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130 Member Publications for December 2017

Structural and functional differences between porcine brain and budding yeast microtubules.
1. Cell Cycle - published December 28, 2017
2. Howes SC, Geyer EA, LaFrance B, Zhang R, Kellogg EH, Westermann S, Rice LM, Nogales E
Using thermal scanning assays to test protein-protein interactions of inner-ear cadherins.
1. PLoS One - published December 21, 2017
2. Choudhary D, Kumar A, Magliery TJ, Sotomayor M
Purification of Target Proteins from Native Tissues: CCT Complex from Bovine Testes and PP2Ac from Porcine Brains.
1. Methods Mol Biol - published December 17, 2017
2. Guo F, Wlodarchak N, Menden P, Xing Y
High Resolution Distance Distributions Determined by X-Ray and Neutron Scattering.
1. Adv Exp Med Biol - published December 9, 2017
2. Tang HYH, Tainer JA, Hura GL
Clinical Variants of New Delhi Metallo-β-Lactamase Are Evolving To Overcome Zinc Scarcity.
1. ACS Infect Dis - published December 8, 2017
2. Stewart AC, Bethel CR, VanPelt J, Bergstrom A, Cheng Z, Miller CG, Williams C, Poth R, Morris M, Lahey O, Nix JC, Tierney DL, Page RC, Crowder MW, Bonomo RA, Fast W
Structural basis for methylphosphonate biosynthesis.
1. Science - published December 8, 2017
2. Born DA, Ulrich EC, Ju KS, Peck SC, van der Donk WA, Drennan CL
"Just a spoonful of sugar...": import of sialic acid across bacterial cell membranes.
1. Biophys Rev - published December 8, 2017
2. North RA, Horne CR, Davies JS, Remus DM, Muscroft-Taylor AC, Goyal P, Wahlgren WY, Ramaswamy S, Friemann R, Dobson RCJ
CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing.
1. Nat Commun - published December 8, 2017
2. Moreno-Mateos MA, Fernandez JP, Rouet R, Vejnar CE, Lane MA, Mis E, Khokha MK, Doudna JA, Giraldez AJ
Photophysics of J-Aggregate-Mediated Energy Transfer on DNA.
1. J Phys Chem Lett - published December 7, 2017
2. Banal JL, Kondo T, Veneziano R, Bathe M, Schlau-Cohen GS
Crystal structures of ternary complexes of archaeal B-family DNA polymerases.
1. PLoS One - published December 7, 2017
2. Kropp HM, Betz K, Wirth J, Diederichs K, Marx A
The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion.
1. PLoS Pathog - published December 7, 2017
2. Richards AL, Sollars PJ, Pitts JD, Stults AM, Heldwein EE, Pickard GE, Smith GA
Structure of the human TRPM4 ion channel in a lipid nanodisc.
1. Science - published December 7, 2017
2. Autzen HE, Myasnikov AG, Campbell MG, Asarnow D, Julius D, Cheng Y
The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport.
1. J Am Chem Soc - published December 6, 2017
2. May JM, Owens TW, Mandler MD, Simpson BW, Lazarus MB, Sherman DJ, Davis RM, Okuda S, Massefski W, Ruiz N, Kahne D
KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase.
1. Nature - published December 6, 2017
2. Wang Y, Guo YR, Liu K, Yin Z, Liu R, Xia Y, Tan L, Yang P, Lee JH, Li XJ, Hawke D, Zheng Y, Qian X, Lyu J, He J, Xing D, Tao YJ, Lu Z
Economic policy and the double burden of malnutrition: cross-national longitudinal analysis of minimum wage and women's underweight and obesity.
1. Public Health Nutr - published December 6, 2017
2. Conklin AI, Ponce NA, Crespi CM, Frank J, Nandi A, Heymann J
Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes.
1. J Biol Chem - published December 6, 2017
2. Gonzalez E, Johnson KM, Pallan PS, Phan TTN, Zhang W, Lei LI, Wawrzak Z, Yoshimoto FK, Egli M, Guengerich FP
The crystal structure of pseudokinase PEAK1 (Sugen Kinase 269) reveals an unusual catalytic cleft and a novel mode of kinase fold dimerization.
1. J Biol Chem - published December 6, 2017
2. Ha BH, Boggon TJ
Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor.
1. Structure - published December 6, 2017
2. Harvey EP, Seo HS, Guerra RM, Bird GH, Dhe-Paganon S, Walensky LD
Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.
