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109 Member Publications for June 2018

Differential Regulation of Escherichia coli fim Genes following Binding to Mannose Receptors.
1. J Pathog - published June 29, 2018
2. Schwan WR, Beck MT, Hung CS, Hultgren SJ
A pseudo-receiver domain in Atg32 is required for mitophagy.
1. Autophagy - published June 19, 2018
2. Xia X, Katzenell S, Reinhart EF, Bauer KM, Pellegrini M, Ragusa MJ
The Retrovirus Capsid Core.
1. Subcell Biochem - published June 15, 2018
2. Zhang W, Mendonça LM, Mansky LM
A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor.
1. J Biol Chem - published June 8, 2018
2. Tretter JY, Schorpp K, Luxenburger E, Trambauer J, Steiner H, Hadian K, Gires O, Niessing D
Assembly of human C-terminal binding protein (CtBP) into tetramers.
1. J Biol Chem - published June 8, 2018
2. Bellesis AG, Jecrois AM, Hayes JA, Schiffer CA, Royer WE Jr
Translation of CRISPR Genome Surgery to the Bedside for Retinal Diseases.
1. Front Cell Dev Biol - published June 8, 2018
2. Xu CL, Cho GY, Sengillo JD, Park KS, Mahajan VB, Tsang SH
Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.
1. Elife - published June 8, 2018
2. Miles TF, Spiess K, Jude KM, Tsutsumi N, Burg JS, Ingram JR, Waghray D, Hjorto GM, Larsen O, Ploegh HL, Rosenkilde MM, Garcia KC
An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.
1. Elife - published June 7, 2018
2. Keedy DA, Hill ZB, Biel JT, Kang E, Rettenmaier TJ, Brandao-Neto J, Pearce NM, von Delft F, Wells JA, Fraser JS
Inhibition of phosphodiesterase 2 by Bay 60-7550 decreases ethanol intake and preference in mice.
1. Psychopharmacology (Berl) - published June 7, 2018
2. Shi J, Liu H, Pan J, Chen J, Zhang N, Liu K, Fei N, O'Donnell JM, Zhang HT, Xu Y
MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.
1. Mol Cell - published June 7, 2018
2. Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown NW Jr, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE
Role of Liquid-Liquid Phase Separation in Assembly of Elastin and Other Extracellular Matrix Proteins.
1. J Mol Biol - published June 7, 2018
2. Muiznieks LD, Sharpe S, Pomès R, Keeley FW
Novobiocin Enhances Polymyxin Activity by Stimulating Lipopolysaccharide Transport.
1. J Am Chem Soc - published June 6, 2018
2. Mandler MD, Baidin V, Lee J, Pahil KS, Owens TW, Kahne D
A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action.
1. Neuron - published June 6, 2018
2. Stoeber M, Jullié D, Lobingier BT, Laeremans T, Steyaert J, Schiller PW, Manglik A, von Zastrow M
FcpB Is a Surface Filament Protein of the Endoflagellum Required for the Motility of the Spirochete Leptospira.
1. Front Cell Infect Microbiol - published June 6, 2018
2. Wunder EA Jr, Slamti L, Suwondo DN, Gibson KH, Shang Z, Sindelar CV, Trajtenberg F, Buschiazzo A, Ko AI, Picardeau M
Vms1p is a release factor for the ribosome-associated quality control complex.
1. Nat Commun - published June 6, 2018
2. Zurita Rendón O, Fredrickson EK, Howard CJ, Van Vranken J, Fogarty S, Tolley ND, Kalia R, Osuna BA, Shen PS, Hill CP, Frost A, Rutter J
Determinants of human Glucokinase activation and implications for small molecule allosteric control.
1. Biochim Biophys Acta - published June 6, 2018
2. Li Q, Gakhar L, Ashley Spies M
Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28.
1. Cell Rep - published June 5, 2018
2. Wang L, Rowe RG, Jaimes A, Yu C, Nam Y, Pearson DS, Zhang J, Xie X, Marion W, Heffron GJ, Daley GQ, Sliz P
Type 1 Does The Two-Step: Type 1 Secretion Substrates With A Functional Periplasmic Intermediate.
1. J Bacteriol - published June 4, 2018
2. Smith TJ, Sondermann H, O'Toole GA
Cyclin A Turns on Bora to Light the Path to Mitosis.
1. Dev Cell - published June 4, 2018
2. Zheng G, Yu H
Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations.
