Member Publications

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146 Member Publications for August 2020

Investigating Cell Signaling with Gene Expression Datasets.
1. CourseSource - published August 29, 2020
2. Wachira J, Hughes-Darden C, Nkwanta A
Intrinsic disorder in the nickel-dependent urease network.
1. Prog Mol Biol Transl Sci - published August 24, 2020
2. Zambelli B, Mazzei L, Ciurli S
Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence.
1. Cell Discov - published August 21, 2020
2. Chi X, Jin X, Chen Y, Lu X, Tu X, Li X, Zhang Y, Lei J, Huang J, Huang Z, Zhou Q, Pan X
Extracellular Vesicles and Their Roles in Cancer Progression.
1. Methods Mol Biol - published August 20, 2020
2. Chang WH, Cerione RA, Antonyak MA
Heterologous expression of a glycosyl hydrolase and cellular reprogramming enable Zymomonas mobilis growth on cellobiose.
1. PLoS One - published August 16, 2020
2. Kurumbang NP, Vera JM, Hebert AS, Coon JJ, Landick R
Extended Experimental Inferential Structure Determination Method in Determining the Structural Ensembles of Disordered Protein States.
1. Commun Chem - published August 11, 2020
2. Lincoff J, Haghighatlari M, Krzeminski M, Teixeira JMC, Gomes GW, Gradinaru CC, Forman-Kay JD, Head-Gordon T
High-Throughput Screening of a Functional Human CXCL12-CXCR4 Signaling Axis in a Genetically Modified S. cerevisiae: Discovery of a Novel Up-Regulator of CXCR4 Activity.
1. Front Mol Biosci - published August 9, 2020
2. Murphy JW, Rajasekaran D, Merkel J, Skeens E, Keeler C, Hodsdon ME, Lisi GP, Lolis E
The Effects of Framework Mutations at the Variable Domain Interface on Antibody Affinity Maturation in an HIV-1 Broadly Neutralizing Antibody Lineage.
1. Front Immunol - published August 9, 2020
2. Zhou JO, Zaidi HA, Ton T, Fera D
1H, 13C, and 15N backbone chemical shift assignments of the nucleic acid-binding domain of SARS-CoV-2 non-structural protein 3e.
1. Biomol NMR Assign - published August 8, 2020
2. Korn SM, Dhamotharan K, Fürtig B, Hengesbach M, Löhr F, Qureshi NS, Richter C, Saxena K, Schwalbe H, Tants JN, Weigand JE, Wöhnert J, Schlundt A
Transient intracellular acidification regulates the core transcriptional heat shock response.
1. Elife - published August 7, 2020
2. Triandafillou CG, Katanski CD, Dinner AR, Drummond DA
Structural insights into the Ca2+-dependent gating of the human mitochondrial calcium uniporter.
1. Elife - published August 7, 2020
2. Wang Y, Han Y, She J, Nguyen NX, Mootha VK, Bai XC, Jiang Y
Nuclear Egress of Herpesviruses.
1. Curr Issues Mol Biol - published August 7, 2020
2. Draganova EB, Thorsen MK, Heldwein EE
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.
1. Elife - published August 7, 2020
2. Tsutsumi N, Mukherjee S, Waghray D, Janda CY, Jude KM, Miao Y, Burg JS, Aduri NG, Kossiakoff AA, Gati C, Garcia KC
Structure, function and assembly of the long, flexible tail of siphophages.
1. Curr Opin Virol - published August 7, 2020
2. Linares R, Arnaud CA, Degroux S, Schoehn G, Breyton C
Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site.
1. Cell Host Microbe - published August 7, 2020
2. Powell LA, Miller A, Fox JM, Kose N, Klose T, Kim AS, Bombardi R, Tennekoon RN, Dharshan de Silva A, Carnahan RH, Diamond MS, Rossmann MG, Kuhn RJ, Crowe JE Jr
Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases.
1. J Med Chem - published August 6, 2020
2. Ma B, Bohnert T, Otipoby KL, Tien E, Arefayene M, Bai J, Bajrami B, Bame E, Chan TR, Humora M, MacPhee JM, Marcotte D, Mehta D, Metrick CM, Moniz G, Polack E, Poreci U, Prefontaine A, Sheikh S, Schroeder P, Smirnakis K, Zhang L, Zheng F, Hopkins BT
A cross-reactive antibody protects against Ross River virus musculoskeletal disease despite rapid neutralization escape in mice.
1. PLoS Pathog - published August 6, 2020
2. Fox JM, Huang L, Tahan S, Powell LA, Crowe JE Jr, Wang D, Diamond MS
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2.
1. Proc Natl Acad Sci U S A - published August 6, 2020
2. Kang YL, Chou YY, Rothlauf PW, Liu Z, Soh TK, Cureton D, Case JB, Chen RE, Diamond MS, Whelan SPJ, Kirchhausen T
A molecular pore spans the double membrane of the coronavirus replication organelle.
1. Science - published August 6, 2020
2. Wolff G, Limpens RWAL, Zevenhoven-Dobbe JC, Laugks U, Zheng S, de Jong AWM, Koning RI, Agard DA, Grünewald K, Koster AJ, Snijder EJ, Bárcena M
Primary Role of the Nucleosome.
1. Mol Cell - published August 6, 2020
2. Kornberg RD, Lorch Y
Identification of Structurally Related Antibodies in Antibody Sequence Databases Using Rosetta-Derived Position-Specific Scoring.
1. Structure - published August 6, 2020
2. Finn JA, Dong J, Sevy AM, Parrish E, Gilchuk I, Nargi R, Scarlett-Jones M, Reichard W, Bombardi R, Voss TG, Meiler J, Crowe JE Jr
The Antibody Society's antibody validation webinar series.
1. MAbs - published August 5, 2020
2. Voskuil JLA, Bandrowski A, Begley CG, Bradbury ARM, Chalmers AD, Gomes AV, Hardcastle T, Lund-Johansen F, Plückthun A, Roncador G, Solache A, Taussig MJ, Trimmer JS, Williams C, Goodman SL
The Enzyme-Free Release of Nucleotides from Phosphoramidates Depends Strongly on the Amino Acid.
