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122 Member Publications for January 2018

Biochemical and structural characterization of a novel cooperative binding mode by Pit-1 with CATT repeats in the macrophage migration inhibitory factor promoter.
1. Nucleic Acids Res - published January 25, 2018
2. Agarwal S, Cho TY
The Modern Research Data Portal: a design pattern for networked, data-intensive science.
1. PeerJ Comput Sci - published January 15, 2018
2. Chard K, Dart E, Foster I, Shifflett D, Tuecke S, Williams J
The centrosomin CM2 domain is a multi-functional binding domain with distinct cell cycle roles.
1. PLoS One - published January 10, 2018
2. Citron YR, Fagerstrom CJ, Keszthelyi B, Huang B, Rusan NM, Kelly MJS, Agard DA
A Survey of the Use of Iterative Reconstruction Algorithms in Electron Microscopy.
1. Biomed Res Int - published January 10, 2018
2. Sorzano COS, Vargas J, Otón J, de la Rosa-Trevín JM, Vilas JL, Kazemi M, Melero R, Del Caño L, Cuenca J, Conesa P, Gómez-Blanco J, Marabini R, Carazo JM
Structure of mycobacterial 3'-to-5' RNA:DNA helicase Lhr bound to a ssDNA tracking strand highlights distinctive features of a novel family of bacterial helicases.
1. Nucleic Acids Res - published January 9, 2018
2. Ejaz A, Ordonez H, Jacewicz A, Ferrao R, Shuman S
Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus.
1. Proc Natl Acad Sci U S A - published January 9, 2018
2. Baggen J, Hurdiss DL, Zocher G, Mistry N, Roberts RW, Slager JJ, Guo H, van Vliet ALW, Wahedi M, Benschop K, Duizer E, de Haan CAM, de Vries E, Casasnovas JM, de Groot RJ, Arnberg N, Stehle T, Ranson NA, Thibaut HJ, van Kuppeveld FJM
Reconstitution of Staphylococcus aureus Lipoteichoic Acid Synthase Activity Identifies Congo Red as a Selective Inhibitor.
1. J Am Chem Soc - published January 9, 2018
2. Vickery CR, Wood BM, Morris HG, Losick R, Walker S
Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism.
1. J Biol Chem - published January 9, 2018
2. Huang Q, Stalnecker C, Zhang C, McDermott LA, Iyer P, O'Neill J, Reimer S, Cerione RA, Katt WP
Publisher Correction: The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.
1. Nat Commun - published January 8, 2018
2. Herschhorn A, Gu C, Moraca F, Ma X, Farrell M, Smith AB 3rd, Pancera M, Kwong PD, Schön A, Freire E, Abrams C, Blanchard SC, Mothes W, Sodroski JG
Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.
1. J Biol Chem - published January 5, 2018
2. Matho MH, Schlossman A, Gilchuk IM, Miller G, Mikulski Z, Hupfer M, Wang J, Bitra A, Meng X, Xiang Y, Kaever T, Doukov T, Ley K, Crotty S, Peters B, Hsieh-Wilson LC, Crowe JE Jr, Zajonc DM
RNA-dependent RNA targeting by CRISPR-Cas9.
1. Elife - published January 5, 2018
2. Strutt SC, Torrez RM, Kaya E, Negrete OA, Doudna JA
Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax.
1. Science - published January 5, 2018
2. Gruszczyk J, Kanjee U, Chan LJ, Menant S, Malleret B, Lim NTY, Schmidt CQ, Mok YF, Lin KM, Pearson RD, Rangel G, Smith BJ, Call MJ, Weekes MP, Griffin MDW, Murphy JM, Abraham J, Sriprawat K, Menezes MJ, Ferreira MU, Russell B, Renia L, Duraisingh MT, Tham WH
Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors.
1. PLoS Pathog - published January 5, 2018
2. Binning JM, Smith AM, Hultquist JF, Craik CS, Caretta N, Campbell MG, Burton L, La Greca F, McGregor MJ, Ta HM, Bartholomeeusen K, Peterlin BM, Krogan NJ, Sevillano N, Cheng Y, Gross JD
In vitro Reconstitution, Functional Dissection, and Mutational Analysis of Metal Ion Transport by Mitoferrin-1.