1. Cell - published June 3, 2018
2. Chen B, Li Y, Yu B, Zhang Z, Brommer B, Williams PR, Liu Y, Hegarty SV, Zhou S, Zhu J, Guo H, Lu Y, Zhang Y, Gu X, He Z
Noncanonical Radical SAM Enzyme Chemistry Learned from Diphthamide Biosynthesis.
1. Biochemistry - published June 2, 2018
2. Dong M, Zhang Y, Lin H
StpA and Hha stimulate pausing by RNA polymerase by promoting DNA-DNA bridging of H-NS filaments.
1. Nucleic Acids Res - published June 2, 2018
2. Boudreau BA, Hron DR, Qin L, van der Valk RA, Kotlajich MV, Dame RT, Landick R
Evidence That Nucleophile Deprotonation Exceeds Bond Formation in the HDV Ribozyme Transition State.
1. Biochemistry - published June 2, 2018
2. Lu J, Koo SC, Weissman BP, Harris ME, Li NS, Piccirilli JA
Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors.
1. Proc Natl Acad Sci U S A - published June 2, 2018
2. Zhang G, Baidin V, Pahil KS, Moison E, Tomasek D, Ramadoss NS, Chatterjee AK, McNamara CW, Young TS, Schultz PG, Meredith TC, Kahne D
Cryo-EM structure of the cytoplasmic domain of murine transient receptor potential cation channel subfamily C member 6 (TRPC6).
1. J Biol Chem - published June 2, 2018
2. Azumaya CM, Sierra-Valdez F, Cordero-Morales JF, Nakagawa T
Structure and Function of the Transmembrane Domain of NsaS, an Antibiotic Sensing Histidine Kinase in Staphylococcus aureus.
1. J Am Chem Soc - published June 2, 2018
2. Bhate MP, Lemmin T, Kuenze G, Mensa B, Ganguly S, Peters JM, Schmidt N, Pelton JG, Gross CA, Meiler J, DeGrado WF
The structure of urease inactivated by Ag(i): a new paradigm for enzyme inhibition by heavy metals.
1. Dalton Trans - published June 2, 2018
2. Mazzei L, Cianci M, Gonzalez Vara A, Ciurli S
The Yin and Yang of SagS: Distinct Residues in the HmsP Domain of SagS Independently Regulate Biofilm Formation and Biofilm Drug Tolerance.
1. mSphere - published June 2, 2018
2. Dingemans J, Poudyal B, Sondermann H, Sauer K
Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope.
1. Science - published June 2, 2018
2. Imkeller K, Scally SW, Bosch A, Martí GP, Costa G, Triller G, Murugan R, Renna V, Jumaa H, Kremsner PG, Sim BKL, Hoffman SL, Mordmüller B, Levashina EA, Julien JP, Wardemann H
Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli.
1. Proc Natl Acad Sci U S A - published June 2, 2018
2. Zheng S, Sham LT, Rubino FA, Brock KP, Robins WP, Mekalanos JJ, Marks DS, Bernhardt TG, Kruse AC
Atomic Force Microscopy Identifying Fuel Pyrolysis Products and Directing the Synthesis of Analytical Standards.
1. J Am Chem Soc - published June 2, 2018
2. Fatayer S, Poddar NB, Quiroga S, Schulz F, Schuler B, Kalpathy SV, Meyer G, Pérez D, Guitián E, Peña D, Wornat MJ, Gross L
Structure-based discovery of selective BRPF1 bromodomain inhibitors.
1. Eur J Med Chem - published June 2, 2018
2. Zhu J, Zhou C, Caflisch A
A Rich Man, Poor Man Story of S-Adenosylmethionine and Cobalamin Revisited.
1. Annu Rev Biochem - published June 2, 2018
2. Bridwell-Rabb J, Grell TAJ, Drennan CL
Correlation of CRM1-NES affinity with nuclear export activity.
1. Mol Biol Cell - published June 2, 2018
2. Fu SC, Fung HYJ, Cağatay T, Baumhardt J, Chook YM
The Molecular Basis of G Protein-Coupled Receptor Activation.
1. Annu Rev Biochem - published June 2, 2018
2. Weis WI, Kobilka BK
Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor.
1. Elife - published June 2, 2018
2. Livingston KE, Mahoney JP, Manglik A, Sunahara RK, Traynor JR
Scc2 Is a Potent Activator of Cohesin's ATPase that Promotes Loading by Binding Scc1 without Pds5.
