Member Publications

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125 Member Publications for August 2019

Cryo-EM studies of NAIP-NLRC4 inflammasomes.
1. Methods Enzymol - published August 29, 2019
2. Haloupek N, Grob P, Tenthorey J, Vance RE, Nogales E
Kinetics of DNA-protein association and dissociation by stopped-flow spectroscopy.
1. Methods Enzymol - published August 29, 2019
2. Rudolph J, Luger K
Analysis of human cGAS activity and structure.
1. Methods Enzymol - published August 29, 2019
2. Zhou W, Whiteley AT, Kranzusch PJ
Rap GTPase Interactor: A Potential Marker for Cancer Prognosis Following Kidney Transplantation.
1. Front Oncol - published August 27, 2019
2. Fu Q, Yang F, Liao M, Feeney NJ, Deng K, Serifis N, Wei L, Yang H, Chen K, Deng S, Markmann JF
A novel RNA variant of human concentrative nucleoside transporter 1 (hCNT1) that is a potential cancer biomarker.
1. Exp Hematol Oncol - published August 24, 2019
2. Wang C, Buolamwini JK
Teneurin Structure: Splice Variants of a Bacterial Toxin Homolog Specifies Synaptic Connections.
1. Front Neurosci - published August 24, 2019
2. Araç D, Li J
Structural and functional analysis of the Acinetobacter baumannii BlsA photoreceptor and regulatory protein.
1. PLoS One - published August 16, 2019
2. Wood CR, Squire MS, Finley NL, Page RC, Actis LA
Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.
1. Elife - published August 9, 2019
2. Knott GJ, Cress BF, Liu JJ, Thornton BW, Lew RJ, Al-Shayeb B, Rosenberg DJ, Hammel M, Adler BA, Lobba MJ, Xu M, Arkin AP, Fellmann C, Doudna JA
A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites.
1. Nat Commun - published August 9, 2019
2. Koirala D, Shao Y, Koldobskaya Y, Fuller JR, Watkins AM, Shelke SA, Pilipenko EV, Das R, Rice PA, Piccirilli JA
A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade.
1. Nat Commun - published August 9, 2019
2. Zheng Y, Qiu Y, Grace CRR, Liu X, Klionsky DJ, Schulman BA
Cryo-EM structure of the native rhodopsin dimer in nanodiscs.
1. J Biol Chem - published August 9, 2019
2. Zhao DY, Poege M, Morizumi T, Gulati S, Van Eps N, Zhang J, Miszta P, Filipek S, Mahamid J, Plitzko JM, Baumeister W, Ernst OP, Palczewski K
Manipulation by Methylation: Garnishing mRNAs with m6Am.
1. Mol Cell - published August 8, 2019
2. Doxtader KA, Nam Y
Dynamic regulatory features of the protein tyrosine kinases.
1. Biochem Soc Trans - published August 8, 2019
2. Amatya N, Lin DY, Andreotti AH
In Vitro Assessment of Putative PD-1/PD-L1 Inhibitors: Suggestions of an Alternative Mode of Action.
1. ACS Med Chem Lett - published August 8, 2019
2. Blevins DJ, Hanley R, Bolduc T, Powell DA, Gignac M, Walker K, Carr MD, Hof F, Wulff JE
Aspartate Residues Far from the Active Site Drive O-GlcNAc Transferase Substrate Selection.
1. J Am Chem Soc - published August 7, 2019
2. Joiner CM, Levine ZG, Aonbangkhen C, Woo CM, Walker S
Opposing T cell responses in experimental autoimmune encephalomyelitis.
1. Nature - published August 7, 2019
2. Saligrama N, Zhao F, Sikora MJ, Serratelli WS, Fernandes RA, Louis DM, Yao W, Ji X, Idoyaga J, Mahajan VB, Steinmetz LM, Chien YH, Hauser SL, Oksenberg JR, Garcia KC, Davis MM
Strain-dependent Activation and Inhibition of Human Immunodeficiency Virus (HIV-1) Entry by a Specific PF-68742 Stereoisomer.
1. J Virol - published August 7, 2019
2. Zhao C, Princiotto AM, Nguyen HT, Zou S, Zhao ML, Zhang S, Herschhorn A, Farrell M, Pahil K, Melillo B, Sambasivarao SV, Abrams C, Smith AB 3rd, Madani N, Sodroski J
The structure of a highly conserved picocyanobacterial protein reveals a Tudor domain with an RNA binding function.