1. J Biol Chem - published January 5, 2018
2. Christenson ET, Gallegos AS, Banerjee A
Evaluation of a method to measure HHV-6B infection in vitro based on cell size.
1. Virol J - published January 5, 2018
2. Becerra-Artiles A, Santoro T, Stern LJ
PDBe: towards reusable data delivery infrastructure at protein data bank in Europe.
1. Nucleic Acids Res - published January 4, 2018
2. Mir S, Alhroub Y, Anyango S, Armstrong DR, Berrisford JM, Clark AR, Conroy MJ, Dana JM, Deshpande M, Gupta D, Gutmanas A, Haslam P, Mak L, Mukhopadhyay A, Nadzirin N, Paysan-Lafosse T, Sehnal D, Sen S, Smart OS, Varadi M, Kleywegt GJ, Velankar S
Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions.
1. Mol Cell - published January 4, 2018
2. Kim J, Sturgill D, Sebastian R, Khurana S, Tran AD, Edwards GB, Kruswick A, Burkett S, Hosogane EK, Hannon WW, Weyemi U, Bonner WM, Luger K, Oberdoerffer P
Visualizing the Nucleotide Addition Cycle of Viral RNA-Dependent RNA Polymerase.
1. Viruses - published January 4, 2018
2. Wu J, Gong P
Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.
1. Nat Commun - published January 4, 2018
2. Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA
Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope.
1. J Autoimmun - published January 4, 2018
2. Evangelista F, Roth AJ, Prisayanh P, Temple BR, Li N, Qian Y, Culton DA, Liu Z, Harrison OJ, Brasch J, Honig B, Shapiro L, Diaz LA
Small angle X-ray scattering and cross-linking for data assisted protein structure prediction in CASP 12 with prospects for improved accuracy.
1. Proteins - published January 4, 2018
2. Ogorzalek TL, Hura GL, Belsom A, Burnett KH, Kryshtafovych A, Tainer JA, Rappsilber J, Tsutakawa SE, Fidelis K
KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS.
1. Cell - published January 4, 2018
2. Ambrogio C, Köhler J, Zhou ZW, Wang H, Paranal R, Li J, Capelletti M, Caffarra C, Li S, Lv Q, Gondi S, Hunter JC, Lu J, Chiarle R, Santamaría D, Westover KD, Jänne PA
Systems Approaches to Understanding and Designing Allosteric Proteins.
1. Biochemistry - published January 3, 2018
2. Raman S
De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles.
1. J Am Chem Soc - published January 3, 2018
2. Zhang SQ, Chino M, Liu L, Tang Y, Hu X, DeGrado WF, Lombardi A
Structure of the glucagon receptor in complex with a glucagon analogue.
1. Nature - published January 3, 2018
2. Zhang H, Qiao A, Yang L, Van Eps N, Frederiksen KS, Yang D, Dai A, Cai X, Zhang H, Yi C, Cao C, He L, Yang H, Lau J, Ernst OP, Hanson MA, Stevens RC, Wang MW, Reedtz-Runge S, Jiang H, Zhao Q, Wu B
Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches.
1. Nat Commun - published January 3, 2018
2. Liu X, Cheng J, Zhang G, Ding W, Duan L, Yang J, Kui L, Cheng X, Ruan J, Fan W, Chen J, Long G, Zhao Y, Cai J, Wang W, Ma Y, Dong Y, Yang S, Jiang H
Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication.
1. Nat Commun - published January 3, 2018
2. Williams GD, Townsend D, Wylie KM, Kim PJ, Amarasinghe GK, Kutluay SB, Boon ACM
Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control.
1. Nat Commun - published January 3, 2018
2. Schmid M, Ernst P, Honegger A, Suomalainen M, Zimmermann M, Braun L, Stauffer S, Thom C, Dreier B, Eibauer M, Kipar A, Vogel V, Greber UF, Medalia O, Plückthun A
Effects of rigidity on the selectivity of protein kinase inhibitors.
1. Eur J Med Chem - published January 3, 2018
2. Assadieskandar A, Yu C, Maisonneuve P, Liu X, Chen YC, Prakash GKS, Kurinov I, Sicheri F, Zhang C
Integrative structural investigation on the architecture of human Importin4_histone H3/H4_Asf1a complex and its histone H3 tail binding.
