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125 Member Publications for March 2019

Using In Vitro Pull-Down and In-Cell Overexpression Assays to Study Protein Interactions with Arrestin.
1. Methods Mol Biol - published March 29, 2019
2. Perry NA, Zhan X, Gurevich EV, Iverson TM, Gurevich VV
Exploration of Microbial Diversity to Discover Novel Molecular Technologies.
1. Keio J Med - published March 26, 2019
2. Zhang F
Semisynthesis of ubiquitinated histone H2B with a native or nonhydrolyzable linkage.
1. Methods Enzymol - published March 10, 2019
2. Morgan M, Jbara M, Brik A, Wolberger C
How has DSM-5 Affected Autism Diagnosis? A 5-Year Follow-Up Systematic Literature Review and Meta-analysis.
1. J Autism Dev Disord - published March 9, 2019
2. Kulage KM, Goldberg J, Usseglio J, Romero D, Bain JM, Smaldone AM
An alternative N-terminal fold of the intestine-specific annexin A13a induces dimerization and regulates membrane-binding.
1. J Biol Chem - published March 8, 2019
2. McCulloch KM, Yamakawa I, Shifrin DA Jr, McConnell RE, Foegeding NJ, Singh PK, Mao S, Tyska MJ, Iverson TM
Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi.
1. ACS Infect Dis - published March 8, 2019
2. Guedes-da-Silva FH, Batista DDGJ, Da Silva CF, Pavão BP, Batista MM, Moreira OC, Souza LRQ, Britto C, Rachakonda G, Villalta F, Lepesheva GI, Soeiro MNC
Stoichiometry controls activity of phase-separated clusters of actin signaling proteins.
1. Science - published March 8, 2019
2. Case LB, Zhang X, Ditlev JA, Rosen MK
Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis.
1. Science - published March 8, 2019
2. Ladinsky MS, Araujo LP, Zhang X, Veltri J, Galan-Diez M, Soualhi S, Lee C, Irie K, Pinker EY, Narushima S, Bandyopadhyay S, Nagayama M, Elhenawy W, Coombes BK, Ferraris RP, Honda K, Iliev ID, Gao N, Bjorkman PJ, Ivanov II
Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor.
1. Science - published March 8, 2019
2. Bräuer P, Parker JL, Gerondopoulos A, Zimmermann I, Seeger MA, Barr FA, Newstead S
A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS.
1. Science - published March 8, 2019
2. Huang WYC, Alvarez S, Kondo Y, Lee YK, Chung JK, Lam HYM, Biswas KH, Kuriyan J, Groves JT
The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy.
1. Nat Commun - published March 8, 2019
2. Wang GZ, Zhang L, Zhao XC, Gao SH, Qu LW, Yu H, Fang WF, Zhou YC, Liang F, Zhang C, Huang YC, Liu Z, Fu YX, Zhou GB
A Ca(2+)-regulated deAMPylation switch in human and bacterial FIC proteins.
1. Nat Commun - published March 8, 2019
2. Veyron S, Oliva G, Rolando M, Buchrieser C, Peyroche G, Cherfils J
The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2.
1. Mol Cell - published March 8, 2019
2. Schopf FH, Huber EM, Dodt C, Lopez A, Biebl MM, Rutz DA, Mühlhofer M, Richter G, Madl T, Sattler M, Groll M, Buchner J
Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA.
1. Cell - published March 7, 2019
2. Barnett KC, Coronas-Serna JM, Zhou W, Ernandes MJ, Cao A, Kranzusch PJ, Kagan JC
Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling.
1. Cell - published March 7, 2019
2. Pan L, Fu TM, Zhao W, Zhao L, Chen W, Qiu C, Liu W, Liu Z, Piai A, Fu Q, Chen S, Wu H, Chou JJ
Utility of Hybrid Transferrin Binding Protein Antigens for Protection Against Pathogenic Neisseria Species.
1. Front Immunol - published March 7, 2019
2. Fegan JE, Calmettes C, Islam EA, Ahn SK, Chaudhuri S, Yu RH, Gray-Owen SD, Moraes TF, Schryvers AB
A widely distributed diheme enzyme from Burkholderia that displays an atypically stable bis-Fe(IV) state.
1. Nat Commun - published March 7, 2019
2. Rizzolo K, Cohen SE, Weitz AC, López Muñoz MM, Hendrich MP, Drennan CL, Elliott SJ
Discovery and structure of the antimicrobial lasso peptide citrocin.
