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165 Member Publications for July 2020

Prochlorococcus phage ferredoxin: structural characterization and electron transfer to cyanobacterial sulfite reductases.
1. J Biol Chem - published July 31, 2020
2. Campbell IJ, Olmos JL Jr, Xu W, Kahanda D, Atkinson JT, Sparks ON, Miller MD, Phillips GN Jr, Bennett GN, Silberg JJ
The Role of RNA Editing in the Immune Response.
1. Methods Mol Biol - published July 31, 2020
2. Ahmad S, Mu X, Hur S
IMPACT: Imaging phospholipase d activity with clickable alcohols via transphosphatidylation.
1. Methods Enzymol - published July 28, 2020
2. Bumpus TW, Liang D, Baskin JM
SHAPE Profiling to Probe Group II Intron Conformational Dynamics During Splicing.
1. Methods Mol Biol - published July 27, 2020
2. Wiryaman T, Toor N
Analysis of Multivalent IDP Interactions: Stoichiometry, Affinity, and Local Concentration Effect Measurements.
1. Methods Mol Biol - published July 23, 2020
2. Sparks S, Hayama R, Rout MP, Cowburn D
Children's rare disease cohorts: an integrative research and clinical genomics initiative.
1. NPJ Genom Med - published July 14, 2020
2. Rockowitz S, LeCompte N, Carmack M, Quitadamo A, Wang L, Park M, Knight D, Sexton E, Smith L, Sheidley B, Field M, Holm IA, Brownstein CA, Agrawal PB, Kornetsky S, Poduri A, Snapper SB, Beggs AH, Yu TW, Williams DA, Sliz P
West-Life: A Virtual Research Environment for structural biology.
1. J Struct Biol X - published July 11, 2020
2. Morris C, Andreetto P, Banci L, Bonvin AMJJ, Chojnowski G, Cano LD, Carazo JM, Conesa P, Daenke S, Damaskos G, Giachetti A, Haley NEC, Hekkelman ML, Heuser P, Joosten RP, Kouřil D, Křenek A, Kulhánek T, Lamzin VS, Nadzirin N, Perrakis A, Rosato A, Sanderson F, Segura J, Schaarschmidt J, Sobolev E, Traldi S, Trellet ME, Velankar S, Verlato M, Winn M
Measurement of local resolution in electron tomography.
1. J Struct Biol X - published July 11, 2020
2. Vilas JL, Oton J, Messaoudi C, Melero R, Conesa P, Ramirez-Aportela E, Mota J, Martinez M, Jimenez A, Marabini R, Carazo JM, Vargas J, Sorzano COS
CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection.
1. Cell - published July 9, 2020
2. Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ
Malignant tissues produce divergent antibody glycosylation of relevance for cancer gene therapy effectiveness.
1. MAbs - published July 9, 2020
2. Brücher D, Franc V, Smith SN, Heck AJR, Plückthun A
Need for Speed: From Human SARS-CoV-2 Samples to Protective and Efficacious Antibodies in Weeks.
1. Cell - published July 9, 2020
2. Joyce MG, Wheatley AK, Modjarrad K
Direct Relationship Between Increased Expression and Mistrafficking of the Charcot-Marie-Tooth-Associated Protein PMP22.
1. J Biol Chem - published July 9, 2020
2. Marinko JT, Carter BD, Sanders CR
Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2.
1. bioRxiv - published July 9, 2020
2. Nielsen SCA, Yang F, Jackson KJL, Hoh RA, Röltgen K, Stevens B, Lee JY, Rustagi A, Rogers AJ, Powell AE, Najeeb J, Otrelo-Cardoso AR, Yost KE, Daniel B, Chang HY, Satpathy AT, Jardetzky TS, Kim PS, Wang TT, Pinsky BA, Blish CA, Boyd SD
The Structural Basis for Kinetochore Stabilization by Cnn1/CENP-T.
1. Curr Biol - published July 9, 2020
2. Hinshaw SM, Harrison SC
Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor.
1. ACS Med Chem Lett - published July 9, 2020
2. Mpakali A, Saridakis E, Giastas P, Maben Z, Stern LJ, Larhed M, Hallberg M, Stratikos E
Escherichia coli NusG Links the Lead Ribosome with the Transcription Elongation Complex.
1. iScience - published July 9, 2020
2. Washburn RS, Zuber PK, Sun M, Hashem Y, Shen B, Li W, Harvey S, Acosta Reyes FJ, Gottesman ME, Knauer SH, Frank J
Diverse patterns of antibody variable gene repertoire disruption in patients with amyloid light chain (AL) amyloidosis.
1. PLoS One - published July 8, 2020
2. Chen EC, Rubinstein S, Soto C, Bombardi RG, Day SB, Myers L, Zaytsev A, Majedi M, Cornell RF, Crowe JE Jr
Protein crystals as a key for deciphering macromolecular crowding effects on biological reactions.
1. Phys Chem Chem Phys - published July 8, 2020
2. Ferreira C, Pinto MF, Macedo-Ribeiro S, Pereira PJB, Rocha FA, Martins PM
Irritant-evoked activation and calcium modulation of the TRPA1 receptor.
1. Nature - published July 8, 2020
2. Zhao J, Lin King JV, Paulsen CE, Cheng Y, Julius D
Group 2 Innate Lymphoid Cells Must Partner with the Myeloid-Macrophage Lineage for Long-Term Postviral Lung Disease.
1. J Immunol - published July 8, 2020
2. Wu K, Wang X, Keeler SP, Gerovac BJ, Agapov EV, Byers DE, Gilfillan S, Colonna M, Zhang Y, Holtzman MJ
L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins.
1. Proc Natl Acad Sci U S A - published July 8, 2020
2. Johnson MT, Gudlur A, Zhang X, Xin P, Emrich SM, Yoast RE, Courjaret R, Nwokonko RM, Li W, Hempel N, Machaca K, Gill DL, Hogan PG, Trebak M
Structural Investigation of 2-Naphthyl Phenyl Ether Inhibitors Bound to WT and Y181C Reverse Transcriptase Highlights Key Features of the NNRTI Binding Site.
1. Protein Sci - published July 8, 2020
2. Duong VN, Ippolito JA, Chan AH, Lee WG, Spasov KA, Jorgensen WL, Anderson KS
The N-terminal domain of Staphylothermus marinus McrB shares structural homology with PUA-like RNA binding proteins.