1. Mol Cell - published June 2, 2018
2. Petela NJ, Gligoris TG, Metson J, Lee BG, Voulgaris M, Hu B, Kikuchi S, Chapard C, Chen W, Rajendra E, Srinivisan M, Yu H, Löwe J, Nasmyth KA
Publisher Correction: Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
1. Nature - published June 2, 2018
2. Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE
A uniform cloning platform for mycobacterial genetics and protein production.
1. Sci Rep - published June 2, 2018
2. Arnold FM, Hohl M, Remm S, Koliwer-Brandl H, Adenau S, Chusri S, Sander P, Hilbi H, Seeger MA
Contribution of the gp120 V3 loop to envelope glycoprotein trimer stability in primate immunodeficiency viruses.
1. Virology - published June 2, 2018
2. Bowder D, Hollingsead H, Durst K, Hu D, Wei W, Wiggins J, Medjahed H, Finzi A, Sodroski J, Xiang SH
Role of Antibodies in Protection Against Ebola Virus in Nonhuman Primates Immunized With Three Vaccine Platforms.
1. J Infect Dis - published June 2, 2018
2. Warfield KL, Howell KA, Vu H, Geisbert J, Wong G, Shulenin S, Sproule S, Holtsberg FW, Leung DW, Amarasinghe GK, Swenson DL, Bavari S, Kobinger GP, Geisbert TW, Aman MJ
Inhibition of BET bromodomain proteins with GS-5829 and GS-626510 in Uterine Serous Carcinoma, a biologically aggressive variant of Endometrial Cancer.
1. Clin Cancer Res - published June 2, 2018
2. Bonazzoli E, Predolini F, Cocco E, Bellone S, Altwerger G, Menderes G, Zammataro L, Bianchi A, Pettinella F, Riccio F, Han C, Yadav G, Lopez S, Manzano A, Manara P, Buza N, Hui P, Wong S, Litkouhi B, Ratner E, Silasi DA, Huang GS, Azodi M, Schwartz PE, Schlessinger J, Santin AD
Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA.
1. Nat Commun - published June 2, 2018
2. Maiti A, Myint W, Kanai T, Delviks-Frankenberry K, Sierra Rodriguez C, Pathak VK, Schiffer CA, Matsuo H
A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.
1. Nat Med - published June 2, 2018
2. Trotta E, Bessette PH, Silveria SL, Ely LK, Jude KM, Le DT, Holst CR, Coyle A, Potempa M, Lanier LL, Garcia KC, Crellin NK, Rondon IJ, Bluestone JA
Defining distance restraints in HADDOCK.
1. Nat Protoc - published June 2, 2018
2. Bonvin AMJJ, Karaca E, Kastritis PL, Rodrigues JPGLM
Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
1. Sci Rep - published June 2, 2018
2. Omoto S, Speranzini V, Hashimoto T, Noshi T, Yamaguchi H, Kawai M, Kawaguchi K, Uehara T, Shishido T, Naito A, Cusack S
Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1.
1. Nat Commun - published June 2, 2018
2. Kooshapur H, Choudhury NR, Simon B, Mühlbauer M, Jussupow A, Fernandez N, Jones AN, Dallmann A, Gabel F, Camilloni C, Michlewski G, Caceres JF, Sattler M
An RNA-Binding Multimer Specifies Nematode Sperm Fate.
1. Cell Rep - published June 2, 2018
2. Aoki ST, Porter DF, Prasad A, Wickens M, Bingman CA, Kimble J
Ixodes scapularis does not harbor a stable midgut microbiome.
1. ISME J - published June 2, 2018
2. Ross BD, Hayes B, Radey MC, Lee X, Josek T, Bjork J, Neitzel D, Paskewitz S, Chou S, Mougous JD
Targeting TRAF6 E3 ligase activity with a small molecule inhibitor combats autoimmunity.
1. J Biol Chem - published June 2, 2018
2. Brenke JK, Popowicz GM, Schorpp K, Rothenaigner I, Roesner M, Meininger I, Kalinski C, Ringelstetter L, R'kyek O, Jürjens G, Vincendeau M, Plettenburg O, Sattler M, Krappmann D, Hadian K
Dissecting ribosomal particles throughout the kingdoms of life using advanced hybrid mass spectrometry methods.
1. Nat Commun - published June 2, 2018
2. van de Waterbeemd M, Tamara S, Fort KL, Damoc E, Franc V, Bieri P, Itten M, Makarov A, Ban N, Heck AJR
Structure of a human synaptic GABAA receptor.