1. J Biol Chem - published August 7, 2019
2. Bauer KM, Dicovitsky R, Pellegrini M, Zhaxybayeva O, Ragusa MJ
N6-Methyladenosine Modification Controls Circular RNA Immunity.
1. Mol Cell - published August 7, 2019
2. Chen YG, Chen R, Ahmad S, Verma R, Kasturi SP, Amaya L, Broughton JP, Kim J, Cadena C, Pulendran B, Hur S, Chang HY
Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2.
1. Biochemistry - published August 6, 2019
2. Srivastava D, Nandi S, Dey M
Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export.
1. Nat Commun - published August 6, 2019
2. Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomès R, Privé GG, Annaert W, Schwake M, Heeren J, Lüllmann-Rauch R, Grinstein S, Ikonen E, Saftig P, Neculai D
Neuregulin Signaling is a Mechanism of Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma.
1. Mol Cancer Ther - published August 6, 2019
2. Baro M, Lopez Sambrooks C, Burtness BA, Lemmon MA, Contessa JN
A strategy for the selection of monovalent antibodies that span protein dimer interfaces.
1. J Biol Chem - published August 6, 2019
2. Spangler JB, Moraga I, Jude KM, Savvides CS, Garcia KC
Structural Basis for the Differential Regulatory Roles of the PDZ Domain in C-Terminal Processing Proteases.
1. MBio - published August 6, 2019
2. Chueh CK, Som N, Ke LC, Ho MR, Reddy M, Chang CI
Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis.
1. Structure - published August 6, 2019
2. Zhou Y, Millott R, Kim HJ, Peng S, Edwards RA, Skene-Arnold T, Hammel M, Lees-Miller SP, Tainer JA, Holmes CFB, Glover JNM
The Molecular Function of σ Receptors: Past, Present, and Future.
1. Trends Pharmacol Sci - published August 3, 2019
2. Schmidt HR, Kruse AC
The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10.
1. Open Biol - published August 3, 2019
2. Paulson CN, John K, Baxley RM, Kurniawan F, Orellana K, Francis R, Sobeck A, Eichman BF, Chazin WJ, Aihara H, Georg GI, Hawkinson JE, Bielinsky AK
Life During Wartime: A Personal Recollection of the Circa 1990 Prestegard Lab and Its Contributions to Membrane Biophysics.
1. J Membr Biol - published August 3, 2019
2. Sanders CR
Structure of the Respiratory Syncytial Virus Polymerase Complex.
1. Cell - published August 3, 2019
2. Gilman MSA, Liu C, Fung A, Behera I, Jordan P, Rigaux P, Ysebaert N, Tcherniuk S, Sourimant J, Eléouët JF, Sutto-Ortiz P, Decroly E, Roymans D, Jin Z, McLellan JS
mkgridXf: Consistent Identification of Plausible Binding Sites Despite the Elusive Nature of Cavities and Grooves in Protein Dynamics.
1. J Chem Inf Model - published August 2, 2019
2. Monet D, Desdouits N, Nilges M, Blondel A
Carboxyboronate: A Versatile C1-Building Block.
1. Angew Chem Int Ed Engl - published August 2, 2019
2. Yudin AK, Holownia A, Tien CH, Diaz DB, Larson RT
Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose dehydratase.
1. J Biol Chem - published August 2, 2019
2. Eisemann T, Langelier MF, Pascal JM
HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope.
1. J Med Chem - published August 2, 2019
2. Rusere LN, Lockbaum GJ, Lee SK, Henes M, Kosovrasti K, Spielvogel E, Nalivaika EA, Swanstrom R, Yilmaz NK, Schiffer CA, Ali A
Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II.
1. J Med Chem - published August 2, 2019
2. Van Zandt MC, Jagdmann GE, Whitehouse DL, Ji M, Savoy J, Potapova O, Cousido-Siah A, Mitschler A, Howard EI, Pyle AM, Podjarny AD
Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA.
1. Nucleic Acids Res - published August 2, 2019
2. Solomon WC, Myint W, Hou S, Kanai T, Tripathi R, Kurt Yilmaz N, Schiffer CA, Matsuo H
A Novel Bromine-Containing Paroxetine Analogue Provides Mechanistic Clues for Binding Ambiguity at the Central Primary Binding Site of the Serotonin Transporter.