1. J Struct Biol - published July 8, 2020
2. Hosford CJ, Adams MC, Niu Y, Chappie JS
The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain.
1. Structure - published July 8, 2020
2. Jung T, Shin B, Tamo G, Kim H, Vijayvargia R, Leitner A, Marcaida MJ, Astorga-Wells J, Jung R, Aebersold R, Peraro MD, Hebert H, Seong IS, Song JJ
Continuous flexibility analysis of SARS-CoV-2 Spike prefusion structures.
1. bioRxiv - published July 8, 2020
2. Melero R, Sorzano COS, Foster B, Vilas JL, Martínez M, Marabini R, Ramírez-Aportela E, Sanchez-Garcia R, Herreros D, Del Caño L, Losana P, Fonseca-Reyna YC, Conesa P, Wrapp D, Chacon P, McLellan JS, Tagare HD, Carazo JM
Opinion: In the wake of COVID-19, academia needs new solutions to ensure gender equity.
1. Proc Natl Acad Sci U S A - published July 7, 2020
2. Malisch JL, Harris BN, Sherrer SM, Lewis KA, Shepherd SL, McCarthy PC, Spott JL, Karam EP, Moustaid-Moussa N, Calarco JM, Ramalingam L, Talley AE, Cañas-Carrell JE, Ardon-Dryer K, Weiser DA, Bernal XE, Deitloff J
Targeting Sphingosine Kinase by ABC294640 against Diffuse Intrinsic Pontine Glioma (DIPG).
1. J Cancer - published July 7, 2020
2. Dai L, Chen J, Lin Z, Wang Z, Mu S, Qin Z
Prevalence and pathogenicity of autoantibodies in patients with idiopathic CD4 lymphopenia.
1. J Clin Invest - published July 7, 2020
2. Perez-Diez A, Wong CS, Liu X, Mystakelis HA, Song J, Lu Y, Sheikh V, Bourgeois JS, Lisco A, Laidlaw E, Cudrici CD, Zhu C, Li QZ, Freeman AF, Williamson PR, Anderson MV, Roby G, Tsang JS, Siegel RM, Sereti I
When Less Is More: Combining Site-Specific Isotope Labeling and NMR Unravels Structural Details of Huntingtin Repeats.
1. Structure - published July 7, 2020
2. Delhommel F, Sattler M
Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner.
1. Cell Rep - published July 7, 2020
2. Gray S, Santiago ER, Chappie JS, Cohen PE
CcpNmr AnalysisScreen, a new software programme with dedicated automated analysis tools for fragment-based drug discovery by NMR.
1. J Biomol NMR - published July 7, 2020
2. Mureddu LG, Ragan TJ, Brooksbank EJ, Vuister GW
A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy.
1. J Cell Biol - published July 6, 2020
2. Fracchiolla D, Chang C, Hurley JH, Martens S
ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer.
1. J Cell Biol - published July 6, 2020
2. Shi X, Yokom AL, Wang C, Young LN, Youle RJ, Hurley JH
Trnp1 organizes diverse nuclear membrane-less compartments in neural stem cells.
1. EMBO J - published July 6, 2020
2. Esgleas M, Falk S, Forné I, Thiry M, Najas S, Zhang S, Mas-Sanchez A, Geerlof A, Niessing D, Wang Z, Imhof A, Götz M
Role of the activation peptide in the mechanism of protein C activation.
1. Sci Rep - published July 6, 2020
2. Stojanovski BM, Pelc LA, Di Cera E
A partially disordered region connects gene repression and activation functions of EZH2.
1. Proc Natl Acad Sci U S A - published July 6, 2020
2. Jiao L, Shubbar M, Yang X, Zhang Q, Chen S, Wu Q, Chen Z, Rizo J, Liu X
Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex.
1. Proc Natl Acad Sci U S A - published July 6, 2020
2. Bhargava HK, Tabata K, Byck JM, Hamasaki M, Farrell DP, Anishchenko I, DiMaio F, Im YJ, Yoshimori T, Hurley JH
The Tubulin Code in Microtubule Dynamics and Information Encoding.
1. Dev Cell - published July 6, 2020
2. Roll-Mecak A
DiB-splits: nature-guided design of a novel fluorescent labeling split system.
1. Sci Rep - published July 6, 2020
2. Bozhanova NG, Gavrikov AS, Mishin AS, Meiler J
Local resolution estimates of cryoEM reconstructions.
1. Curr Opin Struct Biol - published July 6, 2020
2. Vilas JL, Heymann JB, Tagare HD, Ramirez-Aportela E, Carazo JM, Sorzano C
Sex Differences in the Repair of Retinal Detachments in the United States.
1. Am J Ophthalmol - published July 5, 2020
2. Callaway NF, Vail D, Al-Moujahed A, Ludwig C, Ji MH, Mahajan VB, Pershing S, Moshfeghi DM
Anti-MUC1-C Antibody-conjugated Nanoparticles Potentiate the Efficacy of Fractionated Radiation Therapy.
1. Int J Radiat Oncol Biol Phys - published July 4, 2020
2. A D, C M, C J, M A, Mc D, Vl T, X P, F L, O T, D K, Pp G
Investigations of an inducible intact dystrophin gene excision system in cardiac and skeletal muscle in vivo.
1. Sci Rep - published July 3, 2020
2. Bez Batti Angulski A, Bauer J, Cohen H, Kobuke K, Campbell KP, Metzger JM
Structural insight into mitochondrial β-barrel outer membrane protein biogenesis.
1. Nat Commun - published July 3, 2020
2. Diederichs KA, Ni X, Rollauer SE, Botos I, Tan X, King MS, Kunji ERS, Jiang J, Buchanan SK
Probabilistic identification of saccharide moieties in biomolecules and their protein complexes.
1. Sci Data - published July 3, 2020
2. Dashti H, Westler WM, Wedell JR, Demler OV, Eghbalnia HR, Markley JL, Mora S
Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol.
1. Commun Biol - published July 3, 2020
2. Chabloz A, Schaefer JV, Kozieradzki I, Cronin SJF, Strebinger D, Macaluso F, Wald J, Rabbitts TH, Plückthun A, Marlovits TC, Penninger JM
Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease.
1. Sci Immunol - published July 3, 2020
2. Vogt MR, Fu J, Kose N, Williamson LE, Bombardi R, Setliff I, Georgiev IS, Klose T, Rossmann MG, Bochkov YA, Gern JE, Kuhn RJ, Crowe JE Jr
The secret life of histones.
