Member Publications

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121 Member Publications for August 2018

Endoplasmic reticulum-to-Golgi transitions upon herpes virus infection.
1. F1000Res - published August 28, 2018
2. Wild P, Kaech A, Schraner EM, Walser L, Ackermann M
Recombinant Purification of the Periplasmic Portion of the LINC Complex.
1. Methods Mol Biol - published August 25, 2018
2. Cruz VE, Schwartz TU
Reconstitution of Clathrin Coat Disassembly for Fluorescence Microscopy and Single-Molecule Analysis.
1. Methods Mol Biol - published August 22, 2018
2. Böcking T, Upadhyayula S, Rapoport I, Capraro BR, Kirchhausen T
In Vitro Transcription Assay to Quantify Effects of H-NS Filaments on RNA Chain Elongation by RNA Polymerase.
1. Methods Mol Biol - published August 16, 2018
2. Boudreau BA, Kotlajich MV, Landick R
Supramolecular assembly of KAT2A with succinyl-CoA for histone succinylation.
1. Cell Discov - published August 16, 2018
2. Wang Y, Guo YR, Xing D, Tao YJ, Lu Z
Methods for Studying the Radical SAM Enzymes in Diphthamide Biosynthesis.
1. Methods Enzymol - published August 12, 2018
2. Dong M, Zhang Y, Lin H
HPLC-Based Enzyme Assays for Sirtuins.
1. Methods Mol Biol - published August 12, 2018
2. Hong JY, Zhang X, Lin H
Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis.
1. Cell - published August 9, 2018
2. Chu N, Salguero AL, Liu AZ, Chen Z, Dempsey DR, Ficarro SB, Alexander WM, Marto JA, Li Y, Amzel LM, Gabelli SB, Cole PA
Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.
1. Nat Commun - published August 9, 2018
2. Kozono S, Lin YM, Seo HS, Pinch B, Lian X, Qiu C, Herbert MK, Chen CH, Tan L, Gao ZJ, Massefski W, Doctor ZM, Jackson BP, Chen Y, Dhe-Paganon S, Lu KP, Zhou XZ
Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection.
1. Cell - published August 9, 2018
2. Saphire EO, Schendel SL, Fusco ML, Gangavarapu K, Gunn BM, Wec AZ, Halfmann PJ, Brannan JM, Herbert AS, Qiu X, Wagh K, He S, Giorgi EE, Theiler J, Pommert KBJ, Krause TB, Turner HL, Murin CD, Pallesen J, Davidson E, Ahmed R, Aman MJ, Bukreyev A, Burton DR, Crowe JE Jr, Davis CW, Georgiou G, Krammer F, Kyratsous CA, Lai JR, Nykiforuk C, Pauly MH, Rijal P, Takada A, Townsend AR, Volchkov V, Walker LM, Wang CI, Zeitlin L, Doranz BJ, Ward AB, Korber B, Kobinger GP, Andersen KG, Kawaoka Y, Alter G, Chandran K, Dye JM, Viral Hemorrhagic Fever Immunotherapeutic Consortium.
The large GTPase atlastin controls ER remodeling around a pathogen vacuole.
1. Commun Integr Biol - published August 8, 2018
2. Steiner B, Weber S, Kaech A, Ziegler U, Hilbi H
Poly(ADP-ribose) polymerase 1 searches DNA via a 'monkey bar' mechanism.
1. Elife - published August 8, 2018
2. Rudolph J, Mahadevan J, Dyer P, Luger K
Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins.
1. Nat Commun - published August 8, 2018
2. Jbara M, Laps S, Morgan M, Kamnesky G, Mann G, Wolberger C, Brik A
A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus.
1. Cell Host Microbe - published August 8, 2018
2. Gunn BM, Yu WH, Karim MM, Brannan JM, Herbert AS, Wec AZ, Halfmann PJ, Fusco ML, Schendel SL, Gangavarapu K, Krause T, Qiu X, He S, Das J, Suscovich TJ, Lai J, Chandran K, Zeitlin L, Crowe JE Jr, Lauffenburger D, Kawaoka Y, Kobinger GP, Andersen KG, Dye JM, Saphire EO, Alter G
Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.
