Member Publications

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121 Member Publications for May 2020

How Actin Tracks Affect Myosin Motors.
1. Adv Exp Med Biol - published May 27, 2020
2. Santos A, Shauchuk Y, Cichoń U, Vavra KC, Rock RS
Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome.
1. Front Pharmacol - published May 21, 2020
2. Brewer KR, Kuenze G, Vanoye CG, George AL Jr, Meiler J, Sanders CR
Cryo-Electron Microscopy Structures of the Pneumoviridae Polymerases.
1. Viral Immunol - published May 21, 2020
2. Cao D, Liang B
Human-likeness of antibody biologics determined by back-translation and comparison with large antibody variable gene repertoires.
1. MAbs - published May 14, 2020
2. Schmitz S, Soto C, Crowe JE Jr, Meiler J
Lysine succinylation and SIRT5 couple nutritional status to glutamine catabolism.
1. Mol Cell Oncol - published May 12, 2020
2. Lukey MJ, Greene KS, Cerione RA
XynDZ5: A New Thermostable GH10 Xylanase.
1. Front Microbiol - published May 12, 2020
2. Zarafeta D, Galanopoulou AP, Leni ME, Kaili SI, Chegkazi MS, Chrysina ED, Kolisis FN, Hatzinikolaou DG, Skretas G
Characterization of a human monoclonal antibody generated from a B-cell specific for a prefusion-stabilized spike protein of Middle East respiratory syndrome coronavirus.
1. PLoS One - published May 9, 2020
2. Choi JH, Woo HM, Lee TY, Lee SY, Shim SM, Park WJ, Yang JS, Kim JA, Yun MR, Kim DW, Kim SS, Zhang Y, Shi W, Wang L, Graham BS, Mascola JR, Wang N, McLellan JS, Lee JY, Lee H
Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core.
1. J Med Chem - published May 8, 2020
2. Liosi ME, Krimmer SG, Newton AS, Dawson TK, Puleo DE, Cutrona KJ, Suzuki Y, Schlessinger J, Jorgensen WL
Diversity in kinetics correlated with structure in nano body-stabilized LacY.
1. PLoS One - published May 8, 2020
2. Kumar H, Finer-Moore J, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM
Structural basis of transmembrane coupling of the HIV-1 envelope glycoprotein.
1. Nat Commun - published May 8, 2020
2. Piai A, Fu Q, Cai Y, Ghantous F, Xiao T, Shaik MM, Peng H, Rits-Volloch S, Chen W, Seaman MS, Chen B, Chou JJ
ABCG2 transports anticancer drugs via a closed-to-open switch.
1. Nat Commun - published May 8, 2020
2. Orlando BJ, Liao M
Nanoadhesive layer to prevent protein absorption in a poly(dimethylsiloxane) microfluidic device.
1. Biotechniques - published May 6, 2020
2. You JB, Lee B, Choi Y, Lee CS, Peter M, Im SG, Lee SS
Cryo-EM structures and functional properties of CALHM channels of the human placenta.
1. Elife - published May 6, 2020
2. Drożdżyk K, Sawicka M, Bahamonde-Santos MI, Jonas Z, Deneka D, Albrecht C, Dutzler R
Yeast pericentrin/Spc110 contains multiple domains required for tethering the gamma tubulin complex to the centrosome.
1. Mol Biol Cell - published May 6, 2020
2. Alonso A, Fabritius A, Ozzello C, Andreas M, Klenchin D, Rayment I, Winey M
Methylation deficiency disrupts biological rhythms from bacteria to humans.
1. Commun Biol - published May 6, 2020
2. Fustin JM, Ye S, Rakers C, Kaneko K, Fukumoto K, Yamano M, Versteven M, Grünewald E, Cargill SJ, Tamai TK, Xu Y, Jabbur ML, Kojima R, Lamberti ML, Yoshioka-Kobayashi K, Whitmore D, Tammam S, Howell PL, Kageyama R, Matsuo T, Stanewsky R, Golombek DA, Johnson CH, Kakeya H, van Ooijen G, Okamura H
Lactoferrin-hexon interactions mediate CAR-independent adenovirus infection of human respiratory cells.
1. J Virol - published May 6, 2020
2. Persson BD, Lenman A, Frängsmyr L, Schmidt M, Ahlm C, Plückthun A, Jenssen H, Arnberg N
Elevator-type mechanisms of membrane transport.
1. Biochem Soc Trans - published May 5, 2020
2. Garaeva AA, Slotboom DJ
Conserved Outer Tegument Component UL11 from Herpes Simplex Virus 1 Is an Intrinsically Disordered, RNA-Binding Protein.
