Member Publications

Jump to specific year:

139 Member Publications for October 2017

Adjuvants and the vaccine response to the DS-Cav1-stabilized fusion glycoprotein of respiratory syncytial virus.
1. PLoS One - published October 27, 2017
2. Sastry M, Zhang B, Chen M, Joyce MG, Kong WP, Chuang GY, Ko K, Kumar A, Silacci C, Thom M, Salazar AM, Corti D, Lanzavecchia A, Taylor G, Mascola JR, Graham BS, Kwong PD
Stopped-Flow Fluorometric Ion Flux Assay for Ligand-Gated Ion Channel Studies.
1. Methods Mol Biol - published October 24, 2017
2. Posson DJ, Rusinova R, Andersen OS, Nimigean CM
Studying Mechanosensitivity of Two-Pore Domain K+ Channels in Cellular and Reconstituted Proteoliposome Membranes.
1. Methods Mol Biol - published October 24, 2017
2. Del Mármol J, Rietmeijer RA, Brohawn SG
The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia.
1. PLoS One - published October 13, 2017
2. Choi SH, Severson E, Pear WS, Liu XS, Aster JC, Blacklow SC
A Simple PB/LIE Free Energy Function Accurately Predicts the Peptide Binding Specificity of the Tiam1 PDZ Domain.
1. Front Mol Biosci - published October 12, 2017
2. Panel N, Sun YJ, Fuentes EJ, Simonson T
Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling.
1. Nat Commun - published October 9, 2017
2. Ren X, Gelinas AD, von Carlowitz I, Janjic N, Pyle AM
Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.
1. Cancer Cell - published October 9, 2017
2. Reyna DE, Garner TP, Lopez A, Kopp F, Choudhary GS, Sridharan A, Narayanagari SR, Mitchell K, Dong B, Bartholdy BA, Walensky LD, Verma A, Steidl U, Gavathiotis E
PAK4 crystal structures suggest unusual kinase conformational movements.
1. Biochim Biophys Acta - published October 7, 2017
2. Zhang EY, Ha BH, Boggon TJ
Applications of sequence coevolution in membrane protein biochemistry.
1. Biochim Biophys Acta - published October 7, 2017
2. Nicoludis JM, Gaudet R
Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) expression tracks with M2-like macrophage activity and disease severity in COPD.
1. Chest - published October 7, 2017
2. Byers DE, Wu K, Dang-Vu G, Jin X, Agapov E, Zhang X, Battaile JT, Schechtman K, Yusen R, Pierce RA, Holtzman MJ
Sending and Receiving Hedgehog Signals.
1. Annu Rev Cell Dev Biol - published October 6, 2017
2. Petrov K, Wierbowski BM, Salic A
Cell-cell adhesion in metazoans relies on evolutionarily conserved features of the α-catenin·β-catenin-binding interface.
1. J Biol Chem - published October 6, 2017
2. Shao X, Kang H, Loveless T, Lee GR, Seok C, Weis WI, Choi HJ, Hardin J
Mitotic transcription and waves of gene reactivation during mitotic exit.
1. Science - published October 6, 2017
2. Palozola KC, Donahue G, Liu H, Grant GR, Becker JS, Cote A, Yu H, Raj A, Zaret KS
Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques.
1. Science - published October 6, 2017
2. Xu L, Pegu A, Rao E, Doria-Rose N, Beninga J, McKee K, Lord DM, Wei RR, Deng G, Louder M, Schmidt SD, Mankoff Z, Wu L, Asokan M, Beil C, Lange C, Leuschner WD, Kruip J, Sendak R, Kwon YD, Zhou T, Chen X, Bailer RT, Wang K, Choe M, Tartaglia LJ, Barouch DH, O'Dell S, Todd JP, Burton DR, Roederer M, Connors M, Koup RA, Kwong PD, Yang ZY, Mascola JR, Nabel GJ
Ligand modulation of sidechain dynamics in a wild-type human GPCR.
1. Elife - published October 6, 2017
2. Clark LD, Dikiy I, Chapman K, Rödström KE, Aramini J, LeVine MV, Khelashvili G, Rasmussen SG, Gardner KH, Rosenbaum DM
Orthogonal Tyrosine and Cysteine Site-Directed Spin Labeling for Dipolar Pulse EPR Spectroscopy on Proteins.
1. J Phys Chem Lett - published October 5, 2017
2. Gmeiner C, Klose D, Mileo E, Belle V, Marque SRA, Dorn G, Allain FHT, Guigliarelli B, Jeschke G, Yulikov M
The Arf-GAP and Protein Scaffold Cat1/Git1 as a Multifaceted Regulator of Cancer Progression.
