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146 Member Publications for January 2020

Picking a nucleosome lock: Sequence- and structure-specific recognition of the nucleosome.
1. J Biosci - published January 23, 2020
2. Makowski MM, Gaullier G, Luger K
The CBX family of proteins in transcriptional repression and memory.
1. J Biosci - published January 23, 2020
2. Kim J, Kingston RE
Design and assessment of TRAP-CSP fusion antigens as effective malaria vaccines.
1. PLoS One - published January 23, 2020
2. Lu C, Song G, Beale K, Yan J, Garst E, Feng J, Lund E, Catteruccia F, Springer TA
Structure and Function of Roundabout Receptors.
1. Subcell Biochem - published January 16, 2020
2. Bisiak F, McCarthy AA
The Structures of Eukaryotic Transcription Pre-initiation Complexes and Their Functional Implications.
1. Subcell Biochem - published January 16, 2020
2. Greber BJ, Nogales E
Structure and activation mechanism of the BBSome membrane protein trafficking complex.
1. Elife - published January 15, 2020
2. Singh SK, Gui M, Koh F, Yip MC, Brown A
Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling.
1. PLoS One - published January 9, 2020
2. Luca VC, Miao Y, Li X, Hollander MJ, Kuo CJ, Garcia KC
Corrigendum to 'Plasma concentrations of long chain N-3 fatty acids in early and mid-pregnancy and risk of early preterm birth'.
1. EBioMedicine - published January 9, 2020
2. S F O, T I H, A L TL, M S, S G, C G, P H N, J W, J A L, J LR, A S C, J D F, E L G, W Z
PDBe: improved findability of macromolecular structure data in the PDB.
1. Nucleic Acids Res - published January 8, 2020
2. Armstrong DR, Berrisford JM, Conroy MJ, Gutmanas A, Anyango S, Choudhary P, Clark AR, Dana JM, Deshpande M, Dunlop R, Gane P, Gáborová R, Gupta D, Haslam P, Koča J, Mak L, Mir S, Mukhopadhyay A, Nadzirin N, Nair S, Paysan-Lafosse T, Pravda L, Sehnal D, Salih O, Smart O, Tolchard J, Varadi M, Svobodova-Vařeková R, Zaki H, Kleywegt GJ, Velankar S
Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir.
1. ACS Chem Biol - published January 8, 2020
2. Timm J, Kosovrasti K, Henes M, Leidner F, Hou S, Ali A, Kurt Yilmaz N, Schiffer CA
Author Correction: In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls.
1. Nat Commun - published January 8, 2020
2. Jiang W, Birtley JR, Hung SC, Wang W, Chiou SH, Macaubas C, Kornum B, Tian L, Huang H, Adler L, Weaver G, Lu L, Ilstad-Minnihan A, Somasundaram S, Ayyangar S, Davis MM, Stern LJ, Mellins ED
The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab.
1. Nat Commun - published January 8, 2020
2. Gasser P, Tarchevskaya SS, Guntern P, Brigger D, Ruppli R, Zbären N, Kleinboelting S, Heusser C, Jardetzky TS, Eggel A
Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions.
1. Nat Commun - published January 8, 2020
2. Ibarra IL, Hollmann NM, Klaus B, Augsten S, Velten B, Hennig J, Zaugg JB
A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture.
1. Elife - published January 8, 2020
2. Sabbagh MF, Nathans J
Biochemical characterization of biliverdins IXβ/δ generated by a selective heme oxygenase.
1. Biochem J - published January 8, 2020
2. Zhang B, Nesbitt NM, Pereira PJB, Bahou WF
Mapping and engineering the interaction between adiponectin and T-cadherin.
1. J Biol Chem - published January 8, 2020
2. Pascolutti R, Erlandson SC, Burri DJ, Zheng S, Kruse AC
The use of Trichomonas vaginalis purine nucleoside phosphorylase to activate fludarabine in the treatment of solid tumors.
1. Cancer Chemother Pharmacol - published January 8, 2020
2. Parker WB, Allan PW, Waud WR, Hong J, Gilbert-Ross M, Achyut BR, Joshi D, Behbahani T, Rab R, Ealick SE, Sorscher EJ
Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist.
1. J Biol Chem - published January 8, 2020
2. Azumaya CM, Linton EA, Risener CJ, Nakagawa T, Karakas E
Deep neural network affinity model for BACE inhibitors in D3R Grand Challenge 4.
1. J Comput Aided Mol Des - published January 8, 2020
2. Wang B, Ng HL
Quantitative Structural Interpretation of Protein Crosslinks.
1. Structure - published January 7, 2020
2. Filella-Merce I, Bardiaux B, Nilges M, Bouvier G
Revised Baseline Series of the International Contact Research Group.
1. Dermatitis - published January 7, 2020
2. Isaksson M, Ale I, Andersen KE, Cannavó A, Diepgen TL, Elsner P, Goh CL, Gonçalo M, Goossens A, Ljubojevic Hadzavdic S, Jerajani H, Lachapelle JM, Lee JY, Maibach HI, Matsunaga K, McFadden J, Nixon R, Pratt M, Puangpet P, Sasseville D, Verma K, Bruze M
The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target.
1. Cell Rep - published January 7, 2020
2. Wang W, Shin WJ, Zhang B, Choi Y, Yoo JS, Zimmerman MI, Frederick TE, Bowman GR, Gross ML, Leung DW, Jung JU, Amarasinghe GK
Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor.
