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115 Member Publications for February 2018

An Integrated Cell-Free Assay to Study Translation Regulation by Small Bacterial Noncoding RNAs.
1. Methods Mol Biol - published February 28, 2018
2. Michel E, Duss O, Allain FH
The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction.
1. Cell Discov - published February 27, 2018
2. Xu S, Liu Y, Li X, Liu Y, Meijers R, Zhang Y, Wang JH
Effects of long-term cadmium exposure on urinary metabolite profiles in mice.
1. J Toxicol Sci - published February 27, 2018
2. Sarma SN, Saleem A, Lee JY, Tokumoto M, Hwang GW, Man Chan H, Satoh M
Ryanodine Receptor Structure and Function in Health and Disease.
1. Subcell Biochem - published February 22, 2018
2. Santulli G, Lewis D, des Georges A, Marks AR, Frank J
Proteomic analysis of the human retina reveals region-specific susceptibilities to metabolic- and oxidative stress-related diseases.
1. PLoS One - published February 22, 2018
2. Velez G, Machlab DA, Tang PH, Sun Y, Tsang SH, Bassuk AG, Mahajan VB
Expression, Purification, and Biochemical Evaluation of Human RAD51 Protein.
1. Methods Enzymol - published February 21, 2018
2. Subramanyam S, Spies M
Preface.
1. Methods Enzymol - published February 21, 2018
2. Spies M, Malkova A
Observation and Analysis of RAD51 Nucleation Dynamics at Single-Monomer Resolution.
1. Methods Enzymol - published February 21, 2018
2. Subramanyam S, Kinz-Thompson CD, Gonzalez RL Jr, Spies M
Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation.
1. Immunity - published February 20, 2018
2. Goodwin E, Gilman MSA, Wrapp D, Chen M, Ngwuta JO, Moin SM, Bai P, Sivasubramanian A, Connor RI, Wright PF, Graham BS, McLellan JS, Walker LM
Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7.
1. ACS Infect Dis - published February 9, 2018
2. Bergstrom A, Katko A, Adkins Z, Hill J, Cheng Z, Burnett M, Yang H, Aitha M, Mehaffey MR, Brodbelt JS, Tehrani KHME, Martin NI, Bonomo RA, Page RC, Tierney DL, Fast W, Wright GD, Crowder MW
Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR).
1. J Biol Chem - published February 9, 2018
2. Seok SH, Ma ZX, Feltenberger JB, Chen H, Chen H, Scarlett C, Lin Z, Satyshur KA, Cortopassi M, Jefcoate CR, Ge Y, Tang W, Bradfield CA, Xing Y
Substrate Preferences Establish the Order of Cell Wall Assembly in Staphylococcus aureus.
1. J Am Chem Soc - published February 9, 2018
2. Schaefer K, Owens TW, Kahne D, Walker S
Pi-Pi contacts are an overlooked protein feature relevant to phase separation.
1. Elife - published February 9, 2018
2. Vernon RM, Chong PA, Tsang B, Kim TH, Bah A, Farber P, Lin H, Forman-Kay JD
Architecture of the human mTORC2 core complex.
1. Elife - published February 9, 2018
2. Stuttfeld E, Aylett CHS, Imseng S, Boehringer D, Scaiola A, Sauer E, Hall MN, Maier T, Ban N
Conformational states during vinculin unlocking differentially regulate focal adhesion properties.
1. Sci Rep - published February 9, 2018
2. Chorev DS, Volberg T, Livne A, Eisenstein M, Martins B, Kam Z, Jockusch BM, Medalia O, Sharon M, Geiger B
Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks.
1. Science - published February 9, 2018
2. Hughes MP, Sawaya MR, Boyer DR, Goldschmidt L, Rodriguez JA, Cascio D, Chong L, Gonen T, Eisenberg DS
Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation.
1. Cell - published February 8, 2018
2. Ahmad S, Mu X, Yang F, Greenwald E, Park JW, Jacob E, Zhang CZ, Hur S
Evolutionary conservation of the allosteric activation of factor VIIa by tissue factor in lamprey.
1. J Thromb Haemost - published February 8, 2018
2. Beeler DL, Aird WC, Grant MA
Conserved, unstructured regions in Pseudomonas aeruginosa PilO are important for type IVa pilus function.