1. Small GTPases - published October 5, 2017
2. Yoo SM, Cerione RA, Antonyak MA
Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex.
1. Cell - published October 5, 2017
2. Guo TW, Bartesaghi A, Yang H, Falconieri V, Rao P, Merk A, Eng ET, Raczkowski AM, Fox T, Earl LA, Patel DJ, Subramaniam S
Defining the interaction of the protease CpaA with its type II secretion-chaperone CpaB and its contribution to virulence in Acinetobacter species.
1. J Biol Chem - published October 5, 2017
2. Kinsella RL, Lopez J, Palmer LD, Salinas ND, Skaar EP, Tolia NH, Feldman MF
Protein Expression and Purification of the Hsp90-Cdc37-Cdk4 Kinase Complex from Saccharomyces cerevisiae.
1. Bio Protoc - published October 5, 2017
2. Verba KA, Agard DA
Regulation of Arf activation occurs via distinct mechanisms at early and late Golgi compartments.
1. Mol Biol Cell - published October 4, 2017
2. Gustafson MA, Fromme JC
Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts.
1. Structure - published October 3, 2017
2. Joseph RE, Wales TE, Fulton DB, Engen JR, Andreotti AH
Microsecond Dynamics and Network Analysis of the HIV-1 SOSIP Env Trimer Reveal Collective Behavior and Conserved Microdomains of the Glycan Shield.
1. Structure - published October 3, 2017
2. Lemmin T, Soto C, Stuckey J, Kwong PD
Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein.
1. Proc Natl Acad Sci U S A - published October 3, 2017
2. Li W, Hulswit RJG, Widjaja I, Raj VS, McBride R, Peng W, Widagdo W, Tortorici MA, van Dieren B, Lang Y, van Lent JWM, Paulson JC, de Haan CAM, de Groot RJ, van Kuppeveld FJM, Haagmans BL, Bosch BJ
An unfolded protein-induced conformational switch activates mammalian IRE1.
1. Elife - published October 3, 2017
2. Karagöz GE, Acosta-Alvear D, Nguyen HT, Lee CP, Chu F, Walter P
Scipion web tools: Easy to use Cryo-EM image processing over the web.
1. Protein Sci - published October 3, 2017
2. Conesa Mingo P, Gutierrez J, Quintana A, de la Rosa Trevín JM, Zaldívar-Peraza A, Cuenca Alba J, Kazemi M, Vargas J, Del Cano L, Segura J, S Sorzano CO, Carazo JM
Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation.
1. Nat Commun - published October 3, 2017
2. Wong JJW, Young TA, Zhang J, Liu S, Leser GP, Komives EA, Lamb RA, Zhou ZH, Salafsky J, Jardetzky TS
Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
1. Eur Biophys J - published October 3, 2017
2. Mickevičiūtė A, Timm DD, Gedgaudas M, Linkuvienė V, Chen Z, Waheed A, Michailovienė V, Zubrienė A, Smirnov A, Čapkauskaitė E, Baranauskienė L, Jachno J, Revuckienė J, Manakova E, Gražulis S, Matulienė J, Di Cera E, Sly WS, Matulis D
Switching on BTK-One Domain at a Time.
1. Structure - published October 3, 2017
2. Agnew C, Jura N
MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation.
1. Cell Metab - published October 3, 2017
2. Lee KM, Giltnane JM, Balko JM, Schwarz LJ, Guerrero-Zotano AL, Hutchinson KE, Nixon MJ, Estrada MV, Sánchez V, Sanders ME, Lee T, Gómez H, Lluch A, Pérez-Fidalgo JA, Wolf MM, Andrejeva G, Rathmell JC, Fesik SW, Arteaga CL
Bacillus anthracis Prolyl 4-Hydroxylase Interacts with and Modifies Elongation Factor Tu.
1. Biochemistry - published October 3, 2017
2. Schnicker NJ, Razzaghi M, Guha Thakurta S, Chakravarthy S, Dey M
Kinetochore Function from the Bottom Up.
1. Trends Cell Biol - published October 3, 2017
2. Hinshaw SM, Harrison SC
In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase.
1. Proc Natl Acad Sci U S A - published October 3, 2017
2. Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale RD
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions.
1. Proc Natl Acad Sci U S A - published October 3, 2017
2. Swaminathan V, Kalappurakkal JM, Mehta SB, Nordenfelt P, Moore TI, Koga N, Baker DA, Oldenbourg R, Tani T, Mayor S, Springer TA, Waterman CM
Trigger loop dynamics can explain stimulation of intrinsic termination by bacterial RNA polymerase without terminator hairpin contact.
1. Proc Natl Acad Sci U S A - published October 3, 2017
2. Ray-Soni A, Mooney RA, Landick R
CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy.