1. ACS Chem Neurosci - published August 2, 2019
2. Slack RD, Abramyan AM, Tang H, Meena S, Davis BA, Bonifazi A, Giancola JB, Deschamps JR, Naing S, Yano H, Singh SK, Newman AH, Shi L
Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence.
1. Elife - published August 2, 2019
2. Yu L, O'Brien VP, Livny J, Dorsey D, Bandyopadhyay N, Colonna M, Caparon MG, Roberson ED, Hultgren SJ, Hannan TJ
Probing the Robustness of Inhibitors of Tuberculosis Aminoglycoside Resistance Enzyme Eis by Mutagenesis.
1. ACS Infect Dis - published August 2, 2019
2. Green KD, Punetha A, Hou C, Garneau-Tsodikova S, Tsodikov OV
Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis.
1. Proc Natl Acad Sci U S A - published August 2, 2019
2. Nicoludis JM, Green AG, Walujkar S, May EJ, Sotomayor M, Marks DS, Gaudet R
Combining Mutations That Inhibit Two Distinct Steps of the ATP Hydrolysis Cycle Restores Wild-Type Function in the Lipopolysaccharide Transporter and Shows that ATP Binding Triggers Transport.
1. MBio - published August 2, 2019
2. Simpson BW, Pahil KS, Owens TW, Lundstedt EA, Davis RM, Kahne D, Ruiz N
The iron-regulated vacuolar Legionella pneumophila MavN protein is a transition-metal transporter.
1. Proc Natl Acad Sci U S A - published August 2, 2019
2. Christenson ET, Isaac DT, Yoshida K, Lipo E, Kim JS, Ghirlando R, Isberg RR, Banerjee A
Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown.
1. Proc Natl Acad Sci U S A - published August 2, 2019
2. Vecchio AJ, Stroud RM
Force-induced conformational changes in PIEZO1.
1. Nature - published August 2, 2019
2. Lin YC, Guo YR, Miyagi A, Levring J, MacKinnon R, Scheuring S
Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex.
1. Elife - published August 2, 2019
2. Uchikawa E, Choi E, Shang G, Yu H, Bai XC
Glycoprotein Ib clustering in platelets can be inhibited by alpha-linolenic acid as revealed by cryo-electron tomography.
1. Haematologica - published August 2, 2019
2. Stivala S, Sorrentino S, Gobbato S, Bonetti NR, Camici GG, Lüscher TF, Medalia O, Beer JH
Pre- and post-docking sampling of conformational changes using ClustENM and HADDOCK for protein-protein and protein-DNA systems.
1. Proteins - published August 2, 2019
2. Kurkcuoglu Z, Bonvin AMJJ
Target highlights in CASP13: experimental target structures through the eyes of their authors.
1. Proteins - published August 2, 2019
2. Lepore R, Kryshtafovych A, Alahuhta M, Arora Veraszto H, Bomble YJ, Bufton JC, Bullock AN, Caba C, Cao H, Davies OR, Desfosses A, Dunne M, Fidelis K, Goulding CW, Gurusaran M, Gutsche I, Harding CJ, Hartmann MD, Hayes CS, Joachimiak A, Leiman PG, Loppnau P, Lovering AL, Lunin VV, Michalska K, Mir-Sanchis I, Mitra A, Moult J, Phillips GN Jr, Pinkas DM, Rice PA, Tong Y, Topf M, Walton JD, Schwede T
Molecular evolution of the switch for progesterone and spironolactone from mineralocorticoid receptor agonist to antagonist.
1. Proc Natl Acad Sci U S A - published August 2, 2019
2. Fuller PJ, Yao YZ, Jin R, He S, Martín-Fernández B, Young MJ, Smith BJ
The structural details of the interaction of single-stranded DNA binding protein hSSB2 (NABP1/OBFC2A) with UV-damaged DNA.
1. Proteins - published August 2, 2019
2. Lawson T, El-Kamand S, Boucher D, Duong DC, Kariawasam R, Bonvin AMJJ, Richard DJ, Gamsjaeger R, Cubeddu L
Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation.
1. Science - published August 2, 2019
2. Kim TH, Tsang B, Vernon RM, Sonenberg N, Kay LE, Forman-Kay JD
PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing.
1. Nat Commun - published August 2, 2019
2. Wu X, Ivanchenko MV, Al Jandal H, Cicconet M, Indzhykulian AA, Corey DP
The Scs disulfide reductase system cooperates with the metallochaperone CueP in Salmonella copper resistance.