1. Sci Rep - published February 8, 2018
2. Leighton TL, Mok MC, Junop MS, Howell PL, Burrows LL
Alternative Mode of E-Site tRNA Binding in the Presence of a Downstream mRNA Stem Loop at the Entrance Channel.
1. Structure - published February 8, 2018
2. Zhang Y, Hong S, Ruangprasert A, Skiniotis G, Dunham CM
Mutation of Phenylalanine-223 to Leucine Enhances Transformation of Benzo[a]pyrene by Ring-Hydroxylating Dioxygenase of Sphingobium sp. FB3 by increasing Accessibility of the Catalytic Site.
1. J Agric Food Chem - published February 7, 2018
2. Fu B, Xu T, Cui Z, Ng HL, Wang K, Li J, Li QX
Mavyret: A Pan-Genotypic Combination Therapy for the Treatment of Hepatitis C Infection_{Published as part of the Biochemistry series "Biochemistry to Bedside"}.
1. Biochemistry - published February 6, 2018
2. Matthew AN, Kurt Yilmaz N, Schiffer CA
Robo1 Forms a Compact Dimer-of-Dimers Assembly.
1. Structure - published February 6, 2018
2. Aleksandrova N, Gutsche I, Kandiah E, Avilov SV, Petoukhov MV, Seiradake E, McCarthy AA
Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent.
1. Structure - published February 6, 2018
2. Ely LK, Lolicato M, David T, Lowe K, Kim YC, Samuel D, Bessette P, Garcia JL, Mikita T, Minor DL Jr, Coughlin SR
Regulation of Kinase Activity in the Caenorhabditis elegans EGF Receptor, LET-23.
1. Structure - published February 6, 2018
2. Liu L, Thaker TM, Freed DM, Frazier N, Malhotra K, Lemmon MA, Jura N
Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding.
1. Nat Commun - published February 6, 2018
2. Guo HF, Tsai CL, Terajima M, Tan X, Banerjee P, Miller MD, Liu X, Yu J, Byemerwa J, Alvarado S, Kaoud TS, Dalby KN, Bota-Rabassedas N, Chen Y, Yamauchi M, Tainer JA, Phillips GN Jr., Kurie JM
Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp.
1. Nat Commun - published February 6, 2018
2. López-Sagaseta J, Beernink PT, Bianchi F, Santini L, Frigimelica E, Lucas AH, Pizza M, Bottomley MJ
Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly.
1. Cell Rep - published February 6, 2018
2. Protter DSW, Rao BS, Van Treeck B, Lin Y, Mizoue L, Rosen MK, Parker R
A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer.
1. J Cell Biol - published February 5, 2018
2. Colaluca IN, Basile A, Freiburger L, D'Uva V, Disalvatore D, Vecchi M, Confalonieri S, Tosoni D, Cecatiello V, Malabarba MG, Yang CJ, Kainosho M, Sattler M, Mapelli M, Pece S, Di Fiore PP
Structural insights into K48-linked ubiquitin chain formation by the Pex4p-Pex22p complex.
1. Biochem Biophys Res Commun - published February 5, 2018
2. Groves MR, Schroer CFE, Middleton AJ, Lunev S, Danda N, Ali AM, Marrink SJ, Williams C
15N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins.
1. Proc Natl Acad Sci U S A - published February 5, 2018
2. Chhabra S, Fischer P, Takeuchi K, Dubey A, Ziarek JJ, Boeszoermenyi A, Mathieu D, Bermel W, Davey NE, Wagner G, Arthanari H
An N-terminal Retention Module Anchors the Giant Adhesin LapA of Pseudomonas fluorescens at the Cell Surface: A Novel Sub-family of Type I Secretion Systems.
1. J Bacteriol - published February 5, 2018
2. Smith TJ, Font ME, Kelly CM, Sondermann H, O'Toole GA
Measuring Nucleosome Assembly Activity in vitro with the Nucleosome Assembly and Quantification (NAQ) Assay.
1. Bio Protoc - published February 5, 2018
2. Mattiroli F, Gu Y, Luger K
FRET-based Stoichiometry Measurements of Protein Complexes in vitro.