1. Cell Rep - published January 7, 2020
2. Jenni S, Bloyet LM, Diaz-Avalos R, Liang B, Whelan SPJ, Grigorieff N, Harrison SC
Comparative modeling and docking of chemokine-receptor interactions with Rosetta.
1. Biochem Biophys Res Commun - published January 7, 2020
2. Wedemeyer MJ, Mueller BK, Bender BJ, Meiler J, Volkman BF
Delineating the Molecular Basis of the Calmodulin‒bMunc13-2 Interaction by Cross-Linking/Mass Spectrometry-Evidence for a Novel CaM Binding Motif in bMunc13-2.
1. Cells - published January 7, 2020
2. Piotrowski C, Moretti R, Ihling CH, Haedicke A, Liepold T, Lipstein N, Meiler J, Jahn O, Sinz A
Highly coupled transport can be achieved in free-exchange transport models.
1. J Gen Physiol - published January 6, 2020
2. Hussey GA, Thomas NE, Henzler-Wildman KA
Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity.
1. J Med Chem - published January 6, 2020
2. Dawidowski M, Kalel VC, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Mäser P, Tetko IV, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz GM
Electron cryotomography of intact motile cilia defines the basal body to axoneme transition.
1. J Cell Biol - published January 6, 2020
2. Greenan GA, Vale RD, Agard DA
The structural basis for cohesin-CTCF-anchored loops.
1. Nature - published January 6, 2020
2. Li Y, Haarhuis JHI, Cacciatore ÁS, Oldenkamp R, van Ruiten MS, Willems L, Teunissen H, Muir KW, de Wit E, Rowland BD, Panne D
Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress.
1. Elife - published January 6, 2020
2. Lam M, Marsters SA, Ashkenazi A, Walter P
Kinetic Control of Amyloidogenesis Calls for Unconventional Drugs To Fight Alzheimer's Disease.
1. ACS Chem Neurosci - published January 6, 2020
2. Caflisch A
Activation by substoichiometric inhibition.
1. Proc Natl Acad Sci U S A - published January 6, 2020
2. Merdanovic M, Burston SG, Schmitz AL, Köcher S, Knapp S, Clausen T, Kaiser M, Huber R, Ehrmann M
Biophysical prediction of protein-peptide interactions and signaling networks using machine learning.
1. Nat Methods - published January 6, 2020
2. Cunningham JM, Koytiger G, Sorger PK, AlQuraishi M
The mitochondrial carrier pathway transports non-canonical substrates with an odd number of transmembrane segments.
1. BMC Biol - published January 6, 2020
2. Rampelt H, Sucec I, Bersch B, Horten P, Perschil I, Martinou JC, van der Laan M, Wiedemann N, Schanda P, Pfanner N
Chaperone-assisted structure elucidation with DARPins.
1. Curr Opin Struct Biol - published January 6, 2020
2. Mittl PR, Ernst P, Plückthun A
The Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer.
1. Adv Exp Med Biol - published January 4, 2020
2. Liu X, Zurlo G, Zhang Q
Structural Biology of CRL Ubiquitin Ligases.
1. Adv Exp Med Biol - published January 4, 2020
2. Rusnac DV, Zheng N
Preparation, Characterization, and Properties of Novel Ti-Zr-Be-Co Bulk Metallic Glasses.
1. Materials (Basel) - published January 4, 2020
2. Gong P, Li F, Jin J
Tissue transglutaminase 2 regulates tumor cell tensional homeostasis by increasing contractility.
1. J Cell Sci - published January 3, 2020
2. Bordeleau F, Wang W, Simmons A, Antonyak MA, Cerione RA, Reinhart-King CA
The activation loop and substrate-binding cleft of glutaminase C are allosterically coupled.
1. J Biol Chem - published January 3, 2020
2. Li Y, Ramachandran S, Nguyen TT, Stalnecker CA, Cerione RA, Erickson JW
Genetic and phenotypic spectrum associated with IFIH1 gain-of-function.
1. Hum Mutat - published January 3, 2020
2. Rice GI, Park S, Gavazzi F, Adang LA, Ayuk LA, Van Eyck L, Seabra L, Barrea C, Battini R, Belot A, Berg S, Billette de Villemeur T, Bley AE, Blumkin L, Boespflug-Tanguy O, Briggs TA, Brimble E, Dale RC, Darin N, Debray FG, De Giorgis V, Denecke J, Doummar D, Drake Af Hagelsrum G, Eleftheriou D, Estienne M, Fazzi E, Feillet F, Galli J, Hartog N, Harvengt J, Heron B, Heron D, Kelly DA, Lev D, Levrat V, Livingston JH, Marti I, Mignot C, Mochel F, Nougues MC, Oppermann I, Pérez-Dueñas B, Popp B, Rodero MP, Rodriguez D, Saletti V, Sharpe C, Tonduti D, Vadlamani G, Van Haren K, Tomas Vila M, Vogt J, Wassmer E, Wiedemann A, Wilson CJ, Zerem A, Zweier C, Zuberi SM, Orcesi S, Vanderver AL, Hur S, Crow YJ
An in vitro platform for engineering and harnessing modular polyketide synthases.
1. Nat Commun - published January 3, 2020
2. Miyazawa T, Hirsch M, Zhang Z, Keatinge-Clay AT
Re-examining the spectra of macromolecules. Current practice of spectral quasi B-factor flattening.