1. mBio - published May 5, 2020
2. Metrick CM, Koenigsberg AL, Heldwein EE
Finally on Track: Interactions of Off-Track with Plex-Sema Pathway and Glycosaminoglycans.
1. Structure - published May 5, 2020
2. Cheng S, Özkan E
Discovery of Ubonodin, an Antimicrobial Lasso Peptide Active against Members of the Burkholderia cepacia Complex.
1. Chembiochem - published May 4, 2020
2. Cheung-Lee WL, Parry ME, Zong C, Cartagena AJ, Darst SA, Connell ND, Russo R, Link AJ
Trib1 regulates T cell differentiation during chronic infection by restraining the effector program.
1. J Exp Med - published May 4, 2020
2. Rome KS, Stein SJ, Kurachi M, Petrovic J, Schwartz GW, Mack EA, Uljon S, Wu WW, DeHart AG, McClory SE, Xu L, Gimotty PA, Blacklow SC, Faryabi RB, Wherry EJ, Jordan MS, Pear WS
Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes.
1. J Cell Biol - published May 4, 2020
2. Li P, Lees JA, Lusk CP, Reinisch KM
Golgi-associated BICD adaptors couple ER membrane penetration and disassembly of a viral cargo.
1. J Cell Biol - published May 4, 2020
2. Spriggs CC, Badieyan S, Verhey KJ, Cianfrocco MA, Tsai B
A firehose for phospholipids.
1. J Cell Biol - published May 4, 2020
2. Prinz WA, Hurley JH
Human monoclonal antibodies against Ross River virus target epitopes within the E2 protein and protect against disease.
1. PLoS Pathog - published May 4, 2020
2. Powell LA, Fox JM, Kose N, Kim AS, Majedi M, Bombardi R, Carnahan RH, Slaughter JC, Morrison TE, Diamond MS, Crowe JE Jr
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation.
1. Nat Immunol - published May 4, 2020
2. Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, Kim J, Lieberman J, Wu H
Transferrin binding protein B and Transferrin binding protein A 2 expand the transferrin recognition range of Histophilus somni.
1. J Bacteriol - published May 4, 2020
2. Pogoutse AK, Moraes TF
Site-specific glycan analysis of the SARS-CoV-2 spike.
1. Science - published May 4, 2020
2. Watanabe Y, Allen JD, Wrapp D, McLellan JS, Crispin M
A human monoclonal antibody blocking SARS-CoV-2 infection.
1. Nat Commun - published May 4, 2020
2. Wang C, Li W, Drabek D, Okba NMA, van Haperen R, Osterhaus ADME, van Kuppeveld FJM, Haagmans BL, Grosveld F, Bosch BJ
The Structure-Function Relationship of Angular Estrogens and Estrogen Receptor Alpha to Initiate Estrogen-Induced Apoptosis in Breast Cancer Cells.
1. Mol Pharmacol - published May 3, 2020
2. Maximov PY, Abderrahman B, Hawsawi YM, Chen Y, Foulds CE, Jain A, Malovannaya A, Fan P, Curpan RF, Han R, Fanning SW, Broom BM, Quintana Rincon DM, Greenland JA, Greene GL, Jordan VC
The large family of PC4-like domains - similar folds and functions throughout all kingdoms of life.
1. RNA Biol - published May 3, 2020
2. Janowski R, Niessing D
Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes.
1. bioRxiv - published May 3, 2020
2. Hsieh CL, Goldsmith JA, Schaub JM, DiVenere AM, Kuo HC, Javanmardi K, Le KC, Wrapp D, Lee AG, Liu Y, Chou CW, Byrne PO, Hjorth CK, Johnson NV, Ludes-Meyers J, Nguyen AW, Park J, Wang N, Amengor D, Maynard JA, Finkelstein IJ, McLellan JS
Highly Parallel Profiling of Cas9 Variant Specificity.
1. Mol Cell - published May 2, 2020
2. Schmid-Burgk JL, Gao L, Li D, Gardner Z, Strecker J, Lash B, Zhang F
Hydrocarbon-Stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor.
1. ACS Chem Biol - published May 2, 2020
2. Bird GH, Fu A, Escudero S, Godes M, Opoku-Nsiah K, Wales TE, Cameron MD, Engen JR, Danial NN, Walensky LD
Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities.
1. Nat Commun - published May 2, 2020
2. Nichols CA, Gibson WJ, Brown MS, Kosmicki JA, Busanovich JP, Wei H, Urbanski LM, Curimjee N, Berger AC, Gao GF, Cherniack AD, Dhe-Paganon S, Paolella BR, Beroukhim R
Immunogenicity of a DNA vaccine candidate for COVID-19.