1. Proc Natl Acad Sci U S A - published October 3, 2017
2. Ma L, Boucher JI, Paulsen J, Matuszewski S, Eide CA, Ou J, Eickelberg G, Press RD, Zhu LJ, Druker BJ, Branford S, Wolfe SA, Jensen JD, Schiffer CA, Green MR, Bolon DN
Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme.
1. Nat Commun - published October 3, 2017
2. Zheng L, Mairhofer E, Teplova M, Zhang Y, Ma J, Patel DJ, Micura R, Ren A
Pharmacological inhibition of the transcription factor PU.1 in leukemia.
1. J Clin Invest - published October 3, 2017
2. Antony-Debré I, Paul A, Leite J, Mitchell K, Kim HM, Carvajal LA, Todorova TI, Huang K, Kumar A, Farahat AA, Bartholdy B, Narayanagari SR, Chen J, Ambesi-Impiombato A, Ferrando AA, Mantzaris I, Gavathiotis E, Verma A, Will B, Boykin DW, Wilson WD, Poon GM, Steidl U
PatB1 is an O-acetyltransferase that decorates secondary cell wall polysaccharides.
1. Nat Chem Biol - published October 3, 2017
2. Sychantha D, Little DJ, Chapman RN, Boons GJ, Robinson H, Howell PL, Clarke AJ
Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX.
1. Nat Commun - published October 3, 2017
2. Hoelper D, Huang H, Jain AY, Patel DJ, Lewis PW
Protocadherin cis-dimer architecture and recognition unit diversity.
1. Proc Natl Acad Sci U S A - published October 3, 2017
2. Goodman KM, Rubinstein R, Dan H, Bahna F, Mannepalli S, Ahlsén G, Aye Thu C, Sampogna RV, Maniatis T, Honig B, Shapiro L
Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling.
1. Nat Commun - published October 3, 2017
2. Niepel M, Hafner M, Duan Q, Wang Z, Paull EO, Chung M, Lu X, Stuart JM, Golub TR, Subramanian A, Ma'ayan A, Sorger PK
Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway.
1. Cell Rep - published October 3, 2017
2. Kato N, Kawasoe Y, Williams H, Coates E, Roy U, Shi Y, Beese LS, Schärer OD, Yan H, Gottesman ME, Takahashi TS, Gautier J
MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.
1. Sci Signal - published October 3, 2017
2. Sandí MJ, Marshall CB, Balan M, Coyaud É, Zhou M, Monson DM, Ishiyama N, Chandrakumar AA, La Rose J, Couzens AL, Gingras AC, Raught B, Xu W, Ikura M, Morrison DK, Rottapel R
Membrane dynamics and organelle biogenesis-lipid pipelines and vesicular carriers.
1. BMC Biol - published October 3, 2017
2. Stefan CJ, Trimble WS, Grinstein S, Drin G, Reinisch K, De Camilli P, Cohen S, Valm AM, Lippincott-Schwartz J, Levine TP, Iaea DB, Maxfield FR, Futter CE, Eden ER, Judith D, van Vliet AR, Agostinis P, Tooze SA, Sugiura A, McBride HM
Complex regulatory mechanisms mediated by the interplay of multiple post-translational modifications.
1. Curr Opin Struct Biol - published October 3, 2017
2. Csizmok V, Forman-Kay JD
Big data in cryoEM: automated collection, processing and accessibility of EM data.
1. Curr Opin Microbiol - published October 3, 2017
2. Baldwin PR, Tan YZ, Eng ET, Rice WJ, Noble AJ, Negro CJ, Cianfrocco MA, Potter CS, Carragher B
Generation of induced pluripotent stem cells from a patient with Parkinson's disease carrying LRRK2 p.I2012T mutation.
1. Stem Cell Res - published October 3, 2017
2. Lin CH, Cheng YC, Lin HI, Ho MC, Hsu YH, Wen CH, Ko HW, Lu HE, Huang CY, Hsieh PCH
Discovery of Inhibitors of Four Bromodomains by Fragment-Anchored Ligand Docking.
1. J Chem Inf Model - published October 2, 2017
2. Marchand JR, Dalle Vedove A, Lolli G, Caflisch A
Switch I-dependent allosteric signaling in a G-protein chaperone-B12 enzyme complex.
1. J Biol Chem - published October 2, 2017
2. Campanello GC, Lofgren M, Yokom AL, Southworth DR, Banerjee R
The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain.
1. J Biol Chem - published October 2, 2017
2. Xu Z, Gakhar L, Bain FE, Spies M, Fuentes EJ
A novel mechanism for Ca²⁺/calmodulin-dependent protein kinase II targeting to L-type Ca²⁺ channels that initiates long-range signaling to the nucleus.