1. J Struct Biol - published January 3, 2020
2. Vilas JL, Vargas J, Martinez M, Ramirez-Aportela E, Melero R, Jimenez-Moreno A, Garduño E, Conesa P, Marabini R, Maluenda D, Carazo JM, Sorzano COS
WDR5 is a conserved regulator of protein synthesis gene expression.
1. Nucleic Acids Res - published January 3, 2020
2. Bryan AF, Wang J, Howard GC, Guarnaccia AD, Woodley CM, Aho ER, Rellinger EJ, Matlock BK, Flaherty DK, Lorey SL, Chung DH, Fesik SW, Liu Q, Weissmiller AM, Tansey WP
HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions.
1. JCI Insight - published January 3, 2020
2. Easterhoff D, Pollara J, Luo K, Janus B, Gohain N, Williams LD, Tay MZ, Monroe A, Peachman K, Choe M, Min S, Lusso P, Zhang P, Go EP, Desaire H, Bonsignori M, Hwang KK, Beck C, Kakalis M, O'Connell RJ, Vasan S, Kim JH, Michael NL, Excler JL, Robb ML, Rerks-Ngarm S, Kaewkungwal J, Pitisuttithum P, Nitayaphan S, Sinangil F, Tartaglia J, Phogat S, Wiehe K, Saunders KO, Montefiori DC, Tomaras GD, Moody MA, Arthos J, Rao M, Joyce MG, Ofek GA, Ferrari G, Haynes BF
Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction.
1. Elife - published January 3, 2020
2. Wang L, Myasnikov A, Pan X, Walter P
AMPA receptor structure and auxiliary subunits.
1. J Physiol - published January 3, 2020
2. Kamalova A, Nakagawa T
Fundoscopy-directed genetic testing to re-evaluate negative whole exome sequencing results.
1. Orphanet J Rare Dis - published January 3, 2020
2. Cho A, Lima de Carvalho JR Jr, Tanaka AJ, Jauregui R, Levi SR, Bassuk AG, Mahajan VB, Tsang SH
Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12.
1. J Biol Chem - published January 3, 2020
2. Wu X, Schnitzler GR, Gao GF, Diamond B, Baker AR, Kaplan B, Williamson K, Westlake L, Lorrey S, Lewis TA, Garvie CW, Lange M, Hayat S, Seidel H, Doench J, Cherniack AD, Kopitz C, Meyerson M, Greulich H
The iron chelator Deferasirox causes severe mitochondrial swelling without depolarization due to a specific effect on inner membrane permeability.
1. Sci Rep - published January 3, 2020
2. Gottwald EM, Schuh CD, Drücker P, Haenni D, Pearson A, Ghazi S, Bugarski M, Polesel M, Duss M, Landau EM, Kaech A, Ziegler U, Lundby AKM, Lundby C, Dittrich PS, Hall AM
"Register-shift" insulin analogs uncover constraints of proteotoxicity in protein evolution.
1. J Biol Chem - published January 3, 2020
2. Rege NK, Liu M, Dhayalan B, Chen YS, Smith NA, Rahimi L, Sun J, Guo H, Yang Y, Haataja L, Phillips NFB, Whittaker J, Smith BJ, Arvan P, Ismail-Beigi F, Weiss MA
Correction to: LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells.
1. Cell Mol Immunol - published January 3, 2020
2. Li Z, Deng M, Huang F, Jin C, Sun S, Chen H, Liu X, He L, Sadek AH, Zhang CC
The scaffold-protein IQGAP1 enhances and spatially restricts the actin-nucleating activity of Diaphanous-related formin 1 (DIAPH1).
1. J Biol Chem - published January 3, 2020
2. Chen A, Arora PD, Lai CC, Copeland JW, Moraes TF, McCulloch CA, Lavoie BD, Wilde A
DSS1 interacts with and stimulates RAD52 to promote the repair of DSBs.
1. Nucleic Acids Res - published January 2, 2020
2. Stefanovie B, Hengel SR, Mlcouskova J, Prochazkova J, Spirek M, Nikulenkov F, Nemecek D, Koch BG, Bain FE, Yu L, Spies M, Krejci L
Quantitative microscopy reveals dynamics and fate of clustered IRE1α.
1. Proc Natl Acad Sci U S A - published January 2, 2020
2. Belyy V, Tran NH, Walter P
Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B.
1. Pathog Immun - published January 2, 2020
2. Joyce MG, Bao A, Chen M, Georgiev IS, Ou L, Bylund T, Druz A, Kong WP, Peng D, Rundlet EJ, Van Galen JG, Wang S, Yang Y, Zhang B, Chuang GY, McLellan JS, Graham BS, Mascola JR, Kwong PD
Apoptosis signaling molecules as treatment targets in head and neck squamous cell carcinoma.
1. Laryngoscope - published January 2, 2020
2. Ow TJ, Thomas C, Fulcher CD, Chen J, López A, Reyna DE, Prystowsky MB, Smith RV, Schiff BA, Rosenblatt G, Belbin TJ, Harris TM, Childs GC, Kawachi N, Schlecht NF, Gavathiotis E
Measuring local-directional resolution and local anisotropy in cryo-EM maps.