1. Science - published July 3, 2020
2. Rudolph J, Luger K
Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques.
1. Nature - published July 3, 2020
2. Mercado NB, Zahn R, Wegmann F, Loos C, Chandrashekar A, Yu J, Liu J, Peter L, McMahan K, Tostanoski LH, He X, Martinez DR, Rutten L, Bos R, van Manen D, Vellinga J, Custers J, Langedijk JP, Kwaks T, Bakkers MJG, Zuijdgeest D, Huber SKR, Atyeo C, Fischinger S, Burke JS, Feldman J, Hauser BM, Caradonna TM, Bondzie EA, Dagotto G, Gebre MS, Hoffman E, Jacob-Dolan C, Kirilova M, Li Z, Lin Z, Mahrokhian SH, Maxfield LF, Nampanya F, Nityanandam R, Nkolola JP, Patel S, Ventura JD, Verrington K, Wan H, Pessaint L, Ry AV, Blade K, Strasbaugh A, Cabus M, Brown R, Cook A, Zouantchangadou S, Teow E, Andersen H, Lewis MG, Cai Y, Chen B, Schmidt AG, Reeves RK, Baric RS, Lauffenburger DA, Alter G, Stoffels P, Mammen M, Hoof JV, Schuitemaker H, Barouch DH
Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2.
1. Cell Host Microbe - published July 3, 2020
2. Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, Ustav M, Sidhu S, Virgin HW, Wang D, Ding S, Corti D, Theel ES, Fremont DH, Diamond MS, Whelan SPJ
Structural insights into differences in G protein activation by family A and family B GPCRs.
1. Science - published July 3, 2020
2. Hilger D, Kumar KK, Hu H, Pedersen MF, O'Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK
ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
1. Science - published July 3, 2020
2. Pinto PH, Kroupova A, Schleiffer A, Mechtler K, Jinek M, Weitzer S, Martinez J
MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma.
1. J Hepatol - published July 3, 2020
2. Komoll RM, Hu Q, Olarewaju O, von Döhlen L, Yuan Q, Xie Y, Tsay HC, Daon J, Qin R, Manns MP, Sharma AD, Goga A, Ott M, Balakrishnan A
Protein nanoribbons template enamel mineralization.
1. Proc Natl Acad Sci U S A - published July 3, 2020
2. Bai Y, Yu Z, Ackerman L, Zhang Y, Bonde J, Li W, Cheng Y, Habelitz S
Mechanisms of PI(4,5)P2 enrichment in HIV-1 viral membranes.
1. J Mol Biol - published July 3, 2020
2. Wen Y, Feigenson GW, Vogt VM, Dick RA
Molecular Mechanisms in Integral Membrane Enzymology.
1. J Mol Biol - published July 3, 2020
2. Li W, Bishop RE, Mancia F
Distinct Early Serological Signatures Track with SARS-CoV-2 Survival.
1. Immunity - published July 3, 2020
2. Atyeo C, Fischinger S, Zohar T, Slein MD, Burke J, Loos C, McCulloch DJ, Newman KL, Wolf C, Yu J, Shuey K, Feldman J, Hauser BM, Caradonna T, Schmidt AG, Suscovich TJ, Linde C, Cai Y, Barouch D, Ryan ET, Charles RC, Lauffenburger D, Chu H, Alter G
Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice.
1. Cell Host Microbe - published July 3, 2020
2. Case JB, Rothlauf PW, Chen RE, Kafai NM, Fox JM, Smith BK, Shrihari S, McCune BT, Harvey IB, Keeler SP, Bloyet LM, Zhao H, Ma M, Adams LJ, Winkler ES, Holtzman MJ, Fremont DH, Whelan SPJ, Diamond MS
ARIAweb: a server for automated NMR structure calculation.
1. Nucleic Acids Res - published July 2, 2020
2. Allain F, Mareuil F, Ménager H, Nilges M, Bardiaux B
Identification of Nonradiative Decay Pathways in Cy3.
1. J Phys Chem Lett - published July 2, 2020
2. Hart SM, Banal JL, Bathe M, Schlau-Cohen GS
Isolation and Characterization of Ice-Binding Proteins from Higher Plants.
1. Methods Mol Biol - published July 2, 2020
2. Bredow M, Tomalty HE, Graham LA, Gruneberg AK, Middleton AJ, Vanderbeld B, Davies PL, Walker VK
Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes.
1. Cell Stem Cell - published July 2, 2020
2. Buikema JW, Lee S, Goodyer WR, Maas RG, Chirikian O, Li G, Miao Y, Paige SL, Lee D, Wu H, Paik DT, Rhee S, Tian L, Galdos FX, Puluca N, Beyersdorf B, Hu J, Beck A, Venkamatran S, Swami S, Wijnker P, Schuldt M, Dorsch LM, van Mil A, Red-Horse K, Wu JY, Geisen C, Hesse M, Serpooshan V, Jovinge S, Fleischmann BK, Doevendans PA, van der Velden J, Garcia KC, Wu JC, Sluijter JPG, Wu SM
TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate.
1. Cell - published July 2, 2020
2. Venturutti L, Teater M, Zhai A, Chadburn A, Babiker L, Kim D, Béguelin W, Lee TC, Kim Y, Chin CR, Yewdell WT, Raught B, Phillip JM, Jiang Y, Staudt LM, Green MR, Chaudhuri J, Elemento O, Farinha P, Weng AP, Nissen MD, Steidl C, Morin RD, Scott DW, Privé GG, Melnick AM
Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation.
1. Proc Natl Acad Sci U S A - published July 2, 2020
2. Chan DTY, Jenkinson L, Haynes SW, Austin M, Diamandakis A, Burschowsky D, Seewooruthun C, Addyman A, Fiedler S, Ryman S, Whitehouse J, Slater LH, Gowans E, Shibata Y, Barnard M, Wilkinson RW, Vaughan TJ, Holt SV, Cerundolo V, Carr MD, Groves MAT
An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth.
1. Proc Natl Acad Sci U S A - published July 2, 2020
2. Vidimar V, Beilhartz GL, Park M, Biancucci M, Kieffer MB, Gius DR, Melnyk RA, Satchell KJF
Conformational Basis of G Protein-Coupled Receptor Signaling Versatility.
1. Trends Cell Biol - published July 2, 2020
2. Wingler LM, Lefkowitz RJ
Lockdown measures and relative changes in the age-specific incidence of SARS-CoV-2 in Spain.