1. Nat Commun - published May 2, 2020
2. Smith TRF, Patel A, Ramos S, Elwood D, Zhu X, Yan J, Gary EN, Walker SN, Schultheis K, Purwar M, Xu Z, Walters J, Bhojnagarwala P, Yang M, Chokkalingam N, Pezzoli P, Parzych E, Reuschel EL, Doan A, Tursi N, Vasquez M, Choi J, Tello-Ruiz E, Maricic I, Bah MA, Wu Y, Amante D, Park DH, Dia Y, Ali AR, Zaidi FI, Generotti A, Kim KY, Herring TA, Reeder S, Andrade VM, Buttigieg K, Zhao G, Wu JM, Li D, Bao L, Liu J, Deng W, Qin C, Brown AS, Khoshnejad M, Wang N, Chu J, Wrapp D, McLellan JS, Muthumani K, Wang B, Carroll MW, Kim JJ, Boyer J, Kulp DW, Humeau LMPF, Weiner DB, Broderick KE
Competitive tight-binding inhibition of VKORC1 underlies warfarin dosage variation and antidotal efficacy.
1. Blood Adv - published May 2, 2020
2. Li S, Liu S, Liu XR, Zhang MM, Li W
DNA vaccine protection against SARS-CoV-2 in rhesus macaques.
1. Science - published May 2, 2020
2. Yu J, Tostanoski LH, Peter L, Mercado NB, McMahan K, Mahrokhian SH, Nkolola JP, Liu J, Li Z, Chandrashekar A, Martinez DR, Loos C, Atyeo C, Fischinger S, Burke JS, Slein MD, Chen Y, Zuiani A, N Lelis FJ, Travers M, Habibi S, Pessaint L, Van Ry A, Blade K, Brown R, Cook A, Finneyfrock B, Dodson A, Teow E, Velasco J, Zahn R, Wegmann F, Bondzie EA, Dagotto G, Gebre MS, He X, Jacob-Dolan C, Kirilova M, Kordana N, Lin Z, Maxfield LF, Nampanya F, Nityanandam R, Ventura JD, Wan H, Cai Y, Chen B, Schmidt AG, Wesemann DR, Baric RS, Alter G, Andersen H, Lewis MG, Barouch DH
SARS-CoV-2 infection protects against rechallenge in rhesus macaques.
1. Science - published May 2, 2020
2. Chandrashekar A, Liu J, Martinot AJ, McMahan K, Mercado NB, Peter L, Tostanoski LH, Yu J, Maliga Z, Nekorchuk M, Busman-Sahay K, Terry M, Wrijil LM, Ducat S, Martinez DR, Atyeo C, Fischinger S, Burke JS, Slein MD, Pessaint L, Van Ry A, Greenhouse J, Taylor T, Blade K, Cook A, Finneyfrock B, Brown R, Teow E, Velasco J, Zahn R, Wegmann F, Abbink P, Bondzie EA, Dagotto G, Gebre MS, He X, Jacob-Dolan C, Kordana N, Li Z, Lifton MA, Mahrokhian SH, Maxfield LF, Nityanandam R, Nkolola JP, Schmidt AG, Miller AD, Baric RS, Alter G, Sorger PK, Estes JD, Andersen H, Lewis MG, Barouch DH
A bacterial biosynthetic pathway for methylated furan fatty acids.
1. J Biol Chem - published May 2, 2020
2. Lemke RAS, Olson SM, Morse K, Karlen SD, Higbee A, Beebe ET, Ralph J, Coon JJ, Fox BG, Donohue TJ
Ion transport and regulation in a synaptic vesicle glutamate transporter.
1. Science - published May 2, 2020
2. Li F, Eriksen J, Finer-Moore J, Chang R, Nguyen P, Bowen A, Myasnikov A, Yu Z, Bulkley D, Cheng Y, Edwards RH, Stroud RM
Characterization of Warfarin Inhibition Kinetics Requires Stabilization of Intramembrane Vitamin K Epoxide Reductases.
1. J Mol Biol - published May 2, 2020
2. Li S, Liu S, Yang Y, Li W
Optical Gap Biomarker in Cone-Dominant Retinal Dystrophy.
1. Am J Ophthalmol - published May 2, 2020
2. Oh JK, Ryu J, Lima de Carvalho JR Jr, Levi SR, Lee W, Tsamis E, Greenstein VC, Mahajan VB, Allikmets R, Tsang SH
Fragment screening targeting Ebola virus nucleoprotein C-terminal domain identifies lead candidates.
1. Antiviral Res - published May 2, 2020
2. Aceti DJ, Ahmed H, Westler WM, Wu C, Dashti H, Tonelli M, Eghbalnia H, Amarasinghe GK, Markley JL
Conformational dynamics from ambiguous zinc coordination in the RanBP2-type zinc finger of RBM5.