1. J Biol Chem - published March 7, 2019
2. Cheung-Lee WL, Parry ME, Jaramillo Cartagena A, Darst SA, Link AJ
Evidence for hormonal control of heart regenerative capacity during endothermy acquisition.
1. Science - published March 7, 2019
2. Hirose K, Payumo AY, Cutie S, Hoang A, Zhang H, Guyot R, Lunn D, Bigley RB, Yu H, Wang J, Smith M, Gillett E, Muroy SE, Schmid T, Wilson E, Field KA, Reeder DM, Maden M, Yartsev MM, Wolfgang MJ, Grützner F, Scanlan TS, Szweda LI, Buffenstein R, Hu G, Flamant F, Olgin JE, Huang GN
Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids.
1. Nat Commun - published March 7, 2019
2. Liberta F, Loerch S, Rennegarbe M, Schierhorn A, Westermark P, Westermark GT, Hazenberg BPC, Grigorieff N, Fändrich M, Schmidt M
Human DNA polymerase η has reverse transcriptase activity in cellular environments.
1. J Biol Chem - published March 6, 2019
2. Su Y, Ghodke PP, Egli M, Li L, Wang Y, Guengerich FP
Maturation of the respiratory complex II flavoprotein.
1. Curr Opin Struct Biol - published March 6, 2019
2. Sharma P, Maklashina E, Cecchini G, Iverson TM
Cheating Death: New Molecules Block BAX.
1. Trends Mol Med - published March 6, 2019
2. Walensky LD
Therapeutic Remodeling of the Tumor Microenvironment Enhances Nanoparticle Delivery.
1. Adv Sci (Weinh) - published March 6, 2019
2. Chen Y, Liu X, Yuan H, Yang Z, von Roemeling CA, Qie Y, Zhao H, Wang Y, Jiang W, Kim BYS
Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype.
1. Cell Chem Biol - published March 6, 2019
2. Olson CM, Liang Y, Leggett A, Park WD, Li L, Mills CE, Elsarrag SZ, Ficarro SB, Zhang T, Düster R, Geyer M, Sim T, Marto JA, Sorger PK, Westover KD, Lin CY, Kwiatkowski N, Gray NS
Structural Basis for the Activation of the Deubiquitinase Calypso by the Polycomb Protein ASX.
1. Structure - published March 5, 2019
2. De I, Chittock EC, Grötsch H, Miller TCR, McCarthy AA, Müller CW
Protein structure aids predicting functional perturbation of missense variants in SCN5A and KCNQ1.
1. Comput Struct Biotechnol J - published March 5, 2019
2. Kroncke BM, Mendenhall J, Smith DK, Sanders CR, Capra JA, George AL, Blume JD, Meiler J, Roden DM
Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes.
1. ACS Infect Dis - published March 5, 2019
2. Markley JL, Fang L, Gasparrini AJ, Symister CT, Kumar H, Tolia NH, Dantas G, Wencewicz TA
Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies.
1. Sci Rep - published March 5, 2019
2. Bajic G, van der Poel CE, Kuraoka M, Schmidt AG, Carroll MC, Kelsoe G, Harrison SC
Models to determine the kinetic mechanisms of ion-coupled transporters.
1. J Gen Physiol - published March 4, 2019
2. Lolkema JS, Slotboom DJ
Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus.
1. Nat Microbiol - published March 4, 2019
2. Kraemer MUG, Reiner RC Jr, Brady OJ, Messina JP, Gilbert M, Pigott DM, Yi D, Johnson K, Earl L, Marczak LB, Shirude S, Davis Weaver N, Bisanzio D, Perkins TA, Lai S, Lu X, Jones P, Coelho GE, Carvalho RG, Van Bortel W, Marsboom C, Hendrickx G, Schaffner F, Moore CG, Nax HH, Bengtsson L, Wetter E, Tatem AJ, Brownstein JS, Smith DL, Lambrechts L, Cauchemez S, Linard C, Faria NR, Pybus OG, Scott TW, Liu Q, Yu H, Wint GRW, Hay SI, Golding N
Structural Principles in Robo Activation and Auto-inhibition.