1. medRxiv - published July 2, 2020
2. Salazar, D GB, D P, Jm G, B P, C FE, M L, A L, E G, Ma H
Challenging a Preconception: Optoacoustic Spectrum Differs from the Optical Absorption Spectrum of Proteins and Dyes for Molecular Imaging.
1. Anal Chem - published July 2, 2020
2. Fuenzalida Werner JP, Huang Y, Mishra K, Janowski R, Vetschera P, Heichler C, Chmyrov A, Neufert C, Niessing D, Ntziachristos V, Stiel AC
The Solvent-Exposed Fe-S D-Cluster Contributes to Oxygen-Resistance in Desulfovibrio vulgaris Ni-Fe Carbon Monoxide Dehydrogenase.
1. ACS Catal - published July 2, 2020
2. Wittenborn EC, Guendon C, Merrouch M, Benvenuti M, Fourmond V, Léger C, Drennan CL, Dementin S
Lipids: chemical tools for their synthesis, modification, and analysis.
1. Chem Soc Rev - published July 2, 2020
2. Flores J, White BM, Brea RJ, Baskin JM, Devaraj NK
Nanoparticles presenting clusters of CD4 expose a universal vulnerability of HIV-1 by mimicking target cells.
1. Proc Natl Acad Sci U S A - published July 2, 2020
2. Hoffmann MAG, Bar-On Y, Yang Z, Gristick HB, Gnanapragasam PNP, Vielmetter J, Nussenzweig MC, Bjorkman PJ
The Clinically Approved Antifungal Drug Posaconazole Inhibits Human Cytomegalovirus Replication.
1. Antimicrob Agents Chemother - published July 2, 2020
2. Mercorelli B, Luganini A, Celegato M, Palù G, Gribaudo G, Lepesheva GI, Loregian A
Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association.
1. Nat Microbiol - published July 2, 2020
2. Rabouw HH, Visser LJ, Passchier TC, Langereis MA, Liu F, Giansanti P, van Vliet ALW, Dekker JG, van der Grein SG, Saucedo JG, Anand AA, Trellet ME, Bonvin AMJJ, Walter P, Heck AJR, de Groot RJ, van Kuppeveld FJM
From Input to Output: The Lap/c-di-GMP Biofilm Regulatory Circuit.
1. Annu Rev Microbiol - published July 2, 2020
2. Collins AJ, Smith TJ, Sondermann H, O'Toole GA
Diffusible signal factors act through AraC-type transcriptional regulators as chemical cues to repress virulence of enteric pathogens.
1. Infect Immun - published July 2, 2020
2. Bosire EM, Eade CR, Schiltz CJ, Reid AJ, Troutman J, Chappie JS, Altier C
Genome-Scale Transcription-Translation Mapping Reveals Features of Zymomonas mobilis Transcription Units and Promoters.
1. mSystems - published July 2, 2020
2. Vera JM, Ghosh IN, Zhang Y, Hebert AS, Coon JJ, Landick R
Potent neutralizing antibodies directed to multiple epitopes on SARS-CoV-2 spike.
1. Nature - published July 2, 2020
2. Liu L, Wang P, Nair MS, Yu J, Rapp M, Wang Q, Luo Y, Chan JF, Sahi V, Figueroa A, Guo XV, Cerutti G, Bimela J, Gorman J, Zhou T, Chen Z, Yuen KY, Kwong PD, Sodroski JG, Yin MT, Sheng Z, Huang Y, Shapiro L, Ho DD
Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.
1. Cell Rep - published July 2, 2020
2. Yan W, Markegard E, Dharmaiah S, Urisman A, Drew M, Esposito D, Scheffzek K, Nissley DV, McCormick F, Simanshu DK
Electron tomography visualization of HIV-1 fusion with target cells using inhibitors to trap the prehairpin intermediate.
1. Elife - published July 2, 2020
2. Ladinsky MS, Gnanapragasam PNP, Yang Z, West AP, Kay MS, Bjorkman PJ
Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.
1. Cell Rep - published July 2, 2020
2. Koirala S, Klein J, Zheng Y, Glenn NO, Eisemann T, Fon Tacer K, Miller DJ, Kulak O, Lu M, Finkelstein DB, Neale G, Tillman H, Vogel P, Strand DW, Lum L, Brautigam CA, Pascal JM, Clements WK, Potts PR
Long-range intramolecular allostery and regulation in the dynein-like AAA protein Mdn1.
1. Proc Natl Acad Sci U S A - published July 2, 2020
2. Mickolajczyk KJ, Olinares PDB, Niu Y, Chen N, Warrington SE, Sasaki Y, Walz T, Chait BT, Kapoor TM
Distinct conformational states of SARS-CoV-2 spike protein.
1. Science - published July 2, 2020
2. Cai Y, Zhang J, Xiao T, Peng H, Sterling SM, Walsh RM Jr, Rawson S, Rits-Volloch S, Chen B
AMPA Receptor Auxiliary Subunit GSG1L Suppresses Short-Term Facilitation in Corticothalamic Synapses and Determines Seizure Susceptibility.
1. Cell Rep - published July 2, 2020
2. Kamalova A, Futai K, Delpire E, Nakagawa T
Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A.
1. Nat Commun - published July 2, 2020
2. Camacho-Zarco AR, Kalayil S, Maurin D, Salvi N, Delaforge E, Milles S, Jensen MR, Hart DJ, Cusack S, Blackledge M
Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation.
1. Sci Signal - published July 2, 2020
2. Sloutsky R, Dziedzic N, Dunn MJ, Bates RM, Torres-Ocampo AP, Boopathy S, Page B, Weeks JG, Chao LH, Stratton MM
Controlling the SARS-CoV-2 spike glycoprotein conformation.
1. Nat Struct Mol Biol - published July 2, 2020
2. Henderson R, Edwards RJ, Mansouri K, Janowska K, Stalls V, Gobeil SMC, Kopp M, Li D, Parks R, Hsu AL, Borgnia MJ, Haynes BF, Acharya P
Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance.
1. Nat Commun - published July 2, 2020
2. Deng Z, Maksaev G, Schlegel AM, Zhang J, Rau M, Fitzpatrick JAJ, Haswell ES, Yuan P
Whole-Exome Sequencing of Patients with Posterior Segment Uveitis.
