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126 Member Publications for November 2017

Rapid Prediction of Multi-dimensional NMR Data Sets Using FANDAS.
1. Methods Mol Biol - published November 20, 2017
2. Narasimhan S, Mance D, Pinto C, Weingarth M, Bonvin AMJJ, Baldus M
The PrpF protein of Shewanella oneidensis MR-1 catalyzes the isomerization of 2-methyl-cis-aconitate during the catabolism of propionate via the AcnD-dependent 2-methylcitric acid cycle.
1. PLoS One - published November 18, 2017
2. Rocco CJ, Wetterhorn KM, Garvey GS, Rayment I, Escalante-Semerena JC
Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection.
1. NPJ Biofilms Microbiomes - published November 15, 2017
2. Xu W, Flores-Mireles AL, Cusumano ZT, Takagi E, Hultgren SJ, Caparon MG
Coiled coils unspring protein origami.
1. Nat Biotechnol - published November 9, 2017
2. Hura GL, Tainer JA
Structural insight into TPX2-stimulated microtubule assembly.
1. Elife - published November 9, 2017
2. Zhang R, Roostalu J, Surrey T, Nogales E
Energy landscape differences among integrins establish the framework for understanding activation.
1. J Cell Biol - published November 9, 2017
2. Li J, Springer TA
Dominant-negative loss of function arises from a second, more frequent variant within the SAND domain of autoimmune regulator (AIRE).
1. J Autoimmun - published November 9, 2017
2. Abbott JK, Huoh YS, Reynolds PR, Yu L, Rewers M, Reddy M, Anderson MS, Hur S, Gelfand EW
Low-dose electron energy-loss spectroscopy using electron counting direct detectors.
1. Microscopy (Oxf) - published November 9, 2017
2. Maigné A, Wolf M
Enantioselective Total Synthesis of Antibiotic CJ-16,264, Synthesis and Biological Evaluation of Designed Analogues, and Discovery of Highly Potent and Simpler Antibacterial Agents.
1. J Am Chem Soc - published November 8, 2017
2. Nicolaou KC, Pulukuri KK, Rigol S, Buchman M, Shah AA, Cen N, McCurry MD, Beabout K, Shamoo Y
Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity.
1. Nat Commun - published November 8, 2017
2. Schnaider L, Brahmachari S, Schmidt NW, Mensa B, Shaham-Niv S, Bychenko D, Adler-Abramovich L, Shimon LJW, Kolusheva S, DeGrado WF, Gazit E
NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.
1. Cell Host Microbe - published November 8, 2017
2. Raaben M, Jae LT, Herbert AS, Kuehne AI, Stubbs SH, Chou YY, Blomen VA, Kirchhausen T, Dye JM, Brummelkamp TR, Whelan SP
Generation of an induced pluripotent stem cell line from a 39-year-old female patient with severe-to-profound non-syndromic sensorineural hearing loss and a A1555G mutation in the mitochondrial MTRNR1 gene.
1. Stem Cell Res - published November 8, 2017
2. Hsu YH, Wu YT, Huang CY, Ho MC, Cheng YC, Syu SH, Lu HE, Chen YC, Tsai CL, Lin HC, Wei YH, Hsu YC, Hsieh PCH
Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem.
1. Structure - published November 7, 2017
2. Delhommel F, Cordier F, Bardiaux B, Bouvier G, Colcombet-Cazenave B, Brier S, Raynal B, Nouaille S, Bahloul A, Chamot-Rooke J, Nilges M, Petit C, Wolff N
Alk and Ltk ligands are essential for iridophore development in zebrafish mediated by the receptor tyrosine kinase Ltk.
1. Proc Natl Acad Sci U S A - published November 7, 2017
2. Mo ES, Cheng Q, Reshetnyak AV, Schlessinger J, Nicoli S
Helicase SPRNTing through the nanopore.
1. Proc Natl Acad Sci U S A - published November 7, 2017
2. Caldwell CC, Spies M
Quantification of sensitivity and resistance of breast cancer cell lines to anti-cancer drugs using GR metrics.
1. Sci Data - published November 7, 2017
2. Hafner M, Heiser LM, Williams EH, Niepel M, Wang NJ, Korkola JE, Gray JW, Sorger PK
Deciphering Nature's Intricate Way of N,S-Dimethylating l-Cysteine: Sequential Action of Two Bifunctional Adenylation Domains.
1. Biochemistry - published November 7, 2017
2. Mori S, Garzan A, Tsodikov OV, Garneau-Tsodikova S
New free-exchange model of EmrE transport.