1. Bio Protoc - published February 5, 2018
2. Mattiroli F, Gu Y, Luger K
Bidirectional motility of kinesin-5 motor proteins: structural determinants, cumulative functions and physiological roles.
1. Cell Mol Life Sci - published February 3, 2018
2. Singh SK, Pandey H, Al-Bassam J, Gheber L
Positron Emission Tomography Assessment of the Intranasal Delivery Route for Orexin A.
1. ACS Chem Neurosci - published February 2, 2018
2. Van de Bittner GC, Van de Bittner KC, Wey HY, Rowe W, Dharanipragada R, Ying X, Hurst W, Giovanni A, Alving K, Gupta A, Hoekman J, Hooker JM
In Vivo [18F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates.
1. ACS Chem Neurosci - published February 2, 2018
2. Schoenberger M, Schroeder FA, Placzek MS, Carter RL, Rosen BR, Hooker JM, Sander CY
Prodomain-growth factor swapping in the structure of pro-TGF-β1.
1. J Biol Chem - published February 2, 2018
2. Zhao B, Xu S, Dong X, Lu C, Springer TA
Structural dissection of an interaction between transcription initiation and termination factors implicated in promoter-terminator cross-talk.
1. J Biol Chem - published February 2, 2018
2. Bratkowski M, Unarta IC, Zhu L, Shubbar M, Huang X, Liu X
Structural Basis of Enhanced Crystallizability Induced by a Molecular Chaperone for Antibody Antigen-Binding Fragments.
1. J Mol Biol - published February 2, 2018
2. Ereño-Orbea J, Sicard T, Cui H, Carson J, Hermans P, Julien JP
Predictive Power of Different Types of Experimental Restraints in Small Molecule Docking: A Review.
1. J Chem Inf Model - published February 2, 2018
2. Fu DY, Meiler J
Mapping two neurosteroid-modulatory sites in the prototypic pentameric ligand-gated ion channel GLIC.
1. J Biol Chem - published February 2, 2018
2. Cheng WWL, Chen ZW, Bracamontes JR, Budelier MM, Krishnan K, Shin DJ, Wang C, Jiang X, Covey DF, Akk G, Evers AS
The Nature and Reactivity of Ferryl Heme in Compounds I and II.
1. Acc Chem Res - published February 2, 2018
2. Moody PCE, Raven EL
Structures of human PRC2 with its cofactors AEBP2 and JARID2.
1. Science - published February 2, 2018
2. Kasinath V, Faini M, Poepsel S, Reif D, Feng XA, Stjepanovic G, Aebersold R, Nogales E
Inhibiting β-Catenin by β-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy.
1. Front Pharmacol - published February 2, 2018
2. Qin JJ, Wang W, Li X, Deokar H, Buolamwini JK, Zhang R
UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins.
1. Nat Commun - published February 2, 2018
2. Hellerschmied D, Roessler M, Lehner A, Gazda L, Stejskal K, Imre R, Mechtler K, Dammermann A, Clausen T
Cryo-tomography Tilt-series Alignment with Consideration of the Beam-induced Sample Motion.
1. J Struct Biol - published February 2, 2018
2. Fernandez JJ, Li S, Bharat TAM, Agard DA
A Calmodulin C-Lobe Ca²⁺-Dependent Switch Governs Kv7 Channel Function.
1. Neuron - published February 2, 2018
2. Chang A, Abderemane-Ali F, Hura GL, Rossen ND, Gate RE, Minor DL Jr
3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound.
1. Elife - published February 2, 2018
2. Brignole EJ, Tsai KL, Chittuluru J, Li H, Aye Y, Penczek PA, Stubbe J, Drennan CL, Asturias F
Gi- and Gs-coupled GPCRs show different modes of G-protein binding.
1. Proc Natl Acad Sci U S A - published February 2, 2018
2. Van Eps N, Altenbach C, Caro LN, Latorraca NR, Hollingsworth SA, Dror RO, Ernst OP, Hubbell WL
Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3.
1. Cell Rep - published February 2, 2018
2. Gonzalez Herrera KN, Zaganjor E, Ishikawa Y, Spinelli JB, Yoon H, Lin JR, Satterstrom FK, Ringel A, Mulei S, Souza A, Gorham JM, Benson CC, Seidman JG, Sorger PK, Clish CB, Haigis MC
Structure of full-length human TRPM4.
