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140 Member Publications for April 2019

N-Linked Glycosylation Regulates CD22 Organization and Function.
1. Front Immunol - published April 26, 2019
2. Wasim L, Buhari FHM, Yoganathan M, Sicard T, Ereño-Orbea J, Julien JP, Treanor B
Pore timing: the evolutionary origins of the nucleus and nuclear pore complex.
1. F1000Res - published April 20, 2019
2. Field MC, Rout MP
Signal-induced PARP1-Erk synergism mediates IEG expression.
1. Signal Transduct Target Ther - published April 18, 2019
2. Cohen-Armon M, Yeheskel A, Pascal JM
Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting.
1. PLoS One - published April 18, 2019
2. Cheng C, Xu K, Kong R, Chuang GY, Corrigan AR, Geng H, Hill KR, Jafari AJ, O'Dell S, Ou L, Rawi R, Rowshan AP, Sarfo EK, Sastry M, Saunders KO, Schmidt SD, Wang S, Wu W, Zhang B, Doria-Rose NA, Haynes BF, Scorpio DG, Shapiro L, Mascola JR, Kwong PD
ETDB-Caltech: A blockchain-based distributed public database for electron tomography.
1. PLoS One - published April 16, 2019
2. Ortega DR, Oikonomou CM, Ding HJ, Rees-Lee P, Alexandria., Jensen GJ
Structural Diversity of Ultralong CDRH3s in Seven Bovine Antibody Heavy Chains.
1. Front Immunol - published April 11, 2019
2. Dong J, Finn JA, Larsen PA, Smith TPL, Crowe JE Jr
Crystal structure of the SH3 domain of human Lyn non-receptor tyrosine kinase.
1. PLoS One - published April 11, 2019
2. Berndt S, Gurevich VV, Iverson TM
Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration.
1. Elife - published April 9, 2019
2. Hallberg ZF, Chan CH, Wright TA, Kranzusch PJ, Doxzen KW, Park JJ, Bond DR, Hammond MC
A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex.
1. Cell Rep - published April 9, 2019
2. Marabelli C, Marrocco B, Pilotto S, Chittori S, Picaud S, Marchese S, Ciossani G, Forneris F, Filippakopoulos P, Schoehn G, Rhodes D, Subramaniam S, Mattevi A
Chromatin fiber structural motifs as regulatory hubs of genome function?
1. Essays Biochem - published April 9, 2019
2. Moraru M, Schalch T
Human mAbs to Staphylococcus aureus IsdA Provide Protection Through Both Heme-Blocking and Fc-Mediated Mechanisms.
1. J Infect Dis - published April 8, 2019
2. Bennett MR, Bombardi RG, Kose N, Parrish EH, Nagel MB, Petit RA, Read TD, Schey KL, Thomsen IP, Skaar EP, Crowe JE
Antibody Determinants of Influenza Immunity.
1. J Infect Dis - published April 8, 2019
2. Crowe JE
Structural studies reveal the enantiospecific recognition of a DNA G-quadruplex by a ruthenium polypyridyl complex.
1. Angew Chem Int Ed Engl - published April 8, 2019
2. McQuaid K, Abell H, Gurung SP, Allan D, Winter G, Sorensen T, Cardin DJ, Brazier JA, Cardin CJ, Hall JP
GNAS: A New Nephrogenic Cause of Inappropriate Antidiuresis.
1. J Am Soc Nephrol - published April 8, 2019
2. Bichet DG, Granier S, Bockenhauer D
Cryo-EM-On-a-Chip: Custom-Designed Substrates for the 3D Analysis of Macromolecules.
1. Small - published April 8, 2019
2. Alden NA, Varano AC, Dearnaley WJ, Solares MJ, Luqiu WY, Liang Y, Sheng Z, McDonald SM, Damiano J, McConnell J, Dukes MJ, Kelly DF
Publisher Correction: Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus.
1. Nat Microbiol - published April 8, 2019
2. Kraemer MUG, Reiner RC Jr, Brady OJ, Messina JP, Gilbert M, Pigott DM, Yi D, Johnson K, Earl L, Marczak LB, Shirude S, Weaver ND, Bisanzio D, Perkins TA, Lai S, Lu X, Jones P, Coelho GE, Carvalho RG, Van Bortel W, Marsboom C, Hendrickx G, Schaffner F, Moore CG, Nax HH, Bengtsson L, Wetter E, Tatem AJ, Brownstein JS, Smith DL, Lambrechts L, Cauchemez S, Linard C, Faria NR, Pybus OG, Scott TW, Liu Q, Yu H, Wint GRW, Hay SI, Golding N
Structural features underlying recognition and translocation of extracellular polysaccharides.
1. Interface Focus - published April 6, 2019
2. Zimmer J
Deposition of Host Matrix Proteins on Breast Implant Surfaces Facilitates Staphylococcus Epidermidis Biofilm Formation: In Vitro Analysis.
1. Aesthet Surg J - published April 6, 2019
2. Walker JN, Pinkner CL, Lynch AJL, Ortbal S, Pinkner JS, Hultgren SJ, Myckatyn TM
Phylogenetic Analysis with Improved Parameters Reveals Conservation in lncRNA Structures.
1. J Mol Biol - published April 5, 2019
2. Tavares RCA, Pyle AM, Somarowthu S
Utility of macrophages in an antitumor strategy based on the vectorization of iron oxide nanoparticles.
