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118 Member Publications for April 2020

Specificity in PDZ-peptide interaction networks: Computational analysis and review.
1. J Struct Biol X - published April 15, 2020
2. Amacher JF, Brooks L, Hampton TH, Madden DR
Eliminating effects of particle adsorption to the air/water interface in single-particle cryo-electron microscopy: Bacterial RNA polymerase and CHAPSO.
1. J Struct Biol X - published April 15, 2020
2. Chen J, Noble AJ, Kang JY, Darst SA
Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design.
1. J Med Chem - published April 9, 2020
2. Chacón Simon S, Wang F, Thomas LR, Phan J, Zhao B, Olejniczak ET, Macdonald JD, Shaw JG, Schlund C, Payne W, Creighton J, Stauffer SR, Waterson AG, Tansey WP, Fesik SW
Membrane mediated toppling mechanism of the folate energy coupling factor transporter.
1. Nat Commun - published April 9, 2020
2. Faustino I, Abdizadeh H, Souza PCT, Jeucken A, Stanek WK, Guskov A, Slotboom DJ, Marrink SJ
Differential kinase activity of ACVR1 G328V and R206H mutations with implications to possible TβRI cross-talk in diffuse intrinsic pontine glioma.
1. Sci Rep - published April 9, 2020
2. Cao H, Jin M, Gao M, Zhou H, Tao YJ, Skolnick J
Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors.
1. ACS Med Chem Lett - published April 9, 2020
2. Xin Z, Himmelbauer MK, Jones JH, Enyedy I, Gilfillan R, Hesson T, King K, Marcotte DJ, Murugan P, Santoro JC, Gonzalez-Lopez de Turiso F
The promise of selective MET inhibitors in non-small cell lung cancer with MET exon 14 skipping.
1. Cancer Treat Rev - published April 9, 2020
2. Salgia R, Sattler M, Scheele J, Stroh C, Felip E
Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses.
1. bioRxiv - published April 9, 2020
2. Gussow AB, Auslander N, Faure G, Wolf YI, Zhang F, Koonin EV
Introducing the CSP Analyzer: A novel Machine Learning-based application for automated analysis of two-dimensional NMR spectra in NMR fragment-based screening.
1. Comput Struct Biotechnol J - published April 8, 2020
2. Fino R, Byrne R, Softley CA, Sattler M, Schneider G, Popowicz GM
Quarantine alone or in combination with other public health measures to control COVID-19: a rapid review.
1. Cochrane Database Syst Rev - published April 8, 2020
2. Nussbaumer-Streit B, Mayr V, Dobrescu AI, Chapman A, Persad E, Klerings I, Wagner G, Siebert U, Christof C, Zachariah C, Gartlehner G
Oxadiazole-Containing Macrocyclic Peptides Potentiate Azole Activity against Pathogenic Candida Species.
1. mSphere - published April 8, 2020
2. Revie NM, Robbins N, Whitesell L, Frost JR, Appavoo SD, Yudin AK, Cowen LE
Generation of synthetic nanobodies against delicate proteins.
1. Nat Protoc - published April 8, 2020
2. Zimmermann I, Egloff P, Hutter CAJ, Kuhn BT, Bräuer P, Newstead S, Dawson RJP, Geertsma ER, Seeger MA
Microfluidic Electroporation Coupling Pulses of Nanoseconds and Milliseconds to Facilitate Rapid Uptake and Enhanced Expression of DNA in Cell Therapy.
1. Sci Rep - published April 8, 2020
2. Chang AY, Liu X, Tian H, Hua L, Yang Z, Wang S
High-Throughput Cryo-EM Enabled by User-Free Preprocessing Routines.
1. Structure - published April 8, 2020
2. Li Y, Cash JN, Tesmer JJG, Cianfrocco MA
Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies.
1. Cell Host Microbe - published April 8, 2020
2. Ilinykh PA, Huang K, Santos RI, Gilchuk P, Gunn BM, Karim MM, Liang J, Fouch ME, Davidson E, Parekh DV, Kimble JB, Pietzsch CA, Meyer M, Kuzmina NA, Zeitlin L, Saphire EO, Alter G, Crowe JE Jr, Bukreyev A
Bayesian inference of chromatin structure ensembles from population-averaged contact data.
1. Proc Natl Acad Sci U S A - published April 7, 2020
2. Carstens S, Nilges M, Habeck M
Synthesis, radiolabelling and initial biological characterisation of 18F-labelled xanthine derivatives for PET imaging of Eph receptors.