1. Nat Commun - published January 2, 2020
2. Vilas JL, Tagare HD, Vargas J, Carazo JM, Sorzano COS
Short direct repeats in the 3'-untranslated region are involved in subgenomic flaviviral RNA production.
1. J Virol - published January 2, 2020
2. Zhang QY, Li XF, Niu X, Li N, Wang HJ, Deng CL, Ye HQ, Huang XY, Chen Q, Xu YP, Dong HL, Li XD, Zhao H, Shi PY, Yuan ZM, Gong P, Fang X, Qin CF, Zhang B
NMR Experiments for Studies of Dilute and Condensed Protein Phases: Application to the Phase-Separating Protein CAPRIN1.
1. J Am Chem Soc - published January 2, 2020
2. Wong LE, Kim TH, Muhandiram DR, Forman-Kay JD, Kay LE
Developing Inhibitors of the p47phox-p22phox Protein-Protein Interaction by Fragment-Based Drug Discovery.
1. J Med Chem - published January 2, 2020
2. Solbak SMØ, Zang J, Narayanan D, Høj LJ, Bucciarelli S, Softley C, Meier S, Langkilde AE, Gotfredsen CH, Sattler M, Bach A
Small-Molecule Antagonists of the RIG-I Innate Immune Receptor.
1. ACS Chem Biol - published January 2, 2020
2. Rawling DC, Jagdmann GE Jr, Potapova O, Pyle AM
The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding.
1. Elife - published January 2, 2020
2. Bodrug T, Wilson-Kubalek EM, Nithianantham S, Thompson AF, Alfieri A, Gaska I, Major J, Debs G, Inagaki S, Gutierrez P, Gheber L, McKenney RJ, Sindelar CV, Milligan R, Stumpff J, Rosenfeld SS, Forth ST, Al-Bassam J
Confluence of theory and experiment reveals the catalytic mechanism of the Varkud satellite ribozyme.
1. Nat Chem - published January 2, 2020
2. Ganguly A, Weissman BP, Giese TJ, Li NS, Hoshika S, Rao S, Benner SA, Piccirilli JA, York DM
Branched kissing loops for the construction of diverse RNA homooligomeric nanostructures.
1. Nat Chem - published January 2, 2020
2. Liu D, Geary CW, Chen G, Shao Y, Li M, Mao C, Andersen ES, Piccirilli JA, Rothemund PWK, Weizmann Y
Spin-labeled nanobodies as protein conformational reporters for electron paramagnetic resonance in cellular membranes.
1. Proc Natl Acad Sci U S A - published January 2, 2020
2. Galazzo L, Meier G, Timachi MH, Hutter CAJ, Seeger MA, Bordignon E
Structural Insights into the Unique Activation Mechanisms of a Non-classical Calpain and Its Disease-Causing Variants.
1. Cell Rep - published January 2, 2020
2. Velez G, Sun YJ, Khan S, Yang J, Herrmann J, Chemudupati T, MacLaren RE, Gakhar L, Wakatsuki S, Bassuk AG, Mahajan VB
Publisher Correction: Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody.
1. Nat Struct Mol Biol - published January 2, 2020
2. Yang Z, Wang H, Liu AZ, Gristick HB, Bjorkman PJ
Cryo-Electron Microscopy Structure of the αIIbβ3-Abciximab Complex.
1. Arterioscler Thromb Vasc Biol - published January 2, 2020
2. Nešić D, Zhang Y, Spasic A, Li J, Provasi D, Filizola M, Walz T, Coller BS
Protein C activator AB002 rapidly interrupts thrombus development in baboons and appears safe in a first-in-human trial.
1. Blood - published January 2, 2020
2. Tucker EI, Verbout NG, Markway BD, Wallisch M, Lorentz C, Hinds M, Shatzel JJ, Pelc LA, Wood DC, McCarty O, Di Cera E, Gruber A
The C. difficile toxin B membrane translocation machinery is an evolutionarily conserved protein delivery apparatus.
1. Nat Commun - published January 2, 2020
2. Orrell KE, Mansfield MJ, Doxey AC, Melnyk RA
Uncovering the activities, biological roles, and regulation of bacterial cell wall hydrolases and tailoring enzymes.
1. J Biol Chem - published January 2, 2020
2. Do T, Page JE, Walker S
Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake.
1. Nat Commun - published January 2, 2020
2. Jakobi AJ, Huber ST, Mortensen SA, Schultz SW, Palara A, Kuhm T, Shrestha BK, Lamark T, Hagen WJH, Wilmanns M, Johansen T, Brech A, Sachse C
Structural and Functional Characterization of the Dominant Negative P-Loop Lysine Mutation in the Dynamin Superfamily Protein Vps1.
1. Protein Sci - published January 2, 2020
2. Tornabene BA, Varlakhanova NV, Hosford CJ, Chappie JS, Ford MGJ
Allosteric activation of MALT1 by its ubiquitin-binding Ig3 domain.
1. Proc Natl Acad Sci U S A - published January 2, 2020
2. Schairer R, Hall G, Zhang M, Cowan R, Baravalle R, Muskett FW, Coombs PJ, Mpamhanga C, Hale LR, Saxty B, Iwaszkiewicz J, Décaillet C, Perroud M, Carr MD, Thome M
Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing.
1. Nat Commun - published January 2, 2020
2. Li K, Liu Y, Cao H, Zhang Y, Gu Z, Liu X, Yu A, Kaphle P, Dickerson KE, Ni M, Xu J
Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements.