1. Structure - published December 5, 2017
2. Sangha AK, Dong J, Williamson L, Hashiguchi T, Saphire EO, Crowe JE Jr, Meiler J
Molecular basis for the recognition of the human AAUAAA polyadenylation signal.
1. Proc Natl Acad Sci U S A - published December 5, 2017
2. Sun Y, Zhang Y, Hamilton K, Manley JL, Shi Y, Walz T, Tong L
Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing.
1. Nat Commun - published December 5, 2017
2. Brulotte ML, Jeong BC, Li F, Li B, Yu EB, Wu Q, Brautigam CA, Yu H, Luo X
Bacteriophage T5 tail tube structure suggests a trigger mechanism for Siphoviridae DNA ejection.
1. Nat Commun - published December 5, 2017
2. Arnaud CA, Effantin G, Vivès C, Engilberge S, Bacia M, Boulanger P, Girard E, Schoehn G, Breyton C
Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains.
1. Cell Rep - published December 5, 2017
2. Joyce MG, Georgiev IS, Yang Y, Druz A, Geng H, Chuang GY, Kwon YD, Pancera M, Rawi R, Sastry M, Stewart-Jones GBE, Zheng A, Zhou T, Choe M, Van Galen JG, Chen RE, Lees CR, Narpala S, Chambers M, Tsybovsky Y, Baxa U, McDermott AB, Mascola JR, Kwong PD
Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome.
1. Proc Natl Acad Sci U S A - published December 5, 2017
2. Skinner JJ, Wang S, Lee J, Ong C, Sommese R, Sivaramakrishnan S, Koelmel W, Hirschbeck M, Schindelin H, Kisker C, Lorenz K, Sosnick TR, Rosner MR
Analysis of the quality of crystallographic data and the limitations of structural models.
1. J Gen Physiol - published December 4, 2017
2. Arkhipova V, Guskov A, Slotboom DJ
Stability and Water Accessibility of the Trimeric Membrane Anchors of the HIV-1 Envelope Spikes.
1. J Am Chem Soc - published December 4, 2017
2. Piai A, Dev J, Fu Q, Chou JJ
Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy.
1. J Exp Med - published December 4, 2017
2. Chheda ZS, Kohanbash G, Okada K, Jahan N, Sidney J, Pecoraro M, Yang X, Carrera DA, Downey KM, Shrivastav S, Liu S, Lin Y, Lagisetti C, Chuntova P, Watchmaker PB, Mueller S, Pollack IF, Rajalingam R, Carcaboso AM, Mann M, Sette A, Garcia KC, Hou Y, Okada H
Purification and functional comparison of nine human Aquaporins produced in Saccharomyces cerevisiae for the purpose of biophysical characterization.
1. Sci Rep - published December 4, 2017
2. Bjørkskov FB, Krabbe SL, Nurup CN, Missel JW, Spulber M, Bomholt J, Molbaek K, Helix-Nielsen C, Gotfryd K, Gourdon P, Pedersen PA
Corrigendum to "Differences in combinations and concentrations of drugs of abuse in fatal intoxication and driving under the influence cases" [Forensic Sci. Int. 281 (2017) 127-133].
1. Forensic Sci Int - published December 3, 2017
2. Edvardsen HE, Tverborgvik T, Frost J, Rogde S, Morild I, Waal H, Clausen T, Slørdal L, Vindenes V
Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution.
1. RNA Biol - published December 2, 2017
2. Ransey E, Björkbom A, Lelyveld VS, Biecek P, Pantano L, Szostak JW, Sliz P
Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium.
1. J Biol Chem - published December 2, 2017
2. Cook JD, Ng SY, Lloyd M, Eddington S, Sun H, Nathans J, Bok D, Radu RA, Travis GH
Structure Determination of a Water-Soluble 144-Gold Atom Particle at Atomic Resolution by Aberration-Corrected Electron Microscopy.
1. ACS Nano - published December 2, 2017
2. Azubel M, Koh AL, Koyasu K, Tsukuda T, Kornberg RD
The Autophagy-Related Beclin-1 Protein Requires the Coiled-Coil and BARA Domains To Form a Homodimer with Submicromolar Affinity.
1. Biochemistry - published December 2, 2017
2. Ranaghan MJ, Durney MA, Mesleh MF, McCarren PR, Garvie CW, Daniels DS, Carey KL, Skepner AP, Levine B, Perez JR
Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
1. Nature - published December 2, 2017
2. Yang H, Jiang X, Li B, Yang HJ, Miller M, Yang A, Dhar A, Pavletich NP
Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes.