1. Nature - published June 2, 2018
2. Zhu S, Noviello CM, Teng J, Walsh RM Jr, Kim JJ, Hibbs RE
Predicting the Enthalpy and Gibbs Energy of Sublimation by QSPR Modeling.
1. Sci Rep - published June 2, 2018
2. Meftahi N, Walker ML, Enciso M, Smith BJ
FamPlex: a resource for entity recognition and relationship resolution of human protein families and complexes in biomedical text mining.
1. BMC Bioinformatics - published June 2, 2018
2. Bachman JA, Gyori BM, Sorger PK
MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.
1. Mol Cell - published June 2, 2018
2. Hung PJ, Johnson B, Chen BR, Byrum AK, Bredemeyer AL, Yewdell WT, Johnson TE, Lee BJ, Deivasigamani S, Hindi I, Amatya P, Gross ML, Paull TT, Pisapia DJ, Chaudhuri J, Petrini JJH, Mosammaparast N, Amarasinghe GK, Zha S, Tyler JK, Sleckman BP
Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
1. Structure - published June 2, 2018
2. Jaiganesh A, De-la-Torre P, Patel AA, Termine DJ, Velez-Cortes F, Chen C, Sotomayor M
A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases.
1. Structure - published June 2, 2018
2. Gorelik M, Manczyk N, Pavlenco A, Kurinov I, Sidhu SS, Sicheri F
Snapshots of a molecular swivel in action.
1. Nucleic Acids Res - published June 1, 2018
2. Trejo CS, Rock RS, Stark WM, Boocock MR, Rice PA
The modules of trans-acyltransferase assembly lines redefined with a central acyl carrier protein.
1. Proteins - published June 1, 2018
2. Vander Wood DA, Keatinge-Clay AT
An origin of the immunogenicity of in vitro transcribed RNA.
1. Nucleic Acids Res - published June 1, 2018
2. Mu X, Greenwald E, Ahmad S, Hur S
A Pharmacogenetic Approach to the Treatment of Patients With PPARG Mutations.
1. Diabetes - published June 1, 2018
2. Agostini M, Schoenmakers E, Beig J, Fairall L, Szatmari I, Rajanayagam O, Muskett FW, Adams C, Marais AD, O'Rahilly S, Semple RK, Nagy L, Majithia AR, Schwabe JWR, Blom DJ, Murphy R, Chatterjee K, Savage DB
The life cycle of non-polio enteroviruses and how to target it.
1. Nat Rev Microbiol - published June 1, 2018
2. Baggen J, Thibaut HJ, Strating JRPM, van Kuppeveld FJM
The antibiotic cyclomarin blocks arginine-phosphate-induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis.
1. J Biol Chem - published June 1, 2018
2. Weinhäupl K, Brennich M, Kazmaier U, Lelievre J, Ballell L, Goldberg A, Schanda P, Fraga H
Structural Basis of Arrestin-Dependent Signal Transduction.
1. Trends Biochem Sci - published June 1, 2018
2. Chen Q, Iverson TM, Gurevich VV
The cytoplasmic dynein transport machinery and its many cargoes.
1. Nat Rev Mol Cell Biol - published June 1, 2018
2. Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74.
1. Angew Chem Int Ed Engl - published June 1, 2018
2. Pantouris G, Ho J, Shah D, Syed MA, Leng L, Bhandari V, Bucala R, Batista VS, Loria JP, Lolis EJ
Flagellum inheritance in Trypanosoma brucei requires a kinetoplastid-specific protein phosphatase.
1. J Biol Chem - published June 1, 2018
2. Zhou Q, Dong G, Li Z
Hydrogen Sulfide Sensing through Reactive Sulfur Species (RSS) and Nitroxyl (HNO) in Enterococcus faecalis.
1. ACS Chem Biol - published June 1, 2018
2. Shen J, Walsh BJC, Flores-Mireles AL, Peng H, Zhang Y, Zhang Y, Trinidad JC, Hultgren SJ, Giedroc DP
Publisher Correction: The life cycle of non-polio enteroviruses and how to target it.
1. Nat Rev Microbiol - published June 1, 2018
2. Baggen J, Thibaut HJ, Strating JRPM, van Kuppeveld FJM
Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2-MPER region.
1. Nat Microbiol - published June 1, 2018
2. Flyak AI, Kuzmina N, Murin CD, Bryan C, Davidson E, Gilchuk P, Gulka CP, Ilinykh PA, Shen X, Huang K, Ramanathan P, Turner H, Fusco ML, Lampley R, Kose N, King H, Sapparapu G, Doranz BJ, Ksiazek TG, Wright DW, Saphire EO, Ward AB, Bukreyev A, Crowe JE Jr
Heterocycles: Versatile control elements in bioactive macrocycles.