1. Nat Commun - published January 2, 2020
2. Henderson R, Lu M, Zhou Y, Mu Z, Parks R, Han Q, Hsu AL, Carter E, Blanchard SC, Edwards RJ, Wiehe K, Saunders KO, Borgnia MJ, Bartesaghi A, Mothes W, Haynes BF, Acharya P, Munir Alam S
Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly.
1. PLoS Pathog - published January 2, 2020
2. Dick RA, Xu C, Morado DR, Kravchuk V, Ricana CL, Lyddon TD, Broad AM, Feathers JR, Johnson MC, Vogt VM, Perilla JR, Briggs JAG, Schur FKM
Memory of environmental conditions across generations affects the acclimation potential of Scots pine.
1. Plant Cell Environ - published January 2, 2020
2. Bose AK, Moser B, Rigling A, Lehmann MM, Milcu A, Peter M, Rellstab C, Wohlgemuth T, Gessler A
The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis.
1. BMC Biol - published January 2, 2020
2. Joshi A, Dai L, Liu Y, Lee J, Ghahhari NM, Segala G, Beebe K, Jenkins LM, Lyons GC, Bernasconi L, Tsai FTF, Agard DA, Neckers L, Picard D
Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site.
1. Elife - published January 2, 2020
2. Brams M, Govaerts C, Kambara K, Price KL, Spurny R, Gharpure A, Pardon E, Evans GL, Bertrand D, Lummis SC, Hibbs RE, Steyaert J, Ulens C
iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates.
1. Nat Med - published January 2, 2020
2. Laperle AH, Sances S, Yucer N, Dardov VJ, Garcia VJ, Ho R, Fulton AN, Jones MR, Roxas KM, Avalos P, West D, Banuelos MG, Shu Z, Murali R, Maidment NT, Van Eyk JE, Tagliati M, Svendsen CN
Pel polysaccharide biosynthesis requires an inner membrane complex comprised of PelD, PelE, PelF and PelG.
1. J Bacteriol - published January 2, 2020
2. Whitfield GB, Marmont LS, Ostaszewski A, Rich JD, Whitney JC, Parsek MR, Harrison JJ, Howell PL
Assessment of the nucleotide modifications in the high-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit.
1. Nucleic Acids Res - published January 2, 2020
2. Stojković V, Myasnikov AG, Young ID, Frost A, Fraser JS, Fujimori DG
Decoding allosteric communication pathways in protein lysine acetyltransferase.
1. Int J Biol Macromol - published January 2, 2020
2. Rehman AU, Rahman MU, Lu S, Liu H, Li JY, Arshad T, Wadood A, Ng HL, Chen HF
The human dimension in contemporary biological research.
1. Nat Struct Mol Biol - published January 2, 2020
2. Mancia F, Harrison SC
Structure-Function Analyses of a Keratin Heterotypic Complex Identify Specific Keratin Regions Involved in Intermediate Filament Assembly.
1. Structure - published January 2, 2020
2. Lee CH, Kim MS, Li S, Leahy DJ, Coulombe PA
TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential.
1. Nat Commun - published January 2, 2020
2. Zhang H, Pan Y, Hu L, Hudson MA, Hofstetter KS, Xu Z, Rong M, Wang Z, Prasad BVV, Lockless SW, Chiu W, Zhou M
A mouse model for Kinesin Family Member 11 (Kif11)-associated familial exudative vitreoretinopathy.
1. Hum Mol Genet - published January 2, 2020
2. Wang Y, Smallwood PM, Williams J, Nathans J
Structure and Characterization of Crimean-Congo Hemorrhagic Fever Virus GP38.
1. J Virol - published January 2, 2020
2. Mishra AK, Moyer CL, Abelson DM, Deer DJ, El Omari K, Duman R, Lobel L, Lutwama JJ, Dye JM, Wagner A, Chandran K, Cross RW, Geisbert TW, Zeitlin L, Bornholdt ZA, McLellan JS
The structure of the Legionella response regulator LqsR reveals amino acids critical for phosphorylation and dimerization.
1. Mol Microbiol - published January 2, 2020
2. Hochstrasser R, Hutter CAJ, Arnold FM, Bärlocher K, Seeger MA, Hilbi H
Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.
1. Mol Cell - published January 2, 2020
2. Gonatopoulos-Pournatzis T, Niibori R, Salter EW, Weatheritt RJ, Tsang B, Farhangmehr S, Liang X, Braunschweig U, Roth J, Zhang S, Henderson T, Sharma E, Quesnel-Vallières M, Permanyer J, Maier S, Georgiou J, Irimia M, Sonenberg N, Forman-Kay JD, Gingras AC, Collingridge GL, Woodin MA, Cordes SP, Blencowe BJ
Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody.
1. Cell - published January 2, 2020
2. Schommers P, Gruell H, Abernathy ME, Tran MK, Dingens AS, Gristick HB, Barnes CO, Schoofs T, Schlotz M, Vanshylla K, Kreer C, Weiland D, Holtick U, Scheid C, Valter MM, van Gils MJ, Sanders RW, Vehreschild JJ, Cornely OA, Lehmann C, Fätkenheuer G, Seaman MS, Bloom JD, Bjorkman PJ, Klein F
Cryoelectron Microscopy Structure of a Yeast Centromeric Nucleosome at 2.7 Å Resolution.