1. Nanoscale - published April 5, 2019
2. Dalzon B, Guidetti M, Testemale D, Reymond S, Proux O, Vollaire J, Collin-Faure V, Testard I, Fenel D, Schoehn G, Arnaud J, Carrière M, Josserand V, Rabilloud T, Aude-Garcia C
ATG2 transports lipids to promote autophagosome biogenesis.
1. J Cell Biol - published April 5, 2019
2. Valverde DP, Yu S, Boggavarapu V, Kumar N, Lees JA, Walz T, Reinisch KM, Melia TJ
Tissue-specific oncogenic activity of K-RasA146T.
1. Cancer Discov - published April 5, 2019
2. Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM
Structural basis for selectivity in flavin-dependent monooxygenase-catalyzed oxidative dearomatization.
1. ACS Catal - published April 5, 2019
2. Benítez AR, Tweedy S, Baker Dockrey SA, Lukowski AL, Wymore T, Khare D, Brooks CL 3rd, Palfey BA, Smith JL, Narayan ARH
Physical Basis for the Loading of a Bacterial Replicative Helicase onto DNA.
1. Mol Cell - published April 4, 2019
2. Arias-Palomo E, Puri N, O'Shea Murray VL, Yan Q, Berger JM
Cryo-EM Analysis Reveals Structural Basis of Helicobacter pylori VacA Toxin Oligomerization.
1. J Mol Biol - published April 4, 2019
2. Su M, Erwin AL, Campbell AM, Pyburn TM, Salay LE, Hanks JL, Lacy DB, Akey DL, Cover TL, Ohi MD
Immunization with Components of the Viral Fusion Apparatus Elicits Antibodies That Neutralize Epstein-Barr Virus in B Cells and Epithelial Cells.
1. Immunity - published April 4, 2019
2. Bu W, Joyce MG, Nguyen H, Banh DV, Aguilar F, Tariq Z, Yap ML, Tsujimura Y, Gillespie RA, Tsybovsky Y, Andrews SF, Narpala SR, McDermott AB, Rossmann MG, Yasutomi Y, Nabel GJ, Kanekiyo M, Cohen JI
Cigarette Smoking among Economically Disadvantaged African-American Older Adults in South Los Angeles: Gender Differences.
1. Int J Environ Res Public Health - published April 4, 2019
2. Assari S, Smith JL, Zimmerman MA, Bazargan M
A Small-Molecule SIRT2 Inhibitor That Promotes K-Ras4a Lysine Fatty-Acylation.
1. ChemMedChem - published April 3, 2019
2. Spiegelman NA, Hong JY, Hu J, Jing H, Wang M, Price IR, Cao J, Yang M, Zhang X, Lin H
Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein.
1. Emerg Microbes Infect - published April 3, 2019
2. Widjaja I, Wang C, van Haperen R, Gutiérrez-Álvarez J, van Dieren B, Okba NMA, Raj VS, Li W, Fernandez-Delgado R, Grosveld F, van Kuppeveld FJM, Haagmans BL, Enjuanes L, Drabek D, Bosch BJ
Variation in assembly stoichiometry in non-metazoan homologs of the hub domain of Ca2+/Calmodulin-dependent protein kinase II.
1. Protein Sci - published April 3, 2019
2. McSpadden ED, Xia Z, Chi CC, Susa AC, Shah NH, Gee CL, Williams ER, Kuriyan J
Effects of the SOS (A501C/T605C) and DS (I201C/A433C) Disulfide Bonds on HIV-1 Membrane Envelope Glycoprotein Conformation and Function.
1. J Virol - published April 3, 2019
2. Nguyen HT, Alsahafi N, Finzi A, Sodroski JG
Identification and Characterization of Functional Human Monoclonal Antibodies to Plasmodium vivax Duffy-Binding Protein.
1. J Immunol - published April 3, 2019
2. Carias LL, Dechavanne S, Nicolete VC, Sreng S, Suon S, Amaratunga C, Fairhurst RM, Dechavanne C, Barnes S, Witkowski B, Popovici J, Roesch C, Chen E, Ferreira MU, Tolia NH, Adams JH, King CL
Author Correction: CasX enzymes comprise a distinct family of RNA-guided genome editors.
1. Nature - published April 3, 2019
2. Liu JJ, Orlova N, Oakes BL, Ma E, Spinner HB, Baney KLM, Chuck J, Tan D, Knott GJ, Harrington LB, Al-Shayeb B, Wagner A, Brötzmann J, Staahl BT, Taylor KL, Desmarais J, Nogales E, Doudna JA
Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.
1. Proc Natl Acad Sci U S A - published April 3, 2019
2. Kuzina ES, Ung PM, Mohanty J, Tome F, Choi J, Pardon E, Steyaert J, Lax I, Schlessinger A, Schlessinger J, Lee S
Ca²⁺-dependent regulation of sodium channels Na_V1.4 and Na_V1.5 is controlled by the post-IQ motif.
1. Nat Commun - published April 3, 2019
2. Yoder JB, Ben-Johny M, Farinelli F, Srinivasan L, Shoemaker SR, Tomaselli GF, Gabelli SB, Amzel LM
Structural insight into TRPV5 channel function and modulation.