1. Am J Ophthalmol - published July 2, 2020
2. Li AS, Velez G, Darbro B, Toral MA, Yang J, Tsang SH, Ferguson PJ, Folk JC, Bassuk AG, Mahajan VB
The crystal structures of a chloride-pumping microbial rhodopsin and its proton-pumping mutant illuminate proton transfer determinants.
1. J Biol Chem - published July 2, 2020
2. Besaw JE, Ou WL, Morizumi T, Eger BT, Sanchez Vasquez JD, Chu JHY, Harris A, Brown LS, Miller RJD, Ernst OP
A structural framework for unidirectional transport by a bacterial ABC exporter.
1. Proc Natl Acad Sci U S A - published July 2, 2020
2. Fan C, Kaiser JT, Rees DC
Opportunities, Barriers, and a Strategy for Overcoming Translational Challenges to Therapeutic Nucleic Acid Nanotechnology.
1. ACS Nano - published July 2, 2020
2. Afonin KA, Dobrovolskaia MA, Church G, Bathe M
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes.
1. Science - published July 2, 2020
2. Hsieh CL, Goldsmith JA, Schaub JM, DiVenere AM, Kuo HC, Javanmardi K, Le KC, Wrapp D, Lee AG, Liu Y, Chou CW, Byrne PO, Hjorth CK, Johnson NV, Ludes-Meyers J, Nguyen AW, Park J, Wang N, Amengor D, Lavinder JJ, Ippolito GC, Maynard JA, Finkelstein IJ, McLellan JS
Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine.
1. Nat Commun - published July 2, 2020
2. Lara J, Diacovich L, Trajtenberg F, Larrieux N, Malchiodi EL, Fernández MM, Gago G, Gramajo H, Buschiazzo A
Highly Conserved Molecular Features in IgLONs Contrast their Distinct Structural and Biological Outcomes.
1. J Mol Biol - published July 2, 2020
2. Venkannagari H, Kasper JM, Misra A, Rush SA, Fan S, Lee H, Sun H, Seshadrinathan S, Machius M, Hommel JD, Rudenko G
Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity.
1. Elife - published July 2, 2020
2. Mendoza JL, Fischer S, Gee MH, Lam LH, Brackenridge S, Powrie FM, Birnbaum M, McMichael AJ, Garcia KC, Gillespie GM
Cryo-electron microscopy of the chromatin fiber.
1. Curr Opin Struct Biol - published July 2, 2020
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Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes.
1. Nat Metab - published July 2, 2020
2. Cai EP, Ishikawa Y, Zhang W, Leite NC, Li J, Hou S, Kiaf B, Hollister-Lock J, Yilmaz NK, Schiffer CA, Melton DA, Kissler S, Yi P
Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd.
1. Nat Commun - published July 2, 2020
2. Brugger C, Zhang C, Suhanovsky MM, Kim DD, Sinclair AN, Lyumkis D, Deaconescu AM
The role of NMR in leveraging dynamics and entropy in drug design.
1. J Biomol NMR - published July 2, 2020
2. Dubey A, Takeuchi K, Reibarkh M, Arthanari H
Animal-derived-antibody generation faces strict reform in accordance with European Union policy on animal use.
1. Nat Methods - published July 2, 2020
2. Gray AC, Bradbury ARM, Knappik A, Plückthun A, Borrebaeck CAK, Dübel S
XMAP215 and γ-tubulin additively promote microtubule nucleation in purified solutions.
1. Mol Biol Cell - published July 2, 2020
2. King BR, Moritz M, Kim H, Agard DA, Asbury CL, Davis TN
Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy.
1. ACS Cent Sci - published July 2, 2020
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Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates.
1. N Engl J Med - published July 2, 2020
2. Corbett KS, Flynn B, Foulds KE, Francica JR, Boyoglu-Barnum S, Werner AP, Flach B, O'Connell S, Bock KW, Minai M, Nagata BM, Andersen H, Martinez DR, Noe AT, Douek N, Donaldson MM, Nji NN, Alvarado GS, Edwards DK, Flebbe DR, Lamb E, Doria-Rose NA, Lin BC, Louder MK, O'Dell S, Schmidt SD, Phung E, Chang LA, Yap C, Todd JM, Pessaint L, Van Ry A, Browne S, Greenhouse J, Putman-Taylor T, Strasbaugh A, Campbell TA, Cook A, Dodson A, Steingrebe K, Shi W, Zhang Y, Abiona OM, Wang L, Pegu A, Yang ES, Leung K, Zhou T, Teng IT, Widge A, Gordon I, Novik L, Gillespie RA, Loomis RJ, Moliva JI, Stewart-Jones G, Himansu S, Kong WP, Nason MC, Morabito KM, Ruckwardt TJ, Ledgerwood JE, Gaudinski MR, Kwong PD, Mascola JR, Carfi A, Lewis MG, Baric RS, McDermott A, Moore IN, Sullivan NJ, Roederer M, Seder RA, Graham BS
Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.
1. Nucleic Acids Res - published July 2, 2020
2. Lemeille S, Paschaki M, Baas D, Morlé L, Duteyrat JL, Ait-Lounis A, Barras E, Soulavie F, Jerber J, Thomas J, Zhang Y, Holtzman MJ, Kistler WS, Reith W, Durand B
Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations.
1. Elife - published July 2, 2020
2. Xue J, Xie T, Zeng W, Jiang Y, Bai XC
GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.
1. Mol Cell - published July 2, 2020
2. Hickey KL, Dickson K, Cogan JZ, Replogle JM, Schoof M, D'Orazio KN, Sinha NK, Hussmann JA, Jost M, Frost A, Green R, Weissman JS, Kostova KK
Author Correction: Structural insights into μ-opioid receptor activation.
1. Nature - published July 2, 2020
2. Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK
Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel.
1. J Biol Chem - published July 2, 2020
2. Burton MJ, Cresser-Brown J, Thomas M, Portolano N, Basran J, Freeman SL, Kwon H, Bottrill AR, Llansola-Portoles MJ, Pascal AA, Jukes-Jones R, Chernova T, Schmid R, Davies NW, Storey NM, Dorlet P, Moody PCE, Mitcheson JS, Raven EL
RORγ Structural Plasticity and Druggability.
1. Int J Mol Sci - published July 2, 2020
2. Huang M, Bolin S, Miller H, Ng HL
Structural interpretation of cryo-EM image reconstructions.
1. Prog Biophys Mol Biol - published July 2, 2020
2. Beckers M, Mann D, Sachse C
Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED.