1. Proc Natl Acad Sci U S A - published February 2, 2018
2. Duan J, Li Z, Li J, Santa-Cruz A, Sanchez-Martinez S, Zhang J, Clapham DE
MreB filaments align along greatest principal membrane curvature to orient cell wall synthesis.
1. Elife - published February 2, 2018
2. Hussain S, Wivagg CN, Szwedziak P, Wong F, Schaefer K, Izoré T, Renner LD, Holmes MJ, Sun Y, Bisson-Filho AW, Walker S, Amir A, Löwe J, Garner EC
A novel de novo CAPN5 mutation in a patient with inflammatory vitreoretinopathy, hearing loss, and developmental delay.
1. Cold Spring Harb Mol Case Stud - published February 2, 2018
2. Velez G, Bassuk AG, Schaefer KA, Brooks B, Gakhar L, Mahajan M, Kahn P, Tsang SH, Ferguson PJ, Mahajan VB
Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly.
1. Cell - published February 2, 2018
2. Su Z, Wu C, Shi L, Luthra P, Pintilie GD, Johnson B, Porter JR, Ge P, Chen M, Liu G, Frederick TE, Binning JM, Bowman GR, Zhou ZH, Basler CF, Gross ML, Leung DW, Chiu W, Amarasinghe GK
Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer.
1. J Clin Invest - published February 2, 2018
2. Zhao N, Cao J, Xu L, Tang Q, Dobrolecki LE, Lv X, Talukdar M, Lu Y, Wang X, Hu DZ, Shi Q, Xiang Y, Wang Y, Liu X, Bu W, Jiang Y, Li M, Gong Y, Sun Z, Ying H, Yuan B, Lin X, Feng XH, Hartig SM, Li F, Shen H, Chen Y, Han L, Zeng Q, Patterson JB, Kaipparettu BA, Putluri N, Sicheri F, Rosen JM, Lewis MT, Chen X
Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts.
1. Elife - published February 2, 2018
2. Boyaci H, Chen J, Lilic M, Palka M, Mooney RA, Landick R, Darst SA, Campbell EA
Recurrent Wheezing in Children Following Human Metapneumovirus Infection.
1. J Allergy Clin Immunol - published February 2, 2018
2. Coverstone AM, Wilson BS, Burgdorf D, Schechtman KB, Storch GA, Holtzman MJ, Castro M, Bacharier LB, Sumino K
A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state.
1. Nat Commun - published February 2, 2018
2. Fahrner M, Stadlbauer M, Muik M, Rathner P, Stathopulos P, Ikura M, Müller N, Romanin C
Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms.
1. Nat Struct Mol Biol - published February 2, 2018
2. Deng Z, Paknejad N, Maksaev G, Sala-Rabanal M, Nichols CG, Hite RK, Yuan P
Atomic Force Microscopy for Molecular Structure Elucidation.
1. Angew Chem Int Ed Engl - published February 2, 2018
2. Gross L, Schuler B, Pavliček N, Fatayer S, Majzik Z, Moll N, Peña D, Meyer G
Puf3 participates in ribosomal biogenesis in malaria parasites.
1. J Cell Sci - published February 2, 2018
2. Liang X, Hart KJ, Dong G, Siddiqui FA, Sebastian A, Li X, Albert I, Miao J, Lindner SE, Cui L
Mouse and Human Monoclonal Antibodies Protect against Infection by Multiple Genotypes of Japanese Encephalitis Virus.
1. MBio - published February 2, 2018
2. Fernandez E, Kose N, Edeling MA, Adhikari J, Sapparapu G, Lazarte SM, Nelson CA, Govero J, Gross ML, Fremont DH, Crowe JE Jr., Diamond MS
NAD⁺ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains.
1. Nat Commun - published February 2, 2018
2. Langelier MF, Zandarashvili L, Aguiar PM, Black BE, Pascal JM
Pulling the BAX trigger for tumor cell death.
1. Oncotarget - published February 2, 2018
2. Reyna DE, Gavathiotis E
Meningococcal Vaccines: Current Status and Emerging Strategies.
1. Vaccines (Basel) - published February 2, 2018
2. McCarthy PC, Sharyan A, Sheikhi Moghaddam L
Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC.