1. Proc Natl Acad Sci U S A - published April 3, 2019
2. Dang S, van Goor MK, Asarnow D, Wang Y, Julius D, Cheng Y, van der Wijst J
Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution.
1. Proc Natl Acad Sci U S A - published April 3, 2019
2. Heng JS, Rattner A, Stein-O'Brien GL, Winer BL, Jones BW, Vernon HJ, Goff LA, Nathans J
Publisher Correction: Unusual substrate and halide versatility of phenolic halogenase PltM.
1. Nat Commun - published April 3, 2019
2. Mori S, Pang AH, Chandrika NT, Garneau-Tsodikova S, Tsodikov OV
Selective isotope labeling for NMR structure determination of proteins in complex with unlabeled ligands.
1. J Biomol NMR - published April 3, 2019
2. Tripsianes K, Schütz U, Emmanouilidis L, Gemmecker G, Sattler M
Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming.
1. Cell Syst - published April 3, 2019
2. Wang H, Sheehan RP, Palmer AC, Everley RA, Boswell SA, Ron-Harel N, Ringel AE, Holton KM, Jacobson CA, Erickson AR, Maliszewski L, Haigis MC, Sorger PK
Double-Stranded RNA Sensors and Modulators in Innate Immunity.
1. Annu Rev Immunol - published April 2, 2019
2. Hur S
De Novo Structural Pattern Mining in Cellular Electron Cryotomograms.
1. Structure - published April 2, 2019
2. Xu M, Singla J, Tocheva EI, Chang YW, Stevens RC, Jensen GJ, Alber F
Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase.
1. Proc Natl Acad Sci U S A - published April 2, 2019
2. Debarnot C, Monneau YR, Roig-Zamboni V, Delauzun V, Le Narvor C, Richard E, Hénault J, Goulet A, Fadel F, Vivès RR, Priem B, Bonnaffé D, Lortat-Jacob H, Bourne Y
Holo-like and Druggable Protein Conformations from Enhanced Sampling of Binding Pocket Volume and Shape.
1. J Chem Inf Model - published April 2, 2019
2. Basciu A, Malloci G, Pietrucci F, Bonvin AMJJ, Vargiu AV
Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin.
1. J Phys Chem B - published April 2, 2019
2. Moseng MA, Nix JC, Page RC
Disrupting Membrane Adaptation Restores In Vivo Efficacy of Antibiotics Against Multidrug-Resistant Enterococci and Potentiates Killing by Human Neutrophils.
1. J Infect Dis - published April 2, 2019
2. Rincon S, Panesso D, Miller WR, Singh KV, Cruz MR, Khan A, Dinh AQ, Diaz L, Rios R, Shamoo Y, Reyes J, Tran TT, Garsin DA, Arias CA
Myxoma virus M013 protein antagonizes NF-κB and inflammasome pathways via distinct structural motifs.
1. J Biol Chem - published April 2, 2019
2. Garg RR, Jackson CB, Rahman MM, Khan AR, Lewin AS, McFadden G
Caught in the Open: A Domain Insertion of M. tuberculosis Gyrase Suppresses ATPase Dimerization.
1. Structure - published April 2, 2019
2. Hobson MJ, Berger JM
Ubiquitin Variant Inhibitors Meet the Deubiquitinase USP15.
1. Structure - published April 2, 2019
2. Middleton AJ, Day CL
Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure.
1. Nat Commun - published April 2, 2019
2. Connelly CM, Numata T, Boer RE, Moon MH, Sinniah RS, Barchi JJ, Ferré-D'Amaré AR, Schneekloth JS Jr
Synthesis and application of the blue fluorescent amino acid l-4-cyanotryptophan to assess peptide-membrane interactions.
1. Chem Commun (Camb) - published April 2, 2019
2. Zhang K, Ahmed IA, Kratochvil HT, DeGrado WF, Gai F, Jo H
Function and solution structure of the Arabidopsis thaliana RALF8 peptide.
1. Protein Sci - published April 2, 2019
2. Frederick RO, Haruta M, Tonelli M, Lee W, Cornilescu G, Cornilescu CC, Sussman MR, Markley JL
Engineered peptide barcodes for in-depth analyses of binding protein libraries.
1. Nat Methods - published April 2, 2019
2. Egloff P, Zimmermann I, Arnold FM, Hutter CAJ, Morger D, Opitz L, Poveda L, Keserue HA, Panse C, Roschitzki B, Seeger MA
A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins.
1. Nat Commun - published April 2, 2019
2. Meksiriporn B, Ludwicki MB, Stephens EA, Jiang A, Lee HC, Waraho-Zhmayev D, Kummer L, Brandl F, Plückthun A, DeLisa MP
From fluorescent proteins to fluorogenic RNAs: tools for imaging cellular macromolecules.
1. Protein Sci - published April 2, 2019
2. Truong L, Ferré-D'Amaré AR
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation.
1. Cell Rep - published April 2, 2019
2. de Oliveira Mann CC, Orzalli MH, King DS, Kagan JC, Lee ASY, Kranzusch PJ
Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor.
1. Proc Natl Acad Sci U S A - published April 2, 2019
2. Mognol GP, González-Avalos E, Ghosh S, Spreafico R, Gudlur A, Rao A, Damoiseaux R, Hogan PG
Naturally processed HLA-DR3-restricted HHV-6b peptides are recognized broadly with polyfunctional and cytotoxic CD4 T cell responses.