1. J Biol Chem - published August 2, 2019
2. Subedi P, Paxman JJ, Wang G, Ukuwela AA, Xiao Z, Heras B
Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin.
1. Sci Rep - published August 2, 2019
2. Pelc LA, Koester SK, Chen Z, Gistover NE, Di Cera E
Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission.
1. Cell Host Microbe - published August 2, 2019
2. Buffalo CZ, Stürzel CM, Heusinger E, Kmiec D, Kirchhoff F, Hurley JH, Ren X
Binding Site Location on GABAA Rs Determines Whether Mixtures of Intravenous General Anesthetics Interact Synergistically or Additively in vivo.
1. Br J Pharmacol - published August 2, 2019
2. Kent DE, Savechenkov PY, Bruzik KS, Miller KW
Mechanics and pharmacology of substrate selection and transport by eukaryotic ABC exporters.
1. Nat Struct Mol Biol - published August 2, 2019
2. Srikant S, Gaudet R
Genetic Mosaicism in Calmodulinopathy.
1. Circ Genom Precis Med - published August 2, 2019
2. Wren LM, Jiménez-Jáimez J, Al-Ghamdi S, Al-Aama JY, Bdeir A, Al-Hassnan ZN, Kuan JL, Foo RY, Potet F, Johnson CN, Aziz MC, Carvill GL, Kaski JP, Crotti L, Perin F, Monserrat L, Burridge PW, Schwartz PJ, Chazin WJ, Bhuiyan ZA, George AL Jr
Findings from home-based HIV testing and facilitated linkage after scale-up of test and treat in rural South Africa: young people still missing.
1. HIV Med - published August 2, 2019
2. Baisley KJ, Seeley J, Siedner MJ, Koole K, Matthews P, Tanser F, Bärnighausen T, Smit T, Gareta D, Dlamini S, Herbst K, Hm Y, Cc I, Hy K, D P, M S
Robust suppression of lipopolysaccharide deficiency in Acinetobacter baumannii by growth in minimal medium.
1. J Bacteriol - published August 2, 2019
2. Nagy E, Losick R, Kahne D
Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.
1. Cell Rep - published August 2, 2019
2. Chatterjee N, Pazarentzos E, Mayekar MK, Gui P, Allegakoen DV, Hrustanovic G, Olivas V, Lin L, Verschueren E, Johnson JR, Hofree M, Yan JJ, Newton BW, Dollen JV, Earnshaw CH, Flanagan J, Chan E, Asthana S, Ideker T, Wu W, Suzuki J, Barad BA, Kirichok Y, Fraser JS, Weiss WA, Krogan NJ, Tulpule A, Sabnis AJ, Bivona TG
Stimuli-Responsive Lyotropic Liquid Crystalline Nanosystems with Incorporated Poly(2-Dimethylamino Ethyl Methacrylate)-b-Poly(Lauryl Methacrylate) Amphiphilic Block Copolymer.
1. Polymers (Basel) - published August 2, 2019
2. Chountoulesi M, Pippa N, Chrysostomou V, Pispas S, Chrysina ED, Forys A, Otulakowski L, Trzebicka B, Demetzos C
Crystal Structure of African Swine Fever Virus A179L with the Autophagy Regulator Beclin.
1. Viruses - published August 2, 2019
2. Banjara S, Shimmon GL, Dixon LK, Netherton CL, Hinds MG, Kvansakul M
A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex.
1. Elife - published August 2, 2019
2. Partlow EA, Baker RW, Beacham GM, Chappie JS, Leschziner AE, Hollopeter G
Chemical tools to characterize peptidoglycan synthases.
1. Curr Opin Chem Biol - published August 2, 2019
2. Taguchi A, Kahne D, Walker S
Antibodies against Plasmodium falciparum malaria at the molecular level.
1. Nat Rev Immunol - published August 2, 2019
2. Julien JP, Wardemann H
DNA damage response mechanisms and structures fundamental to cancer research progress.
1. Prog Biophys Mol Biol - published August 2, 2019
2. Bacolla A, Tainer JA
Recent Insights from Molecular Dynamics Simulations for G Protein-Coupled Receptor Drug Discovery.
1. Int J Mol Sci - published August 2, 2019
2. Zou Y, Ewalt J, Ng HL
Safety and pharmacokinetics of broadly neutralising human monoclonal antibody VRC07-523LS in healthy adults: a phase 1 dose-escalation clinical trial.