1. Org Biomol Chem - published April 7, 2020
2. Pretze M, Neuber C, Kinski E, Belter B, Köckerling M, Caflisch A, Steinbach J, Pietzsch J, Mamat C
IRE1α disruption in triple-negative breast cancer cooperates with anti-angiogenic therapy by reversing ER stress adaptation and remodeling the tumor microenvironment.
1. Cancer Res - published April 7, 2020
2. Harnoss JM, Le Thomas A, Reichelt M, Guttman O, Wu TD, Marsters SA, Shemorry A, Lawrence DA, Kan D, Segal E, Merchant M, Totpal K, Crocker LM, Mesh K, Dohse M, Solon M, Modrusan Z, Rudolph J, Koeppen H, Walter P, Ashkenazi A
Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition.
1. Cell Rep - published April 7, 2020
2. Gorman J, Chuang GY, Lai YT, Shen CH, Boyington JC, Druz A, Geng H, Louder MK, McKee K, Rawi R, Verardi R, Yang Y, Zhang B, Doria-Rose NA, Lin B, Moore PL, Morris L, Shapiro L, Mascola JR, Kwong PD
X Caps the Phosphate for Phospho-Rab GTPase Recognition in Ciliogenesis and Parkinson's Disease.
1. Structure - published April 7, 2020
2. Struck MW, Pazour GJ, Lambright DG
Progress in nicotinic receptor structural biology.
1. Neuropharmacology - published April 7, 2020
2. Gharpure A, Noviello CM, Hibbs RE
Correction: The potent and selective cyclin-dependent kinases 4 and 6 inhibitor ribociclib (LEE011) is a versatile combination partner in preclinical cancer models.
1. Oncotarget - published April 7, 2020
2. Kim S, Tiedt R, Loo A, Horn T, Delach S, Kovats S, Haas K, Engstler BS, Cao A, Pinzon-Ortiz M, Mulford I, Acker MG, Chopra R, Brain C, Tomaso ED, Sellers WR, Caponigro G
Selective and Wash-Resistant Fluorescent Dihydrocodeinone Derivatives Allow Single-Molecule Imaging of μ-Opioid Receptor Dimerization.
1. Angew Chem Int Ed Engl - published April 6, 2020
2. Gentzsch C, Seier K, Drakopoulos A, Jobin ML, Lanoiselée Y, Koszegi Z, Maurel D, Sounier R, Hübner H, Gmeiner P, Granier S, Calebiro D, Decker M
Discovery of a selective inhibitor of doublecortin like kinase 1.
1. Nat Chem Biol - published April 6, 2020
2. Ferguson FM, Nabet B, Raghavan S, Liu Y, Leggett AL, Kuljanin M, Kalekar RL, Yang A, He S, Wang J, Ng RWS, Sulahian R, Li L, Poulin EJ, Huang L, Koren J, Dieguez-Martinez N, Espinosa S, Zeng Z, Corona CR, Vasta JD, Ohi R, Sim T, Kim ND, Harshbarger W, Lizcano JM, Robers MB, Muthaswamy S, Lin CY, Look AT, Haigis KM, Mancias JD, Wolpin BM, Aguirre AJ, Hahn WC, Westover KD, Gray NS
Structure, dynamics, and function of the evolutionarily changing biliverdin reductase B family.
1. J Biochem - published April 4, 2020
2. Duff MR, Redzic JS, Ryan LP, Paukovich N, Zhao R, Nix JC, Pitts TM, Agarwal P, Eisenmesser EZ
Sequencing and structure probing of long RNAs using MarathonRT: a next-generation reverse transcriptase.
1. J Mol Biol - published April 4, 2020
2. Guo LT, Adams RL, Wan H, Huston NC, Potapova O, Olson S, Gallardo CM, Graveley BR, Torbett BE, Pyle AM
The two splice variant forms of Cdc42 exert distinct and essential functions in neurogenesis.
1. J Biol Chem - published April 3, 2020
2. Endo M, Druso JE, Cerione RA
Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids.
1. J Biol Chem - published April 3, 2020
2. Wiechmann S, Maisonneuve P, Grebbin BM, Hoffmeister M, Kaulich M, Clevers H, Rajalingam K, Kurinov I, Farin HF, Sicheri F, Ernst A
Structural basis for allosteric PARP-1 retention on DNA breaks.