1. Cell - published March 4, 2019
2. Barak R, Yom-Tov G, Guez-Haddad J, Gasri-Plotnitsky L, Maimon R, Cohen-Berkman M, McCarthy AA, Perlson E, Henis-Korenblit S, Isupov MN, Opatowsky Y
The phenylketonuria-associated substitution R68S converts phenylalanine hydroxylase to a constitutively active enzyme but reduces its stability.
1. J Biol Chem - published March 2, 2019
2. Khan CA, Meisburger SP, Ando N, Fitzpatrick PF
A Selectivity Filter Gate Controls Voltage-Gated Calcium Channel Calcium-Dependent Inactivation.
1. Neuron - published March 2, 2019
2. Abderemane-Ali F, Findeisen F, Rossen ND, Minor DL Jr
Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques.
1. Mol Cell - published March 2, 2019
2. Petrovic J, Zhou Y, Fasolino M, Goldman N, Schwartz GW, Mumbach MR, Nguyen SC, Rome KS, Sela Y, Zapataro Z, Blacklow SC, Kruhlak MJ, Shi J, Aster JC, Joyce EF, Little SC, Vahedi G, Pear WS, Faryabi RB
Menaquinone Biosynthesis: Biochemical and Structural Studies of Chorismate Dehydratase.
1. Biochemistry - published March 2, 2019
2. Mahanta N, Hicks KA, Naseem S, Zhang Y, Fedoseyenko D, Ealick SE, Begley TP
Modulation of HIV-1 gene expression by binding of a ULM motif in the Rev protein to UHM-containing splicing factors.
1. Nucleic Acids Res - published March 2, 2019
2. Pabis M, Corsini L, Vincendeau M, Tripsianes K, Gibson TJ, Brack-Werner R, Sattler M
Structural analysis of chloroplast tail-anchored membrane protein recognition by ArsA1.
1. Plant J - published March 2, 2019
2. Lin TW, Chen CC, Wu SM, Chang YC, Li YC, Su YW, Hsiao CD, Chang HY
Synthesis and Biophysical Characterization of RNAs Containing 2'-Fluorinated Northern Methanocarbacyclic Nucleotides.
1. Org Lett - published March 2, 2019
2. Akabane-Nakata M, Kumar P, Das RS, Erande ND, Matsuda S, Egli M, Manoharan M
The ATPase mechanism of UvrA2 reveals the distinct roles of proximal and distal ATPase sites in nucleotide excision repair.
1. Nucleic Acids Res - published March 2, 2019
2. Case BC, Hartley S, Osuga M, Jeruzalmi D, Hingorani MM
Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.
1. Proc Natl Acad Sci U S A - published March 2, 2019
2. Raman S, Beilschmidt M, To M, Lin K, Lui F, Jmeian Y, Ng M, Fernandez M, Fu Y, Mascall K, Duque A, Wang X, Pan G, Angers S, Moffat J, Sidhu SS, Magram J, Sinclair AM, Fransson J, Julien JP
The BARA necessities of PtdIns 3-kinase activation in autophagy.
1. Autophagy - published March 2, 2019
2. Chang C, Young LN, Hurley JH
The Vexing Complexity of the Amyloidogenic Pathway.
1. Protein Sci - published March 2, 2019
2. Castro MA, Hadziselimovic A, Sanders CR
High-resolution archaellum structure reveals a conserved metal-binding site.
1. EMBO Rep - published March 2, 2019
2. Meshcheryakov VA, Shibata S, Schreiber MT, Villar-Briones A, Jarrell KF, Aizawa SI, Wolf M
Publisher Correction: Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus.
1. Nat Microbiol - published March 2, 2019
2. Kraemer MUG, Reiner RC Jr, Brady OJ, Messina JP, Gilbert M, Pigott DM, Yi D, Johnson K, Earl L, Marczak LB, Shirude S, Weaver ND, Bisanzio D, Perkins TA, Lai S, Lu X, Jones P, Coelho GE, Carvalho RG, Van Bortel W, Marsboom C, Hendrickx G, Schaffner F, Moore CG, Nax HH, Bengtsson L, Wetter E, Tatem AJ, Brownstein JS, Smith DL, Lambrechts L, Cauchemez S, Linard C, Faria NR, Pybus OG, Scott TW, Liu Q, Yu H, Wint GRW, Hay SI, Golding N
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models.
1. Elife - published March 2, 2019
2. Silva MC, Ferguson FM, Cai Q, Donovan KA, Nandi G, Patnaik D, Zhang T, Huang HT, Lucente DE, Dickerson BC, Mitchison TJ, Fischer ES, Gray NS, Haggarty SJ
Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14 in ribosome biogenesis.