1. Angew Chem Int Ed Engl - published August 5, 2020
2. Richert C, Jovanovic D, Tremmel P, Pallan SP, Egli M
SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness.
1. Nature - published August 5, 2020
2. Corbett KS, Edwards DK, Leist SR, Abiona OM, Boyoglu-Barnum S, Gillespie RA, Himansu S, Schäfer A, Ziwawo CT, DiPiazza AT, Dinnon KH, Elbashir SM, Shaw CA, Woods A, Fritch EJ, Martinez DR, Bock KW, Minai M, Nagata BM, Hutchinson GB, Wu K, Henry C, Bahi K, Garcia-Dominguez D, Ma L, Renzi I, Kong WP, Schmidt SD, Wang L, Zhang Y, Phung E, Chang LA, Loomis RJ, Altaras NE, Narayanan E, Metkar M, Presnyak V, Liu C, Louder MK, Shi W, Leung K, Yang ES, West A, Gully KL, Stevens LJ, Wang N, Wrapp D, Doria-Rose NA, Stewart-Jones G, Bennett H, Alvarado GS, Nason MC, Ruckwardt TJ, McLellan JS, Denison MR, Chappell JD, Moore IN, Morabito KM, Mascola JR, Baric RS, Carfi A, Graham BS
interferENZY: A Web-Based Tool for Enzymatic Assay Validation and Standardized Kinetic Analysis.
1. J Mol Biol - published August 5, 2020
2. Pinto MF, Baici A, Pereira PJB, Macedo-Ribeiro S, Pastore A, Rocha F, Martins PM
Optimizing the anti-tumor efficacy of protein-drug conjugates by engineering the molecular size and half-life.
1. J Control Release - published August 5, 2020
2. Brandl F, Busslinger S, Zangemeister-Wittke U, Plückthun A
Anti-influenza H7 human antibody targets antigenic site in hemagglutinin head domain interface.
1. J Clin Invest - published August 4, 2020
2. Dong J, Gilchuk I, Li S, Irving R, Goff MT, Turner HL, Ward AB, Carnahan RH, Crowe JE Jr
Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1.
1. Elife - published August 4, 2020
2. Schrecker M, Korobenko J, Hite RK
Synthetic nanobodies as angiotensin receptor blockers.
1. Proc Natl Acad Sci U S A - published August 4, 2020
2. McMahon C, Staus DP, Wingler LM, Wang J, Skiba MA, Elgeti M, Hubbell WL, Rockman HA, Kruse AC, Lefkowitz RJ
Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature.
1. Cell Rep - published August 4, 2020
2. Cheng C, Duan H, Xu K, Chuang GY, Corrigan AR, Geng H, O'Dell S, Ou L, Chambers M, Changela A, Chen X, Foulds KE, Sarfo EK, Jafari AJ, Hill KR, Kong R, Liu K, Todd JP, Tsybovsky Y, Verardi R, Wang S, Wang Y, Wu W, Zhou T, VRC Production Program., Arnold FJ, Doria-Rose NA, Koup RA, McDermott AB, Scorpio DG, Worobey M, Shapiro L, Mascola JR, Kwong PD
Chemical Biology Toolkit for DCLK1 Reveals Connection to RNA Processing.
1. Cell Chem Biol - published August 4, 2020
2. Liu Y, Ferguson FM, Li L, Kuljanin M, Mills CE, Subramanian K, Harshbarger W, Gondi S, Wang J, Sorger PK, Mancias JD, Gray NS, Westover KD
Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.
1. bioRxiv - published August 4, 2020
2. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Lim SA, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Zhou XX, Hobman TC, Kortemme T, Wells JA
CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis.
1. Immunity - published August 4, 2020
2. Morrissey MA, Kern N, Vale RD
The Structural Determinants of PH Domain-Mediated Regulation of Akt Revealed by Segmental Labeling.
1. Elife - published August 3, 2020
2. Chu N, Viennet T, Bae H, Salguero A, Boeszoermenyi A, Arthanari H, Cole PA
Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step.
1. PLoS Pathog - published August 3, 2020
2. Ye X, Su H, Wrapp D, Freed DC, Li F, Yuan Z, Tang A, Li L, Ku Z, Xiong W, Jaijyan D, Zhu H, Wang D, McLellan JS, Zhang N, Fu TM, An Z
A proof of concept for biomarker-guided targeted therapy against ovarian cancer based on patient-derived tumor xenografts.
1. Cancer Res - published August 3, 2020
2. Palmer AC, Plana D, Gao H, Korn JM, Yang G, Green J, Zhang X, Velazquez R, McLaughlin ME, Ruddy DA, Kowal C, Goldovitz J, Bullock C, Rivera S, Rakiec DP, Elliott G, Fordjour P, Meyer R, Loo A, Kurth E, Engelman JA, Bitter H, Sellers WR, Williams JA, Sorger PK
Integrated pipeline for the accelerated discovery of antiviral antibody therapeutics.
1. Nat Biomed Eng - published August 3, 2020
2. Gilchuk P, Bombardi RG, Erasmus JH, Tan Q, Nargi R, Soto C, Abbink P, Suscovich TJ, Durnell LA, Khandhar A, Archer J, Liang J, Fouch ME, Davidson E, Doranz BJ, Jones T, Larson E, Ertel S, Granger B, Fuerte-Stone J, Roy V, Broge T, Linnekin TC, Linde CH, Gorman MJ, Nkolola J, Alter G, Reed SG, Barouch DH, Diamond MS, Crowe JE Jr, Van Hoeven N, Thackray LB, Carnahan RH
Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
1. Nat Struct Mol Biol - published August 3, 2020
2. Mahalingan KK, Keith Keenen E, Strickland M, Li Y, Liu Y, Ball HL, Tanner ME, Tjandra N, Roll-Mecak A
The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma.