1. Structure - published July 2, 2020
2. Zhu L, Bu G, Jing L, Shi D, Lee MY, Gonen T, Liu W, Nannenga BL
Dynamics and significance of the antibody response to SARS-CoV-2 infection.
1. medRxiv - published July 2, 2020
2. Iyer AS, Jones FK, Nodoushani A, Kelly M, Becker M, Slater D, Mills R, Teng E, Kamruzzaman M, Garcia-Beltran WF, Astudillo M, Yang D, Miller TE, Oliver E, Fischinger S, Atyeo C, Iafrate AJ, Calderwood SB, Lauer SA, Yu J, Li Z, Feldman J, Hauser BM, Caradonna TM, Branda JA, Turbett SE, LaRocque RC, Mellon G, Barouch DH, Schmidt AG, Azman AS, Alter G, Ryan ET, Harris JB, Charles RC
3D Printed frames to enable reuse and improve the fit of N95 and KN95 respirators.
1. medRxiv - published July 2, 2020
2. McAvoy M, Bui AN, Hansen C, Plana D, Said JT, Yu Z, Yang H, Freake J, Van C, Krikorian D, Cramer A, Smith L, Jiang L, Lee KJ, Li SJ, Beller B, Short M, Yu SH, Mostaghimi A, Sorger PK, LeBoeuf NR
Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor.
1. bioRxiv - published July 2, 2020
2. Zhao P, Praissman JL, Grant OC, Cai Y, Xiao T, Rosenbalm KE, Aoki K, Kellman BP, Bridger R, Barouch DH, Brindley MA, Lewis NE, Tiemeyer M, Chen B, Woods RJ, Wells L
Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes.
1. SSRN - published July 2, 2020
2. Zhou T, Teng IT, Olia AS, Cerutti G, Gorman J, Nazzari A, Shi W, Tsybovsky Y, Wang L, Wang S, Zhang B, Zhang Y, Katsamba PS, Petrova Y, Banach BB, Fahad AS, Liu L, Acevedo SNL, Madan B, de Souza MO, Pan X, Wang P, Wolfe JR, Yin M, Ho DD, Phung E, DiPiazza A, Chang L, Abiona O, Corbett KS, DeKosky BJ, Graham BS, Mascola JR, Misasi J, Ruckwardt T, Sullivan NJ, Shapiro L, Kwong PD
A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2.
1. Cell Rep - published July 2, 2020
2. Liu YM, Shahed-Al-Mahmud M, Chen X, Chen TH, Liao KS, Lo JM, Wu YM, Ho MC, Wu CY, Wong CH, Jan JT, Ma C
Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex.
1. Cell - published July 2, 2020
2. Chen J, Malone B, Llewellyn E, Grasso M, Shelton PMM, Olinares PDB, Maruthi K, Eng ET, Vatandaslar H, Chait BT, Kapoor TM, Darst SA, Campbell EA
Rapid and accurate species identification for ecological studies and monitoring using CRISPR-based SHERLOCK.
1. Mol Ecol Resour - published July 1, 2020
2. Baerwald MR, Goodbla AM, Nagarajan RP, Gootenberg JS, Abudayyeh OO, Zhang F, Schreier AD
RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling.
1. J Biol Chem - published July 1, 2020
2. Nelson AC, Turbyville TJ, Dharmaiah S, Rigby M, Yang R, Wang TY, Columbus J, Stephens R, Taylor T, Sciacca D, Onsongo G, Sarver A, Subramanian S, Nissley DV, Simanshu DK, Lou E
Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium.
1. bioRxiv - published July 1, 2020
2. Ravindra NG, Alfajaro MM, Gasque V, Habet V, Wei J, Filler RB, Huston NC, Wan H, Szigeti-Buck K, Wang B, Wang G, Montgomery RR, Eisenbarth SC, Williams A, Pyle AM, Iwasaki A, Horvath TL, Foxman EF, Pierce RW, van Dijk D, Wilen CB
A Stable Ferryl Porphyrin at the Active Site of Y463M BthA.
1. J Am Chem Soc - published July 1, 2020
2. Rizzolo K, Weitz AC, Cohen SE, Drennan CL, Hendrich MP, Elliott SJ
Identifying Structural Determinants of Product Specificity in Leishmania major Farnesyl Diphosphate Synthase.
1. Biochemistry - published July 1, 2020
2. Maheshwari S, Kim YS, Aripirala S, Murphy M, Amzel LM, Gabelli SB
Dominant role of αIIbβ3 in platelet interactions with cross-linked fibrin fragment D-dimer.
1. Blood Adv - published July 1, 2020
2. Buitrago L, Zafar H, Zhang Y, Li J, Walz T, Coller BS
Inhibition of O-GlcNAc transferase renders prostate cancer cells dependent on CDK9.
1. Mol Cancer Res - published July 1, 2020
2. Itkonen HM, Poulose N, Steele RE, Martin SES, Levine ZG, Duveau DY, Carelli R, Singh R, Urbanucci A, Loda M, Thomas CJ, Mills IG, Walker S
Clinical targeting of HIV capsid protein with a long-acting small molecule.
1. Nature - published July 1, 2020
2. Link JO, Rhee MS, Tse WC, Zheng J, Somoza JR, Rowe W, Begley R, Chiu A, Mulato A, Hansen D, Singer E, Tsai LK, Bam RA, Chou CH, Canales E, Brizgys G, Zhang JR, Li J, Graupe M, Morganelli P, Liu Q, Wu Q, Halcomb RL, Saito RD, Schroeder SD, Lazerwith SE, Bondy S, Jin D, Hung M, Novikov N, Liu X, Villaseñor AG, Cannizzaro CE, Hu EY, Anderson RL, Appleby TC, Lu B, Mwangi J, Liclican A, Niedziela-Majka A, Papalia GA, Wong MH, Leavitt SA, Xu Y, Koditek D, Stepan GJ, Yu H, Pagratis N, Clancy S, Ahmadyar S, Cai TZ, Sellers S, Wolckenhauer SA, Ling J, Callebaut C, Margot N, Ram RR, Liu YP, Hyland R, Sinclair GI, Ruane PJ, Crofoot GE, McDonald CK, Brainard DM, Lad L, Swaminathan S, Sundquist WI, Sakowicz R, Chester AE, Lee WE, Daar ES, Yant SR, Cihlar T
Making a difference in multi-data-set crystallography: simple and deterministic data-scaling/selection methods.