1. J Mol Biol - published January 3, 2018
2. Yoon J, Kim SJ, An S, Cho S, Leitner A, Jung T, Aebersold R, Hebert H, Cho US, Song JJ
Generation of novel induced pluripotent stem cell (iPSC) line from a 16-year-old sialidosis patient with NEU-1 gene mutation.
1. Stem Cell Res - published January 3, 2018
2. Liu SP, Hsu YH, Huang CY, Ho MC, Cheng YC, Wen CH, Lu HE, Tsai CH, Shyu WC, Hsieh PCH
Generation of 2 induced pluripotent stem cell lines derived from patients with Parkinson's disease carrying LRRK2 G2385R variant.
1. Stem Cell Res - published January 3, 2018
2. Cheng YC, Huang CY, Ho MC, Hsu YH, Syu SH, Lu HE, Lin HI, Lin CH, Hsieh PCH
Intramembrane Thiol Oxidoreductases: Evolutionary Convergence and Structural Controversy.
1. Biochemistry - published January 2, 2018
2. Li S, Shen G, Li W
Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X.
1. Nucleic Acids Res - published January 2, 2018
2. Weldon C, Dacanay JG, Gokhale V, Boddupally PVL, Behm-Ansmant I, Burley GA, Branlant C, Hurley LH, Dominguez C, Eperon IC
Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection.
1. J Exp Med - published January 2, 2018
2. Scally SW, Murugan R, Bosch A, Triller G, Costa G, Mordmüller B, Kremsner PG, Sim BKL, Hoffman SL, Levashina EA, Wardemann H, Julien JP
Metabolic reprogramming of human CD8⁺ memory T cells through loss of SIRT1.
1. J Exp Med - published January 2, 2018
2. Jeng MY, Hull PA, Fei M, Kwon HS, Tsou CL, Kasler H, Ng CP, Gordon DE, Johnson J, Krogan N, Verdin E, Ott M
Membrane Protein Structure in Live Cells: Methodology for Studying Drug Interaction by Mass Spectrometry-Based Footprinting.
1. Biochemistry - published January 2, 2018
2. Shen G, Li S, Cui W, Liu S, Yang Y, Gross M, Li W
PnuT uses a facilitated diffusion mechanism for thiamine uptake.
1. J Gen Physiol - published January 2, 2018
2. Jaehme M, Singh R, Garaeva AA, Duurkens RH, Slotboom DJ
Second-Shell Basic Residues Expand the Two-Metal-Ion Architecture of DNA and RNA Processing Enzymes.
1. Structure - published January 2, 2018
2. Genna V, Colombo M, De Vivo M, Marcia M
Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.
1. Structure - published January 2, 2018
2. Suno R, Kimura KT, Nakane T, Yamashita K, Wang J, Fujiwara T, Yamanaka Y, Im D, Horita S, Tsujimoto H, Tawaramoto MS, Hirokawa T, Nango E, Tono K, Kameshima T, Hatsui T, Joti Y, Yabashi M, Shimamoto K, Yamamoto M, Rosenbaum DM, Iwata S, Shimamura T, Kobayashi T
Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR-Cas effector complexes.
1. Nucleic Acids Res - published January 2, 2018
2. Vlot M, Houkes J, Lochs SJA, Swarts DC, Zheng P, Kunne T, Mohanraju P, Anders C, Jinek M, van der Oost J, Dickman MJ, Brouns SJJ
Synergistic anti-HCV broadly neutralizing human monoclonal antibodies with independent mechanisms.
1. Proc Natl Acad Sci U S A - published January 2, 2018
2. Mankowski MC, Kinchen VJ, Wasilewski LN, Flyak AI, Ray SC, Crowe JE Jr, Bailey JR
Deciphering the Dynamic Interaction Profile of an Intrinsically Disordered Protein by NMR Exchange Spectroscopy.
1. J Am Chem Soc - published January 2, 2018
2. Delaforge E, Kragelj J, Tengo L, Palencia A, Milles S, Bouvignies G, Salvi N, Blackledge M, Jensen MR
Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors.