1. Eur J Immunol - published April 2, 2019
2. Becerra-Artiles A, Cruz J, Leszyk JD, Sidney J, Sette A, Shaffer SA, Stern LJ
Tmem178 negatively regulates store-operated calcium entry in myeloid cells via association with STIM1.
1. J Autoimmun - published April 2, 2019
2. Yang Z, Yan H, Dai W, Jing J, Yang Y, Mahajan S, Zhou Y, Li W, Macaubas C, Mellins ED, Shih CC, Fitzpatrick JAJ, Faccio R
The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein.
1. Science - published April 2, 2019
2. Qi C, Sorrentino S, Medalia O, Korkhov VM
Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants.
1. J Mol Biol - published April 2, 2019
2. Ostertag MS, Hutwelker W, Plettenburg O, Sattler M, Popowicz GM
Author Correction: Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis.
1. Nat Commun - published April 2, 2019
2. Fotiou E, Martin-Almedina S, Simpson MA, Lin S, Gordon K, Brice G, Atton G, Jeffery I, Rees DC, Mignot C, Vogt J, Homfray T, Snyder MP, Rockson SG, Jeffery S, Mortimer PS, Mansour S, Ostergaard P
ABA/ASB structural biology session II 2018.
1. Biophys Rev - published April 2, 2019
2. Kvansakul M
Molluscum contagiosum virus MC80 sabotages MHC-I antigen presentation by targeting tapasin for ER-associated degradation.
1. PLoS Pathog - published April 2, 2019
2. Harvey IB, Wang X, Fremont DH
Structural prerequisites for CRM1-dependent nuclear export signaling peptides: accessibility, adapting conformation, and the stability at the binding site.
1. Sci Rep - published April 2, 2019
2. Lee Y, Pei J, Baumhardt JM, Chook YM, Grishin NV
Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9.
1. Nat Commun - published April 2, 2019
2. Hirano S, Abudayyeh OO, Gootenberg JS, Horii T, Ishitani R, Hatada I, Zhang F, Nishimasu H, Nureki O
Unique structural features of a bacterial autotransporter adhesin suggest mechanisms for interaction with host macromolecules.
1. Nat Commun - published April 2, 2019
2. Paxman JJ, Lo AW, Sullivan MJ, Panjikar S, Kuiper M, Whitten AE, Wang G, Luan CH, Moriel DG, Tan L, Peters KM, Phan MD, Gee CL, Ulett GC, Schembri MA, Heras B
The essential role of hypermutation in rapid adaptation to antibiotic stress.
1. Antimicrob Agents Chemother - published April 2, 2019
2. Mehta HH, Prater AG, Beabout K, Elworth RAL, Karavis M, Gibbons HS, Shamoo Y
Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics.
1. ACS Cent Sci - published April 2, 2019
2. Ricci CG, Chen JS, Miao Y, Jinek M, Doudna JA, McCammon JA, Palermo G
Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter.
1. Cell - published April 2, 2019
2. Wang Y, Nguyen NX, She J, Zeng W, Yang Y, Bai XC, Jiang Y
Studying intact bacterial peptidoglycan by proton-detected NMR spectroscopy at 100 kHz MAS frequency.
1. J Struct Biol - published April 1, 2019
2. Bougault C, Ayala I, Vollmer W, Simorre JP, Schanda P
A Bayesian framework for high-throughput T cell receptor pairing.
1. Bioinformatics - published April 1, 2019
2. Holec PV, Berleant J, Bathe M, Birnbaum ME
Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.
1. Neurobiol Dis - published April 1, 2019
2. Weihofen A, Liu Y, Arndt JW, Huy C, Quan C, Smith BA, Baeriswyl JL, Cavegn N, Senn L, Su L, Marsh G, Auluck PK, Montrasio F, Nitsch RM, Hirst WD, Cedarbaum JM, Pepinsky RB, Grimm J, Weinreb PH
¹H, ¹³C, and ¹⁵N backbone resonance assignments for KPC-2, a class A serine-β-lactamase.
1. Biomol NMR Assign - published April 1, 2019
2. VanPelt J, Shurina BA, Ramelot TA, Bonomo RA, Page RC
Advanced Methods for Accessing Protein Shape-Shifting Present New Therapeutic Opportunities.
1. Trends Biochem Sci - published April 1, 2019
2. Knoverek CR, Amarasinghe GK, Bowman GR
Fundus autofluorescence and ellipsoid zone (EZ) line width can be an outcome measurement in RHO-associated autosomal dominant retinitis pigmentosa.
1. Graefes Arch Clin Exp Ophthalmol - published April 1, 2019
2. Takahashi VKL, Takiuti JT, Carvalho-Jr JRL, Xu CL, Duong JK, Mahajan VB, Tsang SH
Taxonomy of the order Mononegavirales: second update 2018.
