Protein Capable of Stabilizing a Mn(V) Species.
1. J Am Chem Soc - published December 2, 2020
2. Mann SI, Nayak A, Gassner GT, Therien MJ, DeGrado WF
Efficient Sampling of Protein Loop Regions Using Conformational Hashing Complemented with Random Coordinate Descent.
1. J Chem Theory Comput - published December 2, 2020
2. Del Alamo D, Fischer AW, Moretti R, Alexander NS, Mendenhall J, Hyman NJ, Meiler J
Global Genome Demethylation Causes Transcription-Associated DNA Double Strand Breaks in HPV-Associated Head and Neck Cancer Cells.
1. Cancers (Basel) - published December 2, 2020
2. Hajek M, Biktasova A, Sewell A, Gary C, Cantalupo P, Anderson KS, Yarbrough WG, Issaeva N
Structural analysis of Mycobacteriumtuberculosis M13 metalloprotease Zmp1 open states.
1. Structure - published December 2, 2020
2. Liang WG, Mancl JM, Zhao M, Tang WJ
Poxviral Strategies to Overcome Host Cell Apoptosis.
1. Pathogens - published December 2, 2020
2. Suraweera CD, Hinds MG, Kvansakul M
SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma.
1. bioRxiv - published December 2, 2020
2. Andreano E, Piccini G, Licastro D, Casalino L, Johnson NV, Paciello I, Dal Monego S, Pantano E, Manganaro N, Manenti A, Manna R, Casa E, Hyseni I, Benincasa L, Montomoli E, Amaro RE, McLellan JS, Rappuoli R
D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction.
1. Cell Rep - published December 2, 2020
2. Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Manne K, Stalls V, Kopp MF, Henderson R, Edwards RJ, Haynes BF, Acharya P
Histone chaperone FACT FAcilitates Chromatin Transcription: mechanistic and structural insights.
1. Curr Opin Struct Biol - published December 1, 2020
2. Zhou K, Liu Y, Luger K
Nuclear Imaging of Bacterial Infection: The State of the Art and Future Directions.
1. J Nucl Med - published December 1, 2020
2. Polvoy I, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM
Regulatory and Safety Considerations in Deploying a Locally Fabricated, Reusable Face Shield in a Hospital Responding to the COVID-19 Pandemic.
1. Med (N Y) - published December 1, 2020
2. Mostaghimi A, Antonini MJ, Plana D, Anderson PD, Beller B, Boyer EW, Fannin A, Freake J, Oakley R, Sinha MS, Smith L, Van C, Yang H, Sorger PK, LeBoeuf NR, Yu SH
Clinical validation of a Cas13-based assay for the detection of SARS-CoV-2 RNA.
1. Nat Biomed Eng - published December 1, 2020
2. Patchsung M, Jantarug K, Pattama A, Aphicho K, Suraritdechachai S, Meesawat P, Sappakhaw K, Leelahakorn N, Ruenkam T, Wongsatit T, Athipanyasilp N, Eiamthong B, Lakkanasirorat B, Phoodokmai T, Niljianskul N, Pakotiprapha D, Chanarat S, Homchan A, Tinikul R, Kamutira P, Phiwkaow K, Soithongcharoen S, Kantiwiriyawanitch C, Pongsupasa V, Trisrivirat D, Jaroensuk J, Wongnate T, Maenpuen S, Chaiyen P, Kamnerdnakta S, Swangsri J, Chuthapisith S, Sirivatanauksorn Y, Chaimayo C, Sutthent R, Kantakamalakul W, Joung J, Ladha A, Jin X, Gootenberg JS, Abudayyeh OO, Zhang F, Horthongkham N, Uttamapinant C
Stoichiometry of Nucleotide Binding to Proteasome AAA+ ATPase Hexamer Established by Native Mass Spectrometry.
1. Mol Cell Proteomics - published December 1, 2020
2. Yu Y, Liu H, Yu Z, Witkowska HE, Cheng Y
The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia.
1. Nat Struct Mol Biol - published December 1, 2020
2. Titus EW, Deiter FH, Shi C, Wojciak J, Scheinman M, Jura N, Deo RC
Repurposing Nucleoside Analogs for Human Coronaviruses.
1. Antimicrob Agents Chemother - published December 1, 2020
2. Zandi K, Amblard F, Musall K, Downs-Bowen J, Kleinbard R, Oo A, Cao D, Liang B, Russell OO, McBrayer T, Bassit L, Kim B, Schinazi RF
Nucleotide analogues as inhibitors of SARS-CoV Polymerase.
1. Pharmacol Res Perspect - published December 1, 2020
2. Ju J, Li X, Kumar S, Jockusch S, Chien M, Tao C, Morozova I, Kalachikov S, Kirchdoerfer RN, Russo JJ
The conformational cycle of a prototypical voltage-gated sodium channel.