1. J Biol Chem - published October 2, 2017
2. Wang X, Marks CR, Perfitt TL, Nakagawa T, Lee A, Jacobson DA, Colbran RJ
Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane.
1. Proc Natl Acad Sci U S A - published October 2, 2017
2. Karandur D, Nawrotek A, Kuriyan J, Cherfils J
Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine.
1. ChemMedChem - published October 2, 2017
2. Monjas L, Swier LJYM, Setyawati I, Slotboom DJ, Hirsch AKH
Structural Basis for G Protein-Coupled Receptor Activation.
1. Biochemistry - published October 2, 2017
2. Manglik A, Kruse AC
Inhibition of USP10 induces degradation of oncogenic FLT3.
1. Nat Chem Biol - published October 2, 2017
2. Weisberg EL, Schauer NJ, Yang J, Lamberto I, Doherty L, Bhatt S, Nonami A, Meng C, Letai A, Wright R, Tiv H, Gokhale PC, Ritorto MS, De Cesare V, Trost M, Christodoulou A, Christie A, Weinstock DM, Adamia S, Stone R, Chauhan D, Anderson KC, Seo HS, Dhe-Paganon S, Sattler M, Gray NS, Griffin JD, Buhrlage SJ
Molecular basis of human CD22 function and therapeutic targeting.
1. Nat Commun - published October 2, 2017
2. Ereño-Orbea J, Sicard T, Cui H, Mazhab-Jafari MT, Benlekbir S, Guarné A, Rubinstein JL, Julien JP
Biosynthesis of Nucleoside Diphosphoramidates in Campylobacter jejuni.
1. Biochemistry - published October 2, 2017
2. Taylor ZW, Brown HA, Holden HM, Raushel FM
Spin labelling for integrative structure modelling: a case study of the polypyrimidine-tract binding protein 1 domains in complexes with short RNAs.
1. Phys Chem Chem Phys - published October 2, 2017
2. Gmeiner C, Dorn G, Allain FHT, Jeschke G, Yulikov M
Structural and Functional Insight into Canarypox Virus CNP058 Mediated Regulation of Apoptosis.
1. Viruses - published October 2, 2017
2. Anasir MI, Baxter AA, Poon IKH, Hulett MD, Kvansakul M
Allosteric control of a bacterial stress response system by an anti-σ factor.
1. Mol Microbiol - published October 2, 2017
2. Luebke JL, Eaton DS, Sachleben JR, Crosson S
Selective base excision repair of DNA damage by the non-base-flipping DNA glycosylase AlkC.
1. EMBO J - published October 2, 2017
2. Shi R, Mullins EA, Shen XX, Lay KT, Yuen PK, David SS, Rokas A, Eichman BF
Combining short- and long-range fluorescence reporters with simulations to explore the intramolecular dynamics of an intrinsically disordered protein.
1. J Chem Phys - published October 2, 2017
2. Zosel F, Haenni D, Soranno A, Nettels D, Schuler B
Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity.
1. Nat Commun - published October 2, 2017
2. Lim CJ, Zaug AJ, Kim HJ, Cech TR
COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal.
1. Elife - published October 2, 2017
2. Xu P, Hankins HM, MacDonald C, Erlinger SJ, Frazier MN, Diab NS, Piper RC, Jackson LP, MacGurn JA, Graham TR
An engineered vaccine of the Plasmodium vivax Duffy binding protein enhances induction of broadly neutralizing antibodies.
1. Sci Rep - published October 2, 2017
2. Ntumngia FB, Pires CV, Barnes SJ, George MT, Thomson-Luque R, Kano FS, Alves JRS, Urusova D, Pereira DB, Tolia NH, King CL, Carvalho LH, Adams JH
What's in a name?
1. Elife - published October 2, 2017
2. Schaller MD, McDowell G, Porter A, Shippen D, Friedman KL, Gentry MS, Serio TR, Sundquist WI
Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.
1. Nat Commun - published October 2, 2017
2. Smith MJ, Ottoni E, Ishiyama N, Goudreault M, Haman A, Meyer C, Tucholska M, Gasmi-Seabrook G, Menezes S, Laister RC, Minden MD, Marschalek R, Gingras AC, Hoang T, Ikura M
Scaffolding the cup-shaped double membrane in autophagy.
1. PLoS Comput Biol - published October 2, 2017
2. Bahrami AH, Lin MG, Ren X, Hurley JH, Hummer G
The Battle of RNA Synthesis: Virus versus Host.
1. Viruses - published October 2, 2017
2. Harwig A, Landick R, Berkhout B
GRcalculator: an online tool for calculating and mining dose-response data.