1. Lancet HIV - published August 2, 2019
2. Gaudinski MR, Houser KV, Doria-Rose NA, Chen GL, Rothwell RSS, Berkowitz N, Costner P, Holman LA, Gordon IJ, Hendel CS, Kaltovich F, Conan-Cibotti M, Gomez Lorenzo M, Carter C, Sitar S, Carlton K, Gall J, Laurencot C, Lin BC, Bailer RT, McDermott AB, Ko SY, Pegu A, Kwon YD, Kwong PD, Namboodiri AM, Pandey JP, Schwartz R, Arnold F, Hu Z, Zhang L, Huang Y, Koup RA, Capparelli EV, Graham BS, Mascola JR, Ledgerwood JE, VRC 605 study team.
A Structure-Informed Atlas of Human-Virus Interactions.
1. Cell - published August 2, 2019
2. Lasso G, Mayer SV, Winkelmann ER, Chu T, Elliot O, Patino-Galindo JA, Park K, Rabadan R, Honig B, Shapira SD
The impact of natural selection on the evolution and function of placentally expressed galectins.
1. Genome Biol Evol - published August 2, 2019
2. Ely ZA, Moon JM, Sliwoski GR, Sangha AK, Shen XX, Labella AL, Meiler J, Capra JA, Rokas A
pCRM1exportome: database of predicted CRM1-dependent Nuclear Export Signal (NES) motifs in cancer-related genes.
1. Bioinformatics - published August 2, 2019
2. Lee Y, Baumhardt JM, Pei J, Chook YM, Grishin NV
Dual Arms of Adaptive Immunity: Division of Labor and Collaboration between B and T Cells.
1. Cell - published August 2, 2019
2. Garcia KC
Proteomics-Based Monitoring of Pathway Activity Reveals that Blocking Diacylglycerol Biosynthesis Rescues from Alpha-Synuclein Toxicity.
1. Cell Syst - published August 2, 2019
2. Soste M, Charmpi K, Lampert F, Gerez JA, van Oostrum M, Malinovska L, Boersema PJ, Prymaczok NC, Riek R, Peter M, Vanni S, Beyer A, Picotti P
20-HETE synthesis inhibition promotes cerebral protection after intracerebral hemorrhage without inhibiting angiogenesis.
1. J Cereb Blood Flow Metab - published August 1, 2019
2. Han X, Zhao X, Lan X, Li Q, Gao Y, Liu X, Wan J, Yang Z, Chen X, Zang W, Guo AM, Falck JR, Koehler RC, Wang J
Inhibition of AKT signalling by benzoxazine derivative LTUR6 through the modulation of downstream kinases.
1. Invest New Drugs - published August 1, 2019
2. Suraj R, Al-Rawi J, Bradley C
Introduction to a special issue on Frontiers of Aberration Corrected Electron Microscopy in honour of Christian Colliex, Archie Howie and Hannes Lichte on the occasion of their 75th, 85th and 75th birthdays.
1. Ultramicroscopy - published August 1, 2019
2. Dunin-Borkowski RE, Mayer J, Sachse C, Tillmann K
Updates on the epigenetic roles of sirtuins.
1. Curr Opin Chem Biol - published August 1, 2019
2. Kosciuk T, Wang M, Hong JY, Lin H
C9orf72 and triplet repeat disorder RNAs: G-quadruplex formation, binding to PRC2 and implications for disease mechanisms.
1. RNA - published August 1, 2019
2. Wang X, Goodrich KJ, Conlon EG, Gao J, Erbse AH, Manley JL, Cech TR
A de novo substitution in BCL11B leads to loss of interaction with transcriptional complexes and craniosynostosis.
1. Hum Mol Genet - published August 1, 2019
2. Goos JAC, Vogel WK, Mlcochova H, Millard CJ, Esfandiari E, Selman WH, Calpena E, Koelling N, Carpenter EL, Swagemakers SMA, van der Spek PJ, Filtz TM, Schwabe JWR, Iwaniec UT, Mathijssen IMJ, Leid M, Twigg SRF
Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome.
1. Bone - published August 1, 2019
2. Gordon CM, Cleveland RH, Baltrusaitis K, Massaro J, D'Agostino RB Sr, Liang MG, Snyder B, Walters M, Li X, Braddock DT, Kleinman ME, Kieran MW, Gordon LB
Ligand retargeting by binding site analogy.