1. Structure - published January 2, 2020
2. Migl D, Kschonsak M, Arthur CP, Khin Y, Harrison SC, Ciferri C, Dimitrova YN
T cell receptors, mechanosensors, catch bonds and immunotherapy.
1. Prog Biophys Mol Biol - published January 2, 2020
2. Wang JH
Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss.
1. Mol Cell - published January 2, 2020
2. Liu X, Simon JM, Xie H, Hu L, Wang J, Zurlo G, Fan C, Ptacek TS, Herring L, Tan X, Li M, Baldwin AS, Kim WY, Wu T, Kirschner MW, Gong K, Zhang Q
Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice.
1. Adv Biol Regul - published January 2, 2020
2. Hale AT, Brown RE, Luka Z, Hudson BH, Matta P, Williams CS, York JD
Getting a clinical innovation into practice: An introduction to implementation strategies.
1. Psychiatry Res - published January 1, 2020
2. Kirchner JE, Smith JL, Powell BJ, Waltz TJ, Proctor EK
NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods.
1. Mol Cell Proteomics - published January 1, 2020
2. De Leoz MLA, Duewer DL, Fung A, Liu L, Yau HK, Potter O, Staples GO, Furuki K, Frenkel R, Hu Y, Sosic Z, Zhang P, Altmann F, Grunwald-Grube C, Shao C, Zaia J, Evers W, Pengelley S, Suckau D, Wiechmann A, Resemann A, Jabs W, Beck A, Froehlich JW, Huang C, Li Y, Liu Y, Sun S, Wang Y, Seo Y, An HJ, Reichardt NC, Ruiz JE, Archer-Hartmann S, Azadi P, Bell L, Lakos Z, An Y, Cipollo JF, Pucic-Bakovic M, Štambuk J, Lauc G, Li X, Wang PG, Bock A, Hennig R, Rapp E, Creskey M, Cyr TD, Nakano M, Sugiyama T, Leung PA, Link-Lenczowski P, Jaworek J, Yang S, Zhang H, Kelly T, Klapoetke S, Cao R, Kim JY, Lee HK, Lee JY, Yoo JS, Kim SR, Suh SK, de Haan N, Falck D, Lageveen-Kammeijer GSM, Wuhrer M, Emery RJ, Kozak RP, Liew LP, Royle L, Urbanowicz PA, Packer NH, Song X, Everest-Dass A, Lattová E, Cajic S, Alagesan K, Kolarich D, Kasali T, Lindo V, Chen Y, Goswami K, Gau B, Amunugama R, Jones R, Stroop CJM, Kato K, Yagi H, Kondo S, Yuen CT, Harazono A, Shi X, Magnelli PE, Kasper BT, Mahal L, Harvey DJ, O'Flaherty R, Rudd PM, Saldova R, Hecht ES, Muddiman DC, Kang J, Bhoskar P, Menard D, Saati A, Merle C, Mast S, Tep S, Truong J, Nishikaze T, Sekiya S, Shafer A, Funaoka S, Toyoda M, de Vreugd P, Caron C, Pradhan P, Tan NC, Mechref Y, Patil S, Rohrer JS, Chakrabarti R, Dadke D, Lahori M, Zou C, Cairo C, Reiz B, Whittal RM, Lebrilla CB, Wu L, Guttman A, Szigeti M, Kremkow BG, Lee KH, Sihlbom C, Adamczyk B, Jin C, Karlsson NG, Örnros J, Larson G, Nilsson J, Meyer B, Wiegandt A, Komatsu E, Perreault H, Bodnar ED, Said N, Francois YN, Leize-Wagner E, Maier S, Zeck A, Heck AJR, Yang Y, Haselberg R, Yu YQ, Alley W, Leone JW, Yuan H, Stein SE
Structural analyses of inositol phosphate second messengers bound to signaling effector proteins.
1. Adv Biol Regul - published January 1, 2020
2. Blind RD
Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.
1. Cancer Discov - published January 1, 2020
2. Hobbs GA, Baker NM, Miermont AM, Thurman RD, Pierobon M, Tran TH, Anderson AO, Waters AM, Diehl JN, Papke B, Hodge RG, Klomp JE, Goodwin CM, DeLiberty JM, Wang J, Ng RWS, Gautam P, Bryant KL, Esposito D, Campbell SL, Petricoin EF 3rd, Simanshu DK, Aguirre AJ, Wolpin BM, Wennerberg K, Rudloff U, Cox AD, Der CJ
Molecular Basis of Opioid Action: From Structures to New Leads.
1. Biol Psychiatry - published January 1, 2020
2. Manglik A
Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu.
1. Nat Methods - published January 1, 2020
2. Ho CM, Li X, Lai M, Terwilliger TC, Beck JR, Wohlschlegel J, Goldberg DE, Fitzpatrick AWP, Zhou ZH
FACT caught in the act of manipulating the nucleosome.
1. Nature - published January 1, 2020
2. Liu Y, Zhou K, Zhang N, Wei H, Tan YZ, Zhang Z, Carragher B, Potter CS, D'Arcy S, Luger K
A Regulatory Cysteine Residue Mediates Reversible Inactivation of NAD⁺-Dependent Aldehyde Dehydrogenases to Promote Oxidative Stress Response.
1. ACS Chem Biol - published January 1, 2020
2. Zhang Y, Wang M, Lin H
In vitro trackable assembly of RNA-specific nucleocapsids of the respiratory syncytial virus.