1. BMC Cancer - published October 2, 2017
2. Clark NA, Hafner M, Kouril M, Williams EH, Muhlich JL, Pilarczyk M, Niepel M, Sorger PK, Medvedovic M
Assessment of Contact Predictions in CASP12: Co-Evolution and Deep Learning Coming of Age.
1. Proteins - published October 2, 2017
2. Schaarschmidt J, Monastyrskyy B, Kryshtafovych A, Bonvin AMJJ
The Structure of Glucose-1-Phosphate Thymidylyltransferase from Mycobacterium tuberculosis Reveals the Location of an Essential Magnesium Ion in the RmlA-type Enzymes.
1. Protein Sci - published October 2, 2017
2. Brown HA, Thoden JB, Tipton PA, Holden HM
In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA).
1. PLoS Pathog - published October 2, 2017
2. Sychantha D, Jones CS, Little DJ, Moynihan PJ, Robinson H, Galley NF, Roper DI, Dowson CG, Howell PL, Clarke AJ
Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion.
1. Science - published October 2, 2017
2. Nasamu AS, Glushakova S, Russo I, Vaupel B, Oksman A, Kim AS, Fremont DH, Tolia N, Beck JR, Meyers MJ, Niles JC, Zimmerberg J, Goldberg DE
Functional analyses of the CIF1-CIF2 complex in trypanosome identify the structural motifs required for cytokinesis.
1. J Cell Sci - published October 2, 2017
2. Hu H, Majneri P, Li D, Kurasawa Y, An T, Dong G, Li Z
Resveratrol: a novel type of topoisomerase II inhibitor.
1. J Biol Chem - published October 2, 2017
2. Lee JH, Wendorff TJ, Berger JM
Efficient preparation of Arabidopsis pollen tubes for ultrastructural analysis using chemical and cryo-fixation.
1. BMC Plant Biol - published October 2, 2017
2. Ndinyanka Fabrice T, Kaech A, Barmettler G, Eichenberger C, Knox JP, Grossniklaus U, Ringli C
Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.
1. Bioorg Med Chem - published October 2, 2017
2. LaRochelle JR, Fodor M, Ellegast JM, Liu X, Vemulapalli V, Mohseni M, Stams T, Buhrlage SJ, Stegmaier K, LaMarche MJ, Acker MG, Blacklow SC
Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.
1. Mol Cell - published October 2, 2017
2. Su MY, Morris KL, Kim DJ, Fu Y, Lawrence R, Stjepanovic G, Zoncu R, Hurley JH
Clickable Substrate Mimics Enable Imaging of Phospholipase D Activity.
1. ACS Cent Sci - published October 2, 2017
2. Bumpus TW, Baskin JM
Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation.
1. Cell Host Microbe - published October 2, 2017
2. Meyerson NR, Zhou L, Guo YR, Zhao C, Tao YJ, Krug RM, Sawyer SL
Kinetic origin of substrate specificity in post-transfer editing by leucyl-tRNA synthetase.
1. J Mol Biol - published October 2, 2017
2. Dulic M, Cvetesic N, Zivkovic I, Palencia A, Cusack S, Bertosa B, Gruic-Sovulj I
Induced pluripotent stem cells derived from an autosomal dominant polycystic kidney disease patient carrying a PKD1 Q533X mutation.
1. Stem Cell Res - published October 2, 2017
2. Lee JJ, Ho MC, Huang CY, Wen CH, Cheng YC, Hsu YH, Hwang DY, Lu HE, Chen HC, Hsieh PCH
Lymph node ratio, but not the total number of examined lymph nodes or lymph node metastasis, is a predictor of overall survival for pancreatic neuroendocrine neoplasms after surgical resection.
1. Oncotarget - published October 2, 2017
2. Liu P, Zhang X, Shang Y, Lu L, Cao F, Sun M, Tang Z, Vollmar B, Gong P
In Silico prediction of the molecular basis of ClTx and AaCTx interaction with matrix metalloproteinase-2 (MMP-2) to inhibit glioma cell invasion.
1. J Biomol Struct Dyn - published October 1, 2017
2. Othman H, Wieninger SA, ElAyeb M, Nilges M, Srairi-Abid N
Beyond Fourier.
1. J Magn Reson - published October 1, 2017
2. Hoch JC
Repurposing bacterial toxins for intracellular delivery of therapeutic proteins.
1. Biochem Pharmacol - published October 1, 2017
2. Beilhartz GL, Sugiman-Marangos SN, Melnyk RA
Protein conformational dynamics studied by ¹⁵N and ¹H R_1ρ relaxation dispersion: Application to wild-type and G53A ubiquitin crystals.