1. Eur J Med Chem - published August 1, 2019
2. Wiedmer L, Schärer C, Spiliotopoulos D, Hürzeler M, Śledź P, Caflisch A
An evolutionary perspective on the first disulfide bond in members of the cholinesterase-carboxylesterase (COesterase) family: Possible outcomes for cholinesterase expression in prokaryotes.
1. Chem Biol Interact - published August 1, 2019
2. Chatonnet A, Brazzolotto X, Hotelier T, Lenfant N, Marchot P, Bourne Y
Targeted delivery and endosomal cellular uptake of DARPin-siRNA bioconjugates: Influence of linker stability on gene silencing.
1. Eur J Pharm Biopharm - published August 1, 2019
2. Lorenzer C, Streußnig S, Tot E, Winkler AM, Merten H, Brandl F, Sayers EJ, Watson P, Jones AT, Zangemeister-Wittke U, Plückthun A, Winkler J
EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer.
1. Mol Cancer Ther - published August 1, 2019
2. Viswanadhapalli S, Luo Y, Sareddy GR, Santhamma B, Zhou M, Li M, Ma S, Sonavane R, Pratap UP, Altwegg KA, Li X, Chang A, Chávez-Riveros A, Dileep KV, Zhang KYJ, Pan X, Murali R, Bajda M, Raj GV, Brenner AJ, Manthati V, Rao MK, Tekmal RR, Nair HB, Nickisch KJ, Vadlamudi RK
Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases.
1. Nat Chem Biol - published August 1, 2019
2. Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE
Localized Electronic Structure of Nitrogenase FeMoco Revealed by Selenium K-Edge High Resolution X-ray Absorption Spectroscopy.
1. J Am Chem Soc - published August 1, 2019
2. Henthorn JT, Arias RJ, Koroidov S, Kroll T, Sokaras D, Bergmann U, Rees DC, DeBeer S
Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance.
1. ACS Chem Biol - published August 1, 2019
2. Henes M, Lockbaum GJ, Kosovrasti K, Leidner F, Nachum GS, Nalivaika EA, Lee SK, Spielvogel E, Zhou S, Swanstrom R, Bolon DNA, Kurt Yilmaz N, Schiffer CA
In vitro 0N4R tau fibrils contain a monomorphic β-sheet core enclosed by dynamically heterogeneous fuzzy coat segments.
1. Proc Natl Acad Sci U S A - published August 1, 2019
2. Dregni AJ, Mandala VS, Wu H, Elkins MR, Wang HK, Hung I, DeGrado WF, Hong M
Systems NMR: single-sample quantification of RNA, proteins and metabolites for biomolecular network analysis.
1. Nat Methods - published August 1, 2019
2. Nikolaev Y, Ripin N, Soste M, Picotti P, Iber D, Allain FH
Open and cut: allosteric motion and membrane fission by dynamin superfamily proteins.
1. Mol Biol Cell - published August 1, 2019
2. Kalia R, Frost A
The Novel Interaction Between Neisseria gonorrhoeae TdfJ and Human S100A7 Allows Gonococci to Subvert Host Zinc Restriction.
1. PLoS Pathog - published August 1, 2019
2. Maurakis S, Keller K, Maxwell CN, Pereira K, Chazin WJ, Criss AK, Cornelissen CN
A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors.
1. ACS Chem Biol - published August 1, 2019
2. Hong JY, Price IR, Bai JJ, Lin H
CRISPR Tools for Systematic Studies of RNA Regulation.
1. Cold Spring Harb Perspect Biol - published August 1, 2019
2. Engreitz J, Abudayyeh O, Gootenberg J, Zhang F
Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations.
1. Nat Commun - published August 1, 2019
2. de Wispelaere M, Du G, Donovan KA, Zhang T, Eleuteri NA, Yuan JC, Kalabathula J, Nowak RP, Fischer ES, Gray NS, Yang PL
Comparison of structural progression between ciliopathy and non-ciliopathy associated with autosomal recessive retinitis pigmentosa.
1. Orphanet J Rare Dis - published August 1, 2019
2. Takahashi VKL, Xu CL, Takiuti JT, Apatoff MBL, Duong JK, Mahajan VB, Tsang SH
Disruption of IRE1α through its kinase domain attenuates multiple myeloma.