1. Arch Virol - published April 1, 2019
2. Maes P, Amarasinghe GK, Ayllón MA, Basler CF, Bavari S, Blasdell KR, Briese T, Brown PA, Bukreyev A, Balkema-Buschmann A, Buchholz UJ, Chandran K, Crozier I, de Swart RL, Dietzgen RG, Dolnik O, Domier LL, Drexler JF, Dürrwald R, Dundon WG, Duprex WP, Dye JM, Easton AJ, Fooks AR, Formenty PBH, Fouchier RAM, Freitas-Astúa J, Ghedin E, Griffiths A, Hewson R, Horie M, Hurwitz JL, Hyndman TH, Jiāng D, Kobinger GP, Kondō H, Kurath G, Kuzmin IV, Lamb RA, Lee B, Leroy EM, Lǐ J, Marzano SL, Mühlberger E, Netesov SV, Nowotny N, Palacios G, Pályi B, Pawęska JT, Payne SL, Rima BK, Rota P, Rubbenstroth D, Simmonds P, Smither SJ, Song Q, Song T, Spann K, Stenglein MD, Stone DM, Takada A, Tesh RB, Tomonaga K, Tordo N, Towner JS, van den Hoogen B, Vasilakis N, Wahl V, Walker PJ, Wang D, Wang LF, Whitfield AE, Williams JV, Yè G, Zerbini FM, Zhang YZ, Kuhn JH
Investigation of a sugar N-formyltransferase from the plant pathogen Pantoea ananatis.
1. Protein Sci - published April 1, 2019
2. Hofmeister DL, Thoden JB, Holden HM
Assembly and early maturation of large subunit precursors.
1. RNA - published April 1, 2019
2. Chaker-Margot M, Klinge S
Intracellular Degradation of Helicobacter pylori VacA Toxin as a Determinant of Gastric Epithelial Cell Viability.
1. Infect Immun - published April 1, 2019
2. Foegeding NJ, Raghunathan K, Campbell AM, Kim SW, Lau KS, Kenworthy AK, Cover TL, Ohi MD
Respiratory syncytial virus entry and how to block it.
1. Nat Rev Microbiol - published April 1, 2019
2. Battles MB, McLellan JS
Early Human B Cell Response to Ebola Virus in Four U.S. Survivors of Infection.
1. J Virol - published April 1, 2019
2. Williamson LE, Flyak AI, Kose N, Bombardi R, Branchizio A, Reddy S, Davidson E, Doranz BJ, Fusco ML, Saphire EO, Halfmann PJ, Kawaoka Y, Piper AE, Glass PJ, Crowe JE Jr
Backbone resonance assignments of innate immune evasion protein EapH2 from the S. aureus.
1. Biomol NMR Assign - published April 1, 2019
2. Herrera AI, Dubey A, Geisbrecht BV, Arthanari H, Prakash O
Unsupervised identification of states from voltage recordings of neural networks.
1. J Neurosci Methods - published April 1, 2019
2. Garolini D, Vitalis A, Caflisch A
Regulation of LC3 lipidation by the autophagy-specific class III phosphatidylinositol-3 kinase complex.
1. Mol Biol Cell - published April 1, 2019
2. Brier LW, Ge L, Stjepanovic G, Thelen AM, Hurley JH, Schekman R
Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes.
1. Mol Cell - published April 1, 2019
2. Rogers JM, Waters CT, Seegar TCM, Jarrett SM, Hallworth AN, Blacklow SC, Bulyk ML
The STAT5b Linker Domain Mediates the Selectivity of Catechol Bisphosphates for STAT5b over STAT5a.
1. ACS Chem Biol - published April 1, 2019
2. Gräb J, Berg A, Blechschmidt L, Klüver B, Rubner S, Fu DY, Meiler J, Gräber M, Berg T
Trapped! A Critical Evaluation of Methods for Measuring Total Cellular Uptake versus Cytosolic Localization.
1. Bioconjug Chem - published April 1, 2019
2. Deprey K, Becker L, Kritzer J, Plückthun A
SNAC-tag for sequence-specific chemical protein cleavage.
1. Nat Methods - published April 1, 2019
2. Dang B, Mravic M, Hu H, Schmidt N, Mensa B, DeGrado WF
Isothermal Titration Calorimetry Measurements of Riboswitch-Ligand Interactions.
1. Methods Mol Biol - published April 1, 2019
2. Jones CP, Piszczek G, Ferré-D'Amaré AR
Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures.
1. Elife - published April 1, 2019
2. Wang Y, Sabbagh MF, Gu X, Rattner A, Williams J, Nathans J
Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling.
1. Nat Commun - published April 1, 2019
2. Choi E, Kikuchi S, Gao H, Brodzik K, Nassour I, Yopp A, Singal AG, Zhu H, Yu H
Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer.
1. J Med Chem - published April 1, 2019
2. Lee T, Christov PP, Shaw S, Tarr JC, Zhao B, Veerasamy N, Jeon KO, Mills JJ, Bian Z, Sensintaffar JL, Arnold AL, Fogarty SA, Perry E, Ramsey HE, Cook RS, Hollingshead M, Davis Millin M, Lee KM, Koss B, Budhraja A, Opferman JT, Kim K, Arteaga CL, Moore WJ, Olejniczak ET, Savona MR, Fesik SW
Broad-spectrum enzymatic inhibition of CRISPR-Cas12a.
1. Nat Struct Mol Biol - published April 1, 2019
2. Knott GJ, Thornton BW, Lobba MJ, Liu JJ, Al-Shayeb B, Watters KE, Doudna JA
Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion.
1. Nat Immunol - published April 1, 2019
2. Sawant DV, Yano H, Chikina M, Zhang Q, Liao M, Liu C, Callahan DJ, Sun Z, Sun T, Tabib T, Pennathur A, Corry DB, Luketich JD, Lafyatis R, Chen W, Poholek AC, Bruno TC, Workman CJ, Vignali DAA
Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes.