1. Nat Struct Mol Biol - published August 3, 2020
2. McBride MJ, Mashtalir N, Winter EB, Dao HT, Filipovski M, D'Avino AR, Seo HS, Umbreit NT, St Pierre R, Valencia AM, Qian K, Zullow HJ, Jaffe JD, Dhe-Paganon S, Muir TW, Kadoch C
Domain cross-talk in regulation of histone modifications: Molecular mechanisms and targeting opportunities.
1. Curr Opin Chem Biol - published August 3, 2020
2. Longbotham JE, Zhang MY, Fujimori DG
Structural annotation of the conserved carbohydrate esterase vb_24B_21 from Shiga toxin-encoding bacteriophage Φ24B.
1. J Struct Biol - published August 3, 2020
2. Franke B, Veses-Garcia M, Diederichs K, Allison H, Rigden DJ, Mayans O
Assessment of the Fragment Docking Program SEED.
1. J Chem Inf Model - published August 3, 2020
2. Goossens K, Wroblowski B, Langini C, van Vlijmen H, Caflisch A, De Winter H
Distinct disease features in chimpanzees infected with a precore HBV mutant associated with acute liver failure in humans.
1. PLoS Pathog - published August 3, 2020
2. Chen Z, Engle RE, Shen CH, Zhao H, Schuck PW, Danoff EJ, Nguyen H, Nishimura N, Bock KW, Moore IN, Kwong PD, Purcell RH, Govindarajan S, Farci P
Exploring cellular biochemistry with nanobodies.
1. J Biol Chem - published August 3, 2020
2. Cheloha RW, Harmand TJ, Wijne C, Schwartz TU, Ploegh HL
Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.
1. Nat Struct Mol Biol - published August 3, 2020
2. Fromm SA, Lawrence RE, Hurley JH
A SARS-CoV-2 vaccine candidate would likely match all currently circulating variants.
1. Proc Natl Acad Sci U S A - published August 3, 2020
2. Dearlove B, Lewitus E, Bai H, Li Y, Reeves DB, Joyce MG, Scott PT, Amare MF, Vasan S, Michael NL, Modjarrad K, Rolland M
Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.
1. Am J Hum Genet - published August 3, 2020
2. Connaughton DM, Dai R, Owen DJ, Marquez J, Mann N, Graham-Paquin AL, Nakayama M, Coyaud E, Laurent EMN, St-Germain JR, Blok LS, Vino A, Klämbt V, Deutsch K, Wu CW, Kolvenbach CM, Kause F, Ottlewski I, Schneider R, Kitzler TM, Majmundar AJ, Buerger F, Onuchic-Whitford AC, Youying M, Kolb A, Salmanullah D, Chen E, van der Ven AT, Rao J, Ityel H, Seltzsam S, Rieke JM, Chen J, Vivante A, Hwang DY, Kohl S, Dworschak GC, Hermle T, Alders M, Bartolomaeus T, Bauer SB, Baum MA, Brilstra EH, Challman TD, Zyskind J, Costin CE, Dipple KM, Duijkers FA, Ferguson M, Fitzpatrick DR, Fick R, Glass IA, Hulick PJ, Kline AD, Krey I, Kumar S, Lu W, Marco EJ, Wentzensen IM, Mefford HC, Platzer K, Povolotskaya IS, Savatt JM, Shcherbakova NV, Senguttuvan P, Squire AE, Stein DR, Thiffault I, Voinova VY, Somers MJG, Ferguson MA, Traum AZ, Daouk GH, Daga A, Rodig NM, Terhal PA, van Binsbergen E, Eid LA, Tasic V, Rasouly HM, Lim TY, Ahram DF, Gharavi AG, Reutter HM, Rehm HL, MacArthur DG, Lek M, Laricchia KM, Lifton RP, Xu H, Mane SM, Sanna-Cherchi S, Sharrocks AD, Raught B, Fisher SE, Bouchard M, Khokha MK, Shril S, Hildebrandt F
A Platform Incorporating Trimeric Antigens into Self-Assembling Nanoparticles Reveals SARS-CoV-2-Spike Nanoparticles to Elicit Substantially Higher Neutralizing Responses than Spike Alone.
1. bioRxiv - published August 2, 2020
2. Zhang B, Chao CW, Tsybovsky Y, Abiona OM, Hutchinson GB, Moliva JI, Olia AS, Pegu A, Phung E, Stewart-Jones G, Verardi R, Wang L, Wang S, Werner A, Yang ES, Yap C, Zhou T, Mascola JR, Sullivan NJ, Graham BS, Corbett KS, Kwong PD
A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions.
1. Cell - published August 2, 2020
2. Wojtowicz WM, Vielmetter J, Fernandes RA, Siepe DH, Eastman CL, Chisholm GB, Cox S, Klock H, Anderson PW, Rue SM, Miller JJ, Glaser SM, Bragstad ML, Vance J, Lam AW, Lesley SA, Zinn K, Garcia KC
Chemical Tools in Biological Discovery.
1. Cell Chem Biol - published August 2, 2020
2. Dey M, Weerapana E
An ER translocon for multi-pass membrane protein biogenesis.
1. Elife - published August 2, 2020
2. McGilvray PT, Anghel SA, Sundaram A, Zhong F, Trnka MJ, Fuller JR, Hu H, Burlingame AL, Keenan RJ
Tandem sialoglycan-binding modules in a Streptococcus sanguinis serine-rich repeat adhesin create target dependent avidity effects.
1. J Biol Chem - published August 2, 2020
2. Stubbs HE, Bensing BA, Yamakawa I, Sharma P, Yu H, Chen X, Sullam PM, Iverson TM
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction.
1. Nat Commun - published August 2, 2020
2. Ejemel M, Li Q, Hou S, Schiller ZA, Tree JA, Wallace A, Amcheslavsky A, Kurt Yilmaz N, Buttigieg KR, Elmore MJ, Godwin K, Coombes N, Toomey JR, Schneider R, Ramchetty AS, Close BJ, Chen DY, Conway HL, Saeed M, Ganesa C, Carroll MW, Cavacini LA, Klempner MS, Schiffer CA, Wang Y
Structure and Reconstitution of a MCU-EMRE Mitochondrial Ca²⁺ Uniporter Complex.