1. Proc Natl Acad Sci U S A - published November 7, 2017
2. Robinson AE, Thomas NE, Morrison EA, Balthazor BM, Henzler-Wildman KA
Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding.
1. J Biol Chem - published November 7, 2017
2. Glidden MD, Yang Y, Smith NA, Phillips NB, Carr K, Wickramasinghe NP, Ismail-Beigi F, Lawrence MC, Smith BJ, Weiss MA
The NOX Family of Proteins Is Also Present in Bacteria.
1. MBio - published November 7, 2017
2. Hajjar C, Cherrier MV, Dias Mirandela G, Petit-Hartlein I, Stasia MJ, Fontecilla-Camps JC, Fieschi F, Dupuy J
A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.
1. Cell Chem Biol - published November 7, 2017
2. Huang HT, Dobrovolsky D, Paulk J, Yang G, Weisberg EL, Doctor ZM, Buckley DL, Cho JH, Ko E, Jang J, Shi K, Choi HG, Griffin JD, Li Y, Treon SP, Fischer ES, Bradner JE, Tan L, Gray NS
The TRAPPIII complex activates the GTPase Ypt1 (Rab1) in the secretory pathway.
1. J Cell Biol - published November 6, 2017
2. Thomas LL, Joiner AMN, Fromme JC
Differences in combinations and concentrations of drugs of abuse in fatal intoxication and driving under the influence cases.
1. Forensic Sci Int - published November 6, 2017
2. Edvardsen HE, Tverborgvik T, Frost J, Rogde S, Morild I, Waal H, Clausen T, Slørdal L, Vindenes V
Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites.
1. Elife - published November 4, 2017
2. Sindikubwabo F, Ding S, Hussain T, Ortet P, Barakat M, Baumgarten S, Cannella D, Palencia A, Bougdour A, Belmudes L, Couté Y, Tardieux I, Botté CY, Scherf A, Hakimi MA
Marker-free method for accurate alignment between correlated light, cryo-light, and electron cryo-microscopy data using sample support features.
1. J Struct Biol - published November 4, 2017
2. Anderson KL, Page C, Swift MF, Hanein D, Volkmann N
Structural and Biochemical Investigation of PglF from Campylobacter jejuni Reveals a New Mechanism for a Member of the Short Chain Dehydrogenase/Reductase Superfamily.
1. Biochemistry - published November 3, 2017
2. Riegert AS, Thoden JB, Schoenhofen IC, Watson DC, Young NM, Tipton PA, Holden HM
CDK4/6 Inhibition Augments Anti-Tumor Immunity by Enhancing T Cell Activation.
1. Cancer Discov - published November 3, 2017
2. Deng J, Wang ES, Jenkins RW, Li S, Dries R, Yates K, Chhabra S, Huang W, Liu H, Aref AR, Ivanova E, Paweletz CP, Bowden M, Zhou CW, Herter-Sprie GS, Sorrentino JA, Bisi JE, Lizotte PH, Merlino AA, Quinn MM, Bufe LE, Yang A, Zhang Y, Zhang H, Gao P, Chen T, Cavanaugh ME, Rode AJ, Haines E, Roberts PJ, Strum JC, Richards WG, Lorch JH, Parangi S, Gunda V, Boland GM, Bueno R, Palakurthi S, Freeman GJ, Ritz J, Haining WN, Sharpless NE, Arthanari H, Shapiro GI, Barbie DA, Gray NS, Wong KK
Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2.
1. Nat Commun - published November 3, 2017
2. Schulze WM, Cusack S
NMR-Directed Design of PreTCRβ and pMHC Molecules Implies a Distinct Geometry for preTCR Relative to αβTCR Recognition of pMHC.
1. J Biol Chem - published November 3, 2017
2. Mallis RJ, Arthanari H, Lang MJ, Reinherz EL, Wagner G
The structural basis of proton driven zinc transport by ZntB.
1. Nat Commun - published November 3, 2017
2. Gati C, Stetsenko A, Slotboom DJ, Scheres SHW, Guskov A
A flexible loop for mannan recognition and activity enhancement in a bifunctional glycoside hydrolase family 5.
1. Biochim Biophys Acta - published November 3, 2017
2. Liang PH, Lin WL, Hsieh HY, Lin TY, Chen CH, Tewary SK, Lee HL, Yuan SF, Yang B, Yao JY, Ho MC
Matrix vesicles from chondrocytes and osteoblasts: Their biogenesis, properties, functions and biomimetic models.