1. PLoS Pathog - published April 1, 2019
2. O'Brien SP, Swanstrom AE, Pegu A, Ko SY, Immonen TT, Del Prete GQ, Fennessey CM, Gorman J, Foulds KE, Schmidt SD, Doria-Rose N, Williamson C, Hatziioannou T, Bieniasz PD, Li H, Shaw GM, Mascola JR, Koup RA, Kwong PD, Lifson JD, Roederer M, Keele BF
Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically ¹³C- and ¹⁵N-Labeled DNA.
1. Biochemistry - published April 1, 2019
2. Zhou H, Sathyamoorthy B, Stelling A, Xu Y, Xue Y, Pigli YZ, Case DA, Rice PA, Al-Hashimi HM
Zinc intoxication induces ferroptosis in A549 human lung cells.
1. Metallomics - published April 1, 2019
2. Palmer LD, Jordan AT, Maloney KN, Farrow MA, Gutierrez DB, Gant-Branum R, Burns WJ, Romer CE, Tsui T, Allen JL, Beavers WN, Nei YW, Sherrod SD, Lacy DB, Norris JL, McLean JA, Caprioli RM, Skaar EP
Enterococcus faecium secreted antigen A generates muropeptides to enhance host immunity and limit bacterial pathogenesis.
1. Elife - published April 1, 2019
2. Kim B, Wang YC, Hespen CW, Espinosa J, Salje J, Rangan KJ, Oren DA, Kang JY, Pedicord VA, Hang HC
Binding and transport of D-aspartate by the glutamate transporter homolog Glt_Tk.
1. Elife - published April 1, 2019
2. Arkhipova V, Trinco G, Ettema TW, Jensen S, Slotboom DJ, Guskov A
Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains.
1. Nat Commun - published April 1, 2019
2. Heber S, Gáspár I, Tants JN, Günther J, Moya SMF, Janowski R, Ephrussi A, Sattler M, Niessing D
Visualization of clustered protocadherin neuronal self-recognition complexes.
1. Nature - published April 1, 2019
2. Brasch J, Goodman KM, Noble AJ, Rapp M, Mannepalli S, Bahna F, Dandey VP, Bepler T, Berger B, Maniatis T, Potter CS, Carragher B, Honig B, Shapiro L
Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.
1. Nature - published April 1, 2019
2. Lu M, Ma X, Castillo-Menendez LR, Gorman J, Alsahafi N, Ermel U, Terry DS, Chambers M, Peng D, Zhang B, Zhou T, Reichard N, Wang K, Grover JR, Carman BP, Gardner MR, Nikić-Spiegel I, Sugawara A, Arthos J, Lemke EA, Smith AB 3rd, Farzan M, Abrams C, Munro JB, McDermott AB, Finzi A, Kwong PD, Blanchard SC, Sodroski JG, Mothes W
Transposon molecular domestication and the evolution of the RAG recombinase.
1. Nature - published April 1, 2019
2. Zhang Y, Cheng TC, Huang G, Lu Q, Surleac MD, Mandell JD, Pontarotti P, Petrescu AJ, Xu A, Xiong Y, Schatz DG
Structural and functional characterization of an otopetrin family proton channel.
1. Elife - published April 1, 2019
2. Chen Q, Zeng W, She J, Bai X, Jiang Y
An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity.
1. Cell Host Microbe - published April 1, 2019
2. Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Prévost J, Tolbert WD, Lu H, Medjahed H, Gendron-Lepage G, Ortega Delgado GG, Kirk S, Melillo B, Mothes W, Sodroski J, Smith AB 3rd, Kaufmann DE, Wu X, Pazgier M, Rouiller I, Finzi A, Munro JB
Structural basis for auxiliary subunit KCTD16 regulation of the GABAB receptor.
1. Proc Natl Acad Sci U S A - published April 1, 2019
2. Zuo H, Glaaser I, Zhao Y, Kurinov I, Mosyak L, Wang H, Liu J, Park J, Frangaj A, Sturchler E, Zhou M, McDonald P, Geng Y, Slesinger PA, Fan QR
Correction to: Diel rewiring and positive selection of ancient plant proteins enabled evolution of CAM photosynthesis in Agave.
1. BMC Genomics - published April 1, 2019
2. Yin H, Guo HB, Weston DJ, Borland AM, Ranjan P, Abraham PE, Jawdy SS, Wachira J, Tuskan GA, Tschaplinski TJ, Wullschleger SD, Guo H, Hettich RL, Gross SM, Wang Z, Visel A, Yang X
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.
1. Science - published April 1, 2019
2. Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, McKenna MJ, Meydan C, Mishra T, Nasrini J, Piening BD, Rizzardi LF, Sharma K, Siamwala JH, Taylor L, Vitaterna MH, Afkarian M, Afshinnekoo E, Ahadi S, Ambati A, Arya M, Bezdan D, Callahan CM, Chen S, Choi AMK, Chlipala GE, Contrepois K, Covington M, Crucian BE, De Vivo I, Dinges DF, Ebert DJ, Feinberg JI, Gandara JA, George KA, Goutsias J, Grills GS, Hargens AR, Heer M, Hillary RP, Hoofnagle AN, Hook VYH, Jenkinson G, Jiang P, Keshavarzian A, Laurie SS, Lee-McMullen B, Lumpkins SB, MacKay M, Maienschein-Cline MG, Melnick AM, Moore TM, Nakahira K, Patel HH, Pietrzyk R, Rao V, Saito R, Salins DN, Schilling JM, Sears DD, Sheridan CK, Stenger MB, Tryggvadottir R, Urban AE, Vaisar T, Van Espen B, Zhang J, Ziegler MG, Zwart SR, Charles JB, Kundrot CE, Scott GBI, Bailey SM, Basner M, Feinberg AP, Lee SMC, Mason CE, Mignot E, Rana BK, Smith SM, Snyder MP, Turek FW
5'-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger.