1. RNA - published March 2, 2019
2. Boneberg F, Brandmann T, Kobel L, van den Heuvel J, Bargsten K, Bammert L, Kutay U, Jinek M
Re-Engineering RNA Molecules into Therapeutic Agents.
1. Acc Chem Res - published March 2, 2019
2. Egli M, Manoharan M
Dynamic Dystroglycan Complexes Mediate Cell Entry of Lassa Virus.
1. mBio - published March 2, 2019
2. Herrador A, Fedeli C, Radulovic E, Campbell KP, Moreno H, Gerold G, Kunz S
High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage.
1. Cell Rep - published March 2, 2019
2. Slaymaker IM, Mesa P, Kellner MJ, Kannan S, Brignole E, Koob J, Feliciano PR, Stella S, Abudayyeh OO, Gootenberg JS, Strecker J, Montoya G, Zhang F
The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction.
1. FASEB J - published March 2, 2019
2. De Palma RM, Parnham SR, Li Y, Oaks JJ, Peterson YK, Szulc ZM, Roth BM, Xing Y, Ogretmen B
X-ray structures of the high-affinity copper transporter Ctr1.
1. Nat Commun - published March 2, 2019
2. Ren F, Logeman BL, Zhang X, Liu Y, Thiele DJ, Yuan P
Packing of apolar side chains enables accurate design of highly stable membrane proteins.
1. Science - published March 2, 2019
2. Mravic M, Thomaston JL, Tucker M, Solomon PE, Liu L, DeGrado WF
Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules.
1. Proc Natl Acad Sci U S A - published March 2, 2019
2. Cao Y, Ma E, Cestellos-Blanco S, Zhang B, Qiu R, Su Y, Doudna JA, Yang P
An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation.
1. J Biomech - published March 2, 2019
2. Harris C, Thorpe SD, Rushwan S, Wang W, Thompson CL, Peacock JL, Knight MM, Gooptu B, Greenough A
Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation.
1. Nat Commun - published March 2, 2019
2. Malacaria E, Pugliese GM, Honda M, Marabitti V, Aiello FA, Spies M, Franchitto A, Pichierri P
Genomic profiling in pancreatic ductal adenocarcinoma and a pathway towards therapy individualization: A scoping review.
1. Cancer Treat Rev - published March 2, 2019
2. Singh RR, Goldberg J, Varghese AM, Yu KH, Park W, O'Reilly EM
Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.
1. Nat Commun - published March 2, 2019
2. Simonetta KR, Taygerly J, Boyle K, Basham SE, Padovani C, Lou Y, Cummins TJ, Yung SL, von Soly SK, Kayser F, Kuriyan J, Rape M, Cardozo M, Gallop MA, Bence NF, Barsanti PA, Saha A
Conformational Dynamics of the HIV-Vif Protein Complex.
1. Biophys J - published March 2, 2019
2. Ball KA, Chan LM, Stanley DJ, Tierney E, Thapa S, Ta HM, Burton L, Binning JM, Jacobson MP, Gross JD
Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis.
1. Cell Stem Cell - published March 2, 2019
2. Weng Q, Wang J, Wang J, He D, Cheng Z, Zhang F, Verma R, Xu L, Dong X, Liao Y, He X, Potter A, Zhang L, Zhao C, Xin M, Zhou Q, Aronow BJ, Blackshear PJ, Rich JN, He Q, Zhou W, Suvà ML, Waclaw RR, Potter SS, Yu G, Lu QR
Feedback regulation of RTK signaling in development.
1. Dev Biol - published March 1, 2019
2. Neben CL, Lo M, Jura N, Klein OD
Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in Aβ and TAU proteostasis.
1. Hum Mol Genet - published March 1, 2019
2. Sullivan SE, Liao M, Smith RV, White C, Lagomarsino VN, Xu J, Taga M, Bennett DA, De Jager PL, Young-Pearse TL
Overexpression-mediated activation of MET in the Golgi promotes HER3/ERBB3 phosphorylation.
1. Oncogene - published March 1, 2019
2. Frazier NM, Brand T, Gordan JD, Grandis J, Jura N
A high-throughput inhibition assay to study MERS-CoV antibody interactions using image cytometry.