1. Nat Chem Biol - published December 1, 2020
2. Catterall WA, Wisedchaisri G, Zheng N
Iminoboronates as dual purpose linkers in chemical probe development.
1. Chemistry - published December 1, 2020
2. van der Zouwen AJN, Jeucken A, Steneker R, Hohmann KF, Lohse J, Slotboom DJ, Witte M
Small molecule cognitive enhancer reverses age-related memory decline in mice.
1. Elife - published December 1, 2020
2. Krukowski K, Nolan A, Frias ES, Boone M, Ureta G, Grue K, Paladini MS, Elizarraras E, Delgado L, Bernales S, Walter P, Rosi S
Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development.
1. Cell - published December 1, 2020
2. Donovan KA, Ferguson FM, Bushman JW, Eleuteri NA, Bhunia D, Ryu S, Tan L, Shi K, Yue H, Liu X, Dobrovolsky D, Jiang B, Wang J, Hao M, You I, Teng M, Liang Y, Hatcher J, Li Z, Manz TD, Groendyke B, Hu W, Nam Y, Sengupta S, Cho H, Shin I, Agius MP, Ghobrial IM, Ma MW, Che J, Buhrlage SJ, Sim T, Gray NS, Fischer ES
Herpes simplex virus 2 encephalitis in a patient heterozygous for a TLR3 mutation.
1. Neurol Genet - published December 1, 2020
2. Hautala T, Chen J, Tervonen L, Partanen T, Winqvist S, Lehtonen J, Saarela J, Kraatari M, Kuismin O, Vuorinen T, Glumoff V, Åström P, Huuskonen U, Lorenzo L, Casanova JL, Zhang SY, Seppänen MRJ
Pre-termination Transcription Complex: Structure and Function.
1. Mol Cell - published December 1, 2020
2. Hao Z, Epshtein V, Kim KH, Proshkin S, Svetlov V, Kamarthapu V, Bharati B, Mironov A, Walz T, Nudler E
Assessment of Trends in Second Primary Cancers in Patients With Metastatic Melanoma From 2005 to 2016.
1. JAMA Netw Open - published December 1, 2020
2. Deng W, Wang Y, Liu X, Liu J, Wang L, Yang Z, Yang M, An Y, Tang C, Sanford NN, Kim BYS, Jiang W
Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates.
1. J Am Chem Soc - published December 1, 2020
2. Boyce JH, Dang B, Ary B, Edmondson Q, Craik CS, DeGrado WF, Seiple IB
Visualizing insulin vesicle neighborhoods in β cells by cryo-electron tomography.
1. Sci Adv - published December 1, 2020
2. Zhang X, Carter SD, Singla J, White KL, Butler PC, Stevens RC, Jensen GJ
Nuclear import of histones.
1. Biochem Soc Trans - published December 1, 2020
2. Bernardes NE, Chook YM
Murine double minute 2 inhibition alone or with cytarabine in acute myeloid leukemia: Results from an idasanutlin phase 1/1b study⋆.
1. Leuk Res - published December 1, 2020
2. Yee K, Papayannidis C, Vey N, Dickinson MJ, Kelly KR, Assouline S, Kasner M, Seiter K, Drummond MW, Yoon SS, Lee JH, Blotner S, Jukofsky L, Pierceall WE, Zhi J, Simon S, Higgins B, Nichols G, Monnet A, Muehlbauer S, Ott M, Chen LC, Martinelli G
Genetic interaction mapping informs integrative structure determination of protein complexes.
1. Science - published December 1, 2020
2. Braberg H, Echeverria I, Bohn S, Cimermancic P, Shiver A, Alexander R, Xu J, Shales M, Dronamraju R, Jiang S, Dwivedi G, Bogdanoff D, Chaung KK, Hüttenhain R, Wang S, Mavor D, Pellarin R, Schneidman D, Bader JS, Fraser JS, Morris J, Haber JE, Strahl BD, Gross CA, Dai J, Boeke JD, Sali A, Krogan NJ
Potent Henipavirus Neutralization by Antibodies Recognizing Diverse Sites on Hendra and Nipah Virus Receptor Binding Protein.
1. Cell - published December 1, 2020
2. Dong J, Cross RW, Doyle MP, Kose N, Mousa JJ, Annand EJ, Borisevich V, Agans KN, Sutton R, Nargi R, Majedi M, Fenton KA, Reichard W, Bombardi RG, Geisbert TW, Crowe JE Jr
An improved fluorescent tag and its nanobodies for membrane protein expression, stability assay, and purification.