1. J Biol Chem - published December 2, 2017
2. Moody RR, Lo MC, Meagher JL, Lin CC, Stevers NO, Tinsley SL, Jung I, Matvekas A, Stuckey JA, Sun D
Folding DNA into a lipid-conjugated nano-barrel for controlled reconstitution of membrane proteins.
1. Angew Chem Int Ed Engl - published December 2, 2017
2. Dong Y, Chen S, Zhang S, Sodroski J, Yang Z, Liu D, Mao Y
Therapeutic drug repositioning using personalized proteomics of liquid biopsies.
1. JCI Insight - published December 2, 2017
2. Velez G, Bassuk AG, Colgan D, Tsang SH, Mahajan VB
β-Arrestin2 mediates progression of murine primary myelofibrosis.
1. JCI Insight - published December 2, 2017
2. Rein LA, Wisler JW, Kim J, Theriot B, Huang L, Price T, Yang H, Chen M, Chen W, Sipkins D, Fedoriw Y, Walker JK, Premont RT, Lefkowitz RJ
Molecular Architectures of Pen and Pal: Key Enzymes Required for CMP-Pseudaminic Acid Biosynthesis in Bacillus thuringiensis.
1. Protein Sci - published December 2, 2017
2. Delvaux NA, Thoden JB, Holden HM
Conjugative transposition of the vancomycin resistance carrying Tn1549: enzymatic requirements and target site preferences.
1. Mol Microbiol - published December 2, 2017
2. Lambertsen L, Rubio-Cosials A, Patil KR, Barabas O
Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions.
1. Nat Commun - published December 2, 2017
2. Yang B, Tang S, Ma C, Li ST, Shao GC, Dang B, DeGrado WF, Dong MQ, Wang PG, Ding S, Wang L
Using cellular fitness to map the structure and function of a major facilitator superfamily effluxer.
1. Mol Syst Biol - published December 2, 2017
2. Perez AM, Gomez MM, Kalvapalle P, O'Brien-Gilbert E, Bennett MR, Shamoo Y
Methylation-regulated decommissioning of multimeric PP2A complexes.
1. Nat Commun - published December 2, 2017
2. Wu CG, Zheng A, Jiang L, Rowse M, Stanevich V, Chen H, Li Y, Satyshur KA, Johnson B, Gu TJ, Liu Z, Xing Y
Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex.
1. Elife - published December 2, 2017
2. Clerici M, Faini M, Aebersold R, Jinek M
Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes.
1. Cell - published December 2, 2017
2. Gee MH, Han A, Lofgren SM, Beausang JF, Mendoza JL, Birnbaum ME, Bethune MT, Fischer S, Yang X, Gomez-Eerland R, Bingham DB, Sibener LV, Fernandes RA, Velasco A, Baltimore D, Schumacher TN, Khatri P, Quake SR, Davis MM, Garcia KC
Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor.
1. Cell - published December 2, 2017
2. Barrow AD, Edeling MA, Trifonov V, Luo J, Goyal P, Bohl B, Bando JK, Kim AH, Walker J, Andahazy M, Bugatti M, Melocchi L, Vermi W, Fremont DH, Cox S, Cella M, Schmedt C, Colonna M
Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum.
1. Cell Rep - published December 2, 2017
2. Anghel SA, McGilvray PT, Hegde RS, Keenan RJ
Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes.
1. Cell Rep - published December 2, 2017
2. Stern JL, Paucek RD, Huang FW, Ghandi M, Nwumeh R, Costello JC, Cech TR
Decoding the centromeric nucleosome through CENP-N.
1. Elife - published December 2, 2017
2. Pentakota S, Zhou K, Smith C, Maffini S, Petrovic A, Morgan GP, Weir JR, Vetter IR, Musacchio A, Luger K
Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models.
1. Cell Rep - published December 2, 2017
2. Saunders KO, Verkoczy LK, Jiang C, Zhang J, Parks R, Chen H, Housman M, Bouton-Verville H, Shen X, Trama AM, Scearce R, Sutherland L, Santra S, Newman A, Eaton A, Xu K, Georgiev IS, Joyce MG, Tomaras GD, Bonsignori M, Reed SG, Salazar A, Mascola JR, Moody MA, Cain DW, Centlivre M, Zurawski S, Zurawski G, Erickson HP, Kwong PD, Alam SM, Levy Y, Montefiori DC, Haynes BF
Heat activation is intrinsic to the pore domain of TRPV1.