1. Structure - published January 2, 2018
2. Malaby AW, Das S, Chakravarthy S, Irving TC, Bilsel O, Lambright DG
CDC42 binds PAK4 via an extended GTPase-effector interface.
1. Proc Natl Acad Sci U S A - published January 2, 2018
2. Ha BH, Boggon TJ
Coiled-Coil Formation Conveys a STIM1 Signal from ER Lumen to Cytoplasm.
1. Cell Rep - published January 2, 2018
2. Hirve N, Rajanikanth V, Hogan PG, Gudlur A
Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease.
1. Proc Natl Acad Sci U S A - published January 2, 2018
2. Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, Giles K, DeGrado WF, Prusiner SB
Structure of the C1r-C1s interaction of the C1 complex of complement activation.
1. Proc Natl Acad Sci U S A - published January 2, 2018
2. Almitairi JOM, Venkatraman Girija U, Furze CM, Simpson-Gray X, Badakshi F, Marshall JE, Schwaeble WJ, Mitchell DA, Moody PCE, Wallis R
The Structural Asymmetry of Mitochondrial Hsp90 (Trap1) Determines Fine Tuning of Functional Dynamics.
1. J Chem Theory Comput - published January 2, 2018
2. Moroni E, Agard DA, Colombo G
Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT.
1. Nature - published January 2, 2018
2. Diver MM, Pedi L, Koide A, Koide S, Long SB
Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
1. Nature - published January 2, 2018
2. Lee S, Choi J, Mohanty J, Sousa LP, Tome F, Pardon E, Steyaert J, Lemmon MA, Lax I, Schlessinger J
Regulation of embryonic haematopoietic multipotency by EZH1.
1. Nature - published January 2, 2018
2. Vo LT, Kinney MA, Liu X, Zhang Y, Barragan J, Sousa PM, Jha DK, Han A, Cesana M, Shao Z, North TE, Orkin SH, Doulatov S, Xu J, Daley GQ
Analytical Approaches to Improve Accuracy in Solving the Protein Topology Problem.
1. Molecules - published January 2, 2018
2. Al Nasr K, Yousef F, Jebril R, Jones C
Centipedes subdue giant prey by blocking KCNQ channels.
1. Proc Natl Acad Sci U S A - published January 2, 2018
2. Luo L, Li B, Wang S, Wu F, Wang X, Liang P, Ombati R, Chen J, Lu X, Cui J, Lu Q, Zhang L, Zhou M, Tian C, Yang S, Lai R
ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2.
1. Elife - published January 2, 2018
2. Jain D, Puno MR, Meydan C, Lailler N, Mason CE, Lima CD, Anderson KV, Keeney S
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
1. Cell Death Differ - published January 2, 2018
2. Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G
Three-dimensional spatial analysis of missense variants in RTEL1 identifies pathogenic variants in patients with Familial Interstitial Pneumonia.
1. BMC Bioinformatics - published January 2, 2018
2. Sivley RM, Sheehan JH, Kropski JA, Cogan J, Blackwell TS, Phillips JA, Bush WS, Meiler J, Capra JA
The diamond anniversary of tissue transglutaminase: a protein of many talents.
1. Drug Discov Today - published January 2, 2018
2. Katt WP, Antonyak MA, Cerione RA
Critical neutralizing fragment of Zika virus EDIII elicits cross-neutralization and protection against divergent Zika viruses.
1. Emerg Microbes Infect - published January 2, 2018
2. Tai W, He L, Wang Y, Sun S, Zhao G, Luo C, Li P, Zhao H, Fremont DH, Li F, Jiang S, Zhou Y, Du L
Achieving Skeletal Diversity in Peptide Macrocycles Through The Use of Heterocyclic Grafts.
1. Chemistry - published January 2, 2018
2. Kaldas SJ, Yudin AK
New Opportunities Created by Single-Particle Cryo-EM: The Mapping of Conformational Space.
1. Biochemistry - published January 2, 2018
2. Frank J
The life of U6 small nuclear RNA, from cradle to grave.
1. RNA - published January 2, 2018
2. Didychuk AL, Butcher SE, Brow DA
Mixed pyruvate labeling enables backbone resonance assignment of large proteins using a single experiment.