1. Biochim Biophys Acta - published November 3, 2017
2. Bottini M, Mebarek S, Anderson KL, Strzelecka-Kiliszek A, Bozycki L, Simão AMS, Bolean M, Ciancaglini P, Pikula JB, Pikula S, Magne D, Volkmann N, Hanein D, Millán JL, Buchet R
Identification of a Functionally Unique Family of Penicillin-Binding Proteins.
1. J Am Chem Soc - published November 3, 2017
2. Welsh MA, Taguchi A, Schaefer K, Van Tyne D, Lebreton F, Gilmore MS, Kahne D, Walker S
Accessible virtual reality of biomolecular structural models using the Autodesk Molecule Viewer.
1. Nat Methods - published November 3, 2017
2. Balo AR, Wang M, Ernst OP
How Cryo-EM Became so Hot.
1. Cell - published November 3, 2017
2. Cheng Y, Glaeser RM, Nogales E
Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
1. Nucleic Acids Res - published November 3, 2017
2. Pflug A, Gaudon S, Resa-Infante P, Lethier M, Reich S, Schulze WM, Cusack S
Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10.
1. Cell - published November 3, 2017
2. Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC
Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2.
1. J Mol Biol - published November 2, 2017
2. Isaac RS, Sanulli S, Tibble R, Hornsby M, Ravalin M, Craik CS, Gross JD, Narlikar GJ
Activator Protein-1: redox switch controlling structure and DNA-binding.
1. Nucleic Acids Res - published November 2, 2017
2. Yin Z, Machius M, Nestler EJ, Rudenko G
Natively Unfolded FG Repeats Stabilize the Structure of the Nuclear Pore Complex.
1. Cell - published November 2, 2017
2. Onischenko E, Tang JH, Andersen KR, Knockenhauer KE, Vallotton P, Derrer CP, Kralt A, Mugler CF, Chan LY, Schwartz TU, Weis K
RNA editing with CRISPR-Cas13.
1. Science - published November 2, 2017
2. Cox DBT, Gootenberg JS, Abudayyeh OO, Franklin B, Kellner MJ, Joung J, Zhang F
Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions.
1. Front Mol Neurosci - published November 2, 2017
2. Ariazi J, Benowitz A, De Biasi V, Den Boer ML, Cherqui S, Cui H, Douillet N, Eugenin EA, Favre D, Goodman S, Gousset K, Hanein D, Israel DI, Kimura S, Kirkpatrick RB, Kuhn N, Jeong C, Lou E, Mailliard R, Maio S, Okafo G, Osswald M, Pasquier J, Polak R, Pradel G, de Rooij B, Schaeffer P, Skeberdis VA, Smith IF, Tanveer A, Volkmann N, Wu Z, Zurzolo C
Structure and function of yeast Atg20, a sorting nexin that facilitates autophagy induction.
1. Proc Natl Acad Sci U S A - published November 2, 2017
2. Popelka H, Damasio A, Hinshaw JE, Klionsky DJ, Ragusa MJ
Assigning chemoreceptors to chemosensory pathways in Pseudomonas aeruginosa.
1. Proc Natl Acad Sci U S A - published November 2, 2017
2. Ortega DR, Fleetwood AD, Krell T, Harwood CS, Jensen GJ, Zhulin IB
Calpain-5 gene expression in the mouse eye and brain.
1. BMC Res Notes - published November 2, 2017
2. Schaefer K, Mahajan M, Gore A, Tsang SH, Bassuk AG, Mahajan VB
Molecular basis for necitumumab inhibition of EGFR variants associated with acquired cetuximab resistance.
1. Mol Cancer Ther - published November 2, 2017
2. Bagchi A, Haidar JN, Eastman SW, Vieth M, Topper M, Iacolina MD, Walker JM, Forest A, Shen Y, Novosiadly RD, Ferguson KM
Single-molecule visualization of conformational changes and substrate transport in the vitamin B₁₂ ABC importer BtuCD-F.
1. Nat Commun - published November 2, 2017
2. Goudsmits JMH, Slotboom DJ, van Oijen AM
Focused conformational sampling in proteins.
1. J Chem Phys - published November 2, 2017
2. Bacci M, Langini C, Vymětal J, Caflisch A, Vitalis A
The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets.
1. Elife - published November 2, 2017
2. Han H, Monroe N, Sundquist WI, Shen PS, Hill CP
Crystal structure of the coxsackievirus A16 RNA-dependent RNA polymerase elongation complex reveals novel features in motif A dynamics.