1. Proc Natl Acad Sci U S A - published December 2, 2017
2. Zhang F, Jara-Oseguera A, Chang TH, Bae C, Hanson SM, Swartz KJ
From in silico hit to long-acting late-stage preclinical candidate to combat HIV-1 infection.
1. Proc Natl Acad Sci U S A - published December 2, 2017
2. Kudalkar SN, Beloor J, Quijano E, Spasov KA, Lee WG, Cisneros JA, Saltzman WM, Kumar P, Jorgensen WL, Anderson KS
Common fibrillar spines of amyloid-β and human Islet Amyloid Polypeptide revealed by Micro Electron Diffraction and inhibitors developed using structure-based design.
1. J Biol Chem - published December 2, 2017
2. Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS
Molecular structure of human KATP in complex with ATP and ADP.
1. Elife - published December 2, 2017
2. Lee KPK, Chen J, MacKinnon R
ATP Binding Enables Substrate Release from Multidrug Resistance Protein 1.
1. Cell - published December 2, 2017
2. Johnson ZL, Chen J
Hot Spots for Protein Partnerships at the Surface of Cholinesterases and Related α/β Hydrolase Fold Proteins or Domains-A Structural Perspective.
1. Molecules - published December 2, 2017
2. Bourne Y, Marchot P
Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models.
1. ACS Cent Sci - published December 2, 2017
2. Zimmerman MI, Hart KM, Sibbald CA, Frederick TE, Jimah JR, Knoverek CR, Tolia NH, Bowman GR
Novel protein acetyltransferase, Rv2170, modulates carbon and energy metabolism in Mycobacterium tuberculosis.
1. Sci Rep - published December 1, 2017
2. Lee W, VanderVen BC, Walker S, Russell DG
Towards a mechanistic understanding of core promoter recognition from cryo-EM studies of human TFIID.
1. Curr Opin Struct Biol - published December 1, 2017
2. Nogales E, Patel AB, Louder RK
Live and let die: insights into pseudoenzyme mechanisms from structure.
1. Curr Opin Struct Biol - published December 1, 2017
2. Murphy JM, Mace PD, Eyers PA
Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the preribosomal protein Nop53.
1. RNA - published December 1, 2017
2. Falk S, Tants JN, Basquin J, Thoms M, Hurt E, Sattler M, Conti E
Mutations in the Fusion Protein of Measles Virus That Confer Resistance to the Membrane Fusion Inhibitors Carbobenzoxy-d-Phe-l-Phe-Gly and 4-Nitro-2-Phenylacetyl Amino-Benzamide.
1. J Virol - published December 1, 2017
2. Ha MN, Delpeut S, Noyce RS, Sisson G, Black KM, Lin LT, Bilimoria D, Plemper RK, Privé GG, Richardson CD
Vaccinia Virus Encodes a Novel Inhibitor of Apoptosis That Associates with the Apoptosome.
1. J Virol - published December 1, 2017
2. Ryerson MR, Richards MM, Kvansakul M, Hawkins CJ, Shisler JL
H-IPSE Is a Pathogen-Secreted Host Nucleus-Infiltrating Protein (Infiltrin) Expressed Exclusively by the Schistosoma haematobium Egg Stage.
1. Infect Immun - published December 1, 2017
2. Pennington LF, Alouffi A, Mbanefo EC, Ray D, Heery DM, Jardetzky TS, Hsieh MH, Falcone FH
Epstein-Barr Virus Fusion with Epithelial Cells Triggered by gB Is Restricted by a gL Glycosylation Site.
1. J Virol - published December 1, 2017
2. Möhl BS, Chen J, Park SJ, Jardetzky TS, Longnecker R
Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.
1. Antimicrob Agents Chemother - published December 1, 2017
2. Nakatani Y, Opel-Reading HK, Merker M, Machado D, Andres S, Kumar SS, Moradigaravand D, Coll F, Perdigão J, Portugal I, Schön T, Nair D, Devi KRU, Kohl TA, Beckert P, Clark TG, Maphalala G, Khumalo D, Diel R, Klaos K, Aung HL, Cook GM, Parkhill J, Peacock SJ, Swaminathan S, Viveiros M, Niemann S, Krause KL, Köser CU
Prior Dengue Virus Exposure Shapes T Cell Immunity to Zika Virus in Humans.