1. Nat Commun - published January 2, 2018
2. Robson SA, Takeuchi K, Boeszoermenyi A, Coote PW, Dubey A, Hyberts S, Wagner G, Arthanari H
Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation.
1. Science - published January 2, 2018
2. Kim Y, Chen J
Characterization of Nanodiamond-based anti-HIV drug Delivery to the Brain.
1. Sci Rep - published January 2, 2018
2. Roy U, Drozd V, Durygin A, Rodriguez J, Barber P, Atluri V, Liu X, Voss TG, Saxena S, Nair M
Molecular Mechanism and Evolution of Nuclear Pre-mRNA and Group II Intron Splicing: Insights from Cryo-Electron Microscopy Structures.
1. Chem Rev - published January 2, 2018
2. Galej WP, Toor N, Newman AJ, Nagai K
Facile Synthesis, Geometry, and 2'-Substituent-Dependent in Vivo Activity of 5'-(E)- and 5'-(Z)-Vinylphosphonate-Modified siRNA Conjugates.
1. J Med Chem - published January 2, 2018
2. Parmar RG, Brown CR, Matsuda S, Willoughby JLS, Theile CS, Charissé K, Foster DJ, Zlatev I, Jadhav V, Maier MA, Egli M, Manoharan M, Rajeev KG
High integrin αVβ6 affinity reached by hybrid domain deletion slows ligand-binding on-rate.
1. Proc Natl Acad Sci U S A - published January 2, 2018
2. Dong X, Zhao B, Lin FY, Lu C, Rogers BN, Springer TA
Comparative Nucleotide-Dependent Interactome Analysis Reveals Shared and Differential Properties of KRas4a and KRas4b.
1. ACS Cent Sci - published January 2, 2018
2. Zhang X, Cao J, Miller SP, Jing H, Lin H
Karyopherins in cancer.
1. Curr Opin Cell Biol - published January 2, 2018
2. Çağatay T, Chook YM
Nuclear phosphoinositide regulation of chromatin.
1. J Cell Physiol - published January 1, 2018
2. Hamann BL, Blind RD
BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes.
1. Mucosal Immunol - published January 1, 2018
2. Ehlers A, Xie W, Agapov E, Brown S, Steinberg D, Tidwell R, Sajol G, Schutz R, Weaver R, Yu H, Castro M, Bacharier LB, Wang X, Holtzman MJ, Haspel JA
Exercise training increases skeletal muscle mitochondrial volume density by enlargement of existing mitochondria and not de novo biogenesis.
1. Acta Physiol (Oxf) - published January 1, 2018
2. Meinild Lundby AK, Jacobs RA, Gehrig S, de Leur J, Hauser M, Bonne TC, Flück D, Dandanell S, Kirk N, Kaech A, Ziegler U, Larsen S, Lundby C
On the structure and mechanism of two-pore channels.
1. FEBS J - published January 1, 2018
2. Kintzer AF, Stroud RM
Nuclear Lamins: Thin Filaments with Major Functions.
1. Trends Cell Biol - published January 1, 2018
2. de Leeuw R, Gruenbaum Y, Medalia O
An epoxide hydrolase secreted by Pseudomonas aeruginosa decreases mucociliary transport and hinders bacterial clearance from the lung.
1. Am J Physiol Lung Cell Mol Physiol - published January 1, 2018
2. Hvorecny KL, Dolben E, Moreau-Marquis S, Hampton TH, Shabaneh TB, Flitter BA, Bahl CD, Bomberger JM, Levy BD, Stanton BA, Hogan DA, Madden DR
mRNA transport in fungal top models.
1. Wiley Interdiscip Rev RNA - published January 1, 2018
2. Niessing D, Jansen RP, Pohlmann T, Feldbrügge M
NS3 from Hepatitis C Virus Strain JFH-1 Is an Unusually Robust Helicase That Is Primed To Bind and Unwind Viral RNA.
1. J Virol - published January 1, 2018
2. Zhou T, Ren X, Adams RL, Pyle AM
Distinguishing signal from autofluorescence in cryogenic correlated light and electron microscopy of mammalian cells.