1. Bioorg Med Chem - published June 1, 2018
2. Soor HS, Appavoo SD, Yudin AK
Near-atomic model of microtubule-tau interactions.
1. Science - published June 1, 2018
2. Kellogg EH, Hejab NMA, Poepsel S, Downing KH, DiMaio F, Nogales E
Photochemistry for Well-Defined Polymers in Aqueous Media: From Fundamentals to Polymer Nanoparticles to Bioconjugates.
1. Macromol Rapid Commun - published June 1, 2018
2. Burridge KM, Wright TA, Page RC, Konkolewicz D
Does Hormone Therapy Use Increase Perioperative Complications in Abdominally Based Microsurgical Breast Reconstruction?
1. Plast Reconstr Surg - published June 1, 2018
2. Tran BNN, Ruan QZ, Cohen JB, Kamali P, Doval AF, Tobias AM, Singhal D, Lin SJ, Lee BT
Structural basis for MTR4-ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex.
1. Proc Natl Acad Sci U S A - published June 1, 2018
2. Puno MR, Lima CD
Coarse-grained simulations of actomyosin rings point to a nodeless model involving both unipolar and bipolar myosins.
1. Mol Biol Cell - published June 1, 2018
2. Nguyen LT, Swulius MT, Aich S, Mishra M, Jensen GJ
Gene therapy and genome surgery in the retina.
1. J Clin Invest - published June 1, 2018
2. DiCarlo JE, Mahajan VB, Tsang SH
Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity.
1. Mol Ther Nucleic Acids - published June 1, 2018
2. Shin B, Jung R, Oh H, Owens GE, Lee H, Kwak S, Lee R, Cotman SL, Lee JM, MacDonald ME, Song JJ, Vijayvargia R, Seong IS
Multi-Donor Longitudinal Antibody Repertoire Sequencing Reveals the Existence of Public Antibody Clonotypes in HIV-1 Infection.
1. Cell Host Microbe - published June 1, 2018
2. Setliff I, McDonnell WJ, Raju N, Bombardi RG, Murji AA, Scheepers C, Ziki R, Mynhardt C, Shepherd BE, Mamchak AA, Garrett N, Karim SA, Mallal SA, Crowe JE Jr, Morris L, Georgiev IS
cryoem-cloud-tools: A software platform to deploy and manage cryo-EM jobs in the cloud.
1. J Struct Biol - published June 1, 2018
2. Cianfrocco MA, Lahiri I, DiMaio F, Leschziner AE
Assessment of ab initio models of protein complexes by molecular dynamics.
1. PLoS Comput Biol - published June 1, 2018
2. Radom F, Plückthun A, Paci E
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
1. Nat Med - published June 1, 2018
2. Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD
Cryo-EM structure of the human neutral amino acid transporter ASCT2.
1. Nat Struct Mol Biol - published June 1, 2018
2. Garaeva AA, Oostergetel GT, Gati C, Guskov A, Paulino C, Slotboom DJ
Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state.
1. Nat Struct Mol Biol - published June 1, 2018
2. Lei HT, Ma J, Sanchez Martinez S, Gonen T
X-ray structural, functional and computational studies of the O2-sensitive E. coli hydrogenase-1 C19G variant reveal an unusual [4Fe-4S] cluster.
1. Chem Commun (Camb) - published June 1, 2018
2. Volbeda A, Mouesca JM, Darnault C, Roessler MM, Parkin A, Armstrong FA, Fontecilla-Camps JC
Plasticity in binding confers selectivity in ligand-induced protein degradation.
1. Nat Chem Biol - published June 1, 2018
2. Nowak RP, DeAngelo SL, Buckley D, He Z, Donovan KA, An J, Safaee N, Jedrychowski MP, Ponthier CM, Ishoey M, Zhang T, Mancias JD, Gray NS, Bradner JE, Fischer ES
Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits.
1. Genes Dev - published June 1, 2018
2. Youmans DT, Schmidt JC, Cech TR
The crystal structure of the Helicobacter pylori LlaJI.R1 N-terminal domain provides a model for site-specific DNA binding.
1. J Biol Chem - published June 1, 2018
2. Hosford CJ, Chappie JS
Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
1. Nature - published June 1, 2018
2. Chen MC, Tippana R, Demeshkina NA, Murat P, Balasubramanian S, Myong S, Ferré-D'Amaré AR
Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer.