1. J Virol - published December 1, 2017
2. Grifoni A, Pham J, Sidney J, O'Rourke PH, Paul S, Peters B, Martini SR, de Silva AD, Ricciardi MJ, Magnani DM, Silveira CGT, Maestri A, Costa PR, de-Oliveira-Pinto LM, de Azeredo EL, Damasco PV, Phillips E, Mallal S, de Silva AM, Collins M, Durbin A, Diehl SA, Cerpas C, Balmaseda A, Kuan G, Coloma J, Harris E, Crowe JE Jr, Stone M, Norris PJ, Busch M, Vivanco-Cid H, Cox J, Graham BS, Ledgerwood JE, Turtle L, Solomon T, Kallas EG, Watkins DI, Weiskopf D, Sette A
Structure of the calcium-dependent type 2 secretion pseudopilus.
1. Nat Microbiol - published December 1, 2017
2. López-Castilla A, Thomassin JL, Bardiaux B, Zheng W, Nivaskumar M, Yu X, Nilges M, Egelman EH, Izadi-Pruneyre N, Francetic O
Tubulin isoform composition tunes microtubule dynamics.
1. Mol Biol Cell - published December 1, 2017
2. Vemu A, Atherton J, Spector JO, Moores CA, Roll-Mecak A
Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer.
1. Cancer Discov - published December 1, 2017
2. Gettinger S, Choi J, Hastings K, Truini A, Datar I, Sowell R, Wurtz A, Dong W, Cai G, Melnick MA, Du VY, Schlessinger J, Goldberg SB, Chiang A, Sanmamed MF, Melero I, Agorreta J, Montuenga LM, Lifton R, Ferrone S, Kavathas P, Rimm DL, Kaech SM, Schalper K, Herbst RS, Politi K
Nitrosopumilus maritimus gen. nov., sp. nov., Nitrosopumilus cobalaminigenes sp. nov., Nitrosopumilus oxyclinae sp. nov., and Nitrosopumilus ureiphilus sp. nov., four marine ammonia-oxidizing archaea of the phylum Thaumarchaeota.
1. Int J Syst Evol Microbiol - published December 1, 2017
2. Qin W, Heal KR, Ramdasi R, Kobelt JN, Martens-Habbena W, Bertagnolli AD, Amin SA, Walker CB, Urakawa H, Könneke M, Devol AH, Moffett JW, Armbrust EV, Jensen GJ, Ingalls AE, Stahl DA
Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference.
1. Nucleic Acids Res - published December 1, 2017
2. Tants JN, Fesser S, Kern T, Stehle R, Geerlof A, Wunderlich C, Juen M, Hartlmüller C, Böttcher R, Kunzelmann S, Lange O, Kreutz C, Förstemann K, Sattler M
Synthesis of 5'-Thio-3'-O-ribonucleoside Phosphoramidites.
1. J Org Chem - published December 1, 2017
2. Li NS, Lu J, Piccirilli JA
Text Messaging for Improving Antiretroviral Therapy Adherence: No Effects After 1 Year in a Randomized Controlled Trial Among Adolescents and Young Adults.
1. Am J Public Health - published December 1, 2017
2. Linnemayr S, Huang H, Luoto J, Kambugu A, Thirumurthy H, Haberer JE, Wagner G, Mukasa B
Molecular basis for inner kinetochore configuration through RWD domain-peptide interactions.
1. EMBO J - published December 1, 2017
2. Schmitzberger F, Richter MM, Gordiyenko Y, Robinson CV, Dadlez M, Westermann S
Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA.
1. Nat Struct Mol Biol - published December 1, 2017
2. Wang X, Paucek RD, Gooding AR, Brown ZZ, Ge EJ, Muir TW, Cech TR
Mutations in RNA methylating enzymes in disease.
1. Curr Opin Chem Biol - published December 1, 2017
2. Stojković V, Fujimori DG
Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX.
1. J Biol Chem - published December 1, 2017
2. Lim KYB, Gödde NJ, Humbert PO, Kvansakul M
Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.
1. Mol Pharmacol - published December 1, 2017
2. Bouley R, Waldschmidt HV, Cato MC, Cannavo A, Song J, Cheung JY, Yao XQ, Koch WJ, Larsen SD, Tesmer JJG
Atom-Specific Mutagenesis Reveals Structural and Catalytic Roles for an Active-Site Adenosine and Hydrated Mg²⁺ in Pistol Ribozymes.