1. J Virol Methods - published March 1, 2019
2. Rosen O, Chan LL, Abiona OM, Gough P, Wang L, Shi W, Zhang Y, Wang N, Kong WP, McLellan JS, Graham BS, Corbett KS
Conformational flexibility in the enterovirus RNA replication platform.
1. RNA - published March 1, 2019
2. Warden MS, Cai K, Cornilescu G, Burke JE, Ponniah K, Butcher SE, Pascal SM
OptSSeq explores enzyme expression and function landscapes to maximize isobutanol production rate.
1. Metab Eng - published March 1, 2019
2. Ghosh IN, Martien J, Hebert AS, Zhang Y, Coon JJ, Amador-Noguez D, Landick R
Host-defense peptides AC12, DK16 and RC11 with immunomodulatory activity isolated from Hypsiboas raniceps skin secretion.
1. Peptides - published March 1, 2019
2. Popov CSFC, Magalhães BS, Goodfellow BJ, Bocca AL, Pereira DM, Andrade PB, Valentão P, Pereira PJB, Rodrigues JE, de Holanda Veloso PH Júnior, Rezende TMB
Examination and Reconstruction of Three Ancient Endogenous Parvovirus Capsid Protein Gene Remnants Found in Rodent Genomes.
1. J Virol - published March 1, 2019
2. Callaway HM, Subramanian S, Urbina CA, Barnard KN, Dick RA, Bator CM, Hafenstein SL, Gifford RJ, Parrish CR
IL (Interleukin)-33 Suppresses Abdominal Aortic Aneurysm by Enhancing Regulatory T-Cell Expansion and Activity.
1. Arterioscler Thromb Vasc Biol - published March 1, 2019
2. Li J, Xia N, Wen S, Li D, Lu Y, Gu M, Tang T, Jiao J, Lv B, Nie S, Liao M, Liao Y, Yang X, Hu Y, Shi GP, Cheng X
Crystal structure of the human Scribble PDZ1 domain bound to the PDZ-binding motif of APC.
1. FEBS Lett - published March 1, 2019
2. How JY, Caria S, Humbert PO, Kvansakul M
Dismantling a Toxin to Disarm a Superbug.
1. Trends Pharmacol Sci - published March 1, 2019
2. Icho S, Melnyk RA
Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH.
1. J Mol Biol - published March 1, 2019
2. Butler VJ, Cortopassi WA, Argouarch AR, Ivry SL, Craik CS, Jacobson MP, Kao AW
Consideration of sample motion in cryo-tomography based on alignment residual interpolation.
1. J Struct Biol - published March 1, 2019
2. Fernandez JJ, Li S, Agard DA
Identifying a potential biomarker for primary focal segmental glomerulosclerosis and its association with recurrence after transplantation.
1. Clin Transplant - published March 1, 2019
2. Harel E, Shoji J, Abraham V, Miller L, Laszik Z, Thurison T, King A, Olshen A, Leung J, Szabo G, Hann B, Høyer-Hansen G, Craik CS, Vincenti F
Site-Specific Oxidation State Assignments of the Iron Atoms in the [4Fe:4S]^2+/1+/0 States of the Nitrogenase Fe-Protein.
1. Angew Chem Int Ed Engl - published March 1, 2019
2. Wenke BB, Spatzal T, Rees DC
Conformational Stabilization and Rapid Labeling of a 29-Residue Peptide by a Small Molecule Reaction Partner.
1. Biochemistry - published March 1, 2019
2. Evans ED, Gates ZP, Sun ZJ, Mijalis AJ, Pentelute BL
Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses.
1. Nat Immunol - published March 1, 2019
2. Kanekiyo M, Joyce MG, Gillespie RA, Gallagher JR, Andrews SF, Yassine HM, Wheatley AK, Fisher BE, Ambrozak DR, Creanga A, Leung K, Yang ES, Boyoglu-Barnum S, Georgiev IS, Tsybovsky Y, Prabhakaran MS, Andersen H, Kong WP, Baxa U, Zephir KL, Ledgerwood JE, Koup RA, Kwong PD, Harris AK, McDermott AB, Mascola JR, Graham BS
Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.
1. ACS Chem Biol - published March 1, 2019
2. McNally R, Li Q, Li K, Dekker C, Vangrevelinghe E, Jones M, Chène P, Machauer R, Radimerski T, Eck MJ
Bacterial cGAS-like enzymes synthesize diverse nucleotide signals.