1. Science - published April 3, 2020
2. Zandarashvili L, Langelier MF, Velagapudi UK, Hancock MA, Steffen JD, Billur R, Hannan ZM, Wicks AJ, Krastev DB, Pettitt SJ, Lord CJ, Talele TT, Pascal JM, Black BE
The NFκB pathway promotes tamoxifen tolerance and disease recurrence in estrogen receptor positive breast cancers.
1. Mol Cancer Res - published April 3, 2020
2. Kastrati I, Joosten SEP, Semina SE, Alejo LH, Brovkovych SD, Stender JD, Horlings HM, Kok M, Alarid ET, Greene GL, Linn SC, Zwart W, Frasor J
Monitoring protease activity in biological tissues using antibody prodrugs as sensing probes.
1. Sci Rep - published April 3, 2020
2. Vasiljeva O, Menendez E, Nguyen M, Craik CS, Michael Kavanaugh W
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
1. Nature - published April 3, 2020
2. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ
The SrrAB two-component system regulates Staphylococcus aureus pathogenicity through redox sensitive cysteines.
1. Proc Natl Acad Sci U S A - published April 3, 2020
2. Tiwari N, López-Redondo M, Miguel-Romero L, Kulhankova K, Cahill MP, Tran PM, Kinney KJ, Kilgore SH, Al-Tameemi H, Herfst CA, Tuffs SW, Kirby JR, Boyd JM, McCormick JK, Salgado-Pabón W, Marina A, Schlievert PM, Fuentes EJ
Adhesion Protein Structure, Molecular Affinities, and Principles of Cell-Cell Recognition.
1. Cell - published April 3, 2020
2. Honig B, Shapiro L
Arresting Developments in Biased Signaling.
1. Trends Pharmacol Sci - published April 3, 2020
2. Yoo SM, Bhardwaj A, Benovic JL
Bacterial flagellar motor PL-ring disassembly subcomplexes are widespread and ancient.
1. Proc Natl Acad Sci U S A - published April 2, 2020
2. Kaplan M, Sweredoski MJ, Rodrigues JPGLM, Tocheva EI, Chang YW, Ortega DR, Beeby M, Jensen GJ
CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors.
1. Cell - published April 2, 2020
2. Wang D, Zhang F, Gao G
Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance.
1. Nat Commun - published April 2, 2020
2. Huoh YS, Wu B, Park S, Yang D, Bansal K, Greenwald E, Wong WP, Mathis D, Hur S
Structure-Guided Molecular Grafting of a Complex Broadly Neutralizing Viral Epitope.
1. ACS Infect Dis - published April 2, 2020
2. Bajic G, Maron MJ, Caradonna TM, Tian M, Mermelstein A, Fera D, Kelsoe G, Kuraoka M, Schmidt AG
Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins.
1. Neuron - published April 2, 2020
2. Rahman MM, Teng J, Worrell BT, Noviello CM, Lee M, Karlin A, Stowell MHB, Hibbs RE
Structural and functional characterization of the severe fever with thrombocytopenia syndrome virus L protein.
1. Nucleic Acids Res - published April 2, 2020
2. Vogel D, Thorkelsson SR, Quemin ERJ, Meier K, Kouba T, Gogrefe N, Busch C, Reindl S, Günther S, Cusack S, Grünewald K, Rosenthal M
Exosomes as Sentinels against Bacterial Pathogens.
1. Dev Cell - published April 2, 2020
2. Panizza E, Cerione RA, Antonyak MA
Phase-plate cryo-EM structure of the Widom 601 CENP-A nucleosome core particle reveals differential flexibility of the DNA ends.
1. Nucleic Acids Res - published April 2, 2020
2. Boopathi R, Danev R, Khoshouei M, Kale S, Nahata S, Ramos L, Angelov D, Dimitrov S, Hamiche A, Petosa C, Bednar J
The Positively Charged Active Site of the Bacterial Toxin RelE Causes a Large Shift in the General Base pKa.
1. Biochemistry - published April 2, 2020
2. Hiller DA, Dunican BF, Nallur S, Li NS, Piccirilli JA, Strobel SA
Same structure, different mechanisms?
1. Elife - published April 2, 2020
2. Tsai FT, Hill CP
Structural basis for Zika envelope domain III recognition by a germline version of a recurrent neutralizing antibody.
1. Proc Natl Acad Sci U S A - published April 2, 2020
2. Esswein SR, Gristick HB, Jurado A, Peace A, Keeffe JR, Lee YE, Voll AV, Saeed M, Nussenzweig MC, Rice CM, Robbiani DF, MacDonald MR, Bjorkman PJ
The post-lockdown period should be used to acquire effective therapies for future resurgence in SARS-Cov-2 infections.