1. J Mol Biol - published May 2, 2020
2. Soni K, Martínez-Lumbreras S, Sattler M
Professional development outcomes associated with interdisciplinary research: An integrative review.
1. Nurs Outlook - published May 2, 2020
2. Bruzzese JM, Usseglio J, Goldberg J, Begg MD, Larson EL
Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures.
1. Nat Commun - published May 2, 2020
2. Wang M, Li R, Shu B, Jing X, Ye HQ, Gong P
Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs.
1. Nat Med - published May 2, 2020
2. Murugan R, Scally SW, Costa G, Mustafa G, Thai E, Decker T, Bosch A, Prieto K, Levashina EA, Julien JP, Wardemann H
Visualizing the functional 3D shape and topography of long noncoding RNAs by single-particle atomic force microscopy and in-solution hydrodynamic techniques.
1. Nat Protoc - published May 2, 2020
2. Uroda T, Chillón I, Annibale P, Teulon JM, Pessey O, Karuppasamy M, Pellequer JL, Marcia M
The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site.
1. mBio - published May 2, 2020
2. Prévost J, Tolbert WD, Medjahed H, Sherburn RT, Madani N, Zoubchenok D, Gendron-Lepage G, Gaffney AE, Grenier MC, Kirk S, Vergara N, Han C, Mann BT, Chénine AL, Ahmed A, Chaiken I, Kirchhoff F, Hahn BH, Haim H, Abrams CF, Smith AB 3rd, Sodroski J, Pazgier M, Finzi A
Molecular Insight into TdfH-Mediated Zinc Piracy from Human Calprotectin by Neisseria gonorrhoeae.
1. mBio - published May 2, 2020
2. Kammerman MT, Bera A, Wu R, Harrison SA, Maxwell CN, Lundquist K, Noinaj N, Chazin WJ, Cornelissen CN
The architecture of EMC reveals a path for membrane protein insertion.
1. Elife - published May 2, 2020
2. O'Donnell JP, Phillips BP, Yagita Y, Juszkiewicz S, Wagner A, Malinverni D, Keenan RJ, Miller EA, Hegde RS
Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses.
1. Elife - published May 2, 2020
2. Wang L, Johnson ZL, Wasserman MR, Levring J, Chen J, Liu S
USP37 promotes deubiquitination of HIF2α in kidney cancer.
1. Proc Natl Acad Sci U S A - published May 2, 2020
2. Hong K, Hu L, Liu X, Simon JM, Ptacek TS, Zheng X, Liao C, Baldwin AS, Zhang Q
Electromechanical coupling in the hyperpolarization-activated K+ channel KAT1.
1. Nature - published May 2, 2020
2. Clark MD, Contreras GF, Shen R, Perozo E
Vulnerabilities in coronavirus glycan shields despite extensive glycosylation.
1. Nat Commun - published May 2, 2020
2. Watanabe Y, Berndsen ZT, Raghwani J, Seabright GE, Allen JD, Pybus OG, McLellan JS, Wilson IA, Bowden TA, Ward AB, Crispin M
A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity.
1. Science - published May 2, 2020
2. Meeske AJ, Jia N, Cassel AK, Kozlova A, Liao J, Wiedmann M, Patel DJ, Marraffini LA
Structure and mechanism of a unique diiron center in mammalian stearoyl-CoA desaturase.
1. J Mol Biol - published May 2, 2020
2. Shen J, Wu G, Tsai AL, Zhou M
Anisotropic ESCRT-III architecture governs helical membrane tube formation.
1. Nat Commun - published May 2, 2020
2. Moser von Filseck J, Barberi L, Talledge N, Johnson IE, Frost A, Lenz M, Roux A
Karyopherins and condensates.
1. Curr Opin Cell Biol - published May 2, 2020
2. Springhower CE, Rosen MK, Chook YM
Pandemic Preparedness: Developing Vaccines and Therapeutic Antibodies For COVID-19.
1. Cell - published May 2, 2020
2. Sempowski GD, Saunders KO, Acharya P, Wiehe KJ, Haynes BF
Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals.
1. bioRxiv - published May 2, 2020
2. Robbiani DF, Gaebler C, Muecksch F, Lorenzi JCC, Wang Z, Cho A, Agudelo M, Barnes CO, Gazumyan A, Finkin S, Hagglof T, Oliveira TY, Viant C, Hurley A, Hoffmann HH, Millard KG, Kost RG, Cipolla M, Gordon K, Bianchini F, Chen ST, Ramos V, Patel R, Dizon J, Shimeliovich I, Mendoza P, Hartweger H, Nogueira L, Pack M, Horowitz J, Schmidt F, Weisblum Y, Michailidis E, Ashbrook AW, Waltari E, Pak JE, Huey-Tubman KE, Koranda N, Hoffman PR, West AP Jr, Rice CM, Hatziioannou T, Bjorkman PJ, Bieniasz PD, Caskey M, Nussenzweig MC
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.