1. J Mol Biol - published August 2, 2020
2. Wang C, Baradaran R, Long SB
3D structure of three jumbo phage heads.
1. J Gen Virol - published August 2, 2020
2. Neumann E, Kawasaki T, Effantin G, Estrozi LF, Chatchawankanphanich O, Yamada T, Schoehn G
An Opaque Cell-Specific Expression Program of Secreted Proteases and Transporters Allows Cell-Type Cooperation in Candida albicans.
1. Genetics - published August 2, 2020
2. Lohse MB, Brenes LR, Ziv N, Winter MB, Craik CS, Johnson AD
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function.
1. Nat Immunol - published August 2, 2020
2. Winkler ES, Bailey AL, Kafai NM, Nair S, McCune BT, Yu J, Fox JM, Chen RE, Earnest JT, Keeler SP, Ritter JH, Kang LI, Dort S, Robichaud A, Head R, Holtzman MJ, Diamond MS
Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor.
1. Cell Host Microbe - published August 2, 2020
2. Zhao P, Praissman JL, Grant OC, Cai Y, Xiao T, Rosenbalm KE, Aoki K, Kellman BP, Bridger R, Barouch DH, Brindley MA, Lewis NE, Tiemeyer M, Chen B, Woods RJ, Wells L
Atomic structure of a mitochondrial complex I intermediate from vascular plants.
1. Elife - published August 2, 2020
2. Maldonado M, Padavannil A, Zhou L, Guo F, Letts JA
Cryo-EM analysis of PIP₂ regulation in mammalian GIRK channels.
1. Elife - published August 2, 2020
2. Niu Y, Tao X, Touhara KK, MacKinnon R
Real-Time In-Cell NMR Reveals the Intracellular Modulation of GTP-Bound Levels of RAS.
1. Cell Rep - published August 2, 2020
2. Zhao Q, Fujimiya R, Kubo S, Marshall CB, Ikura M, Shimada I, Nishida N
An allosteric site on MKP5 reveals a strategy for small-molecule inhibition.
1. Sci Signal - published August 2, 2020
2. Gannam ZTK, Min K, Shillingford SR, Zhang L, Herrington J, Abriola L, Gareiss PC, Pantouris G, Tzouvelekis A, Kaminski N, Zhang X, Yu J, Jamali H, Ellman JA, Lolis E, Anderson KS, Bennett AM
Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6.
1. Nat Commun - published August 2, 2020
2. Schmidt JM, Bleichert F
4-Hydroxyacetophenone modulates the actomyosin cytoskeleton to reduce metastasis.
1. Proc Natl Acad Sci U S A - published August 2, 2020
2. Bryan DS, Stack M, Krysztofiak K, Cichoń U, Thomas DG, Surcel A, Schiffhauer ES, Beckett MA, Khodarev NN, Xue L, Poli EC, Pearson AT, Posner MC, Robinson DN, Rock RS, Weichselbaum RR
Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD.
1. Nature - published August 2, 2020
2. Su MY, Fromm SA, Zoncu R, Hurley JH
A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress.
1. Elife - published August 2, 2020
2. Stephani M, Picchianti L, Gajic A, Beveridge R, Skarwan E, Sanchez de Medina Hernandez V, Mohseni A, Clavel M, Zeng Y, Naumann C, Matuszkiewicz M, Turco E, Loefke C, Li B, Dürnberger G, Schutzbier M, Chen HT, Abdrakhmanov A, Savova A, Chia KS, Djamei A, Schaffner I, Abel S, Jiang L, Mechtler K, Ikeda F, Martens S, Clausen T, Dagdas Y
Heterosis-associated genes confer high yield in super hybrid rice.
1. Theor Appl Genet - published August 2, 2020
2. Lin T, Zhou C, Chen G, Yu J, Wu W, Ge Y, Liu X, Li J, Jiang X, Tang W, Tian Y, Zhao Z, Zhu C, Wang C, Wan J
EBV gH/gL and KSHV gH/gL bind to different sites on EphA2 to trigger fusion.
1. J Virol - published August 2, 2020
2. Chen J, Schaller S, Jardetzky TS, Longnecker R
Thrombosis in COVID-19.
1. Am J Hematol - published August 2, 2020
2. Hanff TC, Mohareb AM, Giri J, Cohen JB, Chirinos JA
Clinical sensitivity and interpretation of PCR and serological COVID-19 diagnostics for patients presenting to the hospital.
1. FASEB J - published August 2, 2020
2. Miller TE, Garcia Beltran WF, Bard AZ, Gogakos T, Anahtar MN, Astudillo MG, Yang D, Thierauf J, Fisch AS, Mahowald GK, Fitzpatrick MJ, Nardi V, Feldman J, Hauser BM, Caradonna TM, Marble HD, Ritterhouse LL, Turbett SE, Batten J, Georgantas NZ, Alter G, Schmidt AG, Harris JB, Gelfand JA, Poznansky MC, Bernstein BE, Louis DN, Dighe A, Charles RC, Ryan ET, Branda JA, Pierce VM, Murali MR, Iafrate AJ, Rosenberg ES, Lennerz JK
Diverse enzymatic activities mediate antiviral immunity in prokaryotes.
1. Science - published August 2, 2020
2. Gao L, Altae-Tran H, Böhning F, Makarova KS, Segel M, Schmid-Burgk JL, Koob J, Wolf YI, Koonin EV, Zhang F
The cryoelectron microscopy structure of the human CDK-activating kinase.
1. Proc Natl Acad Sci U S A - published August 2, 2020
2. Greber BJ, Perez-Bertoldi JM, Lim K, Iavarone AT, Toso DB, Nogales E
Expanding the space of protein geometries by computational design of de novo fold families.
1. Science - published August 2, 2020
2. Pan X, Thompson MC, Zhang Y, Liu L, Fraser JS, Kelly MJS, Kortemme T
Zymogen and activated protein C have similar structural architecture.
1. J Biol Chem - published August 2, 2020
2. Stojanovski BM, Pelc LA, Zuo X, Di Cera E
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance.