1. Nature - published March 1, 2019
2. Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ, Kranzusch PJ
Minimal NMR distance information for rigidity of protein graphs.
1. Discrete Appl Math - published March 1, 2019
2. Lavor C, Liberti L, Donald B, Worley B, Bardiaux B, Malliavin TE, Nilges M
Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity.
1. Genes Dev - published March 1, 2019
2. Shimojo M, Madara J, Pankow S, Liu X, Yates J 3rd, Südhof TC, Maximov A
Structural basis for KCTD-mediated rapid desensitization of GABAB signalling.
1. Nature - published March 1, 2019
2. Zheng S, Abreu N, Levitz J, Kruse AC
Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors.
1. Crit Rev Biochem Mol Biol - published March 1, 2019
2. Özen A, Prachanronarong K, Matthew AN, Soumana DI, Schiffer CA
Lipid-filled vesicles modulate macrophages.
1. Science - published March 1, 2019
2. Antonyak MA, Lukey MJ, Cerione RA
HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2.
1. Proc Natl Acad Sci U S A - published March 1, 2019
2. Cao J, Sun L, Aramsangtienchai P, Spiegelman NA, Zhang X, Huang W, Seto E, Lin H
Author Correction: A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance.
1. Nat Commun - published March 1, 2019
2. Furlong EJ, Lo AW, Kurth F, Premkumar L, Totsika M, Achard MES, Halili MA, Heras B, Whitten AE, Choudhury HG, Schembri MA, Martin JL
Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O2 activation.
1. Proc Natl Acad Sci U S A - published March 1, 2019
2. Appel MJ, Meier KK, Lafrance-Vanasse J, Lim H, Tsai CL, Hedman B, Hodgson KO, Tainer JA, Solomon EI, Bertozzi CR
The Dynamic Structures of the Type IV Pilus.
1. Microbiol Spectr - published March 1, 2019
2. McCallum M, Burrows LL, Howell PL
Planar-Polarized Semaphorin-5c and Plexin A Promote the Collective Migration of Epithelial Cells in Drosophila.
1. Curr Biol - published March 1, 2019
2. Stedden CG, Menegas W, Zajac AL, Williams AM, Cheng S, Özkan E, Horne-Badovinac S
Multiple functional neurosteroid binding sites on GABAA receptors.
1. PLoS Biol - published March 1, 2019
2. Chen ZW, Bracamontes JR, Budelier MM, Germann AL, Shin DJ, Kathiresan K, Qian MX, Manion B, Cheng WWL, Reichert DE, Akk G, Covey DF, Evers AS
MXCuBE2: the dawn of MXCuBE Collaboration.
1. J Synchrotron Radiat - published March 1, 2019
2. Oscarsson M, Beteva A, Flot D, Gordon E, Guijarro M, Leonard G, McSweeney S, Monaco S, Mueller-Dieckmann C, Nanao M, Nurizzo D, Popov AN, von Stetten D, Svensson O, Rey-Bakaikoa V, Chado I, Chavas LMG, Gadea L, Gourhant P, Isabet T, Legrand P, Savko M, Sirigu S, Shepard W, Thompson A, Mueller U, Nan J, Eguiraun M, Bolmsten F, Nardella A, Milàn-Otero A, Thunnissen M, Hellmig M, Kastner A, Schmuckermaier L, Gerlach M, Feiler C, Weiss MS, Bowler MW, Gobbo A, Papp G, Sinoir J, McCarthy AA, Karpics I, Nikolova M, Bourenkov G, Schneider T, Andreu J, Cuní G, Juanhuix J, Boer R, Fogh R, Keller P, Flensburg C, Paciorek W, Vonrhein C, Bricogne G, de Sanctis D
Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination.
1. Chem Commun (Camb) - published March 1, 2019
2. Saez Cabodevilla J, Volbeda A, Hamelin O, Latour JM, Gigarel O, Clémancey M, Darnault C, Reichmann D, Amara P, Fontecilla-Camps JC, Ollagnier de Choudens S
The complete structure of the human TFIIH core complex.
1. Elife - published March 1, 2019
2. Greber BJ, Toso DB, Fang J, Nogales E
Structural mechanisms of phospholipid activation of the human TPC2 channel.
1. Elife - published March 1, 2019
2. She J, Zeng W, Guo J, Chen Q, Bai X, Jiang Y
Fine tuning of σE activation suppresses multiple assembly-defective mutations in Escherichia coli.