1. Commun Biol - published December 1, 2020
2. Cai H, Yao H, Li T, Hutter CAJ, Li Y, Tang Y, Seeger MA, Li D
Author Correction: Senescent cells promote tissue NAD⁺ decline during ageing via the activation of CD38⁺ macrophages.
1. Nat Metab - published December 1, 2020
2. Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E
D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization.
1. Cell Host Microbe - published December 1, 2020
2. Weissman D, Alameh MG, de Silva T, Collini P, Hornsby H, Brown R, LaBranche CC, Edwards RJ, Sutherland L, Santra S, Mansouri K, Gobeil S, McDanal C, Pardi N, Hengartner N, Lin PJC, Tam Y, Shaw PA, Lewis MG, Boesler C, Şahin U, Acharya P, Haynes BF, Korber B, Montefiori DC
Spike glycoprotein and host cell determinants of SARS-CoV-2 entry and cytopathic effects.
1. J Virol - published December 1, 2020
2. Nguyen HT, Zhang S, Wang Q, Anang S, Wang J, Ding H, Kappes JC, Sodroski J
Mutant huntingtin is cleared from the brain via active mechanisms in Huntington disease.
1. J Neurosci - published December 1, 2020
2. Caron NS, Banos R, Yanick C, Aly AE, Byrne LM, Smith ED, Xie Y, Smith SEP, Potluri N, Findlay Black H, Casal L, Ko S, Cheung D, Kim H, Seong IS, Wild EJ, Song JJ, Hayden MR, Southwell AL
Exploring the Ligand Preferences of the PHD1 Domain of Histone Demethylase KDM5A Reveals Tolerance for Modifications of the Q5 Residue of Histone 3.
1. ACS Chem Biol - published December 1, 2020
2. Anderson SE, Longbotham JE, O'Kane PT, Ugur FS, Fujimori DG, Mrksich M
Mechanisms of ligand binding.
1. Biophys Rev - published December 1, 2020
2. Di Cera E
Second sialic acid-binding site of influenza A virus neuraminidase: Binding receptors for efficient release.
1. FEBS J - published December 1, 2020
2. Du W, de Vries E, van Kuppeveld FJM, Matrosovich M, de Haan CAM
Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.
1. Nat Commun - published December 1, 2020
2. Jutzi D, Campagne S, Schmidt R, Reber S, Mechtersheimer J, Gypas F, Schweingruber C, Colombo M, von Schroetter C, Loughlin FE, Devoy A, Hedlund E, Zavolan M, Allain FH, Ruepp MD
Exploiting the diphtheria toxin internalization receptor enhances delivery of proteins to lysosomes for enzyme replacement therapy.
1. Sci Adv - published December 1, 2020
2. Sugiman-Marangos SN, Beilhartz GL, Zhao X, Zhou D, Hua R, Kim PK, Rini JM, Minassian BA, Melnyk RA
Structural Characterization of Two CO Molecules Bound to the Nitrogenase Active Site.
1. Angew Chem Int Ed Engl - published December 1, 2020
2. Buscagan TM, Perez KA, Maggiolo AO, Rees DC, Spatzal T
Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes.
1. NPJ Vaccines - published December 1, 2020
2. Verardi R, Lindesmith LC, Tsybovsky Y, Gorman J, Chuang GY, Edwards CE, Brewer-Jensen PD, Mallory ML, Ou L, Schön A, Shi W, Tully ES, Georgiou G, Baric RS, Kwong PD
Allosteric cooperation in a de novo-designed two-domain protein.
1. Proc Natl Acad Sci U S A - published December 1, 2020
2. Pirro F, Schmidt N, Lincoff J, Widel ZX, Polizzi NF, Liu L, Therien MJ, Grabe M, Chino M, Lombardi A, DeGrado WF
ClonoMatch: a tool for identifying homologous immunoglobulin and T cell receptor sequences in large databases.
1. Bioinformatics - published December 1, 2020
2. Jones T, Day SB, Myers L, Crowe JE, Soto C
Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2.
1. ACS Med Chem Lett - published December 1, 2020
2. Ghahremanpour MM, Tirado-Rives J, Deshmukh M, Ippolito JA, Zhang CH, Cabeza de Vaca I, Liosi ME, Anderson KS, Jorgensen WL
Non-invasive testing for liver pathology in alpha-1 antitrypsin deficiency.
1. BMJ Open Respir Res - published December 1, 2020
2. Abbas SH, Pickett E, Lomas DA, Thorburn D, Gooptu B, Hurst JR, Marshall A
An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex.
1. Nucleic Acids Res - published December 1, 2020
2. Hammel M, Rashid I, Sverzhinsky A, Pourfarjam Y, Tsai MS, Ellenberger T, Pascal JM, Kim IK, Tainer JA, Tomkinson AE
Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis.