1. Nat Biotechnol - published August 2, 2020
2. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD 2nd, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk RP, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A
Diversity in the intrinsic apoptosis pathway of nematodes.
1. Commun Biol - published August 2, 2020
2. Young ND, Harris TJ, Evangelista M, Tran S, Wouters MA, Soares da Costa TP, Kershaw NJ, Gasser RB, Smith BJ, Lee EF, Fairlie WD
Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection.
1. Nat Commun - published August 2, 2020
2. Giansanti P, Strating JRPM, Defourny KAY, Cesonyte I, Bottino AMS, Post H, Viktorova EG, Ho VQT, Langereis MA, Belov GA, Nolte-'t Hoen ENM, Heck AJR, van Kuppeveld FJM
State-dependent sequential allostery exhibited by chaperonin TRiC/CCT revealed by network analysis of Cryo-EM maps.
1. Prog Biophys Mol Biol - published August 2, 2020
2. Zhang Y, Krieger J, Mikulska-Ruminska K, Kaynak B, Sorzano COS, Carazo JM, Xing J, Bahar I
The Corrosion Features of Q235B Steel under Immersion Test and Electrochemical Measurements in Desulfurization Solution.
1. Materials (Basel) - published August 2, 2020
2. Gong P, Zhang G, Chen J
Proprotein convertase 7 (PCSK7) reduces apoA-V levels.
1. FEBS J - published August 1, 2020
2. Ashraf Y, Duval S, Sachan V, Essalmani R, Susan-Resiga D, Roubtsova A, Hamelin J, Gerhardy S, Kirchhofer D, Tagliabracci VS, Prat A, Kiss RS, Seidah NG
Fenretinide induces a new form of dynamin-dependent cell death in pediatric sarcoma.
1. Cell Death Differ - published August 1, 2020
2. Brack E, Wachtel M, Wolf A, Kaech A, Ziegler U, Schäfer BW
The Helicobacter pylori Cag Type IV Secretion System.
1. Trends Microbiol - published August 1, 2020
2. Cover TL, Lacy DB, Ohi MD
Building an international consortium for tracking coronavirus health status.
1. Nat Med - published August 1, 2020
2. Segal E, Zhang F, Lin X, King G, Shalem O, Shilo S, Allen WE, Alquaddoomi F, Altae-Tran H, Anders S, Balicer R, Bauman T, Bonilla X, Booman G, Chan AT, Cohen O, Coletti S, Davidson N, Dor Y, Drew DA, Elemento O, Evans G, Ewels P, Gale J, Gavrieli A, Geiger B, Grad YH, Greene CS, Hajirasouliha I, Jerala R, Kahles A, Kallioniemi O, Keshet A, Kocarev L, Landua G, Meir T, Muller A, Nguyen LH, Oresic M, Ovchinnikova S, Peterson H, Prodanova J, Rajagopal J, Rätsch G, Rossman H, Rung J, Sboner A, Sigaras A, Spector T, Steinherz R, Stevens I, Vilo J, Wilmes P
An integrated biophysical approach to discovering mechanisms of NDM-1 inhibition for several thiol-containing drugs.
1. J Biol Inorg Chem - published August 1, 2020
2. Fullington S, Cheng Z, Thomas C, Miller C, Yang K, Ju LC, Bergstrom A, Shurina BA, Bretz SL, Page RC, Tierney DL, Crowder MW
Publisher Correction: Building an international consortium for tracking coronavirus health status.
1. Nat Med - published August 1, 2020
2. Segal E, Zhang F, Lin X, King G, Shalem O, Shilo S, Allen WE, Alquaddoomi F, Altae-Tran H, Anders S, Balicer R, Bauman T, Bonilla X, Booman G, Chan AT, Cohen O, Coletti S, Davidson N, Dor Y, Drew DA, Elemento O, Evans G, Ewels P, Gale J, Gavrieli A, Geiger B, Grad YH, Greene CS, Hajirasouliha I, Jerala R, Kahles A, Kallioniemi O, Keshet A, Kocarev L, Landua G, Meir T, Muller A, Nguyen LH, Oresic M, Ovchinnikova S, Peterson H, Prodanova J, Rajagopal J, Rätsch G, Rossman H, Rung J, Sboner A, Sigaras A, Spector T, Steinherz R, Stevens I, Vilo J, Wilmes P
Targeting the TS dimer interface in bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa: Virtual screening identifies novel TS allosteric inhibitors.
1. Bioorg Med Chem Lett - published August 1, 2020
2. Ruiz VG, Czyzyk DJ, Kumar VP, Jorgensen WL, Anderson KS
Conformational Motions and Water Networks at the α/β Interface in E. coli Ribonucleotide Reductase.
1. J Am Chem Soc - published August 1, 2020
2. Reinhardt CR, Li P, Kang G, Stubbe J, Drennan CL, Hammes-Schiffer S
Discovery of phenanthridine analogues as novel chemical probes disrupting the binding of DNA to ΔFosB homodimers and ΔFosB/JunD heterodimers.
1. Bioorg Med Chem Lett - published August 1, 2020
2. Li Y, Liu Z, Aglyamova G, Chen J, Chen H, Bhandari M, White MA, Rudenko G, Zhou J
Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere.
1. J Med Chem - published August 1, 2020
2. Rusere LN, Lockbaum GJ, Henes M, Lee SK, Spielvogel E, Rao DN, Kosovrasti K, Nalivaika EA, Swanstrom R, Kurt Yilmaz N, Schiffer CA, Ali A
Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods.
1. J Med Chem - published August 1, 2020
2. Sarkar D, Olejniczak ET, Phan J, Coker JA, Sai J, Arnold A, Beesetty Y, Waterson AG, Fesik SW
Model-based analysis of chromatin interactions from dCas9-Based CAPTURE-3C-seq.
1. PLoS One - published August 1, 2020
2. Chen Y, Wang Y, Liu X, Xu J, Zhang MQ
Attaining atomic resolution from in situ data collection at room temperature using counter-diffusion-based low-cost microchips.