1. Solid State Nucl Magn Reson - published October 1, 2017
2. Gauto DF, Hessel A, Rovó P, Kurauskas V, Linser R, Schanda P
Challenges and opportunities in the high-resolution cryo-EM visualization of microtubules and their binding partners.
1. Curr Opin Struct Biol - published October 1, 2017
2. Nogales E, Kellogg EH
Interferon-Stimulated Genes Are Transcriptionally Repressed by PR in Breast Cancer.
1. Mol Cancer Res - published October 1, 2017
2. Walter KR, Goodman ML, Singhal H, Hall JA, Li T, Holloran SM, Trinca GM, Gibson KA, Jin VX, Greene GL, Hagan CR
Mycobacterium abscessus l,d-Transpeptidases Are Susceptible to Inactivation by Carbapenems and Cephalosporins but Not Penicillins.
1. Antimicrob Agents Chemother - published October 1, 2017
2. Kumar P, Chauhan V, Silva JRA, Lameira J, d'Andrea FB, Li SG, Ginell SL, Freundlich JS, Alves CN, Bailey S, Cohen KA, Lamichhane G
How Hsp90 and Cdc37 Lubricate Kinase Molecular Switches.
1. Trends Biochem Sci - published October 1, 2017
2. Verba KA, Agard DA
Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling.
1. J Cell Sci - published October 1, 2017
2. Cohen N, Breker M, Bakunts A, Pesek K, Chas A, Argemí J, Orsi A, Gal L, Chuartzman S, Wigelman Y, Jonas F, Walter P, Ernst R, Aragón T, van Anken E, Schuldiner M
AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma.
1. Nat Neurosci - published October 1, 2017
2. Chow RD, Guzman CD, Wang G, Schmidt F, Youngblood MW, Ye L, Errami Y, Dong MB, Martinez MA, Zhang S, Renauer P, Bilguvar K, Gunel M, Sharp PA, Zhang F, Platt RJ, Chen S
ER remodeling by the large GTPase atlastin promotes vacuolar growth of Legionella pneumophila.
1. EMBO Rep - published October 1, 2017
2. Steiner B, Swart AL, Welin A, Weber S, Personnic N, Kaech A, Freyre C, Ziegler U, Klemm RW, Hilbi H
Urease Inhibition in the Presence of N-(n-Butyl)thiophosphoric Triamide, a Suicide Substrate: Structure and Kinetics.
1. Biochemistry - published October 1, 2017
2. Mazzei L, Cianci M, Contaldo U, Musiani F, Ciurli S
Amyloid β Fibril Elongation by Monomers Involves Disorder at the Tip.
1. J Chem Theory Comput - published October 1, 2017
2. Bacci M, Vymětal J, Mihajlovic M, Caflisch A, Vitalis A
cGAS Conducts Micronuclei DNA Surveillance.
1. Trends Cell Biol - published October 1, 2017
2. de Oliveira Mann CC, Kranzusch PJ
Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.
1. Nat Struct Mol Biol - published October 1, 2017
2. Knott GJ, East-Seletsky A, Cofsky JC, Holton JM, Charles E, O'Connell MR, Doudna JA
Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase.
1. Biochemistry - published October 1, 2017
2. Ashley RE, Blower TR, Berger JM, Osheroff N
Polymer Conjugation to Enhance Cellulase Activity and Preserve Thermal and Functional Stability.
1. Bioconjug Chem - published October 1, 2017
2. Wright TA, Lucius Dougherty M, Schmitz B, Burridge KM, Makaroff K, Stewart JM, Fischesser HD, Shepherd JT, Berberich JA, Konkolewicz D, Page RC
4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.
1. J Am Chem Soc - published October 1, 2017
2. Malek-Adamian E, Guenther DC, Matsuda S, Martínez-Montero S, Zlatev I, Harp J, Burai Patrascu M, Foster DJ, Fakhoury J, Perkins L, Moitessier N, Manoharan RM, Taneja N, Bisbe A, Charisse K, Maier M, Rajeev KG, Egli M, Manoharan M, Damha MJ
Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies.
1. Proc Natl Acad Sci U S A - published October 1, 2017
2. Sathiyamoorthy K, Jiang J, Möhl BS, Chen J, Zhou ZH, Longnecker R, Jardetzky TS
Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.
1. Nat Cell Biol - published October 1, 2017
2. Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, Moldoveanu T, Lum L
Dietary Manganese Promotes Staphylococcal Infection of the Heart.
1. Cell Host Microbe - published October 1, 2017
2. Juttukonda LJ, Berends ETM, Zackular JP, Moore JL, Stier MT, Zhang Y, Schmitz JE, Beavers WN, Wijers CD, Gilston BA, Kehl-Fie TE, Atkinson J, Washington MK, Peebles RS, Chazin WJ, Torres VJ, Caprioli RM, Skaar EP
Borylated oximes: versatile building blocks for organic synthesis.