1. Cell - published May 2, 2020
2. Wang Q, Wu J, Wang H, Gao Y, Liu Q, Mu A, Ji W, Yan L, Zhu Y, Zhu C, Fang X, Yang X, Huang Y, Gao H, Liu F, Ge J, Sun Q, Yang X, Xu W, Liu Z, Yang H, Lou Z, Jiang B, Guddat LW, Gong P, Rao Z
Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies.
1. bioRxiv - published May 2, 2020
2. Barnes CO, West AP Jr, Huey-Tubman KE, Hoffmann MAG, Sharaf NG, Hoffman PR, Koranda N, Gristick HB, Gaebler C, Muecksch F, Cetrulo Lorenzi JC, Finkin S, Hagglof T, Hurley A, Millard KG, Weisblum Y, Schmidt F, Hatziioannou T, Bieniasz PD, Caskey M, Robbiani DF, Nussenzweig MC, Bjorkman PJ
Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2.
1. SSRN - published May 2, 2020
2. Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, Ustav M, Sidhu S, Virgin HW, Wang D, Ding S, Corti D, Theel ES, Fremont DH, Diamond MS, Whelan SPJ
Molecular Size Analysis of Recombinant Importin-histone Complexes Using Analytical Ultracentrifugation.
1. Bio Protoc - published May 2, 2020
2. Padavannil A, Brautigam CA, Chook YM
Identification of ALDH1A3 as a Viable Therapeutic Target in Breast Cancer Metastasis-Initiating Cells.
1. Mol Cancer Ther - published May 1, 2020
2. Yamashita D, Minata M, Ibrahim AN, Yamaguchi S, Coviello V, Bernstock JD, Harada S, Cerione RA, Tannous BA, La Motta C, Nakano I
A Legionella effector kinase is activated by host inositol hexakisphosphate.
1. J Biol Chem - published May 1, 2020
2. Sreelatha A, Nolan C, Park BC, Pawłowski K, Tomchick DR, Tagliabracci VS
Structural basis for gating mechanism of Pannexin 1 channel.
1. Cell Res - published May 1, 2020
2. Mou L, Ke M, Song M, Shan Y, Xiao Q, Liu Q, Li J, Sun K, Pu L, Guo L, Geng J, Wu J, Deng D
DIP/Dpr interactions and the evolutionary design of specificity in protein families.
1. Nat Commun - published May 1, 2020
2. Sergeeva AP, Katsamba PS, Cosmanescu F, Brewer JJ, Ahlsen G, Mannepalli S, Shapiro L, Honig B
Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism.
1. Nat Commun - published May 1, 2020
2. Li J, Xie Y, Cornelius S, Jiang X, Sando R, Kordon SP, Pan M, Leon K, Südhof TC, Zhao M, Araç D
19F NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2.
1. J Biol Chem - published May 1, 2020
2. Ruben EA, Gandhi PS, Chen Z, Koester SK, DeKoster GT, Frieden C, Di Cera E
Structure-Guided Engineering of the Homodimeric Mango-IV Fluorescence Turn-on Aptamer Yields an RNA FRET Pair.
1. Structure - published May 1, 2020
2. Trachman RJ 3rd, Cojocaru R, Wu D, Piszczek G, Ryckelynck M, Unrau PJ, Ferré-D'Amaré AR
Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein.
1. PLoS Pathog - published May 1, 2020
2. Joshi VR, Newman RM, Pack ML, Power KA, Munro JB, Okawa K, Madani N, Sodroski JG, Schmidt AG, Allen TM
Crystal structures of the sheeppoxvirus encoded inhibitor of apoptosis SPPV14 bound to Hrk and Bax BH3 peptides.
1. FEBS Lett - published May 1, 2020
2. Suraweera CD, Burton DR, Hinds MG, Kvansakul M
The Synthesis and Anti-tumour Properties of Poly Ethoxy Ethyl Glycinamide (PEE-G) Scaffolds with Multiple PD-1 Peptides Attached.
1. ChemMedChem - published May 1, 2020
2. Shrestha R, Petley EV, Farrand KJ, Jamieson SA, Jiao W, Teesdale-Spittle PH, Hermans IF, Mace PD, Rendle PM
A combinatorial view of old and new RNA polymerase II modifications.
1. Transcription - published May 1, 2020
2. Lyons DE, McMahon S, Ott M
S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression.