1. Structure - published August 7, 2018
2. Xiong S, Lorenzen K, Couzens AL, Templeton CM, Rajendran D, Mao DYL, Juang YC, Chiovitti D, Kurinov I, Guettler S, Gingras AC, Sicheri F
Crystal Structure of an Unusual Single-Stranded DNA-Binding Protein Encoded by Staphylococcal Cassette Chromosome Elements.
1. Structure - published August 7, 2018
2. Mir-Sanchis I, Pigli YZ, Rice PA
Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain.
1. Structure - published August 7, 2018
2. Emptage RP, Lemmon MA, Ferguson KM, Marmorstein R
Structural Flexibility Enables Alternative Maturation, ARGONAUTE Sorting and Activities of miR168, a Global Gene Silencing Regulator in Plants.
1. Mol Plant - published August 6, 2018
2. Iki T, Cléry A, Bologna NG, Sarazin A, Brosnan CA, Pumplin N, Allain FHT, Voinnet O
Insights into centriole geometry revealed by cryotomography of doublet and triplet centrioles.
1. Elife - published August 6, 2018
2. Greenan GA, Keszthelyi B, Vale RD, Agard DA
Diel rewiring and positive selection of ancient plant proteins enabled evolution of CAM photosynthesis in Agave.
1. BMC Genomics - published August 6, 2018
2. Yin H, Guo HB, Weston DJ, Borland AM, Ranjan P, Abraham PE, Jawdy SS, Wachira J, Tuskan GA, Tschaplinski TJ, Wullschleger SD, Guo H, Hettich RL, Gross SM, Wang Z, Visel A, Yang X
Hippo/YAP signaling pathway mitigates blood-brain barrier disruption after cerebral ischemia/reperfusion injury.
1. Behav Brain Res - published August 6, 2018
2. Gong P, Zhang Z, Zou C, Tian Q, Chen X, Hong M, Liu X, Chen Q, Xu Z, Li M, Wang J
In silico fragment-based drug design with SEED.
1. Eur J Med Chem - published August 5, 2018
2. Marchand JR, Caflisch A
Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain.
1. Biosci Rep - published August 3, 2018
2. Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR
Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins.
1. J Biol Chem - published August 3, 2018
2. Patel S, Barkell AM, Gupta D, Strong SL, Bruton S, Muskett FW, Addis PW, Renshaw PS, Slocombe PM, Doyle C, Clargo A, Taylor RJ, Prosser CE, Henry AJ, Robinson MK, Waters LC, Holdsworth G, Carr MD
Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity.
1. J Biol Chem - published August 3, 2018
2. Elnatan D, Agard DA
Reversible covalent direct thrombin inhibitors.
1. PLoS One - published August 3, 2018
2. Sivaraja M, Pozzi N, Rienzo M, Lin K, Shiau TP, Clemens DM, Igoudin L, Zalicki P, Chang SS, Estiarte MA, Short KM, Williams DC, Datta A, Di Cera E, Kita DB
Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.
1. Cell - published August 3, 2018
2. Qu Q, Takahashi YH, Yang Y, Hu H, Zhang Y, Brunzelle JS, Couture JF, Shilatifard A, Skiniotis G
Structures reveal opening of the store-operated calcium channel Orai.
1. Elife - published August 3, 2018
2. Hou X, Burstein SR, Long SB
Engineered CRISPR-Cas9 nuclease with expanded targeting space.
1. Science - published August 3, 2018
2. Nishimasu H, Shi X, Ishiguro S, Gao L, Hirano S, Okazaki S, Noda T, Abudayyeh OO, Gootenberg JS, Mori H, Oura S, Holmes B, Tanaka M, Seki M, Hirano H, Aburatani H, Ishitani R, Ikawa M, Yachie N, Zhang F, Nureki O
CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.
1. EMBO J - published August 3, 2018
2. Chen SH, Jang GM, Hüttenhain R, Gordon DE, Du D, Newton BW, Johnson JR, Hiatt J, Hultquist JF, Johnson TL, Liu YL, Burton LA, Ye J, Reichermeier KM, Stroud RM, Marson A, Debnath J, Gross JD, Krogan NJ
CRISPR-Cas guides the future of genetic engineering.