1. Virol Sin - published November 2, 2017
2. Bi P, Shu B, Gong P
Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes.
1. Nat Commun - published November 2, 2017
2. Ait-Bouziad N, Lv G, Mahul-Mellier AL, Xiao S, Zorludemir G, Eliezer D, Walz T, Lashuel HA
The gating cycle of a K⁺ channel at atomic resolution.
1. Elife - published November 2, 2017
2. Cuello LG, Cortes DM, Perozo E
Molecular Structures of Yeast Kinetochore Subcomplexes and Their Roles in Chromosome Segregation.
1. Cold Spring Harb Symp Quant Biol - published November 2, 2017
2. Jenni S, Dimitrova YN, Valverde R, Hinshaw SM, Harrison SC
Viral Infection and Apoptosis.
1. Viruses - published November 2, 2017
2. Kvansakul M
Global substrate specificity profiling of post-translational modifying enzymes.
1. Protein Sci - published November 2, 2017
2. Ivry SL, Meyer NO, Winter MB, Bohn MF, Knudsen GM, O'Donoghue AJ, Craik CS
Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
1. Nat Commun - published November 2, 2017
2. Vincent J, Adura C, Gao P, Luz A, Lama L, Asano Y, Okamoto R, Imaeda T, Aida J, Rothamel K, Gogakos T, Steinberg J, Reasoner S, Aso K, Tuschl T, Patel DJ, Glickman JF, Ascano M
Gene Therapy Restores Mfrp and Corrects Axial Eye Length.
1. Sci Rep - published November 2, 2017
2. Velez G, Tsang SH, Tsai YT, Hsu CW, Gore A, Abdelhakim AH, Mahajan M, Silverman RH, Sparrow JR, Bassuk AG, Mahajan VB
Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs.
1. Nat Commun - published November 2, 2017
2. Partin AC, Ngo TD, Herrell E, Jeong BC, Hon G, Nam Y
Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors.
1. Nat Commun - published November 2, 2017
2. Tan J, Cognetta Iii AB, Diaz DB, Lum KM, Adachi S, Kundu S, Cravatt BF, Yudin AK
Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.
1. Nat Commun - published November 2, 2017
2. Williams WB, Zhang J, Jiang C, Nicely NI, Fera D, Luo K, Moody MA, Liao HX, Alam SM, Kepler TB, Ramesh A, Wiehe K, Holland JA, Bradley T, Vandergrift N, Saunders KO, Parks R, Foulger A, Xia SM, Bonsignori M, Montefiori DC, Louder M, Eaton A, Santra S, Scearce R, Sutherland L, Newman A, Bouton-Verville H, Bowman C, Bomze H, Gao F, Marshall DJ, Whitesides JF, Nie X, Kelsoe G, Reed SG, Fox CB, Clary K, Koutsoukos M, Franco D, Mascola JR, Harrison SC, Haynes BF, Verkoczy L
The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1.
1. Nat Commun - published November 2, 2017
2. Middleton AJ, Budhidarmo R, Das A, Zhu J, Foglizzo M, Mace PD, Day CL
From word models to executable models of signaling networks using automated assembly.
1. Mol Syst Biol - published November 2, 2017
2. Gyori BM, Bachman JA, Subramanian K, Muhlich JL, Galescu L, Sorger PK
Inhibition of Delta-induced Notch signaling using fucose analogs.
1. Nat Chem Biol - published November 2, 2017
2. Schneider M, Kumar V, Nordstrøm LU, Feng L, Takeuchi H, Hao H, Luca VC, Garcia KC, Stanley P, Wu P, Haltiwanger RS
Validation of Structures in the Protein Data Bank.
1. Structure - published November 2, 2017
2. Gore S, Sanz García E, Hendrickx PMS, Gutmanas A, Westbrook JD, Yang H, Feng Z, Baskaran K, Berrisford JM, Hudson BP, Ikegawa Y, Kobayashi N, Lawson CL, Mading S, Mak L, Mukhopadhyay A, Oldfield TJ, Patwardhan A, Peisach E, Sahni G, Sekharan MR, Sen S, Shao C, Smart OS, Ulrich EL, Yamashita R, Quesada M, Young JY, Nakamura H, Markley JL, Berman HM, Burley SK, Velankar S, Kleywegt GJ
Cohesin SA2 is a sequence independent DNA binding protein that recognizes DNA replication and repair intermediates.