1. Neuron - published February 2, 2018
2. Liu Y, Bhowmick T, Liu Y, Gao X, Mertens HDT, Svergun DI, Xiao J, Zhang Y, Wang JH, Meijers R
Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple).
1. ACS Cent Sci - published February 2, 2018
2. Batiste L, Unzue A, Dolbois A, Hassler F, Wang X, Deerain N, Zhu J, Spiliotopoulos D, Nevado C, Caflisch A
The Unusual Transmembrane Partition of the Hexameric Channel of the Hepatitis C Virus.
1. Structure - published February 2, 2018
2. Chen W, Dev J, Mezhyrova J, Pan L, Piai A, Chou JJ
Using experimental evolution to identify druggable targets that could inhibit the evolution of antimicrobial resistance.
1. J Antibiot (Tokyo) - published February 1, 2018
2. Mehta HH, Prater AG, Shamoo Y
MightyScreen: An Open-Source Visualization Application for Screening Data Analysis.
1. SLAS Discov - published February 1, 2018
2. Wang L, Yang Q, Jaimes A, Wang T, Strobelt H, Chen J, Sliz P
Finding the needle in the haystack: towards solving the protein-folding problem computationally.
1. Crit Rev Biochem Mol Biol - published February 1, 2018
2. Li B, Fooksa M, Heinze S, Meiler J
PURA syndrome: clinical delineation and genotype-phenotype study in 32 individuals with review of published literature.
1. J Med Genet - published February 1, 2018
2. Reijnders MRF, Janowski R, Alvi M, Self JE, van Essen TJ, Vreeburg M, Rouhl RPW, Stevens SJC, Stegmann APA, Schieving J, Pfundt R, van Dijk K, Smeets E, Stumpel CTRM, Bok LA, Cobben JM, Engelen M, Mansour S, Whiteford M, Chandler KE, Douzgou S, Cooper NS, Tan EC, Foo R, Lai AHM, Rankin J, Green A, Lönnqvist T, Isohanni P, Williams S, Ruhoy I, Carvalho KS, Dowling JJ, Lev DL, Sterbova K, Lassuthova P, Neupauerová J, Waugh JL, Keros S, Clayton-Smith J, Smithson SF, Brunner HG, van Hoeckel C, Anderson M, Clowes VE, Siu VM, Ddd Study T, Selber P, Leventer RJ, Nellaker C, Niessing D, Hunt D, Baralle D
Application of a Schizosaccharomyces pombe Edc1-fused Dcp1-Dcp2 decapping enzyme for transcription start site mapping.
1. RNA - published February 1, 2018
2. Paquette DR, Mugridge JS, Weinberg DE, Gross JD
An ultraprocessive, accurate reverse transcriptase encoded by a metazoan group II intron.
1. RNA - published February 1, 2018
2. Zhao C, Liu F, Pyle AM
Interplay between the catabolite repression control protein Crc, Hfq and RNA in Hfq-dependent translational regulation in Pseudomonas aeruginosa.
1. Nucleic Acids Res - published February 1, 2018
2. Sonnleitner E, Wulf A, Campagne S, Pei XY, Wolfinger MT, Forlani G, Prindl K, Abdou L, Resch A, Allain FH, Luisi BF, Urlaub H, Bläsi U
Personalized Proteomics in Proliferative Vitreoretinopathy Implicate Hematopoietic Cell Recruitment and mTOR as a Therapeutic Target.
1. Am J Ophthalmol - published February 1, 2018
2. Roybal CN, Velez G, Toral MA, Tsang SH, Bassuk AG, Mahajan VB
Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies.
1. Chem Rev - published February 1, 2018
2. Jiang H, Zhang X, Chen X, Aramsangtienchai P, Tong Z, Lin H
Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus.
1. Nat Microbiol - published February 1, 2018
2. Chen J, Sathiyamoorthy K, Zhang X, Schaller S, Perez White BE, Jardetzky TS, Longnecker R
High-throughput in situ X-ray screening of and data collection from protein crystals at room temperature and under cryogenic conditions.
1. Nat Protoc - published February 1, 2018
2. Broecker J, Morizumi T, Ou WL, Klingel V, Kuo A, Kissick DJ, Ishchenko A, Lee MY, Xu S, Makarov O, Cherezov V, Ogata CM, Ernst OP
Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant.