1. Cell Rep - published May 1, 2020
2. Yildirim O, Izgu EC, Damle M, Chalei V, Ji F, Sadreyev RI, Szostak JW, Kingston RE
Identification of Dengue Virus Serotype 3 Specific Antigenic Sites Targeted by Neutralizing Human Antibodies.
1. Cell Host Microbe - published May 1, 2020
2. Young E, Carnahan RH, Andrade DV, Kose N, Nargi RS, Fritch EJ, Munt JE, Doyle MP, White L, Baric TJ, Stoops M, DeSilva A, Tse LV, Martinez DR, Zhu D, Metz S, Wong MP, Espinosa DA, Montoya M, Biering SB, Sukulpolvi-Petty S, Kuan G, Balmaseda A, Diamond MS, Harris E, Crowe JE Jr, Baric RS
Chloroplast Sec14-like 1 (CPSFL1) is essential for normal chloroplast development and affects carotenoid accumulation in Chlamydomonas.
1. Proc Natl Acad Sci U S A - published May 1, 2020
2. García-Cerdán JG, Schmid EM, Takeuchi T, McRae I, McDonald KL, Yordduangjun N, Hassan AM, Grob P, Xu CS, Hess HF, Fletcher DA, Nogales E, Niyogi KK
Structure-Activity Relationship Study Reveals the Molecular Basis for Specific Sensing of Hydrophobic Amino Acids by the Campylobacter jejuni Chemoreceptor Tlp3.
1. Biomolecules - published May 1, 2020
2. Khan MF, Machuca MA, Rahman MM, Koç C, Norton RS, Smith BJ, Roujeinikova A
Physician Assistant's Knowledge and Confidence Regarding Prescribing Pre-Exposure Prophylaxis for HIV Prevention.
1. Sex Transm Dis - published May 1, 2020
2. Bunting SR, Miller KW, Chappell R, Goldstein RH, DeJean O
Escherichia coli YcaQ is a DNA glycosylase that unhooks DNA interstrand crosslinks.
1. Nucleic Acids Res - published May 1, 2020
2. Bradley NP, Washburn LA, Christov PP, Watanabe CMH, Eichman BF
De novo protein design enables the precise induction of RSV-neutralizing antibodies.
1. Science - published May 1, 2020
2. Sesterhenn F, Yang C, Bonet J, Cramer JT, Wen X, Wang Y, Chiang CI, Abriata LA, Kucharska I, Castoro G, Vollers SS, Galloux M, Dheilly E, Rosset S, Corthésy P, Georgeon S, Villard M, Richard CA, Descamps D, Delgado T, Oricchio E, Rameix-Welti MA, Más V, Ervin S, Eléouët JF, Riffault S, Bates JT, Julien JP, Li Y, Jardetzky T, Krey T, Correia BE
β-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19.
1. Circulation - published May 1, 2020
2. Manglik A, Wingler LM, Rockman HA, Lefkowitz RJ
Optimizing the α1B-adrenergic receptor for solution NMR studies.
1. Biochim Biophys Acta Biomembr - published May 1, 2020
2. Schuster M, Deluigi M, Pantić M, Vacca S, Baumann C, Scott DJ, Plückthun A, Zerbe O
Structural insight into tanapoxvirus mediated inhibition of apoptosis.
1. FEBS J - published May 1, 2020
2. Suraweera CD, Anasir MI, Chugh S, Javorsky A, Impey RE, Hasan Zadeh M, Soares da Costa TP, Hinds MG, Kvansakul M
Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema.
1. Cell - published May 1, 2020
2. Kitchen P, Salman MM, Halsey AM, Clarke-Bland C, MacDonald JA, Ishida H, Vogel HJ, Almutiri S, Logan A, Kreida S, Al-Jubair T, Winkel Missel J, Gourdon P, Törnroth-Horsefield S, Conner MT, Ahmed Z, Conner AC, Bill RM
Mutation severity spectrum of rare alleles in the human genome is predictive of disease type.
1. PLoS Comput Biol - published May 1, 2020
2. Pei J, Kinch LN, Otwinowski Z, Grishin NV
GemSpot: A Pipeline for Robust Modeling of Ligands into Cryo-EM Maps.
1. Structure - published May 1, 2020
2. Robertson MJ, van Zundert GCP, Borrelli K, Skiniotis G
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response.
1. Nat Commun - published May 1, 2020
2. Dufey E, Bravo-San Pedro JM, Eggers C, González-Quiroz M, Urra H, Sagredo AI, Sepulveda D, Pihán P, Carreras-Sureda A, Hazari Y, Sagredo EA, Gutierrez D, Valls C, Papaioannou A, Acosta-Alvear D, Campos G, Domingos PM, Pedeux R, Chevet E, Alvarez A, Godoy P, Walter P, Glavic A, Kroemer G, Hetz C
Publisher Correction: A human monoclonal antibody blocking SARS-CoV-2 infection.