1. Acta Crystallogr D Struct Biol - published July 1, 2020
2. Assmann GM, Wang M, Diederichs K
Targeted Brain Tumor Therapy by Inhibiting the MDM2 Oncogene: In Vitro and In Vivo Antitumor Activity and Mechanism of Action.
1. Cells - published July 1, 2020
2. Punganuru SR, Artula V, Zhao W, Rajaei M, Deokar H, Zhang R, Buolamwini JK, Srivenugopal KS, Wang W
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
1. bioRxiv - published July 1, 2020
2. Yurkovetskiy L, Wang X, Pascal KE, Tomkins-Tinch C, Nyalile T, Wang Y, Baum A, Diehl WE, Dauphin A, Carbone C, Veinotte K, Egri SB, Schaffner SF, Lemieux JE, Munro J, Rafique A, Barve A, Sabeti PC, Kyratsous CA, Dudkina N, Shen K, Luban J
Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP.
1. Elife - published July 1, 2020
2. Klug D, Goellner S, Kehrer J, Sattler J, Strauss L, Singer M, Lu C, Springer TA, Frischknecht F
The potential impacts of early secreted antigenic target of 6 kDa (ESAT-6) of Mycobacterium tuberculosis on KSHV-infected cells.
1. J Med Virol - published July 1, 2020
2. Dai L, Jung BG, Chen J, Samten B, Forrest JC, Post SR, Qin Z
Structure and selectivity engineering of the M1 muscarinic receptor toxin complex.
1. Science - published July 1, 2020
2. Maeda S, Xu J, N Kadji FM, Clark MJ, Zhao J, Tsutsumi N, Aoki J, Sunahara RK, Inoue A, Garcia KC, Kobilka BK
The precious fluorine on the ring: fluorine NMR for biological systems.
1. J Biomol NMR - published July 1, 2020
2. Boeszoermenyi A, Ogórek B, Jain A, Arthanari H, Wagner G
Modular microfluidics enables kinetic insight from time-resolved cryo-EM.
1. Nat Commun - published July 1, 2020
2. Mäeots ME, Lee B, Nans A, Jeong SG, Esfahani MMN, Ding S, Smith DJ, Lee CS, Lee SS, Peter M, Enchev RI
Tract-specific analysis improves sensitivity of spinal cord diffusion MRI to cross-sectional and longitudinal changes in amyotrophic lateral sclerosis.
1. Commun Biol - published July 1, 2020
2. Pisharady PK, Eberly LE, Cheong I, Manousakis G, Guliani G, Clark HB, Bathe M, Walk D, Lenglet C
MDM2 inhibition: an important step forward in cancer therapy.
1. Leukemia - published July 1, 2020
2. Konopleva M, Martinelli G, Daver N, Papayannidis C, Wei A, Higgins B, Ott M, Mascarenhas J, Andreeff M
Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein.
1. Nat Med - published July 1, 2020
2. Zost SJ, Gilchuk P, Chen RE, Case JB, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Chen EC, Binshtein E, Shrihari S, Ostrowski M, Chu HY, Didier JE, MacRenaris KW, Jones T, Day S, Myers L, Eun-Hyung Lee F, Nguyen DC, Sanz I, Martinez DR, Rothlauf PW, Bloyet LM, Whelan SPJ, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe JE Jr
Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans.
1. Proc Natl Acad Sci U S A - published July 1, 2020
2. Ellebedy AH, Nachbagauer R, Jackson KJL, Dai YN, Han J, Alsoussi WB, Davis CW, Stadlbauer D, Rouphael N, Chromikova V, McCausland M, Chang CY, Cortese M, Bower M, Chennareddy C, Schmitz AJ, Zarnitsyna VI, Lai L, Rajabhathor A, Kazemian C, Antia R, Mulligan MJ, Ward AB, Fremont DH, Boyd SD, Pulendran B, Krammer F, Ahmed R
A redox switch regulates the structure and function of anti-apoptotic BFL-1.
1. Nat Struct Mol Biol - published July 1, 2020
2. Korshavn KJ, Wales TE, Bird GH, Engen JR, Walensky LD
Histone acetyl transferase MOF orchestrates outcomes at the crossroad of oncogenesis, DNA damage response, proliferation, and stem cell development.
1. Mol Cell Biol - published July 1, 2020
2. Singh M, Bacolla A, Chaudhary S, Hunt CR, Pandita S, Chauhan R, Gupta A, Tainer JA, Pandita TK
Author Correction: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.
1. Nat Med - published July 1, 2020
2. Menachery VD, Yount BL Jr, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS
Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression.
1. PLoS Pathog - published July 1, 2020
2. Visser LJ, Aloise C, Swatek KN, Medina GN, Olek KM, Rabouw HH, de Groot RJ, Langereis MA, de Los Santos T, Komander D, Skern T, van Kuppeveld FJM
Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2.
1. Elife - published July 1, 2020
2. Wang C, Jacewicz A, Delgado BD, Baradaran R, Long SB
Potently neutralizing and protective human antibodies against SARS-CoV-2.
1. Nature - published July 1, 2020
2. Zost SJ, Gilchuk P, Case JB, Binshtein E, Chen RE, Nkolola JP, Schäfer A, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Martinez DR, Williamson LE, Chen EC, Jones T, Day S, Myers L, Hassan AO, Kafai NM, Winkler ES, Fox JM, Shrihari S, Mueller BK, Meiler J, Chandrashekar A, Mercado NB, Steinhardt JJ, Ren K, Loo YM, Kallewaard NL, McCune BT, Keeler SP, Holtzman MJ, Barouch DH, Gralinski LE, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe JE Jr
Author Correction: Structure of human GABAB receptor in an inactive state.
1. Nature - published July 1, 2020
2. Park J, Fu Z, Frangaj A, Liu J, Mosyak L, Shen T, Slavkovich VN, Ray KM, Taura J, Cao B, Geng Y, Zuo H, Kou Y, Grassucci R, Chen S, Liu Z, Lin X, Williams JP, Rice WJ, Eng ET, Huang RK, Soni RK, Kloss B, Yu Z, Javitch JA, Hendrickson WA, Slesinger PA, Quick M, Graziano J, Yu H, Fiehn O, Clarke OB, Frank J, Fan QR
High Frequency of Shared Clonotypes in Human T Cell Receptor Repertoires.
1. Cell Rep - published July 1, 2020
2. Soto C, Bombardi RG, Kozhevnikov M, Sinkovits RS, Chen EC, Branchizio A, Kose N, Day SB, Pilkinton M, Gujral M, Mallal S, Crowe JE Jr
Structure-based development of a subtype-selective orexin 1 receptor antagonist.