1. J Struct Biol - published January 1, 2018
2. Carter SD, Mageswaran SK, Farino ZJ, Mamede JI, Oikonomou CM, Hope TJ, Freyberg Z, Jensen GJ
Computational design of membrane proteins using RosettaMembrane.
1. Protein Sci - published January 1, 2018
2. Duran AM, Meiler J
Ex Uno Plura: Differential Labeling of Phospholipid Biosynthetic Pathways with a Single Bioorthogonal Alcohol.
1. Biochemistry - published January 1, 2018
2. Bumpus TW, Liang FJ, Baskin JM
Biophysical characterization of the basic cluster in the transcription repression domain of human MeCP2 with AT-rich DNA.
1. Biochem Biophys Res Commun - published January 1, 2018
2. Mushtaq AU, Lee Y, Hwang E, Bang JK, Hong E, Byun Y, Song JJ, Jeon YH
Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions.
1. Nat Mater - published January 1, 2018
2. Nakamura H, Lee AA, Afshar AS, Watanabe S, Rho E, Razavi S, Suarez A, Lin YC, Tanigawa M, Huang B, DeRose R, Bobb D, Hong W, Gabelli SB, Goutsias J, Inoue T
Overexpression of a newly identified d-amino acid transaminase in Mycobacterium smegmatis complements glutamate racemase deletion.
1. Mol Microbiol - published January 1, 2018
2. Mortuza R, Aung HL, Taiaroa G, Opel-Reading HK, Kleffmann T, Cook GM, Krause KL
PEM-fitter: A Coarse-Grained Method to Validate Protein Candidate Models.
1. J Comput Biol - published January 1, 2018
2. Al Nasr K, Jones C, Yousef F, Jebril R
A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells.
1. J Biol Chem - published January 1, 2018
2. Kroh HK, Chandrasekaran R, Zhang Z, Rosenthal K, Woods R, Jin X, Nyborg AC, Rainey GJ, Warrener P, Melnyk RA, Spiller BW, Lacy DB
Structural insights into the oligomerization of FtsH periplasmic domain from Thermotoga maritima.
1. Biochem Biophys Res Commun - published January 1, 2018
2. An JY, Sharif H, Kang GB, Park KJ, Lee JG, Lee S, Jin MS, Song JJ, Wang J, Eom SH
Profile of Joachim Frank, Richard Henderson, and Jacques Dubochet, 2017 Nobel Laureates in Chemistry.
1. Proc Natl Acad Sci U S A - published January 1, 2018
2. Nogales E
Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR.
1. Nat Protoc - published January 1, 2018
2. Hagn F, Nasr ML, Wagner G
X-rays in the Cryo-Electron Microscopy Era: Structural Biology's Dynamic Future.
1. Biochemistry - published January 1, 2018
2. Shoemaker SC, Ando N
Human viperin catalyzes the modification of GPP and FPP potentially affecting cholesterol synthesis.
1. FEBS Lett - published January 1, 2018
2. Mikulecky P, Andreeva E, Amara P, Weissenhorn W, Nicolet Y, Macheboeuf P
Identification of a ubiquitin-binding interface using Rosetta and DEER.
1. Proc Natl Acad Sci U S A - published January 1, 2018
2. Tessmer MH, Anderson DM, Pickrum AM, Riegert MO, Moretti R, Meiler J, Feix JB, Frank DW
A Single Amide Linkage in the Passenger Strand Suppresses Its Activity and Enhances Guide Strand Targeting of siRNAs.
1. ACS Chem Biol - published January 1, 2018
2. Hardcastle T, Novosjolova I, Kotikam V, Cheruiyot SK, Mutisya D, Kennedy SD, Egli M, Kelley ML, Smith AVB, Rozners E
Dual Allosteric Inhibition of SHP2 Phosphatase.
1. ACS Chem Biol - published January 1, 2018
2. Fodor M, Price E, Wang P, Lu H, Argintaru A, Chen Z, Glick M, Hao HX, Kato M, Koenig R, LaRochelle JR, Liu G, McNeill E, Majumdar D, Nishiguchi GA, Perez LB, Paris G, Quinn CM, Ramsey T, Sendzik M, Shultz MD, Williams SL, Stams T, Blacklow SC, Acker MG, LaMarche MJ
Special Issue Preface: The 9th Computational Structural Bioinformatics Workshop.