1. Angew Chem Int Ed Engl - published December 1, 2017
2. Neuner S, Falschlunger C, Fuchs E, Himmelstoss M, Ren A, Patel DJ, Micura R
Crystal and NMR Structures of a Peptidomimetic β-Turn That Provides Facile Synthesis of 13-Membered Cyclic Tetrapeptides.
1. Chem Asian J - published December 1, 2017
2. Cameron AJ, Squire CJ, Edwards PJB, Harjes E, Sarojini V
Structure-based mechanistic insights into catalysis by small self-cleaving ribozymes.
1. Curr Opin Chem Biol - published December 1, 2017
2. Ren A, Micura R, Patel DJ
Molecular architectures and mechanisms of Class 2 CRISPR-associated nucleases.
1. Curr Opin Struct Biol - published December 1, 2017
2. Garcia-Doval C, Jinek M
Determinants and Expansion of Specificity in a Trichothecene UDP-Glucosyltransferase from Oryza sativa.
1. Biochemistry - published December 1, 2017
2. Wetterhorn KM, Gabardi K, Michlmayr H, Malachova A, Busman M, McCormick SP, Berthiller F, Adam G, Rayment I
Tyrocidine A Analogues Bearing the Planar d-Phe-2-Abz Turn Motif: How Conformation Impacts Bioactivity.
1. J Med Chem - published December 1, 2017
2. Cameron AJ, Edwards PJB, Harjes E, Sarojini V
Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.
1. Cell - published December 1, 2017
2. Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey JM, Yu Y, Liu X, He L, Cavaliere PM, Chavez A, Zhang E, Isik M, Couvillon A, Dephoure NE, Blackwell TK, Yu JJ, Rabinowitz JD, Cantley LC, Blenis J
Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.
1. Stem Cell Reports - published December 1, 2017
2. Muratore CR, Zhou C, Liao M, Fernandez MA, Taylor WM, Lagomarsino VN, Pearse RV 2nd, Rice HC, Negri JM, He A, Srikanth P, Callahan DG, Shin T, Zhou M, Bennett DA, Noggle S, Love JC, Selkoe DJ, Young-Pearse TL
The development of cryo-EM and how it has advanced microbiology.
1. Nat Microbiol - published December 1, 2017
2. Oikonomou CM, Jensen GJ
Allosteric Modulation of Grb2 Recruitment to the Intrinsically Disordered Scaffold Protein, LAT, by Remote Site Phosphorylation.
1. J Am Chem Soc - published December 1, 2017
2. Huang WYC, Ditlev JA, Chiang HK, Rosen MK, Groves JT
CRISPR Repair Reveals Causative Mutation in a Preclinical Model of Retinitis Pigmentosa: A Brief Methodology.
1. Methods Mol Biol - published December 1, 2017
2. Wu WH, Tsai YT, Justus S, Cho GY, Sengillo JD, Xu Y, Cabral T, Lin CS, Bassuk AG, Mahajan VB, Tsang SH
Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.
1. Immunity - published December 1, 2017
2. Triller G, Scally SW, Costa G, Pissarev M, Kreschel C, Bosch A, Marois E, Sack BK, Murugan R, Salman AM, Janse CJ, Khan SM, Kappe SHI, Adegnika AA, Mordmüller B, Levashina EA, Julien JP, Wardemann H
The repeat region of cortactin is intrinsically disordered in solution.
1. Sci Rep - published December 1, 2017
2. Li X, Tao Y, Murphy JW, Scherer AN, Lam TT, Marshall AG, Koleske AJ, Boggon TJ
Meditope-Fab interaction: threading the hole.
1. Acta Crystallogr F Struct Biol Commun - published December 1, 2017
2. Bzymek KP, Ma Y, Avery KN, Horne DA, Williams JC
Structures of the calcium-activated, non-selective cation channel TRPM4.
1. Nature - published December 1, 2017
2. Guo J, She J, Zeng W, Chen Q, Bai XC, Jiang Y
Editorial overview: Protein-nucleic acid interactions: An expanding universe.
1. Curr Opin Struct Biol - published December 1, 2017
2. Cusack S, Müller CW
Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration.
1. Nat Commun - published December 1, 2017
2. Nordenfelt P, Moore TI, Mehta SB, Kalappurakkal JM, Swaminathan V, Koga N, Lambert TJ, Baker D, Waters JC, Oldenbourg R, Tani T, Mayor S, Waterman CM, Springer TA
Architecture of the human PI4KIIIα lipid kinase complex.