1. Acta Crystallogr D Struct Biol - published August 1, 2020
2. Gavira JA, Rodriguez-Ruiz I, Martinez-Rodriguez S, Basu S, Teychené S, McCarthy AA, Mueller-Dieckman C
Fragment-based determination of a proteinase K structure from MicroED data using ARCIMBOLDO_SHREDDER.
1. Acta Crystallogr D Struct Biol - published August 1, 2020
2. Richards LS, Millán C, Miao J, Martynowycz MW, Sawaya MR, Gonen T, Borges RJ, Usón I, Rodriguez JA
Characterization of missense mutations in the signal peptide and propeptide of FIX in hemophilia B by a cell-based assay.
1. Blood Adv - published August 1, 2020
2. Gao W, Xu Y, Liu H, Gao M, Cao Q, Wang Y, Cui L, Huang R, Shen Y, Li S, Yang H, Chen Y, Li C, Yu H, Li W, Shen G
Antagonistic anti-LILRB1 monoclonal antibody regulates antitumor functions of natural killer cells.
1. J Immunother Cancer - published August 1, 2020
2. Chen H, Chen Y, Deng M, John S, Gui X, Kansagra A, Chen W, Kim J, Lewis C, Wu G, Xie J, Zhang L, Huang R, Liu X, Arase H, Huang Y, Yu H, Luo W, Xia N, Zhang N, An Z, Zhang CC
The structural basis of Bcl-2 mediated cell death regulation in Hydra.
1. Biochem J - published August 1, 2020
2. Banjara S, D Sa J, Hinds MG, Kvansakul M
Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo.
1. Elife - published August 1, 2020
2. Fernandes RA, Li C, Wang G, Yang X, Savvides CS, Glassman CR, Dong S, Luxenberg E, Sibener LV, Birnbaum ME, Benoist C, Mathis D, Garcia KC
Primate lentiviruses require Inositol hexakisphosphate (IP6) or inositol pentakisphosphate (IP5) for the production of viral particles.
1. PLoS Pathog - published August 1, 2020
2. Ricana CL, Lyddon TD, Dick RA, Johnson MC
The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment.
1. Elife - published August 1, 2020
2. Shi X, Chang C, Yokom AL, Jensen LE, Hurley JH
Time-resolved cryo-EM using Spotiton.
1. Nat Methods - published August 1, 2020
2. Dandey VP, Budell WC, Wei H, Bobe D, Maruthi K, Kopylov M, Eng ET, Kahn PA, Hinshaw JE, Kundu N, Nimigean CM, Fan C, Sukomon N, Darst SA, Saecker RM, Chen J, Malone B, Potter CS, Carragher B
Hydroxamic Acids Immobilized on Resins (HAIRs): A Toolbox for the Synthesis of Dual-Targeting HDAC Inhibitors and HDAC Degraders (PROTACs).
1. Angew Chem Int Ed Engl - published August 1, 2020
2. Sinatra L, Bandolik JJ, Roatsch M, Sönnichsen M, Schoeder CT, Hamacher A, Schoeler A, Borkhardt A, Meiler J, Bhatia S, Kassack MU, Hansen FK
Functional characterization of a PROTAC directed against BRAF mutant V600E.
1. Nat Chem Biol - published August 1, 2020
2. Posternak G, Tang X, Maisonneuve P, Jin T, Lavoie H, Daou S, Orlicky S, Goullet de Rugy T, Caldwell L, Chan K, Aman A, Prakesch M, Poda G, Mader P, Wong C, Maier S, Kitaygorodsky J, Larsen B, Colwill K, Yin Z, Ceccarelli DF, Batey RA, Taipale M, Kurinov I, Uehling D, Wrana J, Durocher D, Gingras AC, Al-Awar R, Therrien M, Sicheri F
Structural basis of salicylic acid perception by Arabidopsis NPR proteins.
1. Nature - published August 1, 2020
2. Wang W, Withers J, Li H, Zwack PJ, Rusnac DV, Shi H, Liu L, Yan S, Hinds TR, Guttman M, Dong X, Zheng N
Revealing the mechanism of repressor inactivation during switching of a temperate bacteriophage.
1. Proc Natl Acad Sci U S A - published August 1, 2020
2. Rasmussen KK, Palencia A, Varming AK, El-Wali H, Boeri Erba E, Blackledge M, Hammer K, Herrmann T, Kilstrup M, Lo Leggio L, Jensen MR
Dismantling and Rebuilding the Trisulfide Cofactor Demonstrates Its Essential Role in Human Sulfide Quinone Oxidoreductase.
1. J Am Chem Soc - published August 1, 2020
2. Landry AP, Moon S, Bonanata J, Cho US, Coitiño EL, Banerjee R
Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding.
1. ACS Chem Biol - published August 1, 2020
2. Newberry RW, Arhar T, Costello J, Hartoularos GC, Maxwell AM, Naing ZZC, Pittman M, Reddy NR, Schwarz DMC, Wassarman DR, Wu TS, Barrero D, Caggiano C, Catching A, Cavazos TB, Estes LS, Faust B, Fink EA, Goldman MA, Gomez YK, Gordon MG, Gunsalus LM, Hoppe N, Jaime-Garza M, Johnson MC, Jones MG, Kung AF, Lopez KE, Lumpe J, Martyn C, McCarthy EE, Miller-Vedam LE, Navarro EJ, Palar A, Pellegrino J, Saylor W, Stephens CA, Strickland J, Torosyan H, Wankowicz SA, Wong DR, Wong G, Redding S, Chow ED, DeGrado WF, Kampmann M
Correction to "Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one Scaffold".
1. J Med Chem - published August 1, 2020
2. Ferguson FM, Liu Y, Harshbarger W, Huang L, Wang J, Deng X, Capuzzi SJ, Muratov EN, Tropsha A, Muthuswamy S, Westover KD, Gray NS
Visualizing Nudivirus Assembly and Egress.
1. mBio - published August 1, 2020
2. Velamoor S, Mitchell A, Humbel BM, Kim W, Pushparajan C, Visnovsky G, Burga LN, Bostina M
Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction.