1. N Z Med J - published April 2, 2020
2. Krause KL, Furneaux R, Benjes P, Brimble M, Davidson T, Denny W, Harris L, Hinkley S, Tyler P, Ussher JE, Ward V
Oligomerization of the vesicular stomatitis virus phosphoprotein is dispensable for mRNA synthesis but facilitates RNA replication.
1. J Virol - published April 2, 2020
2. Bloyet LM, Morin B, Brusic V, Gardner E, Ross RA, Vadakkan T, Kirchhausen T, Whelan SPJ
Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex.
1. Science - published April 2, 2020
2. Wu X, Siggel M, Ovchinnikov S, Mi W, Svetlov V, Nudler E, Liao M, Hummer G, Rapoport TA
O-GlcNAc regulates gene expression by controlling detained intron splicing.
1. Nucleic Acids Res - published April 2, 2020
2. Tan ZW, Fei G, Paulo JA, Bellaousov S, Martin SES, Duveau DY, Thomas CJ, Gygi SP, Boutz PL, Walker S
The integrated stress response: From mechanism to disease.
1. Science - published April 2, 2020
2. Costa-Mattioli M, Walter P
Structural and Functional Characterization of NadR from Lactococcus lactis.
1. Molecules - published April 2, 2020
2. Stetsenko A, Singh R, Jaehme M, Guskov A, Slotboom DJ
High-resolution views of lipopolysaccharide translocation driven by ABC transporters MsbA and LptB2FGC.
1. Curr Opin Struct Biol - published April 2, 2020
2. Thélot F, Orlando BJ, Li Y, Liao M
Clinico-genetic, imaging and molecular delineation of COQ8A-ataxia: a multicenter study of 59 patients.
1. Ann Neurol - published April 2, 2020
2. Traschütz A, Schirinzi T, Laugwitz L, Murray NH, Bingman CA, Reich S, Kern J, Heinzmann A, Vasco G, Bertini E, Zanni G, Durr A, Magri S, Taroni F, Malandrini A, Baets J, de Jonghe P, de Ridder W, Bereau M, Demuth S, Ganos C, Basak AN, Hanagasi H, Kurul SH, Bender B, Schöls L, Grasshoff U, Klopstock T, Horvath R, van de Warrenburg B, Burglen L, Rougeot C, Ewenczyk C, Koenig M, Santorelli FM, Anheim M, Munhoz RP, Haack T, Distelmaier F, Pagliarini DJ, Puccio H, Synofzik M
Reply to Tedeschi, et al.
1. Clin Infect Dis - published April 2, 2020
2. Hanff TC, Harhay MO, Brown TS, Cohen JB, Mohareb AM
A phase I study of panobinostat in children with relapsed and refractory hematologic malignancies.
1. Pediatr Hematol Oncol - published April 2, 2020
2. Goldberg J, Bender J, Jeha S, Sulis ML, Gardner R, Pollard J, Aquino V, Laetsch T, Winick N, Fu C, Marcus L, Sun W, Verma A, Burke M, Ho P, Manley T, Mody R, Tcheng W, Thomson B, Park J, Sposto R, Messinger Y, Hijiya N, Gaynon P, Barredo J
A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking.
1. Elife - published April 2, 2020
2. Susa KJ, Seegar TC, Blacklow SC, Kruse AC
Structure and Function of Influenza Polymerase.
1. Cold Spring Harb Perspect Med - published April 2, 2020
2. Wandzik JM, Kouba T, Cusack S
HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies.
1. Cell Rep - published April 2, 2020
2. Rantalainen K, Berndsen ZT, Antanasijevic A, Schiffner T, Zhang X, Lee WH, Torres JL, Zhang L, Irimia A, Copps J, Zhou KH, Kwon YD, Law WH, Schramm CA, Verardi R, Krebs SJ, Kwong PD, Doria-Rose NA, Wilson IA, Zwick MB, Yates JR 3rd, Schief WR, Ward AB
Phase II Trial of Hippocampal-Sparing Whole Brain Irradiation with Simultaneous Integrated Boost (HSIB-WBRT) for Metastatic Cancer.