1. Nat Commun - published May 1, 2020
2. Wang C, Li W, Drabek D, Okba NMA, van Haperen R, Osterhaus ADME, van Kuppeveld FJM, Haagmans BL, Grosveld F, Bosch BJ
Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation.
1. Nat Commun - published May 1, 2020
2. Bamford NC, Le Mauff F, Van Loon JC, Ostapska H, Snarr BD, Zhang Y, Kitova EN, Klassen JS, Codée JDC, Sheppard DC, Howell PL
Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane.
1. Proc Natl Acad Sci U S A - published May 1, 2020
2. Fang Z, Lee KY, Huo KG, Gasmi-Seabrook G, Zheng L, Moghal N, Tsao MS, Ikura M, Marshall CB
Tetracycline-inactivating enzymes from environmental, human commensal, and pathogenic bacteria cause broad-spectrum tetracycline resistance.
1. Commun Biol - published May 1, 2020
2. Gasparrini AJ, Markley JL, Kumar H, Wang B, Fang L, Irum S, Symister CT, Wallace M, Burnham CD, Andleeb S, Tolia NH, Wencewicz TA, Dantas G
The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility.
1. Proc Natl Acad Sci U S A - published May 1, 2020
2. Kim J, Grotegut CA, Wisler JW, Mao L, Rosenberg PB, Rockman HA, Lefkowitz RJ
Development of CDK2 and CDK5 Dual Degrader TMX-2172.
1. Angew Chem Int Ed Engl - published May 1, 2020
2. Gray NS, Teng M, Jiang J, He Z, Kwiatkowski NP, Donovan KA, Mills CE, Victor C, Hatcher JM, Fischer ES, Sorger PK, Zhang T
Vinpocetine reduces cisplatin-induced acute kidney injury through inhibition of NF-κB pathway and activation of Nrf2/ARE pathway in rats.
1. Int Urol Nephrol - published May 1, 2020
2. Song W, Yin W, Ding L, Gao Y, Xu J, Yang Y, He X, Gong P, Wei L, Chen W, Zhang J
Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from Mycobacterium tuberculosis.
1. ACS Chem Biol - published May 1, 2020
2. Punetha A, Ngo HX, Holbrook SYL, Green KD, Willby MJ, Bonnett SA, Krieger K, Dennis EK, Posey JE, Parish T, Tsodikov OV, Garneau-Tsodikova S
The Conformational States of the HIV-1 Envelope Glycoproteins.
1. Trends Microbiol - published May 1, 2020
2. Wang Q, Finzi A, Sodroski J
In Response to Regarding: Apoptosis Signaling Molecules as Treatment Targets in Head and Neck Squamous Carcinoma.
1. Laryngoscope - published May 1, 2020
2. Ow TJ, Thomas C, Fulcher CD, Chen J, López A, Reyna DE, Prystowsky MB, Smith RV, Schiff BA, Rosenblatt G, Belbin TJ, Harris TM, Childs GC, Kawachi N, Schlecht NF, Gavathiotis E
Author Correction: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.
1. Nat Commun - published May 1, 2020
2. Färkkilä A, Gulhan DC, Casado J, Jacobson CA, Nguyen H, Kochupurakkal B, Maliga Z, Yapp C, Chen YA, Schapiro D, Zhou Y, Graham JR, Dezube BJ, Munster P, Santagata S, Garcia E, Rodig S, Lako A, Chowdhury D, Shapiro GI, Matulonis UA, Park PJ, Hautaniemi S, Sorger PK, Swisher EM, D'Andrea AD, Konstantinopoulos PA
RiboToolkit: an integrated platform for analysis and annotation of ribosome profiling data to decode mRNA translation at codon resolution.
1. Nucleic Acids Res - published May 1, 2020
2. Liu Q, Shvarts T, Sliz P, Gregory RI
mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding.
1. Elife - published May 1, 2020
2. Bao C, Loerch S, Ling C, Korostelev AA, Grigorieff N, Ermolenko DN
A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission.
1. Nat Struct Mol Biol - published May 1, 2020
2. Flower TG, Takahashi Y, Hudait A, Rose K, Tjahjono N, Pak AJ, Yokom AL, Liang X, Wang HG, Bouamr F, Voth GA, Hurley JH
Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.
1. Cell Mol Neurobiol - published May 1, 2020
2. Bao C, Bajrami B, Marcotte DJ, Chodaparambil JV, Kerns HM, Henderson J, Wei R, Gao B, Dillon GM
Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme.