1. J Am Chem Soc - published August 1, 2020
2. Cogan DP, Li X, Sevillano N, Mathews II, Matsui T, Craik CS, Khosla C
Author Correction: Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
1. Nat Struct Mol Biol - published August 1, 2020
2. Mahalingan KK, Keith Keenan E, Strickland M, Li Y, Liu Y, Ball HL, Tanner ME, Tjandra N, Roll-Mecak A
Reengineering anthrax toxin protective antigen for improved receptor-specific protein delivery.
1. BMC Biol - published August 1, 2020
2. Becker L, Verdurmen WPR, Plückthun A
Structure-guided approaches to targeting stress responses in human fungal pathogens.
1. J Biol Chem - published August 1, 2020
2. LeBlanc EV, Polvi EJ, Veri AO, Privé GG, Cowen LE
The High-Resolution Structure of a UDP-l-Rhamnose Synthase from Acanthamoeba polyphaga Mimivirus.
1. Protein Sci - published August 1, 2020
2. Bockhaus NJ, Ferek JD, Thoden JB, Holden HM
Parallel Discovery Strategies Provide a Basis for Riboswitch Ligand Design.
1. Cell Chem Biol - published August 1, 2020
2. Tran B, Pichling P, Tenney L, Connelly CM, Moon MH, Ferré-D'Amaré AR, Schneekloth JS Jr, Jones CP
NMR in integrated biophysical drug discovery for RAS: past, present, and future.
1. J Biomol NMR - published August 1, 2020
2. Marshall CB, KleinJan F, Gebregiworgis T, Lee KY, Fang Z, Eves BJ, Liu NF, Gasmi-Seabrook GMC, Enomoto M, Ikura M
Phenotypic Profiling in Subjects Heterozygous for 1 of 2 Rare Variants in the Hypophosphatasia Gene (ALPL).
1. J Endocr Soc - published August 1, 2020
2. Tilden DR, Sheehan JH, Newman JH, Meiler J, Capra JA, Ramirez A, Simmons J, Dahir K
¹H, ¹³C, and ¹⁵N backbone chemical shift assignments of the apo and the ADP-ribose bound forms of the macrodomain of SARS-CoV-2 non-structural protein 3b.
1. Biomol NMR Assign - published August 1, 2020
2. Cantini F, Banci L, Altincekic N, Bains JK, Dhamotharan K, Fuks C, Fürtig B, Gande SL, Hargittay B, Hengesbach M, Hutchison MT, Korn SM, Kubatova N, Kutz F, Linhard V, Löhr F, Meiser N, Pyper DJ, Qureshi NS, Richter C, Saxena K, Schlundt A, Schwalbe H, Sreeramulu S, Tants JN, Wacker A, Weigand JE, Wöhnert J, Tsika AC, Fourkiotis NK, Spyroulias GA
The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures.
1. Elife - published August 1, 2020
2. Jaremko MJ, On KF, Thomas DR, Stillman B, Joshua-Tor L
Bacterial multi-solute transporters.
1. FEBS Lett - published August 1, 2020
2. Slotboom DJ, Ettema TW, Nijland M, Thangaratnarajah C
Structure and unique mechanical aspects of nuclear lamin filaments.
1. Curr Opin Struct Biol - published August 1, 2020
2. Tenga R, Medalia O
Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer.
1. Nat Chem Biol - published August 1, 2020
2. Cathcart AM, Bird GH, Wales TE, Herce HD, Harvey EP, Hauseman ZJ, Newman CE, Adhikary U, Prew MS, Oo T, Lee S, Engen JR, Walensky LD
Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments.
1. Cell Rep - published August 1, 2020
2. Rujas E, Insausti S, Leaman DP, Carravilla P, González-Resines S, Monceaux V, Sánchez-Eugenia R, García-Porras M, Iloro I, Zhang L, Elortza F, Julien JP, Saéz-Cirión A, Zwick MB, Eggeling C, Ojida A, Domene C, Caaveiro JMM, Nieva JL
Tissue-targeted R-spondin mimetics for liver regeneration.
1. Sci Rep - published August 1, 2020
2. Zhang Z, Broderick C, Nishimoto M, Yamaguchi T, Lee SJ, Zhang H, Chen H, Patel M, Ye J, Ponce A, Brady J, Baribault H, Li Y, Yeh WC
Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.
1. Nature - published August 1, 2020
2. Billesbølle CB, Azumaya CM, Kretsch RC, Powers AS, Gonen S, Schneider S, Arvedson T, Dror RO, Cheng Y, Manglik A
An Analysis of Isoclonal Antibody Formats Suggests a Role for Measuring PD-L1 with Low Molecular Weight PET Radiotracers.
1. Mol Imaging Biol - published August 1, 2020
2. Wei J, Wang YH, Lee CY, Truillet C, Oh DY, Xu Y, Ruggero D, Flavell RR, VanBrocklin HF, Seo Y, Craik CS, Fong L, Wang CI, Evans MJ
An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation.
1. bioRxiv - published August 1, 2020
2. Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium., Walter P, Manglik A
Structural basis for dimerization quality control.
1. Nature - published August 1, 2020
2. Mena EL, Jevtić P, Greber BJ, Gee CL, Lew BG, Akopian D, Nogales E, Kuriyan J, Rape M
Orsay CP-δ adopts a novel β-bracelet structural fold and incorporates into virions as a head fiber.
1. J Virol - published August 1, 2020
2. Guo YR, Fan Y, Zhou Y, Jin M, Zhang JL, Jiang H, Holt MV, Wang T, Young NL, Wang D, Zhong W, Tao YJ
Antigenicity and Immunogenicity of HIV-1 Envelope Trimers complexed to a Small-Molecule Viral Entry Inhibitor.
1. J Virol - published August 1, 2020
2. Alam SM, Cronin K, Parks R, Anasti K, Ding H, Go EP, Desaire H, Eaton A, Montefiori D, Sodroski J, Kappes J, Haynes BF, Saunders KO
Kinetics of receptor tyrosine kinase activation define ERK signaling dynamics.