1. Neuro Oncol - published April 2, 2020
2. Westover KD, Mendel JT, Dan T, Kumar K, Gao A, Pulipparacharuv S, Iyengar P, Nedzi L, Hannan R, Anderson J, Choe KS, Jiang W, Abdulrahman R, Rahimi A, Folkert M, Laine A, Presley C, Cullum CM, Choy H, Ahn C, Timmerman R
Tubulin Resists Degradation by Cereblon-Recruiting PROTACs.
1. Cells - published April 2, 2020
2. Gasic I, Groendyke BJ, Nowak RP, Yuan JC, Kalabathula J, Fischer ES, Gray NS, Mitchison TJ
Structural Analysis of Jumbo Coliphage phAPEC6.
1. Int J Mol Sci - published April 2, 2020
2. Wagemans J, Tsonos J, Holtappels D, Fortuna K, Hernalsteens JP, Greve H, Estrozi LF, Bacia-Verloop M, Moriscot C, Noben JP, Schoehn G, Lavigne R
Exploring the structure and dynamics of macromolecular complexes by native mass spectrometry.
1. J Proteomics - published April 2, 2020
2. Erba E, Signor L, Petosa C
Identification of a Structural Determinant for Selective Targeting of HDMX.
1. Structure - published April 2, 2020
2. Ben-Nun Y, Seo HS, Harvey EP, Hauseman ZJ, Wales TE, Newman CE, Cathcart AM, Engen JR, Dhe-Paganon S, Walensky LD
Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.
1. Cell - published April 2, 2020
2. Wrapp D, De Vlieger D, Corbett KS, Torres GM, Wang N, Van Breedam W, Roose K, van Schie L, VIB-CMB COVID-19 Response Team., Hoffmann M, Pöhlmann S, Graham BS, Callewaert N, Schepens B, Saelens X, McLellan JS
The cytotoxicity of gallium maltolate in glioblastoma cells is enhanced by metformin through combined action on mitochondrial complex 1.
1. Oncotarget - published April 2, 2020
2. Alhajala HS, Markley JL, Kim JH, Al-Gizawiy MM, Schmainda KM, Kuo JS, Chitambar CR
Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering.
1. Cell Chem Biol - published April 2, 2020
2. Harvey EP, Hauseman ZJ, Cohen DT, Rettenmaier TJ, Lee S, Huhn AJ, Wales TE, Seo HS, Luccarelli J, Newman CE, Guerra RM, Bird GH, Dhe-Paganon S, Engen JR, Wells JA, Walensky LD
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.
1. Cell - published April 2, 2020
2. Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH 2nd, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi LE, Barbry P, Leslie A, Kiem HP, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J, HCA Lung Biological Network. Electronic address: lung-network@humancellatlas.org., HCA Lung Biological Network.
Analysis of SteraMist ionized hydrogen peroxide technology in the sterilization of N95 respirators and other PPE: a quality improvement study.
1. medRxiv - published April 2, 2020
2. Cramer AK, Plana D, Yang H, Carmack MM, Tian E, Sinha MS, Krikorian D, Turner D, Mo J, Li J, Gupta R, Manning H, Bourgeois FT, Yu SH, Sorger PK, LeBoeuf NR
Solid-state NMR studies of solvent-mediated, acid-catalyzed woody biomass pre-treatment for enzymatic conversion of residual cellulose.
1. ACS Sustain Chem Eng - published April 2, 2020
2. Walker TW, Kuch N, Vander Meulen KA, Clewett CFM, Huber GW, Fox BG, Dumesic JA
Differential Inhibition of APOBEC3 DNA-Mutator Isozymes by Fluoro- and Non-Fluoro-Substituted 2'-Deoxyzebularine Embedded in Single-Stranded DNA.
1. Chembiochem - published April 1, 2020
2. Kvach MV, Barzak FM, Harjes S, Schares HAM, Kurup HM, Jones KF, Sutton L, Donahue J, D'Aquila RT, Jameson GB, Harki DA, Krause KL, Harjes E, Filichev VV
Extracellular vesicles and their roles in stem cell biology.
1. Stem Cells - published April 1, 2020
2. Hur YH, Cerione RA, Antonyak MA
Predicting partition coefficients of drug-like molecules in the SAMPL6 challenge with Drude polarizable force fields.
1. J Comput Aided Mol Des - published April 1, 2020
2. Ding Y, Xu Y, Qian C, Chen J, Zhu J, Huang H, Shi Y, Huang J
Imaging findings in Möbius-Poland syndrome.