1. Science - published August 3, 2018
2. Knott GJ, Doudna JA
Single-particle cryo-EM-How did it get here and where will it go.
1. Science - published August 3, 2018
2. Cheng Y
Geochemical Continuity and Catalyst/Cofactor Replacement in the Emergence and Evolution of Life.
1. Angew Chem Int Ed Engl - published August 3, 2018
2. Fontecilla-Camps JC
Configurational and Conformational Equilibria of N6-(2-Deoxy-d-erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5- N-methylformamidopyrimidine (MeFapy-dG) Lesion in DNA.
1. Chem Res Toxicol - published August 3, 2018
2. Bamberger SN, Malik CK, Voehler MW, Brown SK, Pan H, Johnson-Salyard TL, Rizzo CJ, Stone MP
Response to Comment on "Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water".
1. Science - published August 3, 2018
2. Riback JA, Bowman MA, Zmyslowski A, Knoverek CR, Jumper J, Kaye EB, Freed KF, Clark PL, Sosnick TR
Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography.
1. iScience - published August 3, 2018
2. Siegmund SE, Grassucci R, Carter SD, Barca E, Farino ZJ, Juanola-Falgarona M, Zhang P, Tanji K, Hirano M, Schon EA, Frank J, Freyberg Z
Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface.
1. Free Radic Biol Med - published August 2, 2018
2. Wert KJ, Velez G, Cross MR, Wagner BA, Teoh-Fitzgerald ML, Buettner GR, McAnany JJ, Olivier A, Tsang SH, Harper MM, Domann FE, Bassuk AG, Mahajan VB
Discovery and engineering of enhanced SUMO protease enzymes.
1. J Biol Chem - published August 2, 2018
2. Lau YK, Baytshtok V, Howard TA, Fiala BM, Johnson JM, Carter LP, Baker D, Lima CD, Bahl CD
Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein.
1. Immunity - published August 2, 2018
2. Gilchuk P, Kuzmina N, Ilinykh PA, Huang K, Gunn BM, Bryan A, Davidson E, Doranz BJ, Turner HL, Fusco ML, Bramble MS, Hoff NA, Binshtein E, Kose N, Flyak AI, Flinko R, Orlandi C, Carnahan R, Parrish EH, Sevy AM, Bombardi RG, Singh PK, Mukadi P, Muyembe-Tamfum JJ, Ohi MD, Saphire EO, Lewis GK, Alter G, Ward AB, Rimoin AW, Bukreyev A, Crowe JE Jr
Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions.
1. Development - published August 2, 2018
2. Liu X, Gu X, Ma W, Oxendine M, Gil HJ, Davis GE, Cleaver O, Oliver G
Cysteine-mediated decyanation of vitamin B12 by the predicted membrane transporter BtuM.
1. Nat Commun - published August 2, 2018
2. Rempel S, Colucci E, de Gier JW, Guskov A, Slotboom DJ
Direct imaging of uncoated biological samples enables correlation of super-resolution and electron microscopy data.
1. Sci Rep - published August 2, 2018
2. Mateos JM, Barmettler G, Doehner J, Kaech A, Ziegler U
Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated RPSA exons.
1. Proc Natl Acad Sci U S A - published August 2, 2018
2. Bolze A, Boisson B, Bosch B, Antipenko A, Bouaziz M, Sackstein P, Chaker-Margot M, Barlogis V, Briggs T, Colino E, Elmore AC, Fischer A, Genel F, Hewlett A, Jedidi M, Kelecic J, Krüger R, Ku CL, Kumararatne D, Lefevre-Utile A, Loughlin S, Mahlaoui N, Markus S, Garcia JM, Nizon M, Oleastro M, Pac M, Picard C, Pollard AJ, Rodriguez-Gallego C, Thomas C, Von Bernuth H, Worth A, Meyts I, Risolino M, Selleri L, Puel A, Klinge S, Abel L, Casanova JL
Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies.