1. J Comput Biol - published January 1, 2018
2. He J, Al Nasr K, Sun W, Lu Y
The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding.
1. Cell Host Microbe - published January 1, 2018
2. King LB, Fusco ML, Flyak AI, Ilinykh PA, Huang K, Gunn B, Kirchdoerfer RN, Hastie KM, Sangha AK, Meiler J, Alter G, Bukreyev A, Crowe JE Jr, Saphire EO
TRPM channels come into focus.
1. Science - published January 1, 2018
2. Bae C, Jara-Oseguera A, Swartz KJ
Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer.
1. Sci Adv - published January 1, 2018
2. Bhuripanyo K, Wang Y, Liu X, Zhou L, Liu R, Duong D, Zhao B, Bi Y, Zhou H, Chen G, Seyfried NT, Chazin WJ, Kiyokawa H, Yin J
Chemical genomic guided engineering of gamma-valerolactone tolerant yeast.
1. Microb Cell Fact - published January 1, 2018
2. Bottoms S, Dickinson Q, McGee M, Hinchman L, Higbee A, Hebert A, Serate J, Xie D, Zhang Y, Coon JJ, Myers CL, Landick R, Piotrowski JS
Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp.
1. Nat Struct Mol Biol - published January 1, 2018
2. Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, Gonen T, Rodriguez JA
Structural Basis of Heterochromatin Formation by Human HP1.
1. Mol Cell - published January 1, 2018
2. Machida S, Takizawa Y, Ishimaru M, Sugita Y, Sekine S, Nakayama JI, Wolf M, Kurumizaka H
Cytocapsular tubes conduct cell translocation.
1. Proc Natl Acad Sci U S A - published January 1, 2018
2. Yi T, Wagner G
Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.
1. Proc Natl Acad Sci U S A - published January 1, 2018
2. Rezaei Araghi R, Bird GH, Ryan JA, Jenson JM, Godes M, Pritz JR, Grant RA, Letai A, Walensky LD, Keating AE
Automation aided optimization of cloning, expression and purification of enzymes of the bacterial sialic acid catabolic and sialylation pathways enzymes for structural studies.
1. Microb Biotechnol - published January 1, 2018
2. Bairy S, Gopalan LN, Setty TG, Srinivasachari S, Manjunath L, Kumar JP, Guntupalli SR, Bose S, Nayak V, Ghosh S, Sathyanarayanan N, Caing-Carlsson R, Wahlgren WY, Friemann R, Ramaswamy S, Neerathilingam M
Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation.
1. EMBO J - published January 1, 2018
2. Le VQ, Iacob RE, Tian Y, McConaughy W, Jackson J, Su Y, Zhao B, Engen JR, Pirruccello-Straub M, Springer TA
Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural Insight.
1. Biochemistry - published January 1, 2018
2. Green KD, Biswas T, Pang AH, Willby MJ, Reed MS, Stuchlik O, Pohl J, Posey JE, Tsodikov OV, Garneau-Tsodikova S
Cellular and Humoral Immunity Protect against Vaginal Zika Virus Infection in Mice.
1. J Virol - published January 1, 2018
2. Scott JM, Lebratti TJ, Richner JM, Jiang X, Fernandez E, Zhao H, Fremont DH, Diamond MS, Shin H
Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.
1. Immunity - published January 1, 2018
2. McCarthy KR, Watanabe A, Kuraoka M, Do KT, McGee CE, Sempowski GD, Kepler TB, Schmidt AG, Kelsoe G, Harrison SC
Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A.
1. PLoS Negl Trop Dis - published January 1, 2018
2. Harigua-Souiai E, Abdelkrim YZ, Bassoumi-Jamoussi I, Zakraoui O, Bouvier G, Essafi-Benkhadir K, Banroques J, Desdouits N, Munier-Lehmann H, Barhoumi M, Tanner NK, Nilges M, Blondel A, Guizani I
Crystal structure of an assembly intermediate of respiratory Complex II.
1. Nat Commun - published January 1, 2018
2. Sharma P, Maklashina E, Cecchini G, Iverson TM
High-resolution structures of mitochondrial ribosomes and their functional implications.