1. PLoS Biol - published December 1, 2020
2. Xu C, Fischer DK, Rankovic S, Li W, Dick RA, Runge B, Zadorozhnyi R, Ahn J, Aiken C, Polenova T, Engelman AN, Ambrose Z, Rousso I, Perilla JR
Scan and Unlock: A programmable DNA molecular automaton for cell-selective activation of ligand-based signaling.
1. Angew Chem Int Ed Engl - published December 1, 2020
2. Zhang J, Qiu Z, Fan J, He F, Kang W, Yang S, Wang HH, Huang J, Nie Z
l-Threonine Transaldolase Activity Is Enabled by a Persistent Catalytic Intermediate.
1. ACS Chem Biol - published December 1, 2020
2. Kumar P, Meza A, Ellis JM, Carlson GA, Bingman CA, Buller AR
Virus-Like Particle Based Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide.
1. Vaccines (Basel) - published December 1, 2020
2. Mogus AT, Liu L, Jia M, Ajayi DT, Xu K, Kong R, Huang J, Yu J, Kwong PD, Mascola JR, Ho DD, Tsuji M, Chackerian B
CryoEM map of Pseudomonas aeruginosa PilQ enables structural characterization of TsaP.
1. Structure - published December 1, 2020
2. McCallum M, Tammam S, Rubinstein JL, Burrows LL, Howell PL
Mechanism of efficient double-strand break repair by a long non-coding RNA.
1. Nucleic Acids Res - published December 1, 2020
2. Thapar R, Wang JL, Hammel M, Ye R, Liang K, Sun C, Hnizda A, Liang S, Maw SS, Lee L, Villarreal H, Forrester I, Fang S, Tsai MS, Blundell TL, Davis AJ, Lin C, Lees-Miller SP, Strick TR, Tainer JA
Elongin A associates with actively transcribed genes and modulates enhancer RNA levels with limited impact on transcription elongation rate in vivo.
1. J Biol Chem - published December 1, 2020
2. Ardehali MB, Damle M, Perea-Resa C, Blower MD, Kingston RE
Analytical Ultracentrifugation (AUC): An Overview of the Application of Fluorescence and Absorbance AUC to the Study of Biological Macromolecules.
1. Curr Protoc Mol Biol - published December 1, 2020
2. Edwards GB, Muthurajan UM, Bowerman S, Luger K
Termini restraining of small membrane proteins enables structure determination at near-atomic resolution.
1. Sci Adv - published December 1, 2020
2. Liu S, Li S, Yang Y, Li W
Structural basis of client specificity in mitochondrial membrane-protein chaperones.
1. Sci Adv - published December 1, 2020
2. Sučec I, Wang Y, Dakhlaoui O, Weinhäupl K, Jores T, Costa D, Hessel A, Brennich M, Rapaport D, Lindorff-Larsen K, Bersch B, Schanda P
Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
1. Mol Cell - published December 1, 2020
2. Kato K, Ahmad S, Zhu Z, Young JM, Mu X, Park S, Malik HS, Hur S
The protein-protein interactions required for assembly of the Tn3 resolution synapse.
1. Mol Microbiol - published December 1, 2020
2. Rowland SJ, Boocock MR, Burke ME, Rice PA, Stark WM
COVID-19-neutralizing antibodies predict disease severity and survival.
1. Cell - published December 1, 2020
2. Garcia-Beltran WF, Lam EC, Astudillo MG, Yang D, Miller TE, Feldman J, Hauser BM, Caradonna TM, Clayton KL, Nitido AD, Murali MR, Alter G, Charles RC, Dighe A, Branda JA, Lennerz JK, Lingwood D, Schmidt AG, Iafrate AJ, Balazs AB
Stoichiometry of Nucleotide Binding to Proteasome AAA+ ATPase Hexamer Established by Native Mass Spectrometry.
1. Mol Cell Proteomics - published December 1, 2020
2. Yu Y, Liu H, Yu Z, Witkowska HE, Cheng Y
Shared requirements for key residues in the antibiotic resistance enzymes ErmC and ErmE suggest a common mode of RNA recognition.
1. J Biol Chem - published December 1, 2020
2. Rowe SJ, Mecaskey RJ, Nasef M, Talton RC, Sharkey RE, Halliday JC, Dunkle JA
A structural and kinetic survey of GH5_4 endoglucanases reveals determinants of broad substrate specificity and opportunities for biomass hydrolysis.
1. J Biol Chem - published December 1, 2020
2. Glasgow EM, Kemna EI, Bingman CA, Ing N, Deng K, Bianchetti CM, Takasuka TE, Northen TR, Fox BG
Machine learning a model for RNA structure prediction.
1. NAR Genom Bioinform - published December 1, 2020
2. Calonaci N, Jones A, Cuturello F, Sattler M, Bussi G