1. Chem Commun (Camb) - published October 1, 2017
2. Liew SK, Holownia A, Diaz DB, Cistrone PA, Dawson PE, Yudin AK
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures.
1. Proc Natl Acad Sci U S A - published October 1, 2017
2. Dang B, Wu H, Mulligan VK, Mravic M, Wu Y, Lemmin T, Ford A, Silva DA, Baker D, DeGrado WF
Chemical substitutions in the selectivity filter of potassium channels do not rule out constricted-like conformations for C-type inactivation.
1. Proc Natl Acad Sci U S A - published October 1, 2017
2. Li J, Ostmeyer J, Boulanger E, Rui H, Perozo E, Roux B
RNA targeting with CRISPR-Cas13.
1. Nature - published October 1, 2017
2. Abudayyeh OO, Gootenberg JS, Essletzbichler P, Han S, Joung J, Belanto JJ, Verdine V, Cox DBT, Kellner MJ, Regev A, Lander ES, Voytas DF, Ting AY, Zhang F
Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins.
1. Proc Natl Acad Sci U S A - published October 1, 2017
2. Larsen ISB, Narimatsu Y, Joshi HJ, Siukstaite L, Harrison OJ, Brasch J, Goodman KM, Hansen L, Shapiro L, Honig B, Vakhrushev SY, Clausen H, Halim A
Catheterization alters bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract.
1. Proc Natl Acad Sci U S A - published October 1, 2017
2. Walker JN, Flores-Mireles AL, Pinkner CL, Schreiber HL 4th, Joens MS, Park AM, Potretzke AM, Bauman TM, Pinkner JS, Fitzpatrick JAJ, Desai A, Caparon MG, Hultgren SJ
Dodecyl-β-melibioside Detergent Micelles as a Medium for Membrane Proteins.
1. Biochemistry - published October 1, 2017
2. Hutchison JM, Lu Z, Li GC, Travis B, Mittal R, Deatherage CL, Sanders CR
6S RNA Mimics B-Form DNA to Regulate Escherichia coli RNA Polymerase.
1. Mol Cell - published October 1, 2017
2. Chen J, Wassarman KM, Feng S, Leon K, Feklistov A, Winkelman JT, Li Z, Walz T, Campbell EA, Darst SA
EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.
1. Cell - published October 1, 2017
2. Freed DM, Bessman NJ, Kiyatkin A, Salazar-Cavazos E, Byrne PO, Moore JO, Valley CC, Ferguson KM, Leahy DJ, Lidke DS, Lemmon MA
X-ray and EM structures of a natively glycosylated HIV-1 envelope trimer.
1. Acta Crystallogr D Struct Biol - published October 1, 2017
2. Gristick HB, Wang H, Bjorkman PJ
Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.
1. Nature - published October 1, 2017
2. Chen Q, She J, Zeng W, Guo J, Xu H, Bai XC, Jiang Y
Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding.
1. Elife - published October 1, 2017
2. Adell MAY, Migliano SM, Upadhyayula S, Bykov YS, Sprenger S, Pakdel M, Vogel GF, Jih G, Skillern W, Behrouzi R, Babst M, Schmidt O, Hess MW, Briggs JA, Kirchhausen T, Teis D
Human TRPML1 channel structures in open and closed conformations.
1. Nature - published October 1, 2017
2. Schmiege P, Fine M, Blobel G, Li X
Predicting the Functional Impact of KCNQ1 Variants of Unknown Significance.
1. Circ Cardiovasc Genet - published October 1, 2017
2. Li B, Mendenhall JL, Kroncke BM, Taylor KC, Huang H, Smith DK, Vanoye CG, Blume JD, George AL Jr, Sanders CR, Meiler J
Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2.
1. Cell Death Dis - published October 1, 2017
2. Merski M, Moreira C, Abreu RM, Ramos MJ, Fernandes PA, Martins LM, Pereira PJB, Macedo-Ribeiro S
Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration.
1. Neuron - published October 1, 2017
2. Pease-Raissi SE, Pazyra-Murphy MF, Li Y, Wachter F, Fukuda Y, Fenstermacher SJ, Barclay LA, Bird GH, Walensky LD, Segal RA
Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water.
1. Science - published October 1, 2017
2. Riback JA, Bowman MA, Zmyslowski AM, Knoverek CR, Jumper JM, Hinshaw JR, Kaye EB, Freed KF, Clark PL, Sosnick TR
Structure of RNA polymerase bound to ribosomal 30S subunit.