1. Nature - published May 1, 2020
2. Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese RV Jr
Integrated Structural Modeling of Full-Length LRH-1 Reveals Inter-domain Interactions Contribute to Receptor Structure and Function.
1. Structure - published May 1, 2020
2. Seacrist CD, Kuenze G, Hoffmann RM, Moeller BE, Burke JE, Meiler J, Blind RD
Structure and mechanism of human diacylglycerol O-acyltransferase 1.
1. Nature - published May 1, 2020
2. Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, Hu L, Prasad BVV, Laganowsky A, Yan N, Zhou M
Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel.
1. Cell Chem Biol - published May 1, 2020
2. Pantouris G, Khurana L, Ma A, Skeens E, Reiss K, Batista VS, Lisi GP, Lolis EJ
High-resolution cryo-EM reconstructions in the presence of substantial aberrations.
1. IUCrJ - published May 1, 2020
2. Bromberg R, Guo Y, Borek D, Otwinowski Z
Structure-Guided Identification of DNMT3B Inhibitors.
1. ACS Med Chem Lett - published May 1, 2020
2. Newton AS, Faver JC, Micevic G, Muthusamy V, Kudalkar SN, Bertoletti N, Anderson KS, Bosenberg MW, Jorgensen WL
HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis.
1. Mol Cell - published May 1, 2020
2. Bai G, Kermi C, Stoy H, Schiltz CJ, Bacal J, Zaino AM, Hadden MK, Eichman BF, Lopes M, Cimprich KA
A Single Shot Pre-fusion-Stabilized Bovine RSV F Vaccine is Safe and Effective in Newborn Calves with Maternally Derived Antibodies.
1. Vaccines (Basel) - published May 1, 2020
2. Riffault S, Hägglund S, Guzman E, Näslund K, Jouneau L, Dubuquoy C, Pietralunga V, Laubreton D, Boulesteix O, Gauthier D, Remot A, Boukaridi A, Falk A, Shevchenko G, Lind SB, Vargmar K, Zhang B, Kwong PD, Rodriguez MJ, Duran MG, Schwartz-Cornil I, Eléouët JF, Taylor G, Valarcher JF
A Primase-Induced Conformational Switch Controls the Stability of the Bacterial Replisome.
1. Mol Cell - published May 1, 2020
2. Monachino E, Jergic S, Lewis JS, Xu ZQ, Lo ATY, O'Shea VL, Berger JM, Dixon NE, van Oijen AM
Test performance evaluation of SARS-CoV-2 serological assays.
1. medRxiv - published May 1, 2020
2. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD 2nd, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk R, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A
Controlling the SARS-CoV-2 Spike Glycoprotein Conformation.
1. bioRxiv - published May 1, 2020
2. Henderson R, Edwards RJ, Mansouri K, Janowska K, Stalls V, Gobeil S, Kopp M, Hsu A, Borgnia M, Parks R, Haynes BF, Acharya P
Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein.
1. bioRxiv - published May 1, 2020
2. Wec AZ, Wrapp D, Herbert AS, Maurer D, Haslwanter D, Sakharkar M, Jangra RK, Dieterle ME, Lilov A, Huang D, Tse LV, Johnson NV, Hsieh CL, Wang N, Nett JH, Champney E, Burnina I, Brown M, Lin S, Sinclair M, Johnson C, Pudi S, Bortz R 3rd, Wirchnianski AS, Laudermilch E, Florez C, Fels JM, O'Brien CM, Graham BS, Nemazee D, Burton DR, Baric RS, Voss JE, Chandran K, Dye JM, McLellan JS, Walker LM
Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation.
1. Nat Metab - published May 1, 2020
2. Fu A, Alvarez-Perez JC, Avizonis D, Kin T, Ficarro SB, Choi DW, Karakose E, Badur MG, Evans L, Rosselot C, Bridon G, Bird GH, Seo HS, Dhe-Paganon S, Kamphorst JJ, Stewart AF, James Shapiro AM, Marto JA, Walensky LD, Jones RG, Garcia-Ocana A, Danial NN
Attenuated diphtheria toxin mediates siRNA delivery.
1. Sci Adv - published May 1, 2020
2. Arnold AE, Smith LJ, Beilhartz GL, Bahlmann LC, Jameson E, Melnyk RA, Shoichet MS
c-Rel Is a Myeloid Checkpoint for Cancer Immunotherapy.
1. Nat Cancer - published May 1, 2020
2. Li T, Li X, Zamani A, Wang W, Lee CN, Li M, Luo G, Eiler E, Sun H, Ghosh S, Jin J, Murali R, Ruan Q, Shi W, Chen YH