1. Curr Opin Struct Biol - published January 1, 2018
2. Bieri P, Greber BJ, Ban N
Thiosulfate Sulfurtransferase like Domain Containing 1 Protein Interacts with Thioredoxin.
1. J Biol Chem - published January 1, 2018
2. Libiad M, Motl N, Akey DL, Sakamoto N, Fearon ER, Smith JL, Banerjee R
Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development.
1. Nat Commun - published January 1, 2018
2. Krishnan N, Bonham CA, Rus IA, Shrestha OK, Gauss CM, Haque A, Tocilj A, Joshua-Tor L, Tonks NK
Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
1. Nat Commun - published January 1, 2018
2. Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein JE, Brenner S, Klein J, Jeridi A, Hoffmann A, Lee E, Dianzani U, Willemsen R, Feederle R, Reiche K, Hackermüller J, Leonhardt H, Sharma S, Niessing D, Heissmeyer V
Autologous stem cell therapy for inherited and acquired retinal disease.
1. Regen Med - published January 1, 2018
2. Apatoff MBL, Sengillo JD, White EC, Bakhoum MF, Bassuk AG, Mahajan VB, Tsang SH
Effect of platinum-based chemotherapy on EGFR gene mutation status in lung adenocarcinoma.
1. Medicine (Baltimore) - published January 1, 2018
2. Wang Y, Ma X, Wei Y, Ma D, Gong P
Production, biophysical characterization and initial crystallization studies of the N- and C-terminal domains of DsbD, an essential enzyme in Neisseria meningitidis.
1. Acta Crystallogr F Struct Biol Commun - published January 1, 2018
2. Smith RP, Whitten AE, Paxman JJ, Kahler CM, Scanlon MJ, Heras B
Bevacizumab Injection in Patients with Neovascular Age-Related Macular Degeneration Increases Angiogenic Biomarkers.
1. Ophthalmol Retina - published January 1, 2018
2. Cabral T, Lima LH, Mello LGM, Polido J, Correa ÉP, Oshima A, Duong J, Serracarbassa P, Regatieri CV, Mahajan VB, Belfort R Jr
Progesterone receptor isoforms, agonists and antagonists differentially reprogram estrogen signaling.
1. Oncotarget - published January 1, 2018
2. Singhal H, Greene ME, Zarnke AL, Laine M, Al Abosy R, Chang YF, Dembo AG, Schoenfelt K, Vadhi R, Qiu X, Rao P, Santhamma B, Nair HB, Nickisch KJ, Long HW, Becker L, Brown M, Greene GL
Immediate Breast Reconstruction among Patients with Medicare and Private Insurance: A Matched Cohort Analysis.
1. Plast Reconstr Surg Glob Open - published January 1, 2018
2. Kamali P, Ricci JA, Curiel DA, Cohen JB, Chattha A, Rakhorst HA, Lee BT, Lin SJ
Worldwide Protein Data Bank biocuration supporting open access to high-quality 3D structural biology data.
1. Database (Oxford) - published January 1, 2018
2. Young JY, Westbrook JD, Feng Z, Peisach E, Persikova I, Sala R, Sen S, Berrisford JM, Swaminathan GJ, Oldfield TJ, Gutmanas A, Igarashi R, Armstrong DR, Baskaran K, Chen L, Chen M, Clark AR, Di Costanzo L, Dimitropoulos D, Gao G, Ghosh S, Gore S, Guranovic V, Hendrickx PMS, Hudson BP, Ikegawa Y, Kengaku Y, Lawson CL, Liang Y, Mak L, Mukhopadhyay A, Narayanan B, Nishiyama K, Patwardhan A, Sahni G, Sanz-García E, Sato J, Sekharan MR, Shao C, Smart OS, Tan L, van Ginkel G, Yang H, Zhuravleva MA, Markley JL, Nakamura H, Kurisu G, Kleywegt GJ, Velankar S, Berman HM, Burley SK
The ER morphology-regulating lunapark protein induces the formation of stacked bilayer discs.
1. Life Sci Alliance - published January 1, 2018
2. Wang S, Powers RE, Gold VA, Rapoport TA