1. Elife - published October 1, 2017
2. Demo G, Rasouly A, Vasilyev N, Svetlov V, Loveland AB, Diaz-Avalos R, Grigorieff N, Nudler E, Korostelev AA
NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression.
1. Nat Commun - published October 1, 2017
2. Ju J, Chen A, Deng Y, Liu M, Wang Y, Wang Y, Nie M, Wang C, Ding H, Yao B, Gui T, Li X, Xu Z, Ma C, Song Y, Kvansakul M, Zen K, Zhang CY, Luo C, Fang M, Huang DCS, Allis CD, Tan R, Zeng CK, Wei J, Zhao Q
A retractable lid in lecithin:cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I.
1. J Biol Chem - published October 1, 2017
2. Manthei KA, Ahn J, Glukhova A, Yuan W, Larkin C, Manett TD, Chang L, Shayman JA, Axley MJ, Schwendeman A, Tesmer JJG
Structure-based nuclear import mechanism of histones H3 and H4 mediated by Kap123.
1. Elife - published October 1, 2017
2. An S, Yoon J, Kim H, Song JJ, Cho US
Generation of induced pluripotent stem cells derived from an autosomal dominant polycystic kidney disease patient with a p.Ser1457fs mutation in PKD1.
1. Stem Cell Res - published October 1, 2017
2. Huang CY, Ho MC, Lee JJ, Hwang DY, Ko HW, Cheng YC, Hsu YH, Lu HE, Chen HC, Hsieh PCH
Structural biology of GABAB receptor.
1. Neuropharmacology - published October 1, 2017
2. Frangaj A, Fan QR
A quantitative comparison of cytosolic delivery via different protein uptake systems.
1. Sci Rep - published October 1, 2017
2. Verdurmen WPR, Mazlami M, Plückthun A
Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles.
1. Cell Rep - published October 1, 2017
2. Melia CE, van der Schaar HM, Lyoo H, Limpens RWAL, Feng Q, Wahedi M, Overheul GJ, van Rij RP, Snijder EJ, Koster AJ, Bárcena M, van Kuppeveld FJM
Unraveling the Self-Assembly of the Pseudomonas aeruginosa XcpQ Secretin Periplasmic Domain Provides New Molecular Insights into Type II Secretion System Secreton Architecture and Dynamics.
1. mBio - published October 1, 2017
2. Douzi B, Trinh NTT, Michel-Souzy S, Desmyter A, Ball G, Barbier P, Kosta A, Durand E, Forest KT, Cambillau C, Roussel A, Voulhoux R
Homodimeric Kinesin-2 KIF3CC Promotes Microtubule Dynamics.
1. Biophys J - published October 1, 2017
2. Guzik-Lendrum S, Rayment I, Gilbert SP
A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas.
1. Cell Rep - published October 1, 2017
2. Ryan RJH, Petrovic J, Rausch DM, Zhou Y, Lareau CA, Kluk MJ, Christie AL, Lee WY, Tarjan DR, Guo B, Donohue LKH, Gillespie SM, Nardi V, Hochberg EP, Blacklow SC, Weinstock DM, Faryabi RB, Bernstein BE, Aster JC, Pear WS
APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA.
1. Nat Commun - published October 1, 2017
2. Bohn JA, Thummar K, York A, Raymond A, Brown WC, Bieniasz PD, Hatziioannou T, Smith JL
The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.
1. Nat Commun - published October 1, 2017
2. Herschhorn A, Gu C, Moraca F, Ma X, Farrell M, Smith AB 3rd, Pancera M, Kwong PD, Schön A, Freire E, Abrams C, Blanchard SC, Mothes W, Sodroski JG
Using two-site binding models to analyze microscale thermophoresis data.
1. Anal Biochem - published October 1, 2017
2. Tso SC, Chen Q, Vishnivetskiy SA, Gurevich VV, Iverson TM, Brautigam CA
Generation of an induced pluripotent stem cell line, IBMS-iPSC-014-05, from a female autosomal dominant polycystic kidney disease patient carrying a common mutation of R803X in PKD2.
1. Stem Cell Res - published October 1, 2017
2. Ho MC, Huang CY, Lee JJ, Hsu SH, Cheng YC, Hsu YH, Hwang DY, Lu HE, Chen HC, Hsieh PCH
Manipulation of cytokine secretion in human dendritic cells using glycopolymers with picomolar affinity for DC-SIGN.
1. Chem Sci - published October 1, 2017
2. Mitchell DA, Zhang Q, Voorhaar L, Haddleton DM, Herath S, Gleinich AS, Randeva HS, Crispin M, Lehnert H, Wallis R, Patterson S, Becer CR