1. Biochemistry - published February 1, 2018
2. O'Donnell JP, Marsh HM, Sondermann H, Sevier CS
PD-L1 on host cells is essential for PD-L1 blockade-mediated tumor regression.
1. J Clin Invest - published February 1, 2018
2. Tang H, Liang Y, Anders RA, Taube JM, Qiu X, Mulgaonkar A, Liu X, Harrington SM, Guo J, Xin Y, Xiong Y, Nham K, Silvers W, Hao G, Sun X, Chen M, Hannan R, Qiao J, Dong H, Peng H, Fu YX
Structure of the fission yeast actomyosin ring during constriction.
1. Proc Natl Acad Sci U S A - published February 1, 2018
2. Swulius MT, Nguyen LT, Ladinsky MS, Ortega DR, Aich S, Mishra M, Jensen GJ
Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.
1. Nat Struct Mol Biol - published February 1, 2018
2. Clerici M, Faini M, Muckenfuss LM, Aebersold R, Jinek M
Structure-based inhibitors of tau aggregation.
1. Nat Chem - published February 1, 2018
2. Seidler PM, Boyer DR, Rodriguez JA, Sawaya MR, Cascio D, Murray K, Gonen T, Eisenberg DS
Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes.
1. Nat Struct Mol Biol - published February 1, 2018
2. Poepsel S, Kasinath V, Nogales E
Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.
1. Chem Rev - published February 1, 2018
2. Ali I, Conrad RJ, Verdin E, Ott M
MEK drives BRAF activation through allosteric control of KSR proteins.
1. Nature - published February 1, 2018
2. Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien M
Hoisted by their own petard: do microbial enzymes hold the solution to treating and preventing biofilm infections?
1. Future Microbiol - published February 1, 2018
2. Snarr BD, Howell PL, Sheppard DC
High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
1. Anal Biochem - published February 1, 2018
2. Burns MC, Howes JE, Sun Q, Little AJ, Camper DV, Abbott JR, Phan J, Lee T, Waterson AG, Rossanese OW, Fesik SW
Structure of prothrombin in the closed form reveals new details on the mechanism of activation.
1. Sci Rep - published February 1, 2018
2. Chinnaraj M, Chen Z, Pelc LA, Grese Z, Bystranowska D, Di Cera E, Pozzi N
Measuring Integrin Conformational Change on the Cell Surface with Super-Resolution Microscopy.
1. Cell Rep - published February 1, 2018
2. Moore TI, Aaron J, Chew TL, Springer TA
Cross-priming induces immunodomination in the presence of viral MHC class I inhibition.
1. PLoS Pathog - published February 1, 2018
2. Lauron EJ, Yang L, Elliott JI, Gainey MD, Fremont DH, Yokoyama WM
Small molecule-mediated activation of RAS elicits biphasic modulation of phospho ERK levels that are regulated through negative feedback on SOS1.
1. Mol Cancer Ther - published February 1, 2018
2. Howes JE, Akan DT, Burns MC, Rossanese OW, Waterson AG, Fesik SW
Introduction: Posttranslational Protein Modification.
1. Chem Rev - published February 1, 2018
2. Lin H, Caroll KS
Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody.
1. Cell Rep - published February 1, 2018
2. Kwon YD, Chuang GY, Zhang B, Bailer RT, Doria-Rose NA, Gindin TS, Lin B, Louder MK, McKee K, O'Dell S, Pegu A, Schmidt SD, Asokan M, Chen X, Choe M, Georgiev IS, Jin V, Pancera M, Rawi R, Wang K, Chaudhuri R, Kueltzo LA, Manceva SD, Todd JP, Scorpio DG, Kim M, Reinherz EL, Wagh K, Korber BM, Connors M, Shapiro L, Mascola JR, Kwong PD
Lipopolysaccharide is transported to the cell surface by a membrane-to-membrane protein bridge.
1. Science - published February 1, 2018
2. Sherman DJ, Xie R, Taylor RJ, George AH, Okuda S, Foster PJ, Needleman DJ, Kahne D
[A new hope to fight invasive fungal infection].
1. Med Sci (Paris) - published February 1, 2018
2. Petosa C, Govin J, Mietton F
Integrating linear optimization with structural modeling to increase HIV neutralization breadth.