1. Proc Natl Acad Sci U S A - published July 1, 2020
2. Hellmann J, Drabek M, Yin J, Gunera J, Pröll T, Kraus F, Langmead CJ, Hübner H, Weikert D, Kolb P, Rosenbaum DM, Gmeiner P
Opportunities and challenges for the clinical translation of structured DNA assemblies as gene therapeutic delivery and vaccine vectors.
1. Wiley Interdiscip Rev Nanomed Nanobiotechnol - published July 1, 2020
2. Dobrovolskaia MA, Bathe M
Humoral Immunity to Hantavirus Infection.
1. mSphere - published July 1, 2020
2. Engdahl TB, Crowe JE Jr
Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex.
1. bioRxiv - published July 1, 2020
2. Chen J, Malone B, Llewellyn E, Grasso M, Shelton PMM, Olinares PDB, Maruthi K, Eng E, Vatandaslar H, Chait BT, Kapoor T, Darst SA, Campbell EA
Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis.
1. Mol Cell - published July 1, 2020
2. Jaskolowski M, Ramrath DJF, Bieri P, Niemann M, Mattei S, Calderaro S, Leibundgut M, Horn EK, Boehringer D, Schneider A, Ban N
PyIR: a scalable wrapper for processing billions of immunoglobulin and T cell receptor sequences using IgBLAST.
1. BMC Bioinformatics - published July 1, 2020
2. Soto C, Finn JA, Willis JR, Day SB, Sinkovits RS, Jones T, Schmitz S, Meiler J, Branchizio A, Crowe JE Jr
Comprehensive in-vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms.
1. bioRxiv - published July 1, 2020
2. Huston NC, Wan H, de Cesaris Araujo Tavares R, Wilen C, Pyle AM
Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis.
1. bioRxiv - published July 1, 2020
2. Case JB, Rothlauf PW, Chen RE, Kafai NM, Fox JM, Shrihari S, McCune BT, Harvey IB, Smith B, Keeler SP, Bloyet LM, Winkler ES, Holtzman MJ, Fremont DH, Whelan SPJ, Diamond MS
Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.
1. Nat Commun - published July 1, 2020
2. Arragain B, Effantin G, Gerlach P, Reguera J, Schoehn G, Cusack S, Malet H
Methyltransferase contingencies in the pathway of everninomicin D antibiotics and analogs.
1. Chembiochem - published July 1, 2020
2. Limbrick EM, Ynigez-Gutierrez AE, Dulin CC, Derewacz DK, Spraggins JM, McCulloch KM, Iverson TM, Bachmann BO
De Novo Variants in the ATPase Module of MORC2 Cause a Neurodevelopmental Disorder with Growth Retardation and Variable Craniofacial Dysmorphism.
1. Am J Hum Genet - published July 1, 2020
2. Guillen Sacoto MJ, Tchasovnikarova IA, Torti E, Forster C, Andrew EH, Anselm I, Baranano KW, Briere LC, Cohen JS, Craigen WJ, Cytrynbaum C, Ekhilevitch N, Elrick MJ, Fatemi A, Fraser JL, Gallagher RC, Guerin A, Haynes D, High FA, Inglese CN, Kiss C, Koenig MK, Krier J, Lindstrom K, Marble M, Meddaugh H, Moran ES, Morel CF, Mu W, Muller EA 2nd, Nance J, Natowicz MR, Numis AL, Ostrem B, Pappas J, Stafstrom CE, Streff H, Sweetser DA, Szybowska M, Undiagnosed Diseases Network., Walker MA, Wang W, Weiss K, Weksberg R, Wheeler PG, Yoon G, Kingston RE, Juusola J
Permutation testing of Fourier shell correlation for resolution estimation of cryo-EM maps.
1. J Struct Biol - published July 1, 2020
2. Beckers M, Sachse C
Paired refinement under the control of PAIREF.
1. IUCrJ - published July 1, 2020
2. Malý M, Diederichs K, Dohnálek J, Kolenko P
Dual targeting of GSK3B and HDACs reduces tumor growth and improves survival in an ovarian cancer mouse model.
1. Gynecol Oncol - published July 1, 2020
2. Taylan E, Zayou F, Murali R, Karlan BY, Pandol SJ, Edderkaoui M, Orsulic S
Nickel and GTP Modulate Helicobacter pylori UreG Structural Flexibility.
1. Biomolecules - published July 1, 2020
2. Pierro A, Etienne E, Gerbaud G, Guigliarelli B, Ciurli S, Belle V, Zambelli B, Mileo E
The Loss of Bcl-6 Expressing T Follicular Helper Cells and the Absence of Germinal Centers in COVID-19.
1. SSRN - published July 1, 2020
2. Kaneko N, Kuo HH, Boucau J, Farmer JR, Allard-Chamard H, Mahajan VS, Piechocka-Trocha A, Lefteri K, Osborn M, Bals J, Bartsch YC, Bonheur N, Caradonna TM, Chevalier J, Chowdhury F, Diefenbach TJ, Einkauf K, Fallon J, Feldman J, Finn KK, Garcia-Broncano P, Hartana CA, Hauser BM, Jiang C, Kaplonek P, Karpell M, Koscher EC, Lian X, Liu H, Liu J, Ly NL, Michell AR, Rassadkina Y, Seiger K, Sessa L, Shin S, Singh N, Sun W, Sun X, Ticheli HJ, Waring MT, Zhu AL, Li J, Lingwood D, Schmidt AG, Lichterfeld M, Walker BD, Yu X, Padera RF, Pillai S, Group MCOPRSW
A Searchable Database of Crystallization Cocktails in the PDB: Analyzing the Chemical Condition Space.
1. Patterns (N Y) - published July 1, 2020
2. Lynch ML, Dudek MF, Bowman SEJ
Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM.
1. Sci Adv - published July 1, 2020
2. Iyer KA, Hu Y, Nayak AR, Kurebayashi N, Murayama T, Samsó M
Crystal structure of the human oxytocin receptor.
1. Sci Adv - published July 1, 2020
2. Waltenspühl Y, Schöppe J, Ehrenmann J, Kummer L, Plückthun A
Computational Methods for Single-Particle Electron Cryomicroscopy.
1. Annu Rev Biomed Data Sci - published July 1, 2020
2. Singer A, Sigworth FJ