1. Immunity - published August 2, 2018
2. Duan H, Chen X, Boyington JC, Cheng C, Zhang Y, Jafari AJ, Stephens T, Tsybovsky Y, Kalyuzhniy O, Zhao P, Menis S, Nason MC, Normandin E, Mukhamedova M, DeKosky BJ, Wells L, Schief WR, Tian M, Alt FW, Kwong PD, Mascola JR
DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions.
1. Immunity - published August 2, 2018
2. Stadtmueller BM, Bridges MD, Dam KM, Lerch MT, Huey-Tubman KE, Hubbell WL, Bjorkman PJ
Reply to Pandey et al.: Understanding the efficacy of a potential antiretroviral drug candidate in humanized mouse model of HIV infection.
1. Proc Natl Acad Sci U S A - published August 2, 2018
2. Kudalkar SN, Beloor J, Quijano E, Spasov KA, Lee WG, Cisneros JA, Saltzman WM, Kumar P, Jorgensen WL, Anderson KS
Structure of the mammalian TRPM7, a magnesium channel required during embryonic development.
1. Proc Natl Acad Sci U S A - published August 2, 2018
2. Duan J, Li Z, Li J, Hulse RE, Santa-Cruz A, Valinsky WC, Abiria SA, Krapivinsky G, Zhang J, Clapham DE
Synthesis of α-Borylated Ketones by Regioselective Wacker Oxidation of Alkenylboronates.
1. Org Lett - published August 2, 2018
2. Corless VB, Holownia A, Foy H, Mendoza-Sanchez R, Adachi S, Dudding T, Yudin AK
Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells.
1. Elife - published August 2, 2018
2. Del Mármol JI, Touhara KK, Croft G, MacKinnon R
Dual Targeting of Innate and Adaptive Checkpoints on Tumor Cells Limits Immune Evasion.
1. Cell Rep - published August 2, 2018
2. Liu X, Liu L, Ren Z, Yang K, Xu H, Luan Y, Fu K, Guo J, Peng H, Zhu M, Fu YX
G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β₂-adrenergic receptor.
1. Sci Signal - published August 2, 2018
2. Choi M, Staus DP, Wingler LM, Ahn S, Pani B, Capel WD, Lefkowitz RJ
TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells.
1. Neuron - published August 2, 2018
2. Pan B, Akyuz N, Liu XP, Asai Y, Nist-Lund C, Kurima K, Derfler BH, György B, Limapichat W, Walujkar S, Wimalasena LN, Sotomayor M, Corey DP, Holt JR
Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway.
1. Org Biomol Chem - published August 2, 2018
2. Newmister SA, Romminger S, Schmidt JJ, Williams RM, Smith JL, Berlinck RGS, Sherman DH
Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation.
1. Science - published August 2, 2018
2. Vemu A, Szczesna E, Zehr EA, Spector JO, Grigorieff N, Deaconescu AM, Roll-Mecak A
Structure of a Novel Dimeric SET Domain Methyltransferase that Regulates Cell Motility.
1. J Mol Biol - published August 2, 2018
2. Pivovarova Y, Liu J, Lesigang J, Koldyka O, Rauschmeier R, Hu K, Dong G
Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins.
1. EMBO Rep - published August 2, 2018
2. Morrow ME, Morgan MT, Clerici M, Growkova K, Yan M, Komander D, Sixma TK, Simicek M, Wolberger C
Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
1. Nat Med - published August 2, 2018
2. Hunter RW, Hughey CC, Lantier L, Sundelin EI, Peggie M, Zeqiraj E, Sicheri F, Jessen N, Wasserman DH, Sakamoto K
Modelling the cost-effectiveness of pay-for-performance in primary care in the UK.
1. BMC Med - published August 2, 2018
2. Pandya A, Doran T, Zhu J, Walker S, Arntson E, Ryan AM
Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites.
1. Cell Rep - published August 2, 2018
2. Zeiske T, Baburajendran N, Kaczynska A, Brasch J, Palmer AG 3rd, Shapiro L, Honig B, Mann RS
Pathogenic TFG Mutations Underlying Hereditary Spastic Paraplegia Impair Secretory Protein Trafficking and Axon Fasciculation.