1. Radiol Case Rep - published April 1, 2020
2. Parenti VG, Liu X, Mehta A, Malireddy R, Sutherlun LA, Pfeifer CM
Elongation Factor Tu Switch I Element is a Gate for Aminoacyl-tRNA Selection.
1. J Mol Biol - published April 1, 2020
2. Girodat D, Blanchard SC, Wieden HJ, Sanbonmatsu KY
RAD51 discrimination between single- and double-strand DNA: a matter of flexibility and enthalpy.
1. EMBO J - published April 1, 2020
2. Subramanyam S, Spies M
Receptor tyrosine kinase activation: From the ligand perspective.
1. Curr Opin Cell Biol - published April 1, 2020
2. Trenker R, Jura N
Nucleoporin Condensates Drive Nuclear Pore Complex Assembly in Oocytes.
1. Trends Biochem Sci - published April 1, 2020
2. Mobbs GW, Hoelz A
Discovery and characterization of a Gram-positive Pel polysaccharide biosynthetic gene cluster.
1. PLoS Pathog - published April 1, 2020
2. Whitfield GB, Marmont LS, Bundalovic-Torma C, Razvi E, Roach EJ, Khursigara CM, Parkinson J, Howell PL
A systematic pipeline for classifying bacterial operons reveals the evolutionary landscape of biofilm machineries.
1. PLoS Comput Biol - published April 1, 2020
2. Bundalovic-Torma C, Whitfield GB, Marmont LS, Howell PL, Parkinson J
Ferritin-Displayed GLP-1 with Improved Pharmacological Activities and Pharmacokinetics.
1. Mol Pharm - published April 1, 2020
2. Su W, Tan H, Janowski R, Zhang W, Wang P, Zhang J, Zhai H, Li J, Niessing D, Sattler M, Zou P
Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors.
1. J Med Chem - published April 1, 2020
2. Heppner DE, Günther M, Wittlinger F, Laufer SA, Eck MJ
Membrane constriction and thinning by sequential ESCRT-III polymerization.
1. Nat Struct Mol Biol - published April 1, 2020
2. Nguyen HC, Talledge N, McCullough J, Sharma A, Moss FR 3rd, Iwasa JH, Vershinin MD, Sundquist WI, Frost A
Scaling diffraction data in the DIALS software package: algorithms and new approaches for multi-crystal scaling.
1. Acta Crystallogr D Struct Biol - published April 1, 2020
2. Beilsten-Edmands J, Winter G, Gildea R, Parkhurst J, Waterman D, Evans G
DNA clamp function of the monoubiquitinated Fanconi anaemia ID complex.
1. Nature - published April 1, 2020
2. Wang R, Wang S, Dhar A, Peralta C, Pavletich NP
MAP6 is an intraluminal protein that induces neuronal microtubules to coil.
1. Sci Adv - published April 1, 2020
2. Cuveillier C, Delaroche J, Seggio M, Gory-Fauré S, Bosc C, Denarier E, Bacia M, Schoehn G, Mohrbach H, Kulić I, Andrieux A, Arnal I, Delphin C
Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells.
1. Sci Adv - published April 1, 2020
2. Carter SD, Hampton CM, Langlois R, Melero R, Farino ZJ, Calderon MJ, Li W, Wallace CT, Tran NH, Grassucci RA, Siegmund SE, Pemberton J, Morgenstern TJ, Eisenman L, Aguilar JI, Greenberg NL, Levy ES, Yi E, Mitchell WG, Rice WJ, Wigge C, Pilli J, George EW, Aslanoglou D, Courel M, Freyberg RJ, Javitch JA, Wills ZP, Area-Gomez E, Shiva S, Bartolini F, Volchuk A, Murray SA, Aridor M, Fish KN, Walter P, Balla T, Fass D, Wolf SG, Watkins SC, Carazo JM, Jensen GJ, Frank J, Freyberg Z
Halting coronavirus polymerase.
1. J Biol Chem - published April 1, 2020
2. Kirchdoerfer RN
Structure of polymerized type V pilin reveals assembly mechanism involving protease-mediated strand exchange.
1. Nat Microbiol - published April 1, 2020
2. Shibata S, Shoji M, Okada K, Matsunami H, Matthews MM, Imada K, Nakayama K, Wolf M
Quantifying the heterogeneity of macromolecular machines by mass photometry.
1. Nat Commun - published April 1, 2020
2. Sonn-Segev A, Belacic K, Bodrug T, Young G, VanderLinden RT, Schulman BA, Schimpf J, Friedrich T, Dip PV, Schwartz TU, Bauer B, Peters JM, Struwe WB, Benesch JLP, Brown NG, Haselbach D, Kukura P
Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs.