1. Sci Signal - published August 1, 2020
2. Kiyatkin A, van Alderwerelt van Rosenburgh IK, Klein DE, Lemmon MA
Bedaquiline inhibits the yeast and human mitochondrial ATP synthases.
1. Commun Biol - published August 1, 2020
2. Luo M, Zhou W, Patel H, Srivastava AP, Symersky J, Bonar MM, Faraldo-Gómez JD, Liao M, Mueller DM
Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β₁-Adrenergic Receptor.
1. Mol Cell - published August 1, 2020
2. Su M, Zhu L, Zhang Y, Paknejad N, Dey R, Huang J, Lee MY, Williams D, Jordan KD, Eng ET, Ernst OP, Meyerson JR, Hite RK, Walz T, Liu W, Huang XY
Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo.
1. Cell Stem Cell - published August 1, 2020
2. Miao Y, Ha A, de Lau W, Yuki K, Santos AJM, You C, Geurts MH, Puschhof J, Pleguezuelos-Manzano C, Peng WC, Senlice R, Piani C, Buikema JW, Gbenedio OM, Vallon M, Yuan J, de Haan S, Hemrika W, Rösch K, Dang LT, Baker D, Ott M, Depeille P, Wu SM, Drost J, Nusse R, Roose JP, Piehler J, Boj SF, Janda CY, Clevers H, Kuo CJ, Garcia KC
A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers.
1. Proc Natl Acad Sci U S A - published August 1, 2020
2. Filipčík P, Latham SL, Cadell AL, Day CL, Croucher DR, Mace PD
Structural elucidation of the cis-prenyltransferase NgBR/DHDDS complex reveals insights in regulation of protein glycosylation.
1. Proc Natl Acad Sci U S A - published August 1, 2020
2. Edani BH, Grabińska KA, Zhang R, Park EJ, Siciliano B, Surmacz L, Ha Y, Sessa WC
Structure of the sodium-dependent phosphate transporter reveals insights into human solute carrier SLC20.
1. Sci Adv - published August 1, 2020
2. Tsai JY, Chu CH, Lin MG, Chou YH, Hong RY, Yen CY, Hsiao CD, Sun YJ
Two RSV Platforms for G, F, or G+F Proteins VLPs.
1. Viruses - published August 1, 2020
2. Ha B, Yang JE, Chen X, Jadhao SJ, Wright ER, Anderson LJ
Virtual Screening for Ligand Discovery at the σ₁ Receptor.
1. ACS Med Chem Lett - published August 1, 2020
2. Greenfield DA, Schmidt HR, Skiba MA, Mandler MD, Anderson JR, Sliz P, Kruse AC
Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers.
1. ACS Med Chem Lett - published August 1, 2020
2. Dolbois A, Batiste L, Wiedmer L, Dong J, Brütsch M, Huang D, Deerain NM, Spiliotopoulos D, Cheng-Sánchez I, Laul E, Nevado C, Śledź P, Caflisch A
Universal PCR and antibody testing demonstrate little to no transmission of SARS-CoV-2 in a rural community.
1. medRxiv - published August 1, 2020
2. Appa A, Takahashi S, Rodriguez-Barraquer I, Chamie G, Sawyer A, Consortium C, Duarte E, Hakim J, Turcios K, Vinden J, Janson O, Manglik A, Peluso MJ, Deeks SG, Henrich TJ, Torres L, Rodgers M, Hackett J, Chiu C, Havlir D, Greenhouse B
DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease.
1. Mol Cell - published August 1, 2020
2. Reinking HK, Kang HS, Götz MJ, Li HY, Kieser A, Zhao S, Acampora AC, Weickert P, Fessler E, Jae LT, Sattler M, Stingele J
Mutation of the second sialic acid-binding site of influenza A virus neuraminidase drives compensatory mutations in hemagglutinin.
1. PLoS Pathog - published August 1, 2020
2. Du W, Wolfert MA, Peeters B, van Kuppeveld FJM, Boons GJ, de Vries E, de Haan CAM
Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19.
1. Cell - published August 1, 2020
2. Kaneko N, Kuo HH, Boucau J, Farmer JR, Allard-Chamard H, Mahajan VS, Piechocka-Trocha A, Lefteri K, Osborn M, Bals J, Bartsch YC, Bonheur N, Caradonna TM, Chevalier J, Chowdhury F, Diefenbach TJ, Einkauf K, Fallon J, Feldman J, Finn KK, Garcia-Broncano P, Hartana CA, Hauser BM, Jiang C, Kaplonek P, Karpell M, Koscher EC, Lian X, Liu H, Liu J, Ly NL, Michell AR, Rassadkina Y, Seiger K, Sessa L, Shin S, Singh N, Sun W, Sun X, Ticheli HJ, Waring MT, Zhu AL, Alter G, Li JZ, Lingwood D, Schmidt AG, Lichterfeld M, Walker BD, Yu XG, Padera RF Jr, Pillai S, Massachusetts Consortium on Pathogen Readiness Specimen Working Group.
A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2.
1. Cell - published August 1, 2020
2. Hassan AO, Kafai NM, Dmitriev IP, Fox JM, Smith BK, Harvey IB, Chen RE, Winkler ES, Wessel AW, Case JB, Kashentseva E, McCune BT, Bailey AL, Zhao H, VanBlargan LA, Dai YN, Ma M, Adams LJ, Shrihari S, Danis JE, Gralinski LE, Hou YJ, Schäfer A, Kim AS, Keeler SP, Weiskopf D, Baric RS, Holtzman MJ, Fremont DH, Curiel DT, Diamond MS
Structure and assembly of ESCRT-III helical Vps24 filaments.
1. Sci Adv - published August 1, 2020
2. Huber ST, Mostafavi S, Mortensen SA, Sachse C
Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence.
1. Cell Discov - published August 1, 2020
2. Chi X, Jin X, Chen Y, Lu X, Tu X, Li X, Zhang Y, Lei J, Huang J, Huang Z, Zhou Q, Pan X