1. PLoS Comput Biol - published February 1, 2018
2. Sevy AM, Panda S, Crowe JE Jr, Meiler J, Vorobeychik Y
Structural basis of siRNA recognition by TRBP double-stranded RNA binding domains.
1. EMBO J - published February 1, 2018
2. Masliah G, Maris C, König SL, Yulikov M, Aeschimann F, Malinowska AL, Mabille J, Weiler J, Holla A, Hunziker J, Meisner-Kober N, Schuler B, Jeschke G, Allain FH
Novosphingobium aromaticivorans uses a Nu-class glutathione-S-transferase as a glutathione lyase in breaking the β-aryl ether bond of lignin.
1. J Biol Chem - published February 1, 2018
2. Kontur WS, Bingman CA, Olmsted CN, Wassarman DR, Ulbrich A, Gall DL, Smith RW, Yusko LM, Fox BG, Noguera DR, Coon JJ, Donohue TJ
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity.
1. Science - published February 1, 2018
2. Chen JS, Ma E, Harrington LB, Da Costa M, Tian X, Palefsky JM, Doudna JA
Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6.
1. Science - published February 1, 2018
2. Gootenberg JS, Abudayyeh OO, Kellner MJ, Joung J, Collins JJ, Zhang F
Physical basis of amyloid fibril polymorphism.
1. Nat Commun - published February 1, 2018
2. Close W, Neumann M, Schmidt A, Hora M, Annamalai K, Schmidt M, Reif B, Schmidt V, Grigorieff N, Fändrich M
Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor.
1. J Cell Biol - published February 1, 2018
2. Gutmann T, Kim KH, Grzybek M, Walz T, Coskun Ü
Bringing diffuse X-ray scattering into focus.
1. Curr Opin Struct Biol - published February 1, 2018
2. Wall ME, Wolff AM, Fraser JS
New Zealand glowworm (Arachnocampa luminosa) bioluminescence is produced by a firefly-like luciferase but an entirely new luciferin.
1. Sci Rep - published February 1, 2018
2. Watkins OC, Sharpe ML, Perry NB, Krause KL
Structure of a eukaryotic cytoplasmic pre-40S ribosomal subunit.
1. EMBO J - published February 1, 2018
2. Scaiola A, Peña C, Weisser M, Böhringer D, Leibundgut M, Klingauf-Nerurkar P, Gerhardy S, Panse VG, Ban N
Photoelectrochemical modulation of neuronal activity with free-standing coaxial silicon nanowires.
1. Nat Nanotechnol - published February 1, 2018
2. Parameswaran R, Carvalho-de-Souza JL, Jiang Y, Burke MJ, Zimmerman JF, Koehler K, Phillips AW, Yi J, Adams EJ, Bezanilla F, Tian B
Butyrophilins and γδ T Cell Recognition.
1. Semin Cell Dev Biol - published February 1, 2018
2. Gu S, Borowska M, Boughter CT, Adams EJ
Human antibody recognition of antigenic site IV on Pneumovirus fusion proteins.
1. PLoS Pathog - published February 1, 2018
2. Mousa JJ, Binshtein E, Human S, Fong RH, Alvarado G, Doranz BJ, Moore ML, Ohi MD, Crowe JE Jr
Editorial overview: Folding and binding: In silico, in vitro and in cellula.
1. Curr Opin Struct Biol - published February 1, 2018
2. Caflisch A, Gianni S
A minimal RNA ligand for potent RIG-I activation in living mice.
1. Sci Adv - published February 1, 2018
2. Linehan MM, Dickey TH, Molinari ES, Fitzgerald ME, Potapova O, Iwasaki A, Pyle AM
Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR-mediated direct in vivo screening.
1. Sci Adv - published February 1, 2018
2. Wang G, Chow RD, Ye L, Guzman CD, Dai X, Dong MB, Zhang F, Sharp PA, Platt RJ, Chen S
DIALS: implementation and evaluation of a new integration package.
1. Acta Crystallogr D Struct Biol - published February 1, 2018
2. Winter G, Waterman DG, Parkhurst JM, Brewster AS, Gildea RJ, Gerstel M, Fuentes-Montero L, Vollmar M, Michels-Clark T, Young ID, Sauter NK, Evans G