1. J Bacteriol - published March 1, 2019
2. Hart EM, O'Connell A, Tang K, Wzorek JS, Grabowicz M, Kahne D, Silhavy TJ
How Second Coordination Sphere Modifications Can Impact Metal Structures in Proteins: A Crystallographic Evaluation.
1. Chemistry - published March 1, 2019
2. Pecoraro VL, Ruckthong L, Stuckey JA
A multi-targeted probe-based strategy to identify signaling vulnerabilities in cancers.
1. J Biol Chem - published March 1, 2019
2. Rao S, Du G, Hafner M, Subramanian K, Sorger PK, Gray NS
Aromatic 19F-13C TROSY: a background-free approach to probe biomolecular structure, function, and dynamics.
1. Nat Methods - published March 1, 2019
2. Boeszoermenyi A, Chhabra S, Dubey A, Radeva DL, Burdzhiev NT, Chanev CD, Petrov OI, Gelev VM, Zhang M, Anklin C, Kovacs H, Wagner G, Kuprov I, Takeuchi K, Arthanari H
Global Outbreaks and Origins of a Chikungunya Virus Variant Carrying Mutations Which May Increase Fitness for Aedes aegypti: Revelations from the 2016 Mandera, Kenya Outbreak.
1. Am J Trop Med Hyg - published March 1, 2019
2. Maljkovic Berry I, Eyase F, Pollett S, Konongoi SL, Joyce MG, Figueroa K, Ofula V, Koka H, Koskei E, Nyunja A, Mancuso JD, Jarman RG, Sang R
The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency.
1. Sci Rep - published March 1, 2019
2. Manczyk N, Veggiani G, Teyra J, Strilchuk AW, Sidhu SS, Sicheri F
CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement.
1. Nat Commun - published March 1, 2019
2. Vassal-Stermann E, Effantin G, Zubieta C, Burmeister W, Iseni F, Wang H, Lieber A, Schoehn G, Fender P
Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
1. Cell Rep - published March 1, 2019
2. Aho ER, Wang J, Gogliotti RD, Howard GC, Phan J, Acharya P, Macdonald JD, Cheng K, Lorey SL, Lu B, Wenzel S, Foshage AM, Alvarado J, Wang F, Shaw JG, Zhao B, Weissmiller AM, Thomas LR, Vakoc CR, Hall MD, Hiebert SW, Liu Q, Stauffer SR, Fesik SW, Tansey WP
Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ.
1. IUCrJ - published March 1, 2019
2. Zee CT, Glynn C, Gallagher-Jones M, Miao J, Santiago CG, Cascio D, Gonen T, Sawaya MR, Rodriguez JA
Structural and dynamical rationale for fatty acid unsaturation in Escherichia coli.
1. Proc Natl Acad Sci U S A - published March 1, 2019
2. Dodge GJ, Patel A, Jaremko KL, McCammon JA, Smith JL, Burkart MD
On the removal of initial state bias from simulation data.
1. J Chem Phys - published March 1, 2019
2. Bacci M, Caflisch A, Vitalis A
Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual.
1. Immunity - published March 1, 2019
2. Krebs SJ, Kwon YD, Schramm CA, Law WH, Donofrio G, Zhou KH, Gift S, Dussupt V, Georgiev IS, Schätzle S, McDaniel JR, Lai YT, Sastry M, Zhang B, Jarosinski MC, Ransier A, Chenine AL, Asokan M, Bailer RT, Bose M, Cagigi A, Cale EM, Chuang GY, Darko S, Driscoll JI, Druz A, Gorman J, Laboune F, Louder MK, McKee K, Mendez L, Moody MA, O'Sullivan AM, Owen C, Peng D, Rawi R, Sanders-Buell E, Shen CH, Shiakolas AR, Stephens T, Tsybovsky Y, Tucker C, Verardi R, Wang K, Zhou J, Zhou T, Georgiou G, Alam SM, Haynes BF, Rolland M, Matyas GR, Polonis VR, McDermott AB, Douek DC, Shapiro L, Tovanabutra S, Michael NL, Mascola JR, Robb ML, Kwong PD, Doria-Rose NA
Cellular sensing by phase separation: Using the process, not just the products.
1. J Biol Chem - published March 1, 2019
2. Yoo H, Triandafillou C, Drummond DA
The Structure of the Nuclear Pore Complex (An Update).