1. Cell Rep - published August 2, 2018
2. Slosarek EL, Schuh AL, Pustova I, Johnson A, Bird J, Johnson M, Frankel EB, Bhattacharya N, Hanna MG, Burke JE, Ruhl DA, Quinney K, Block S, Peotter JL, Chapman ER, Sheets MD, Butcher SE, Stagg SM, Audhya A
Biochemical and pathological changes result from mutated Caveolin-3 in muscle.
1. Skelet Muscle - published August 2, 2018
2. González Coraspe JA, Weis J, Anderson ME, Münchberg U, Lorenz K, Buchkremer S, Carr S, Zahedi RP, Brauers E, Michels H, Sunada Y, Lochmüller H, Campbell KP, Freier E, Hathazi D, Roos A
A feed forward loop enforces YAP/TAZ signaling during tumorigenesis.
1. Nat Commun - published August 2, 2018
2. Gill MK, Christova T, Zhang YY, Gregorieff A, Zhang L, Narimatsu M, Song S, Xiong S, Couzens AL, Tong J, Krieger JR, Moran MF, Zlotta AR, van der Kwast TH, Gingras AC, Sicheri F, Wrana JL, Attisano L
A long-lived Aβ oligomer resistant to fibrillization.
1. Biopolymers - published August 1, 2018
2. Nick M, Wu Y, Schmidt NW, Prusiner SB, Stöhr J, DeGrado WF
Efficacy and Safety of ATX-101 by Treatment Session: Pooled Analysis of Data From the Phase 3 REFINE Trials.
1. Aesthet Surg J - published August 1, 2018
2. Dayan SH, Schlessinger J, Beer K, Donofrio LM, Jones DH, Humphrey S, Carruthers J, Lizzul PF, Gross TM, Beddingfield FC 3rd, Somogyi C
Segmental isotopic labeling by asparaginyl endopeptidase-mediated protein ligation.
1. J Biomol NMR - published August 1, 2018
2. Mikula KM, Krumwiede L, Plückthun A, Iwaï H
The tubulin code in neuronal polarity.
1. Curr Opin Neurobiol - published August 1, 2018
2. Park JH, Roll-Mecak A
Translocation of lipoproteins to the surface of gram negative bacteria.
1. Curr Opin Struct Biol - published August 1, 2018
2. Hooda Y, Moraes TF
Membrane properties that shape the evolution of membrane enzymes.
1. Curr Opin Struct Biol - published August 1, 2018
2. Sanders CR, Hutchison JM
Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis.
1. FASEB J - published August 1, 2018
2. Mbanefo EC, Le L, Pennington LF, Odegaard JI, Jardetzky TS, Alouffi A, Falcone FH, Hsieh MH
Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.
1. J Struct Biol - published August 1, 2018
2. Liu C, Yuan M, Xu X, Wang L, Keatinge-Clay AT, Deng Z, Lin S, Zheng J
Mechanistic insights into ER-associated protein degradation.
1. Curr Opin Cell Biol - published August 1, 2018
2. Wu X, Rapoport TA
HTRA1, an age-related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1.
1. Aging Cell - published August 1, 2018
2. Lin MK, Yang J, Hsu CW, Gore A, Bassuk AG, Brown LM, Colligan R, Sengillo JD, Mahajan VB, Tsang SH
Five Residues in the Apical Loop of the Respiratory Syncytial Virus Fusion Protein F₂ Subunit Are Critical for Its Fusion Activity.
1. J Virol - published August 1, 2018
2. Hicks SN, Chaiwatpongsakorn S, Costello HM, McLellan JS, Ray W, Peeples ME
CRISPR GENOME SURGERY IN THE RETINA IN LIGHT OF OFF-TARGETING.
1. Retina - published August 1, 2018
2. Cho GY, Schaefer KA, Bassuk AG, Tsang SH, Mahajan VB
Small-Molecule Positive Allosteric Modulators of the β₂-Adrenoceptor Isolated from DNA-Encoded Libraries.
1. Mol Pharmacol - published August 1, 2018
2. Ahn S, Pani B, Kahsai AW, Olsen EK, Husemoen G, Vestergaard M, Jin L, Zhao S, Wingler LM, Rambarat PK, Simhal RK, Xu TT, Sun LD, Shim PJ, Staus DP, Huang LY, Franch T, Chen X, Lefkowitz RJ
Deferoxamine-induced electronegative ERG responses.