1. Proc Natl Acad Sci U S A - published August 1, 2019
2. Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen YA, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, Clark K, Kaufman S, Beresini MH, Laing ST, Sandoval W, Lorenzo M, Wu J, Ly J, De Bruyn T, Heidersbach A, Haley B, Gogineni A, Weimer RM, Lee D, Braun MG, Rudolph J, VanWyngarden MJ, Sherbenou DW, Gomez-Bougie P, Amiot M, Acosta-Alvear D, Walter P, Ashkenazi A
Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints.
1. J Chem Inf Model - published August 1, 2019
2. Leidner F, Kurt Yilmaz N, Schiffer CA
The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.
1. Nat Struct Mol Biol - published August 1, 2019
2. Batki J, Schnabl J, Wang J, Handler D, Andreev VI, Stieger CE, Novatchkova M, Lampersberger L, Kauneckaite K, Xie W, Mechtler K, Patel DJ, Brennecke J
Direction of Chain Growth and Substrate Preferences of Shape, Elongation, Division, and Sporulation-Family Peptidoglycan Glycosyltransferases.
1. J Am Chem Soc - published August 1, 2019
2. Welsh MA, Schaefer K, Taguchi A, Kahne D, Walker S
Co-crystal structure of the iMango-III fluorescent RNA aptamer using an X-ray free-electron laser.
1. Acta Crystallogr F Struct Biol Commun - published August 1, 2019
2. Trachman RJ 3rd, Stagno JR, Conrad C, Jones CP, Fischer P, Meents A, Wang YX, Ferré-D'Amaré AR
Crystal structure of the Schizosaccharomyces pombe U7BR E2-binding region in complex with Ubc7.
1. Acta Crystallogr F Struct Biol Commun - published August 1, 2019
2. Hann ZS, Metzger MB, Weissman AM, Lima CD
Structural characterization of Class 2 OLD family nucleases supports a two-metal catalysis mechanism for cleavage.
1. Nucleic Acids Res - published August 1, 2019
2. Schiltz CJ, Lee A, Partlow EA, Hosford CJ, Chappie JS
A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary CaVβ subunits.
1. Elife - published August 1, 2019
2. Morgenstern T, Park J, Fan QR, Colecraft HM
CAPN5 genetic inactivation phenotype supports therapeutic inhibition trials.
1. Hum Mutat - published August 1, 2019
2. Wert KJ, Koch SF, Velez G, Hsu CW, Mahajan M, Bassuk AG, Tsang SH, Mahajan VB
Roles of HIFs and VEGF in angiogenesis in the retina and brain.
1. J Clin Invest - published August 1, 2019
2. Rattner A, Williams J, Nathans J
Structure and chemistry of lysinoalanine crosslinking in the spirochaete flagella hook.
1. Nat Chem Biol - published August 1, 2019
2. Lynch MJ, Miller M, James M, Zhang S, Zhang K, Li C, Charon NW, Crane BR
Plasma deconvolution identifies broadly neutralizing antibodies associated with hepatitis C virus clearance.
1. J Clin Invest - published August 1, 2019
2. Kinchen VJ, Massaccesi G, Flyak AI, Mankowski MC, Colbert MD, Osburn WO, Ray SC, Cox AL, Crowe JE Jr, Bailey JR
Structural characterization of the human membrane protein VDAC2 in lipid bilayers by MAS NMR.
1. J Biomol NMR - published August 1, 2019
2. Eddy MT, Yu TY, Wagner G, Griffin RG
Conformational Control of Macrocycles by Remote Structural Modification.
1. Chem Rev - published August 1, 2019
2. Appavoo SD, Huh S, Diaz DB, Yudin AK
Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus.
1. mBio - published August 1, 2019
2. Baggen J, Thibaut HJ, Hurdiss DL, Wahedi M, Marceau CD, van Vliet ALW, Carette JE, van Kuppeveld FJM
Lipid Droplets Grease Enterovirus Replication.
1. Cell Host Microbe - published August 1, 2019
2. Belov GA, van Kuppeveld FJM
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.
1. Sci Transl Med - published August 1, 2019
2. Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, Li Z, Del-Aguila JL, Dube U, Farias FG, Bradley J, Budde J, Ibanez L, Fernandez MV, Blennow K, Zetterberg H, Heslegrave A, Johansson PM, Svensson J, Nellgård B, Lleo A, Alcolea D, Clarimon J, Rami L, Molinuevo JL, Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Ewers M, Harari O, Haass C, Brett TJ, Benitez BA, Karch CM, Piccio L, Cruchaga C
Ega3 from the fungal pathogen Aspergillus fumigatus is an endo-α-1,4-galactosaminidase that disrupts microbialbiofilms.