1. Proc Natl Acad Sci U S A - published December 1, 2017
2. Lees JA, Zhang Y, Oh MS, Schauder CM, Yu X, Baskin JM, Dobbs K, Notarangelo LD, De Camilli P, Walz T, Reinisch KM
Erratum to: Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR.
1. J Biomol NMR - published December 1, 2017
2. Takeuchi K, Arthanari H, Shimada I, Wagner G
Structure-based prediction of ligand-protein interactions on a genome-wide scale.
1. Proc Natl Acad Sci U S A - published December 1, 2017
2. Hwang H, Dey F, Petrey D, Honig B
Structure-based membrane dome mechanism for Piezo mechanosensitivity.
1. Elife - published December 1, 2017
2. Guo YR, MacKinnon R
An Exhaustive Search Algorithm to Aid NMR-Based Structure Determination of Rotationally Symmetric Transmembrane Oligomers.
1. Sci Rep - published December 1, 2017
2. Yang J, Piai A, Shen HB, Chou JJ
Disabling a Type I-E CRISPR-Cas Nuclease with a Bacteriophage-Encoded Anti-CRISPR Protein.
1. mBio - published December 1, 2017
2. Pawluk A, Shah M, Mejdani M, Calmettes C, Moraes TF, Davidson AR, Maxwell KL
Cryo-EM structures of the TMEM16A calcium-activated chloride channel.
1. Nature - published December 1, 2017
2. Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Nung Jan Y, Minor DL Jr, Cheng Y, Yeh Jan L
Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase.
1. Nat Commun - published December 1, 2017
2. Abplanalp J, Leutert M, Frugier E, Nowak K, Feurer R, Kato J, Kistemaker HVA, Filippov DV, Moss J, Caflisch A, Hottiger MO
Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM.
1. Nature - published December 1, 2017
2. Paulino C, Kalienkova V, Lam AKM, Neldner Y, Dutzler R
KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation.
1. Biochemistry - published December 1, 2017
2. Lu J, Bera A, Gondi SR, Westover KD
Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells.
1. Sci Rep - published December 1, 2017
2. Lis C, Rubner S, Roatsch M, Berg A, Gilcrest T, Fu D, Nguyen E, Schmidt AM, Krautscheid H, Meiler J, Berg T
Probing the requirement for CD38 in retinoic acid-induced HL-60 cell differentiation with a small molecule dimerizer and genetic knockout.
1. Sci Rep - published December 1, 2017
2. MacDonald RJ, Shrimp JH, Jiang H, Zhang L, Lin H, Yen A
INHIBITION OF DIVERSE DsbA ENZYMES IN MULTI-DsbA ENCODING PATHOGENS.
1. Antioxid Redox Signal - published December 1, 2017
2. Totsika M, Vagenas D, Paxman JJ, Wang G, Dhouib R, Sharma P, Martin JL, Scanlon MJ, Heras B
SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a.
1. Elife - published December 1, 2017
2. Jing H, Zhang X, Wisner SA, Chen X, Spiegelman NA, Linder ME, Lin H
Narrowing the spectrum: the new frontier of precision antimicrobials.
1. Genome Med - published December 1, 2017
2. Paharik AE, Schreiber HL 4th, Spaulding CN, Dodson KW, Hultgren SJ
Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation.
1. PLoS Genet - published December 1, 2017
2. Siller SS, Sharma H, Li S, Yang J, Zhang Y, Holtzman MJ, Winuthayanon W, Colognato H, Holdener BC, Li FQ, Takemaru KI
Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy.
1. Cell - published December 1, 2017
2. Palmer AC, Sorger PK
Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope.
1. Cell Rep - published December 1, 2017
2. Avnir Y, Prachanronarong KL, Zhang Z, Hou S, Peterson EC, Sui J, Zayed H, Kurella VB, McGuire AT, Stamatatos L, Hilbert BJ, Bohn MF, Kowalik TF, Jensen JD, Finberg RW, Wang JP, Goodall M, Jefferis R, Zhu Q, Kurt Yilmaz N, Schiffer CA, Marasco WA
Development of the Precision Link Biobank at Boston Children's Hospital: Challenges and Opportunities.
1. J Pers Med - published December 1, 2017
2. Bourgeois FT, Avillach P, Kong SW, Heinz MM, Tran TA, Chakrabarty R, Bickel J, Sliz P, Borglund EM, Kornetsky S, Mandl KD
Phospholipid flipping involves a central cavity in P4 ATPases.