1. Cell Host Microbe - published June 1, 2018
2. Zhang P, Gorman J, Geng H, Liu Q, Lin Y, Tsybovsky Y, Go EP, Dey B, Andine T, Kwon A, Patel M, Gururani D, Uddin F, Guzzo C, Cimbro R, Miao H, McKee K, Chuang GY, Martin L, Sironi F, Malnati MS, Desaire H, Berger EA, Mascola JR, Dolan MA, Kwong PD, Lusso P
Structural basis of mitochondrial receptor binding and constriction by DRP1.
1. Nature - published June 1, 2018
2. Kalia R, Wang RY, Yusuf A, Thomas PV, Agard DA, Shaw JM, Frost A
Conformational control and DNA-binding mechanism of the metazoan origin recognition complex.
1. Proc Natl Acad Sci U S A - published June 1, 2018
2. Bleichert F, Leitner A, Aebersold R, Botchan MR, Berger JM
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
1. Nature - published June 1, 2018
2. Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE
Structure of the µ-opioid receptor-Gi protein complex.
1. Nature - published June 1, 2018
2. Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK
Structural and functional analysis of mRNA export regulation by the nuclear pore complex.
1. Nat Commun - published June 1, 2018
2. Lin DH, Correia AR, Cai SW, Huber FM, Jette CA, Hoelz A
Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex.
1. Cell - published June 1, 2018
2. Weick EM, Puno MR, Januszyk K, Zinder JC, DiMattia MA, Lima CD
An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors.
1. Sci Rep - published June 1, 2018
2. Bratkowski M, Yang X, Liu X
A crystal structure of coil 1B of vimentin in the filamentous form provides a model of a high-order assembly of a vimentin filament.
1. FEBS J - published June 1, 2018
2. Pang AH, Obiero JM, Kulczyk AW, Sviripa VM, Tsodikov OV
New Insights into Ribosome Structure and Function.
1. Cold Spring Harb Perspect Biol - published June 1, 2018
2. Jobe A, Liu Z, Gutierrez-Vargas C, Frank J
Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxylase.
1. Angew Chem Int Ed Engl - published June 1, 2018
2. Harris NC, Born DA, Cai W, Huang Y, Martin J, Khalaf R, Drennan CL, Zhang W
RGG/RG Motif Regions in RNA Binding and Phase Separation.
1. J Mol Biol - published June 1, 2018
2. Chong PA, Vernon RM, Forman-Kay JD
A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System.
1. Cell - published June 1, 2018
2. Qin Y, Garrison BS, Ma W, Wang R, Jiang A, Li J, Mistry M, Bronson RT, Santoro D, Franco C, Robinton DA, Stevens B, Rossi DJ, Lu C, Springer TA
A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge.
1. Nat Commun - published June 1, 2018
2. Madani N, Princiotto AM, Mach L, Ding S, Prevost J, Richard J, Hora B, Sutherland L, Zhao CA, Conn BP, Bradley T, Moody MA, Melillo B, Finzi A, Haynes BF, Smith Iii AB, Santra S, Sodroski J
Sensitivity of peripheral membrane proteins to the membrane context: A case study of phosphatidylserine and the TIM proteins.
1. Biochim Biophys Acta - published June 1, 2018
2. Kerr D, Tietjen GT, Gong Z, Tajkhorshid E, Adams EJ, Lee KYC
Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure.
1. Elife - published June 1, 2018
2. Swinburne IA, Mosaliganti KR, Upadhyayula S, Liu TL, Hildebrand DGC, Tsai TY, Chen A, Al-Obeidi E, Fass AK, Malhotra S, Engert F, Lichtman JW, Kirchhausen T, Betzig E, Megason SG
Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.
1. Nat Commun - published June 1, 2018
2. Fanning SW, Hodges-Gallagher L, Myles DC, Sun R, Fowler CE, Plant IN, Green BD, Harmon CL, Greene GL, Kushner PJ
Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent.
1. Chem Commun (Camb) - published June 1, 2018
2. Yang M, Wu H, Chu J, Gabriel LA, Kim Y, Anderson KS, Furdui CM, Bierbach U
Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation.
1. Nature - published June 1, 2018
2. Yu R, Wang X, Moazed D
Activating HER3 mutations in breast cancer.
1. Oncotarget - published June 1, 2018
2. Mishra R, Alanazi S, Yuan L, Solomon T, Thaker TM, Jura N, Garrett JT