1. Elife - published April 1, 2020
2. Reid MS, Kern DM, Brohawn SG
Integrating structural and evolutionary data to interpret variation and pathogenicity in Adapter Protein Complex 4 (AP-4).
1. Protein Sci - published April 1, 2020
2. Gadbery JE, Abraham A, Needle CD, Moth C, Sheehan J, Capra JA, Jackson LP
Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation.
1. Nat Med - published April 1, 2020
2. Johnson ECB, Dammer EB, Duong DM, Ping L, Zhou M, Yin L, Higginbotham LA, Guajardo A, White B, Troncoso JC, Thambisetty M, Montine TJ, Lee EB, Trojanowski JQ, Beach TG, Reiman EM, Haroutunian V, Wang M, Schadt E, Zhang B, Dickson DW, Ertekin-Taner N, Golde TE, Petyuk VA, De Jager PL, Bennett DA, Wingo TS, Rangaraju S, Hajjar I, Shulman JM, Lah JJ, Levey AI, Seyfried NT
Insulin and EGF receptor family members share parallel activation mechanisms.
1. Protein Sci - published April 1, 2020
2. Ferguson KM, Hu C, Lemmon MA
The ABC exporter IrtAB imports and reduces mycobacterial siderophores.
1. Nature - published April 1, 2020
2. Arnold FM, Weber MS, Gonda I, Gallenito MJ, Adenau S, Egloff P, Zimmermann I, Hutter CAJ, Hürlimann LM, Peters EE, Piel J, Meloni G, Medalia O, Seeger MA
Development of a 3Mut-Apex-Stabilized Envelope Trimer that Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses.
1. J Virol - published April 1, 2020
2. Chuang GY, Lai YT, Boyington JC, Cheng C, Geng H, Narpala S, Rawi R, Schmidt SD, Tsybovsky Y, Verardi R, Xu K, Yang Y, Zhang B, Chambers M, Changela A, Corrigan AR, Kong R, Olia AS, Ou L, Sarfo EK, Wang S, Wu W, Doria-Rose NA, McDermotta AB, Mascola JR, Kwong PD
Discovery and Structure-Activity Relationship Study of (Z)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.
1. J Med Chem - published April 1, 2020
2. Manz TD, Sivakumaren SC, Ferguson FM, Zhang T, Yasgar A, Seo HS, Ficarro SB, Card JD, Shim H, Miduturu CV, Simeonov A, Shen M, Marto JA, Dhe-Paganon S, Hall MD, Cantley LC, Gray NS
Author Correction: Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome.
1. Nat Commun - published April 1, 2020
2. Gopalakrishnan J, Mennella V, Blachon S, Zhai B, Smith AH, Megraw TL, Nicastro D, Gygi SP, Agard DA, Avidor-Reiss T
Assessment of Biased Agonism among Distinct Synthetic Cannabinoid Receptor Agonist Scaffolds.
1. ACS Pharmacol Transl Sci - published April 1, 2020
2. Wouters E, Walraed J, Robertson MJ, Meyrath M, Szpakowska M, Chevigné A, Skiniotis G, Stove C
Limited Dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction.
1. Elife - published April 1, 2020
2. Kan W, Enos MD, Korkmazhan E, Muennich S, Chen DH, Gammons MV, Vasishtha M, Bienz M, Dunn AR, Skiniotis G, Weis WI
The Role of Chemical Biology in the Discovery and Understanding of Ferroptosis.
1. Cell Chem Biol - published April 1, 2020
2. Dey M, Wagner B
Wss1 homolog from Candida albicans and its role in DNA-protein crosslink tolerance.
1. Mol Microbiol - published April 1, 2020
2. Homchan A, Sukted J, Mongkolsuk S, Jeruzalmi D, Matangkasombut O, Pakotiprapha D
The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution.
1. Cell - published April 1, 2020
2. Rozenblatt-Rosen O, Regev A, Oberdoerffer P, Nawy T, Hupalowska A, Rood JE, Ashenberg O, Cerami E, Coffey RJ, Demir E, Ding L, Esplin ED, Ford JM, Goecks J, Ghosh S, Gray JW, Guinney J, Hanlon SE, Hughes SK, Hwang ES, Iacobuzio-Donahue CA, Jané-Valbuena J, Johnson BE, Lau KS, Lively T, Mazzilli SA, Pe'er D, Santagata S, Shalek AK, Schapiro D, Snyder MP, Sorger PK, Spira AE, Srivastava S, Tan K, West RB, Williams EH, Human Tumor Atlas Network.