1. Sci Rep - published December 1, 2017
2. Jensen MS, Costa SR, Duelli AS, Andersen PA, Poulsen LR, Stanchev LD, Gourdon P, Palmgren M, Günther Pomorski T, López-Marqués RL
The tunable pReX expression vector enables optimizing the T7-based production of membrane and secretory proteins in E. coli.
1. Microb Cell Fact - published December 1, 2017
2. Kuipers G, Karyolaimos A, Zhang Z, Ismail N, Trinco G, Vikström D, Slotboom DJ, de Gier JW
Recent advances in the synthesis of cyclic pseudopeptides.
1. Drug Discov Today Technol - published December 1, 2017
2. Zaretsky S, Yudin AK
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.
1. Nat Chem Biol - published December 1, 2017
2. Olson CM, Jiang B, Erb MA, Liang Y, Doctor ZM, Zhang Z, Zhang T, Kwiatkowski N, Boukhali M, Green JL, Haas W, Nomanbhoy T, Fischer ES, Young RA, Bradner JE, Winter GE, Gray NS
Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway.
1. Nat Immunol - published December 1, 2017
2. Holze C, Michaudel C, Mackowiak C, Haas DA, Benda C, Hubel P, Pennemann FL, Schnepf D, Wettmarshausen J, Braun M, Leung DW, Amarasinghe GK, Perocchi F, Staeheli P, Ryffel B, Pichlmair A
Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody.
1. Proc Natl Acad Sci U S A - published December 1, 2017
2. Raymond DD, Bajic G, Ferdman J, Suphaphiphat P, Settembre EC, Moody MA, Schmidt AG, Harrison SC
Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents.
1. J Med Chem - published December 1, 2017
2. Thamban Chandrika N, Shrestha SK, Ngo HX, Tsodikov OV, Howard KC, Garneau-Tsodikova S
Genome Surgery and Gene Therapy in Retinal Disorders.
1. Yale J Biol Med - published December 1, 2017
2. Chan L, Mahajan VB, Tsang SH
[The resolution revolution in cryo-electron microscopy].
1. Med Sci (Paris) - published December 1, 2017
2. Neumann E, Farias Estrozi L, Effantin G, Breyton C, Schoehn G
ER stress signaling promotes the survival of cancer 'persister cells' tolerant to EGFR tyrosine kinase inhibitors.
1. Cancer Res - published December 1, 2017
2. Terai H, Kitajima S, Potter DS, Matsui Y, Gutierrez Quiceno L, Chen T, Kim TJ, Rusan M, Thai TC, Piccioni F, Donovan KA, Kwiatkowski N, Hinohara K, Wei G, Gray NS, Fischer ES, Wong KK, Shimamura T, Letai A, Hammerman PS, Barbie DA
Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5.
1. Virology - published December 1, 2017
2. Schulte B, Selyutina A, Opp S, Herschhorn A, Sodroski JG, Pizzato M, Diaz-Griffero F
Generation of an induced pluripotent stem cell (iPSC) line from a 40-year-old patient with the A8344G mutation of mitochondrial DNA and MERRF (myoclonic epilepsy with ragged red fibers) syndrome.
1. Stem Cell Res - published December 1, 2017
2. Wu YT, Hsu YH, Huang CY, Ho MC, Cheng YC, Wen CH, Ko HW, Lu HE, Chen YC, Tsai CL, Hsu YC, Wei YH, Hsieh PCH
Inhibition of SDF-1-induced migration of oncogene-driven myeloid leukemia by the L-RNA aptamer (Spiegelmer), NOX-A12, and potentiation of tyrosine kinase inhibition.
1. Oncotarget - published December 1, 2017
2. Weisberg EL, Sattler M, Azab AK, Eulberg D, Kruschinski A, Manley PW, Stone R, Griffin JD
Mobile Web-Based Follow-up for Postoperative ACL Reconstruction: A Single-Center Experience.
1. Orthop J Sports Med - published December 1, 2017
2. Higgins J, Semple J, Murnaghan L, Sharpe S, Theodoropoulos J
Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study.
1. Chem Sci - published December 1, 2017
2. Sadaf A, Du Y, Santillan C, Mortensen JS, Molist I, Seven AB, Hariharan P, Skiniotis G, Loland CJ, Kobilka BK, Guan L, Byrne B, Chae PS