1. Chem Commun (Camb) - published April 1, 2019
2. Kumar P, Parmar RG, Brown CR, Willoughby JLS, Foster DJ, Babu IR, Schofield S, Jadhav V, Charisse K, Nair JK, Rajeev KG, Maier MA, Egli M, Manoharan M
Structural basis for inhibition of a response regulator of σS stability by a ClpXP antiadaptor.
1. Genes Dev - published April 1, 2019
2. Dorich V, Brugger C, Tripathi A, Hoskins JR, Tong S, Suhanovsky MM, Sastry A, Wickner S, Gottesman S, Deaconescu AM
Mechanisms of neurodegeneration in a preclinical autosomal dominant retinitis pigmentosa knock-in model with a RhoD190N mutation.
1. Cell Mol Life Sci - published April 1, 2019
2. Sancho-Pelluz J, Cui X, Lee W, Tsai YT, Wu WH, Justus S, Washington I, Hsu CW, Park KS, Koch S, Velez G, Bassuk AG, Mahajan VB, Lin CS, Tsang SH
Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins.
1. Sci Rep - published April 1, 2019
2. Thirawatananond P, McPherson RL, Malhi J, Nathan S, Lambrecht MJ, Brichacek M, Hergenrother PJ, Leung AKL, Gabelli SB
Author Correction: Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses.
1. Nat Immunol - published April 1, 2019
2. Kanekiyo M, Joyce MG, Gillespie RA, Gallagher JR, Andrews SF, Yassine HM, Wheatley AK, Fisher BE, Ambrozak DR, Creanga A, Leung K, Yang ES, Boyoglu-Barnum S, Georgiev IS, Tsybovsky Y, Prabhakaran MS, Andersen H, Kong WP, Baxa U, Zephir KL, Ledgerwood JE, Koup RA, Kwong PD, Harris AK, McDermott AB, Mascola JR, Graham BS
Computational algorithms for in silico profiling of activating mutations in cancer.
1. Cell Mol Life Sci - published April 1, 2019
2. Jordan EJ, Patil K, Suresh K, Park JH, Mosse YP, Lemmon MA, Radhakrishnan R
Biophysical Characterization of a Nanodisc with and without BAX: An Integrative Study Using Molecular Dynamics Simulations and Cryo-EM.
1. Structure - published April 1, 2019
2. López CA, Swift MF, Xu XP, Hanein D, Volkmann N, Gnanakaran S
Early Onset Neovascular Inflammatory Vitreoretinopathy Due to a De Novo CAPN5 Mutation: Report of a Case.
1. Ocul Immunol Inflamm - published April 1, 2019
2. O'Keefe G, Hanif AM, Mahajan VB, Jain N
Nitrosative stress sensing in Porphyromonas gingivalis: structure of and heme binding by the transcriptional regulator HcpR.
1. Acta Crystallogr D Struct Biol - published April 1, 2019
2. Belvin BR, Musayev FN, Burgner J, Scarsdale JN, Escalante CR, Lewis JP
Announcing mandatory submission of PDBx/mmCIF format files for crystallographic depositions to the Protein Data Bank (PDB).
1. Acta Crystallogr D Struct Biol - published April 1, 2019
2. Adams PD, Afonine PV, Baskaran K, Berman HM, Berrisford J, Bricogne G, Brown DG, Burley SK, Chen M, Feng Z, Flensburg C, Gutmanas A, Hoch JC, Ikegawa Y, Kengaku Y, Krissinel E, Kurisu G, Liang Y, Liebschner D, Mak L, Markley JL, Moriarty NW, Murshudov GN, Noble M, Peisach E, Persikova I, Poon BK, Sobolev OV, Ulrich EL, Velankar S, Vonrhein C, Westbrook J, Wojdyr M, Yokochi M, Young JY
Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression.
1. J Exp Clin Cancer Res - published April 1, 2019
2. Jin H, Jang Y, Cheng N, Li Q, Cui PF, Zhou ZW, Jiang HL, Cho MH, Westover KD, Tan QY, Xu CX
Treatment with the Pseudomonas aeruginosa glycoside hydrolase PslG combats wound infection by improving antibiotic efficacy and host innate immune activity.
1. Antimicrob Agents Chemother - published April 1, 2019
2. Pestrak MJ, Baker P, Dellos-Nolan S, Hill PJ, da Silva DP, Silver H, Lacdao I, Raju D, Parsek MR, Wozniak DJ, Howell PL
VPS4 triggers constriction and cleavage of ESCRT-III helical filaments.
1. Sci Adv - published April 1, 2019
2. Maity S, Caillat C, Miguet N, Sulbaran G, Effantin G, Schoehn G, Roos WH, Weissenhorn W
Commonly used FRET fluorophores promote collapse of an otherwise disordered protein.