1. Doc Ophthalmol - published August 1, 2018
2. Jauregui R, Park KS, Bassuk AG, Mahajan VB, Tsang SH
Autosomal-dominant early-onset spastic paraparesis with brain calcification due to IFIH1 gain-of-function.
1. Hum Mutat - published August 1, 2018
2. Ruaud L, Rice GI, Cabrol C, Piard J, Rodero M, van Eyk L, Boucher-Brischoux E, de Noordhout AM, Maré R, Scalais E, Pauly F, Debray FG, Dobyns W, Uggenti C, Park JW, Hur S, Livingston JH, Crow YJ, Van Maldergem L
Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP).
1. Antiviral Res - published August 1, 2018
2. Bauer L, Ferla S, Head SA, Bhat S, Pasunooti KK, Shi WQ, Albulescu L, Liu JO, Brancale A, van Kuppeveld FJM, Strating JRPM
Tissue clearing of both hard and soft tissue organs with the PEGASOS method.
1. Cell Res - published August 1, 2018
2. Jing D, Zhang S, Luo W, Gao X, Men Y, Ma C, Liu X, Yi Y, Bugde A, Zhou BO, Zhao Z, Yuan Q, Feng JQ, Gao L, Ge WP, Zhao H
Solar Water Splitting with a Hydrogenase Integrated in Photoelectrochemical Tandem Cells.
1. Angew Chem Int Ed Engl - published August 1, 2018
2. Nam DH, Zhang JZ, Andrei V, Kornienko N, Heidary N, Wagner A, Nakanishi K, Sokol KP, Slater B, Zebger I, Hofmann S, Fontecilla-Camps JC, Park CB, Reisner E
Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992.
1. Mol Pharmacol - published August 1, 2018
2. Kharade SV, Kurata H, Bender AM, Blobaum AL, Figueroa EE, Duran A, Kramer M, Days E, Vinson P, Flores D, Satlin LM, Meiler J, Weaver CD, Lindsley CW, Hopkins CR, Denton JS
Acyclic peptides incorporating the d-Phe-2-Abz turn motif: Investigations on antimicrobial activity and propensity to adopt β-hairpin conformations.
1. J Pept Sci - published August 1, 2018
2. Cameron AJ, Varnava KG, Edwards PJB, Harjes E, Sarojini V
Evolution of New Delhi metallo-β-lactamase (NDM) in the clinic: Effects of NDM mutations on stability, zinc affinity, and mono-zinc activity.
1. J Biol Chem - published August 1, 2018
2. Cheng Z, Thomas PW, Ju L, Bergstrom A, Mason K, Clayton D, Miller C, Bethel CR, VanPelt J, Tierney DL, Page RC, Bonomo RA, Fast W, Crowder MW
Segmental isotope labelling and solid-state NMR of a 12 × 59 kDa motor protein: identification of structural variability.
1. J Biomol NMR - published August 1, 2018
2. Wiegand T, Cadalbert R, von Schroetter C, Allain FH, Meier BH
Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress.
1. Cell Death Differ - published August 1, 2018
2. Lam M, Lawrence DA, Ashkenazi A, Walter P
A cluster of residues in the lipopolysaccharide exporter that selects substrate variants for transport to the outer membrane.
1. Mol Microbiol - published August 1, 2018
2. Bertani BR, Taylor RJ, Nagy E, Kahne D, Ruiz N
Structural basis for the regulation of inositol trisphosphate receptors by Ca²⁺ and IP₃.
1. Nat Struct Mol Biol - published August 1, 2018
2. Paknejad N, Hite RK
GPCR signaling: conformational activation of arrestins.
1. Cell Res - published August 1, 2018
2. Kahsai AW, Pani B, Lefkowitz RJ
Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability.
1. Nature - published August 1, 2018
2. Iglesias N, Currie MA, Jih G, Paulo JA, Siuti N, Kalocsay M, Gygi SP, Moazed D
Identification of a diphtheria toxin-like gene family beyond the Corynebacterium genus.
1. FEBS Lett - published August 1, 2018
2. Mansfield MJ, Sugiman-Marangos SN, Melnyk RA, Doxey AC
Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension.