1. J Biol Chem - published August 1, 2019
2. Bamford NC, Le Mauff F, Subramanian AS, Yip P, Millán C, Zhang Y, Zacharias C, Forman A, Nitz M, Codée JDC, Usón I, Sheppard DC, Howell PL
Radiological and clinical predictors of scoliosis in patients with Chiari malformation type I and spinal cord syrinx from the Park-Reeves Syringomyelia Research Consortium.
1. J Neurosurg Pediatr - published August 1, 2019
2. Strahle JM, Taiwo R, Averill C, Torner J, Shannon CN, Bonfield CM, Tuite GF, Bethel-Anderson T, Rutlin J, Brockmeyer DL, Wellons JC, Leonard JR, Mangano FT, Johnston JM, Shah MN, Iskandar BJ, Tyler-Kabara EC, Daniels DJ, Jackson EM, Grant GA, Couture DE, Adelson PD, Alden TD, Aldana PR, Anderson RCE, Selden NR, Baird LC, Bierbrauer K, Chern JJ, Whitehead WE, Ellenbogen RG, Fuchs HE, Guillaume DJ, Hankinson TC, Iantosca MR, Oakes WJ, Keating RF, Khan NR, Muhlbauer MS, McComb JG, Menezes AH, Ragheb J, Smith JL, Maher CO, Greene S, Kelly M, O'Neill BR, Krieger MD, Tamber M, Durham SR, Olavarria G, Stone SSD, Kaufman BA, Heuer GG, Bauer DF, Albert G, Greenfield JP, Wait SD, Van Poppel MD, Eskandari R, Mapstone T, Shimony JS, Dacey RG, Smyth MD, Park TS, Limbrick DD
Conformationally stable peptide macrocycles assembled using the Petasis borono-Mannich reaction.
1. Chem Commun (Camb) - published August 1, 2019
2. Yamaguchi A, Kaldas SJ, Appavoo SD, Diaz DB, Yudin AK
The impact of electrical injuries on long-term outcomes: A Burn Model System National Database study.
1. Burns - published August 1, 2019
2. Or S, Aw W, Lf E, Lc S, K K, Gj C, N G, Am B, W M, M R, L R, LE K, Cm R, Jc S
Ca2+-regulated Ca2+ channels with an RCK gating ring control plant symbiotic associations.
1. Nat Commun - published August 1, 2019
2. Kim S, Zeng W, Bernard S, Liao J, Venkateshwaran M, Ane JM, Jiang Y
Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways.
1. J Cell Biol - published August 1, 2019
2. Azoitei ML, Noh J, Marston DJ, Roudot P, Marshall CB, Daugird TA, Lisanza SL, Sandí MJ, Ikura M, Sondek J, Rottapel R, Hahn KM, Danuser G
Structure of the Centromere Binding Factor 3 Complex from Kluyveromyces lactis.
1. J Mol Biol - published August 1, 2019
2. Lee PD, Wei H, Tan D, Harrison SC
Tracking RNA with light: selection, structure, and design of fluorescence turn-on RNA aptamers.
1. Q Rev Biophys - published August 1, 2019
2. Trachman RJ, Ferré-D'Amaré AR
Qualitative Analyses of Polishing and Precoating FIB Milled Crystals for MicroED.
1. Structure - published August 1, 2019
2. Martynowycz MW, Zhao W, Hattne J, Jensen GJ, Gonen T
Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice.
1. Nat Biotechnol - published August 1, 2019
2. Mourtada R, Herce HD, Yin DJ, Moroco JA, Wales TE, Engen JR, Walensky LD
Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway.
1. Mol Cell - published August 1, 2019
2. Uroda T, Anastasakou E, Rossi A, Teulon JM, Pellequer JL, Annibale P, Pessey O, Inga A, Chillón I, Marcia M
Further Evidence that the Soluble Urokinase Plasminogen Activator Receptor Does Not Directly Injure Mice or Human Podocytes.
1. Transplantation - published August 1, 2019
2. Harel E, Shoji J, Abraham V, Miller L, Laszik ZG, King A, Dobi D, Szabo G, Hann B, Sarwal MM, Craik CS, Vincenti F
Structures of Respiratory Supercomplex I+III2 Reveal Functional and Conformational Crosstalk.
1. Mol Cell - published August 1, 2019
2. Letts JA, Fiedorczuk K, Degliesposti G, Skehel M, Sazanov LA