1. J Biol Chem - published November 2, 2017
2. Countryman P, Fan Y, Gorthi A, Pan H, Strickland J, Kaur P, Wang X, Lin J, Lei X, White C, You C, Wirth N, Tessmer I, Pieler J, Riehn R, Bishop AJR, Tao YJ, Wang H
Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity.
1. Sci Rep - published November 2, 2017
2. Hansen S, Stüber JC, Ernst P, Koch A, Bojar D, Batyuk A, Plückthun A
Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency.
1. Nat Biotechnol - published November 2, 2017
2. Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, Ernst A, Ng TF, Cho T, Cannon PM, Sidhu SS, Sicheri F, Durocher D
A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core.
1. J Biol Chem - published November 2, 2017
2. O'Donnell JP, Byrnes LJ, Cooley RB, Sondermann H
The crystal structure of Deg9 reveals a novel octameric-type HtrA protease.
1. Nat Plants - published November 2, 2017
2. Ouyang M, Li X, Zhao S, Pu H, Shen J, Adam Z, Clausen T, Zhang L
Structural Investigation of a Dimeric Variant of Pyruvate Kinase M2.
1. Biochemistry - published November 2, 2017
2. Srivastava D, Razzaghi M, Henzl MT, Dey M
Immunoproteasome functions explained by divergence in cleavage specificity and regulation.
1. Elife - published November 2, 2017
2. Winter MB, La Greca F, Arastu-Kapur S, Caiazza F, Cimermancic P, Buchholz TJ, Anderl JL, Ravalin M, Bohn MF, Sali A, O'Donoghue AJ, Craik CS
Consensus queries in ligand-based virtual screening experiments.
1. J Cheminform - published November 2, 2017
2. Berenger F, Vu O, Meiler J
Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2.
1. Elife - published November 2, 2017
2. Long Y, Bolanos B, Gong L, Liu W, Goodrich KJ, Yang X, Chen S, Gooding AR, Maegley KA, Gajiwala KS, Brooun A, Cech TR, Liu X
Capturing endosomal vesicles at the Golgi.
1. Nat Cell Biol - published November 2, 2017
2. Fromme JC, Munson M
The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.
1. Cell Syst - published November 2, 2017
2. Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, Wang Z, Dohlman AB, Silverstein MC, Lachmann A, Kuleshov MV, Ma'ayan A, Stathias V, Terryn R, Cooper D, Forlin M, Koleti A, Vidovic D, Chung C, Schürer SC, Vasiliauskas J, Pilarczyk M, Shamsaei B, Fazel M, Ren Y, Niu W, Clark NA, White S, Mahi N, Zhang L, Kouril M, Reichard JF, Sivaganesan S, Medvedovic M, Meller J, Koch RJ, Birtwistle MR, Iyengar R, Sobie EA, Azeloglu EU, Kaye J, Osterloh J, Haston K, Kalra J, Finkbiener S, Li J, Milani P, Adam M, Escalante-Chong R, Sachs K, Lenail A, Ramamoorthy D, Fraenkel E, Daigle G, Hussain U, Coye A, Rothstein J, Sareen D, Ornelas L, Banuelos M, Mandefro B, Ho R, Svendsen CN, Lim RG, Stocksdale J, Casale MS, Thompson TG, Wu J, Thompson LM, Dardov V, Venkatraman V, Matlock A, Van Eyk JE, Jaffe JD, Papanastasiou M, Subramanian A, Golub TR, Erickson SD, Fallahi-Sichani M, Hafner M, Gray NS, Lin JR, Mills CE, Muhlich JL, Niepel M, Shamu CE, Williams EH, Wrobel D, Sorger PK, Heiser LM, Gray JW, Korkola JE, Mills GB, LaBarge M, Feiler HS, Dane MA, Bucher E, Nederlof M, Sudar D, Gross S, Kilburn DF, Smith R, Devlin K, Margolis R, Derr L, Lee A, Pillai A
Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family.
1. Cell Chem Biol - published November 2, 2017
2. Reidenbach AG, Kemmerer ZA, Aydin D, Jochem A, McDevitt MT, Hutchins PD, Stark JL, Stefely JA, Reddy T, Hebert AS, Wilkerson EM, Johnson IE, Bingman CA, Markley JL, Coon JJ, Dal Peraro M, Pagliarini DJ
Using PyMOL to Explore the Effects of pH on Noncovalent Interactions between Immunoglobulin G and Protein A: A Guided-Inquiry Biochemistry Activity.