1. Nat Struct Mol Biol - published August 1, 2018
2. Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks J, Baron JL, Nishimura SL, Cheng Y
DNA melting initiates the RAG catalytic pathway.
1. Nat Struct Mol Biol - published August 1, 2018
2. Ru H, Mi W, Zhang P, Alt FW, Schatz DG, Liao M, Wu H
Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α).
1. Proc Natl Acad Sci U S A - published August 1, 2018
2. Reshetnyak AV, Mohanty J, Tomé F, Puleo DE, Plotnikov AN, Ahmed M, Kaur N, Poliakov A, Cinnaiyan AM, Lax I, Schlessinger J
A new twist on V(D)J recombination.
1. Nat Struct Mol Biol - published August 1, 2018
2. Dyda F, Rice PA
Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome.
1. Elife - published August 1, 2018
2. Donovan KA, An J, Nowak RP, Yuan JC, Fink EC, Berry BC, Ebert BL, Fischer ES
Production and transplantation of bioengineered lung into a large-animal model.
1. Sci Transl Med - published August 1, 2018
2. Nichols JE, La Francesca S, Niles JA, Vega SP, Argueta LB, Frank L, Christiani DC, Pyles RB, Himes BE, Zhang R, Li S, Sakamoto J, Rhudy J, Hendricks G, Begarani F, Liu X, Patrikeev I, Pal R, Usheva E, Vargas G, Miller A, Woodson L, Wacher A, Grimaldo M, Weaver D, Mlcak R, Cortiella J
Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice.
1. PLoS Pathog - published August 1, 2018
2. Koestner W, Spanier J, Klause T, Tegtmeyer PK, Becker J, Herder V, Borst K, Todt D, Lienenklaus S, Gerhauser I, Detje CN, Geffers R, Langereis MA, Vondran FWR, Yuan Q, van Kuppeveld FJM, Ott M, Staeheli P, Steinmann E, Baumgärtner W, Wacker F, Kalinke U
FDM 3D Printing of High-Pressure, Heat-Resistant, Transparent Microfluidic Devices.
1. Anal Chem - published August 1, 2018
2. Romanov V, Samuel R, Chaharlang M, Jafek AR, Frost A, Gale BK
The rise of neutron cryo-crystallography.
1. Acta Crystallogr D Struct Biol - published August 1, 2018
2. Kwon H, Langan PS, Coates L, Raven EL, Moody PCE
Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM.
1. Nature - published August 1, 2018
2. Kummer E, Leibundgut M, Rackham O, Lee RG, Boehringer D, Filipovska A, Ban N
Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes.
1. Annu Rev Cell Dev Biol - published August 1, 2018
2. McCullough J, Frost A, Sundquist WI
DNA-Corralled Nanodiscs for the Structural and Functional Characterization of Membrane Proteins and Viral Entry.
1. J Am Chem Soc - published August 1, 2018
2. Zhao Z, Zhang M, Hogle JM, Shih WM, Wagner G, Nasr ML
A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers.
1. Nat Commun - published August 1, 2018
2. Gettinger SN, Choi J, Mani N, Sanmamed MF, Datar I, Sowell R, Du VY, Kaftan E, Goldberg S, Dong W, Zelterman D, Politi K, Kavathas P, Kaech S, Yu X, Zhao H, Schlessinger J, Lifton R, Rimm DL, Chen L, Herbst RS, Schalper KA
Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay.
1. BMC Biol - published August 1, 2018
2. Koszela J, Pham NT, Evans D, Mann S, Perez-Pi I, Shave S, Ceccarelli DFJ, Sicheri F, Tyers M, Auer M
Kinetic analysis of the influenza A virus HA/NA balance reveals contribution of NA to virus-receptor binding and NA-dependent rolling on receptor-containing surfaces.
1. PLoS Pathog - published August 1, 2018
2. Guo H, Rabouw H, Slomp A, Dai M, van der Vegt F, van Lent JWM, McBride R, Paulson JC, de Groot RJ, van Kuppeveld FJM, de Vries E, de Haan CAM
Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy.