1. J Biol Chem - published January 1, 2020
2. Gao Y, Cao D, Ahn HM, Swain A, Hill S, Ogilvie C, Kurien M, Rahmatullah T, Liang B
Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor.
1. J Med Chem - published January 1, 2020
2. Lefranc J, Schulze VK, Hillig RC, Briem H, Prinz F, Mengel A, Heinrich T, Balint J, Rengachari S, Irlbacher H, Stöckigt D, Bömer U, Bader B, Gradl SN, Nising CF, von Nussbaum F, Mumberg D, Panne D, Wengner AM
Characterizing Protein-Ligand Binding Using Atomistic Simulation and Machine Learning: Application to Drug Resistance in HIV-1 Protease.
1. J Chem Theory Comput - published January 1, 2020
2. Whitfield TW, Ragland DA, Zeldovich KB, Schiffer CA
Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide.
1. PLoS One - published January 1, 2020
2. Jaber Chehayeb R, Stiegler AL, Boggon TJ
X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance.
1. Biochemistry - published January 1, 2020
2. Thomaston JL, Konstantinidi A, Liu L, Lambrinidis G, Tan J, Caffrey M, Wang J, Degrado WF, Kolocouris A
Small Molecule Compounds That Inhibit Antioxidant Response Gene Expression in an Inducer-Dependent Manner.
1. ACS Infect Dis - published January 1, 2020
2. Edwards MR, Liu G, De S, Sourimant J, Pietzsch C, Johnson B, Amarasinghe GK, Leung DW, Bukreyev A, Plemper RK, Aron Z, Bowlin TL, Moir DT, Basler CF
Small Molecule Inhibitor Screen Reveals Calcium Channel Signaling as a Mechanistic Mediator of Clostridium difficile TcdB-Induced Necrosis.
1. ACS Chem Biol - published January 1, 2020
2. Farrow MA, Chumber NM, Bloch SC, King M, Moton-Melancon K, Shupe J, Washington MK, Spiller BW, Lacy DB
l-Fucose prevention of renal ischaemia/reperfusion injury in Mice.
1. FASEB J - published January 1, 2020
2. Howard MC, Nauser CL, Farrar CA, Wallis R, Sacks SH
Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome.
1. Elife - published January 1, 2020
2. Worden EJ, Zhang X, Wolberger C
Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane.
1. Elife - published January 1, 2020
2. Ge Y, Shi X, Boopathy S, McDonald J, Smith AW, Chao LH
A key interaction with RPA orients XPA in NER complexes.
1. Nucleic Acids Res - published January 1, 2020
2. Topolska-Woś AM, Sugitani N, Cordoba JJ, Le Meur KV, Le Meur RA, Kim HS, Yeo JE, Rosenberg D, Hammel M, Schärer OD, Chazin WJ
Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex.
1. Cell Res - published January 1, 2020
2. Jia N, Xie W, de la Cruz MJ, Eng ET, Patel DJ
Structural basis for adhesion G protein-coupled receptor Gpr126 function.
1. Nat Commun - published January 1, 2020
2. Leon K, Cunningham RL, Riback JA, Feldman E, Li J, Sosnick TR, Zhao M, Monk KR, Araç D
Resting state structure of the hyperdepolarization activated two-pore channel 3.
1. Proc Natl Acad Sci U S A - published January 1, 2020
2. Dickinson MS, Myasnikov A, Eriksen J, Poweleit N, Stroud RM
Cryo-EM structure of full-length HIV-1 Env bound with the Fab of antibody PG16.
1. J Mol Biol - published January 1, 2020
2. Pan J, Peng H, Chen B, Harrison SC
PISA-SPARKY: an interactive SPARKY plugin to analyze oriented solid-state NMR spectra of helical membrane proteins.
1. Bioinformatics - published January 1, 2020
2. Weber DK, Wang S, Markley JL, Veglia G, Lee W
Differences in the chitinolytic activity of mammalian chitinases on soluble and insoluble substrates.
1. Protein Sci - published January 1, 2020
2. Barad BA, Liu L, Diaz RE, Basilio R, Van Dyken SJ, Locksley RM, Fraser JS
Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site.
1. MAbs - published January 1, 2020
2. Hanf KJM, Arndt JW, Liu Y, Gong BJ, Rushe M, Sopko R, Massol R, Smith B, Gao Y, Dalkilic-Liddle I, Lee X, Mojta S, Shao Z, Mi S, Pepinsky RB
Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan.
1. Nat Microbiol - published January 1, 2020
2. Do T, Schaefer K, Santiago AG, Coe KA, Fernandes PB, Kahne D, Pinho MG, Walker S
Structural basis of substrate recognition by a polypeptide processing and secretion transporter.
1. Elife - published January 1, 2020
2. Kieuvongngam V, Olinares PDB, Palillo A, Oldham ML, Chait BT, Chen J
Structure-based design of a potent and selective covalent inhibitor for SRC kinase that targets a p-Loop cysteine.
1. J Med Chem - published January 1, 2020
2. Du G, Rao S, Gurbani D, Henning NJ, Jiang J, Che J, Yang A, Ficarro SB, Marto JA, Aguirre AJ, Sorger PK, Westover KD, Zhang T, Gray NS
Author Correction: FRQ-CK1 interaction determines the period of circadian rhythms in Neurospora.