1. Biochem Mol Biol Educ - published November 1, 2017
2. Roche Allred ZD, Tai H, Bretz SL, Page RC
Regulation of E2s: A Role for Additional Ubiquitin Binding Sites?
1. J Mol Biol - published November 1, 2017
2. Middleton AJ, Wright JD, Day CL
LytM factors affect the recruitment of autolysins to the cell division site in Caulobacter crescentus.
1. Mol Microbiol - published November 1, 2017
2. Zielińska A, Billini M, Möll A, Kremer K, Briegel A, Izquierdo Martinez A, Jensen GJ, Thanbichler M
Structural analysis of the interaction between Jaburetox, an intrinsically disordered protein, and membrane models.
1. Colloids Surf B Biointerfaces - published November 1, 2017
2. Broll V, Martinelli AHS, Lopes FC, Fruttero LL, Zambelli B, Salladini E, Dobrovolska O, Ciurli S, Carlini CR
Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma.
1. Am J Surg Pathol - published November 1, 2017
2. Sajed DP, Faquin WC, Carey C, Severson EA, H Afrogheh A, A Johnson C, Blacklow SC, Chau NG, Lin DT, Krane JF, Jo VY, Garcia JJ, Sholl LM, Aster JC
Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs.
1. J Biol Chem - published November 1, 2017
2. Lin Y, Currie SL, Rosen MK
Controlling Styrene Maleic Acid Lipid Particles through RAFT.
1. Biomacromolecules - published November 1, 2017
2. Smith AAA, Autzen HE, Laursen T, Wu V, Yen M, Hall A, Hansen SD, Cheng Y, Xu T
The complete structure of the small-subunit processome.
1. Nat Struct Mol Biol - published November 1, 2017
2. Barandun J, Chaker-Margot M, Hunziker M, Molloy KR, Chait BT, Klinge S
A homodimer interface without base pairs in an RNA mimic of red fluorescent protein.
1. Nat Chem Biol - published November 1, 2017
2. Warner KD, Sjekloća L, Song W, Filonov GS, Jaffrey SR, Ferré-D'Amaré AR
Experimental Evolution of Diverse Strains as a Method for the Determination of Biochemical Mechanisms of Action for Novel Pyrrolizidinone Antibiotics.
1. ACS Infect Dis - published November 1, 2017
2. Beabout K, McCurry MD, Mehta H, Shah AA, Pulukuri KK, Rigol S, Wang Y, Nicolaou KC, Shamoo Y
Utilizing tagged paramagnetic shift reagents to monitor protein dynamics by NMR.
1. Biochim Biophys Acta - published November 1, 2017
2. Ye L, Van Eps N, Li X, Ernst OP, Prosser RS
New perspectives for targeting RAF kinase in human cancer.
1. Nat Rev Cancer - published November 1, 2017
2. Karoulia Z, Gavathiotis E, Poulikakos PI
Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development.
1. Development - published November 1, 2017
2. Mathew S, Palamuttam RJ, Mernaugh G, Ramalingam H, Lu Z, Zhang MZ, Ishibe S, Critchley DR, Fässler R, Pozzi A, Sanders CR, Carroll TJ, Zent R
Modulation of proteolytic polyprotein processing by coxsackievirus mutants resistant to inhibitors targeting phosphatidylinositol-4-kinase IIIβ or oxysterol binding protein.
1. Antiviral Res - published November 1, 2017
2. Lyoo H, Dorobantu CM, van der Schaar HM, van Kuppeveld FJM
The SMAD3 transcription factor binds complex RNA structures with high affinity.
1. Nucleic Acids Res - published November 1, 2017
2. Dickey TH, Pyle AM
The role of toxins in Clostridium difficile infection.
1. FEMS Microbiol Rev - published November 1, 2017
2. Chandrasekaran R, Lacy DB
Channel surfing uncovers a dual-use transporter.
1. EMBO J - published November 1, 2017
2. Minor DL Jr
Metabolism of megestrol acetate in vitro and the role of oxidative metabolites.
1. Xenobiotica - published November 1, 2017
2. House L, Seminerio MJ, Mirkov S, Ramirez J, Skor M, Sachleben JR, Isikbay M, Singhal H, Greene GL, Vander Griend D, Conzen SD, Ratain MJ
Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins.
1. Elife - published November 1, 2017
2. Harmon TS, Holehouse AS, Rosen MK, Pappu RV
Expression and Purification of Protein Complexes Suitable for Structural Studies Using Mammalian HEK 293F Cells.