1. J Immunol - published August 1, 2018
2. Spangler JB, Trotta E, Tomala J, Peck A, Young TA, Savvides CS, Silveria S, Votavova P, Salafsky J, Pande VS, Kovar M, Bluestone JA, Garcia KC
Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
1. Nucleic Acids Res - published August 1, 2018
2. Harp JM, Guenther DC, Bisbe A, Perkins L, Matsuda S, Bommineni GR, Zlatev I, Foster DJ, Taneja N, Charisse K, Maier MA, Rajeev KG, Manoharan M, Egli M
Crystal Structure of a ligand-bound LacY-Nanobody Complex.
1. Proc Natl Acad Sci U S A - published August 1, 2018
2. Kumar H, Finer-Moore JS, Jiang X, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM
Structural basis for Scc3-dependent cohesin recruitment to chromatin.
1. Elife - published August 1, 2018
2. Li Y, Muir KW, Bowler MW, Metz J, Haering CH, Panne D
Antibody Repertoires to the Same Ebola Vaccine Antigen Are Differentially Affected by Vaccine Vectors.
1. Cell Rep - published August 1, 2018
2. Meyer M, Yoshida A, Ramanathan P, Saphire EO, Collins PL, Crowe JE Jr, Samal S, Bukreyev A
Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors.
1. Cell Rep - published August 1, 2018
2. Kuzmina NA, Younan P, Gilchuk P, Santos RI, Flyak AI, Ilinykh PA, Huang K, Lubaki NM, Ramanathan P, Crowe JE Jr, Bukreyev A
Cryo-EM structure of the insect olfactory receptor Orco.
1. Nature - published August 1, 2018
2. Butterwick JA, Del Mármol J, Kim KH, Kahlson MA, Rogow JA, Walz T, Ruta V
Missense mutation in SLIT2 associated with congenital myopia, anisometropia, connective tissue abnormalities, and obesity.
1. Orphanet J Rare Dis - published August 1, 2018
2. Liu KY, Sengillo JD, Velez G, Jauregui R, Sakai LY, Maumenee IH, Bassuk AG, Mahajan VB, Tsang SH
A Novel Polar Core and Weakly Fixed C-Tail in Squid Arrestin Provide New Insight into Interaction with Rhodopsin.
1. J Mol Biol - published August 1, 2018
2. Bandyopadhyay A, Van Eps N, Eger BT, Rauscher S, Yedidi RS, Moroni T, West GM, Robinson KA, Griffin PR, Mitchell J, Ernst OP
Author Correction: A mechanism for CO regulation of ion channels.
1. Nat Commun - published August 1, 2018
2. Kapetanaki SM, Burton MJ, Basran J, Uragami C, Moody PCE, Mitcheson JS, Schmid R, Davies NW, Dorlet P, Vos MH, Storey NM, Raven E
On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies.
1. J Biomol NMR - published August 1, 2018
2. Clark L, Dikiy I, Rosenbaum DM, Gardner KH
Asymmetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap.
1. PLoS Pathog - published August 1, 2018
2. Ilinykh PA, Santos RI, Gunn BM, Kuzmina NA, Shen X, Huang K, Gilchuk P, Flyak AI, Younan P, Alter G, Crowe JE Jr, Bukreyev A
Nucleoside triphosphate cosubstrates control the substrate profile and efficiency of aminoglycoside 3'-O-phosphotransferase type IIa.
1. Medchemcomm - published August 1, 2018
2. Holbrook SYL, Gentry MS, Tsodikov OV, Garneau-Tsodikova S
A structural perspective on tail-anchored protein biogenesis by the GET pathway.
1. Curr Opin Struct Biol - published August 1, 2018
2. Mateja A, Keenan RJ
Spectroscopic and metal binding properties of a de novo metalloprotein binding a tetrazinc cluster.
1. Biopolymers - published August 1, 2018
2. Chino M, Zhang SQ, Pirro F, Leone L, Maglio O, Lombardi A, DeGrado WF
The histone chaperone FACT modulates nucleosome structure by tethering its components.
1. Life Sci Alliance - published August 1, 2018
2. Wang T, Liu Y, Edwards G, Krzizike D, Scherman H, Luger K