1. Proc Natl Acad Sci U S A - published April 1, 2019
2. Riback JA, Bowman MA, Zmyslowski AM, Plaxco KW, Clark PL, Sosnick TR
Bioproduction of pure, kilobase-scale single-stranded DNA.
1. Sci Rep - published April 1, 2019
2. Shepherd TR, Du RR, Huang H, Wamhoff EC, Bathe M
Probing prothrombin structure by limited proteolysis.
1. Sci Rep - published April 1, 2019
2. Acquasaliente L, Pelc LA, Di Cera E
Monoclonal antibodies point to Achilles' heel in picornavirus capsid.
1. PLoS Biol - published April 1, 2019
2. Bostina M
CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants.
1. Biochem J - published April 1, 2019
2. Bloomer DT, Kitevska-Ilioski T, Pantaki-Eimany D, Ji Y, Miles MA, Heras B, Hawkins C
Therapeutic Window for Phosphodiesterase 6-Related Retinitis Pigmentosa.
1. JAMA Ophthalmol - published April 1, 2019
2. Wang NK, Mahajan VB, Tsang SH
Inhibition Mechanism of Urease by Au(III) Compounds Unveiled by X-ray Diffraction Analysis.
1. ACS Med Chem Lett - published April 1, 2019
2. Mazzei L, Wenzel MN, Cianci M, Palombo M, Casini A, Ciurli S
Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk.
1. Nat Commun - published April 1, 2019
2. King LB, West BR, Moyer CL, Gilchuk P, Flyak A, Ilinykh PA, Bombardi R, Hui S, Huang K, Bukreyev A, Crowe JE Jr, Saphire EO
Synthesis of HDAC Substrate Peptidomimetic Inhibitors Using Fmoc Amino Acids Incorporating Zinc-Binding Groups.
1. Org Lett - published April 1, 2019
2. Mahindra A, Millard CJ, Black I, Archibald LJ, Schwabe JWR, Jamieson AG
Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine.
1. Sci Immunol - published April 1, 2019
2. Matsuda K, Huang J, Zhou T, Sheng Z, Kang BH, Ishida E, Griesman T, Stuccio S, Bolkhovitinov L, Wohlbold TJ, Chromikova V, Cagigi A, Leung K, Andrews S, Cheung CSF, Pullano AA, Plyler J, Soto C, Zhang B, Yang Y, Joyce MG, Tsybovsky Y, Wheatley A, Narpala SR, Guo Y, Darko S, Bailer RT, Poole A, Liang CJ, Smith J, Alexander J, Gurwith M, Migueles SA, Koup RA, Golding H, Khurana S, McDermott AB, Shapiro L, Krammer F, Kwong PD, Connors M
Tetramethylpyrazine attenuates blood-brain barrier disruption in ischemia/reperfusion injury through the JAK/STAT signaling pathway.
1. Eur J Pharmacol - published April 1, 2019
2. Gong P, Zhang Z, Zou Y, Tian Q, Han S, Xu Z, Liao J, Gao L, Chen Q, Li M
A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology.
1. Cell - published April 1, 2019
2. Chen H, Nwe PK, Yang Y, Rosen CE, Bielecka AA, Kuchroo M, Cline GW, Kruse AC, Ring AM, Crawford JM, Palm NW
Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity.
1. Cell - published April 1, 2019
2. Cadena C, Ahmad S, Xavier A, Willemsen J, Park S, Park JW, Oh SW, Fujita T, Hou F, Binder M, Hur S
Humoral Response to the HIV-1 Envelope V2 Region in a Thai Early Acute Infection Cohort.
1. Cells - published April 1, 2019
2. Trinh HV, Gohain N, Pham PT, Hamlin C, Song H, Sanders-Buell E, Bose M, Eller LA, Tovanabutra S, Michael NL, Robb ML, Joyce MG, Rao M
Structure of the human ClC-1 chloride channel.
1. PLoS Biol - published April 1, 2019
2. Wang K, Preisler SS, Zhang L, Cui Y, Missel JW, Grønberg C, Gotfryd K, Lindahl E, Andersson M, Calloe K, Egea PF, Klaerke DA, Pusch M, Pedersen PA, Zhou ZH, Gourdon P
Homozygous TRPV4 mutation causes congenital distal spinal muscular atrophy and arthrogryposis.
1. Neurol Genet - published April 1, 2019
2. Velilla J, Marchetti MM, Toth-Petroczy A, Grosgogeat C, Bennett AH, Carmichael N, Estrella E, Darras BT, Frank NY, Krier J, Gaudet R, Gupta VA
FAM105A/OTULINL Is a Pseudodebuiquitinase of the OTU-Class that Localizes to the ER Membrane.
1. Structure - published April 1, 2019
2. Ceccarelli DF, Ivantsiv S, Mullin AA, Coyaud E, Manczyk N, Maisonneuve P, Kurinov I, Zhao L, Go C, Gingras AC, Raught B, Cordes S, Sicheri F
Unexpected connections between type VI-B CRISPR-Cas systems, bacterial natural competence, ubiquitin signaling network and DNA modification through a distinct family of membrane proteins.
1. FEMS Microbiol Lett - published April 1, 2019
2. Makarova KS, Gao L, Zhang F, Koonin EV