1. Curr Protoc Protein Sci - published November 1, 2017
2. Nigi I, Fairall L, Schwabe JWR
Screening and Identifying Membrane Proteins Favorable for Crystallization.
1. Curr Protoc Protein Sci - published November 1, 2017
2. Kim J, Ng HL
Interaction between the flagellar pocket collar and the hook complex via a novel microtubule-binding protein in Trypanosoma brucei.
1. PLoS Pathog - published November 1, 2017
2. Albisetti A, Florimond C, Landrein N, Vidilaseris K, Eggenspieler M, Lesigang J, Dong G, Robinson DR, Bonhivers M
Structural dissection of human metapneumovirus phosphoprotein using small angle x-ray scattering.
1. Sci Rep - published November 1, 2017
2. Renner M, Paesen GC, Grison CM, Granier S, Grimes JM, Leyrat C
A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit.
1. ACS Chem Biol - published November 1, 2017
2. Skiba MA, Sikkema AP, Moss NA, Tran CL, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL
Imaging PD-L1 Expression with ImmunoPET.
1. Bioconjug Chem - published November 1, 2017
2. Truillet C, Oh HLJ, Yeo SP, Lee CY, Huynh LT, Wei J, Parker MFL, Blakely C, Sevillano N, Wang YH, Shen YS, Olivas V, Jami KM, Moroz A, Jego B, Jaumain E, Fong L, Craik CS, Chang AJ, Bivona TG, Wang CI, Evans MJ
Structural basis of arrestin-3 activation and signaling.
1. Nat Commun - published November 1, 2017
2. Chen Q, Perry NA, Vishnivetskiy SA, Berndt S, Gilbert NC, Zhuo Y, Singh PK, Tholen J, Ohi MD, Gurevich EV, Brautigam CA, Klug CS, Gurevich VV, Iverson TM
A thermostable Cas9 with increased lifetime in human plasma.
1. Nat Commun - published November 1, 2017
2. Harrington LB, Paez-Espino D, Staahl BT, Chen JS, Ma E, Kyrpides NC, Doudna JA
Ubiquitin turnover and endocytic trafficking in yeast are regulated by Ser57 phosphorylation of ubiquitin.
1. Elife - published November 1, 2017
2. Lee S, Tumolo JM, Ehlinger AC, Jernigan KK, Qualls-Histed SJ, Hsu PC, McDonald WH, Chazin WJ, MacGurn JA
Ist1 regulates ESCRT-III assembly and function during multivesicular endosome biogenesis in Caenorhabditis elegans embryos.
1. Nat Commun - published November 1, 2017
2. Frankel EB, Shankar R, Moresco JJ, Yates JR 3rd, Volkmann N, Audhya A
The role of calprotectin in withholding zinc and copper from <i>Candida albicans</i>.
1. Infect Immun - published November 1, 2017
2. Besold AN, Gilston BA, Radin JN, Ramsoomair C, Culbertson EM, Li CX, Cormack BP, Chazin WJ, Kehl-Fie TE, Culotta VC
Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers.
1. Nat Commun - published November 1, 2017
2. Sivaramakrishnan M, McCarthy KD, Campagne S, Huber S, Meier S, Augustin A, Heckel T, Meistermann H, Hug MN, Birrer P, Moursy A, Khawaja S, Schmucki R, Berntenis N, Giroud N, Golling S, Tzouros M, Banfai B, Duran-Pacheco G, Lamerz J, Hsiu Liu Y, Luebbers T, Ratni H, Ebeling M, Cléry A, Paushkin S, Krainer AR, Allain FH, Metzger F
Partner switching for Ran during the mitosis dance.
1. J Mol Cell Biol - published November 1, 2017
2. Yang Y, Yu H
Host Methyltransferases and Demethylases: Potential New Epigenetic Targets for HIV Cure Strategies and Beyond.
1. AIDS Res Hum Retroviruses - published November 1, 2017
2. Boehm D, Ott M
Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc.
1. Nat Commun - published November 1, 2017
2. Su MY, Som N, Wu CY, Su SC, Kuo YT, Ke LC, Ho MR, Tzeng SR, Teng CH, Mengin-Lecreulx D, Reddy M, Chang CI
Widespread Translational Remodeling during Human Neuronal Differentiation.
1. Cell Rep - published November 1, 2017
2. Blair JD, Hockemeyer D, Doudna JA, Bateup HS, Floor SN
MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia.