Crystal Contact Engineering Enables Efficient Capture and Purification of an Oxidoreductase by Technical Crystallization.
1. Biotechnol J - published April 1, 2020
2. Grob P, Huber M, Walla B, Hermann J, Janowski R, Niessing D, Hekmat D, Weuster-Botz D
A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
1. Cell - published April 1, 2020
2. Wandzik JM, Kouba T, Karuppasamy M, Pflug A, Drncova P, Provaznik J, Azevedo N, Cusack S
Insights on the regulation of the MLL/SET1 family histone methyltransferases.
1. Biochim Biophys Acta Gene Regul Mech - published April 1, 2020
2. Sha L, Ayoub A, Cho US, Dou Y
Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction.
1. J Clin Immunol - published April 1, 2020
2. Verboon JM, Mahmut D, Kim AR, Nakamura M, Abdulhay NJ, Nandakumar SK, Gupta N, Akie TE, Geddis AE, Manes B, Kapp ME, Hofmann I, Gabriel SB, Klein DE, Williams DA, Frangoul HA, Parkhurst SM, Crane GM, Cantor AB, Sankaran VG
Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling.
1. Proc Natl Acad Sci U S A - published April 1, 2020
2. Dollins DE, Bai W, Fridy PC, Otto JC, Neubauer JL, Gattis SG, Mehta KPM, York JD
Identification of new therapeutic targets and natural compounds against diffuse intrinsic pontine glioma (DIPG).
1. Bioorg Chem - published April 1, 2020
2. Chen J, Lin Z, Barrett L, Dai L, Qin Z
The CRISPR-RNA World: An Interview with Martin Jínek.
1. CRISPR J - published April 1, 2020
2. Davies K, Jínek M
Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2.
1. Cell - published April 1, 2020
2. Morita K, He S, Nowak RP, Wang J, Zimmerman MW, Fu C, Durbin AD, Martel MW, Prutsch N, Gray NS, Fischer ES, Look AT
Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically-Sensitive Activation Loop.
1. J Mol Biol - published April 1, 2020
2. Jaimes JA, André NM, Chappie JS, Millet JK, Whittaker GR
In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure-Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity.
1. Adv Sci (Weinh) - published April 1, 2020
2. Xu Z, Wise MC, Chokkalingam N, Walker S, Tello-Ruiz E, Elliott STC, Perales-Puchalt A, Xiao P, Zhu X, Pumroy RA, Fisher PD, Schultheis K, Schade E, Menis S, Guzman S, Andersen H, Broderick KE, Humeau LM, Muthumani K, Moiseenkova-Bell V, Schief WR, Weiner DB, Kulp DW
A Non-Canonical Calmodulin Target Motif Comprising a Polybasic Region and Lipidated Terminal Residue Regulates Localization.
1. Int J Mol Sci - published April 1, 2020
2. Grant BMM, Enomoto M, Ikura M, Marshall CB
VE-1902-A direct thrombin inhibitor with reversible covalent mechanism of action shows efficacy with reduced bleeding in rodent models of thrombosis.
1. Thromb Res - published April 1, 2020
2. Sivaraja M, Clemens DM, Sizikov S, Dash S, Xu C, Rienzo M, Yang B, Ryan M, Chattopadhyay M, Igoudin L, Chang SS, Keutzer S, Zalicki P, Estiarte MA, Shiau TP, Short KM, Williams DC, Datta A, Pozzi N, Di Cera E, Gibson CM, Fox KAA, Kita DB
Reply.
1. Retina - published April 1, 2020
2. Mahajan VB, Wood E
Cryo-EM structure of the human heteromeric amino acid transporter b^0,+AT-rBAT.
1. Sci Adv - published April 1, 2020
2. Yan R, Li Y, Shi Y, Zhou J, Lei J, Huang J, Zhou Q
Rapid prototyping and clinical testing of a reusable face shield for health care workers responding to the COVID-19 pandemic.
1. medRxiv - published April 1, 2020
2. Mostaghimi A, Antonini MJ, Plana D, Anderson PD, Beller B, Boyer EW, Fannin A, Freake J, Oakley R, Sinha MS, Smith L, Van C, Yang H, Sorger PK, LeBoeuf NR, Yu SH