1. Annu Rev Biochem - published March 1, 2019
2. Lin DH, Hoelz A
Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction.
1. Prog Biophys Mol Biol - published March 1, 2019
2. Bacolla A, Ye Z, Ahmed Z, Tainer JA
Reciprocal modulation between amyloid precursor protein and synaptic membrane cholesterol revealed by live cell imaging.
1. Neurobiol Dis - published March 1, 2019
2. DelBove CE, Strothman CE, Lazarenko RM, Huang H, Sanders CR, Zhang Q
Simulations suggest a constrictive force is required for Gram-negative bacterial cell division.
1. Nat Commun - published March 1, 2019
2. Nguyen LT, Oikonomou CM, Ding HJ, Kaplan M, Yao Q, Chang YW, Beeby M, Jensen GJ
Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation.
1. Nat Commun - published March 1, 2019
2. Mayer D, Damberger FF, Samarasimhareddy M, Feldmueller M, Vuckovic Z, Flock T, Bauer B, Mutt E, Zosel F, Allain FHT, Standfuss J, Schertler GFX, Deupi X, Sommer ME, Hurevich M, Friedler A, Veprintsev DB
Structural Insight into DNA-Dependent Activation of Human Metalloprotease Spartan.
1. Cell Rep - published March 1, 2019
2. Li F, Raczynska JE, Chen Z, Yu H
Unusual substrate and halide versatility of phenolic halogenase PltM.
1. Nat Commun - published March 1, 2019
2. Mori S, Pang AH, Thamban Chandrika N, Garneau-Tsodikova S, Tsodikov OV
Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output.
1. PLoS Biol - published March 1, 2019
2. Miller CJ, Lou HJ, Simpson C, van de Kooij B, Ha BH, Fisher OS, Pirman NL, Boggon TJ, Rinehart J, Yaffe MB, Linding R, Turk BE
Expression, purification and crystallization of the novel Xenopus tropicalis ALDH16B1, a homologue of human ALDH16A1.
1. Chem Biol Interact - published March 1, 2019
2. Pantouris G, Dioletis E, Chen Y, Thompson DC, Vasiliou V, Lolis EJ
Structural basis of lipopolysaccharide extraction by the LptB2FGC complex.
1. Nature - published March 1, 2019
2. Li Y, Orlando BJ, Liao M
Structural basis of unidirectional export of lipopolysaccharide to the cell surface.
1. Nature - published March 1, 2019
2. Owens TW, Taylor RJ, Pahil KS, Bertani BR, Ruiz N, Kruse AC, Kahne D
The effect of the antisickling compound GBT1118 on the permeability of red blood cells from patients with sickle cell anemia.
1. Physiol Rep - published March 1, 2019
2. Al Balushi H, Dufu K, Rees DC, Brewin JN, Hannemann A, Oksenberg D, Lu DC, Gibson JS
Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity.
1. Cell Chem Biol - published March 1, 2019
2. Ferguson FM, Doctor ZM, Ficarro SB, Browne CM, Marto JA, Johnson JL, Yaron TM, Cantley LC, Kim ND, Sim T, Berberich MJ, Kalocsay M, Sorger PK, Gray NS
How best to use photons.
1. Acta Crystallogr D Struct Biol - published March 1, 2019
2. Winter G, Gildea RJ, Paterson NG, Beale J, Gerstel M, Axford D, Vollmar M, McAuley KE, Owen RL, Flaig R, Ashton AW, Hall DR
Electron Cryotomography of Bacterial Secretion Systems.
1. Microbiol Spectr - published March 1, 2019
2. Oikonomou CM, Jensen GJ
Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries.
1. Cell Chem Biol - published March 1, 2019
2. Moret N, Clark NA, Hafner M, Wang Y, Lounkine E, Medvedovic M, Wang J, Gray N, Jenkins J, Sorger PK
Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome.
1. Cell Chem Biol - published March 1, 2019
2. Rao S, Gurbani D, Du G, Everley RA, Browne CM, Chaikuad A, Li T, Schröder M, Gondi S, Ficarro SB, Sim T, Kim ND, Berberich MJ, Knapp S, Marto JA, Westover KD, Sorger PK, Gray NS
MicroED data collection with SerialEM.
1. Ultramicroscopy - published March 1, 2019
2. de la Cruz MJ, Martynowycz MW, Hattne J, Gonen T