1. Nat Commun - published January 1, 2020
2. Liu X, Chen A, Caicedo-Casso A, Cui G, Du M, He Q, Lim S, Kim HJ, Hong CI, Liu Y
Broad dengue neutralization in mosquitoes expressing an engineered antibody.
1. PLoS Pathog - published January 1, 2020
2. Buchman A, Gamez S, Li M, Antoshechkin I, Li HH, Wang HW, Chen CH, Klein MJ, Duchemin JB, Crowe JE Jr, Paradkar PN, Akbari OS
Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc.
1. Nature - published January 1, 2020
2. Staus DP, Hu H, Robertson MJ, Kleinhenz ALW, Wingler LM, Capel WD, Latorraca NR, Lefkowitz RJ, Skiniotis G
The Bcl-2 Family: Ancient Origins, Conserved Structures, and Divergent Mechanisms.
1. Biomolecules - published January 1, 2020
2. Banjara S, Suraweera CD, Hinds MG, Kvansakul M
Structure of the neurotensin receptor 1 in complex with β-arrestin 1.
1. Nature - published January 1, 2020
2. Huang W, Masureel M, Qianhui Q, Janetzko J, Inoue A, Kato HE, Robertson MJ, Nguyen KC, Glenn JS, Skiniotis G, Kobilka BK
Mycobacterium marinum produces distinct mycobactin and carboxymycobactin siderophores to promote growth in broth and phagocytes.
1. Cell Microbiol - published January 1, 2020
2. Knobloch P, Koliwer-Brandl H, Arnold FM, Hanna N, Gonda I, Adenau S, Personnic N, Barisch C, Seeger MA, Soldati T, Hilbi H
Structural analysis of lecithin:cholesterol acyltransferase bound to high density lipoprotein particles.
1. Commun Biol - published January 1, 2020
2. Manthei KA, Patra D, Wilson CJ, Fawaz MV, Piersimoni L, Shenkar JC, Yuan W, Andrews PC, Engen JR, Schwendeman A, Ohi MD, Tesmer JJG
The Cap-Snatching Mechanism of Bunyaviruses.
1. Trends Microbiol - published January 1, 2020
2. Olschewski S, Cusack S, Rosenthal M
Modulated control of DNA supercoiling balance by the DNA-wrapping domain of bacterial gyrase.
1. Nucleic Acids Res - published January 1, 2020
2. Hobson MJ, Bryant Z, Berger JM
Structure of a rabies virus polymerase complex from electron cryo-microscopy.
1. Proc Natl Acad Sci U S A - published January 1, 2020
2. Horwitz JA, Jenni S, Harrison SC, Whelan SPJ
Constructing a yeast to express the largest cellulosome complex on the cell surface.
1. Proc Natl Acad Sci U S A - published January 1, 2020
2. Anandharaj M, Lin YJ, Rani RP, Nadendla EK, Ho MC, Huang CC, Cheng JF, Chang JJ, Li WH
Cryo-EM structure of the respiratory syncytial virus RNA polymerase.
1. Nat Commun - published January 1, 2020
2. Cao D, Gao Y, Roesler C, Rice S, D'Cunha P, Zhuang L, Slack J, Domke M, Antonova A, Romanelli S, Keating S, Forero G, Juneja P, Liang B
Reporter Assays for Ebola Virus Nucleoprotein Oligomerization, Virion-Like Particle Budding, and Minigenome Activity Reveal the Importance of Nucleoprotein Amino Acid Position 111.
1. Viruses - published January 1, 2020
2. Lin AE, Diehl WE, Cai Y, Finch CL, Akusobi C, Kirchdoerfer RN, Bollinger L, Schaffner SF, Brown EA, Saphire EO, Andersen KG, Kuhn JH, Luban J, Sabeti PC
A high-throughput chemotaxis detection method for CCR4+ T cell migration inhibition using image cytometry.
1. J Immunol Methods - published January 1, 2020
2. Magnotti EL, Chan LL, Zhu Q, Marasco WA
Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β.
1. Cell - published January 1, 2020
2. Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL
A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin.
1. Mol Cell - published January 1, 2020
2. Chen S, Jiao L, Liu X, Yang X, Liu X
A Team-Based Early Action Protocol to Address Ethical Concerns in the Intensive Care Unit.
1. Am J Crit Care - published January 1, 2020
2. Pavlish CL, Henriksen J, Brown-Saltzman K, Robinson EM, Warda US, Farra C, Chen B, Jakel P
DNA-Mediated Assembly of Multispecific Antibodies for T Cell Engaging and Tumor Killing.
1. Adv Sci (Weinh) - published January 1, 2020
2. Pan L, Cao C, Run C, Zhou L, Chou JJ
Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement.
1. Cell Rep - published January 1, 2020
2. Berry KN, Brett TJ
Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation.
1. Nat Cancer - published January 1, 2020
2. Wu L, Seung E, Xu L, Rao E, Lord DM, Wei RR, Cortez-Retamozo V, Ospina B, Posternak V, Ulinski G, Piepenhagen P, Francesconi E, El-Murr N, Beil C, Kirby P, Li A, Fretland J, Vicente R, Deng G, Dabdoubi T, Cameron B, Bertrand T, Ferrari P, Pouzieux S, Lemoine C, Prades C, Park A, Qiu H, Song Z, Zhang B, Sun F, Chiron M, Rao S, Radošević K, Yang ZY, Nabel GJ