1. Sci Signal - published November 1, 2017
2. Pajcini KV, Xu L, Shao L, Petrovic J, Palasiewicz K, Ohtani Y, Bailis W, Lee C, Wertheim GB, Mani R, Musuthamy N, Li Y, Meijerink JPP, Blacklow SC, Faryabi RB, Cherry S, Pear WS
A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.
1. Nature - published November 1, 2017
2. Brickner JR, Soll JM, Lombardi PM, Vågbø CB, Mudge MC, Oyeniran C, Rabe R, Jackson J, Sullender ME, Blazosky E, Byrum AK, Zhao Y, Corbett MA, Gécz J, Field M, Vindigni A, Slupphaug G, Wolberger C, Mosammaparast N
Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5.
1. Nat Commun - published November 1, 2017
2. Bärlocher K, Hutter CAJ, Swart AL, Steiner B, Welin A, Hohl M, Letourneur F, Seeger MA, Hilbi H
Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria.
1. Mol Cell - published November 1, 2017
2. Nielson JR, Fredrickson EK, Waller TC, Rendón OZ, Schubert HL, Lin Z, Hill CP, Rutter J
Anti-Inflammatory and Antinociceptive Effects of Ethyl Acetate Fraction of an Edible Red Macroalgae Sarcodia ceylanica.
1. Int J Mol Sci - published November 1, 2017
2. Shih CC, Hwang HR, Chang CI, Su HM, Chen PC, Kuo HM, Li PJ, Wang HD, Tsui KH, Lin YC, Huang SY, Wen ZH
Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
1. Mol Cell - published November 1, 2017
2. Brouwer JM, Lan P, Cowan AD, Bernardini JP, Birkinshaw RW, van Delft MF, Sleebs BE, Robin AY, Wardak A, Tan IK, Reljic B, Lee EF, Fairlie WD, Call MJ, Smith BJ, Dewson G, Lessene G, Colman PM, Czabotar PE
Protein structure-based drug design: from docking to molecular dynamics.
1. Curr Opin Struct Biol - published November 1, 2017
2. Śledź P, Caflisch A
The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion.
1. Science - published November 1, 2017
2. Tenthorey JL, Haloupek N, López-Blanco JR, Grob P, Adamson E, Hartenian E, Lind NA, Bourgeois NM, Chacón P, Nogales E, Vance RE
Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.
1. Nat Commun - published November 1, 2017
2. Scally SW, McLeod B, Bosch A, Miura K, Liang Q, Carroll S, Reponen S, Nguyen N, Giladi E, Rämisch S, Yusibov V, Bradley A, Lemiale F, Schief WR, Emerling D, Kellam P, King CR, Julien JP
Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
1. Nat Commun - published November 1, 2017
2. Shalev-Benami M, Zhang Y, Rozenberg H, Nobe Y, Taoka M, Matzov D, Zimmerman E, Bashan A, Isobe T, Jaffe CL, Yonath A, Skiniotis G
Correlative Super-resolution and Electron Microscopy to Resolve Protein Localization in Zebrafish Retina.
1. J Vis Exp - published November 1, 2017
2. Mateos JM, Barmettler G, Doehner J, Ojeda Naharros I, Guhl B, Neuhauss SCF, Kaech A, Bachmann-Gagescu R, Ziegler U
Dissection of Human Retina and RPE-Choroid for Proteomic Analysis.
1. J Vis Exp - published November 1, 2017
2. Cabral T, Toral MA, Velez G, DiCarlo JE, Gore AM, Mahajan M, Tsang SH, Bassuk AG, Mahajan VB
New crystal forms of the integral membrane Escherichia coli quinol:fumarate reductase suggest that ligands control domain movement.
1. J Struct Biol - published November 1, 2017
2. Starbird CA, Tomasiak TM, Singh PK, Yankovskaya V, Maklashina E, Eisenbach M, Cecchini G, Iverson TM
Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis.
1. JCI Insight - published November 1, 2017
2. Patten SA, Aggad D, Martinez J, Tremblay E, Petrillo J, Armstrong GA, La Fontaine A, Maios C, Liao M, Ciura S, Wen XY, Rafuse V, Ichida J, Zinman L, Julien JP, Kabashi E, Robitaille R, Korngut L, Parker JA, Drapeau P
Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR-Cas9 genome editing.
1. Nat Biomed Eng - published November 1, 2017
2. Paulsen BS, Mandal PK, Frock RL, Boyraz B, Yadav R, Upadhyayula S, Gutierrez-Martinez P, Ebina W, Fasth A, Kirchhausen T, Talkowski ME, Agarwal S, Alt FW, Rossi DJ